Florbetapir F-18 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4285 | 956103-76-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a PET agent for Abeta plaques
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 6, 2012 | FDA | AVID RADIOPHARMS INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V09AX05 | VARIOUS DIAGNOSTIC RADIOPHARMACEUTICALS CENTRAL NERVOUS SYSTEM Other central nervous system diagnostic radiopharmaceuticals |
| FDA MoA | N0000175869 | Positron Emitting Activity |
| FDA EPC | N0000177914 | Radioactive Diagnostic Agent |
| CHEBI has role | CHEBI:37336 | radioactive imaging agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Positron emission tomography | indication | 82918005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.86 | Basic |
| pKa2 | 4.25 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 10-30ML (13.5-51mCi/ML) | AMYVID | AVID RADIOPHARMS INC | N202008 | April 6, 2012 | RX | SOLUTION | INTRAVENOUS | 8506929 | April 30, 2027 | AMYVID IS A RADIOACTIVE DIAGNOSTIC AGENT FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING OF THE BRAIN TO ESTIMATE BETA-AMYLOID NEURITIC PLAQUE DENSITY IN ADULT PATIENTS WITH COGNITIVE IMPAIRMENT |
| 10-50ML (13.5-51mCi/ML) | AMYVID | AVID RADIOPHARMS INC | N202008 | April 6, 2012 | RX | SOLUTION | INTRAVENOUS | 8506929 | April 30, 2027 | AMYVID IS A RADIOACTIVE DIAGNOSTIC AGENT FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING OF THE BRAIN TO ESTIMATE BETA-AMYLOID NEURITIC PLAQUE DENSITY IN ADULT PATIENTS WITH COGNITIVE IMPAIRMENT |
| 10ML (13.5-51mCi/ML) | AMYVID | AVID RADIOPHARMS INC | N202008 | April 6, 2012 | DISCN | SOLUTION | INTRAVENOUS | 8506929 | April 30, 2027 | AMYVID IS A RADIOACTIVE DIAGNOSTIC AGENT FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING OF THE BRAIN TO ESTIMATE BETA-AMYLOID NEURITIC PLAQUE DENSITY IN ADULT PATIENTS WITH COGNITIVE IMPAIRMENT |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amyloid beta A4 protein | Unclassified | Ki | 8.54 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D09617 | KEGG_DRUG |
| 4034858 | VANDF |
| CHEBI:66880 | CHEBI |
| CHEMBL1774461 | ChEMBL_ID |
| C545186 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9193 | INN_ID |
| DB09149 | DRUGBANK_ID |
| 6W15Z5R0RU | UNII |
| 1427224 | RXNORM |
| 189354 | MMSL |
| 28499 | MMSL |
| d07859 | MMSL |
| 014294 | NDDF |
| 456994001 | SNOMEDCT_US |
| 456995000 | SNOMEDCT_US |
| C3475363 | UMLSCUI |
| 24822371 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Amyvid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-1200 | INJECTION, SOLUTION | 51 mCi | INTRAVENOUS | NDA | 27 sections |
| Amyvid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-1200 | INJECTION, SOLUTION | 51 mCi | INTRAVENOUS | NDA | 27 sections |