aceclofenac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibufenac derivatives	43	89796-99-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aceclofenac
aceclofar
hifenac

Molecular weight: 354.18
Formula: C16H13Cl2NO4
CLOGP: 4.59
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 75.63
ALOGS: -5.25
ROTB: 7

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperreflexia	82.82	39.81	18	705	5916	63482383
Apraxia	64.45	39.81	12	711	1809	63486490
Perseveration	54.81	39.81	8	715	267	63488032

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cutaneous symptom	38.68	36.72	6	411	290	34956224

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperreflexia	72.39	27.16	18	1127	8367	79734876
Apraxia	56.21	27.16	12	1133	2855	79740388
Perseveration	50.01	27.16	8	1137	389	79742854
Vitreous detachment	36.12	27.16	8	1137	2251	79740992
Cutaneous symptom	33.91	27.16	6	1139	536	79742707
Myoclonus	32.82	27.16	13	1132	27647	79715596
Tetany	29.36	27.16	7	1138	2721	79740522

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AB16	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Acetic acid derivatives and related substances
ATC	M02AA25	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatoid arthritis	indication	69896004	DOID:7148
Backache	indication	161891005
Osteoarthritis	indication	396275006
Adhesive capsulitis of shoulder	indication	399114005	DOID:14188

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.37	acidic
pKa2	1.38	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR				DRUG LABEL	SCIENTIFIC LITERATURE
Transthyretin	Secreted	P02766	TTHY_HUMAN		Kd	5.92		CHEMBL
Mitogen-activated protein kinase 1	Kinase	P28482	MK01_HUMAN		IC50	5.23		DRUG MATRIX
Aldose reductase	Enzyme		ALDR_RAT		IC50	5.89		DRUG MATRIX

External reference:

ID	Source
D01545	KEGG_DRUG
16689	RXNORM
C0050403	UMLSCUI
CHEBI:31159	CHEBI
CHEMBL93645	ChEMBL_ID
DB06736	DRUGBANK_ID
C056498	MESH_SUPPLEMENTAL_RECORD_UI
71771	PUBCHEM_CID
5608	INN_ID
RPK779R03H	UNII
329923004	SNOMEDCT_US
391703003	SNOMEDCT_US
005957	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ClanzaCR	HUMAN PRESCRIPTION DRUG LABEL	1	65697-450	TABLET, FILM COATED	200 mg	ORAL	Export only	15 sections