sennosides 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4307 104428-88-8

Description:

MoleculeDescription

Synonyms:

  • sennosides a&b
  • sennosides a and b
  • sennosides
Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.
  • Molecular weight: 1725.49
  • Formula: C84H76O40
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 347.91 9.56 510 82879 818823 49702912
Constipation 317.97 9.56 842 82547 184866 50336869
Pneumonia aspiration 191.97 9.56 246 83143 30758 50490977
Systemic lupus erythematosus 173.24 9.56 16 83373 140606 50381129
Temperature regulation disorder 168.13 9.56 98 83291 4129 50517606
Maternal exposure during pregnancy 153.99 9.56 37 83352 159741 50361994
Hand deformity 146.39 9.56 4 83385 100195 50421540
Drug intolerance 134.37 9.56 99 83290 219005 50302730
Treatment failure 130.42 9.56 33 83356 137604 50384131
Synovitis 126.81 9.56 25 83364 123840 50397895
Plasma cell myeloma 124.01 9.56 201 83188 31121 50490614
Joint swelling 123.80 9.56 133 83256 245153 50276582
Gastrooesophageal reflux disease 122.89 9.56 339 83050 76089 50445646
Glossodynia 118.99 9.56 23 83366 115546 50406189
Food allergy 118.42 9.56 102 83287 8035 50513700
Therapeutic product effect decreased 115.45 9.56 40 83349 136010 50385725
Completed suicide 113.26 9.56 38 83351 131851 50389884
Arthropathy 110.96 9.56 61 83328 157845 50363890
Alopecia 110.70 9.56 145 83244 244902 50276833
Coeliac disease 108.77 9.56 100 83289 8585 50513150
Pulmonary embolism 106.44 9.56 389 83000 101315 50420420
Dehydration 89.60 9.56 491 82898 151958 50369777
Deep vein thrombosis 88.49 9.56 294 83095 73010 50448725
Immunodeficiency 87.61 9.56 115 83274 14713 50507022
Pericarditis 86.85 9.56 13 83376 78676 50443059
Discomfort 83.47 9.56 37 83352 108343 50413392
Drug interaction 82.28 9.56 126 83263 199495 50322240
Off label use 81.69 9.56 454 82935 473972 50047763
Mental status changes 79.40 9.56 181 83208 36091 50485644
Wound 78.56 9.56 38 83351 105756 50415979
Contraindicated product administered 78.21 9.56 78 83311 148880 50372855
Pleural effusion 75.67 9.56 300 83089 81154 50440581
Exposure during pregnancy 75.00 9.56 54 83335 120961 50400774
Swelling 74.26 9.56 136 83253 200736 50320999
Fluid retention 72.01 9.56 215 83174 50434 50471301
Arthralgia 67.97 9.56 434 82955 438268 50083467
Bursitis 66.72 9.56 126 83263 22009 50499726
Oedema peripheral 66.52 9.56 467 82922 157494 50364241
Back pain 63.12 9.56 596 82793 219434 50302301
Pneumonia 62.70 9.56 922 82467 377479 50144256
Salpingo-oophorectomy unilateral 62.59 9.56 26 83363 515 50521220
Haemoglobin decreased 62.56 9.56 391 82998 126825 50394910
Toxicity to various agents 61.97 9.56 164 83225 212335 50309400
Product use issue 60.94 9.56 95 83294 149380 50372355
Platelet count decreased 60.87 9.56 327 83062 100399 50421336
Helicobacter infection 60.25 9.56 6 83383 49696 50472039
Abdominal discomfort 60.08 9.56 189 83200 231452 50290283
Duodenal ulcer perforation 59.46 9.56 4 83385 45607 50476128
Sinusitis fungal 59.25 9.56 33 83356 1273 50520462
Coma 58.99 9.56 217 83172 56662 50465073
Chronic sinusitis 58.68 9.56 61 83328 6084 50515651
Condition aggravated 53.92 9.56 279 83110 296779 50224956
Sputum increased 53.19 9.56 35 83354 1832 50519903
Failure to thrive 51.74 9.56 58 83331 6300 50515435
Rash erythematous 51.49 9.56 150 83239 34702 50487033
Nasal polyps 49.83 9.56 38 83351 2516 50519219
Folliculitis 49.53 9.56 4 83385 39221 50482514
Muscle injury 49.13 9.56 3 83386 37108 50484627
Upper respiratory tract infection 49.06 9.56 227 83162 65671 50456064
Intentional overdose 48.64 9.56 21 83368 62483 50459252
Embolism venous 48.02 9.56 37 83352 2488 50519247
Therapeutic product effect incomplete 46.78 9.56 49 83340 91466 50430269
Small intestinal obstruction 46.62 9.56 90 83299 15978 50505757
Hyperhidrosis 46.56 9.56 279 83110 89147 50432588
Asthma 46.05 9.56 278 83111 89059 50432676
Abdominal pain 45.71 9.56 592 82797 235636 50286099
Female genital tract fistula 45.49 9.56 42 83347 3624 50518111
Psoriatic arthropathy 43.14 9.56 12 83377 47020 50474715
Respiratory symptom 42.93 9.56 34 83355 2380 50519355
Diastolic dysfunction 42.52 9.56 48 83341 5254 50516481
Asthenia 42.50 9.56 750 82639 318292 50203443
Anaemia 42.45 9.56 617 82772 251839 50269896
Rheumatoid arthritis 42.15 9.56 181 83208 202369 50319366
Febrile neutropenia 41.81 9.56 290 83099 97377 50424358
Hiatus hernia 41.77 9.56 93 83296 18251 50503484
Blood uric acid decreased 41.61 9.56 21 83368 661 50521074
Irritable bowel syndrome 40.48 9.56 17 83372 51424 50470311
Eosinophil percentage increased 40.20 9.56 23 83366 935 50520800
Neutrophil count decreased 39.92 9.56 166 83223 45860 50475875
Musculoskeletal stiffness 39.87 9.56 96 83293 128385 50393350
Urinary tract infection 39.04 9.56 551 82838 223469 50298266
White blood cell count decreased 38.46 9.56 326 83063 116396 50405339
Diverticulum 37.83 9.56 65 83324 10549 50511186
Disease progression 37.75 9.56 279 83110 95587 50426148
Cestode infection 37.33 9.56 15 83374 272 50521463
Infection 36.93 9.56 153 83236 172801 50348934
Somnolence 36.81 9.56 404 82985 154581 50367154
Malignant neoplasm progression 36.39 9.56 214 83175 67910 50453825
Ileus 35.84 9.56 72 83317 13157 50508578
Cardiac failure congestive 34.04 9.56 247 83142 84135 50437600
Carbohydrate antigen 125 increased 34.03 9.56 30 83359 2437 50519298
Peritonitis bacterial 33.69 9.56 40 83349 4621 50517114
Iron deficiency anaemia 33.56 9.56 81 83308 16753 50504982
Injection site pain 32.85 9.56 85 83304 110939 50410796
Sleep apnoea syndrome 32.67 9.56 100 83289 23768 50497967
Drug hypersensitivity 32.59 9.56 261 83128 250749 50270986
Abortion spontaneous 32.56 9.56 14 83375 41758 50479977
Magnesium deficiency 32.29 9.56 16 83373 484 50521251
Oesophageal spasm 31.83 9.56 28 83361 2268 50519467
Drug abuse 31.77 9.56 31 83358 59815 50461920
Decreased appetite 31.00 9.56 484 82905 200439 50321296
Hepatocellular injury 29.29 9.56 4 83385 25943 50495792
Premenstrual syndrome 29.24 9.56 16 83373 596 50521139
Fungal infection 29.13 9.56 112 83277 29853 50491882
Foetal exposure during pregnancy 29.10 9.56 5 83384 27354 50494381
Product use in unapproved indication 28.94 9.56 96 83293 115723 50406012
Oesophageal pain 28.91 9.56 29 83360 2773 50518962
Blood creatinine decreased 28.48 9.56 38 83351 4938 50516797
Gastrointestinal disorder 28.18 9.56 72 83317 94384 50427351
Psoriasis 27.02 9.56 45 83344 68955 50452780
Drug reaction with eosinophilia and systemic symptoms 26.54 9.56 7 83382 28417 50493318
Lip pruritus 26.35 9.56 16 83373 727 50521008
Injection site erythema 25.68 9.56 53 83336 74883 50446852
Granulocytopenia 25.53 9.56 37 83352 5194 50516541
Injection site swelling 25.39 9.56 19 83370 41754 50479981
Injection site reaction 25.32 9.56 27 83362 50005 50471730
Haemorrhoids 25.31 9.56 79 83310 18974 50502761
Respiratory failure 25.10 9.56 245 83144 90936 50430799
Intentional product use issue 25.04 9.56 56 83333 76862 50444873
Accidental exposure to product 25.00 9.56 4 83385 23053 50498682
Knee arthroplasty 24.93 9.56 14 83375 35832 50485903
Suicide attempt 23.93 9.56 30 83359 51702 50470033
Tricuspid valve incompetence 23.92 9.56 60 83329 12710 50509025
Device expulsion 23.53 9.56 9 83380 28813 50492922
Inflammation 23.33 9.56 36 83353 56876 50464859
Intentional self-injury 22.94 9.56 5 83384 23107 50498628
Polymenorrhoea 22.72 9.56 17 83372 1094 50520641
Injection site pruritus 22.55 9.56 20 83369 40391 50481344
Vomiting 22.39 9.56 950 82439 459808 50061927
Lichen sclerosus 22.24 9.56 16 83373 969 50520766
Spinal compression fracture 22.19 9.56 58 83331 12598 50509137
Chronic obstructive pulmonary disease 21.88 9.56 157 83232 53278 50468457
Rash 21.71 9.56 552 82837 436919 50084816
Liver injury 21.53 9.56 7 83382 24799 50496936
International normalised ratio increased 21.41 9.56 133 83256 43019 50478716
Drug resistance 21.26 9.56 3 83386 18986 50502749
Dysphagia 21.19 9.56 208 83181 77310 50444425
Abdominal distension 20.61 9.56 197 83192 72706 50449029
Hypophagia 20.24 9.56 95 83294 27633 50494102
Aspiration 20.01 9.56 46 83343 9218 50512517
Pregnancy 19.93 9.56 12 83377 29565 50492170
Infusion related reaction 19.88 9.56 181 83208 169376 50352359
Blood sodium decreased 19.71 9.56 78 83311 21069 50500666
Peripheral swelling 19.57 9.56 231 83158 205705 50316030
Emphysema 19.48 9.56 45 83344 9048 50512687
Menstruation delayed 18.94 9.56 17 83372 1414 50520321
Sinusitis 18.74 9.56 185 83204 170373 50351362
Hypoxia 18.55 9.56 146 83243 50977 50470758
Cardiac murmur 18.48 9.56 49 83340 10735 50511000
Nausea 18.46 9.56 1374 82015 704024 49817711
Total lung capacity decreased 18.41 9.56 16 83373 1275 50520460
Cellulitis 18.40 9.56 188 83201 70610 50451125
Red blood cell sedimentation rate increased 18.37 9.56 13 83376 29403 50492332
Atelectasis 18.34 9.56 69 83320 18201 50503534
Therapeutic response decreased 18.31 9.56 31 83358 47200 50474535
Impaired healing 18.01 9.56 57 83332 69729 50452006
Non-small cell lung cancer 17.69 9.56 23 83366 2914 50518821
Lymphoedema 17.23 9.56 43 83346 9079 50512656
Lower gastrointestinal haemorrhage 16.94 9.56 36 83353 6843 50514892
Malignant neoplasm of thorax 16.94 9.56 4 83385 9 50521726
Blister 16.73 9.56 78 83311 85340 50436395
Gastrointestinal haemorrhage 16.41 9.56 189 83200 73132 50448603
Decubitus ulcer 16.35 9.56 43 83346 9375 50512360
General physical health deterioration 16.28 9.56 153 83236 142281 50379454
Cholestasis 16.16 9.56 11 83378 25390 50496345
Compression fracture 16.09 9.56 32 83357 5805 50515930
Breath sounds abnormal 16.08 9.56 38 83351 7754 50513981
Blood potassium decreased 15.97 9.56 110 83279 36835 50484900
Death 15.80 9.56 671 82718 324708 50197027
Adverse drug reaction 15.78 9.56 43 83346 55179 50466556
Blood cholesterol increased 15.77 9.56 43 83346 55172 50466563
Haematocrit decreased 15.63 9.56 105 83284 34871 50486864
Cholinergic syndrome 15.57 9.56 9 83380 373 50521362
Bronchopulmonary aspergillosis allergic 15.47 9.56 14 83375 1177 50520558
Live birth 15.40 9.56 4 83385 16404 50505331
Ecchymosis 15.24 9.56 44 83345 10125 50511610
Injection site rash 15.07 9.56 4 83385 16173 50505562
Fall 15.00 9.56 685 82704 334247 50187488
Hysterectomy 14.70 9.56 37 83352 7853 50513882
Hepatotoxicity 14.57 9.56 14 83375 27212 50494523
Blood urea increased 14.52 9.56 77 83312 23508 50498227
Mobility decreased 14.51 9.56 75 83314 79873 50441862
Sepsis 14.40 9.56 303 83086 132622 50389113
Body temperature fluctuation 14.37 9.56 17 83372 1956 50519779
Lung opacity 14.37 9.56 17 83372 1956 50519779
Hip fracture 14.19 9.56 82 83307 25849 50495886
Blood calcium increased 14.18 9.56 36 83353 7683 50514052
Intestinal obstruction 14.16 9.56 83 83306 26300 50495435
C-reactive protein increased 14.05 9.56 59 83330 66415 50455320
Obstructive airways disorder 14.00 9.56 57 83332 15595 50506140
Candida infection 13.94 9.56 76 83313 23447 50498288
Wrong technique in product usage process 13.86 9.56 46 83343 55464 50466271
Acute respiratory failure 13.83 9.56 88 83301 28694 50493041
Hip arthroplasty 13.71 9.56 18 83371 30411 50491324
Loss of personal independence in daily activities 13.70 9.56 64 83325 69986 50451749
Intentional product misuse 13.65 9.56 36 83353 46698 50475037
Blood alkaline phosphatase increased 13.52 9.56 107 83282 37419 50484316
Enterocolitis 13.52 9.56 32 83357 6535 50515200
Malnutrition 13.40 9.56 50 83339 13139 50508596
Ascites 13.33 9.56 103 83286 35758 50485977
Product dose omission issue 13.25 9.56 218 83171 183620 50338115
Arthritis 13.25 9.56 86 83303 86635 50435100
Pruritus 13.19 9.56 361 83028 283207 50238528
Gingival pain 13.17 9.56 30 83359 5976 50515759
Full blood count decreased 13.11 9.56 72 83317 22274 50499461
Dyspnoea 13.02 9.56 1059 82330 546549 49975186
Premature baby 12.98 9.56 7 83382 18330 50503405
Small cell lung cancer extensive stage 12.94 9.56 3 83386 6 50521729
Hypervolaemia 12.90 9.56 79 83310 25420 50496315
Hospice care 12.84 9.56 29 83360 5743 50515992
Cholecystitis chronic 12.76 9.56 40 83349 9629 50512106
Flank pain 12.73 9.56 49 83340 13066 50508669
Atrial fibrillation 12.72 9.56 237 83152 101508 50420227
Anaphylactic reaction 12.69 9.56 46 83343 54009 50467726
Bronchial artery embolisation 12.63 9.56 3 83386 7 50521728
Injection site bruising 12.60 9.56 26 83363 36742 50484993
Unresponsive to stimuli 12.56 9.56 90 83299 30519 50491216
Limb crushing injury 12.40 9.56 6 83383 172 50521563
Rectal haemorrhage 12.32 9.56 107 83282 38451 50483284
Lactic acidosis 11.93 9.56 23 83366 33332 50488403
Injection site warmth 11.88 9.56 4 83385 13862 50507873
Serotonin syndrome 11.78 9.56 14 83375 24699 50497036
Parkinson's disease 11.66 9.56 12 83377 1183 50520552
Therapy non-responder 11.59 9.56 44 83345 50978 50470757
Onychoclasis 11.44 9.56 26 83363 5170 50516565
Arteriovenous graft site infection 11.42 9.56 3 83386 12 50521723
Polyneuropathy 11.30 9.56 3 83386 12128 50509607
Chest pain 11.26 9.56 376 83013 176506 50345229
Neuralgia 11.23 9.56 68 83321 21795 50499940
Hallucination 11.23 9.56 122 83267 46535 50475200
Type 2 diabetes mellitus 11.20 9.56 25 83364 34350 50487385
Postmenopausal haemorrhage 11.15 9.56 15 83374 1965 50519770
Gastrointestinal injury 11.08 9.56 8 83381 487 50521248
Blood loss anaemia 11.04 9.56 34 83355 8105 50513630
Wound infection bacterial 10.92 9.56 8 83381 498 50521237
Acquired epidermolysis bullosa 10.90 9.56 4 83385 56 50521679
Urinary retention postoperative 10.90 9.56 4 83385 56 50521679
White blood cell count increased 10.89 9.56 112 83277 42128 50479607
Retching 10.84 9.56 46 83343 12816 50508919
Blood creatinine increased 10.80 9.56 181 83208 75979 50445756
Gastric ulcer 10.78 9.56 66 83323 21239 50500496
Cystocele 10.74 9.56 11 83378 1078 50520657
Heart rate increased 10.74 9.56 183 83206 77067 50444668
Radiation associated pain 10.71 9.56 4 83385 59 50521676
Embolic stroke 10.70 9.56 20 83369 3464 50518271
Multiple sclerosis 10.69 9.56 64 83325 20429 50501306
Bone erosion 10.68 9.56 3 83386 11684 50510051
Ill-defined disorder 10.65 9.56 50 83339 54604 50467131
Rubber sensitivity 10.64 9.56 14 83375 1795 50519940
Hypoalbuminaemia 10.54 9.56 38 83351 9822 50511913
Insulin C-peptide increased 10.47 9.56 4 83385 63 50521672
Basal cell carcinoma 10.33 9.56 14 83375 23342 50498393
Eosinophil count increased 10.27 9.56 35 83354 8795 50512940
Hypersensitivity 10.23 9.56 273 83116 214888 50306847
Non-Hodgkin's lymphoma 10.19 9.56 12 83377 1374 50520361
Intracranial hypotension 10.18 9.56 6 83383 258 50521477
Progressive multiple sclerosis 10.05 9.56 9 83380 746 50520989
Lymphocyte count decreased 10.03 9.56 76 83313 26231 50495504
Pharyngeal mass 9.97 9.56 6 83383 268 50521467
Proctalgia 9.89 9.56 24 83365 4979 50516756
Silent thyroiditis 9.88 9.56 4 83385 74 50521661
Injection site extravasation 9.87 9.56 31 83358 7470 50514265
Product prescribing error 9.86 9.56 12 83377 20949 50500786
Premature delivery 9.67 9.56 15 83374 23648 50498087

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 182.09 10.16 275 58366 362895 29152991
Constipation 145.49 10.16 527 58114 113633 29402253
Completed suicide 108.96 10.16 23 58618 90223 29425663
Off label use 108.64 10.16 276 58365 300524 29215362
Drug abuse 91.17 10.16 23 58618 79860 29436026
Plasma cell myeloma 82.90 10.16 209 58432 36906 29478980
Dehydration 81.44 10.16 445 58196 114303 29401583
Drug interaction 79.21 10.16 171 58470 197214 29318672
Pneumonia 64.20 10.16 939 57702 319233 29196653
Toxicity to various agents 63.55 10.16 158 58483 173503 29342383
Mental status changes 54.73 10.16 173 58468 34754 29481132
Product use in unapproved indication 51.23 10.16 58 58583 86817 29429069
Disease progression 47.28 10.16 301 58340 81615 29434271
Intentional overdose 42.22 10.16 12 58629 38516 29477370
Urinary tract infection 38.77 10.16 261 58380 72093 29443793
Febrile neutropenia 37.81 10.16 364 58277 111876 29404010
Malignant neoplasm progression 36.96 10.16 262 58379 73597 29442289
White blood cell count increased 36.23 10.16 159 58482 37357 29478529
Fall 35.48 10.16 520 58121 176658 29339228
Platelet count decreased 35.02 10.16 339 58302 104333 29411553
Foetal exposure during pregnancy 34.51 10.16 12 58629 33855 29482031
Decreased appetite 34.15 10.16 439 58202 144903 29370983
Haemoglobin decreased 33.84 10.16 346 58295 108029 29407857
Pleural effusion 33.63 10.16 251 58390 71657 29444229
Dysphagia 32.39 10.16 203 58438 54723 29461163
Condition aggravated 31.00 10.16 167 58474 146128 29369758
Haematocrit decreased 30.33 10.16 126 58515 28896 29486990
Failure to thrive 29.58 10.16 54 58587 7630 29508256
Muscular weakness 28.67 10.16 216 58425 61836 29454050
Confusional state 28.25 10.16 382 58259 127495 29388391
Deep vein thrombosis 27.77 10.16 202 58439 57197 29458689
Overdose 26.58 10.16 76 58565 79743 29436143
Hepatocellular injury 26.48 10.16 5 58636 21238 29494648
Cholestasis 26.28 10.16 7 58634 23455 29492431
Treatment failure 26.03 10.16 21 58620 36918 29478968
Metastatic renal cell carcinoma 24.19 10.16 24 58617 1878 29514008
Neutrophil count decreased 23.83 10.16 158 58483 43409 29472477
Pneumonia aspiration 23.70 10.16 139 58502 36598 29479288
Therapeutic product effect incomplete 23.42 10.16 26 58615 39279 29476607
Contraindicated product administered 23.41 10.16 4 58637 18262 29497624
Product dose omission issue 23.29 10.16 105 58536 96278 29419608
Hallucination 23.17 10.16 160 58481 44552 29471334
Ileus 22.24 10.16 71 58570 14331 29501555
Drug reaction with eosinophilia and systemic symptoms 22.23 10.16 14 58627 27978 29487908
Drug hypersensitivity 22.14 10.16 66 58575 68340 29447546
Red blood cell count decreased 22.10 10.16 105 58536 25497 29490389
Urinary retention 22.09 10.16 123 58518 31775 29484111
White blood cell count decreased 21.79 10.16 257 58384 83105 29432781
Soft tissue mass 20.96 10.16 14 58627 622 29515264
Decubitus ulcer 20.48 10.16 45 58596 7266 29508620
Multimorbidity 20.20 10.16 13 58628 542 29515344
Pulmonary embolism 20.03 10.16 236 58405 76298 29439588
Burkholderia test positive 19.41 10.16 16 58625 983 29514903
Granulocytopenia 19.23 10.16 39 58602 5955 29509931
Back pain 19.18 10.16 297 58344 101987 29413899
Asthenia 19.06 10.16 560 58081 214690 29301196
Subacute endocarditis 18.84 10.16 6 58635 43 29515843
Oesophageal perforation 18.80 10.16 14 58627 741 29515145
Suicide attempt 18.79 10.16 24 58617 34086 29481800
Hypoxia 18.65 10.16 159 58482 47220 29468666
Rheumatoid arthritis 18.36 10.16 22 58619 32130 29483756
Neurogenic bladder 18.28 10.16 19 58622 1571 29514315
Pneumonitis 18.01 10.16 106 58535 27938 29487948
Premature baby 17.82 10.16 6 58635 17274 29498612
Pathological fracture 17.32 10.16 29 58612 3826 29512060
Atelectasis 17.01 10.16 68 58573 15324 29500562
Neutrophil count increased 17.00 10.16 66 58575 14676 29501210
Wrong technique in product usage process 16.41 10.16 23 58618 31405 29484481
Eosinophil percentage increased 16.23 10.16 11 58630 501 29515385
Injection site pain 15.72 10.16 25 58616 32421 29483465
Hypophagia 15.47 10.16 82 58559 20790 29495096
Dyspnoea paroxysmal nocturnal 14.86 10.16 16 58625 1378 29514508
Biliary obstruction 14.84 10.16 21 58620 2393 29513493
Streptococcus test positive 14.78 10.16 13 58628 873 29515013
Superinfection 14.73 10.16 19 58622 1982 29513904
Oral pustule 14.72 10.16 8 58633 243 29515643
Sepsis 14.23 10.16 377 58264 142305 29373581
Stupor 14.18 10.16 22 58619 2722 29513164
Eosinophilia 13.94 10.16 14 58627 22147 29493739
Multiple organ dysfunction syndrome 13.93 10.16 71 58570 63045 29452841
Cancer pain 13.82 10.16 20 58621 2327 29513559
Blood sodium decreased 13.80 10.16 62 58579 14705 29501181
Calculus bladder 13.34 10.16 12 58629 830 29515056
Angioedema 13.30 10.16 27 58614 31888 29483998
Toxic epidermal necrolysis 13.19 10.16 10 58631 18143 29497743
Metabolic acidosis 13.17 10.16 35 58606 37627 29478259
Lactic acidosis 13.11 10.16 25 58616 30222 29485664
Intentional product use issue 13.04 10.16 42 58599 42456 29473430
Disturbance in attention 12.95 10.16 14 58627 21410 29494476
Hospice care 12.86 10.16 30 58611 5038 29510848
Cardiac failure congestive 12.72 10.16 218 58423 76363 29439523
Fatigue 12.72 10.16 758 57883 316063 29199823
Muscle spasticity 12.50 10.16 29 58612 4854 29511032
Lumbar spinal stenosis 12.34 10.16 19 58622 2336 29513550
Intentional product misuse 12.28 10.16 32 58609 34629 29481257
Paratracheal lymphadenopathy 12.01 10.16 5 58636 82 29515804
Full blood count decreased 11.97 10.16 63 58578 15929 29499957
Delirium 11.90 10.16 125 58516 39272 29476614
Product use issue 11.85 10.16 57 58584 51387 29464499
Vomiting 11.80 10.16 524 58117 211736 29304150
Urticaria 11.77 10.16 62 58579 54598 29461288
Intentional self-injury 11.72 10.16 5 58636 12456 29503430
Asthma 11.43 10.16 32 58609 33817 29482069
Peritonitis bacterial 11.39 10.16 31 58610 5725 29510161
Radiation skin injury 11.39 10.16 10 58631 670 29515216
Accidental overdose 11.19 10.16 11 58630 17582 29498304
Water intoxication 11.12 10.16 8 58633 401 29515485
Withdrawal syndrome 11.02 10.16 4 58637 10988 29504898
Abdominal distension 10.89 10.16 139 58502 45772 29470114
Synovitis 10.85 10.16 4 58637 10886 29505000
Band neutrophil percentage increased 10.84 10.16 5 58636 106 29515780
Faecaloma 10.80 10.16 25 58616 4177 29511709
Monocyte percentage increased 10.66 10.16 11 58630 902 29514984
Oesophageal carcinoma 10.56 10.16 26 58615 4521 29511365
Dextrocardia 10.43 10.16 5 58636 116 29515770
Blood creatine phosphokinase decreased 10.42 10.16 8 58633 443 29515443
Spinal compression fracture 10.29 10.16 31 58610 6063 29509823
Unresponsive to stimuli 10.24 10.16 85 58556 25041 29490845
Haemophagocytic lymphohistiocytosis 10.23 10.16 4 58637 10500 29505386
Gastrointestinal stromal tumour 10.21 10.16 10 58631 770 29515116

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 371.82 9.76 567 112931 839680 63545554
Constipation 308.92 9.76 996 112502 228341 64156893
Completed suicide 224.23 9.76 59 113439 224355 64160879
Plasma cell myeloma 167.29 9.76 295 113203 45780 64339454
Off label use 163.15 9.76 570 112928 632236 63752998
Temperature regulation disorder 159.92 9.76 97 113401 4114 64381120
Toxicity to various agents 154.53 9.76 251 113247 363262 64021972
Pneumonia aspiration 153.48 9.76 329 113169 58942 64326292
Drug interaction 135.93 9.76 270 113228 361813 64023421
Dehydration 126.47 9.76 731 112767 216032 64169202
Food allergy 117.77 9.76 103 113395 7748 64377486
Synovitis 111.16 9.76 20 113478 99070 64286164
Drug abuse 110.86 9.76 47 113451 132327 64252907
Coeliac disease 110.70 9.76 97 113401 7315 64377919
Mental status changes 106.22 9.76 291 113207 60871 64324363
Pulmonary embolism 106.06 9.76 524 112974 145832 64239402
Pneumonia 103.55 9.76 1467 112031 558109 63827125
Drug intolerance 98.81 9.76 111 113387 187881 64197353
Hand deformity 96.69 9.76 3 113495 62768 64322466
Systemic lupus erythematosus 95.46 9.76 12 113486 77600 64307634
Pemphigus 93.15 9.76 3 113495 60698 64324536
Joint swelling 93.02 9.76 147 113351 215235 64169999
Deep vein thrombosis 91.24 9.76 397 113101 104785 64280449
Treatment failure 90.81 9.76 46 113452 116770 64268464
Gastrooesophageal reflux disease 90.65 9.76 337 113161 82806 64302428
Febrile neutropenia 90.05 9.76 602 112896 187055 64198179
Platelet count decreased 89.06 9.76 552 112946 167159 64218075
Maternal exposure during pregnancy 80.34 9.76 34 113464 95850 64289384
Pleural effusion 77.80 9.76 433 113065 126126 64259108
Immunodeficiency 77.17 9.76 117 113381 16007 64369227
Intentional overdose 76.81 9.76 31 113467 89913 64295321
Malignant neoplasm progression 76.74 9.76 397 113101 112474 64272760
Therapeutic product effect decreased 74.96 9.76 56 113442 115295 64269939
Haemoglobin decreased 73.10 9.76 590 112908 194473 64190761
Arthropathy 70.85 9.76 65 113433 120902 64264332
Condition aggravated 70.80 9.76 376 113122 372050 64013184
Back pain 69.91 9.76 710 112788 249461 64135773
Fluid retention 67.82 9.76 245 113253 59361 64325873
Alopecia 66.96 9.76 118 113380 165572 64219662
Failure to thrive 65.37 9.76 86 113412 10318 64374916
Neutrophil count decreased 63.62 9.76 287 113211 76909 64308325
Product use in unapproved indication 61.70 9.76 137 113361 176481 64208753
Ileus 60.02 9.76 128 113370 22838 64362396
Disease progression 59.99 9.76 441 113057 141239 64243995
Bursitis 59.94 9.76 123 113375 21362 64363872
Arthralgia 59.17 9.76 496 113002 441764 63943470
Eosinophil percentage increased 57.17 9.76 34 113464 1390 64383844
Exposure during pregnancy 56.83 9.76 33 113465 77642 64307592
Salpingo-oophorectomy unilateral 56.41 9.76 24 113474 472 64384762
Discomfort 55.52 9.76 37 113461 80841 64304393
Hepatocellular injury 53.24 9.76 8 113490 45227 64340007
Urinary tract infection 52.61 9.76 631 112867 230965 64154269
Granulocytopenia 50.30 9.76 76 113422 10364 64374870
White blood cell count decreased 49.97 9.76 460 113038 157377 64227857
Decreased appetite 49.63 9.76 732 112766 280557 64104677
Pericarditis 49.50 9.76 24 113474 62492 64322742
Oedema peripheral 47.31 9.76 572 112926 209745 64175489
Injection site pain 46.22 9.76 78 113420 111330 64273904
Chronic sinusitis 45.85 9.76 56 113442 6236 64378998
Glossodynia 45.22 9.76 29 113469 64667 64320567
Upper respiratory tract infection 44.68 9.76 249 113249 72536 64312698
Helicobacter infection 44.66 9.76 7 113491 38355 64346879
Drug resistance 44.21 9.76 5 113493 35097 64350137
Female genital tract fistula 44.21 9.76 37 113461 2621 64382613
Duodenal ulcer perforation 43.44 9.76 5 113493 34620 64350614
Therapeutic response decreased 42.92 9.76 19 113479 52169 64333065
White blood cell count increased 42.65 9.76 229 113269 65785 64319449
Drug reaction with eosinophilia and systemic symptoms 42.64 9.76 21 113477 54196 64331038
Therapeutic product effect incomplete 42.42 9.76 73 113425 103409 64281825
Peritonitis bacterial 42.40 9.76 65 113433 8978 64376256
Sinusitis fungal 42.06 9.76 30 113468 1676 64383558
Dysphagia 41.57 9.76 326 113172 106486 64278748
Cholestasis 40.76 9.76 14 113484 44858 64340376
Contraindicated product administered 40.71 9.76 80 113418 107749 64277485
Hiatus hernia 39.78 9.76 100 113398 19857 64365377
Haematocrit decreased 38.34 9.76 194 113304 54461 64330773
Suicide attempt 38.29 9.76 41 113457 70966 64314268
Product use issue 37.98 9.76 138 113360 151577 64233657
Oesophageal spasm 37.62 9.76 33 113465 2492 64382742
Intentional product use issue 37.53 9.76 69 113429 95295 64289939
Hyperhidrosis 37.00 9.76 359 113139 124561 64260673
Cestode infection 36.84 9.76 15 113483 263 64384971
Psoriatic arthropathy 36.81 9.76 15 113483 43266 64341968
Rash erythematous 35.80 9.76 175 113323 48458 64336776
Blood uric acid decreased 35.75 9.76 23 113475 1083 64384151
Carbohydrate antigen 125 increased 34.49 9.76 28 113470 1900 64383334
Respiratory symptom 34.11 9.76 34 113464 3019 64382215
Drug hypersensitivity 33.90 9.76 262 113236 237553 64147681
Hypoxia 33.72 9.76 268 113230 87881 64297353
Inflammation 32.72 9.76 40 113458 65260 64319974
Sputum increased 32.60 9.76 36 113462 3599 64381635
Wound 32.22 9.76 53 113445 76424 64308810
Folliculitis 31.78 9.76 7 113491 30070 64355164
Irritable bowel syndrome 31.70 9.76 13 113485 37356 64347878
Anaemia 31.56 9.76 881 112617 377799 64007435
Small intestinal obstruction 31.27 9.76 102 113396 23471 64361763
Injection site reaction 31.16 9.76 22 113476 46642 64338592
Injection site swelling 31.06 9.76 17 113481 41336 64343898
Nasal polyps 30.93 9.76 35 113463 3594 64381640
Blood sodium decreased 30.87 9.76 118 113380 29364 64355870
Premenstrual syndrome 30.58 9.76 16 113482 508 64384726
Intentional self-injury 30.20 9.76 7 113491 29037 64356197
Embolism venous 30.19 9.76 34 113464 3473 64381761
Red blood cell count decreased 30.00 9.76 166 113332 48220 64337014
Hallucination 29.89 9.76 225 113273 72563 64312671
Rheumatoid arthritis 29.44 9.76 169 113329 164125 64221109
Gastrointestinal disorder 29.37 9.76 72 113426 89637 64295597
Asthenia 29.03 9.76 971 112527 427073 63958161
Injection site erythema 28.96 9.76 50 113448 70750 64314484
Hypophagia 28.82 9.76 142 113356 39445 64345789
Sepsis 28.43 9.76 566 112932 229775 64155459
Muscle injury 28.24 9.76 6 113492 26431 64358803
Intentional product misuse 27.83 9.76 53 113445 72242 64312992
Asthma 27.38 9.76 272 113226 94953 64290281
Spinal compression fracture 27.35 9.76 72 113426 14703 64370531
Abdominal distension 27.02 9.76 273 113225 95721 64289513
Magnesium deficiency 26.75 9.76 15 113483 548 64384686
Muscular weakness 26.74 9.76 342 113156 126996 64258238
Fall 25.63 9.76 935 112563 415891 63969343
Oesophageal pain 25.35 9.76 30 113468 3233 64382001
Polymenorrhoea 24.76 9.76 17 113481 893 64384341
Musculoskeletal stiffness 24.70 9.76 122 113376 123084 64262150
Decubitus ulcer 24.56 9.76 65 113433 13314 64371920
Product dose omission issue 24.38 9.76 222 113276 194525 64190709
Accidental exposure to product 24.34 9.76 8 113490 26356 64358878
Blood creatinine decreased 24.12 9.76 44 113454 7006 64378228
Diverticulum 24.11 9.76 64 113434 13134 64372100
Iron deficiency anaemia 24.07 9.76 89 113409 21800 64363434
Respiratory failure 24.05 9.76 408 113090 160775 64224459
Abdominal pain 23.88 9.76 719 112779 311656 64073578
Cardiac failure congestive 23.85 9.76 342 113156 130238 64254996
Pneumonitis 23.76 9.76 161 113337 50204 64335030
Lactic acidosis 23.66 9.76 45 113453 61365 64323869
Lip pruritus 23.63 9.76 15 113483 690 64384544
Chronic obstructive pulmonary disease 23.45 9.76 209 113289 70839 64314395
Wrong technique in product usage process 23.00 9.76 50 113448 64924 64320310
Neurogenic bladder 22.87 9.76 30 113468 3589 64381645
International normalised ratio increased 22.69 9.76 226 113272 78941 64306293
Lichen sclerosus 22.64 9.76 16 113482 881 64384353
Injection site pruritus 22.52 9.76 20 113478 37806 64347428
Death 22.41 9.76 1051 112447 481654 63903580
Overdose 22.16 9.76 177 113321 159389 64225845
Cellulitis 22.03 9.76 257 113241 93400 64291834
Metastatic renal cell carcinoma 21.89 9.76 23 113475 2173 64383061
Abdominal discomfort 21.89 9.76 210 113288 182112 64203122
Somnolence 21.74 9.76 490 113008 203155 64182079
Urinary retention 21.29 9.76 154 113344 49047 64336187
Menstruation delayed 21.09 9.76 17 113481 1142 64384092
Metabolic acidosis 20.91 9.76 60 113438 70898 64314336
Fungal infection 20.89 9.76 117 113381 34134 64351100
Neuralgia 20.56 9.76 96 113402 26088 64359146
Oesophageal perforation 20.51 9.76 16 113482 1025 64384209
Diastolic dysfunction 20.41 9.76 47 113451 8828 64376406
Haemorrhoids 20.34 9.76 90 113408 23911 64361323
Swelling 20.32 9.76 182 113316 160036 64225198
Soft tissue mass 20.18 9.76 15 113483 894 64384340
Red blood cell sedimentation rate increased 19.23 9.76 16 113482 31219 64354015
Injection site bruising 18.52 9.76 22 113476 36351 64348883
Vomiting 18.43 9.76 1164 112334 549953 63835281
Hospice care 18.22 9.76 41 113457 7584 64377650
Infection 18.16 9.76 223 113275 184657 64200577
Pregnancy 18.12 9.76 7 113491 20858 64364376
Psoriasis 18.08 9.76 65 113433 71638 64313596
Abortion spontaneous 17.94 9.76 11 113487 25132 64360102
Atelectasis 17.88 9.76 95 113403 27171 64358063
Emphysema 17.88 9.76 60 113438 14009 64371225
Cancer pain 17.75 9.76 29 113469 4228 64381006
Malignant neoplasm of thorax 17.72 9.76 4 113494 6 64385228
Serotonin syndrome 17.71 9.76 26 113472 39256 64345978
Angioedema 17.69 9.76 53 113445 61768 64323466
Knee arthroplasty 17.67 9.76 13 113485 26986 64358248
Hepatotoxicity 17.48 9.76 27 113471 39935 64345299
Neutrophil count increased 17.40 9.76 89 113409 25085 64360149
Gastrointestinal haemorrhage 17.28 9.76 328 113170 131984 64253250
Radiation pneumonitis 17.14 9.76 25 113473 3303 64381931
Ecchymosis 17.11 9.76 59 113439 13963 64371271
General physical health deterioration 17.03 9.76 255 113243 204170 64181064
Unresponsive to stimuli 17.02 9.76 149 113349 50244 64334990
Sleep apnoea syndrome 16.95 9.76 100 113398 29732 64355502
Nausea 16.89 9.76 1603 111895 784197 63601037
Multimorbidity 16.65 9.76 14 113484 998 64384236
Impaired healing 16.48 9.76 53 113445 60420 64324814
Lymphocyte count decreased 16.25 9.76 125 113373 40574 64344660
Postmenopausal haemorrhage 16.07 9.76 16 113482 1419 64383815
Eosinophil count increased 16.04 9.76 58 113440 14054 64371180
Acute respiratory failure 16.02 9.76 146 113352 49788 64335446
Retching 15.92 9.76 61 113437 15195 64370039
Interstitial lung disease 15.53 9.76 250 113248 97482 64287752
Device expulsion 15.43 9.76 9 113489 21127 64364107
Acute generalised exanthematous pustulosis 15.41 9.76 3 113495 14055 64371179
Multiple organ dysfunction syndrome 15.25 9.76 110 113388 101303 64283931
Polyneuropathy 15.20 9.76 8 113490 19886 64365348
Arthritis 15.12 9.76 86 113412 83728 64301506
Lung opacity 15.00 9.76 23 113475 3176 64382058
Blood cholesterol increased 15.00 9.76 42 113456 50024 64335210
Mobility decreased 14.99 9.76 89 113409 85751 64299483
Anaphylactic shock 14.75 9.76 19 113479 30309 64354925
Therapy non-responder 14.54 9.76 63 113435 65836 64319398
Hip fracture 14.23 9.76 89 113409 27010 64358224
Poriomania 14.19 9.76 7 113491 196 64385038
Enterocolitis 14.18 9.76 50 113448 11968 64373266
Hypokalaemia 14.18 9.76 297 113201 121606 64263628
Labelled drug-drug interaction medication error 13.95 9.76 11 113487 22051 64363183
Stupor 13.92 9.76 32 113466 6003 64379231
Posterior reversible encephalopathy syndrome 13.82 9.76 12 113486 22934 64362300
Fatigue 13.72 9.76 1511 111987 747219 63638015
Myelosuppression 13.71 9.76 13 113485 23817 64361417
Total lung capacity decreased 13.65 9.76 16 113482 1706 64383528
Water intoxication 13.65 9.76 11 113487 739 64384495
Blood creatine phosphokinase decreased 13.56 9.76 11 113487 746 64384488
Haemorrhage intracranial 13.53 9.76 80 113418 23804 64361430
Malnutrition 13.49 9.76 68 113430 19057 64366177
Product prescribing error 13.45 9.76 26 113472 35243 64349991
Upper respiratory tract inflammation 13.44 9.76 24 113474 3758 64381476
Rubber sensitivity 13.37 9.76 14 113484 1318 64383916
Hypervolaemia 13.34 9.76 114 113384 38171 64347063
Basal cell carcinoma 13.33 9.76 21 113477 30817 64354417
Aspiration 13.32 9.76 62 113436 16823 64368411
Dyspnoea paroxysmal nocturnal 13.27 9.76 17 113481 1987 64383247
Perirectal abscess 12.99 9.76 16 113482 1797 64383437
Hysterectomy 12.89 9.76 28 113470 5057 64380177
Spinal cord compression 12.89 9.76 30 113468 5673 64379561
Airway burns 12.75 9.76 3 113495 6 64385228
Colitis ulcerative 12.75 9.76 13 113485 23015 64362219
Drug ineffective for unapproved indication 12.72 9.76 22 113476 31111 64354123
Disturbance in attention 12.64 9.76 34 113464 41040 64344194
Injection site warmth 12.58 9.76 4 113494 13458 64371776
Calculus bladder 12.56 9.76 13 113485 1207 64384027
Poisoning 12.51 9.76 12 113486 21867 64363367
Pruritus 12.50 9.76 437 113061 311963 64073271
Lethargy 12.41 9.76 188 113310 72406 64312828
Cystitis 12.31 9.76 122 113376 42553 64342681
Adverse drug reaction 12.28 9.76 40 113458 45424 64339810
Blood calcium increased 12.28 9.76 38 113460 8504 64376730
Urticaria 12.18 9.76 184 113314 147133 64238101
Blood urea increased 12.15 9.76 125 113373 44028 64341206
Oral pustule 12.12 9.76 7 113491 271 64384963
Cytomegalovirus infection 12.06 9.76 30 113468 37169 64348065
Dementia 12.05 9.76 70 113428 20696 64364538
Toxic epidermal necrolysis 12.03 9.76 30 113468 37136 64348098
Otorrhoea 12.02 9.76 14 113484 1483 64383751
Ascites 11.96 9.76 164 113334 61837 64323397
Blood potassium decreased 11.90 9.76 116 113382 40283 64344951
Blood thyroid stimulating hormone increased 11.90 9.76 35 113463 7619 64377615
Cardiac murmur 11.87 9.76 46 113452 11517 64373717
Myalgia 11.82 9.76 202 113296 158415 64226819
Monocyte percentage increased 11.75 9.76 16 113482 1984 64383250
Bone marrow failure 11.74 9.76 44 113454 47908 64337326
Pyrexia 11.72 9.76 1138 112360 557506 63827728
Embolic stroke 11.71 9.76 32 113466 6679 64378555
Coma 11.71 9.76 218 113280 87397 64297837
Compression fracture 11.65 9.76 29 113469 5723 64379511
Sinusitis 11.48 9.76 184 113314 145744 64239490
Bronchopulmonary aspergillosis 11.47 9.76 10 113488 19075 64366159
Delirium 11.37 9.76 178 113320 69016 64316218
Non-small cell lung cancer 11.36 9.76 26 113472 4864 64380370
Small cell lung cancer extensive stage 11.23 9.76 3 113495 12 64385222
Proctalgia 11.21 9.76 34 113464 7525 64377709
Hyponatraemia 11.19 9.76 341 113157 147998 64237236
Bronchopulmonary aspergillosis allergic 11.12 9.76 14 113484 1608 64383626
Lumbar spinal stenosis 11.11 9.76 25 113473 4625 64380609
Injection site rash 11.07 9.76 7 113491 15735 64369499
Tricuspid valve incompetence 10.99 9.76 59 113439 16944 64368290
Joint effusion 10.93 9.76 5 113493 13468 64371766
Accidental overdose 10.93 9.76 27 113471 33530 64351704
Hiccups 10.89 9.76 36 113462 8340 64376894
Lower gastrointestinal haemorrhage 10.86 9.76 51 113447 13888 64371346
Oesophageal carcinoma 10.77 9.76 25 113473 4718 64380516
Malignant neoplasm of renal pelvis 10.76 9.76 5 113493 122 64385112
Gastrointestinal injury 10.75 9.76 10 113488 815 64384419
Dysuria 10.60 9.76 117 113381 41940 64343294
Multiple sclerosis 10.44 9.76 63 113435 18878 64366356
Cholecystitis chronic 10.41 9.76 38 113460 9249 64375985
Arteriovenous graft site infection 10.37 9.76 3 113495 17 64385217
Troponin increased 10.34 9.76 54 113444 15345 64369889
Blood creatinine increased 10.20 9.76 312 113186 135470 64249764
Urinary retention postoperative 10.20 9.76 5 113493 138 64385096
Subacute endocarditis 10.20 9.76 5 113493 138 64385096
Platelet count increased 10.19 9.76 62 113436 18634 64366600
Bronchial artery embolisation 10.09 9.76 3 113495 19 64385215
Grip strength decreased 10.07 9.76 4 113494 11720 64373514
Hepatic function abnormal 10.02 9.76 164 113334 64149 64321085
Phlebosclerosis 9.94 9.76 5 113493 146 64385088
C-reactive protein increased 9.88 9.76 113 113385 94796 64290438
Paratracheal lymphadenopathy 9.88 9.76 5 113493 148 64385086
Nasopharyngitis 9.86 9.76 266 113232 195807 64189427
Lung consolidation 9.78 9.76 33 113465 7725 64377509
Umbilical hernia 9.77 9.76 23 113475 4382 64380852

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Irritable bowel syndrome off-label use 10743008 DOID:9778
Incomplete passage of stool off-label use 249515001
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Intestinal obstruction contraindication 81060008 DOID:8437
Gastrointestinal obstruction contraindication 126765001
Intestinal Impaction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021246 VUID
N0000179238 NUI
62211-03-4 SECONDARY_CAS_RN
4019930 VANDF
4021246 VANDF
C3489575 UMLSCUI
CHEMBL2108559 ChEMBL_ID
DB11365 DRUGBANK_ID
3FYP5M0IJX UNII
5199 PUBCHEM_CID
36387 RXNORM
5149 MMSL
5452 MMSL
5455 MMSL
84266 MMSL
d01013 MMSL
001169 NDDF
001170 NDDF
003868 NDDF
30125007 SNOMEDCT_US
387162007 SNOMEDCT_US
412302003 SNOMEDCT_US
420709001 SNOMEDCT_US
D000081226 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-0003 PILL 15 mg ORAL OTC monograph not final 16 sections
EX-LAXREGULAR STRENGTH CHOCOLATED STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8140 TABLET, CHEWABLE 15 mg ORAL OTC monograph not final 15 sections
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8141 TABLET 15 mg ORAL OTC monograph not final 16 sections
EX-LAXMAXIMUM STRENGTH STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0067-8142 PILL 25 mg ORAL OTC monograph not final 16 sections
Perdiem HUMAN OTC DRUG LABEL 1 0067-8143 TABLET 15 mg ORAL OTC monograph not final 15 sections
Senna Syrup HUMAN OTC DRUG LABEL 1 0121-4967 LIQUID 8.80 mg ORAL OTC monograph not final 11 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0138 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
LaxativeRegular Strength HUMAN OTC DRUG LABEL 1 0363-0347 TABLET, COATED 15 mg ORAL OTC monograph not final 16 sections
Senna laxative HUMAN OTC DRUG LABEL 1 0363-0486 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0785 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener LaxativePlus Stimulant HUMAN OTC DRUG LABEL 2 0363-0827 TABLET 8.60 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0883 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
SENNA-S HUMAN OTC DRUG LABEL 2 0363-3010 CAPSULE, GELATIN COATED 8.60 mg ORAL OTC monograph not final 15 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-3480 TABLET, SUGAR COATED 25 mg ORAL OTC monograph not final 16 sections
Chocolated Laxative HUMAN OTC DRUG LABEL 1 0363-5000 TABLET, CHEWABLE 15 mg ORAL OTC monograph not final 14 sections
Walgreens Senna Laxative HUMAN OTC DRUG LABEL 1 0363-7120 LIQUID 25 mg ORAL OTC monograph not final 13 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 2 0363-8550 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Senna HUMAN OTC DRUG LABEL 1 0363-8750 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-8760 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 2 0363-8780 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Senna HUMAN OTC DRUG LABEL 1 0363-8820 TABLET 8.60 mg ORAL OTC monograph not final 14 sections
Sennosides HUMAN OTC DRUG LABEL 1 0363-9990 CAPSULE, LIQUID FILLED 17.20 mg ORAL OTC monograph not final 13 sections
Sennosides, Docusate Sodium HUMAN OTC DRUG LABEL 2 0536-1167 TABLET, FILM COATED 8.60 mg ORAL OTC monograph not final 16 sections
Sennosides HUMAN OTC DRUG LABEL 1 0536-1168 TABLET, FILM COATED 8.60 mg ORAL OTC monograph not final 16 sections
Sennosides,Docusate sodium HUMAN OTC DRUG LABEL 2 0536-1169 TABLET, FILM COATED 8.60 mg ORAL OTC monograph not final 16 sections
Senexon-S HUMAN OTC DRUG LABEL 2 0536-1247 TABLET, FILM COATED 8.60 mg ORAL OTC monograph not final 14 sections
Stimulant Laxative Plus Stool Softener HUMAN OTC DRUG LABEL 2 0536-1248 TABLET, FILM COATED 8.60 mg ORAL OTC monograph not final 14 sections
Senna Liquid HUMAN OTC DRUG LABEL 1 0536-1266 LIQUID 8.80 mg ORAL OTC monograph not final 9 sections
SENEXON-S HUMAN OTC DRUG LABEL 2 0536-4086 TABLET, COATED 8.60 mg ORAL OTC monograph not final 7 sections