arbutin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4267 497-76-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • arbutin
  • arbutine
  • arbutoside
  • arbutyne
  • hydroquinone glucose
  • Molecular weight: 272.25
  • Formula: C12H16O7
  • CLOGP: -1
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 5
  • TPSA: 119.61
  • ALOGS: -0.84
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.87 acidic
pKa2 11.99 acidic
pKa3 12.61 acidic
pKa4 13.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosinase Enzyme IC50 4.52 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 4 CHEMBL
Tyrosinase Enzyme IC50 4.52 CHEMBL

External reference:

IDSource
N0000168438 NUI
C0003729 UMLSCUI
CHEBI:18305 CHEBI
7OQ PDB_CHEM_ID
CHEMBL232202 ChEMBL_ID
D001104 MESH_DESCRIPTOR_UI
DB11217 DRUGBANK_ID
C5INA23HXF UNII
440936 PUBCHEM_CID
1367175 RXNORM

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dr G Whitening FORTIFIER by EGF HUMAN OTC DRUG LABEL 2 43948-4001 CREAM 0.60 mL TOPICAL OTC monograph final 8 sections
Dr G Whitening REFORMER by EGF HUMAN OTC DRUG LABEL 2 43948-4002 CREAM 1 mL TOPICAL OTC monograph final 8 sections
Dr Young 2p Brightening UV Sun Block SPF50 PA HUMAN OTC DRUG LABEL 1 43948-5002 CREAM 0.50 mL TOPICAL OTC monograph final 8 sections
Dr Young 2p Brightening UV Sun Block SPF50 PA HUMAN OTC DRUG LABEL 2 43948-5003 CREAM 0.50 mL TOPICAL OTC monograph final 6 sections
Super Plus Beblesh Balm Triple Functions SPF50 Plus PA 3Plus (40g) HUMAN OTC DRUG LABEL 6 49715-007 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
The Prestige BB SPF25 PA 2Plus HUMAN OTC DRUG LABEL 4 49715-008 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
The Oriental Gold BB SPF25 PA 2Plus HUMAN OTC DRUG LABEL 4 49715-010 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
Absolute Total BB SPF37 PA 3Plus HUMAN OTC DRUG LABEL 4 49715-011 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
SuperPlus Beblesh Balm Triple Functions SPF25 PA 2Plus HUMAN OTC DRUG LABEL 6 49715-014 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
SuperPlus Beblesh Balm Gold SPF25 PA 2Plus HUMAN OTC DRUG LABEL 4 49715-015 CREAM 0.50 g TOPICAL OTC monograph final 10 sections
SuperPlus Beblesh Balm Gold SPF25 PA 2Plus HUMAN OTC DRUG LABEL 6 49715-016 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
SuperPlus Beblesh Balm SPF25 PA 2Plus HUMAN OTC DRUG LABEL 4 49715-017 CREAM 0.50 g TOPICAL OTC monograph final 10 sections
SuperPlus Beblesh Balm SPF25 PA 2Plus HUMAN OTC DRUG LABEL 6 49715-018 CREAM 0.80 g TOPICAL OTC monograph final 10 sections
SKIN79 SNAIL NUTRITION BBCREAM HUMAN OTC DRUG LABEL 5 49715-019 CREAM 0.80 g TOPICAL OTC monograph final 3 sections
Skin-ion HUMAN OTC DRUG LABEL 3 49742-1001 SPRAY 0.80 mL TOPICAL OTC monograph final 6 sections
Derma Blemish Balmblemish balm HUMAN OTC DRUG LABEL 3 52554-4001 CREAM 0.02 mL TOPICAL unapproved drug other 6 sections
ISAKNOX WHITE SYMPHONY BRIGHTENING EMULSION HUMAN OTC DRUG LABEL 1 53208-385 LOTION 2.10 g TOPICAL OTC monograph not final 12 sections
Sooryehan Pure-Whitening Essential Starter HUMAN OTC DRUG LABEL 1 53208-445 CREAM 2.10 mL TOPICAL unapproved drug other 12 sections
OHUI Sun Science Sun Block EX plus Beige HUMAN OTC DRUG LABEL 6 53208-524 POWDER 2 g TOPICAL OTC monograph not final 5 sections
OHUI White Extreme Illuminating Pact No.10 HUMAN OTC DRUG LABEL 4 53208-533 POWDER 2 g TOPICAL OTC monograph not final 6 sections
OHUI White Extreme Illuminating Pact No.10 HUMAN OTC DRUG LABEL 4 53208-534 POWDER 2 g TOPICAL OTC monograph not final 6 sections
Tosowoong Mens Booster Repair Skin HUMAN OTC DRUG LABEL 1 55249-1001 LIQUID 1 mg TOPICAL unapproved drug other 7 sections
Conju Princess BB HUMAN OTC DRUG LABEL 3 59915-1001 CREAM 2 mL TOPICAL unapproved drug other 8 sections
Conju Princess BB HUMAN OTC DRUG LABEL 3 59915-3001 CREAM 2 mL TOPICAL unapproved drug other 8 sections
ABALONE CRYSTALDOUBLE EX AMPOULE HUMAN OTC DRUG LABEL 2 60611-0006 LIQUID 2.20 g TOPICAL unapproved drug other 7 sections
HYDRO H HUMAN OTC DRUG LABEL 1 69422-5001 SOLUTION 2.50 mg TOPICAL unapproved drug other 7 sections
D-ONE BY TAMDOAN SUNSCREEN 50 HUMAN OTC DRUG LABEL 8 70931-0001 CREAM 2 g TOPICAL unapproved drug other 8 sections
D-ONE BY TAMDOAN BB MEDIUM HUMAN OTC DRUG LABEL 8 70931-0003 CREAM 2 g TOPICAL unapproved drug other 7 sections
Wonder Intensive BBCream 21 (Light) HUMAN OTC DRUG LABEL 8 70931-0005 CREAM 2 g TOPICAL unapproved drug other 7 sections
CELLBN DAMAGE OVERNIGHT RECOVERY HUMAN OTC DRUG LABEL 2 71450-0001 CREAM 2 g TOPICAL unapproved drug other 7 sections