aceclidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
muscarinic receptors agonists/antagonists 4314 827-61-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aceclidine hydrochloride
  • aceclidine
  • aceclidin
  • 3-Quinuclidinol acetate
  • 3-Quinuclidinyl acetate
  • aceclidine HCl
cholinomimetic used to reduce intraocular pressure in glaucoma
  • Molecular weight: 169.22
  • Formula: C9H15NO2
  • CLOGP: 0.74
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: 0.13
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EB08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
ATC S01EB58 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
MeSH PA D008916 Miotics
MeSH PA D010277 Parasympathomimetics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Open-angle glaucoma indication 84494001 DOID:1067

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR AGONIST EC50 5 IUPHAR
Muscarinic acetylcholine receptor M2 GPCR AGONIST EC50 5.70 IUPHAR
Muscarinic acetylcholine receptor M3 GPCR AGONIST EC50 5.10 IUPHAR
Muscarinic acetylcholine receptor M5 GPCR AGONIST EC50 5.10 IUPHAR
Muscarinic acetylcholine receptor M4 GPCR AGONIST EC50 4.80 IUPHAR
Muscarinic acetylcholine receptor GPCR Ki 5.08 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR IC50 6.92 CHEMBL

External reference:

IDSource
D02750 KEGG_DRUG
0578K3ELIO UNII
1367 INN_ID
6109-70-2 SECONDARY_CAS_RN
005218 NDDF
CHEMBL20835 ChEMBL_ID
CHEBI:93847 CHEBI
DB13262 DRUGBANK_ID
1979 PUBCHEM_CID
C084650 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None