All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

piperonyl butoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4276	51-03-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: piperonyl butoxide butacide buticide butocide butoxide butyl carbitol 6-propylpiperonyl ether piperonyl	An insecticide synergist, especially for pyrethroids and ROTENONE. Molecular weight: 338.44 Formula: C19H30O5 CLOGP: 4.40 LIPINSKI: 0 HAC: 5 HDO: 0 TPSA: 46.15 ALOGS: -4.74 ROTB: 13 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 7, 2000	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D010574	Pesticide Synergists
MeSH PA	D010575	Pesticides
CHEBI has role	CHEBI:25943	pesticide synergists

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pediculosis corporis	indication	25188002	DOID:5513
Infestation by Phthirus pubis	indication	71011005	DOID:13760
Pediculosis capitis	indication	81000006	DOID:5501
Bronchospasm	contraindication	4386001
Inflammatory dermatosis	contraindication	703938007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	5.52		CHEMBL
Cytochrome P450	Enzyme		E0V9R7_PEDHC E0VAD1_PEDHC E0VBK5_PEDHC E0VCA5_PEDHC E0VCW8_PEDHC E0VCW9_PEDHC E0VDM3_PEDHC E0VDR0_PEDHC E0VED4_PEDHC E0VGV6_PEDHC E0VHL8_PEDHC E0VHZ1_PEDHC E0VJJ0_PEDHC E0VM29_PEDHC E0VMV6_PEDHC E0VMV7_PEDHC E0VMW9_PEDHC E0VQ45_PEDHC E0VQ46_PEDHC E0VQ47_PEDHC E0VRD2_PEDHC E0VSD4_PEDHC E0VSD5_PEDHC E0VUR0_PEDHC E0VUR1_PEDHC E0VV39_PEDHC E0VV52_PEDHC E0VV70_PEDHC E0VV72_PEDHC E0VXT9_PEDHC E0VZW4_PEDHC E0W115_PEDHC E0W2B1_PEDHC E0W389_PEDHC E0W4F7_PEDHC	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4020346	VUID
N0000148183	NUI
D08383	KEGG_DRUG
4019480	VANDF
4020346	VANDF
C0031962	UMLSCUI
CHEBI:32687	CHEBI
CHEMBL1201131	ChEMBL_ID
D010882	MESH_DESCRIPTOR_UI
DB09350	DRUGBANK_ID
LWK91TU9AH	UNII
5794	PUBCHEM_CID
8345	RXNORM
5306	MMSL
002988	NDDF
32340007	SNOMEDCT_US
412273005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense lice killing	HUMAN OTC DRUG LABEL	2	0113-0866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
good sense lice killing	HUMAN OTC DRUG LABEL	2	0113-0866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
RID Lice Killing	HUMAN OTC DRUG LABEL	2	0280-9000	SHAMPOO	40 mg	TOPICAL	OTC monograph final	15 sections
Walgreens Lice Killing	HUMAN OTC DRUG LABEL	2	0363-1253	SHAMPOO	4 g	TOPICAL	OTC monograph final	14 sections
lice killing	HUMAN OTC DRUG LABEL	2	0904-2528	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Lice Killing	HUMAN OTC DRUG LABEL	2	11383-253	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Lice Killing	HUMAN OTC DRUG LABEL	2	11383-310	SHAMPOO	4 g	TOPICAL	OTC monograph final	14 sections
lice	HUMAN OTC DRUG LABEL	2	11822-0866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Select Brand Lice Killing	HUMAN OTC DRUG LABEL	2	15127-680	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Signature Care Lice Treatment	HUMAN OTC DRUG LABEL	2	21130-085	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
ZAP Lice Killing	HUMAN OTC DRUG LABEL	2	24286-0253	SHAMPOO	4 g	TOPICAL	OTC monograph final	14 sections
Quita Piojos Lice Killing	HUMAN OTC DRUG LABEL	2	24286-1253	SHAMPOO	4 g	TOPICAL	OTC monograph final	14 sections
good neighbor pharmacy Lice	HUMAN OTC DRUG LABEL	2	24385-116	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
lice killing	HUMAN OTC DRUG LABEL	2	30142-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Topcare Lice Killing	HUMAN OTC DRUG LABEL	2	36800-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Topcare Lice Killing	HUMAN OTC DRUG LABEL	2	36800-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
equaline lice killing	HUMAN OTC DRUG LABEL	2	41163-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
equaline lice killing	HUMAN OTC DRUG LABEL	2	41163-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
lice killing	HUMAN OTC DRUG LABEL	2	41250-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
care one lice killing	HUMAN OTC DRUG LABEL	2	41520-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Mata Piojos Lice	HUMAN OTC DRUG LABEL	2	48201-006	SHAMPOO	4 g	TOPICAL	OTC monograph final	12 sections
Mata Piojos Lice	HUMAN OTC DRUG LABEL	2	48201-006	SHAMPOO	4 g	TOPICAL	OTC monograph final	12 sections
equate lice killing	HUMAN OTC DRUG LABEL	2	49035-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
Sunmark Lice KillingMaximum Strength Lice Treatment	HUMAN OTC DRUG LABEL	2	49348-443	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
LIENDREX	HUMAN OTC DRUG LABEL	2	53145-308	SHAMPOO	4 g	TOPICAL	OTC monograph not final	13 sections
LiceOut	HUMAN OTC DRUG LABEL	2	53247-124	SHAMPOO	3 g	TOPICAL	OTC monograph final	13 sections
Liceall	HUMAN OTC DRUG LABEL	2	53247-330	SHAMPOO	3 g	TOPICAL	OTC monograph final	9 sections
Discount Drug Mart Lice Killing	HUMAN OTC DRUG LABEL	2	53943-253	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
family wellness lice killing	HUMAN OTC DRUG LABEL	2	55319-866	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections
El piojito Lice Killing	HUMAN OTC DRUG LABEL	2	55758-253	SHAMPOO	4 g	TOPICAL	OTC monograph final	15 sections