silicon dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4284 7631-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • silicon dioxide
  • silica
  • silica gel
A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.
  • Molecular weight: 60.08
  • Formula: O2Si
  • CLOGP: -1.75
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 101.36 15.30 81 5074 105464 56181448
Acute myeloid leukaemia 60.44 15.30 30 5125 16942 56269970
Myelosuppression 53.84 15.30 28 5127 17427 56269485
Hepatic function abnormal 49.98 15.30 34 5121 34524 56252388
Platelet count decreased 38.43 15.30 48 5107 106335 56180577
Neutrophil count decreased 36.94 15.30 33 5122 49789 56237123
Exposure to toxic agent 34.84 15.30 13 5142 3665 56283247
Liver disorder 24.53 15.30 25 5130 44345 56242567
Skin lesion 21.57 15.30 19 5136 28116 56258796
Laryngeal inflammation 19.07 15.30 4 5151 133 56286779
Atrioventricular conduction time shortened 18.66 15.30 3 5152 21 56286891
Joint stiffness 17.85 15.30 19 5136 35406 56251506
Blood electrolytes increased 17.62 15.30 3 5152 31 56286881
White blood cell count decreased 16.56 15.30 36 5119 125954 56160958
Rectal lesion 16.23 15.30 3 5152 51 56286861
Elliptocytosis 15.50 15.30 3 5152 66 56286846

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 80.60 19.01 83 3496 121766 31571999
Myelosuppression 79.17 19.01 37 3542 14883 31678882
Respiratory tract infection bacterial 66.61 19.01 18 3561 1448 31692317
Respiratory tract infection viral 60.96 19.01 18 3561 1996 31691769
Platelet count decreased 53.52 19.01 64 3515 110371 31583394
Acute myeloid leukaemia 49.23 19.01 29 3550 18643 31675122
Hepatic function abnormal 40.40 19.01 35 3544 41187 31652578
CADASIL 33.55 19.01 6 3573 67 31693698
Magnetic resonance imaging spinal abnormal 33.24 19.01 6 3573 71 31693694
Visual evoked potentials abnormal 32.86 19.01 6 3573 76 31693689
Central nervous system inflammation 31.26 19.01 6 3573 101 31693664
Respiratory tract infection 30.59 19.01 21 3558 17540 31676225
Physical examination abnormal 30.38 19.01 7 3572 292 31693473
Saccadic eye movement 28.86 19.01 6 3573 154 31693611
Cerebral microangiopathy 27.80 19.01 6 3573 185 31693580
Double stranded DNA antibody positive 27.43 19.01 6 3573 197 31693568
Lipid metabolism disorder 24.64 19.01 6 3573 318 31693447
Creatinine renal clearance increased 22.85 19.01 6 3573 432 31693333
Exposure to toxic agent 22.13 19.01 9 3570 2586 31691179
Infection susceptibility increased 20.37 19.01 6 3573 659 31693106
Cytokine release syndrome 20.18 19.01 16 3563 16626 31677139
White matter lesion 20.07 19.01 6 3573 693 31693072
Spondylolisthesis 20.05 19.01 6 3573 696 31693069
CSF protein increased 19.33 19.01 6 3573 786 31692979

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 191.83 16.59 161 7000 204157 70717126
Myelosuppression 137.30 16.59 65 7096 30080 70891203
Acute myeloid leukaemia 108.95 16.59 56 7105 30884 70890399
Platelet count decreased 96.97 16.59 104 7057 178118 70743165
Hepatic function abnormal 95.06 16.59 68 7093 67928 70853355
Respiratory tract infection bacterial 65.56 16.59 18 7143 1719 70919564
Exposure to toxic agent 56.99 16.59 22 7139 6172 70915111
Respiratory tract infection viral 52.92 16.59 18 7143 3523 70917760
Neutrophil count decreased 49.33 16.59 51 7110 83505 70837778
Liver disorder 37.08 16.59 38 7123 61530 70859753
Death 29.99 16.59 116 7045 509945 70411338
Acute myeloid leukaemia refractory 25.13 16.59 5 7156 115 70921168
Pneumonia 23.94 16.59 121 7040 596111 70325172
Renal disorder 22.05 16.59 23 7138 37986 70883297
Respiratory tract infection 21.68 16.59 24 7137 42374 70878909
Acute myeloid leukaemia recurrent 21.68 16.59 9 7152 3045 70918238
Cytokine release syndrome 20.96 16.59 19 7142 26448 70894835
Drug ineffective 20.54 16.59 40 7121 939712 69981571
Bronchopulmonary aspergillosis 20.52 16.59 17 7144 20985 70900298
Electrocardiogram QT prolonged 20.50 16.59 33 7128 83484 70837799
Pyrexia 20.17 16.59 117 7044 606835 70314448
Pneumonia fungal 18.77 16.59 12 7149 9941 70911342
White blood cell count decreased 18.57 16.59 48 7113 170093 70751190
Anaemia 18.40 16.59 85 7076 403338 70517945
Atrioventricular conduction time shortened 18.37 16.59 3 7158 21 70921262
Bone marrow failure 17.31 16.59 23 7138 48987 70872296
Laryngeal inflammation 17.20 16.59 4 7157 195 70921088
Blast cell count increased 16.90 16.59 6 7155 1331 70919952

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D058427 Hygroscopic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Flatulence symptom indication 308698004
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Gastrointestinal Radiography Adjunct indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024439 VUID
N0000158434 NUI
4010521 VANDF
4020878 VANDF
4024439 VANDF
C0037098 UMLSCUI
CHEBI:30563 CHEBI
CHEMBL2108563 ChEMBL_ID
D012822 MESH_DESCRIPTOR_UI
DB11132 DRUGBANK_ID
ETJ7Z6XBU4 UNII
24261 PUBCHEM_CID
9771 RXNORM
NOCODE MMSL
005872 NDDF
D058428 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
E-Z-GASII HUMAN OTC DRUG LABEL 4 10361-793 GRANULE, EFFERVESCENT 10 mg ORAL OTC monograph final 11 sections
SILICEA HUMAN OTC DRUG LABEL 1 44911-0183 LIQUID 200 [hp_C] ORAL unapproved homeopathic 9 sections
Silicea HUMAN OTC DRUG LABEL 1 44911-0186 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
DizzinessHP HUMAN OTC DRUG LABEL 9 44911-0187 LIQUID 30 [hp_X] ORAL unapproved homeopathic 9 sections
NANO SILVER TOOTHPASTE HUMAN OTC DRUG LABEL 3 45163-451 PASTE 14 g ORAL OTC monograph final 5 sections
Type 3 Sinus Max HUMAN OTC DRUG LABEL 4 50169-0005 TABLET, ORALLY DISINTEGRATING 200 [hp_C] ORAL unapproved drug other 9 sections
BAMBOO SALT Eunganggo Jook Yeom Toothpaste HUMAN OTC DRUG LABEL 7 53208-459 PASTE 20 g DENTAL OTC monograph not final 4 sections
BAMBOO SALT Eunganggo Jook Yeom HUMAN OTC DRUG LABEL 7 53208-505 PASTE 20 g DENTAL OTC monograph not final 8 sections
Simethicone HUMAN OTC DRUG LABEL 2 54868-5620 SOLUTION/ DROPS 3.70 mg ORAL OTC MONOGRAPH FINAL 8 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-3112 TABLET 30 [hp_X] ORAL unapproved homeopathic 12 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-8081 TABLET 6 [hp_X] ORAL unapproved homeopathic 12 sections
10 Parasite Detox HUMAN OTC DRUG LABEL 15 55146-010 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
CS Bone HUMAN OTC DRUG LABEL 11 57955-0211 LIQUID 10 [hp_X] ORAL unapproved homeopathic 9 sections
Pediacare SIMETHICONE ANTIGAS HUMAN OTC DRUG LABEL 2 59556-853 EMULSION 0.01 g ORAL OTC monograph final 11 sections
PediaCare Gas Relief Drops Dye Free HUMAN OTC DRUG LABEL 2 63029-811 LIQUID 0.01 g ORAL OTC MONOGRAPH FINAL 11 sections
Gelusil HUMAN OTC DRUG LABEL 4 65197-300 TABLET, CHEWABLE 1 mg ORAL OTC monograph final 13 sections
2080 Dentistry Night Fresh HUMAN OTC DRUG LABEL 1 67225-0009 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
2080 Dentistry Night Repair HUMAN OTC DRUG LABEL 1 67225-0010 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
EVERTOX SPECIAL BATH PREPARATIONS HUMAN OTC DRUG LABEL 1 69474-1001 POWDER 20 g TOPICAL unapproved drug other 7 sections
Finefra Tooth HUMAN OTC DRUG LABEL 2 69653-050 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-100 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-110 PASTE, DENTIFRICE 20.25 g TOPICAL unapproved drug other 8 sections
Finefra Kids Tooth HUMAN OTC DRUG LABEL 2 69653-120 PASTE, DENTIFRICE 9.10 g TOPICAL unapproved drug other 8 sections
Alegria Neo HUMAN OTC DRUG LABEL 2 70406-020 PASTE, DENTIFRICE 2.80 g TOPICAL unapproved drug other 8 sections
Olea Olidental HUMAN OTC DRUG LABEL 1 70417-002 PASTE 170 mg ORAL unapproved drug other 8 sections
Mongdies raspberry baby tooth HUMAN OTC DRUG LABEL 1 70477-080 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Exoden Cavity HUMAN OTC DRUG LABEL 3 70602-005 PASTE 15 g TOPICAL unapproved drug other 8 sections
Exoden Sensitive HUMAN OTC DRUG LABEL 2 70602-006 PASTE 2.50 g TOPICAL unapproved drug other 8 sections
Exoden Gum HUMAN OTC DRUG LABEL 2 70602-007 PASTE 15 g TOPICAL unapproved drug other 8 sections
Exoden White HUMAN OTC DRUG LABEL 2 70602-008 PASTE 15 g TOPICAL unapproved drug other 8 sections