sodium phosphate, monobasic Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4271 7558-80-7

Description:

MoleculeDescription

Synonyms:

  • sodium phosphate, monobasic
  • dihydrogen monosodium phosphate
  • phosphoric acid monosodium salt
  • monobasic sodium phosphate
  • monosodium dihydrogen orthophosphate
  • Molecular weight: 119.98
  • Formula: H2NaO4P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intestinal pseudo-obstruction 80.58 22.33 16 2645 755 53345650
Cytokine release syndrome 39.61 22.33 15 2646 8114 53338291
Delirium 37.01 22.33 24 2637 41405 53305000
Acute phosphate nephropathy 34.95 22.33 5 2656 29 53346376
Loss of bladder sensation 32.93 22.33 5 2656 46 53346359
Mutism 29.94 22.33 8 2653 1405 53345000
Lymphocyte count decreased 29.43 22.33 18 2643 28034 53318371
Urinary retention 26.67 22.33 17 2644 28449 53317956
Constipation 24.54 22.33 39 2622 198373 53148032
Febrile neutropenia 24.29 22.33 28 2633 104908 53241497
Urinary tract infection 24.15 22.33 43 2618 239860 53106545
Product selection error 22.96 22.33 4 2657 91 53346314

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 241.81 22.52 58 3380 3107 32506981
Appendicitis 190.51 22.52 60 3378 8877 32501211
Cardiogenic shock 144.78 22.52 61 3377 20601 32489487
Stress 130.15 22.52 59 3379 23723 32486365
Ascites 106.23 22.52 61 3377 40130 32469958
Constipation 103.70 22.52 94 3344 126279 32383809
Abdominal distension 102.38 22.52 65 3373 51230 32458858
Hyponatraemia 82.65 22.52 66 3372 74447 32435641
Multiple organ dysfunction syndrome 77.73 22.52 62 3376 69792 32440296
Sepsis 75.29 22.52 88 3350 158746 32351342
Lymphocyte count decreased 74.98 22.52 39 3399 21080 32489008
Abdominal pain 69.43 22.52 82 3356 149447 32360641
General physical health deterioration 54.72 22.52 64 3374 115195 32394893
Vomiting 53.78 22.52 92 3346 235465 32274623
Ventricular fibrillation 53.06 22.52 29 3409 17281 32492807
Incision site pain 44.68 22.52 14 3424 2023 32508065
Nausea 38.35 22.52 96 3342 320753 32189335
Red blood cells urine positive 38.03 22.52 12 3426 1774 32508314
Blood urea increased 34.43 22.52 28 3410 32245 32477843
Neutrophil count increased 33.50 22.52 21 3417 16093 32493995
Protein urine present 32.17 22.52 14 3424 5083 32505005
Aplastic anaemia 24.38 22.52 13 3425 7360 32502728

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypophosphatemia indication 4996001
Constipation indication 14760008 DOID:2089
Urinary tract infectious disease indication 68566005
Incomplete passage of stool indication 249515001
Calcium renal calculus indication 427649000
Osteopenia of prematurity off-label use 276703007
Fluid volume disorder contraindication 1860003
Anuria contraindication 2472002 DOID:2983
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperphosphatemia contraindication 20165001 DOID:0050459
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Toxic megacolon contraindication 28536002 DOID:1770
Hypovolemia contraindication 28560003
Atony of colon contraindication 29479008
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Nephrocalcinosis contraindication 48638002 DOID:12679
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Paralytic ileus contraindication 55525008 DOID:8442
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Colitis contraindication 64226004 DOID:0060180
Blood coagulation disorder contraindication 64779008 DOID:1247
Hyperparathyroidism contraindication 66999008 DOID:13543
Aortocoronary artery bypass graft contraindication 67166004
Esophagogastrostomy contraindication 70676003
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Cardiomyopathy contraindication 85898001 DOID:0050700
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Alcohol withdrawal syndrome contraindication 191480000
Decompensated cardiac failure contraindication 195111005
Acute constipation contraindication 197119006
Impaired renal function disorder contraindication 197663003
Imperforate anus contraindication 204731006 DOID:10488
Stapling of stomach contraindication 235245007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Gastric retention contraindication 307227006
Congenital megacolon contraindication 360436002
Macrocolon contraindication 367495003
Ascites contraindication 389026000
Acute coronary syndrome contraindication 394659003
Cardiovascular event risk contraindication 395112001
Colostomy contraindication 398740003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006
Gastrointestinal hypomotility contraindication 421807004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Congenital long QT syndrome contraindication 442917000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Seizure due to Abrupt Benzodiazepine Withdrawal contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018072 VUID
N0000146412 NUI
4017619 VANDF
4018072 VANDF
C0770578 UMLSCUI
CHEBI:37585 CHEBI
CHEMBL1368 ChEMBL_ID
DB09449 DRUGBANK_ID
C018279 MESH_SUPPLEMENTAL_RECORD_UI
23672064 PUBCHEM_CID
235496 RXNORM
5208 MMSL
5469 MMSL
5474 MMSL
NOCODE MMSL
d01009 MMSL
d03095 MMSL
000761 NDDF
002336 NDDF
116124008 SNOMEDCT_US

Pharmaceutical products:

None