ferrous fumarate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4261	141-01-5

Description:

Molecule	Description
Synonyms: ferrous fumarate iron fumarate	used in treatment of iron deficiency anemia; RN given refers to Fe(+2)[1:1] salt Molecular weight: 169.90 Formula: C4H2FeO4 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

ferrous fumarate
iron fumarate

used in treatment of iron deficiency anemia; RN given refers to Fe(+2)[1:1] salt

Molecular weight: 169.90
Formula: C4H2FeO4
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 18, 1986	FDA	GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hand deformity	127.21	10.68	4	57893	159453	63271672
Glossodynia	117.43	10.68	13	57884	178863	63252262
Fall	97.21	10.68	651	57246	391683	63039442
Pericarditis	96.13	10.68	6	57891	131573	63299552
Infusion related reaction	91.93	10.68	55	57842	245466	63185659
Systemic lupus erythematosus	91.46	10.68	38	57859	208880	63222245
Red blood cell count decreased	88.59	10.68	144	57753	40501	63390624
Haematocrit decreased	87.96	10.68	141	57756	39199	63391926
Product use issue	80.32	10.68	51	57846	220469	63210656
Wound	77.64	10.68	26	57871	163237	63267888
Red blood cell sedimentation rate abnormal	77.61	10.68	93	57804	19689	63411436
Haemoglobin decreased	73.64	10.68	295	57602	145190	63285935
Toxicity to various agents	67.02	10.68	76	57821	247174	63183951
Maternal exposure during pregnancy	64.85	10.68	63	57834	219999	63211126
Multiple fractures	63.82	10.68	57	57840	8561	63422564
Helicobacter infection	62.79	10.68	6	57891	92779	63338346
Disability	58.84	10.68	78	57819	18269	63412856
Therapeutic product effect decreased	58.45	10.68	54	57843	193133	63237992
Diarrhoea	58.32	10.68	945	56952	714421	62716704
Drug ineffective	56.96	10.68	645	57252	1044120	62387005
Malignant mediastinal neoplasm	52.84	10.68	26	57871	1420	63429705
Alopecia	51.65	10.68	148	57749	337388	63093737
Discomfort	50.37	10.68	47	57850	167327	63263798
Treatment failure	49.88	10.68	65	57832	198978	63232147
Folliculitis	49.06	10.68	4	57893	70313	63360812
Hepatic enzyme increased	47.76	10.68	69	57828	202259	63228866
Muscle spasms	45.29	10.68	270	57627	155880	63275245
General physical health deterioration	44.35	10.68	72	57825	201330	63229795
Swelling face	43.37	10.68	142	57755	63333	63367792
Product use in unapproved indication	43.32	10.68	60	57837	179020	63252105
Abdominal discomfort	42.56	10.68	150	57747	320735	63110390
Device expulsion	41.81	10.68	96	57801	34826	63396299
Drug intolerance	41.80	10.68	143	57754	308518	63122607
Full blood count decreased	40.98	10.68	80	57817	25944	63405181
Hip fracture	39.77	10.68	85	57812	29389	63401736
Product dose omission issue	38.56	10.68	354	57543	233959	63197166
Blood pressure measurement	37.43	10.68	13	57884	288	63430837
Blister	37.26	10.68	38	57859	129776	63301349
Dizziness	37.17	10.68	574	57323	429351	63001774
Swelling	36.99	10.68	128	57769	275250	63155875
Presbyacusis	36.36	10.68	26	57871	2839	63428286
Sleep disorder due to general medical condition, insomnia type	36.34	10.68	3	57894	52214	63378911
Irritable bowel syndrome	36.01	10.68	15	57882	82397	63348728
Synovitis	33.96	10.68	75	57822	186843	63244282
Fatigue	33.85	10.68	1053	56844	886975	62544150
Device dislocation	33.39	10.68	73	57824	25632	63405493
Psoriasis	33.09	10.68	162	57735	86795	63344330
Unevaluable event	32.49	10.68	112	57785	51274	63379851
Femur fracture	31.81	10.68	97	57800	41659	63389466
Pleural thickening	31.71	10.68	24	57873	2859	63428266
Nasal congestion	31.48	10.68	131	57766	65529	63365596
Intentional product use issue	30.77	10.68	43	57854	127849	63303276
Blood magnesium increased	30.59	10.68	24	57873	3014	63428111
Heart rate	29.85	10.68	8	57889	70	63431055
Blood immunoglobulin E increased	29.58	10.68	26	57871	3823	63427302
Contraindicated product administered	29.33	10.68	101	57796	217547	63213578
Therapy cessation	29.31	10.68	77	57820	30380	63400745
Starvation ketoacidosis	29.08	10.68	8	57889	78	63431047
Intentional overdose	28.58	10.68	16	57881	74136	63356989
Off label use	28.29	10.68	439	57458	674023	62757102
Ill-defined disorder	28.26	10.68	20	57877	81735	63349390
Liver injury	28.13	10.68	10	57887	60510	63370615
Swollen tongue	27.60	10.68	82	57815	34718	63396407
Musculoskeletal pain	26.37	10.68	159	57738	92118	63339007
Pleural fibrosis	25.78	10.68	23	57874	3449	63427676
Large intestine polyp	25.11	10.68	34	57863	8123	63423002
C-reactive protein abnormal	24.52	10.68	95	57802	46001	63385124
Neuropathy peripheral	23.05	10.68	180	57717	113487	63317638
Blood lactic acid	23.01	10.68	7	57890	100	63431025
Cyst	23.00	10.68	44	57853	14055	63417070
Type 2 diabetes mellitus	22.91	10.68	15	57882	63853	63367272
Drug-induced liver injury	22.30	10.68	84	57813	40138	63390987
Metabolic encephalopathy	22.27	10.68	27	57870	5782	63425343
Deep vein thrombosis	21.82	10.68	141	57756	83659	63347466
Full blood count abnormal	20.81	10.68	70	57827	31647	63399478
Pain in extremity	20.54	10.68	420	57477	331066	63100059
Dyspnoea	20.49	10.68	766	57131	660547	62770578
Overdose	20.22	10.68	47	57850	115031	63316094
Dehydration	20.05	10.68	244	57653	173110	63258015
Hyponatraemia	19.89	10.68	172	57725	111728	63319397
Acute kidney injury	19.84	10.68	344	57553	263071	63168054
Lethargy	19.65	10.68	102	57795	55905	63375220
Upper gastrointestinal haemorrhage	19.52	10.68	49	57848	18803	63412322
Hippocampal sclerosis	19.51	10.68	6	57891	89	63431036
Deafness neurosensory	19.33	10.68	23	57874	4832	63426293
Arthropathy	19.31	10.68	130	57767	234662	63196463
Osteopenia	19.02	10.68	50	57847	19735	63411390
Epigastric discomfort	18.99	10.68	27	57870	6753	63424372
Thyroiditis acute	18.92	10.68	6	57891	99	63431026
Parkinsonian rest tremor	18.44	10.68	6	57891	108	63431017
Narrow anterior chamber angle	18.24	10.68	5	57892	48	63431077
Therapeutic product effect incomplete	18.24	10.68	56	57841	125000	63306125
Pain	18.09	10.68	526	57371	740102	62691023
Postural tremor	18.07	10.68	8	57889	343	63430782
Flatulence	18.03	10.68	71	57826	34631	63396494
Dysstasia	17.86	10.68	51	57846	21115	63410010
Blindness cortical	17.85	10.68	9	57888	518	63430607
Exposure during pregnancy	17.84	10.68	77	57820	155470	63275655
Constipation	17.75	10.68	296	57601	224647	63206478
Dry skin	17.53	10.68	100	57797	56787	63374338
Plasma cell myeloma	17.49	10.68	72	57825	35833	63395292
Lower respiratory tract infection	17.40	10.68	62	57835	132245	63298880
Blood potassium increased	17.32	10.68	46	57851	18263	63412862
Suicide attempt	17.28	10.68	18	57879	60900	63370225
Hypertension	17.28	10.68	167	57730	279136	63151989
Cerebellar haematoma	17.17	10.68	8	57889	387	63430738
Pneumonia	17.11	10.68	541	57356	456226	62974899
Pelvic pain	17.11	10.68	38	57859	13481	63417644
Hypophagia	17.10	10.68	65	57832	31194	63399931
Headache	16.93	10.68	722	57175	632519	62798606
Laboratory test abnormal	16.44	10.68	58	57839	26854	63404271
Dysphonia	16.21	10.68	86	57811	47528	63383597
Intentional product misuse	16.18	10.68	19	57878	60898	63370227
Feeling abnormal	15.10	10.68	204	57693	148188	63282937
Skin depigmentation	14.87	10.68	10	57887	989	63430136
Chorea	14.59	10.68	12	57885	1612	63429513
Blood cholesterol increased	14.52	10.68	41	57856	93991	63337134
New onset diabetes after transplantation	14.47	10.68	5	57892	109	63431016
COVID-19	14.22	10.68	54	57843	113049	63318076
Coma	14.16	10.68	23	57874	64341	63366784
Eye swelling	14.14	10.68	51	57846	23867	63407258
Dry eye	14.14	10.68	74	57823	40687	63390438
Drug hypersensitivity	14.08	10.68	199	57698	310488	63120637
Pulmonary embolism	13.82	10.68	165	57732	116519	63314606
Abdominal distension	13.78	10.68	130	57767	86485	63344640
Infected neoplasm	13.76	10.68	6	57891	248	63430877
Periodic limb movement disorder	13.76	10.68	6	57891	248	63430877
Fibromyalgia	13.21	10.68	34	57863	80386	63350739
Ear infection viral	13.13	10.68	5	57892	145	63430980
Dysgeusia	13.03	10.68	80	57817	46630	63384495
Peripheral swelling	13.02	10.68	326	57571	265616	63165509
Megacolon	12.88	10.68	12	57885	1903	63429222
Rhinorrhoea	12.82	10.68	103	57794	65474	63365651
Back pain	12.69	10.68	323	57574	263822	63167303
Myotonia	12.67	10.68	5	57892	160	63430965
Pulmonary arterial hypertension	12.39	10.68	47	57850	22530	63408595
Blood potassium decreased	12.37	10.68	73	57824	41953	63389172
Infection	12.15	10.68	142	57755	229031	63202094
Eye pain	12.11	10.68	62	57835	33792	63397333
Tremor	11.93	10.68	178	57719	132061	63299064
Cough	11.81	10.68	350	57547	292393	63138732
Cardio-respiratory arrest	11.77	10.68	23	57874	59936	63371189
Osteoporosis	11.72	10.68	91	57806	57247	63373878
Atrial fibrillation	11.72	10.68	160	57737	116476	63314649
Oedema peripheral	11.67	10.68	240	57657	189271	63241854
Hepatotoxicity	11.61	10.68	10	57887	37031	63394094
Hypoaesthesia oral	11.58	10.68	32	57865	13001	63418124
Nausea	11.52	10.68	916	56981	853555	62577570
Drug interaction	11.38	10.68	144	57753	228987	63202138
Fluid retention	11.26	10.68	93	57804	59593	63371532
Respiratory arrest	11.26	10.68	8	57889	32637	63398488
Intracranial haematoma	11.03	10.68	6	57891	404	63430721
Initial insomnia	11.02	10.68	20	57877	6137	63424988
Hepatobiliary infection	11.02	10.68	3	57894	28	63431097
Temporal lobe epilepsy	11.01	10.68	6	57891	405	63430720
Reperfusion arrhythmia	10.78	10.68	5	57892	239	63430886
Bone pain	10.78	10.68	86	57811	54555	63376570
Pain of skin	10.77	10.68	29	57868	11605	63419520
Uterine leiomyoma	10.69	10.68	25	57872	9173	63421952

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Clear cell renal cell carcinoma	80.69	11.21	32	29693	1115	34926091
Fall	65.04	11.21	342	29383	202543	34724663
Completed suicide	61.78	11.21	6	29719	98162	34829044
Lymphoproliferative disorder	59.27	11.21	34	29691	2725	34924481
Toxicity to various agents	56.90	11.21	52	29673	200310	34726896
Fatigue	43.73	11.21	494	29231	370159	34557047
Off label use	41.42	11.21	200	29525	419324	34507882
Plasma cell myeloma	40.77	11.21	102	29623	41935	34885271
Product use in unapproved indication	36.38	11.21	28	29697	117471	34809735
Full blood count decreased	35.73	11.21	59	29666	18029	34909177
Diarrhoea	35.39	11.21	495	29230	389417	34537789
Product dose omission issue	31.13	11.21	191	29534	119520	34807686
Drug ineffective	29.93	11.21	247	29478	456504	34470702
Asthenia	29.33	11.21	328	29397	244923	34682283
Psoriasis	28.46	11.21	85	29640	38727	34888479
Autoscopy	28.45	11.21	10	29715	247	34926959
Congenital oesophageal anomaly	28.36	11.21	8	29717	93	34927113
Drug interaction	27.63	11.21	99	29626	225847	34701359
Laboratory test abnormal	27.02	11.21	56	29669	20335	34906871
Intentional product misuse	25.72	11.21	4	29721	45607	34881599
Meconium abnormal	25.33	11.21	7	29718	75	34927131
General physical health deterioration	24.30	11.21	45	29680	128224	34798982
White blood cell count decreased	23.99	11.21	151	29574	95294	34831912
Viral infection	21.73	11.21	47	29678	17576	34909630
Polyhydramnios	21.39	11.21	8	29717	237	34926969
Adverse drug reaction	21.26	11.21	64	29661	29278	34897928
Abdominal symptom	21.25	11.21	10	29715	531	34926675
Multiple organ dysfunction syndrome	20.38	11.21	21	29704	76545	34850661
Apnoeic attack	20.28	11.21	9	29716	417	34926789
Intentional overdose	20.22	11.21	6	29719	43668	34883538
Confusional state	20.10	11.21	199	29526	143961	34783245
Paraneoplastic rash	19.99	11.21	6	29719	88	34927118
High frequency ablation	19.76	11.21	7	29718	177	34927029
Pneumonia	17.73	11.21	418	29307	362209	34564997
Necrotising enterocolitis neonatal	17.70	11.21	7	29718	242	34926964
Dizziness	17.20	11.21	271	29454	218250	34708956
Suicide attempt	17.00	11.21	6	29719	39110	34888096
Influenza	16.72	11.21	85	29640	49581	34877625
Hepatic function abnormal	15.84	11.21	9	29716	44354	34882852
Lymphoedema	15.39	11.21	18	29707	3985	34923221
Epileptic encephalopathy	15.32	11.21	6	29719	202	34927004
Interstitial lung disease	15.12	11.21	20	29705	65262	34861944
Microcytic anaemia	15.00	11.21	14	29711	2386	34924820
Dependence on oxygen therapy	14.97	11.21	6	29719	215	34926991
Muscle spasms	14.89	11.21	112	29613	74889	34852317
Treatment failure	14.60	11.21	11	29714	46686	34880520
Spinal epidural haemorrhage	14.55	11.21	4	29721	42	34927164
Peripheral swelling	14.47	11.21	113	29612	76428	34850778
Agitated depression	14.14	11.21	6	29719	249	34926957
COVID-19	13.98	11.21	28	29697	77522	34849684
Hip fracture	13.79	11.21	31	29694	11894	34915312
Gastrointestinal haemorrhage	13.74	11.21	125	29600	88352	34838854
Swelling face	13.65	11.21	47	29678	23058	34904148
Small intestinal obstruction	13.29	11.21	35	29690	14831	34912375
Femoral neck fracture	12.93	11.21	15	29710	3292	34923914
Abdominal pain	12.89	11.21	203	29522	163415	34763791
Weight decreased	12.88	11.21	216	29509	176085	34751121
Bone abscess	12.12	11.21	5	29720	193	34927013
Cardiac flutter	11.95	11.21	11	29714	1842	34925364
Rash	11.85	11.21	260	29465	222492	34704714
Cytomegalovirus infection	11.37	11.21	4	29721	26131	34901075
Product use issue	11.25	11.21	23	29702	63193	34864013

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	193.13	9.90	7	72697	245760	79425924
Fall	143.36	9.90	845	71859	486784	79184900
Toxicity to various agents	123.96	9.90	121	72583	421419	79250265
Haematocrit decreased	90.04	9.90	183	72521	61129	79610555
Red blood cell count decreased	82.49	9.90	170	72534	57343	79614341
Hand deformity	78.14	9.90	4	72700	103915	79567769
Multiple fractures	71.49	9.90	59	72645	7967	79663717
Infusion related reaction	68.86	9.90	65	72639	230172	79441512
Haemoglobin decreased	68.34	9.90	390	72314	221729	79449955
Red blood cell sedimentation rate abnormal	67.06	9.90	89	72615	20874	79650810
Product use in unapproved indication	64.53	9.90	80	72624	250279	79421405
Clear cell renal cell carcinoma	61.91	9.90	35	72669	2541	79669143
Drug ineffective	59.23	9.90	666	72038	1080247	78591437
General physical health deterioration	59.09	9.90	100	72604	275138	79396546
Disability	58.36	9.90	75	72629	17045	79654639
Product use issue	56.24	9.90	65	72639	209757	79461927
Device expulsion	54.16	9.90	90	72614	25771	79645913
Glossodynia	53.57	9.90	14	72690	103323	79568361
Malignant mediastinal neoplasm	53.38	9.90	26	72678	1389	79670295
Dizziness	53.17	9.90	722	71982	525719	79145965
Swelling face	52.04	9.90	163	72541	71049	79600635
Off label use	51.60	9.90	554	72150	906661	78765023
Hip fracture	48.98	9.90	95	72609	30666	79641018
Diarrhoea	47.68	9.90	1093	71611	879396	78792288
Intentional product misuse	47.26	9.90	14	72690	95151	79576533
Fatigue	46.35	9.90	1141	71563	928586	78743098
Product dose omission issue	45.96	9.90	384	72320	247153	79424531
Duodenal ulcer perforation	45.53	9.90	4	72700	66207	79605477
Drug interaction	42.67	9.90	214	72490	414969	79256715
Intentional overdose	42.09	9.90	22	72682	105938	79565746
Femur fracture	41.68	9.90	102	72602	38550	79633134
Lymphoproliferative disorder	41.31	9.90	37	72667	5578	79666106
Helicobacter infection	41.13	9.90	7	72697	69697	79601987
Pericarditis	40.88	9.90	22	72682	104214	79567470
Full blood count decreased	38.12	9.90	79	72625	26740	79644944
Plasma cell myeloma	38.07	9.90	121	72583	53138	79618546
Blood immunoglobulin E increased	36.03	9.90	35	72669	5847	79665837
Treatment failure	35.60	9.90	63	72641	170423	79501261
Systemic lupus erythematosus	35.27	9.90	35	72669	121114	79550570
Overdose	35.03	9.90	72	72632	184134	79487550
Muscle spasms	34.54	9.90	275	72429	174455	79497229
Hepatic enzyme increased	34.20	9.90	72	72632	182538	79489146
Upper gastrointestinal haemorrhage	33.30	9.90	98	72606	41282	79630402
Musculoskeletal pain	32.95	9.90	182	72522	102172	79569512
Blood pressure measurement	32.25	9.90	13	72691	440	79671244
Therapy cessation	32.20	9.90	91	72613	37471	79634213
Folliculitis	31.72	9.90	6	72698	55374	79616310
Therapeutic product effect decreased	29.53	9.90	66	72638	163797	79507887
Sleep disorder due to general medical condition, insomnia type	28.97	9.90	3	72701	43553	79628131
Presbyacusis	28.94	9.90	22	72682	2638	79669046
Drug intolerance	28.93	9.90	133	72571	263986	79407698
Swollen tongue	28.87	9.90	95	72609	42475	79629209
Confusional state	28.77	9.90	428	72276	317569	79354115
Device dislocation	28.49	9.90	69	72635	25901	79645783
Nasal congestion	27.98	9.90	141	72563	76411	79595273
Metabolic encephalopathy	27.98	9.90	38	72666	9109	79662575
Irritable bowel syndrome	27.71	9.90	11	72693	62230	79609454
COVID-19	27.21	9.90	65	72639	157609	79514075
Heart rate	26.85	9.90	8	72696	106	79671578
Dyspnoea	26.69	9.90	993	71711	856032	78815652
Suicide attempt	25.26	9.90	23	72681	82909	79588775
Dehydration	25.22	9.90	341	72363	247846	79423838
Starvation ketoacidosis	24.80	9.90	8	72696	140	79671544
Pleural thickening	24.65	9.90	21	72683	2961	79668723
Intentional product use issue	24.46	9.90	65	72639	152047	79519637
Wound	24.19	9.90	43	72661	116136	79555548
Blister	24.18	9.90	45	72659	119431	79552253
Discomfort	23.96	9.90	49	72655	125568	79546116
Blood magnesium increased	23.64	9.90	22	72682	3484	79668200
Cytomegalovirus infection	23.63	9.90	5	72699	42639	79629045
Maternal exposure during pregnancy	22.99	9.90	57	72647	136481	79535203
Asthenia	22.74	9.90	619	72085	511070	79160614
Coma	22.10	9.90	36	72668	100613	79571071
Deep vein thrombosis	22.10	9.90	187	72517	120732	79550952
Alopecia	21.64	9.90	123	72581	231232	79440452
Hypophagia	21.35	9.90	90	72614	45277	79626407
Drug resistance	21.34	9.90	6	72698	42207	79629477
Peripheral swelling	21.01	9.90	354	72350	269263	79402421
Ill-defined disorder	20.38	9.90	18	72686	65857	79605827
Pain in extremity	20.06	9.90	454	72250	364084	79307600
Hyponatraemia	19.58	9.90	248	72456	177600	79494084
Paraneoplastic rash	19.58	9.90	6	72698	88	79671596
Lethargy	19.50	9.90	134	72570	81158	79590526
Cardio-respiratory arrest	19.30	9.90	44	72660	108466	79563218
Hepatic function abnormal	19.19	9.90	23	72681	73084	79598600
Hypervolaemia	18.79	9.90	83	72621	42607	79629077
Large intestine polyp	18.73	9.90	38	72666	12670	79659014
Fluid retention	18.51	9.90	118	72586	69691	79601993
C-reactive protein abnormal	18.32	9.90	90	72614	48277	79623407
Pneumonia	18.15	9.90	755	71949	659491	79012193
Multiple organ dysfunction syndrome	18.13	9.90	53	72651	120193	79551491
Abdominal pain	18.07	9.90	474	72230	389095	79282589
Blood potassium increased	17.81	9.90	63	72641	29212	79642472
Therapeutic response decreased	17.59	9.90	21	72683	66832	79604852
Pelvic pain	17.38	9.90	38	72666	13343	79658341
Acute kidney injury	17.38	9.90	607	72097	518797	79152887
Dysgeusia	17.29	9.90	100	72604	57077	79614607
Clostridium test positive	17.05	9.90	25	72679	6429	79665255
Synovitis	17.03	9.90	75	72629	150659	79521025
Pleural fibrosis	17.02	9.90	20	72684	4147	79667537
Eye swelling	17.00	9.90	58	72646	26410	79645274
Liver injury	16.89	9.90	16	72688	56598	79615086
Interstitial lung disease	16.71	9.90	50	72654	112550	79559134
Hospice care	16.57	9.90	32	72672	10292	79661392
Therapeutic product effect incomplete	16.30	9.90	70	72634	141575	79530109
New onset diabetes after transplantation	16.09	9.90	6	72698	164	79671520
High frequency ablation	15.90	9.90	7	72697	296	79671388
Epigastric discomfort	15.89	9.90	27	72677	7869	79663815
Apnoeic attack	15.77	9.90	9	72695	665	79671019
Oedema peripheral	15.73	9.90	320	72384	251968	79419716
Headache	15.63	9.90	737	71967	653035	79018649
Faeces discoloured	15.47	9.90	60	72644	29067	79642617
Cyst	15.43	9.90	37	72667	13803	79657881
Gastrointestinal haemorrhage	15.42	9.90	204	72500	147515	79524169
Hypertension	15.33	9.90	211	72493	330781	79340903
Hepatobiliary infection	15.03	9.90	4	72700	34	79671650
Cytokine release syndrome	15.01	9.90	7	72697	35991	79635693
Acute respiratory distress syndrome	14.93	9.90	11	72693	44056	79627628
Unevaluable event	14.77	9.90	94	72610	55491	79616193
Pulmonary arterial hypertension	14.71	9.90	58	72646	28308	79643376
Right aortic arch	14.71	9.90	3	72701	6	79671678
Abdominal symptom	14.63	9.90	9	72695	764	79670920
Psoriasis	14.53	9.90	135	72569	89452	79582232
Respiratory arrest	14.18	9.90	19	72685	57531	79614153
Neurotoxicity	14.07	9.90	6	72698	32512	79639172
Sedation	13.97	9.90	16	72688	51879	79619805
Dysstasia	13.81	9.90	56	72648	27690	79643994
Eye pain	13.58	9.90	69	72635	37509	79634175
Cerebellar haematoma	13.58	9.90	8	72696	628	79671056
Gingival erosion	13.54	9.90	5	72699	133	79671551
Dyspnoea exertional	13.52	9.90	130	72574	86943	79584741
Cardiogenic shock	13.52	9.90	11	72693	41903	79629781
Accidental exposure to product	13.20	9.90	6	72698	31316	79640368
Blood potassium decreased	13.20	9.90	80	72624	46432	79625252
Parkinsonian rest tremor	13.18	9.90	6	72698	275	79671409
Flatulence	13.10	9.90	75	72629	42649	79629035
Blood lactic acid	13.08	9.90	7	72697	456	79671228
Transfusion	13.06	9.90	46	72658	21284	79650400
Product prescribing error	12.98	9.90	13	72691	44800	79626884
Gastric antral vascular ectasia	12.87	9.90	9	72695	949	79670735
Viral infection	12.85	9.90	75	72629	42941	79628743
Small intestinal obstruction	12.75	9.90	54	72650	27218	79644466
Blindness cortical	12.63	9.90	9	72695	978	79670706
Ear infection viral	12.52	9.90	5	72699	165	79671519
Tremor	12.40	9.90	221	72483	169862	79501822
Application site erythema	12.37	9.90	19	72685	5091	79666593
Altered state of consciousness	12.36	9.90	13	72691	43809	79627875
Osteoporosis	12.27	9.90	88	72616	54024	79617660
Postural tremor	12.25	9.90	8	72696	754	79670930
Narrow anterior chamber angle	12.19	9.90	5	72699	177	79671507
Respiratory depression	12.11	9.90	5	72699	27625	79644059
Disseminated intravascular coagulation	12.08	9.90	9	72695	35833	79635851
Cholestasis	12.05	9.90	18	72686	52091	79619593
Polyhydramnios	12.00	9.90	11	72693	1709	79669975
Illness	11.82	9.90	15	72689	46496	79625188
Dependence on oxygen therapy	11.82	9.90	7	72697	555	79671129
Neoplasm progression	11.80	9.90	18	72686	51664	79620020
Uterine leiomyoma	11.63	9.90	21	72683	6422	79665262
Hepatotoxicity	11.62	9.90	18	72686	51334	79620350
Influenza like illness	11.60	9.90	108	72596	71599	79600085
Osteopenia	11.58	9.90	40	72664	18324	79653360
Back pain	11.57	9.90	361	72343	303819	79367865
Fibromyalgia	11.51	9.90	26	72678	64314	79607370
Infected neoplasm	11.50	9.90	6	72698	371	79671313
Mental status changes	11.42	9.90	102	72602	66857	79604827
Rash	11.36	9.90	640	72064	577718	79093966
Stress	11.35	9.90	36	72668	79576	79592108
Renal cell carcinoma	11.32	9.90	21	72683	6557	79665127
Feeling abnormal	11.30	9.90	206	72498	158993	79512691
Abdominal distension	11.17	9.90	162	72542	119488	79552196
Rash pruritic	11.15	9.90	107	72597	71522	79600162
Bone pain	11.15	9.90	88	72616	55654	79616030
Intentional self-injury	11.11	9.90	8	72696	32411	79639273
Melaena	11.03	9.90	94	72610	60796	79610888
Complication associated with device	10.94	9.90	38	72666	17458	79654226
Hypoaesthesia oral	10.94	9.90	33	72671	14091	79657593
Myotonia	10.81	9.90	5	72699	238	79671446
Malignant neoplasm progression	10.80	9.90	76	72628	135914	79535770
Ventricular fibrillation	10.78	9.90	8	72696	31918	79639766
Agitated depression	10.75	9.90	6	72698	425	79671259
Stomatitis	10.71	9.90	84	72620	146673	79525011
Hospitalisation	10.62	9.90	132	72572	94104	79577580
Cardiac arrest	10.57	9.90	103	72601	171993	79499691
International normalised ratio increased	10.57	9.90	121	72583	84600	79587084
Chorea	10.54	9.90	12	72692	2405	79669279
Depressed level of consciousness	10.37	9.90	49	72655	96603	79575081
Pulmonary embolism	10.13	9.90	216	72488	171438	79500246
Rhabdomyolysis	10.09	9.90	54	72650	103077	79568607
Cardiac flutter	10.05	9.90	17	72687	4937	79666747
Vaginal haemorrhage	10.05	9.90	43	72661	21774	79649910
Application site rash	10.01	9.90	11	72693	2121	79669563
Epileptic encephalopathy	9.97	9.90	6	72698	490	79671194

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03AA02	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron bivalent, oral preparations
ATC	B03AD02	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in combination with folic acid
MeSH PA	D018977	Micronutrients
MeSH PA	D014131	Trace Elements

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Contraception	indication	13197004
Anemia of prematurity	indication	47100003	DOID:11243
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Iron deficiency anemia	indication	87522002
Acne vulgaris	indication	88616000
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Amenorrhea	off-label use	14302001	DOID:13938
Female hypogonadism syndrome	off-label use	16041008
Polycystic ovaries	off-label use	69878008
Endometriosis	off-label use	129103003
Dysmenorrhea	off-label use	266599000
Abnormal uterine bleeding unrelated to menstrual cycle	off-label use	312984006
Menorrhagia	off-label use	386692008
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use
Heart valve disorder	contraindication	368009	DOID:4079
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Constipation	contraindication	14760008	DOID:2089
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Myocardial infarction	contraindication	22298006	DOID:5844
Gastroenteritis	contraindication	25374005	DOID:2326
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Depressive disorder	contraindication	35489007
Migraine	contraindication	37796009	DOID:6364
Hypertensive disorder	contraindication	38341003	DOID:10763
Hemosiderosis	contraindication	39011001	DOID:12119
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypokalemia	contraindication	43339004
Body fluid retention	contraindication	43498006
Thrombosis of retinal vein	contraindication	46085004
Gastrectomy	contraindication	53442002
Hyperlipidemia	contraindication	55822004	DOID:1168
Benign mammary dysplasia	contraindication	57993004
Leber's optic atrophy	contraindication	58610003	DOID:705
Obstructive hyperbilirubinemia	contraindication	59848001
Hemolytic anemia	contraindication	61261009	DOID:583
Thrombophlebitis	contraindication	64156001	DOID:3875
Ulcerative colitis	contraindication	64766004	DOID:8577
Intermenstrual bleeding - irregular	contraindication	64996003
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Atrophic gastritis	contraindication	84568007	DOID:8929
Kidney disease	contraindication	90708001	DOID:557
Malignant neoplasm of liver	contraindication	93870000	DOID:3571
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Deep venous thrombosis	contraindication	128053003
Liver function tests abnormal	contraindication	166603001
Angina pectoris	contraindication	194828000
Osteolysis	contraindication	203522001
Cerebrovascular accident	contraindication	230690007
Pulmonary thromboembolism	contraindication	233935004
Disease of liver	contraindication	235856003	DOID:409
Cholestasis of pregnancy	contraindication	235888006
Endometrial carcinoma	contraindication	254878006	DOID:2871
Hypertriglyceridemia	contraindication	302870006
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Malignant tumor of cervix	contraindication	363354003	DOID:4362
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Disorder of coronary artery	contraindication	414024009
Obesity	contraindication	414916001	DOID:9970
Estrogen receptor positive tumor	contraindication	416053008
Porphyria	contraindication	418470004
Hypertensive urgency	contraindication	443482000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Nonspecific Abnormal Papanicolaou Smear of Cervix	contraindication
Repeated Blood Transfusions	contraindication
Major Surgery with Prolonged Post-Operative Immobilization	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017694	VUID
N0000146068	NUI
D01194	KEGG_DRUG
4017630	VANDF
4017694	VANDF
4028811	VANDF
C0060276	UMLSCUI
CHEBI:31607	CHEBI
CHEMBL1200640	ChEMBL_ID
DB14491	DRUGBANK_ID
C031621	MESH_SUPPLEMENTAL_RECORD_UI
R5L488RY0Q	UNII
6433164	PUBCHEM_CID
24941	RXNORM
4723	MMSL
4919	MMSL
6955	MMSL
d03920	MMSL
000833	NDDF
387289009	SNOMEDCT_US
52108005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	2 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	2 mg	ORAL	unapproved drug other	10 sections
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	27 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
O-Cal Prenatal Vitamin	HUMAN PRESCRIPTION DRUG LABEL	16	0813-0202	TABLET	15 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	10544-549	TABLET, FILM COATED	27 mg	ORAL	unapproved drug other	8 sections
Se-Natal 19	HUMAN PRESCRIPTION DRUG LABEL	15	13925-116	TABLET	29 mg	ORAL	unapproved drug other	15 sections
Se-Natal 19	HUMAN PRESCRIPTION DRUG LABEL	15	13925-116	TABLET	29 mg	ORAL	unapproved drug other	15 sections
Se-Natal 19 Chewable	HUMAN PRESCRIPTION DRUG LABEL	14	13925-117	TABLET, CHEWABLE	29 mg	ORAL	unapproved drug other	16 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	162 mg	ORAL	unapproved drug other	19 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	162 mg	ORAL	unapproved drug other	19 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	15338-522	TABLET, FILM COATED	27 mg	ORAL	unapproved drug other	8 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	17856-0668	TABLET, FILM COATED	27 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
C-Nate DHA	HUMAN PRESCRIPTION DRUG LABEL	13	23359-105	CAPSULE, GELATIN COATED	28 mg	ORAL	unapproved drug other	15 sections
Prenatal Plus Vitamins	HUMAN PRESCRIPTION DRUG LABEL	15	39328-106	TABLET	27 mg	ORAL	UNAPPROVED DRUG OTHER	7 sections
PNV-Select	HUMAN PRESCRIPTION DRUG LABEL	18	42192-320	TABLET, FILM COATED	27 mg	ORAL	unapproved drug other	10 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	10	42192-321	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	11 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	8	42192-323	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	11 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	28 mg	ORAL	unapproved drug other	12 sections
Prenaissance	HUMAN PRESCRIPTION DRUG LABEL	9	42192-341	CAPSULE, LIQUID FILLED	29 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	42291-686	TABLET, FILM COATED	27 mg	ORAL	unapproved drug other	8 sections
PNV Prenatal VitaminPlus Vitamin A	HUMAN PRESCRIPTION DRUG LABEL	12	44946-1046	TABLET	27 mg	ORAL	UNAPPROVED DRUG OTHER	9 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	50090-0617	TABLET	27 mg	ORAL	Unapproved drug other	9 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	50268-677	TABLET, FILM COATED	27 mg	ORAL	unapproved drug other	8 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	130 mg	ORAL	unapproved drug other	13 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	42.50 mg	ORAL	unapproved drug other	13 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	17.50 mg	ORAL	unapproved drug other	7 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	53.50 mg	ORAL	unapproved drug other	7 sections
Integra F	HUMAN PRESCRIPTION DRUG LABEL	5	52747-711	CAPSULE	62.50 mg	ORAL	unapproved drug other	14 sections
Integra F	HUMAN PRESCRIPTION DRUG LABEL	5	52747-711	CAPSULE	191.20 mg	ORAL	unapproved drug other	14 sections
Integra Plus	HUMAN PRESCRIPTION DRUG LABEL	10	52747-712	CAPSULE	62.50 mg	ORAL	unapproved drug other	12 sections