silicon dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4284 7631-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • silicon dioxide
  • silica
  • silica gel
A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.
  • Molecular weight: 60.08
  • Formula: O2Si
  • CLOGP: -1.75
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 101.06 15.44 81 4949 97586 50502508
Myelosuppression 58.45 15.44 28 5002 13489 50586605
Hepatic function abnormal 49.18 15.44 34 4996 32647 50567447
Platelet count decreased 37.39 15.44 48 4982 100678 50499416
Neutrophil count decreased 36.86 15.44 33 4997 45993 50554101
Exposure to toxic agent 33.88 15.44 13 5017 3645 50596449
Liver disorder 26.51 15.44 25 5005 37197 50562897
Acute myeloid leukaemia 21.07 15.44 15 5015 15059 50585035
Skin lesion 21.06 15.44 19 5011 26708 50573386
Laryngeal inflammation 18.75 15.44 4 5026 133 50599961
Atrioventricular conduction time shortened 18.41 15.44 3 5027 21 50600073
Blood electrolytes increased 17.37 15.44 3 5027 31 50600063
Joint stiffness 17.21 15.44 18 5012 30290 50569804
Elliptocytosis 16.96 15.44 3 5027 36 50600058
Rectal lesion 16.10 15.44 3 5027 49 50600045

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 86.91 19.44 83 3233 112157 29459054
Myelosuppression 86.49 19.44 37 3279 12190 29559021
Hepatic function abnormal 42.11 19.44 35 3281 39224 29531987
Platelet count decreased 38.90 19.44 53 3263 104619 29466592
CADASIL 33.60 19.44 6 3310 67 29571144
Magnetic resonance imaging spinal abnormal 33.28 19.44 6 3310 71 29571140
Visual evoked potentials abnormal 32.90 19.44 6 3310 76 29571135
Central nervous system inflammation 31.31 19.44 6 3310 101 29571110
Physical examination abnormal 31.01 19.44 7 3309 268 29570943
Saccadic eye movement 29.87 19.44 6 3310 130 29571081
Cerebral microangiopathy 28.29 19.44 6 3310 171 29571040
Double stranded DNA antibody positive 27.90 19.44 6 3310 183 29571028
Lipid metabolism disorder 24.87 19.44 6 3310 308 29570903
Acute myeloid leukaemia 24.83 19.44 18 3298 16495 29554716
Creatinine renal clearance increased 22.98 19.44 6 3310 425 29570786
Exposure to toxic agent 22.26 19.44 9 3307 2566 29568645
Infection susceptibility increased 20.84 19.44 6 3310 612 29570599
White matter lesion 20.54 19.44 6 3310 644 29570567
Spondylolisthesis 20.14 19.44 6 3310 690 29570521
CSF protein increased 19.90 19.44 6 3310 719 29570492

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 197.51 15.75 161 6653 187496 64304422
Myelosuppression 149.13 15.75 65 6749 23765 64468153
Hepatic function abnormal 95.70 15.75 68 6746 64245 64427673
Platelet count decreased 79.33 15.75 93 6721 167618 64324300
Exposure to toxic agent 56.14 15.75 22 6792 6137 64485781
Neutrophil count decreased 50.78 15.75 51 6763 77145 64414773
Acute myeloid leukaemia 47.78 15.75 32 6782 27431 64464487
Liver disorder 40.23 15.75 38 6776 53313 64438605
Death 29.00 15.75 114 6700 482591 64009327
Renal disorder 22.56 15.75 23 6791 35342 64456576
Pneumonia 22.24 15.75 117 6697 559459 63932459
Bronchopulmonary aspergillosis 21.28 15.75 17 6797 19068 64472850
Electrocardiogram QT prolonged 20.62 15.75 33 6781 79415 64412503
Pneumonia fungal 19.54 15.75 12 6802 8865 64483053
White blood cell count decreased 18.45 15.75 47 6767 157790 64334128
Atrioventricular conduction time shortened 18.23 15.75 3 6811 21 64491897
Drug ineffective 17.88 15.75 39 6775 840208 63651710
Laryngeal inflammation 17.06 15.75 4 6810 193 64491725
Blast cell count increased 16.90 15.75 6 6808 1273 64490645
Bone marrow failure 16.89 15.75 23 6791 47929 64443989
Sepsis 16.79 15.75 58 6756 230283 64261635
Elliptocytosis 16.78 15.75 3 6811 36 64491882

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D058427 Hygroscopic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Flatulence symptom indication 308698004
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Gastrointestinal Radiography Adjunct indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024439 VUID
N0000158434 NUI
4010521 VANDF
4020878 VANDF
4024439 VANDF
C0037098 UMLSCUI
CHEBI:30563 CHEBI
CHEMBL2108563 ChEMBL_ID
D012822 MESH_DESCRIPTOR_UI
DB11132 DRUGBANK_ID
ETJ7Z6XBU4 UNII
24261 PUBCHEM_CID
9771 RXNORM
NOCODE MMSL
005872 NDDF
D058428 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
E-Z-GASII HUMAN OTC DRUG LABEL 4 10361-793 GRANULE, EFFERVESCENT 10 mg ORAL OTC monograph final 11 sections
SILICEA HUMAN OTC DRUG LABEL 1 44911-0183 LIQUID 200 [hp_C] ORAL unapproved homeopathic 9 sections
Silicea HUMAN OTC DRUG LABEL 1 44911-0186 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
DizzinessHP HUMAN OTC DRUG LABEL 9 44911-0187 LIQUID 30 [hp_X] ORAL unapproved homeopathic 9 sections
NANO SILVER TOOTHPASTE HUMAN OTC DRUG LABEL 3 45163-451 PASTE 14 g ORAL OTC monograph final 5 sections
Type 3 Sinus Max HUMAN OTC DRUG LABEL 4 50169-0005 TABLET, ORALLY DISINTEGRATING 200 [hp_C] ORAL unapproved drug other 9 sections
BAMBOO SALT Eunganggo Jook Yeom Toothpaste HUMAN OTC DRUG LABEL 7 53208-459 PASTE 20 g DENTAL OTC monograph not final 4 sections
BAMBOO SALT Eunganggo Jook Yeom HUMAN OTC DRUG LABEL 7 53208-505 PASTE 20 g DENTAL OTC monograph not final 8 sections
Simethicone HUMAN OTC DRUG LABEL 2 54868-5620 SOLUTION/ DROPS 3.70 mg ORAL OTC MONOGRAPH FINAL 8 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-3112 TABLET 30 [hp_X] ORAL unapproved homeopathic 12 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-8081 TABLET 6 [hp_X] ORAL unapproved homeopathic 12 sections
10 Parasite Detox HUMAN OTC DRUG LABEL 15 55146-010 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
CS Bone HUMAN OTC DRUG LABEL 11 57955-0211 LIQUID 10 [hp_X] ORAL unapproved homeopathic 9 sections
Pediacare SIMETHICONE ANTIGAS HUMAN OTC DRUG LABEL 2 59556-853 EMULSION 0.01 g ORAL OTC monograph final 11 sections
PediaCare Gas Relief Drops Dye Free HUMAN OTC DRUG LABEL 2 63029-811 LIQUID 0.01 g ORAL OTC MONOGRAPH FINAL 11 sections
Gelusil HUMAN OTC DRUG LABEL 4 65197-300 TABLET, CHEWABLE 1 mg ORAL OTC monograph final 13 sections
2080 Dentistry Night Fresh HUMAN OTC DRUG LABEL 1 67225-0009 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
2080 Dentistry Night Repair HUMAN OTC DRUG LABEL 1 67225-0010 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
EVERTOX SPECIAL BATH PREPARATIONS HUMAN OTC DRUG LABEL 1 69474-1001 POWDER 20 g TOPICAL unapproved drug other 7 sections
Finefra Tooth HUMAN OTC DRUG LABEL 2 69653-050 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-100 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-110 PASTE, DENTIFRICE 20.25 g TOPICAL unapproved drug other 8 sections
Finefra Kids Tooth HUMAN OTC DRUG LABEL 2 69653-120 PASTE, DENTIFRICE 9.10 g TOPICAL unapproved drug other 8 sections
Alegria Neo HUMAN OTC DRUG LABEL 2 70406-020 PASTE, DENTIFRICE 2.80 g TOPICAL unapproved drug other 8 sections
Olea Olidental HUMAN OTC DRUG LABEL 1 70417-002 PASTE 170 mg ORAL unapproved drug other 8 sections
Mongdies raspberry baby tooth HUMAN OTC DRUG LABEL 1 70477-080 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Exoden Cavity HUMAN OTC DRUG LABEL 3 70602-005 PASTE 15 g TOPICAL unapproved drug other 8 sections
Exoden Sensitive HUMAN OTC DRUG LABEL 2 70602-006 PASTE 2.50 g TOPICAL unapproved drug other 8 sections
Exoden Gum HUMAN OTC DRUG LABEL 2 70602-007 PASTE 15 g TOPICAL unapproved drug other 8 sections
Exoden White HUMAN OTC DRUG LABEL 2 70602-008 PASTE 15 g TOPICAL unapproved drug other 8 sections