silicon dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4284 7631-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • silicon dioxide
  • silica
  • silica gel
A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.
  • Molecular weight: 60.08
  • Formula: O2Si
  • CLOGP: -1.75
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 99.84 15.85 81 5210 118368 63365363
Hepatic function abnormal 50.67 15.85 34 5257 37108 63446623
Myelosuppression 48.28 15.85 28 5263 23675 63460056
Platelet count decreased 38.69 15.85 48 5243 116074 63367657
Neutrophil count decreased 36.09 15.85 33 5258 56373 63427358
Exposure to toxic agent 30.76 15.85 13 5278 5574 63478157
Liver disorder 22.53 15.85 25 5266 53662 63430069
Acute myeloid leukaemia 21.71 15.85 15 5276 17132 63466599
Skin lesion 21.67 15.85 19 5272 30702 63453029
Laryngeal inflammation 19.28 15.85 4 5287 139 63483592
Atrioventricular conduction time shortened 18.94 15.85 3 5288 21 63483710
Blood electrolytes increased 17.90 15.85 3 5288 31 63483700
Joint stiffness 16.71 15.85 19 5272 41850 63441881
White blood cell count decreased 16.44 15.85 36 5255 139068 63344663
Rectal lesion 16.35 15.85 3 5288 54 63483677
Drug intolerance 16.33 15.85 3 5288 308658 63175073

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 78.76 19.23 83 3526 136766 34816556
Myelosuppression 73.32 19.23 37 3572 19228 34934094
Respiratory tract infection bacterial 64.73 19.23 18 3591 1764 34951558
Respiratory tract infection viral 58.59 19.23 18 3591 2499 34950823
Platelet count decreased 53.98 19.23 64 3545 119653 34833669
Hepatic function abnormal 40.89 19.23 35 3574 44328 34908994
Visual evoked potentials abnormal 33.39 19.23 6 3603 76 34953246
CADASIL 31.21 19.23 6 3603 112 34953210
Physical examination abnormal 30.53 19.23 7 3602 313 34953009
Respiratory tract infection 30.10 19.23 21 3588 19691 34933631
Magnetic resonance imaging spinal abnormal 29.90 19.23 6 3603 141 34953181
Saccadic eye movement 28.72 19.23 6 3603 173 34953149
Cerebral microangiopathy 28.00 19.23 6 3603 196 34953126
Double stranded DNA antibody positive 27.51 19.23 6 3603 213 34953109
Central nervous system inflammation 27.12 19.23 6 3603 228 34953094
Lipid metabolism disorder 24.61 19.23 6 3603 350 34952972
Acute myeloid leukaemia 24.53 19.23 18 3591 18252 34935070
Creatinine renal clearance increased 23.16 19.23 6 3603 448 34952874
Infection susceptibility increased 20.50 19.23 6 3603 705 34952617
Spondylolisthesis 19.97 19.23 6 3603 771 34952551
Exposure to toxic agent 19.89 19.23 9 3600 3666 34949656
White matter lesion 19.70 19.23 6 3603 808 34952514
CSF protein increased 19.61 19.23 6 3603 820 34952502

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 188.94 16.42 161 7107 230838 79506282
Myelosuppression 125.71 16.42 65 7203 40231 79696889
Platelet count decreased 98.18 16.42 104 7164 194560 79542560
Hepatic function abnormal 96.88 16.42 68 7200 73039 79664081
Respiratory tract infection bacterial 64.20 16.42 18 7250 2059 79735061
Respiratory tract infection viral 51.47 16.42 18 7250 4241 79732879
Exposure to toxic agent 50.84 16.42 22 7246 9136 79727984
Neutrophil count decreased 48.69 16.42 51 7217 93908 79643212
Acute myeloid leukaemia 48.66 16.42 32 7236 30853 79706267
Liver disorder 35.19 16.42 38 7230 72379 79664741
Death 30.64 16.42 117 7151 566397 79170723
Pneumonia 24.67 16.42 122 7146 660124 79076996
Drug ineffective 22.70 16.42 40 7228 1080873 78656247
Renal disorder 22.05 16.42 23 7245 42082 79695038
Bronchopulmonary aspergillosis 21.16 16.42 17 7251 22277 79714843
Electrocardiogram QT prolonged 21.08 16.42 33 7235 90353 79646767
Respiratory tract infection 20.98 16.42 24 7244 48665 79688455
Pyrexia 20.29 16.42 118 7150 678591 79058529
Anaemia 19.34 16.42 86 7182 444929 79292191
Atrioventricular conduction time shortened 18.67 16.42 3 7265 21 79737099
White blood cell count decreased 18.60 16.42 48 7220 188240 79548880
Pneumonia fungal 18.59 16.42 12 7256 11198 79725922
Bone marrow failure 18.41 16.42 23 7245 51084 79686036
Cytokine release syndrome 17.67 16.42 19 7249 35979 79701141
Laryngeal inflammation 17.37 16.42 4 7264 207 79736913
Blast cell count increased 17.19 16.42 6 7262 1404 79735716
Sepsis 16.48 16.42 58 7210 269370 79467750

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D058427 Hygroscopic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Flatulence symptom indication 308698004
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Gastrointestinal Radiography Adjunct indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024439 VUID
N0000158434 NUI
4010521 VANDF
4020878 VANDF
4024439 VANDF
C0037098 UMLSCUI
CHEBI:30563 CHEBI
CHEMBL2108563 ChEMBL_ID
D012822 MESH_DESCRIPTOR_UI
DB11132 DRUGBANK_ID
ETJ7Z6XBU4 UNII
24261 PUBCHEM_CID
9771 RXNORM
NOCODE MMSL
005872 NDDF
D058428 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
E-Z-GASII HUMAN OTC DRUG LABEL 4 10361-793 GRANULE, EFFERVESCENT 10 mg ORAL OTC monograph final 11 sections
E-Z-GASII HUMAN OTC DRUG LABEL 4 10361-793 GRANULE, EFFERVESCENT 10 mg ORAL OTC monograph final 11 sections
SILICEA HUMAN OTC DRUG LABEL 1 44911-0183 LIQUID 200 [hp_C] ORAL unapproved homeopathic 9 sections
Silicea HUMAN OTC DRUG LABEL 1 44911-0186 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
DizzinessHP HUMAN OTC DRUG LABEL 9 44911-0187 LIQUID 30 [hp_X] ORAL unapproved homeopathic 9 sections
NANO SILVER TOOTHPASTE HUMAN OTC DRUG LABEL 3 45163-451 PASTE 14 g ORAL OTC monograph final 10 sections
Type 3 Sinus Max HUMAN OTC DRUG LABEL 4 50169-0005 TABLET, ORALLY DISINTEGRATING 200 [hp_C] ORAL unapproved drug other 9 sections
BAMBOO SALT Eunganggo Jook Yeom Toothpaste HUMAN OTC DRUG LABEL 7 53208-459 PASTE 20 g DENTAL OTC monograph not final 8 sections
BAMBOO SALT Eunganggo Jook Yeom HUMAN OTC DRUG LABEL 7 53208-505 PASTE 20 g DENTAL OTC monograph not final 8 sections
Simethicone HUMAN OTC DRUG LABEL 2 54868-5620 SOLUTION/ DROPS 3.70 mg ORAL OTC MONOGRAPH FINAL 8 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-3112 TABLET 30 [hp_X] ORAL unapproved homeopathic 12 sections
SILICEA HUMAN OTC DRUG LABEL 1 54973-8081 TABLET 6 [hp_X] ORAL unapproved homeopathic 12 sections
10 Parasite Detox HUMAN OTC DRUG LABEL 15 55146-010 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
CS Bone HUMAN OTC DRUG LABEL 11 57955-0211 LIQUID 10 [hp_X] ORAL unapproved homeopathic 9 sections
Pediacare SIMETHICONE ANTIGAS HUMAN OTC DRUG LABEL 2 59556-853 EMULSION 0.01 g ORAL OTC monograph final 11 sections
PediaCare Gas Relief Drops Dye Free HUMAN OTC DRUG LABEL 2 63029-811 LIQUID 0.01 g ORAL OTC MONOGRAPH FINAL 11 sections
Gelusil HUMAN OTC DRUG LABEL 4 65197-300 TABLET, CHEWABLE 1 mg ORAL OTC monograph final 13 sections
Gelusil HUMAN OTC DRUG LABEL 4 65197-300 TABLET, CHEWABLE 1 mg ORAL OTC monograph final 13 sections
2080 Dentistry Night Fresh HUMAN OTC DRUG LABEL 1 67225-0009 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
2080 Dentistry Night Repair HUMAN OTC DRUG LABEL 1 67225-0010 PASTE, DENTIFRICE 15 g DENTAL OTC monograph final 13 sections
EVERTOX SPECIAL BATH PREPARATIONS HUMAN OTC DRUG LABEL 1 69474-1001 POWDER 20 g TOPICAL unapproved drug other 7 sections
Finefra Tooth HUMAN OTC DRUG LABEL 2 69653-050 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-100 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Finefra Black Tooth HUMAN OTC DRUG LABEL 2 69653-110 PASTE, DENTIFRICE 20.25 g TOPICAL unapproved drug other 8 sections
Finefra Kids Tooth HUMAN OTC DRUG LABEL 2 69653-120 PASTE, DENTIFRICE 9.10 g TOPICAL unapproved drug other 8 sections
Alegria Neo HUMAN OTC DRUG LABEL 2 70406-020 PASTE, DENTIFRICE 2.80 g TOPICAL unapproved drug other 8 sections
Olea Olidental HUMAN OTC DRUG LABEL 1 70417-002 PASTE 170 mg ORAL unapproved drug other 8 sections
Mongdies raspberry baby tooth HUMAN OTC DRUG LABEL 1 70477-080 PASTE, DENTIFRICE 15 g TOPICAL unapproved drug other 8 sections
Exoden Cavity HUMAN OTC DRUG LABEL 3 70602-005 PASTE 15 g TOPICAL unapproved drug other 8 sections
Exoden Sensitive HUMAN OTC DRUG LABEL 2 70602-006 PASTE 2.50 g TOPICAL unapproved drug other 8 sections