tocofersolan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4280 59-02-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tocophersolan
  • .ALPHA.-TOCOPHEROL, D-
  • alpha-tocopherol
  • alpha-D-Tocopherol
  • syntopherol
  • ALPHA-TOCOPHEROL, D-
  • .ALPHA.-TOCOPHEROL
  • d-alpha-tocopherol
  • alpha-tocopherol, dl-
  • .Alpha.-tocopherol, DL-
  • tocofersolan
  • vedrop
A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.
  • Molecular weight: 430.72
  • Formula: C29H50O2
  • CLOGP: 12
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -7.79
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 274.47 12.94 160 29523 24216 63435123
Muscle spasticity 162.06 12.94 110 29573 21684 63437655
Electric shock 111.02 12.94 36 29647 1284 63458055
Therapy cessation 107.33 12.94 99 29584 30358 63428981
Ear pain 103.90 12.94 105 29578 36013 63423326
Body temperature increased 97.74 12.94 103 29580 37089 63422250
Night sweats 85.95 12.94 110 29573 48704 63410635
Respiratory disorder 83.30 12.94 97 29586 38985 63420354
Chronic sinusitis 81.87 12.94 59 29624 12784 63446555
Back pain 79.82 12.94 288 29395 263857 63195482
Intervertebral discitis 79.72 12.94 36 29647 3192 63456147
Peripheral swelling 76.18 12.94 285 29398 265657 63193682
Post-traumatic stress disorder 71.33 12.94 39 29644 5212 63454127
Insomnia 64.39 12.94 234 29449 215018 63244321
Paraesthesia oral 62.86 12.94 60 29623 19196 63440143
Pneumonia aspiration 62.64 12.94 79 29604 34461 63424878
Temperature intolerance 61.33 12.94 43 29640 8921 63450418
Weight decreased 59.80 12.94 272 29411 276526 63182813
Hand deformity 58.93 12.94 4 29679 159453 63299886
Post cholecystectomy syndrome 58.30 12.94 17 29666 422 63458917
Toxicity to various agents 57.25 12.94 22 29661 247228 63212111
Pemphigus 56.69 12.94 9 29674 183717 63275622
Blood immunoglobulin A increased 56.53 12.94 19 29664 759 63458580
Hernia 54.54 12.94 46 29637 12528 63446811
Demyelination 53.99 12.94 36 29647 6884 63452455
Abdominal pain upper 53.95 12.94 215 29468 206229 63253110
Diarrhoea 52.90 12.94 538 29145 714828 62744511
Glossodynia 52.48 12.94 10 29673 178866 63280473
Drug interaction 52.03 12.94 21 29662 229110 63230229
Procedural pain 51.85 12.94 57 29626 21512 63437827
Systemic lupus erythematosus 51.06 12.94 17 29666 208901 63250438
Granulocyte count increased 50.27 12.94 18 29665 870 63458469
Glomerular filtration rate increased 50.07 12.94 18 29665 880 63458459
Aspartate aminotransferase 49.65 12.94 15 29668 422 63458917
Vitamin B12 increased 49.64 12.94 19 29664 1109 63458230
Presbyacusis 49.51 12.94 25 29658 2840 63456499
Glaucoma 49.02 12.94 52 29631 18853 63440486
General physical health deterioration 48.16 12.94 17 29666 201385 63257954
Pleural thickening 46.47 12.94 24 29659 2859 63456480
Maternal exposure during pregnancy 45.54 12.94 23 29660 220039 63239300
Incorrect route of product administration 45.40 12.94 60 29623 27392 63431947
Blood magnesium increased 45.28 12.94 24 29659 3014 63456325
Gastrooesophageal reflux disease 45.27 12.94 122 29561 95517 63363822
Pleural fibrosis 44.99 12.94 25 29658 3447 63455892
Sinusitis 44.00 12.94 216 29467 226437 63232902
Rheumatoid factor increased 43.70 12.94 20 29663 1829 63457510
Progressive multifocal leukoencephalopathy 43.44 12.94 41 29642 12930 63446409
Multiple sclerosis 43.01 12.94 55 29628 24317 63435022
Wound 40.39 12.94 13 29670 163250 63296089
Dry eye 40.18 12.94 70 29613 40691 63418648
Deafness neurosensory 39.68 12.94 26 29657 4829 63454510
Coordination abnormal 39.52 12.94 40 29643 13733 63445606
Urticaria 38.06 12.94 166 29517 165636 63293703
Eye disorder 36.62 12.94 49 29634 22636 63436703
Asthenia 36.57 12.94 305 29378 383299 63076040
Exposure during pregnancy 35.72 12.94 14 29669 155533 63303806
Blood immunoglobulin M increased 35.56 12.94 15 29668 1128 63458211
Rheumatic disorder 34.12 12.94 20 29663 3052 63456287
Multiple allergies 34.09 12.94 37 29646 13765 63445574
Epigastric discomfort 34.02 12.94 27 29656 6753 63452586
Blood immunoglobulin A decreased 33.51 12.94 15 29668 1302 63458037
Cataract operation 32.10 12.94 24 29659 5498 63453841
Completed suicide 32.01 12.94 14 29669 145659 63313680
Bone cyst 31.33 12.94 17 29666 2237 63457102
Hepatic enzyme abnormal 31.10 12.94 25 29658 6367 63452972
Throat clearing 30.21 12.94 17 29666 2402 63456937
Duodenal ulcer perforation 29.97 12.94 3 29680 87206 63372133
Pericarditis 29.95 12.94 12 29671 131567 63327772
Joint noise 29.89 12.94 21 29662 4371 63454968
Infective pulmonary exacerbation of cystic fibrosis 29.78 12.94 28 29655 8789 63450550
Anti-cyclic citrullinated peptide antibody positive 29.19 12.94 9 29674 116203 63343136
Dactylitis 28.99 12.94 17 29666 2595 63456744
Urine leukocyte esterase positive 28.84 12.94 19 29664 3560 63455779
Rheumatoid factor positive 28.76 12.94 3 29680 84403 63374936
Acute kidney injury 28.17 12.94 50 29633 263365 63195974
Blood immunoglobulin G increased 27.48 12.94 16 29667 2411 63456928
Depressed mood 27.33 12.94 59 29624 40132 63419207
Cataract 27.20 12.94 73 29610 56980 63402359
Dyspepsia 27.11 12.94 107 29576 102089 63357250
Balance disorder 27.09 12.94 94 29589 84328 63375011
Spinal disorder 27.03 12.94 28 29655 9874 63449465
Headache 26.85 12.94 430 29253 632811 62826528
Cyst 26.76 12.94 33 29650 14066 63445273
Discomfort 25.94 12.94 24 29659 167350 63291989
Underdose 25.57 12.94 46 29637 27410 63431929
Product dose omission issue 25.40 12.94 192 29491 234121 63225218
Osteosclerosis 25.09 12.94 18 29665 3870 63455469
Adrenal insufficiency 24.88 12.94 36 29647 17879 63441460
White blood cell count decreased 24.45 12.94 129 29554 138975 63320364
Intentional overdose 24.34 12.94 3 29680 74149 63385190
Blood uric acid increased 24.03 12.94 20 29663 5347 63453992
Neuropathy peripheral 23.96 12.94 111 29572 113556 63345783
Low turnover osteopathy 23.91 12.94 18 29665 4167 63455172
Fatigue 23.72 12.94 562 29121 887466 62571873
Cardiac arrest 23.54 12.94 7 29676 92538 63366801
Pain in extremity 23.25 12.94 247 29436 331239 63128100
Vaginal flatulence 23 12.94 16 29667 3277 63456062
Coma 22.71 12.94 74 29609 64290 63395049
Herpes zoster 22.40 12.94 87 29596 82375 63376964
Febrile neutropenia 22.16 12.94 14 29669 118435 63340904
Throat irritation 21.95 12.94 52 29631 37595 63421744
Osteopenia 20.84 12.94 35 29648 19750 63439589
Blood pressure increased 20.58 12.94 138 29545 161924 63297415
Red blood cell count decreased 20.39 12.94 53 29630 40592 63418747
Blood pressure systolic decreased 20.34 12.94 21 29662 7376 63451963
Pancytopenia 20.23 12.94 10 29673 96923 63362416
Vitamin B12 deficiency 20.17 12.94 18 29665 5285 63454054
Constipation 19.88 12.94 176 29507 224767 63234572
Blood test abnormal 19.69 12.94 30 29653 15599 63443740
Pruritus 19.45 12.94 256 29427 361197 63098142
Ulcer 18.52 12.94 39 29644 26068 63433271
Somnolence 18.01 12.94 144 29539 178541 63280798
Vitamin D deficiency 17.97 12.94 27 29656 13865 63445474
Proctitis 17.84 12.94 17 29666 5424 63453915
Abdominal discomfort 17.38 12.94 84 29599 320801 63138538
Overdose 17.24 12.94 17 29666 115061 63344278
Spinal epidural haematoma 17.07 12.94 9 29674 1118 63458221
Synovitis 16.96 12.94 39 29644 186879 63272460
Monocyte count increased 16.63 12.94 19 29664 7474 63451865
Depression 16.47 12.94 152 29531 196340 63262999
Death 16.46 12.94 105 29578 374276 63085063
Bradycardia 16.14 12.94 7 29676 73220 63386119
Helicobacter infection 15.98 12.94 12 29671 92773 63366566
Skin reaction 15.28 12.94 26 29657 14823 63444516
Septic shock 15.28 12.94 6 29677 66623 63392716
Interstitial lung disease 15.17 12.94 5 29678 61903 63397436
Cholecystitis acute 15.14 12.94 19 29664 8241 63451098
Swelling 14.96 12.94 72 29611 275306 63184033
Colitis microscopic 14.81 12.94 20 29663 9319 63450020
Suicide attempt 14.79 12.94 5 29678 60913 63398426
Bone hypertrophy 14.66 12.94 6 29677 418 63458921
Confusional state 14.53 12.94 59 29624 236321 63223018
Dry mouth 14.22 12.94 73 29610 77790 63381549
Bronchitis 13.87 12.94 103 29580 124832 63334507
Pleural effusion 13.70 12.94 14 29669 93196 63366143
Malignant neoplasm progression 13.66 12.94 11 29672 82110 63377229
Body height decreased 13.63 12.94 20 29663 10058 63449281
Miosis 13.61 12.94 17 29666 7336 63452003
Cardiac failure 13.55 12.94 13 29670 89129 63370210
Vaginal discharge 13.53 12.94 19 29664 9179 63450160
Pulmonary embolism 13.52 12.94 21 29662 116663 63342676
Diverticulitis 13.52 12.94 45 29638 39512 63419827
Skin lesion 13.34 12.94 38 29645 30683 63428656
Increased bronchial secretion 13.33 12.94 9 29674 1757 63457582
Joint swelling 13.26 12.94 221 29462 327445 63131894
Female genital tract fistula 13.24 12.94 17 29666 7542 63451797
Neutropenia 13.22 12.94 40 29643 174965 63284374
Multiple organ dysfunction syndrome 13.20 12.94 5 29678 56747 63402592
Mucosal inflammation 12.98 12.94 3 29680 46925 63412414

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 160.06 17.44 67 10566 7654 34938644
Appendicolith 159.62 17.44 69 10564 8532 34937766
Appendicitis 126.76 17.44 70 10563 14737 34931561
Ventricular fibrillation 100.85 17.44 71 10562 22883 34923415
Fractional exhaled nitric oxide increased 96.78 17.44 28 10605 1054 34945244
Stress 93.66 17.44 76 10557 30271 34916027
Cardiogenic shock 89.27 17.44 70 10563 26548 34919750
Dry mouth 83.63 17.44 71 10562 30094 34916204
Infective pulmonary exacerbation of cystic fibrosis 74.74 17.44 38 10595 6763 34939535
Plantar fasciitis 74.56 17.44 27 10606 2089 34944209
Sensation of foreign body 70.85 17.44 28 10605 2755 34943543
Abdominal distension 70.70 17.44 88 10545 58404 34887894
Myoglobin blood increased 68.61 17.44 28 10605 2995 34943303
Ascites 66.02 17.44 76 10557 46495 34899803
Secretion discharge 64.90 17.44 33 10600 5872 34940426
Myasthenia gravis 62.65 17.44 34 10599 6906 34939392
Blood uric acid increased 59.84 17.44 37 10596 9587 34936711
Blood cholesterol increased 58.25 17.44 49 10584 20494 34925804
Constipation 56.55 17.44 127 10506 136855 34809443
Brain natriuretic peptide increased 54.66 17.44 29 10604 5630 34940668
Therapy cessation 47.12 17.44 40 10593 16933 34929365
Nasopharyngitis 43.45 17.44 77 10556 69891 34876407
Chest discomfort 39.11 17.44 64 10569 54466 34891832
Hyponatraemia 37.86 17.44 80 10553 82611 34863687
Analgesic therapy 36.15 17.44 13 10620 985 34945313
Muscle spasms 36.01 17.44 74 10559 74927 34871371
Sleep disorder therapy 35.84 17.44 13 10620 1010 34945288
Multiple organ dysfunction syndrome 34.96 17.44 74 10559 76492 34869806
Drug therapy 34.46 17.44 13 10620 1128 34945170
Obstructive airways disorder 34.04 17.44 32 10601 15462 34930836
Dysphonia 31.17 17.44 37 10596 23346 34922952
Cardiac disorder 30.09 17.44 50 10583 43076 34903222
Toxicity to various agents 29.56 17.44 12 10621 200350 34745948
Exostosis 28.96 17.44 18 10615 4705 34941593
Somnolence 28.25 17.44 86 10547 111030 34835268
Abdominal pain 27.99 17.44 111 10522 163507 34782791
Drug interaction 26.73 17.44 18 10615 225928 34720370
Rubber sensitivity 25.25 17.44 7 10626 225 34946073
Nausea 25.18 17.44 183 10450 339725 34606573
Hyperphosphataemia 24.92 17.44 16 10617 4421 34941877
Iron deficiency 24.44 17.44 17 10616 5364 34940934
Drug intolerance 24.25 17.44 55 10578 59515 34886783
Wheezing 22.44 17.44 43 10590 41359 34904939
Incorrect route of product administration 22.32 17.44 25 10608 14820 34931478
Neuralgia 21.95 17.44 25 10608 15088 34931210
Product dose omission issue 21.08 17.44 82 10551 119629 34826669
Hypophosphataemia 20.89 17.44 21 10612 11005 34935293
Dyspnoea exertional 19.93 17.44 42 10591 43237 34903061
Acute kidney injury 19.25 17.44 40 10593 304948 34641350
Forced expiratory volume decreased 19.11 17.44 12 10621 3191 34943107
Completed suicide 17.85 17.44 4 10629 98164 34848134

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 166.66 13.35 106 32602 21369 79690311
Therapy cessation 137.80 13.35 118 32590 37444 79674236
Appendicolith 137.17 13.35 68 32640 8483 79703197
Blood phosphorus increased 122.17 13.35 67 32641 10280 79701400
Electric shock 113.72 13.35 36 32672 1358 79710322
Ear pain 108.01 13.35 97 32611 32772 79678908
Macular degeneration 93.25 13.35 58 32650 11238 79700442
Toxicity to various agents 92.44 13.35 29 32679 421511 79290169
Respiratory disorder 91.20 13.35 102 32606 44754 79666926
Peripheral swelling 88.36 13.35 277 32431 269340 79442340
Drug interaction 86.78 13.35 31 32677 415152 79296528
Body temperature increased 85.20 13.35 98 32610 44322 79667358
Night sweats 83.65 13.35 105 32603 51990 79659690
Chronic sinusitis 83.32 13.35 57 32651 12969 79698711
Blood uric acid increased 82.01 13.35 57 32651 13303 79698377
Appendicitis 81.75 13.35 68 32640 20726 79690954
Infective pulmonary exacerbation of cystic fibrosis 81.65 13.35 56 32652 12795 79698885
Post-traumatic stress disorder 78.83 13.35 39 32669 4842 79706838
Intervertebral discitis 76.27 13.35 38 32670 4790 79706890
Incorrect route of product administration 73.71 13.35 81 32627 34848 79676832
Back pain 69.06 13.35 277 32431 303903 79407777
Dry mouth 68.97 13.35 127 32581 87892 79623788
Insomnia 64.46 13.35 234 32474 244936 79466744
Temperature intolerance 63.33 13.35 43 32665 9662 79702018
Post cholecystectomy syndrome 62.40 13.35 17 32691 375 79711305
Ventricular fibrillation 60.48 13.35 70 32638 31856 79679824
Abdominal pain upper 59.15 13.35 214 32494 223605 79488075
Paraesthesia oral 58.69 13.35 56 32652 20415 79691265
Acute kidney injury 57.96 13.35 77 32631 519327 79192353
Sinusitis 54.28 13.35 190 32518 195311 79516369
Dry eye 53.88 13.35 71 32637 36860 79674820
Completed suicide 53.65 13.35 17 32691 245750 79465930
Demyelination 53.43 13.35 36 32672 7987 79703693
Procedural pain 53.04 13.35 56 32652 23028 79688652
Stress 52.73 13.35 107 32601 79505 79632175
Weight decreased 51.55 13.35 284 32424 354914 79356766
Presbyacusis 51.28 13.35 24 32684 2636 79709044
Vitamin B12 increased 50.71 13.35 19 32689 1194 79710486
Aspartate aminotransferase 47.33 13.35 15 32693 568 79711112
Myasthenia gravis 47.22 13.35 37 32671 10362 79701318
Glomerular filtration rate increased 47.12 13.35 18 32690 1193 79710487
Blood immunoglobulin A increased 47.01 13.35 17 32691 966 79710714
Rheumatoid factor increased 46.50 13.35 20 32688 1801 79709879
Granulocyte count increased 46.09 13.35 18 32690 1267 79710413
Hernia 45.77 13.35 45 32663 17014 79694666
Pleural thickening 45.72 13.35 23 32685 2959 79708721
Glaucoma 45.51 13.35 48 32660 19713 79691967
Blood magnesium increased 45.00 13.35 24 32684 3482 79708198
Constipation 44.23 13.35 231 32477 282819 79428861
Multiple sclerosis 44.14 13.35 50 32658 22232 79689448
Cardiogenic shock 44.12 13.35 69 32639 41845 79669835
Abdominal distension 42.92 13.35 127 32581 119523 79592157
Diarrhoea 41.78 13.35 547 32161 879942 78831738
Pleural fibrosis 41.13 13.35 24 32684 4143 79707537
Urticaria 40.65 13.35 167 32541 185034 79526646
Gastrooesophageal reflux disease 40.63 13.35 114 32594 104132 79607548
Eye disorder 38.87 13.35 48 32660 23364 79688316
Progressive multifocal leukoencephalopathy 37.07 13.35 44 32664 20556 79691124
Somnolence 36.60 13.35 194 32514 238787 79472893
Pain 36.20 13.35 444 32264 703358 79008322
Blood cholesterol increased 36.07 13.35 95 32613 83625 79628055
Rheumatic disorder 36.04 13.35 20 32688 3138 79708542
Nausea 35.61 13.35 570 32138 956626 78755054
Fatigue 35.09 13.35 555 32153 929172 78782508
Blood immunoglobulin M increased 34.87 13.35 15 32693 1351 79710329
Deafness neurosensory 34.51 13.35 26 32682 6872 79704808
Blood immunoglobulin A decreased 33.98 13.35 15 32693 1438 79710242
Febrile neutropenia 33.92 13.35 27 32681 230972 79480708
Cataract operation 33.90 13.35 23 32685 5162 79706518
Multiple allergies 32.65 13.35 30 32678 10430 79701250
Intentional overdose 32.47 13.35 3 32705 105957 79605723
Interstitial lung disease 32.43 13.35 4 32704 112596 79599084
Cardiac arrest 32.40 13.35 15 32693 172081 79539599
Analgesic therapy 32.23 13.35 13 32695 996 79710684
Sleep disorder therapy 32.04 13.35 13 32695 1011 79710669
Hepatic enzyme abnormal 31.65 13.35 26 32682 7784 79703896
Epigastric discomfort 31.40 13.35 26 32682 7870 79703810
Coordination abnormal 31.19 13.35 37 32671 17275 79694405
Headache 30.85 13.35 406 32302 653366 79058314
Throat clearing 30.81 13.35 17 32691 2637 79709043
Bradycardia 30.25 13.35 9 32699 135548 79576132
Dactylitis 30.21 13.35 17 32691 2740 79708940
Drug therapy 30.04 13.35 13 32695 1188 79710492
Depressed mood 29.56 13.35 63 32645 48417 79663263
Product dose omission issue 29.47 13.35 188 32520 247349 79464331
Joint swelling 29.45 13.35 211 32497 288435 79423245
Joint noise 29.30 13.35 19 32689 3955 79707725
Hand deformity 29.18 13.35 4 32704 103915 79607765
Ascites 28.82 13.35 82 32626 75480 79636200
Urine leukocyte esterase positive 28.79 13.35 19 32689 4072 79707608
Neutropenia 28.75 13.35 46 32662 287664 79424016
Cardio-respiratory arrest 28.60 13.35 5 32703 108505 79603175
Vaginal flatulence 28.55 13.35 16 32692 2559 79709121
Dyspepsia 27.89 13.35 103 32605 108584 79603096
Cataract 27.27 13.35 71 32637 62049 79649631
Throat irritation 27.06 13.35 55 32653 40891 79670789
Osteosclerosis 26.88 13.35 18 32690 3953 79707727
Bone cyst 26.76 13.35 17 32691 3416 79708264
Pain in extremity 26.65 13.35 247 32461 364291 79347389
Blood immunoglobulin G increased 26.33 13.35 16 32692 2973 79708707
Osteopenia 26.31 13.35 35 32673 18329 79693351
Pneumonia aspiration 25.85 13.35 73 32635 66894 79644786
Overdose 25.24 13.35 23 32685 184183 79527497
Pancytopenia 24.80 13.35 19 32689 165726 79545954
Cardiac failure 24.14 13.35 17 32691 154825 79556855
Maternal exposure during pregnancy 24.05 13.35 13 32695 136525 79575155
Cyst 23.98 13.35 29 32679 13811 79697869
Metabolic acidosis 23.60 13.35 3 32705 82526 79629154
Proctitis 23.16 13.35 20 32688 6412 79705268
Blood test abnormal 22.72 13.35 32 32676 17678 79694002
Septic shock 22.66 13.35 11 32697 122790 79588890
Underdose 22.47 13.35 45 32663 33106 79678574
Malignant neoplasm progression 22.45 13.35 14 32694 135976 79575704
Asthenia 21.34 13.35 311 32397 511378 79200302
Blood pressure increased 21.25 13.35 154 32554 211206 79500474
Spinal disorder 20.28 13.35 23 32685 10237 79701443
Sleep disorder 20.17 13.35 79 32629 85598 79626082
Thrombocytopenia 19.98 13.35 50 32658 265209 79446471
Arthralgia 19.85 13.35 337 32371 571466 79140214
Neuropathy peripheral 19.79 13.35 112 32596 141193 79570487
Herpes zoster 19.66 13.35 83 32625 93000 79618680
Ulcer 19.50 13.35 40 32668 29932 79681748
Suicide attempt 19.44 13.35 5 32703 82927 79628753
Bronchitis 19.26 13.35 105 32603 130539 79581141
Hypotension 18.74 13.35 105 32603 440212 79271468
Female genital tract fistula 18.38 13.35 17 32691 5958 79705722
Pemphigus 18.25 13.35 9 32699 99573 79612107
Pruritus 18.11 13.35 244 32464 394404 79317276
Deformity 18.09 13.35 21 32687 9584 79702096
Flatulence 17.91 13.35 48 32660 42676 79669004
Rhabdomyolysis 17.89 13.35 10 32698 103121 79608559
Balance disorder 17.76 13.35 84 32624 98773 79612907
Duodenal ulcer perforation 17.56 13.35 3 32705 66208 79645472
Hyperphosphataemia 17.44 13.35 17 32691 6359 79705321
Exposure during pregnancy 17.27 13.35 10 32698 101122 79610558
Hyperkalaemia 17.25 13.35 13 32695 114385 79597295
White blood cell count decreased 17.12 13.35 134 32574 188154 79523526
Rubber sensitivity 17.07 13.35 10 32698 1739 79709941
Vaginal discharge 16.95 13.35 18 32690 7445 79704235
Systemic lupus erythematosus 16.74 13.35 15 32693 121134 79590546
Alanine aminotransferase increased 16.65 13.35 119 32589 162451 79549229
Glossodynia 16.56 13.35 11 32697 103326 79608354
Nasopharyngitis 16.55 13.35 168 32540 253713 79457967
Lower respiratory tract infection 16.52 13.35 100 32608 129120 79582560
Iron deficiency 16.34 13.35 21 32687 10633 79701047
Adrenal insufficiency 16.20 13.35 36 32672 28451 79683229
Radiculopathy 16.13 13.35 19 32689 8805 79702875
Multiple fractures 15.88 13.35 18 32690 8008 79703672
Diverticulitis 15.74 13.35 48 32660 45888 79665792
Confusional state 15.70 13.35 72 32636 317925 79393755
Vitamin B12 deficiency 15.63 13.35 17 32691 7224 79704456
Skin lesion 15.55 13.35 45 32663 41799 79669881
Skin irritation 15.46 13.35 21 32687 11219 79700461
Hypokalaemia 15.37 13.35 22 32686 144018 79567662
Rheumatoid factor positive 15.25 13.35 3 32705 59836 79651844
Mucosal inflammation 15.16 13.35 6 32702 75574 79636106
Skin reaction 14.93 13.35 25 32683 16043 79695637
Drug reaction with eosinophilia and systemic symptoms 14.82 13.35 4 32704 64240 79647440
Monocyte count increased 14.78 13.35 20 32688 10641 79701039
Colitis microscopic 14.63 13.35 20 32688 10748 79700932
Sciatica 14.61 13.35 38 32670 33184 79678496
Depressed level of consciousness 14.55 13.35 11 32697 96641 79615039
Respiratory arrest 14.42 13.35 3 32705 57547 79654133
Blood pressure systolic decreased 14.19 13.35 20 32688 11056 79700624
Angioedema 13.74 13.35 7 32701 76028 79635652
Respiratory failure 13.69 13.35 34 32674 180877 79530803
Blood creatine phosphokinase increased 13.66 13.35 5 32703 66085 79645595
Bone hypertrophy 13.63 13.35 6 32702 571 79711109
Spinal epidural haematoma 13.48 13.35 8 32700 1424 79710256

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA08 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:37700 protein kinase C inhibitors
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:50846 Immunologic factor
CHEBI has role CHEBI:50855 antiatherogenic drug
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:84735 algal metabolites
MeSH PA D000975 Antioxidants
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obstruction of bile duct indication 30144000
Vitamin E deficiency indication 54137008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.06 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutathione S-transferase P Enzyme IC50 6.30 CHEMBL
Alpha-tocopherol transfer protein Transporter Kd 5.62 CHEMBL

External reference:

IDSource
N0000011305 NUI
10191-41-0 SECONDARY_CAS_RN
4017771 VANDF
CHEBI:18145 CHEBI
VIV PDB_CHEM_ID
CHEMBL2108106 ChEMBL_ID
D06174 KEGG_DRUG
CHEMBL3989727 ChEMBL_ID
CHEMBL47 ChEMBL_ID
C014225 MESH_SUPPLEMENTAL_RECORD_UI
DB11635 DRUGBANK_ID
DB00163 DRUGBANK_ID
159151 RXNORM
11960 MMSL
40928 MMSL
001020 NDDF
009945 NDDF
116776001 SNOMEDCT_US
259666007 SNOMEDCT_US
768524003 SNOMEDCT_US
C0606070 UMLSCUI
D024502 MESH_DESCRIPTOR_UI
71406 PUBCHEM_CID
N9PR3490H9 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 30 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 30 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 30 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 30 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 30 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 15 [iU] ORAL unapproved drug other 10 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 15 [iU] ORAL unapproved drug other 10 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 9 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 10 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 30 [iU] ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 30 [iU] ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 10 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 60 [iU] ORAL UNAPPROVED DRUG OTHER 15 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 20 [iU] ORAL unapproved drug other 7 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
C-Nate DHA HUMAN PRESCRIPTION DRUG LABEL 13 23359-105 CAPSULE, GELATIN COATED 30 [iU] ORAL unapproved drug other 15 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 10 [iU] ORAL unapproved drug other 12 sections
Prenaissance HUMAN PRESCRIPTION DRUG LABEL 9 42192-341 CAPSULE, LIQUID FILLED 30 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-432 TABLET, CHEWABLE 10 mg ORAL Unapproved drug other 6 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-433 TABLET, CHEWABLE 10 mg ORAL Unapproved drug other 6 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-434 TABLET, CHEWABLE 10 mg ORAL Unapproved drug other 6 sections
Kimchi Vitaminchewable multivitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 1.88 mg ORAL unapproved drug other 4 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 20 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 20 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 20 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Vitalipid N HUMAN PRESCRIPTION DRUG LABEL 4 65219-335 EMULSION 1 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 4 sections
Vitalipid N HUMAN PRESCRIPTION DRUG LABEL 4 65219-337 EMULSION 0.70 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 4 sections
Vitalipid N HUMAN PRESCRIPTION DRUG LABEL 4 65219-339 EMULSION 0.70 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 4 sections