stannous fluoride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4273	7783-47-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: stannous fluoride difluorostannylene fluoristan tin difluoride	Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries. Molecular weight: 158.72 Formula: F2H2Sn CLOGP: -1.32 LIPINSKI: None HAC: 0 HDO: 0 TPSA: ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

stannous fluoride
difluorostannylene
fluoristan
tin difluoride

Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.

Molecular weight: 158.72
Formula: F2H2Sn
CLOGP: -1.32
LIPINSKI: None
HAC: 0
HDO: 0
TPSA:
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoaesthesia eye	24.55	23.44	4	607	328	63488083
Completed suicide	24.53	23.44	16	595	145657	63342754

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	126.94	34.68	23	655	1759	34954494
Respiratory tract infection viral	125.22	34.68	24	654	2493	34953760
Cytokine release syndrome	84.90	34.68	27	651	22850	34933403
Fibrin D dimer increased	79.30	34.68	18	660	4226	34952027
Respiratory tract infection	76.15	34.68	24	654	19688	34936565
COVID-19	36.15	34.68	21	657	77529	34878724

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	127.51	22.04	23	1261	2054	79741050
Respiratory tract infection viral	116.88	22.04	24	1260	4235	79738869
Cytokine release syndrome	93.30	22.04	31	1253	35967	79707137
Fibrin D dimer increased	69.77	22.04	18	1266	8636	79734468
Respiratory tract infection	62.57	22.04	25	1259	48664	79694440
Platelet count decreased	41.18	22.04	30	1254	194634	79548470
Pulmonary embolism	39.85	22.04	28	1256	171626	79571478
Hypotension	26.68	22.04	34	1250	440283	79302821
COVID-19	26.04	22.04	21	1263	157653	79585451
Thrombocytopenia	25.42	22.04	26	1258	265233	79477871

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A01AA04	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
MeSH PA	D002327	Cariostatic Agents
MeSH PA	D020011	Protective Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Prevention of dental caries	indication	426482000
Gingivitis	off-label use	66383009	DOID:3087
Dental Plaque Prevention	off-label use
Dental fluorosis	contraindication	30265004

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

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Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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External reference:

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ID	Source
001104	NDDF
10030	RXNORM
21815	MMSL
24550	PUBCHEM_CID
329224004	SNOMEDCT_US
3FTR44B32Q	UNII
4018970	VUID
4018970	VANDF
42193003	SNOMEDCT_US
5509	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Gel-Kam Fruit and Berry	HUMAN OTC DRUG LABEL	1	0126-0165	GEL, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	13 sections
Gel-Kam Fruit and Berry	HUMAN OTC DRUG LABEL	1	0126-0165	GEL, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	13 sections
Gel-Kam Mint	HUMAN OTC DRUG LABEL	1	0126-0192	GEL, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	13 sections
Gel-Kam Mint	HUMAN OTC DRUG LABEL	1	0126-0192	GEL, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	13 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0598	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0598	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0599	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0599	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0601	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections
parodontax	HUMAN OTC DRUG LABEL	1	0135-0601	PASTE	1.10 mg	DENTAL	OTC monograph not final	12 sections

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