sodium phosphate, monobasic 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4271 7558-80-7

Description:

MoleculeDescription

Synonyms:

  • sodium phosphate, monobasic
  • dihydrogen monosodium phosphate
  • phosphoric acid monosodium salt
  • monobasic sodium phosphate
  • monosodium dihydrogen orthophosphate
  • Molecular weight: 119.98
  • Formula: H2NaO4P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intestinal pseudo-obstruction 85.86 25.90 16 1909 896 63486201
Cytokine release syndrome 57.14 25.90 20 1905 14294 63472803
Delirium 38.25 25.90 22 1903 50519 63436578
Loss of bladder sensation 34.69 25.90 5 1920 54 63487043
Mutism 32.76 25.90 8 1917 1622 63485475
Encephalopathy 32.43 25.90 18 1907 38602 63448495
Food refusal 31.63 25.90 6 1919 369 63486728
Cholelithiasis 30.27 25.90 18 1907 43907 63443190
Vomiting 28.24 25.90 56 1869 559561 62927536
Urinary retention 27.86 25.90 15 1910 30286 63456811
Acute kidney injury 26.40 25.90 36 1889 263379 63223718

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 507.13 36.88 134 4523 8467 34943807
Appendicitis 439.39 36.88 135 4522 14672 34937602
Cardiogenic shock 369.10 36.88 137 4520 26481 34925793
Stress 348.07 36.88 136 4521 30211 34922063
Ascites 291.92 36.88 136 4521 46435 34905839
Ventricular fibrillation 277.62 36.88 107 4550 22847 34929427
Abdominal distension 274.08 36.88 140 4517 58352 34893922
Multiple organ dysfunction syndrome 233.44 36.88 138 4519 76428 34875846
Blood phosphorus increased 231.21 36.88 71 4586 7650 34944624
Hyponatraemia 228.74 36.88 140 4517 82551 34869723
Sepsis 172.38 36.88 156 4501 166405 34785869
General physical health deterioration 168.94 36.88 138 4519 128131 34824143
Abdominal pain 164.87 36.88 151 4506 163467 34788807
Dry mouth 128.80 36.88 68 4589 30097 34922177
Vomiting 116.31 36.88 153 4504 247468 34704806
Aplastic anaemia 109.12 36.88 43 4614 9673 34942601
Myasthenia gravis 108.02 36.88 39 4618 6901 34945373
Blood uric acid increased 102.52 36.88 41 4616 9583 34942691
Nausea 82.33 36.88 155 4502 339753 34612521
Blood cholesterol increased 75.60 36.88 42 4615 20501 34931773
Hyperphosphataemia 69.27 36.88 25 4632 4412 34947862
Somnolence 65.19 36.88 77 4580 111039 34841235
Drug therapy 58.68 36.88 16 4641 1125 34951149
Iron deficiency 57.54 36.88 23 4634 5358 34946916
Incorrect route of product administration 56.38 36.88 31 4626 14814 34937460
Lymphocyte count decreased 51.51 36.88 34 4623 22588 34929686
Sleep disorder therapy 51.01 36.88 14 4643 1009 34951265
Hypophosphataemia 50.25 36.88 26 4631 11000 34941274
Hypogonadism 47.93 36.88 16 4641 2239 34950035
Analgesic therapy 46.73 36.88 13 4644 985 34951289

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 564.79 25.55 133 6499 8418 79729338
Appendicitis 451.97 25.55 134 6498 20660 79717096
Cardiogenic shock 381.91 25.55 140 6492 41774 79695982
Ventricular fibrillation 291.99 25.55 107 6525 31819 79705937
Ascites 289.71 25.55 136 6496 75426 79662330
Stress 279.90 25.55 135 6497 79477 79658279
Abdominal distension 260.22 25.55 147 6485 119503 79618253
Blood phosphorus increased 247.98 25.55 72 6560 10275 79727481
Multiple organ dysfunction syndrome 243.41 25.55 141 6491 120105 79617651
Sepsis 196.51 25.55 169 6463 269259 79468497
Hyponatraemia 195.20 25.55 142 6490 177706 79560050
General physical health deterioration 144.84 25.55 144 6488 275094 79462662
Abdominal pain 127.56 25.55 159 6473 389410 79348346
Aplastic anaemia 123.85 25.55 49 6583 17856 79719900
Vomiting 113.82 25.55 200 6432 665628 79072128
Myasthenia gravis 110.52 25.55 39 6593 10360 79727396
Blood uric acid increased 108.17 25.55 41 6591 13319 79724437
Dry mouth 91.16 25.55 68 6564 87951 79649805
Hyperphosphataemia 71.91 25.55 25 6607 6351 79731405
Drug therapy 65.34 25.55 16 6616 1185 79736571
Cytokine release syndrome 61.65 25.55 38 6594 35960 79701796
Hypogonadism 59.27 25.55 16 6616 1744 79736012
Hypophosphataemia 58.62 25.55 30 6602 19883 79717873
Sleep disorder therapy 57.53 25.55 14 6618 1010 79736746
Intestinal pseudo-obstruction 57.38 25.55 17 6615 2592 79735164
Somnolence 57.26 25.55 84 6548 238897 79498859
Lymphocyte count decreased 56.81 25.55 40 6592 47249 79690507
Iron deficiency 52.82 25.55 23 6609 10631 79727125
Analgesic therapy 52.65 25.55 13 6619 996 79736760
Incision site pain 51.76 25.55 16 6616 2814 79734942
Nausea 48.91 25.55 182 6450 957014 78780742
Condition aggravated 46.93 25.55 118 6514 501006 79236750
Incorrect route of product administration 45.36 25.55 31 6601 34898 79702858
Off label use 45.06 25.55 171 6461 907044 78830712
Blood cholesterol increased 40.53 25.55 42 6590 83678 79654078
Red blood cells urine positive 39.32 25.55 15 6617 4948 79732808
Blood urea increased 36.15 25.55 31 6601 48759 79688997
Neuralgia 32.76 25.55 25 6607 33359 79704397
Drug ineffective 31.95 25.55 26 6606 1080887 78656869
Bacterial infection 29.76 25.55 23 6609 31257 79706499
Mucosal inflammation 29.74 25.55 34 6598 75546 79662210
Protein urine present 29.08 25.55 15 6617 10097 79727659
Loss of bladder sensation 26.96 25.55 5 6627 96 79737660
Neutrophil count increased 26.63 25.55 21 6611 29375 79708381
Dizziness 25.97 25.55 6 6626 526435 79211321
Mutism 25.59 25.55 9 6623 2363 79735393

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypophosphatemia indication 4996001
Constipation indication 14760008 DOID:2089
Urinary tract infectious disease indication 68566005
Incomplete passage of stool indication 249515001
Calcium renal calculus indication 427649000
Osteopenia of prematurity off-label use 276703007
Fluid volume disorder contraindication 1860003
Anuria contraindication 2472002 DOID:2983
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperphosphatemia contraindication 20165001 DOID:0050459
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Toxic megacolon contraindication 28536002 DOID:1770
Hypovolemia contraindication 28560003
Atony of colon contraindication 29479008
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Nephrocalcinosis contraindication 48638002 DOID:12679
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Paralytic ileus contraindication 55525008 DOID:8442
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Colitis contraindication 64226004 DOID:0060180
Blood coagulation disorder contraindication 64779008 DOID:1247
Hyperparathyroidism contraindication 66999008 DOID:13543
Aortocoronary artery bypass graft contraindication 67166004
Esophagogastrostomy contraindication 70676003
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Cardiomyopathy contraindication 85898001 DOID:0050700
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Alcohol withdrawal syndrome contraindication 191480000
Decompensated cardiac failure contraindication 195111005
Acute constipation contraindication 197119006
Impaired renal function disorder contraindication 197663003
Imperforate anus contraindication 204731006 DOID:10488
Stapling of stomach contraindication 235245007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Gastric retention contraindication 307227006
Congenital megacolon contraindication 360436002
Macrocolon contraindication 367495003
Ascites contraindication 389026000
Acute coronary syndrome contraindication 394659003
Cardiovascular event risk contraindication 395112001
Colostomy contraindication 398740003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006
Gastrointestinal hypomotility contraindication 421807004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Congenital long QT syndrome contraindication 442917000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Seizure due to Abrupt Benzodiazepine Withdrawal contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018072 VUID
N0000146412 NUI
4017619 VANDF
4018072 VANDF
C0770578 UMLSCUI
CHEBI:37585 CHEBI
CHEMBL1368 ChEMBL_ID
DB09449 DRUGBANK_ID
C018279 MESH_SUPPLEMENTAL_RECORD_UI
23672064 PUBCHEM_CID
235496 RXNORM
5208 MMSL
5469 MMSL
5474 MMSL
NOCODE MMSL
d01009 MMSL
d03095 MMSL
000761 NDDF
002336 NDDF
116124008 SNOMEDCT_US

Pharmaceutical products:

None