silicon dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4284	7631-86-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: silicon dioxide silica silica gel	A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID. Molecular weight: 60.08 Formula: O2Si CLOGP: -1.75 LIPINSKI: None HAC: 2 HDO: 0 TPSA: 34.14 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

silicon dioxide
silica
silica gel

A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.

Molecular weight: 60.08
Formula: O2Si
CLOGP: -1.75
LIPINSKI: None
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	99.84	15.85	81	5210	118368	63365363
Hepatic function abnormal	50.67	15.85	34	5257	37108	63446623
Myelosuppression	48.28	15.85	28	5263	23675	63460056
Platelet count decreased	38.69	15.85	48	5243	116074	63367657
Neutrophil count decreased	36.09	15.85	33	5258	56373	63427358
Exposure to toxic agent	30.76	15.85	13	5278	5574	63478157
Liver disorder	22.53	15.85	25	5266	53662	63430069
Acute myeloid leukaemia	21.71	15.85	15	5276	17132	63466599
Skin lesion	21.67	15.85	19	5272	30702	63453029
Laryngeal inflammation	19.28	15.85	4	5287	139	63483592

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	78.76	19.23	83	3526	136766	34816556
Myelosuppression	73.32	19.23	37	3572	19228	34934094
Respiratory tract infection bacterial	64.73	19.23	18	3591	1764	34951558
Respiratory tract infection viral	58.59	19.23	18	3591	2499	34950823
Platelet count decreased	53.98	19.23	64	3545	119653	34833669
Hepatic function abnormal	40.89	19.23	35	3574	44328	34908994
Visual evoked potentials abnormal	33.39	19.23	6	3603	76	34953246
CADASIL	31.21	19.23	6	3603	112	34953210
Physical examination abnormal	30.53	19.23	7	3602	313	34953009
Respiratory tract infection	30.10	19.23	21	3588	19691	34933631

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	188.94	16.42	161	7107	230838	79506282
Myelosuppression	125.71	16.42	65	7203	40231	79696889
Platelet count decreased	98.18	16.42	104	7164	194560	79542560
Hepatic function abnormal	96.88	16.42	68	7200	73039	79664081
Respiratory tract infection bacterial	64.20	16.42	18	7250	2059	79735061
Respiratory tract infection viral	51.47	16.42	18	7250	4241	79732879
Exposure to toxic agent	50.84	16.42	22	7246	9136	79727984
Neutrophil count decreased	48.69	16.42	51	7217	93908	79643212
Acute myeloid leukaemia	48.66	16.42	32	7236	30853	79706267
Liver disorder	35.19	16.42	38	7230	72379	79664741

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D058427	Hygroscopic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Heartburn	indication	16331000
Indigestion	indication	162031009
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Flatulence symptom	indication	308698004
Gastric Hypersecretory Conditions	indication
Hiatal Hernia with Reflux Esophagitis	indication
Gastrointestinal Radiography Adjunct	indication
Multiple endocrine adenomas	off-label use	60549007
Systemic mast cell disease	off-label use	397016004	DOID:349

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
005872	NDDF
24261	PUBCHEM_CID
4010521	VANDF
4020878	VANDF
4024439	VUID
4024439	VANDF
9771	RXNORM
C0037098	UMLSCUI
CHEBI:30563	CHEBI
CHEMBL2108563	ChEMBL_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
10 Parasite Detox	HUMAN OTC DRUG LABEL	15	55146-010	LIQUID	30 [hp_C]	ORAL	unapproved homeopathic	9 sections
2080 Dentistry Night Fresh	HUMAN OTC DRUG LABEL	1	67225-0009	PASTE, DENTIFRICE	15 g	DENTAL	OTC monograph final	13 sections
2080 Dentistry Night Repair	HUMAN OTC DRUG LABEL	1	67225-0010	PASTE, DENTIFRICE	15 g	DENTAL	OTC monograph final	13 sections
Alegria Neo	HUMAN OTC DRUG LABEL	2	70406-020	PASTE, DENTIFRICE	2.80 g	TOPICAL	unapproved drug other	8 sections
BAMBOO SALT Eunganggo Jook Yeom	HUMAN OTC DRUG LABEL	7	53208-505	PASTE	20 g	DENTAL	OTC monograph not final	8 sections
BAMBOO SALT Eunganggo Jook Yeom Toothpaste	HUMAN OTC DRUG LABEL	7	53208-459	PASTE	20 g	DENTAL	OTC monograph not final	8 sections
CS Bone	HUMAN OTC DRUG LABEL	11	57955-0211	LIQUID	10 [hp_X]	ORAL	unapproved homeopathic	9 sections
DizzinessHP	HUMAN OTC DRUG LABEL	9	44911-0187	LIQUID	30 [hp_X]	ORAL	unapproved homeopathic	9 sections
E-Z-GASII	HUMAN OTC DRUG LABEL	4	10361-793	GRANULE, EFFERVESCENT	10 mg	ORAL	OTC monograph final	11 sections
E-Z-GASII	HUMAN OTC DRUG LABEL	4	10361-793	GRANULE, EFFERVESCENT	10 mg	ORAL	OTC monograph final	11 sections

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