piperonyl butoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4276 51-03-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piperonyl butoxide
  • butacide
  • buticide
  • butocide
  • butoxide
  • butyl carbitol 6-propylpiperonyl ether
  • piperonyl
An insecticide synergist, especially for pyrethroids and ROTENONE.
  • Molecular weight: 338.44
  • Formula: C19H30O5
  • CLOGP: 4.40
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 46.15
  • ALOGS: -4.74
  • ROTB: 13

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 7, 2000 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D010574 Pesticide Synergists
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:25943 pesticide synergists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pediculosis corporis indication 25188002 DOID:5513
Infestation by Phthirus pubis indication 71011005 DOID:13760
Pediculosis capitis indication 81000006 DOID:5501
Bronchospasm contraindication 4386001
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.52 CHEMBL
Cytochrome P450 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4020346 VUID
N0000148183 NUI
D08383 KEGG_DRUG
4019480 VANDF
4020346 VANDF
C0031962 UMLSCUI
CHEBI:32687 CHEBI
CHEMBL1201131 ChEMBL_ID
D010882 MESH_DESCRIPTOR_UI
DB09350 DRUGBANK_ID
LWK91TU9AH UNII
5794 PUBCHEM_CID
8345 RXNORM
5306 MMSL
002988 NDDF
32340007 SNOMEDCT_US
412273005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense lice killing HUMAN OTC DRUG LABEL 2 0113-0866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
good sense lice killing HUMAN OTC DRUG LABEL 2 0113-0866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
RID Lice Killing HUMAN OTC DRUG LABEL 2 0280-9000 SHAMPOO 40 mg TOPICAL OTC monograph final 15 sections
Walgreens Lice Killing HUMAN OTC DRUG LABEL 2 0363-1253 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections
lice killing HUMAN OTC DRUG LABEL 2 0904-2528 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Lice Killing HUMAN OTC DRUG LABEL 2 11383-253 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Lice Killing HUMAN OTC DRUG LABEL 2 11383-310 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections
lice HUMAN OTC DRUG LABEL 2 11822-0866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Select Brand Lice Killing HUMAN OTC DRUG LABEL 2 15127-680 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Signature Care Lice Treatment HUMAN OTC DRUG LABEL 2 21130-085 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
ZAP Lice Killing HUMAN OTC DRUG LABEL 2 24286-0253 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections
Quita Piojos Lice Killing HUMAN OTC DRUG LABEL 2 24286-1253 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections
good neighbor pharmacy Lice HUMAN OTC DRUG LABEL 2 24385-116 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
lice killing HUMAN OTC DRUG LABEL 2 30142-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Topcare Lice Killing HUMAN OTC DRUG LABEL 2 36800-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
equaline lice killing HUMAN OTC DRUG LABEL 2 41163-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
lice killing HUMAN OTC DRUG LABEL 2 41250-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
care one lice killing HUMAN OTC DRUG LABEL 2 41520-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Mata Piojos Lice HUMAN OTC DRUG LABEL 2 48201-006 SHAMPOO 4 g TOPICAL OTC monograph final 12 sections
equate lice killing HUMAN OTC DRUG LABEL 2 49035-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
Sunmark Lice KillingMaximum Strength Lice Treatment HUMAN OTC DRUG LABEL 2 49348-443 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
LIENDREX HUMAN OTC DRUG LABEL 2 53145-308 SHAMPOO 4 g TOPICAL OTC monograph not final 13 sections
LiceOut HUMAN OTC DRUG LABEL 2 53247-124 SHAMPOO 3 g TOPICAL OTC monograph final 13 sections
Liceall HUMAN OTC DRUG LABEL 2 53247-330 SHAMPOO 3 g TOPICAL OTC monograph final 9 sections
Discount Drug Mart Lice Killing HUMAN OTC DRUG LABEL 2 53943-253 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
family wellness lice killing HUMAN OTC DRUG LABEL 2 55319-866 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
El piojito Lice Killing HUMAN OTC DRUG LABEL 2 55758-253 SHAMPOO 4 g TOPICAL OTC monograph final 15 sections
rexall lice killing HUMAN OTC DRUG LABEL 2 55910-705 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections
Mata PiojosA Pediculicide Low Foaming HUMAN OTC DRUG LABEL 2 57501-865 SHAMPOO 2.40 g TOPICAL OTC monograph final 2 sections
medi and lice lice killing HUMAN OTC DRUG LABEL 2 58180-220 SHAMPOO 4 g TOPICAL OTC monograph final 14 sections