xamoterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| bronchodilators, phenethylamine derivatives | 2848 | 81801-12-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.40 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 7 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.64 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.97 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7.70 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 19.87 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01CX07 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Other cardiac stimulants |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058665 | Adrenergic beta-1 Receptor Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.48 | acidic |
| pKa2 | 13.78 | acidic |
| pKa3 | 7.77 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | Kd | 7.75 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 6.18 | CHEMBL | |||||
| Beta-3 adrenergic receptor | GPCR | Kd | 4.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167043 | NUI |
| D06328 | KEGG_DRUG |
| C0078595 | UMLSCUI |
| CHEBI:10055 | CHEBI |
| CHEMBL75753 | ChEMBL_ID |
| DB13781 | DRUGBANK_ID |
| D017307 | MESH_DESCRIPTOR_UI |
| 155774 | PUBCHEM_CID |
| 538 | IUPHAR_LIGAND_ID |
| 5271 | INN_ID |
| 73210-73-8 | SECONDARY_CAS_RN |
| 7HE0JQL703 | UNII |
| 39801 | RXNORM |
| 004066 | NDDF |
| 004067 | NDDF |
| 349941002 | SNOMEDCT_US |
| 418668004 | SNOMEDCT_US |
| CHEMBL1329567 | ChEMBL_ID |
| CHEMBL2104466 | ChEMBL_ID |
| CHEMBL1256945 | ChEMBL_ID |
Pharmaceutical products:
None