sodium phosphate, monobasic 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4271	7558-80-7

Description:

Molecule	Description
Synonyms: sodium phosphate, monobasic dihydrogen monosodium phosphate phosphoric acid monosodium salt monobasic sodium phosphate monosodium dihydrogen orthophosphate	Molecular weight: 119.98 Formula: H2NaO4P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium phosphate, monobasic
dihydrogen monosodium phosphate
phosphoric acid monosodium salt
monobasic sodium phosphate
monosodium dihydrogen orthophosphate

Molecular weight: 119.98
Formula: H2NaO4P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Intestinal pseudo-obstruction	85.86	25.90	16	1909	896	63486201
Cytokine release syndrome	57.14	25.90	20	1905	14294	63472803
Delirium	38.25	25.90	22	1903	50519	63436578
Loss of bladder sensation	34.69	25.90	5	1920	54	63487043
Mutism	32.76	25.90	8	1917	1622	63485475
Encephalopathy	32.43	25.90	18	1907	38602	63448495
Food refusal	31.63	25.90	6	1919	369	63486728
Cholelithiasis	30.27	25.90	18	1907	43907	63443190
Vomiting	28.24	25.90	56	1869	559561	62927536
Urinary retention	27.86	25.90	15	1910	30286	63456811
Acute kidney injury	26.40	25.90	36	1889	263379	63223718

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	507.13	36.88	134	4523	8467	34943807
Appendicitis	439.39	36.88	135	4522	14672	34937602
Cardiogenic shock	369.10	36.88	137	4520	26481	34925793
Stress	348.07	36.88	136	4521	30211	34922063
Ascites	291.92	36.88	136	4521	46435	34905839
Ventricular fibrillation	277.62	36.88	107	4550	22847	34929427
Abdominal distension	274.08	36.88	140	4517	58352	34893922
Multiple organ dysfunction syndrome	233.44	36.88	138	4519	76428	34875846
Blood phosphorus increased	231.21	36.88	71	4586	7650	34944624
Hyponatraemia	228.74	36.88	140	4517	82551	34869723
Sepsis	172.38	36.88	156	4501	166405	34785869
General physical health deterioration	168.94	36.88	138	4519	128131	34824143
Abdominal pain	164.87	36.88	151	4506	163467	34788807
Dry mouth	128.80	36.88	68	4589	30097	34922177
Vomiting	116.31	36.88	153	4504	247468	34704806
Aplastic anaemia	109.12	36.88	43	4614	9673	34942601
Myasthenia gravis	108.02	36.88	39	4618	6901	34945373
Blood uric acid increased	102.52	36.88	41	4616	9583	34942691
Nausea	82.33	36.88	155	4502	339753	34612521
Blood cholesterol increased	75.60	36.88	42	4615	20501	34931773
Hyperphosphataemia	69.27	36.88	25	4632	4412	34947862
Somnolence	65.19	36.88	77	4580	111039	34841235
Drug therapy	58.68	36.88	16	4641	1125	34951149
Iron deficiency	57.54	36.88	23	4634	5358	34946916
Incorrect route of product administration	56.38	36.88	31	4626	14814	34937460
Lymphocyte count decreased	51.51	36.88	34	4623	22588	34929686
Sleep disorder therapy	51.01	36.88	14	4643	1009	34951265
Hypophosphataemia	50.25	36.88	26	4631	11000	34941274
Hypogonadism	47.93	36.88	16	4641	2239	34950035
Analgesic therapy	46.73	36.88	13	4644	985	34951289

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	564.79	25.55	133	6499	8418	79729338
Appendicitis	451.97	25.55	134	6498	20660	79717096
Cardiogenic shock	381.91	25.55	140	6492	41774	79695982
Ventricular fibrillation	291.99	25.55	107	6525	31819	79705937
Ascites	289.71	25.55	136	6496	75426	79662330
Stress	279.90	25.55	135	6497	79477	79658279
Abdominal distension	260.22	25.55	147	6485	119503	79618253
Blood phosphorus increased	247.98	25.55	72	6560	10275	79727481
Multiple organ dysfunction syndrome	243.41	25.55	141	6491	120105	79617651
Sepsis	196.51	25.55	169	6463	269259	79468497
Hyponatraemia	195.20	25.55	142	6490	177706	79560050
General physical health deterioration	144.84	25.55	144	6488	275094	79462662
Abdominal pain	127.56	25.55	159	6473	389410	79348346
Aplastic anaemia	123.85	25.55	49	6583	17856	79719900
Vomiting	113.82	25.55	200	6432	665628	79072128
Myasthenia gravis	110.52	25.55	39	6593	10360	79727396
Blood uric acid increased	108.17	25.55	41	6591	13319	79724437
Dry mouth	91.16	25.55	68	6564	87951	79649805
Hyperphosphataemia	71.91	25.55	25	6607	6351	79731405
Drug therapy	65.34	25.55	16	6616	1185	79736571
Cytokine release syndrome	61.65	25.55	38	6594	35960	79701796
Hypogonadism	59.27	25.55	16	6616	1744	79736012
Hypophosphataemia	58.62	25.55	30	6602	19883	79717873
Sleep disorder therapy	57.53	25.55	14	6618	1010	79736746
Intestinal pseudo-obstruction	57.38	25.55	17	6615	2592	79735164
Somnolence	57.26	25.55	84	6548	238897	79498859
Lymphocyte count decreased	56.81	25.55	40	6592	47249	79690507
Iron deficiency	52.82	25.55	23	6609	10631	79727125
Analgesic therapy	52.65	25.55	13	6619	996	79736760
Incision site pain	51.76	25.55	16	6616	2814	79734942
Nausea	48.91	25.55	182	6450	957014	78780742
Condition aggravated	46.93	25.55	118	6514	501006	79236750
Incorrect route of product administration	45.36	25.55	31	6601	34898	79702858
Off label use	45.06	25.55	171	6461	907044	78830712
Blood cholesterol increased	40.53	25.55	42	6590	83678	79654078
Red blood cells urine positive	39.32	25.55	15	6617	4948	79732808
Blood urea increased	36.15	25.55	31	6601	48759	79688997
Neuralgia	32.76	25.55	25	6607	33359	79704397
Drug ineffective	31.95	25.55	26	6606	1080887	78656869
Bacterial infection	29.76	25.55	23	6609	31257	79706499
Mucosal inflammation	29.74	25.55	34	6598	75546	79662210
Protein urine present	29.08	25.55	15	6617	10097	79727659
Loss of bladder sensation	26.96	25.55	5	6627	96	79737660
Neutrophil count increased	26.63	25.55	21	6611	29375	79708381
Dizziness	25.97	25.55	6	6626	526435	79211321
Mutism	25.59	25.55	9	6623	2363	79735393

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypophosphatemia	indication	4996001
Constipation	indication	14760008	DOID:2089
Urinary tract infectious disease	indication	68566005
Incomplete passage of stool	indication	249515001
Calcium renal calculus	indication	427649000
Osteopenia of prematurity	off-label use	276703007
Fluid volume disorder	contraindication	1860003
Anuria	contraindication	2472002	DOID:2983
Gastritis	contraindication	4556007	DOID:4029
Hypocalcemia	contraindication	5291005
Asthenia	contraindication	13791008
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Disorder of autonomic nervous system	contraindication	15241006
Lowered convulsive threshold	contraindication	19260006
Cirrhosis of liver	contraindication	19943007	DOID:5082
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Glaucoma	contraindication	23986001	DOID:1686
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Toxic megacolon	contraindication	28536002	DOID:1770
Hypovolemia	contraindication	28560003
Atony of colon	contraindication	29479008
Torsades de pointes	contraindication	31722008
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypernatremia	contraindication	39355002
Hypovolemic shock	contraindication	39419009
Gastrointestinal ulcer	contraindication	40845000
Hypokalemia	contraindication	43339004
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Nephrocalcinosis	contraindication	48638002	DOID:12679
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Gastrointestinal perforation	contraindication	51875005
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Paralytic ileus	contraindication	55525008	DOID:8442
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Colitis	contraindication	64226004	DOID:0060180
Blood coagulation disorder	contraindication	64779008	DOID:1247
Hyperparathyroidism	contraindication	66999008	DOID:13543
Aortocoronary artery bypass graft	contraindication	67166004
Esophagogastrostomy	contraindication	70676003
Diabetes mellitus	contraindication	73211009	DOID:9351
Factor II deficiency	contraindication	73975000
Appendicitis	contraindication	74400008	DOID:8337
Gastrointestinal hemorrhage	contraindication	74474003
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Oliguria	contraindication	83128009
Hiatal hernia	contraindication	84089009	DOID:12642
Cardiomyopathy	contraindication	85898001	DOID:0050700
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Thyrotoxicosis	contraindication	90739004	DOID:7997
Hemophilia	contraindication	90935002
Myasthenia gravis	contraindication	91637004	DOID:437
Anemia due to enzyme deficiency	contraindication	111577008
Prolonged QT interval	contraindication	111975006
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Gastrointestinal obstruction	contraindication	126765001
Seizure disorder	contraindication	128613002
Liver function tests abnormal	contraindication	166603001
Alcohol withdrawal syndrome	contraindication	191480000
Decompensated cardiac failure	contraindication	195111005
Acute constipation	contraindication	197119006
Impaired renal function disorder	contraindication	197663003
Imperforate anus	contraindication	204731006	DOID:10488
Stapling of stomach	contraindication	235245007
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Hyporeninemic hypoaldosteronism	contraindication	236464008
Bladder outflow obstruction	contraindication	236645006
Pyloric obstruction	contraindication	244815007
Benign prostatic hyperplasia	contraindication	266569009
Edema	contraindication	267038008
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Gastric retention	contraindication	307227006
Congenital megacolon	contraindication	360436002
Macrocolon	contraindication	367495003
Ascites	contraindication	389026000
Acute coronary syndrome	contraindication	394659003
Cardiovascular event risk	contraindication	395112001
Colostomy	contraindication	398740003
Breastfeeding (mother)	contraindication	413712001
Disorder of coronary artery	contraindication	414024009
Myocardial infarction in recovery phase	contraindication	418044006
Gastrointestinal hypomotility	contraindication	421807004
Fever greater than 100.4 Fahrenheit	contraindication	426000000
Congenital long QT syndrome	contraindication	442917000
Azotemia	contraindication	445009001
Severe dehydration	contraindication	450316000
Seizure due to Abrupt Benzodiazepine Withdrawal	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018072	VUID
N0000146412	NUI
4017619	VANDF
4018072	VANDF
C0770578	UMLSCUI
CHEBI:37585	CHEBI
CHEMBL1368	ChEMBL_ID
DB09449	DRUGBANK_ID
C018279	MESH_SUPPLEMENTAL_RECORD_UI
23672064	PUBCHEM_CID
235496	RXNORM
5208	MMSL
5469	MMSL
5474	MMSL
NOCODE	MMSL
d01009	MMSL
d03095	MMSL
000761	NDDF
002336	NDDF
116124008	SNOMEDCT_US

Pharmaceutical products:

None