aceclidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
muscarinic receptors agonists/antagonists	4314	827-61-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aceclidine hydrochloride
aceclidine
aceclidin
3-Quinuclidinol acetate
3-Quinuclidinyl acetate
aceclidine HCl

cholinomimetic used to reduce intraocular pressure in glaucoma

Molecular weight: 169.22
Formula: C9H15NO2
CLOGP: 0.74
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 29.54
ALOGS: 0.13
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01EB08	SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics
ATC	S01EB58	SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics
MeSH PA	D008916	Miotics
MeSH PA	D010277	Parasympathomimetics
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Open-angle glaucoma	indication	84494001	DOID:1067

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.34	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	AGONIST	EC50	5		IUPHAR
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	AGONIST	EC50	5.70		IUPHAR
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	AGONIST	EC50	5.10		IUPHAR
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	AGONIST	EC50	4.80		IUPHAR
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN	AGONIST	EC50	5.10		IUPHAR
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		IC50	6.92		CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		Ki	5.08		CHEMBL

External reference:

ID	Source
D02750	KEGG_DRUG
6109-70-2	SECONDARY_CAS_RN
C0000948	UMLSCUI
CHEBI:93847	CHEBI
CHEMBL20835	ChEMBL_ID
DB13262	DRUGBANK_ID
C084650	MESH_SUPPLEMENTAL_RECORD_UI
1367	INN_ID
0578K3ELIO	UNII
1979	PUBCHEM_CID
005218	NDDF
005219	NDDF

Pharmaceutical products:

None