tocofersolan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4280	59-02-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tocophersolan .ALPHA.-TOCOPHEROL, D- alpha-tocopherol alpha-D-Tocopherol syntopherol ALPHA-TOCOPHEROL, D- .ALPHA.-TOCOPHEROL d-alpha-tocopherol alpha-tocopherol, dl- .Alpha.-tocopherol, DL- tocofersolan vedrop	A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture. Molecular weight: 430.72 Formula: C29H50O2 CLOGP: 12 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 29.46 ALOGS: -7.79 ROTB: 12 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tocophersolan
.ALPHA.-TOCOPHEROL, D-
alpha-tocopherol
alpha-D-Tocopherol
syntopherol
ALPHA-TOCOPHEROL, D-
.ALPHA.-TOCOPHEROL
d-alpha-tocopherol
alpha-tocopherol, dl-
.Alpha.-tocopherol, DL-
tocofersolan
vedrop

A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.

Molecular weight: 430.72
Formula: C29H50O2
CLOGP: 12
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 29.46
ALOGS: -7.79
ROTB: 12

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	274.47	12.94	160	29523	24216	63435123
Muscle spasticity	162.06	12.94	110	29573	21684	63437655
Electric shock	111.02	12.94	36	29647	1284	63458055
Therapy cessation	107.33	12.94	99	29584	30358	63428981
Ear pain	103.90	12.94	105	29578	36013	63423326
Body temperature increased	97.74	12.94	103	29580	37089	63422250
Night sweats	85.95	12.94	110	29573	48704	63410635
Respiratory disorder	83.30	12.94	97	29586	38985	63420354
Chronic sinusitis	81.87	12.94	59	29624	12784	63446555
Back pain	79.82	12.94	288	29395	263857	63195482
Intervertebral discitis	79.72	12.94	36	29647	3192	63456147
Peripheral swelling	76.18	12.94	285	29398	265657	63193682
Post-traumatic stress disorder	71.33	12.94	39	29644	5212	63454127
Insomnia	64.39	12.94	234	29449	215018	63244321
Paraesthesia oral	62.86	12.94	60	29623	19196	63440143
Pneumonia aspiration	62.64	12.94	79	29604	34461	63424878
Temperature intolerance	61.33	12.94	43	29640	8921	63450418
Weight decreased	59.80	12.94	272	29411	276526	63182813
Hand deformity	58.93	12.94	4	29679	159453	63299886
Post cholecystectomy syndrome	58.30	12.94	17	29666	422	63458917
Toxicity to various agents	57.25	12.94	22	29661	247228	63212111
Pemphigus	56.69	12.94	9	29674	183717	63275622
Blood immunoglobulin A increased	56.53	12.94	19	29664	759	63458580
Hernia	54.54	12.94	46	29637	12528	63446811
Demyelination	53.99	12.94	36	29647	6884	63452455
Abdominal pain upper	53.95	12.94	215	29468	206229	63253110
Diarrhoea	52.90	12.94	538	29145	714828	62744511
Glossodynia	52.48	12.94	10	29673	178866	63280473
Drug interaction	52.03	12.94	21	29662	229110	63230229
Procedural pain	51.85	12.94	57	29626	21512	63437827
Systemic lupus erythematosus	51.06	12.94	17	29666	208901	63250438
Granulocyte count increased	50.27	12.94	18	29665	870	63458469
Glomerular filtration rate increased	50.07	12.94	18	29665	880	63458459
Aspartate aminotransferase	49.65	12.94	15	29668	422	63458917
Vitamin B12 increased	49.64	12.94	19	29664	1109	63458230
Presbyacusis	49.51	12.94	25	29658	2840	63456499
Glaucoma	49.02	12.94	52	29631	18853	63440486
General physical health deterioration	48.16	12.94	17	29666	201385	63257954
Pleural thickening	46.47	12.94	24	29659	2859	63456480
Maternal exposure during pregnancy	45.54	12.94	23	29660	220039	63239300
Incorrect route of product administration	45.40	12.94	60	29623	27392	63431947
Blood magnesium increased	45.28	12.94	24	29659	3014	63456325
Gastrooesophageal reflux disease	45.27	12.94	122	29561	95517	63363822
Pleural fibrosis	44.99	12.94	25	29658	3447	63455892
Sinusitis	44.00	12.94	216	29467	226437	63232902
Rheumatoid factor increased	43.70	12.94	20	29663	1829	63457510
Progressive multifocal leukoencephalopathy	43.44	12.94	41	29642	12930	63446409
Multiple sclerosis	43.01	12.94	55	29628	24317	63435022
Wound	40.39	12.94	13	29670	163250	63296089
Dry eye	40.18	12.94	70	29613	40691	63418648
Deafness neurosensory	39.68	12.94	26	29657	4829	63454510
Coordination abnormal	39.52	12.94	40	29643	13733	63445606
Urticaria	38.06	12.94	166	29517	165636	63293703
Eye disorder	36.62	12.94	49	29634	22636	63436703
Asthenia	36.57	12.94	305	29378	383299	63076040
Exposure during pregnancy	35.72	12.94	14	29669	155533	63303806
Blood immunoglobulin M increased	35.56	12.94	15	29668	1128	63458211
Rheumatic disorder	34.12	12.94	20	29663	3052	63456287
Multiple allergies	34.09	12.94	37	29646	13765	63445574
Epigastric discomfort	34.02	12.94	27	29656	6753	63452586
Blood immunoglobulin A decreased	33.51	12.94	15	29668	1302	63458037
Cataract operation	32.10	12.94	24	29659	5498	63453841
Completed suicide	32.01	12.94	14	29669	145659	63313680
Bone cyst	31.33	12.94	17	29666	2237	63457102
Hepatic enzyme abnormal	31.10	12.94	25	29658	6367	63452972
Throat clearing	30.21	12.94	17	29666	2402	63456937
Duodenal ulcer perforation	29.97	12.94	3	29680	87206	63372133
Pericarditis	29.95	12.94	12	29671	131567	63327772
Joint noise	29.89	12.94	21	29662	4371	63454968
Infective pulmonary exacerbation of cystic fibrosis	29.78	12.94	28	29655	8789	63450550
Anti-cyclic citrullinated peptide antibody positive	29.19	12.94	9	29674	116203	63343136
Dactylitis	28.99	12.94	17	29666	2595	63456744
Urine leukocyte esterase positive	28.84	12.94	19	29664	3560	63455779
Rheumatoid factor positive	28.76	12.94	3	29680	84403	63374936
Acute kidney injury	28.17	12.94	50	29633	263365	63195974
Blood immunoglobulin G increased	27.48	12.94	16	29667	2411	63456928
Depressed mood	27.33	12.94	59	29624	40132	63419207
Cataract	27.20	12.94	73	29610	56980	63402359
Dyspepsia	27.11	12.94	107	29576	102089	63357250
Balance disorder	27.09	12.94	94	29589	84328	63375011
Spinal disorder	27.03	12.94	28	29655	9874	63449465
Headache	26.85	12.94	430	29253	632811	62826528
Cyst	26.76	12.94	33	29650	14066	63445273
Discomfort	25.94	12.94	24	29659	167350	63291989
Underdose	25.57	12.94	46	29637	27410	63431929
Product dose omission issue	25.40	12.94	192	29491	234121	63225218
Osteosclerosis	25.09	12.94	18	29665	3870	63455469
Adrenal insufficiency	24.88	12.94	36	29647	17879	63441460
White blood cell count decreased	24.45	12.94	129	29554	138975	63320364
Intentional overdose	24.34	12.94	3	29680	74149	63385190
Blood uric acid increased	24.03	12.94	20	29663	5347	63453992
Neuropathy peripheral	23.96	12.94	111	29572	113556	63345783
Low turnover osteopathy	23.91	12.94	18	29665	4167	63455172
Fatigue	23.72	12.94	562	29121	887466	62571873
Cardiac arrest	23.54	12.94	7	29676	92538	63366801
Pain in extremity	23.25	12.94	247	29436	331239	63128100
Vaginal flatulence	23	12.94	16	29667	3277	63456062
Coma	22.71	12.94	74	29609	64290	63395049
Herpes zoster	22.40	12.94	87	29596	82375	63376964
Febrile neutropenia	22.16	12.94	14	29669	118435	63340904
Throat irritation	21.95	12.94	52	29631	37595	63421744
Osteopenia	20.84	12.94	35	29648	19750	63439589
Blood pressure increased	20.58	12.94	138	29545	161924	63297415
Red blood cell count decreased	20.39	12.94	53	29630	40592	63418747
Blood pressure systolic decreased	20.34	12.94	21	29662	7376	63451963
Pancytopenia	20.23	12.94	10	29673	96923	63362416
Vitamin B12 deficiency	20.17	12.94	18	29665	5285	63454054
Constipation	19.88	12.94	176	29507	224767	63234572
Blood test abnormal	19.69	12.94	30	29653	15599	63443740
Pruritus	19.45	12.94	256	29427	361197	63098142
Ulcer	18.52	12.94	39	29644	26068	63433271
Somnolence	18.01	12.94	144	29539	178541	63280798
Vitamin D deficiency	17.97	12.94	27	29656	13865	63445474
Proctitis	17.84	12.94	17	29666	5424	63453915
Abdominal discomfort	17.38	12.94	84	29599	320801	63138538
Overdose	17.24	12.94	17	29666	115061	63344278
Spinal epidural haematoma	17.07	12.94	9	29674	1118	63458221
Synovitis	16.96	12.94	39	29644	186879	63272460
Monocyte count increased	16.63	12.94	19	29664	7474	63451865
Depression	16.47	12.94	152	29531	196340	63262999
Death	16.46	12.94	105	29578	374276	63085063
Bradycardia	16.14	12.94	7	29676	73220	63386119
Helicobacter infection	15.98	12.94	12	29671	92773	63366566
Skin reaction	15.28	12.94	26	29657	14823	63444516
Septic shock	15.28	12.94	6	29677	66623	63392716
Interstitial lung disease	15.17	12.94	5	29678	61903	63397436
Cholecystitis acute	15.14	12.94	19	29664	8241	63451098
Swelling	14.96	12.94	72	29611	275306	63184033
Colitis microscopic	14.81	12.94	20	29663	9319	63450020
Suicide attempt	14.79	12.94	5	29678	60913	63398426
Bone hypertrophy	14.66	12.94	6	29677	418	63458921
Confusional state	14.53	12.94	59	29624	236321	63223018
Dry mouth	14.22	12.94	73	29610	77790	63381549
Bronchitis	13.87	12.94	103	29580	124832	63334507
Pleural effusion	13.70	12.94	14	29669	93196	63366143
Malignant neoplasm progression	13.66	12.94	11	29672	82110	63377229
Body height decreased	13.63	12.94	20	29663	10058	63449281
Miosis	13.61	12.94	17	29666	7336	63452003
Cardiac failure	13.55	12.94	13	29670	89129	63370210
Vaginal discharge	13.53	12.94	19	29664	9179	63450160
Pulmonary embolism	13.52	12.94	21	29662	116663	63342676
Diverticulitis	13.52	12.94	45	29638	39512	63419827
Skin lesion	13.34	12.94	38	29645	30683	63428656
Increased bronchial secretion	13.33	12.94	9	29674	1757	63457582
Joint swelling	13.26	12.94	221	29462	327445	63131894
Female genital tract fistula	13.24	12.94	17	29666	7542	63451797
Neutropenia	13.22	12.94	40	29643	174965	63284374
Multiple organ dysfunction syndrome	13.20	12.94	5	29678	56747	63402592
Mucosal inflammation	12.98	12.94	3	29680	46925	63412414

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood phosphorus increased	160.06	17.44	67	10566	7654	34938644
Appendicolith	159.62	17.44	69	10564	8532	34937766
Appendicitis	126.76	17.44	70	10563	14737	34931561
Ventricular fibrillation	100.85	17.44	71	10562	22883	34923415
Fractional exhaled nitric oxide increased	96.78	17.44	28	10605	1054	34945244
Stress	93.66	17.44	76	10557	30271	34916027
Cardiogenic shock	89.27	17.44	70	10563	26548	34919750
Dry mouth	83.63	17.44	71	10562	30094	34916204
Infective pulmonary exacerbation of cystic fibrosis	74.74	17.44	38	10595	6763	34939535
Plantar fasciitis	74.56	17.44	27	10606	2089	34944209
Sensation of foreign body	70.85	17.44	28	10605	2755	34943543
Abdominal distension	70.70	17.44	88	10545	58404	34887894
Myoglobin blood increased	68.61	17.44	28	10605	2995	34943303
Ascites	66.02	17.44	76	10557	46495	34899803
Secretion discharge	64.90	17.44	33	10600	5872	34940426
Myasthenia gravis	62.65	17.44	34	10599	6906	34939392
Blood uric acid increased	59.84	17.44	37	10596	9587	34936711
Blood cholesterol increased	58.25	17.44	49	10584	20494	34925804
Constipation	56.55	17.44	127	10506	136855	34809443
Brain natriuretic peptide increased	54.66	17.44	29	10604	5630	34940668
Therapy cessation	47.12	17.44	40	10593	16933	34929365
Nasopharyngitis	43.45	17.44	77	10556	69891	34876407
Chest discomfort	39.11	17.44	64	10569	54466	34891832
Hyponatraemia	37.86	17.44	80	10553	82611	34863687
Analgesic therapy	36.15	17.44	13	10620	985	34945313
Muscle spasms	36.01	17.44	74	10559	74927	34871371
Sleep disorder therapy	35.84	17.44	13	10620	1010	34945288
Multiple organ dysfunction syndrome	34.96	17.44	74	10559	76492	34869806
Drug therapy	34.46	17.44	13	10620	1128	34945170
Obstructive airways disorder	34.04	17.44	32	10601	15462	34930836
Dysphonia	31.17	17.44	37	10596	23346	34922952
Cardiac disorder	30.09	17.44	50	10583	43076	34903222
Toxicity to various agents	29.56	17.44	12	10621	200350	34745948
Exostosis	28.96	17.44	18	10615	4705	34941593
Somnolence	28.25	17.44	86	10547	111030	34835268
Abdominal pain	27.99	17.44	111	10522	163507	34782791
Drug interaction	26.73	17.44	18	10615	225928	34720370
Rubber sensitivity	25.25	17.44	7	10626	225	34946073
Nausea	25.18	17.44	183	10450	339725	34606573
Hyperphosphataemia	24.92	17.44	16	10617	4421	34941877
Iron deficiency	24.44	17.44	17	10616	5364	34940934
Drug intolerance	24.25	17.44	55	10578	59515	34886783
Wheezing	22.44	17.44	43	10590	41359	34904939
Incorrect route of product administration	22.32	17.44	25	10608	14820	34931478
Neuralgia	21.95	17.44	25	10608	15088	34931210
Product dose omission issue	21.08	17.44	82	10551	119629	34826669
Hypophosphataemia	20.89	17.44	21	10612	11005	34935293
Dyspnoea exertional	19.93	17.44	42	10591	43237	34903061
Acute kidney injury	19.25	17.44	40	10593	304948	34641350
Forced expiratory volume decreased	19.11	17.44	12	10621	3191	34943107
Completed suicide	17.85	17.44	4	10629	98164	34848134

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	166.66	13.35	106	32602	21369	79690311
Therapy cessation	137.80	13.35	118	32590	37444	79674236
Appendicolith	137.17	13.35	68	32640	8483	79703197
Blood phosphorus increased	122.17	13.35	67	32641	10280	79701400
Electric shock	113.72	13.35	36	32672	1358	79710322
Ear pain	108.01	13.35	97	32611	32772	79678908
Macular degeneration	93.25	13.35	58	32650	11238	79700442
Toxicity to various agents	92.44	13.35	29	32679	421511	79290169
Respiratory disorder	91.20	13.35	102	32606	44754	79666926
Peripheral swelling	88.36	13.35	277	32431	269340	79442340
Drug interaction	86.78	13.35	31	32677	415152	79296528
Body temperature increased	85.20	13.35	98	32610	44322	79667358
Night sweats	83.65	13.35	105	32603	51990	79659690
Chronic sinusitis	83.32	13.35	57	32651	12969	79698711
Blood uric acid increased	82.01	13.35	57	32651	13303	79698377
Appendicitis	81.75	13.35	68	32640	20726	79690954
Infective pulmonary exacerbation of cystic fibrosis	81.65	13.35	56	32652	12795	79698885
Post-traumatic stress disorder	78.83	13.35	39	32669	4842	79706838
Intervertebral discitis	76.27	13.35	38	32670	4790	79706890
Incorrect route of product administration	73.71	13.35	81	32627	34848	79676832
Back pain	69.06	13.35	277	32431	303903	79407777
Dry mouth	68.97	13.35	127	32581	87892	79623788
Insomnia	64.46	13.35	234	32474	244936	79466744
Temperature intolerance	63.33	13.35	43	32665	9662	79702018
Post cholecystectomy syndrome	62.40	13.35	17	32691	375	79711305
Ventricular fibrillation	60.48	13.35	70	32638	31856	79679824
Abdominal pain upper	59.15	13.35	214	32494	223605	79488075
Paraesthesia oral	58.69	13.35	56	32652	20415	79691265
Acute kidney injury	57.96	13.35	77	32631	519327	79192353
Sinusitis	54.28	13.35	190	32518	195311	79516369
Dry eye	53.88	13.35	71	32637	36860	79674820
Completed suicide	53.65	13.35	17	32691	245750	79465930
Demyelination	53.43	13.35	36	32672	7987	79703693
Procedural pain	53.04	13.35	56	32652	23028	79688652
Stress	52.73	13.35	107	32601	79505	79632175
Weight decreased	51.55	13.35	284	32424	354914	79356766
Presbyacusis	51.28	13.35	24	32684	2636	79709044
Vitamin B12 increased	50.71	13.35	19	32689	1194	79710486
Aspartate aminotransferase	47.33	13.35	15	32693	568	79711112
Myasthenia gravis	47.22	13.35	37	32671	10362	79701318
Glomerular filtration rate increased	47.12	13.35	18	32690	1193	79710487
Blood immunoglobulin A increased	47.01	13.35	17	32691	966	79710714
Rheumatoid factor increased	46.50	13.35	20	32688	1801	79709879
Granulocyte count increased	46.09	13.35	18	32690	1267	79710413
Hernia	45.77	13.35	45	32663	17014	79694666
Pleural thickening	45.72	13.35	23	32685	2959	79708721
Glaucoma	45.51	13.35	48	32660	19713	79691967
Blood magnesium increased	45.00	13.35	24	32684	3482	79708198
Constipation	44.23	13.35	231	32477	282819	79428861
Multiple sclerosis	44.14	13.35	50	32658	22232	79689448
Cardiogenic shock	44.12	13.35	69	32639	41845	79669835
Abdominal distension	42.92	13.35	127	32581	119523	79592157
Diarrhoea	41.78	13.35	547	32161	879942	78831738
Pleural fibrosis	41.13	13.35	24	32684	4143	79707537
Urticaria	40.65	13.35	167	32541	185034	79526646
Gastrooesophageal reflux disease	40.63	13.35	114	32594	104132	79607548
Eye disorder	38.87	13.35	48	32660	23364	79688316
Progressive multifocal leukoencephalopathy	37.07	13.35	44	32664	20556	79691124
Somnolence	36.60	13.35	194	32514	238787	79472893
Pain	36.20	13.35	444	32264	703358	79008322
Blood cholesterol increased	36.07	13.35	95	32613	83625	79628055
Rheumatic disorder	36.04	13.35	20	32688	3138	79708542
Nausea	35.61	13.35	570	32138	956626	78755054
Fatigue	35.09	13.35	555	32153	929172	78782508
Blood immunoglobulin M increased	34.87	13.35	15	32693	1351	79710329
Deafness neurosensory	34.51	13.35	26	32682	6872	79704808
Blood immunoglobulin A decreased	33.98	13.35	15	32693	1438	79710242
Febrile neutropenia	33.92	13.35	27	32681	230972	79480708
Cataract operation	33.90	13.35	23	32685	5162	79706518
Multiple allergies	32.65	13.35	30	32678	10430	79701250
Intentional overdose	32.47	13.35	3	32705	105957	79605723
Interstitial lung disease	32.43	13.35	4	32704	112596	79599084
Cardiac arrest	32.40	13.35	15	32693	172081	79539599
Analgesic therapy	32.23	13.35	13	32695	996	79710684
Sleep disorder therapy	32.04	13.35	13	32695	1011	79710669
Hepatic enzyme abnormal	31.65	13.35	26	32682	7784	79703896
Epigastric discomfort	31.40	13.35	26	32682	7870	79703810
Coordination abnormal	31.19	13.35	37	32671	17275	79694405
Headache	30.85	13.35	406	32302	653366	79058314
Throat clearing	30.81	13.35	17	32691	2637	79709043
Bradycardia	30.25	13.35	9	32699	135548	79576132
Dactylitis	30.21	13.35	17	32691	2740	79708940
Drug therapy	30.04	13.35	13	32695	1188	79710492
Depressed mood	29.56	13.35	63	32645	48417	79663263
Product dose omission issue	29.47	13.35	188	32520	247349	79464331
Joint swelling	29.45	13.35	211	32497	288435	79423245
Joint noise	29.30	13.35	19	32689	3955	79707725
Hand deformity	29.18	13.35	4	32704	103915	79607765
Ascites	28.82	13.35	82	32626	75480	79636200
Urine leukocyte esterase positive	28.79	13.35	19	32689	4072	79707608
Neutropenia	28.75	13.35	46	32662	287664	79424016
Cardio-respiratory arrest	28.60	13.35	5	32703	108505	79603175
Vaginal flatulence	28.55	13.35	16	32692	2559	79709121
Dyspepsia	27.89	13.35	103	32605	108584	79603096
Cataract	27.27	13.35	71	32637	62049	79649631
Throat irritation	27.06	13.35	55	32653	40891	79670789
Osteosclerosis	26.88	13.35	18	32690	3953	79707727
Bone cyst	26.76	13.35	17	32691	3416	79708264
Pain in extremity	26.65	13.35	247	32461	364291	79347389
Blood immunoglobulin G increased	26.33	13.35	16	32692	2973	79708707
Osteopenia	26.31	13.35	35	32673	18329	79693351
Pneumonia aspiration	25.85	13.35	73	32635	66894	79644786
Overdose	25.24	13.35	23	32685	184183	79527497
Pancytopenia	24.80	13.35	19	32689	165726	79545954
Cardiac failure	24.14	13.35	17	32691	154825	79556855
Maternal exposure during pregnancy	24.05	13.35	13	32695	136525	79575155
Cyst	23.98	13.35	29	32679	13811	79697869
Metabolic acidosis	23.60	13.35	3	32705	82526	79629154
Proctitis	23.16	13.35	20	32688	6412	79705268
Blood test abnormal	22.72	13.35	32	32676	17678	79694002
Septic shock	22.66	13.35	11	32697	122790	79588890
Underdose	22.47	13.35	45	32663	33106	79678574
Malignant neoplasm progression	22.45	13.35	14	32694	135976	79575704
Asthenia	21.34	13.35	311	32397	511378	79200302
Blood pressure increased	21.25	13.35	154	32554	211206	79500474
Spinal disorder	20.28	13.35	23	32685	10237	79701443
Sleep disorder	20.17	13.35	79	32629	85598	79626082
Thrombocytopenia	19.98	13.35	50	32658	265209	79446471
Arthralgia	19.85	13.35	337	32371	571466	79140214
Neuropathy peripheral	19.79	13.35	112	32596	141193	79570487
Herpes zoster	19.66	13.35	83	32625	93000	79618680
Ulcer	19.50	13.35	40	32668	29932	79681748
Suicide attempt	19.44	13.35	5	32703	82927	79628753
Bronchitis	19.26	13.35	105	32603	130539	79581141
Hypotension	18.74	13.35	105	32603	440212	79271468
Female genital tract fistula	18.38	13.35	17	32691	5958	79705722
Pemphigus	18.25	13.35	9	32699	99573	79612107
Pruritus	18.11	13.35	244	32464	394404	79317276
Deformity	18.09	13.35	21	32687	9584	79702096
Flatulence	17.91	13.35	48	32660	42676	79669004
Rhabdomyolysis	17.89	13.35	10	32698	103121	79608559
Balance disorder	17.76	13.35	84	32624	98773	79612907
Duodenal ulcer perforation	17.56	13.35	3	32705	66208	79645472
Hyperphosphataemia	17.44	13.35	17	32691	6359	79705321
Exposure during pregnancy	17.27	13.35	10	32698	101122	79610558
Hyperkalaemia	17.25	13.35	13	32695	114385	79597295
White blood cell count decreased	17.12	13.35	134	32574	188154	79523526
Rubber sensitivity	17.07	13.35	10	32698	1739	79709941
Vaginal discharge	16.95	13.35	18	32690	7445	79704235
Systemic lupus erythematosus	16.74	13.35	15	32693	121134	79590546
Alanine aminotransferase increased	16.65	13.35	119	32589	162451	79549229
Glossodynia	16.56	13.35	11	32697	103326	79608354
Nasopharyngitis	16.55	13.35	168	32540	253713	79457967
Lower respiratory tract infection	16.52	13.35	100	32608	129120	79582560
Iron deficiency	16.34	13.35	21	32687	10633	79701047
Adrenal insufficiency	16.20	13.35	36	32672	28451	79683229
Radiculopathy	16.13	13.35	19	32689	8805	79702875
Multiple fractures	15.88	13.35	18	32690	8008	79703672
Diverticulitis	15.74	13.35	48	32660	45888	79665792
Confusional state	15.70	13.35	72	32636	317925	79393755
Vitamin B12 deficiency	15.63	13.35	17	32691	7224	79704456
Skin lesion	15.55	13.35	45	32663	41799	79669881
Skin irritation	15.46	13.35	21	32687	11219	79700461
Hypokalaemia	15.37	13.35	22	32686	144018	79567662
Rheumatoid factor positive	15.25	13.35	3	32705	59836	79651844
Mucosal inflammation	15.16	13.35	6	32702	75574	79636106
Skin reaction	14.93	13.35	25	32683	16043	79695637
Drug reaction with eosinophilia and systemic symptoms	14.82	13.35	4	32704	64240	79647440
Monocyte count increased	14.78	13.35	20	32688	10641	79701039
Colitis microscopic	14.63	13.35	20	32688	10748	79700932
Sciatica	14.61	13.35	38	32670	33184	79678496
Depressed level of consciousness	14.55	13.35	11	32697	96641	79615039
Respiratory arrest	14.42	13.35	3	32705	57547	79654133
Blood pressure systolic decreased	14.19	13.35	20	32688	11056	79700624
Angioedema	13.74	13.35	7	32701	76028	79635652
Respiratory failure	13.69	13.35	34	32674	180877	79530803
Blood creatine phosphokinase increased	13.66	13.35	5	32703	66085	79645595
Bone hypertrophy	13.63	13.35	6	32702	571	79711109
Spinal epidural haematoma	13.48	13.35	8	32700	1424	79710256

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA08	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:22587	antiviral agents
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:37700	protein kinase C inhibitors
CHEBI has role	CHEBI:50249	anticoagulants
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:50846	Immunologic factor
CHEBI has role	CHEBI:50855	antiatherogenic drug
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:84735	algal metabolites
MeSH PA	D000975	Antioxidants
MeSH PA	D018977	Micronutrients
MeSH PA	D020011	Protective Agents
MeSH PA	D014815	Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Obstruction of bile duct	indication	30144000
Vitamin E deficiency	indication	54137008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.06	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glutathione S-transferase P	Enzyme	P09211	GSTP1_HUMAN		IC50	6.30		CHEMBL
Alpha-tocopherol transfer protein	Transporter	P49638	TTPA_HUMAN		Kd	5.62		CHEMBL

External reference:

ID	Source
N0000011305	NUI
10191-41-0	SECONDARY_CAS_RN
4017771	VANDF
CHEBI:18145	CHEBI
VIV	PDB_CHEM_ID
CHEMBL2108106	ChEMBL_ID
D06174	KEGG_DRUG
CHEMBL3989727	ChEMBL_ID
CHEMBL47	ChEMBL_ID
C014225	MESH_SUPPLEMENTAL_RECORD_UI
DB11635	DRUGBANK_ID
DB00163	DRUGBANK_ID
159151	RXNORM
11960	MMSL
40928	MMSL
001020	NDDF
009945	NDDF
116776001	SNOMEDCT_US
259666007	SNOMEDCT_US
768524003	SNOMEDCT_US
C0606070	UMLSCUI
D024502	MESH_DESCRIPTOR_UI
71406	PUBCHEM_CID
N9PR3490H9	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	30 [iU]	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	30 [iU]	ORAL	unapproved drug other	10 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0798	CAPSULE, GELATIN COATED	30 [iU]	ORAL	UNAPPROVED DRUG OTHER	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0799	CAPSULE, GELATIN COATED	30 [iU]	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0812	CAPSULE, GELATIN COATED	30 [iU]	ORAL	Unapproved drug other	11 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	15 [iU]	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	15 [iU]	ORAL	unapproved drug other	10 sections
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	9 mg	ORAL	unapproved drug other	14 sections
Vitafol Caplet	HUMAN PRESCRIPTION DRUG LABEL	12	0642-0072	CAPSULE	10 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	30 [iU]	ORAL	Unapproved drug other	14 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	30 [iU]	ORAL	Unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	10 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	60 [iU]	ORAL	UNAPPROVED DRUG OTHER	15 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	20 [iU]	ORAL	unapproved drug other	7 sections
Quflora Pediatric	HUMAN PRESCRIPTION DRUG LABEL	14	15370-103	TABLET, CHEWABLE	15 [iU]	ORAL	UNAPPROVED DRUG OTHER	12 sections
Quflora Pediatric	HUMAN PRESCRIPTION DRUG LABEL	14	15370-104	TABLET, CHEWABLE	15 [iU]	ORAL	UNAPPROVED DRUG OTHER	12 sections
Quflora Pediatric	HUMAN PRESCRIPTION DRUG LABEL	14	15370-105	TABLET, CHEWABLE	15 [iU]	ORAL	UNAPPROVED DRUG OTHER	12 sections
C-Nate DHA	HUMAN PRESCRIPTION DRUG LABEL	13	23359-105	CAPSULE, GELATIN COATED	30 [iU]	ORAL	unapproved drug other	15 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	10 [iU]	ORAL	unapproved drug other	12 sections
Prenaissance	HUMAN PRESCRIPTION DRUG LABEL	9	42192-341	CAPSULE, LIQUID FILLED	30 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
Poly-ViFlor	HUMAN PRESCRIPTION DRUG LABEL	11	42494-432	TABLET, CHEWABLE	10 mg	ORAL	Unapproved drug other	6 sections
Poly-ViFlor	HUMAN PRESCRIPTION DRUG LABEL	11	42494-433	TABLET, CHEWABLE	10 mg	ORAL	Unapproved drug other	6 sections
Poly-ViFlor	HUMAN PRESCRIPTION DRUG LABEL	11	42494-434	TABLET, CHEWABLE	10 mg	ORAL	Unapproved drug other	6 sections
Kimchi Vitaminchewable multivitamin	HUMAN OTC DRUG LABEL	11	52102-1001	TABLET, CHEWABLE	1.88 mg	ORAL	unapproved drug other	4 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	20 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	20 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	20 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections
Vitalipid N	HUMAN PRESCRIPTION DRUG LABEL	4	65219-335	EMULSION	1 [iU]	INTRAVENOUS	Unapproved drug for use in drug shortage	4 sections
Vitalipid N	HUMAN PRESCRIPTION DRUG LABEL	4	65219-337	EMULSION	0.70 [iU]	INTRAVENOUS	Unapproved drug for use in drug shortage	4 sections
Vitalipid N	HUMAN PRESCRIPTION DRUG LABEL	4	65219-339	EMULSION	0.70 [iU]	INTRAVENOUS	Unapproved drug for use in drug shortage	4 sections