bismuth subsalicylate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4257 14882-18-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bismuth subsalicylate
  • bismogenol
  • bismuth oxysalicylate
bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter
  • Molecular weight: 362.09
  • Formula: C7H5BiO4
  • CLOGP: 0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.76
  • ALOGS: -0.78
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 15, 1996 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA Chemical/Ingredient N0000007888 Bismuth
MeSH PA D000930 Antidiarrheals
MeSH PA D005765 Gastrointestinal Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diarrhea indication 62315008
Indigestion indication 162031009
Duodenal Ulcer due to H. Pylori indication
Traveler's diarrhea off-label use 11840006
Helicobacter pylori-associated gastritis off-label use 708164002
Helicobacter Pylori Gastritis off-label use
Alcoholism contraindication 7200002
Lowered convulsive threshold contraindication 19260006
Alcohol intoxication contraindication 25702006
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Disorder of brain contraindication 81308009 DOID:936
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018971 VUID
N0000147252 NUI
C0053792 UMLSCUI
D00728 KEGG_DRUG
62TEY51RR1 UNII
409307004 SNOMEDCT_US
4018971 VANDF
001159 NDDF
d01026 MMSL
4290 MMSL
19478 RXNORM
82075003 SNOMEDCT_US
CHEMBL1120 ChEMBL_ID
DB01294 DRUGBANK_ID
CHEBI:261649 CHEBI
16682734 PUBCHEM_CID
C015715 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense stomach relief HUMAN OTC DRUG LABEL 1 0113-0469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 9 sections
basic care stomach relief HUMAN OTC DRUG LABEL 1 0113-7469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 9 sections
Pink Bismuth HUMAN OTC DRUG LABEL 1 0121-4803 SUSPENSION 262 mg ORAL OTC monograph final 10 sections
Percy Medicine HUMAN OTC DRUG LABEL 1 0322-2222 LIQUID 1050 mg ORAL OTC monograph final 8 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0025 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0073 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0319 TABLET, CHEWABLE 262 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0346 TABLET 262 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0371 LIQUID 1050 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0736 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-7240 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-7370 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9124 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9125 TABLET, FILM COATED 262 mg ORAL OTC monograph final 16 sections
Peptic Relief HUMAN OTC DRUG LABEL 1 0536-1021 TABLET 262 mg ORAL OTC MONOGRAPH FINAL 9 sections
Stomach Relief HUMAN OTC DRUG LABEL 1 0536-1286 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
Stomach Relief HUMAN OTC DRUG LABEL 1 0536-1287 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
PINK BISMUTH HUMAN OTC DRUG LABEL 1 0536-1810 LIQUID 262 mg ORAL OTC monograph final 8 sections
Bismatrol HUMAN OTC DRUG LABEL 1 0904-1313 LIQUID 262 mg ORAL OTC monograph final 8 sections
Bismatrol HUMAN OTC DRUG LABEL 1 0904-1314 LIQUID 525 mg ORAL OTC monograph final 8 sections
Bismatrol HUMAN OTC DRUG LABEL 1 0904-1315 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 8 sections
KAO-TIN PEPPERMINT FLAVOR HUMAN OTC DRUG LABEL 1 0904-5709 LIQUID 262 mg ORAL OTC monograph final 8 sections
Kola-Pectin HUMAN OTC DRUG LABEL 1 11026-2639 LIQUID 525 mg ORAL OTC monograph final 10 sections
up and up 5-symptom digestive relief HUMAN OTC DRUG LABEL 1 11673-122 TABLET 262 mg ORAL OTC monograph final 8 sections
up and up 5-symptom digestive relief HUMAN OTC DRUG LABEL 1 11673-125 TABLET 262 mg ORAL OTC monograph final 8 sections
Digestive Relief HUMAN OTC DRUG LABEL 1 11673-372 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
up and up digestive relief HUMAN OTC DRUG LABEL 1 11673-706 SUSPENSION 525 mg ORAL OTC monograph final 9 sections
Digestive Relief HUMAN OTC DRUG LABEL 1 11673-724 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections
ULTRA STRENGHT PINK BISMUTH HUMAN OTC DRUG LABEL 1 11673-907 SUSPENSION 525 mg ORAL OTC monograph final 9 sections
Stomach Relief HUMAN OTC DRUG LABEL 1 11822-0273 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 9 sections