stannous fluoride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4273 7783-47-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • stannous fluoride
  • difluorostannylene
  • fluoristan
  • tin difluoride
Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.
  • Molecular weight: 158.72
  • Formula: F2H2Sn
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoaesthesia eye 24.55 23.44 4 607 328 63488083
Completed suicide 24.53 23.44 16 595 145657 63342754

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 126.94 34.68 23 655 1759 34954494
Respiratory tract infection viral 125.22 34.68 24 654 2493 34953760
Cytokine release syndrome 84.90 34.68 27 651 22850 34933403
Fibrin D dimer increased 79.30 34.68 18 660 4226 34952027
Respiratory tract infection 76.15 34.68 24 654 19688 34936565
COVID-19 36.15 34.68 21 657 77529 34878724

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 127.51 22.04 23 1261 2054 79741050
Respiratory tract infection viral 116.88 22.04 24 1260 4235 79738869
Cytokine release syndrome 93.30 22.04 31 1253 35967 79707137
Fibrin D dimer increased 69.77 22.04 18 1266 8636 79734468
Respiratory tract infection 62.57 22.04 25 1259 48664 79694440
Platelet count decreased 41.18 22.04 30 1254 194634 79548470
Pulmonary embolism 39.85 22.04 28 1256 171626 79571478
Hypotension 26.68 22.04 34 1250 440283 79302821
COVID-19 26.04 22.04 21 1263 157653 79585451
Thrombocytopenia 25.42 22.04 26 1258 265233 79477871
C-reactive protein increased 25.24 22.04 19 1265 129008 79614096
Haemoglobin decreased 23.53 22.04 23 1261 222096 79521008

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AA04 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Caries prophylactic agents
MeSH PA D002327 Cariostatic Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of dental caries indication 426482000
Gingivitis off-label use 66383009 DOID:3087
Dental Plaque Prevention off-label use
Dental fluorosis contraindication 30265004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018970 VUID
N0000178988 NUI
D05919 KEGG_DRUG
4018970 VANDF
C0038143 UMLSCUI
CHEBI:135933 CHEBI
CHEMBL1909079 ChEMBL_ID
DB11092 DRUGBANK_ID
3FTR44B32Q UNII
24550 PUBCHEM_CID
10030 RXNORM
21815 MMSL
5509 MMSL
001104 NDDF
329224004 SNOMEDCT_US
42193003 SNOMEDCT_US
D014002 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gel-Kam Fruit and Berry HUMAN OTC DRUG LABEL 1 0126-0165 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 13 sections
Gel-Kam Fruit and Berry HUMAN OTC DRUG LABEL 1 0126-0165 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 13 sections
Gel-Kam Mint HUMAN OTC DRUG LABEL 1 0126-0192 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 13 sections
Gel-Kam Mint HUMAN OTC DRUG LABEL 1 0126-0192 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 13 sections
SENSODYNERepair and Protect Extra Fresh HUMAN OTC DRUG LABEL 1 0135-0547 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERepair and Protect Extra Fresh HUMAN OTC DRUG LABEL 1 0135-0547 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERepair and Protect HUMAN OTC DRUG LABEL 1 0135-0548 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERepair and Protect HUMAN OTC DRUG LABEL 1 0135-0548 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
Sensodyne Complete ProtectionExtra Fresh HUMAN OTC DRUG LABEL 1 0135-0572 PASTE 1.10 mg DENTAL OTC monograph not final 11 sections
Sensodyne Complete ProtectionExtra Fresh HUMAN OTC DRUG LABEL 1 0135-0572 PASTE 1.10 mg DENTAL OTC monograph not final 11 sections
Sensodyne Complete Protection HUMAN OTC DRUG LABEL 1 0135-0573 PASTE 1.10 mg DENTAL OTC monograph not final 11 sections
Sensodyne Complete Protection HUMAN OTC DRUG LABEL 1 0135-0573 PASTE 1.10 mg DENTAL OTC monograph not final 11 sections
SENSODYNERepair and Protect Whitening HUMAN OTC DRUG LABEL 1 0135-0575 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERepair and Protect Whitening HUMAN OTC DRUG LABEL 1 0135-0575 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0598 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0598 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0599 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0599 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0601 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontax HUMAN OTC DRUG LABEL 1 0135-0601 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0621 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0621 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0622 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0622 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
parodontaxComplete Protection HUMAN OTC DRUG LABEL 1 0135-0627 PASTE 1.10 mg DENTAL OTC monograph not final 13 sections
parodontaxComplete Protection HUMAN OTC DRUG LABEL 1 0135-0627 PASTE 1.10 mg DENTAL OTC monograph not final 13 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0632 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
SENSODYNERapid Relief HUMAN OTC DRUG LABEL 1 0135-0632 PASTE 1.10 mg ORAL OTC monograph not final 11 sections
parodontaxComplete Protection HUMAN OTC DRUG LABEL 1 0135-0634 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections
parodontaxComplete Protection HUMAN OTC DRUG LABEL 1 0135-0634 PASTE 1.10 mg DENTAL OTC monograph not final 12 sections