xamoterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 2848 81801-12-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xamoterol
  • xamoterol fumarate
  • xamoterol hemifumarate
A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.
  • Molecular weight: 339.39
  • Formula: C16H25N3O5
  • CLOGP: 0.24
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 103.29
  • ALOGS: -1.99
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 7 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.64 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.97 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CX07 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Other cardiac stimulants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058665 Adrenergic beta-1 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.48 acidic
pKa2 13.78 acidic
pKa3 7.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Kd 7.75 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.18 CHEMBL
Beta-3 adrenergic receptor GPCR Kd 4.70 CHEMBL

External reference:

IDSource
N0000167043 NUI
D06328 KEGG_DRUG
73210-73-8 SECONDARY_CAS_RN
C0078595 UMLSCUI
CHEBI:10055 CHEBI
CHEMBL75753 ChEMBL_ID
DB13781 DRUGBANK_ID
D017307 MESH_DESCRIPTOR_UI
155774 PUBCHEM_CID
538 IUPHAR_LIGAND_ID
5271 INN_ID
7HE0JQL703 UNII
39801 RXNORM
004066 NDDF
004067 NDDF
349941002 SNOMEDCT_US
418668004 SNOMEDCT_US
CHEMBL1329567 ChEMBL_ID
CHEMBL2104466 ChEMBL_ID
CHEMBL1256945 ChEMBL_ID

Pharmaceutical products:

None