sennosides 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4307 104428-88-8

Description:

MoleculeDescription

Synonyms:

  • sennosides a&b
  • sennosides a and b
  • sennosides
Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.
  • Molecular weight: 1725.49
  • Formula: C84H76O40
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Constipation 398.50 9.89 968 93255 223975 63170824
Drug ineffective 380.95 9.89 605 93618 1044160 62350639
Pemphigus 244.14 9.89 6 94217 183720 63211079
Systemic lupus erythematosus 241.27 9.89 18 94205 208900 63185899
Temperature regulation disorder 235.58 9.89 134 94089 5998 63388801
Hand deformity 212.65 9.89 5 94218 159452 63235347
Pneumonia aspiration 208.81 9.89 257 93966 34283 63360516
Synovitis 192.58 9.89 25 94198 186893 63207906
Maternal exposure during pregnancy 183.16 9.89 50 94173 220012 63174787
Glossodynia 181.71 9.89 25 94198 178851 63215948
Arthropathy 173.06 9.89 66 94157 234726 63160073
Food allergy 172.84 9.89 140 94083 11261 63383538
Therapeutic product effect decreased 164.35 9.89 42 94181 193145 63201654
Drug intolerance 150.30 9.89 142 94081 308519 63086280
Coeliac disease 148.83 9.89 135 94088 12662 63382137
Alopecia 142.45 9.89 175 94048 337361 63057438
Discomfort 137.42 9.89 39 94184 167335 63227464
Plasma cell myeloma 131.42 9.89 210 94013 35695 63359104
Joint swelling 130.91 9.89 177 94046 327489 63067310
Gastrooesophageal reflux disease 130.58 9.89 374 93849 95265 63299534
Immunodeficiency 126.11 9.89 153 94070 20101 63374698
Wound 123.44 9.89 44 94179 163219 63231580
Pulmonary embolism 122.95 9.89 417 93806 116267 63278532
Treatment failure 122.02 9.89 72 94151 198971 63195828
Fluid retention 118.56 9.89 269 93954 59417 63335382
Helicobacter infection 112.99 9.89 6 94217 92779 63302020
Completed suicide 112.29 9.89 38 94185 145635 63249164
Duodenal ulcer perforation 111.60 9.89 4 94219 87205 63307594
Dehydration 110.00 9.89 529 93694 172825 63221974
Pericarditis 107.37 9.89 31 94192 131548 63263251
Swelling 101.82 9.89 157 94066 275221 63119578
Mental status changes 98.95 9.89 196 94027 39403 63355396
Deep vein thrombosis 96.77 9.89 309 93914 83491 63311308
Back pain 94.90 9.89 694 93529 263451 63131348
Pleural effusion 94.57 9.89 329 93894 92881 63301918
Off label use 93.21 9.89 603 93620 673859 62720940
Upper respiratory tract infection 90.64 9.89 298 93925 81749 63313050
Abdominal discomfort 90.61 9.89 215 94008 320670 63074129
Psoriatic arthropathy 90.09 9.89 14 94209 91506 63303293
Contraindicated product administered 87.42 9.89 117 94106 217531 63177268
Folliculitis 87.36 9.89 4 94219 70313 63324486
Muscle injury 83.60 9.89 3 94220 65342 63329457
Hyperhidrosis 82.55 9.89 348 93875 107488 63287311
Arthralgia 82.42 9.89 502 93721 569208 62825591
Rash erythematous 81.55 9.89 189 94034 42321 63352478
Salpingo-oophorectomy unilateral 81.37 9.89 35 94188 846 63393953
Condition aggravated 79.72 9.89 317 93906 401900 62992899
Oedema peripheral 77.47 9.89 514 93709 188997 63205802
Sinusitis fungal 75.72 9.89 42 94181 1789 63393010
Drug interaction 75.13 9.89 141 94082 228990 63165809
Haemoglobin decreased 73.60 9.89 417 93806 145068 63249731
Coma 72.18 9.89 235 93988 64129 63330670
Pneumonia 71.19 9.89 1010 93213 455757 62939042
Bursitis 70.29 9.89 164 94059 36877 63357922
Sputum increased 69.20 9.89 44 94179 2415 63392384
Platelet count decreased 65.57 9.89 343 93880 115779 63279020
Product use issue 65.23 9.89 144 94079 220376 63174423
Liver injury 64.99 9.89 7 94216 60513 63334286
Embolism venous 63.81 9.89 46 94177 3108 63391691
Toxicity to various agents 61.82 9.89 176 94047 247074 63147725
Infection 59.63 9.89 160 94063 229013 63165786
Diastolic dysfunction 59.55 9.89 60 94163 6411 63388388
Irritable bowel syndrome 59.27 9.89 24 94199 82388 63312411
Exposure during pregnancy 59.06 9.89 87 94136 155460 63239339
Febrile neutropenia 58.90 9.89 338 93885 118111 63276688
Therapeutic product effect incomplete 57.92 9.89 60 94163 124996 63269803
Oesophageal spasm 57.43 9.89 43 94180 3080 63391719
Musculoskeletal stiffness 56.72 9.89 118 94105 184500 63210299
Failure to thrive 55.98 9.89 61 94162 7137 63387662
Oesophageal pain 55.15 9.89 45 94178 3656 63391143
Respiratory symptom 54.78 9.89 43 94180 3304 63391495
Asthma 53.92 9.89 349 93874 127212 63267587
Diverticulum 52.15 9.89 76 94147 11915 63382884
Asthenia 51.08 9.89 826 93397 382778 63012021
Anaemia 51.01 9.89 662 93561 292768 63102031
Small intestinal obstruction 51.00 9.89 95 94128 18242 63376557
Sleep apnoea syndrome 50.98 9.89 125 94098 29008 63365791
Hiatus hernia 50.50 9.89 104 94119 21490 63373309
Intentional overdose 49.54 9.89 24 94199 74128 63320671
Urinary tract infection 49.35 9.89 605 93618 264079 63130720
Abdominal pain 46.45 9.89 651 93572 292805 63101994
Total lung capacity decreased 44.53 9.89 32 94191 2151 63392648
Iron deficiency anaemia 44.16 9.89 94 94129 19875 63374924
Cardiac failure congestive 44.15 9.89 261 93962 92172 63302627
Product use in unapproved indication 43.63 9.89 129 94094 178951 63215848
Ileus 43.11 9.89 78 94145 14647 63380152
Somnolence 42.69 9.89 429 93794 178256 63216543
Blister 42.41 9.89 80 94143 129734 63265065
Chronic sinusitis 41.45 9.89 71 94152 12772 63382027
Gastrointestinal disorder 41.04 9.89 83 94140 131156 63263643
Eosinophil percentage increased 40.91 9.89 23 94200 1006 63393793
Intentional product use issue 40.75 9.89 80 94143 127812 63266987
Blood uric acid decreased 40.50 9.89 21 94202 780 63394019
Knee arthroplasty 40.28 9.89 15 94208 54191 63340608
White blood cell count decreased 40.27 9.89 348 93875 138756 63256043
Neutrophil count decreased 40.04 9.89 178 94045 56228 63338571
Fungal infection 39.87 9.89 133 94090 36741 63358058
Nasal polyps 39.85 9.89 47 94176 5992 63388807
Blood cholesterol increased 39.31 9.89 49 94174 93983 63300816
Impaired healing 39.25 9.89 57 94166 102485 63292314
Cestode infection 38.85 9.89 15 94208 272 63394527
Tricuspid valve incompetence 38.50 9.89 74 94149 14547 63380252
Lung opacity 37.97 9.89 34 94189 3134 63391665
Aspiration 37.70 9.89 62 94161 10789 63384010
Inflammation 37.50 9.89 40 94183 82233 63312566
Female genital tract fistula 37.46 9.89 51 94172 7508 63387291
Peritonitis bacterial 37.33 9.89 41 94182 4838 63389961
Bronchopulmonary aspergillosis allergic 36.94 9.89 29 94194 2229 63392570
Rheumatoid arthritis 36.38 9.89 224 93999 253595 63141204
Hypoxia 35.39 9.89 179 94044 59613 63335186
Carbohydrate antigen 125 increased 35.30 9.89 31 94192 2785 63392014
Malignant neoplasm progression 34.27 9.89 224 93999 81897 63312902
General physical health deterioration 32.49 9.89 171 94052 201231 63193568
Abortion spontaneous 31.94 9.89 15 94208 47180 63347619
Blood calcium increased 31.91 9.89 53 94170 9297 63385502
Blood creatinine decreased 31.48 9.89 40 94183 5505 63389294
Type 2 diabetes mellitus 31.46 9.89 29 94194 63839 63330960
Magnesium deficiency 31.31 9.89 16 94207 576 63394223
Red blood cell sedimentation rate increased 31.31 9.89 13 94210 43969 63350830
Foetal exposure during pregnancy 31.19 9.89 5 94218 31957 63362842
Lymphoedema 30.57 9.89 59 94164 11633 63383166
Respiratory failure 29.04 9.89 254 93969 101604 63293195
Decreased appetite 28.79 9.89 528 93695 250524 63144275
Haemorrhoids 28.64 9.89 85 94138 22065 63372734
Disease progression 28.47 9.89 293 93930 122465 63272334
Premenstrual syndrome 28.39 9.89 16 94207 703 63394096
Emphysema 28.36 9.89 55 94168 10883 63383916
Obstructive airways disorder 28.27 9.89 81 94142 20618 63374181
Mobility decreased 27.57 9.89 90 94133 121069 63273730
Accidental exposure to product 27.40 9.89 4 94219 27401 63367398
Hepatocellular injury 27.37 9.89 4 94219 27377 63367422
Therapy non-responder 27.31 9.89 44 94179 75857 63318942
Device expulsion 27.08 9.89 9 94214 34913 63359886
Vomiting 27.00 9.89 1050 93173 558567 62836232
Fall 26.25 9.89 765 93458 391569 63003230
Suicide attempt 26.25 9.89 31 94192 60887 63333912
Granulocytopenia 26.20 9.89 37 94186 5635 63389164
Dental restoration failure 26.14 9.89 17 94206 970 63393829
Hallucination 25.66 9.89 154 94069 54663 63340136
Peripheral swelling 25.42 9.89 262 93961 265680 63129119
International normalised ratio increased 25.41 9.89 136 94087 46289 63348510
Adverse drug reaction 25.27 9.89 50 94173 79664 63315135
Live birth 25.03 9.89 4 94219 25626 63369173
Blood sodium decreased 24.92 9.89 86 94137 24166 63370633
Abdominal distension 24.69 9.89 216 94007 86399 63308400
Death 24.50 9.89 728 93495 373653 63021146
Loss of personal independence in daily activities 24.47 9.89 69 94154 97221 63297578
Ill-defined disorder 24.46 9.89 53 94170 81702 63313097
Lichen sclerosus 24.34 9.89 17 94206 1092 63393707
Lip pruritus 24.32 9.89 16 94207 931 63393868
Drug abuse 24.29 9.89 44 94179 72474 63322325
Hip arthroplasty 24.23 9.89 21 94202 47625 63347174
Cellulitis 24.21 9.89 206 94017 81752 63313047
Drug reaction with eosinophilia and systemic symptoms 24.09 9.89 10 94213 33826 63360973
Chronic obstructive pulmonary disease 23.77 9.89 167 94056 62519 63332280
Dysphagia 23.76 9.89 218 94005 88367 63306432
Drug resistance 23.75 9.89 3 94220 22930 63371869
Hysterectomy 23.70 9.89 47 94176 9452 63385347
Spinal compression fracture 23.63 9.89 60 94163 14223 63380576
Tinnitus 23.47 9.89 110 94113 35518 63359281
Hypophagia 23.21 9.89 100 94123 31159 63363640
C-reactive protein increased 23.21 9.89 68 94155 94639 63300160
Injection site erythema 23.20 9.89 56 94167 83118 63311681
Injection site reaction 22.92 9.89 32 94191 58492 63336307
Polymenorrhoea 22.87 9.89 17 94206 1204 63393595
Therapeutic response decreased 22.76 9.89 35 94188 61490 63333309
Hepatotoxicity 21.83 9.89 14 94209 37027 63357772
Nausea 21.69 9.89 1508 92715 852963 62541836
Pregnancy 21.61 9.89 14 94209 36822 63357977
Injection site pain 21.60 9.89 109 94114 129691 63265108
Drug hypersensitivity 21.47 9.89 328 93895 310359 63084440
Sinusitis 21.37 9.89 224 93999 226429 63168370
Rash 21.06 9.89 653 93570 560218 62834581
Intentional self-injury 21.03 9.89 6 94217 25681 63369118
Atelectasis 20.20 9.89 74 94149 21409 63373390
Hip fracture 20.16 9.89 92 94131 29382 63365417
Rales 19.63 9.89 52 94171 12645 63382154
Hospice care 19.49 9.89 39 94184 7893 63386906
Haematocrit decreased 19.36 9.89 112 94111 39228 63355571
Gastrointestinal haemorrhage 18.93 9.89 194 94029 80982 63313817
Ecchymosis 18.77 9.89 47 94176 11047 63383752
Grip strength decreased 18.63 9.89 5 94218 22282 63372517
Anxiety 18.53 9.89 438 93785 217103 63177696
Adverse event 18.44 9.89 46 94177 67513 63327286
Blood potassium decreased 18.36 9.89 116 94107 41910 63352889
Injection site pruritus 18.34 9.89 24 94199 45092 63349707
Dyspnoea 18.33 9.89 1176 93047 660137 62734662
Candida infection 18.29 9.89 87 94136 28264 63366535
Cystitis 18.28 9.89 142 94081 54849 63339950
Decubitus ulcer 18.25 9.89 45 94178 10475 63384324
Infusion related reaction 18.07 9.89 256 93967 245265 63149534
Menstruation delayed 17.71 9.89 17 94206 1712 63393087
Injection site swelling 17.66 9.89 27 94196 47545 63347254
Malignant neoplasm of thorax 17.36 9.89 4 94219 9 63394790
Lower gastrointestinal haemorrhage 17.28 9.89 37 94186 7853 63386946
Hyperaesthesia 17.28 9.89 41 94182 9317 63385482
Intestinal obstruction 17.23 9.89 91 94132 30808 63363991
Sepsis 17.17 9.89 321 93902 152802 63241997
Hypersensitivity 16.96 9.89 319 93904 292366 63102433
Blood creatinine increased 16.85 9.89 202 94021 87642 63307157
Bone erosion 16.78 9.89 3 94220 17714 63377085
Cholinergic syndrome 16.43 9.89 10 94213 508 63394291
Blood urea increased 16.33 9.89 80 94143 26299 63368500
Acute respiratory failure 16.21 9.89 97 94126 34388 63360411
Compression fracture 16.20 9.89 32 94191 6416 63388383
Cardiac murmur 16.18 9.89 53 94170 14499 63380300
Cholestasis 16.18 9.89 12 94211 29422 63365377
Drug ineffective for unapproved indication 16.15 9.89 16 94207 34047 63360752
Non-small cell lung cancer 15.94 9.89 23 94200 3572 63391227
Heart rate increased 15.66 9.89 211 94012 94027 63300772
Erythema 15.62 9.89 356 93867 175395 63219404
Body temperature fluctuation 15.44 9.89 18 94205 2267 63392532
Blood alkaline phosphatase increased 15.43 9.89 113 94110 42854 63351945
Hypervolaemia 15.38 9.89 83 94140 28330 63366469
Pyrexia 15.14 9.89 848 93375 469630 62925169
Ascites 15.14 9.89 108 94115 40620 63354179
Breath sounds abnormal 15.04 9.89 43 94180 10930 63383869
Pneumonia viral 14.94 9.89 35 94188 7887 63386912
Blood test abnormal 14.83 9.89 54 94169 15575 63379224
Arthritis 14.73 9.89 106 94117 115815 63278984
Cholecystitis chronic 14.59 9.89 41 94182 10320 63384479
Unresponsive to stimuli 14.56 9.89 93 94130 33723 63361076
Injection site rash 14.32 9.89 5 94218 18804 63375995
Haemoptysis 14.28 9.89 82 94141 28644 63366155
Tremor 14.06 9.89 275 93948 131964 63262835
Enterocolitis 14.05 9.89 34 94189 7824 63386975
Malnutrition 13.80 9.89 52 94171 15246 63379553
Lymphocyte count decreased 13.52 9.89 84 94139 30173 63364626
Premature baby 13.41 9.89 7 94216 20728 63374071
Full blood count decreased 13.40 9.89 75 94148 25949 63368850
Pruritus 13.01 9.89 423 93800 361030 63033769
Bronchial artery embolisation 12.94 9.89 3 94220 7 63394792
Atrial fibrillation 12.89 9.89 244 93979 116392 63278407
Neuralgia 12.88 9.89 74 94149 25852 63368947
Hepatic enzyme increased 12.83 9.89 217 94006 202111 63192688
Thrombocytopenia 12.75 9.89 304 93919 150853 63243946
Colitis ulcerative 12.67 9.89 12 94211 26079 63368720
Radiation associated pain 12.64 9.89 5 94218 97 63394702
Vision blurred 12.58 9.89 199 94024 91725 63303074
Parkinson's disease 12.52 9.89 12 94211 1207 63393592
Joint range of motion decreased 12.43 9.89 18 94205 32410 63362389
Premature delivery 12.42 9.89 16 94207 30265 63364534
Fatigue 12.35 9.89 1501 92722 886527 62508272
Basal cell carcinoma 12.32 9.89 14 94209 27977 63366822
Onychoclasis 12.30 9.89 28 94195 6194 63388605
Nasal discharge discolouration 12.29 9.89 16 94207 2255 63392544
Gingival pain 12.19 9.89 33 94190 8129 63386670
Blood loss anaemia 12.07 9.89 35 94188 8966 63385833
Sputum discoloured 11.91 9.89 52 94171 16295 63378504
Injection site bruising 11.86 9.89 28 94195 41882 63352917
Medication error 11.77 9.89 39 94184 52245 63342554
Chest pain 11.76 9.89 411 93812 215548 63179251
Small cell lung cancer extensive stage 11.73 9.89 3 94220 12 63394787
Arteriovenous graft site infection 11.73 9.89 3 94220 12 63394787
Postural tremor 11.71 9.89 7 94216 344 63394455
Injection site warmth 11.64 9.89 4 94219 15191 63379608
Postmenopausal haemorrhage 11.45 9.89 15 94208 2127 63392672
Hypoalbuminaemia 11.38 9.89 41 94182 11764 63383035
Product dose omission issue 11.32 9.89 263 93960 234050 63160749
Acquired epidermolysis bullosa 11.31 9.89 4 94219 56 63394743
Catheter site pain 11.30 9.89 23 94200 4712 63390087
Nasopharyngitis 11.30 9.89 289 93934 253968 63140831
Anaphylactic reaction 11.28 9.89 55 94168 66045 63328754
Cholecystitis 11.27 9.89 49 94174 15328 63379471
Heart rate decreased 11.16 9.89 110 94113 45450 63349349
Impaired work ability 11.15 9.89 6 94217 17469 63377330
Wrong technique in product usage process 11.15 9.89 51 94172 62289 63332510
Sleep disorder 11.14 9.89 73 94150 81493 63313306
Urinary tract obstruction 11.10 9.89 15 94208 2193 63392606
Flank pain 11.05 9.89 51 94172 16359 63378440
Embolic stroke 11.05 9.89 20 94203 3756 63391043
Joint stiffness 11.04 9.89 29 94194 41840 63352959
Non-Hodgkin's lymphoma 11.04 9.89 12 94211 1400 63393399
Cystocele 10.86 9.89 11 94212 1183 63393616
Gastrointestinal injury 10.80 9.89 8 94215 564 63394235
Product prescribing error 10.67 9.89 14 94209 26275 63368524
Blood thyroid stimulating hormone increased 10.66 9.89 29 94194 7165 63387634
Limb crushing injury 10.60 9.89 6 94217 266 63394533
COVID-19 10.56 9.89 112 94111 112991 63281808
Large intestinal obstruction 10.52 9.89 15 94208 2304 63392495
Insulin C-peptide increased 10.49 9.89 4 94219 70 63394729
Rubber sensitivity 10.46 9.89 15 94208 2316 63392483
Pruritus genital 10.37 9.89 16 94207 2638 63392161
White blood cell count increased 10.36 9.89 114 94109 48447 63346352
Muscular weakness 10.30 9.89 246 93977 122107 63272692
Wound infection bacterial 10.29 9.89 8 94215 606 63394193
Gastric ulcer 10.29 9.89 66 94157 23971 63370828
Pulmonary hypertension 10.27 9.89 92 94131 37031 63357768
Urinary retention postoperative 10.24 9.89 4 94219 75 63394724
Retching 10.23 9.89 46 94177 14599 63380200
Hypokalaemia 10.08 9.89 213 94010 103591 63291208
Intracranial hypotension 9.98 9.89 6 94217 298 63394501
Pharyngeal mass 9.96 9.89 6 94217 299 63394500

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 226.35 10.44 295 62548 456456 34437632
Off label use 163.10 10.44 318 62525 419206 34474882
Constipation 143.01 10.44 555 62288 136427 34757661
Drug abuse 108.26 10.44 23 62820 99073 34795015
Completed suicide 106.80 10.44 23 62820 98145 34795943
Plasma cell myeloma 86.57 10.44 216 62627 41821 34852267
Pneumonia 80.74 10.44 1000 61843 361627 34532461
Dehydration 79.63 10.44 451 62392 129518 34764570
Drug interaction 76.88 10.44 184 62659 225762 34668326
Product use in unapproved indication 65.19 10.44 69 62774 117430 34776658
Toxicity to various agents 57.71 10.44 177 62666 200185 34693903
Mental status changes 56.85 10.44 174 62669 37909 34856179
Soft tissue mass 47.48 10.44 27 62816 992 34893096
Multimorbidity 46.71 10.44 26 62817 916 34893172
Febrile neutropenia 46.67 10.44 412 62431 136437 34757651
Oesophageal perforation 45.96 10.44 28 62815 1171 34892917
Pleural effusion 44.73 10.44 275 62568 81271 34812817
Intentional overdose 44.01 10.44 12 62831 43662 34850426
Dysphagia 43.22 10.44 224 62619 62157 34831931
Urinary tract infection 42.67 10.44 278 62565 83803 34810285
Fall 42.17 10.44 553 62290 202332 34691756
Decreased appetite 41.74 10.44 470 62373 165922 34728166
Platelet count decreased 41.11 10.44 361 62482 119356 34774732
Condition aggravated 40.90 10.44 192 62651 192004 34702084
Haemoglobin decreased 38.31 10.44 358 62485 120414 34773674
White blood cell count increased 38.24 10.44 161 62682 40990 34853098
Confusional state 36.04 10.44 407 62436 143753 34750335
Foetal exposure during pregnancy 35.62 10.44 12 62831 38089 34855999
Malignant neoplasm progression 35.30 10.44 275 62568 87771 34806317
Superinfection 35.11 10.44 32 62811 2487 34891601
Treatment failure 33.88 10.44 21 62822 46676 34847412
Failure to thrive 32.84 10.44 57 62786 8544 34885544
Pneumonia aspiration 30.79 10.44 153 62690 41750 34852338
Haematocrit decreased 30.67 10.44 127 62716 32089 34861999
Muscular weakness 30.50 10.44 230 62613 72667 34821421
Disease progression 29.70 10.44 311 62532 107766 34786322
Overdose 27.94 10.44 78 62765 90981 34803107
Cholestasis 27.92 10.44 7 62836 26941 34867147
Transplant failure 25.96 10.44 32 62811 3521 34890567
Deep vein thrombosis 25.70 10.44 203 62640 65045 34829043
Contraindicated product administered 25.56 10.44 4 62839 21477 34872611
Product dose omission issue 25.19 10.44 120 62723 119591 34774497
Urinary retention 24.91 10.44 130 62713 36158 34857930
Hepatocellular injury 24.55 10.44 5 62838 22206 34871882
Metastatic renal cell carcinoma 24.55 10.44 24 62819 2037 34892051
Ileus 24.25 10.44 75 62768 16424 34877664
Neutrophil count decreased 24.12 10.44 166 62677 50938 34843150
White blood cell count decreased 23.61 10.44 269 62574 95176 34798912
Lung consolidation 23.53 10.44 40 62803 5896 34888192
Pneumonitis 23.00 10.44 121 62722 33757 34860331
Hallucination 22.97 10.44 165 62678 51333 34842755
Drug hypersensitivity 22.52 10.44 72 62771 80457 34813631
Drug reaction with eosinophilia and systemic symptoms 22.39 10.44 16 62827 32996 34861092
Hypoxia 22.02 10.44 172 62671 54923 34839165
Neurogenic bladder 21.39 10.44 21 62822 1792 34892296
Red blood cell count decreased 21.21 10.44 106 62737 28984 34865104
Cardiac failure congestive 20.73 10.44 235 62608 83035 34811053
Asthenia 20.66 10.44 582 62261 244669 34649419
Therapeutic product effect incomplete 20.64 10.44 37 62806 50504 34843584
Rheumatoid arthritis 20.58 10.44 23 62820 38215 34855873
Suicide attempt 20.54 10.44 24 62819 39092 34854996
Pulmonary vasculitis 20.46 10.44 13 62830 586 34893502
Burkholderia test positive 20.45 10.44 16 62827 1007 34893081
Intentional product misuse 19.91 10.44 32 62811 45579 34848509
Neuritis 19.53 10.44 15 62828 919 34893169
Granulocytopenia 19.42 10.44 39 62804 6528 34887560
Atelectasis 19.39 10.44 73 62770 17654 34876434
Pathological fracture 19.30 10.44 31 62812 4360 34889728
Premature baby 18.67 10.44 6 62837 19627 34874461
Hypophagia 18.56 10.44 89 62754 23933 34870155
Decubitus ulcer 18.52 10.44 46 62797 8875 34885213
Intentional product use issue 18.51 10.44 51 62792 59765 34834323
Sepsis 18.38 10.44 410 62433 166151 34727937
Multiple organ dysfunction syndrome 18.38 10.44 73 62770 76493 34817595
Back pain 17.52 10.44 312 62531 121477 34772611
Subacute endocarditis 17.15 10.44 6 62837 66 34894022
Pulmonary embolism 17.10 10.44 241 62602 89505 34804583
Immunosuppressant drug level increased 16.77 10.44 35 62808 6020 34888068
Drug ineffective for unapproved indication 16.74 10.44 11 62832 23704 34870384
Eosinophil percentage increased 16.38 10.44 11 62832 545 34893543
Neutrophil count increased 15.85 10.44 67 62776 17079 34877009
Disturbance in attention 15.80 10.44 14 62829 25931 34868157
Injection site pain 15.53 10.44 29 62814 38976 34855112
Oral pustule 15.45 10.44 8 62835 243 34893845
Blood sodium decreased 15.41 10.44 64 62779 16187 34877901
Death 15.38 10.44 868 61975 397181 34496907
Lumbar spinal stenosis 15.34 10.44 21 62822 2561 34891527
Toxic epidermal necrolysis 15.33 10.44 10 62833 21636 34872452
Metabolic acidosis 15.26 10.44 35 62808 43645 34850443
Dyspnoea paroxysmal nocturnal 15.20 10.44 16 62827 1483 34892605
Stupor 14.94 10.44 22 62821 2869 34891219
Myelosuppression 14.92 10.44 8 62835 19257 34874831
Delirium 14.73 10.44 132 62711 43859 34850229
Product use issue 14.71 10.44 61 62782 63155 34830933
Angioedema 14.69 10.44 28 62815 37346 34856742
Hospice care 14.63 10.44 36 62807 6904 34887184
Fatigue 14.45 10.44 809 62034 369844 34524244
Streptococcus test positive 14.35 10.44 13 62830 1002 34893086
Biliary obstruction 14.35 10.44 21 62822 2724 34891364
Wrong technique in product usage process 14.11 10.44 27 62816 35959 34858129
Synovitis 13.91 10.44 4 62839 14062 34880026
Water intoxication 13.90 10.44 9 62834 419 34893669
Cancer pain 13.33 10.44 20 62823 2652 34891436
Cholangitis 13.24 10.44 40 62803 8649 34885439
Psoriatic arthropathy 12.90 10.44 10 62833 19788 34874300
Lactic acidosis 12.85 10.44 27 62816 34745 34859343
Eosinophilia 12.81 10.44 17 62826 26205 34867883
Cellulitis 12.53 10.44 148 62695 52803 34841285
Calculus bladder 12.46 10.44 12 62831 1000 34893088
Cardiogenic shock 12.26 10.44 18 62825 26600 34867488
Peritonitis bacterial 12.15 10.44 31 62812 6079 34888009
Spinal compression fracture 12.03 10.44 34 62809 7082 34887006
Polyneuropathy 11.81 10.44 6 62837 14890 34879198
Oesophageal carcinoma 11.61 10.44 40 62803 9264 34884824
Unresponsive to stimuli 11.53 10.44 87 62756 27482 34866606
Withdrawal syndrome 11.50 10.44 4 62839 12451 34881637
Faecaloma 11.45 10.44 28 62815 5349 34888739
Radiation skin injury 11.44 10.44 10 62833 735 34893353
Small intestinal obstruction 11.43 10.44 55 62788 14811 34879277
Band neutrophil percentage increased 11.31 10.44 5 62838 106 34893982
Full blood count decreased 11.19 10.44 63 62780 18025 34876063
Haemoptysis 11.19 10.44 104 62739 34902 34859186
Paratracheal lymphadenopathy 11.18 10.44 5 62838 109 34893979
Urticaria 11.17 10.44 66 62777 62311 34831777
Monocyte percentage increased 11.01 10.44 11 62832 958 34893130
COVID-19 10.95 10.44 88 62755 77462 34816626
Vomiting 10.94 10.44 547 62296 247074 34647014
Dextrocardia 10.85 10.44 5 62838 117 34893971
Muscle spasticity 10.82 10.44 29 62814 5859 34888229
Incorrect dose administered 10.79 10.44 37 62806 40478 34853610
Radiation pneumonitis 10.74 10.44 18 62825 2622 34891466
Coma 10.67 10.44 44 62799 45634 34848454
Blood calcium decreased 10.59 10.44 41 62802 10043 34884045
Pyrexia 10.57 10.44 714 62129 332299 34561789
Inflammatory marker increased 10.51 10.44 26 62817 5002 34889086

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 420.71 9.93 674 126434 1080239 78537041
Constipation 371.63 9.93 1142 125966 281908 79335372
Completed suicide 221.49 9.93 59 127049 245708 79371572
Temperature regulation disorder 216.60 9.93 128 126980 5725 79611555
Off label use 212.27 9.93 740 126368 906475 78710805
Plasma cell myeloma 177.90 9.93 311 126797 52948 79564332
Pneumonia aspiration 176.19 9.93 353 126755 66614 79550666
Synovitis 170.73 9.93 20 127088 150714 79466566
Food allergy 164.17 9.93 137 126971 10687 79606593
Systemic lupus erythematosus 147.89 9.93 12 127096 121137 79496143
Hand deformity 146.85 9.93 4 127104 103915 79513365
Toxicity to various agents 146.55 9.93 281 126827 421259 79196021
Coeliac disease 140.57 9.93 128 126980 11223 79606057
Dehydration 136.97 9.93 767 126341 247420 79369860
Pemphigus 129.97 9.93 7 127101 99575 79517705
Drug interaction 129.78 9.93 294 126814 414889 79202391
Pneumonia 124.31 9.93 1601 125507 658645 78958635
Mental status changes 123.19 9.93 306 126802 66653 79550627
Therapeutic product effect decreased 117.59 9.93 57 127051 163806 79453474
Febrile neutropenia 117.07 9.93 698 126410 230301 79386979
Drug intolerance 116.48 9.93 150 126958 263969 79353311
Arthropathy 112.10 9.93 72 127036 177039 79440241
Drug abuse 111.65 9.93 60 127048 162631 79454649
Pulmonary embolism 110.75 9.93 554 126554 171100 79446180
Immunodeficiency 107.29 9.93 152 126956 21616 79595664
Condition aggravated 104.89 9.93 427 126681 500697 79116583
Maternal exposure during pregnancy 103.41 9.93 44 127064 136494 79480786
Joint swelling 103.23 9.93 189 126919 288457 79328823
Fluid retention 103.06 9.93 294 126814 69515 79547765
Pleural effusion 102.45 9.93 481 126627 144781 79472499
Platelet count decreased 99.10 9.93 589 126519 194075 79423205
Discomfort 97.53 9.93 39 127069 125578 79491702
Gastrooesophageal reflux disease 96.57 9.93 375 126733 103871 79513409
Treatment failure 94.06 9.93 80 127028 170406 79446874
Deep vein thrombosis 93.16 9.93 411 126697 120508 79496772
Back pain 92.51 9.93 813 126295 303367 79313913
Alopecia 86.76 9.93 147 126961 231208 79386072
Haemoglobin decreased 85.68 9.93 627 126481 221492 79395788
Duodenal ulcer perforation 85.33 9.93 5 127103 66206 79551074
Helicobacter infection 84.80 9.93 7 127101 69697 79547583
Product use in unapproved indication 80.83 9.93 174 126934 250185 79367095
Intentional overdose 80.47 9.93 34 127074 105926 79511354
Glossodynia 80.35 9.93 32 127076 103305 79513975
Salpingo-oophorectomy unilateral 74.32 9.93 33 127075 801 79616479
Arthralgia 73.87 9.93 571 126537 571232 79046048
Psoriatic arthropathy 73.55 9.93 17 127091 77982 79539298
Failure to thrive 72.61 9.93 92 127016 11752 79605528
Malignant neoplasm progression 72.10 9.93 416 126692 135574 79481706
Upper respiratory tract infection 71.06 9.93 311 126797 90857 79526423
Ileus 68.71 9.93 138 126970 26073 79591207
Pericarditis 67.84 9.93 41 127067 104195 79513085
Oesophageal spasm 63.61 9.93 49 127059 3407 79613873
Neutrophil count decreased 63.22 9.93 307 126801 93652 79523628
Folliculitis 61.09 9.93 8 127100 55372 79561908
Respiratory symptom 59.27 9.93 54 127054 4737 79612543
Bursitis 58.88 9.93 157 126951 35687 79581593
Urinary tract infection 58.48 9.93 682 126426 273830 79343450
Eosinophil percentage increased 58.28 9.93 34 127074 1484 79615796
Hyperhidrosis 56.31 9.93 424 126684 151068 79466212
Rash erythematous 56.10 9.93 211 126897 57558 79559722
Muscle injury 56.08 9.93 6 127102 48555 79568725
Sinusitis fungal 55.77 9.93 39 127069 2335 79614945
Intentional product use issue 55.77 9.93 98 127010 152014 79465266
Oesophageal pain 54.45 9.93 49 127059 4230 79613050
Hypoxia 52.88 9.93 313 126795 102930 79514350
Decreased appetite 52.72 9.93 802 126306 341616 79275664
White blood cell count decreased 51.96 9.93 493 126615 187795 79429485
Dysphagia 51.86 9.93 353 126755 121783 79495497
Granulocytopenia 50.78 9.93 76 127032 11355 79605925
Oedema peripheral 50.74 9.93 620 126488 251668 79365612
Irritable bowel syndrome 50.51 9.93 18 127090 62223 79555057
Inflammation 50.47 9.93 45 127063 93708 79523572
Wound 50.12 9.93 67 127041 116112 79501168
Hepatocellular injury 49.88 9.93 8 127100 47585 79569695
Drug resistance 49.30 9.93 5 127103 42208 79575072
Therapeutic product effect incomplete 48.60 9.93 95 127013 141550 79475730
Therapeutic response decreased 46.81 9.93 24 127084 66829 79550451
Hiatus hernia 46.56 9.93 110 126998 23202 79594078
Contraindicated product administered 46.37 9.93 115 126993 157423 79459857
Peritonitis bacterial 45.96 9.93 66 127042 9501 79607779
Soft tissue mass 44.62 9.93 27 127081 1261 79616019
Oesophageal perforation 44.54 9.93 29 127079 1542 79615738
Hallucination 43.94 9.93 260 126848 85485 79531795
Sputum increased 43.88 9.93 45 127063 4568 79612712
Embolism venous 43.34 9.93 43 127065 4196 79613084
White blood cell count increased 42.65 9.93 233 126875 74400 79542880
Haematocrit decreased 42.44 9.93 202 126906 61110 79556170
Cholestasis 42.41 9.93 15 127093 52094 79565186
Suicide attempt 42.07 9.93 42 127066 82890 79534390
Drug reaction with eosinophilia and systemic symptoms 40.78 9.93 26 127082 64218 79553062
Disease progression 40.10 9.93 460 126648 183902 79433378
Product use issue 39.99 9.93 185 126923 209637 79407643
Musculoskeletal stiffness 39.81 9.93 144 126964 174864 79442416
Multimorbidity 39.42 9.93 26 127082 1413 79615867
Exposure during pregnancy 39.05 9.93 63 127045 101069 79516211
Abdominal discomfort 38.39 9.93 238 126870 250489 79366791
Cestode infection 38.27 9.93 15 127093 263 79617017
Fall 38.07 9.93 1032 126076 486597 79130683
Gastrointestinal disorder 37.71 9.93 87 127021 122118 79495162
Female genital tract fistula 37.56 9.93 47 127061 5928 79611352
Blood cholesterol increased 36.39 9.93 48 127060 83672 79533608
Carbohydrate antigen 125 increased 35.96 9.93 29 127079 2155 79615125
Cardiac failure congestive 35.92 9.93 366 126742 142036 79475244
Small intestinal obstruction 35.61 9.93 110 126998 27162 79590118
Asthma 35.42 9.93 350 126758 134745 79482535
General physical health deterioration 35.37 9.93 275 126833 274963 79342317
Blood sodium decreased 35.26 9.93 125 126983 33130 79584150
Diverticulum 35.02 9.93 75 127033 14821 79602459
Blood uric acid decreased 34.63 9.93 23 127085 1265 79616015
Diastolic dysfunction 34.62 9.93 62 127046 10749 79606531
Death 34.55 9.93 1163 125945 565351 79051929
Total lung capacity decreased 34.49 9.93 32 127076 2873 79614407
Impaired healing 34.41 9.93 54 127054 87601 79529679
Sepsis 34.01 9.93 611 126497 268817 79348463
Asthenia 33.66 9.93 1060 126048 510629 79106651
Anaemia 33.36 9.93 937 126171 444078 79173202
Iron deficiency anaemia 33.02 9.93 103 127005 25569 79591711
Lung opacity 33.00 9.93 41 127067 5133 79612147
Red blood cell sedimentation rate increased 32.91 9.93 16 127092 45926 79571354
Hypophagia 32.52 9.93 151 126957 45216 79572064
Infection 32.24 9.93 239 126869 241473 79375807
Liver injury 31.90 9.93 26 127082 56588 79560692
Sleep apnoea syndrome 31.17 9.93 128 126980 36350 79580930
Chronic sinusitis 31.10 9.93 66 127042 12960 79604320
Injection site reaction 31.07 9.93 25 127083 54760 79562520
Knee arthroplasty 31.07 9.93 15 127093 43233 79574047
Premenstrual syndrome 30.91 9.93 16 127092 550 79616730
Injection site pain 30.75 9.93 105 127003 129733 79487547
Spinal compression fracture 30.65 9.93 77 127031 16881 79600399
Swelling 30.49 9.93 211 126897 216500 79400780
Fungal infection 29.95 9.93 139 126969 41609 79575671
Red blood cell count decreased 29.85 9.93 175 126933 57338 79559942
Muscular weakness 29.73 9.93 389 126719 160340 79456940
Pneumonitis 29.55 9.93 182 126926 60678 79556602
Bronchopulmonary aspergillosis allergic 29.37 9.93 30 127078 3031 79614249
Cellulitis 29.29 9.93 284 126824 108776 79508504
Rheumatoid arthritis 28.83 9.93 204 126904 208266 79409014
Drug ineffective for unapproved indication 28.29 9.93 24 127084 51214 79566066
Drug hypersensitivity 27.99 9.93 323 126785 298593 79318687
Respiratory failure 27.89 9.93 424 126684 180487 79436793
Blood creatinine decreased 27.83 9.93 47 127061 7778 79609502
International normalised ratio increased 27.55 9.93 230 126878 84491 79532789
Blood calcium increased 27.55 9.93 55 127053 10345 79606935
Accidental exposure to product 27.28 9.93 8 127100 31314 79585966
Intentional self-injury 26.95 9.93 9 127099 32410 79584870
Haemoptysis 26.90 9.93 167 126941 55832 79561448
Magnesium deficiency 26.70 9.93 15 127093 609 79616671
Therapy non-responder 26.67 9.93 68 127040 92237 79525043
Urinary retention 26.65 9.93 168 126940 56462 79560818
Injection site erythema 26.34 9.93 53 127055 78144 79539136
Nasal polyps 26.05 9.93 44 127064 7283 79609997
Haemorrhoids 25.51 9.93 103 127005 29025 79588255
Emphysema 25.37 9.93 70 127038 16230 79601050
Abdominal distension 25.32 9.93 297 126811 119353 79497927
Aspiration 25.12 9.93 80 127028 20078 79597202
Lichen sclerosus 24.93 9.93 17 127091 977 79616303
Mobility decreased 24.91 9.93 105 127003 122070 79495210
Polymenorrhoea 24.80 9.93 17 127091 985 79616295
Neurogenic bladder 24.69 9.93 32 127076 4180 79613100
Myelosuppression 24.64 9.93 17 127091 40279 79577001
Metabolic acidosis 24.47 9.93 60 127048 82469 79534811
Decubitus ulcer 24.05 9.93 67 127041 15620 79601660
Rales 23.68 9.93 78 127030 19923 79597357
Product dose omission issue 22.97 9.93 268 126840 247269 79370011
Somnolence 22.84 9.93 520 126588 238461 79378819
Hepatotoxicity 22.77 9.93 29 127079 51323 79565957
Obstructive airways disorder 22.76 9.93 105 127003 31354 79585926
Cystitis 22.72 9.93 153 126955 52579 79564701
Injection site swelling 22.63 9.93 25 127083 47107 79570173
Metastatic renal cell carcinoma 22.45 9.93 23 127085 2332 79614948
Lung consolidation 22.14 9.93 46 127062 8901 79608379
Vomiting 22.08 9.93 1284 125824 664544 78952736
Injection site pruritus 21.92 9.93 21 127087 42262 79575018
Abdominal pain 21.52 9.93 791 126317 388778 79228502
Lip pruritus 21.46 9.93 15 127093 897 79616383
Pulmonary vasculitis 21.46 9.93 14 127094 747 79616533
Hysterectomy 21.42 9.93 37 127071 6235 79611045
Pregnancy 21.39 9.93 8 127100 26843 79590437
Chronic obstructive pulmonary disease 21.27 9.93 219 126889 85200 79532080
Lymphoedema 21.02 9.93 55 127053 12358 79604922
Hospice care 20.93 9.93 49 127059 10275 79607005
Pyrexia 20.84 9.93 1300 125808 677409 78939871
Transplant failure 20.82 9.93 31 127077 4610 79612670
Atelectasis 20.69 9.93 104 127004 32153 79585127
Ecchymosis 20.48 9.93 62 127046 15144 79602136
Dental restoration failure 20.44 9.93 15 127093 969 79616311
Gastrointestinal haemorrhage 20.42 9.93 340 126768 147379 79469901
Fatigue 20.41 9.93 1733 125375 927994 78689286
Lymphocyte count decreased 20.25 9.93 137 126971 47152 79570128
Grip strength decreased 20.15 9.93 5 127103 21864 79595416
Adverse drug reaction 19.89 9.93 48 127060 66344 79550936
Interstitial lung disease 19.77 9.93 270 126838 112330 79504950
Superinfection 19.54 9.93 31 127077 4871 79612409
Multiple organ dysfunction syndrome 19.52 9.93 112 126996 120134 79497146
Menstruation delayed 19.48 9.93 17 127091 1409 79615871
Wrong technique in product usage process 19.41 9.93 57 127051 73818 79543462
Tricuspid valve incompetence 19.13 9.93 72 127036 19640 79597640
Unresponsive to stimuli 18.97 9.93 153 126955 55635 79561645
C-reactive protein increased 18.95 9.93 124 126984 128903 79488377
Hip fracture 18.91 9.93 98 127010 30663 79586617
Nausea 18.83 9.93 1770 125338 955426 78661854
Medication error 18.74 9.93 52 127056 68590 79548690
Radiation pneumonitis 18.70 9.93 27 127081 3906 79613374
Arthritis 18.65 9.93 107 127001 114773 79502507
Abortion spontaneous 18.65 9.93 12 127096 29495 79587785
Device expulsion 18.53 9.93 9 127099 25852 79591428
Blister 18.48 9.93 113 126995 119363 79497917
Sputum discoloured 18.34 9.93 76 127032 21667 79595613
Colitis ulcerative 18.31 9.93 17 127091 34725 79582555
Cancer pain 17.99 9.93 31 127077 5214 79612066
Lactic acidosis 17.97 9.93 55 127053 70304 79546976
Live birth 17.84 9.93 4 127104 18740 79598540
COVID-19 17.78 9.93 163 126945 157511 79459769
Neutrophil count increased 17.62 9.93 93 127015 29303 79587977
Neuralgia 17.59 9.93 102 127006 33282 79583998
Type 2 diabetes mellitus 17.35 9.93 41 127067 57081 79560199
Injection site bruising 17.32 9.93 24 127084 40978 79576302
Acute respiratory failure 16.95 9.93 157 126951 59384 79557896
Enterocolitis 16.65 9.93 56 127052 14456 79602824
Malignant neoplasm of thorax 16.50 9.93 4 127104 11 79617269
Postmenopausal haemorrhage 16.34 9.93 16 127092 1536 79615744
Hepatic function abnormal 16.14 9.93 183 126925 72924 79544356
Sleep disorder 16.04 9.93 76 127032 85601 79531679
Ill-defined disorder 15.78 9.93 53 127055 65822 79551458
Hyperaesthesia 15.68 9.93 49 127059 12173 79605107
Hypervolaemia 15.57 9.93 119 126989 42571 79574709
Coma 15.54 9.93 236 126872 100413 79516867
Agitation 15.47 9.93 234 126874 99481 79517799
Malnutrition 15.47 9.93 74 127034 22428 79594852
Product prescribing error 15.41 9.93 30 127078 44783 79572497
Nasopharyngitis 15.23 9.93 299 126809 253582 79363698
Polyneuropathy 15.02 9.93 10 127098 24141 79593139
Blood creatinine increased 14.99 9.93 338 126770 154719 79462561
Retching 14.69 9.93 61 127047 17406 79599874
Basal cell carcinoma 14.69 9.93 23 127085 37352 79579928
Hypokalaemia 14.56 9.93 316 126792 143724 79473556
Haemorrhage intracranial 14.44 9.93 81 127027 26112 79591168
Ascites 14.43 9.93 184 126924 75378 79541902
Toxic epidermal necrolysis 14.35 9.93 31 127077 44550 79572730
Water intoxication 14.30 9.93 11 127097 763 79616517
Lethargy 14.30 9.93 195 126913 81097 79536183
Anaphylactic shock 14.29 9.93 22 127086 35974 79581306
Poriomania 14.25 9.93 7 127101 215 79617065
Adverse event 14.04 9.93 49 127059 60165 79557115
Upper respiratory tract inflammation 14.04 9.93 24 127084 4011 79613269
Sinusitis 14.03 9.93 223 126885 195278 79422002
Blood potassium decreased 13.93 9.93 124 126984 46388 79570892
Loss of personal independence in daily activities 13.87 9.93 101 127007 102479 79514801
Eosinophil count increased 13.81 9.93 59 127049 17046 79600234
Poisoning 13.75 9.93 12 127096 25260 79592020
Myalgia 13.58 9.93 211 126897 185430 79431850
Blood urea increased 13.56 9.93 128 126980 48662 79568618
Haematotoxicity 13.45 9.93 4 127104 15515 79601765
Urticaria 13.38 9.93 211 126897 184990 79432290
Joint effusion 13.32 9.93 6 127102 18008 79599272
Lip dry 13.32 9.93 4 127104 15414 79601866
Delirium 13.29 9.93 199 126909 84428 79532852
Stupor 13.26 9.93 32 127076 6840 79610440
Dyspnoea paroxysmal nocturnal 13.17 9.93 17 127091 2211 79615069
Serotonin syndrome 13.14 9.93 33 127075 44994 79572286
Hip arthroplasty 13.13 9.93 23 127085 35733 79581547
Rubber sensitivity 13.03 9.93 15 127093 1734 79615546
Neuritis 12.97 9.93 15 127093 1743 79615537
Pneumonia viral 12.96 9.93 38 127070 9120 79608160
Heart rate increased 12.90 9.93 267 126841 120457 79496823
Lumbar spinal stenosis 12.88 9.93 27 127081 5255 79612025
Perirectal abscess 12.74 9.93 16 127092 2025 79615255
Oral pustule 12.69 9.93 7 127101 274 79617006
Spinal cord compression 12.64 9.93 30 127078 6347 79610933
Posterior reversible encephalopathy syndrome 12.55 9.93 14 127094 26267 79591013
Intestinal obstruction 12.53 9.93 114 126994 42906 79574374
Blood thyroid stimulating hormone increased 12.53 9.93 39 127069 9669 79607611
Injection site warmth 12.50 9.93 4 127104 14803 79602477
Acute generalised exanthematous pustulosis 12.37 9.93 6 127102 17248 79600032
Calculus bladder 12.36 9.93 13 127095 1359 79615921
Cardiomegaly 12.29 9.93 78 127030 26274 79591006
Airway burns 12.19 9.93 3 127105 9 79617271
Monocyte percentage increased 12.14 9.93 16 127092 2125 79615155
Tremor 12.12 9.93 356 126752 169727 79447553
Pruritus 12.11 9.93 510 126598 394138 79223142
Blood creatine phosphokinase decreased 12.10 9.93 11 127097 962 79616318
Impaired quality of life 11.95 9.93 4 127104 14382 79602898
Anxiety 11.92 9.93 497 126611 248015 79369265
Faecaloma 11.86 9.93 43 127065 11521 79605759
Faecal volume increased 11.78 9.93 7 127101 316 79616964
Intentional product misuse 11.78 9.93 96 127012 95069 79522211
Angioedema 11.71 9.93 72 127036 75963 79541317
Tinnitus 11.68 9.93 115 126993 44218 79573062
Bronchopulmonary aspergillosis 11.64 9.93 11 127097 22283 79594997
Non-small cell lung cancer 11.62 9.93 29 127079 6331 79610949
Dyspnoea 11.62 9.93 1547 125561 855478 78761802
Dyspnoea exertional 11.51 9.93 199 126909 86874 79530406
Pneumothorax 11.50 9.93 81 127027 28242 79589038
Illness 11.43 9.93 37 127071 46474 79570806
Otorrhoea 11.41 9.93 14 127094 1731 79615549
Compression fracture 11.33 9.93 29 127079 6431 79610849
Cardiogenic shock 11.26 9.93 32 127076 41882 79575398
Lupus-like syndrome 11.25 9.93 4 127104 13853 79603427
Radiation associated pain 11.20 9.93 5 127103 123 79617157
Cholecystitis chronic 11.16 9.93 38 127070 9868 79607412
Impaired work ability 11.14 9.93 9 127099 19672 79597608
Peripheral swelling 11.10 9.93 336 126772 269281 79347999
Lower gastrointestinal haemorrhage 11.06 9.93 53 127055 16072 79601208
Cholangitis 11.05 9.93 45 127063 12731 79604549
Foetal death 11.02 9.93 33 127075 8011 79609269
Malignant neoplasm of renal pelvis 10.98 9.93 5 127103 129 79617151
Ankylosing spondylitis 10.85 9.93 3 127105 12202 79605078
Accidental overdose 10.79 9.93 30 127078 39551 79577729
Productive cough 10.66 9.93 199 126909 88132 79529148
Pathological fracture 10.65 9.93 39 127069 10498 79606782
Bladder catheterisation 10.63 9.93 10 127098 914 79616366
Embolic stroke 10.62 9.93 32 127076 7794 79609486
Blood test abnormal 10.59 9.93 56 127052 17654 79599626
Immunosuppressant drug level increased 10.50 9.93 35 127073 8992 79608288
Cytomegalovirus infection 10.42 9.93 34 127074 42610 79574670
Bronchial artery embolisation 10.38 9.93 3 127105 19 79617261
Phlebosclerosis 10.35 9.93 5 127103 148 79617132
Dementia 10.29 9.93 71 127037 24588 79592692
Catheter site pain 10.28 9.93 25 127083 5371 79611909
Venoocclusive liver disease 10.26 9.93 3 127105 11768 79605512
Hyponatraemia 10.26 9.93 363 126745 177485 79439795
Small cell lung cancer extensive stage 10.25 9.93 3 127105 20 79617260
Respiratory tract congestion 10.24 9.93 10 127098 19944 79597336
Ear infection 10.23 9.93 25 127083 34407 79582873
Gastrointestinal perforation 10.20 9.93 27 127081 6110 79611170
Nasal discharge discolouration 10.13 9.93 16 127092 2505 79614775
Gastrointestinal injury 10.10 9.93 10 127098 973 79616307
Bacteraemia 10.08 9.93 88 127020 32736 79584544
Feeling hot 10.04 9.93 55 127053 59679 79557601
Hiccups 10.04 9.93 37 127071 9994 79607286

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Irritable bowel syndrome off-label use 10743008 DOID:9778
Incomplete passage of stool off-label use 249515001
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Intestinal obstruction contraindication 81060008 DOID:8437
Gastrointestinal obstruction contraindication 126765001
Intestinal Impaction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021246 VUID
N0000179238 NUI
62211-03-4 SECONDARY_CAS_RN
4019930 VANDF
4021246 VANDF
C3489575 UMLSCUI
CHEMBL2108559 ChEMBL_ID
DB11365 DRUGBANK_ID
3FYP5M0IJX UNII
5199 PUBCHEM_CID
36387 RXNORM
5149 MMSL
5452 MMSL
5455 MMSL
84266 MMSL
d01013 MMSL
001169 NDDF
001170 NDDF
003868 NDDF
30125007 SNOMEDCT_US
387162007 SNOMEDCT_US
412302003 SNOMEDCT_US
420709001 SNOMEDCT_US
D000081226 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-0003 PILL 15 mg ORAL OTC monograph not final 16 sections
EX-LAXREGULAR STRENGTH CHOCOLATED STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8140 TABLET, CHEWABLE 15 mg ORAL OTC monograph not final 15 sections
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8141 TABLET 15 mg ORAL OTC monograph not final 16 sections
EX-LAXMAXIMUM STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8142 PILL 25 mg ORAL OTC monograph not final 16 sections
Perdiem HUMAN OTC DRUG LABEL 1 0067-8143 TABLET 15 mg ORAL OTC monograph not final 15 sections
Senna Syrup HUMAN OTC DRUG LABEL 1 0121-4967 LIQUID 8.80 mg ORAL OTC monograph not final 11 sections
Senna Syrup HUMAN OTC DRUG LABEL 1 0121-4967 LIQUID 8.80 mg ORAL OTC monograph not final 11 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0138 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0138 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
LaxativeRegular Strength HUMAN OTC DRUG LABEL 1 0363-0347 TABLET, COATED 15 mg ORAL OTC monograph not final 16 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0486 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0486 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0785 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0785 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener LaxativePlus Stimulant HUMAN OTC DRUG LABEL 2 0363-0827 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener LaxativePlus Stimulant HUMAN OTC DRUG LABEL 2 0363-0827 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0883 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0883 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
SENNA-S HUMAN OTC DRUG LABEL 2 0363-3010 CAPSULE, GELATIN COATED 8.60 mg ORAL OTC monograph not final 15 sections
SENNA-S HUMAN OTC DRUG LABEL 2 0363-3010 CAPSULE, GELATIN COATED 8.60 mg ORAL OTC monograph not final 15 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-3480 TABLET, SUGAR COATED 25 mg ORAL OTC monograph not final 16 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-3480 TABLET, SUGAR COATED 25 mg ORAL OTC monograph not final 16 sections
Chocolated Laxative HUMAN OTC DRUG LABEL 1 0363-5000 TABLET, CHEWABLE 15 mg ORAL OTC monograph not final 17 sections
Chocolated Laxative HUMAN OTC DRUG LABEL 1 0363-5000 TABLET, CHEWABLE 15 mg ORAL OTC monograph not final 17 sections
Walgreens Senna Laxative HUMAN OTC DRUG LABEL 1 0363-7120 LIQUID 25 mg ORAL OTC monograph not final 13 sections
Walgreens Senna Laxative HUMAN OTC DRUG LABEL 1 0363-7120 LIQUID 25 mg ORAL OTC monograph not final 13 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 2 0363-8550 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 2 0363-8550 TABLET 8.60 mg ORAL OTC monograph not final 14 sections