phenol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4266 108-95-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenol
  • hydroxybenzene
An antiseptic and disinfectant aromatic alcohol.
  • Molecular weight: 94.11
  • Formula: C6H6O
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -0.31
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cystitis-like symptom 25.44 22.94 3 890 9 46685160

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC C05BB05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Sclerosing agents for local injection
ATC D08AE03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Phenol and derivatives
ATC N01BX03 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Other local anesthetics
ATC R02AA19 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004202 Disinfectants
MeSH PA D019999 Pharmaceutical Solutions
MeSH PA D012597 Sclerosing Solutions
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Mouth Irritation indication
Herpes zoster contraindication 4740000 DOID:8536
Bacterial septicemia contraindication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Shock contraindication 27942005
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Conduction disorder of the heart contraindication 44808001
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Incontinence of feces contraindication 72042002
Diabetes mellitus contraindication 73211009 DOID:9351
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Decreased respiratory function contraindication 80954004
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 5.26 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.04 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.02 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.57 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.94 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Endolysin Enzyme Kd 4.04 CHEMBL
Carbonic anhydrase 2 Unclassified Ki 4.59 CHEMBL
Carbonic anhydrase Unclassified Ki 4.86 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 4.10 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.19 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 4.98 CHEMBL
Carbonic anhydrase Enzyme Ki 4.76 CHEMBL

External reference:

IDSource
4017412 VUID
N0000145800 NUI
D00033 KEGG_DRUG
4017412 VANDF
C0070570 UMLSCUI
CHEBI:15882 CHEBI
IPH PDB_CHEM_ID
CHEMBL14060 ChEMBL_ID
DB03255 DRUGBANK_ID
D019800 MESH_DESCRIPTOR_UI
339NCG44TV UNII
996 PUBCHEM_CID
33290 RXNORM
11515 MMSL
5274 MMSL
d05367 MMSL
003172 NDDF
003199 NDDF
116613007 SNOMEDCT_US
354036003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Major Camphor and Phenol HUMAN OTC DRUG LABEL 2 00904-7851 LIQUID 4.70 g TOPICAL OTC monograph final 12 sections
Ulcerease HUMAN OTC DRUG LABEL 1 0316-0100 RINSE 6 mg ORAL OTC monograph not final 10 sections
Sore throatcherry HUMAN OTC DRUG LABEL 1 0363-0376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINULLL 13 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6040 SALVE 0.40 mg TOPICAL OTC monograph not final 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6080 STICK 0.40 mg TOPICAL OTC monograph not final 9 sections
Walgreens Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 0363-9425 GEL 4.70 mg TOPICAL OTC monograph not final 8 sections
Calamine Phenolated Topical Suspension HUMAN OTC DRUG LABEL 2 0395-0407 LOTION 10 mg TOPICAL OTC monograph final 11 sections
Calamine Phenolated Topical Suspension HUMAN OTC DRUG LABEL 2 0395-9109 LOTION 10 mg TOPICAL OTC monograph final 12 sections
RugbyCherry Flavor HUMAN OTC DRUG LABEL 1 0536-1228 SPRAY 1.40 g ORAL OTC monograph not final 13 sections
PhenasepticCherry HUMAN OTC DRUG LABEL 1 0536-2425 LIQUID 1.40 g ORAL OTC MONOGRAPH NOT FINULLL 12 sections
CHAPSTICK MEDICATED HUMAN OTC DRUG LABEL 4 0573-0720 STICK 5 mg TOPICAL OTC monograph not final 13 sections
Sore Throat Cherry HUMAN OTC DRUG LABEL 1 0904-6305 LIQUID 1.50 g ORAL OTC monograph not final 13 sections
Ambix First Aid HUMAN OTC DRUG LABEL 2 10038-250 CREAM 0.01 g TOPICAL OTC monograph not final 11 sections
Blistex Lip Medex HUMAN OTC DRUG LABEL 4 10157-8407 PASTE 0.60 g TOPICAL OTC MONOGRAPH NOT FINULLL 12 sections
Blistex con Medicacion Crema Labial HUMAN OTC DRUG LABEL 2 10157-9926 STICK 0.45 g TOPICAL EXPORT ONLY 1 sections
Blistex Medicated HUMAN OTC DRUG LABEL 4 10157-9951 OINTMENT 0.50 g TOPICAL OTC MONOGRAPH NOT FINULLL 12 sections
Sore throatcherry HUMAN OTC DRUG LABEL 1 11673-376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINULLL 13 sections
Maximum Strength Cold Sore Treatment HUMAN OTC DRUG LABEL 4 11673-412 GEL 15 mg TOPICAL OTC monograph not final 12 sections
Yat Tip Xiao HUMAN OTC DRUG LABEL 2 17429-010 PLASTER 40 mg TOPICAL OTC monograph final 11 sections
Sore Throat HUMAN OTC DRUG LABEL 1 21130-376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINULLL 13 sections
Signature Care Maximum Strength Cold Sore Treatment HUMAN OTC DRUG LABEL 4 21130-418 GEL 15 mg TOPICAL OTC monograph not final 12 sections
Calamine Phenolated Topical Suspension HUMAN OTC DRUG LABEL 2 24385-407 LOTION 10 mg TOPICAL OTC monograph final 12 sections
Budpak First Aid HUMAN OTC DRUG LABEL 2 27293-016 CREAM 0.01 g TOPICAL OTC monograph not final 11 sections
Topcare Cold Sore Treatment HUMAN OTC DRUG LABEL 4 36800-418 GEL 15 mg TOPICAL OTC monograph not final 12 sections
TopCareCherry Flavor HUMAN OTC DRUG LABEL 1 36800-600 SPRAY 1.40 g ORAL OTC monograph not final 13 sections
Topcare Sore ThroatMenthol Flavor HUMAN OTC DRUG LABEL 1 36800-606 SPRAY 1.40 g ORAL OTC monograph not final 13 sections
Shopko Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 37012-734 GEL 4.70 mg TOPICAL OTC monograph final 8 sections
Leader Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 37205-751 GEL 4.70 mg TOPICAL OTC monograph not final 8 sections
HEB Camphor Phenol HUMAN OTC DRUG LABEL 2 37808-105 LIQUID 47 mg TOPICAL OTC monograph not final 11 sections
HEB Sore ThroatCherry Flavor HUMAN OTC DRUG LABEL 1 37808-803 SPRAY 1.40 g ORAL OTC monograph not final 13 sections