silicon dioxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4284 7631-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • silicon dioxide
  • silica
  • silica gel
A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.
  • Molecular weight: 60.08
  • Formula: O2Si
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 108.92 46.15 37 135 81431 2276482
Febrile neutropenia 85.47 46.15 20 152 10862 2347051
Acute myeloid leukaemia 61.50 46.15 12 160 2698 2355215

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 97.89 65.54 23 101 11077 1735580

Pharmacologic Action:

SourceCodeDescription
MeSH PA D058427 Hygroscopic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Flatulence symptom indication 308698004
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Gastrointestinal Radiography Adjunct indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024439 VUID
N0000158434 NUI
C0037098 UMLSCUI
NOCODE MMSL
4024439 VANDF
9771 RXNORM
4010521 VANDF
005872 NDDF
ETJ7Z6XBU4 UNII
DB11132 DRUGBANK_ID
CHEBI:30563 CHEBI
D012822 MESH_DESCRIPTOR_UI
D058428 MESH_DESCRIPTOR_UI
CHEMBL2068408 ChEMBL_ID
CHEMBL2108563 ChEMBL_ID
24261 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
E-Z-GAS HUMAN OTC DRUG LABEL 4 10361-793 GRANULE, EFFERVESCENT 10 mg ORAL OTC monograph final 12 sections
NANO SILVER TOOTHPASTE HUMAN OTC DRUG LABEL 3 45163-451 PASTE 14 g ORAL OTC monograph final 5 sections
BAMBOO SALT Eunganggo Jook Yeom Toothpaste HUMAN OTC DRUG LABEL 5 53208-459 PASTE 20 g DENTAL OTC monograph not final 4 sections
BAMBOO SALT Eunganggo Jook Yeom HUMAN OTC DRUG LABEL 5 53208-505 PASTE 20 g DENTAL OTC monograph not final 8 sections
Simethicone HUMAN OTC DRUG LABEL 2 54868-5620 SOLUTION/ DROPS 3.70 mg ORAL OTC MONOGRAPH FINAL 9 sections
Pediacare SIMETHICONE ANTIGAS HUMAN OTC DRUG LABEL 2 59556-853 EMULSION 0.01 g ORAL OTC monograph final 10 sections
PediaCare Gas Relief Drops Dye Free HUMAN OTC DRUG LABEL 2 63029-811 LIQUID 0.01 g ORAL OTC MONOGRAPH FINAL 9 sections
Gelusil HUMAN OTC DRUG LABEL 4 65197-300 TABLET, CHEWABLE 1 mg ORAL OTC MONOGRAPH FINAL 9 sections
2080 Dentistry Night Fresh HUMAN OTC DRUG LABEL 1 67225-0009 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 12 sections
2080 Dentistry Night Repair HUMAN OTC DRUG LABEL 1 67225-0010 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 12 sections
EVERTOX SPECIAL BATH PREPARATIONS HUMAN OTC DRUG LABEL 1 69474-1001 POWDER 20 g TOPICAL unapproved drug other 7 sections
Finefra Tooth HUMAN OTC DRUG LABEL 1 69653-050 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 1 69653-100 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 1 69653-110 PASTE, DENTIFRICE 20.25 g TOPICAL unapproved drug other 8 sections
Finefra Kids Tooth HUMAN OTC DRUG LABEL 1 69653-120 PASTE, DENTIFRICE 9.10 g TOPICAL unapproved drug other 8 sections
Alegria Neo HUMAN OTC DRUG LABEL 2 70406-020 PASTE, DENTIFRICE 2.80 g TOPICAL unapproved drug other 8 sections
Olea Olidental HUMAN OTC DRUG LABEL 1 70417-002 PASTE 170 mg ORAL unapproved drug other 7 sections
Chunzam Silk Amino Acid Tooth HUMAN OTC DRUG LABEL 3 71078-0001 PASTE, DENTIFRICE 4 g DENTAL unapproved drug other 7 sections
SONATURAL ALL KILL BLACKHEAD CLEAR HUMAN OTC DRUG LABEL 1 71322-160 STICK 0.88 g TOPICAL unapproved drug other 9 sections
Purigo HUMAN OTC DRUG LABEL 2 71710-0001 LIQUID 31 g TOPICAL unapproved drug other 5 sections
OPRECARE 12 HUMAN OTC DRUG LABEL 1 71764-101 GEL 1.71 g DENTAL unapproved drug other 8 sections
OPRECARE 24 HUMAN OTC DRUG LABEL 1 71764-103 GEL 1.43 g DENTAL unapproved drug other 8 sections
OPRECARE 3SET (07,12,21) HUMAN OTC DRUG LABEL 3 71764-104 KIT 1.71 g None unapproved drug other 8 sections
LACSIAN new perfect all care tooth HUMAN OTC DRUG LABEL 2 72048-030 PASTE, DENTIFRICE 18 g TOPICAL unapproved drug other 8 sections
Dr.Pauhls TOOTHPAST E LIME MANDARIN FLAVOR HUMAN OTC DRUG LABEL 2 72265-010 PASTE, DENTIFRICE 13 g TOPICAL unapproved drug other 8 sections
Dr.Pauhls TOOTHPAST E PATCHOULI MUSK FLAVOR HUMAN OTC DRUG LABEL 2 72265-020 PASTE, DENTIFRICE 13 g TOPICAL unapproved drug other 8 sections
Dr.Pauhls TOOTHPAST E VANILLE BLACK TEA FLAVOR HUMAN OTC DRUG LABEL 2 72265-030 PASTE, DENTIFRICE 13 g TOPICAL unapproved drug other 8 sections
MediF Tooth HUMAN OTC DRUG LABEL 1 72346-010 PASTE, DENTIFRICE 18.20 g TOPICAL unapproved drug other 8 sections
28TAK DOUX TOOTH HUMAN OTC DRUG LABEL 1 72440-010 PASTE, DENTIFRICE 4.80 g ORAL unapproved drug other 8 sections
28TAK CLAIR TOOTH HUMAN OTC DRUG LABEL 2 72440-020 PASTE, DENTIFRICE 4.80 g ORAL unapproved drug other 8 sections