bismuth subsalicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4257 14882-18-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bismuth subsalicylate
  • bismogenol
  • bismuth oxysalicylate
bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter
  • Molecular weight: 362.09
  • Formula: C7H5BiO4
  • CLOGP: 0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.76
  • ALOGS: -0.78
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 15, 1996 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 106.43 21.38 50 2890 39721 50562463
Diarrhoea 63.59 21.38 118 2822 588358 50013826
Cholecystitis chronic 52.08 21.38 20 2920 9649 50592535
End stage renal disease 34.99 21.38 13 2927 5724 50596460
Renal injury 29.88 21.38 13 2927 8598 50593586
Cholelithiasis 26.35 21.38 20 2920 37953 50564231
Eyelid pain 23.94 21.38 5 2935 260 50601924
Faeces discoloured 22.16 21.38 13 2927 16111 50586073

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 118.49 24.97 49 1324 36367 29536787
End stage renal disease 41.56 24.97 15 1358 7649 29565505
Diarrhoea 40.42 24.97 62 1311 332636 29240518

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic kidney disease 145.07 20.40 68 3418 57851 64437395
Diarrhoea 55.86 20.40 121 3365 722583 63772663
End stage renal disease 48.37 20.40 19 3467 10456 64484790
Cholecystitis chronic 46.98 20.40 18 3468 9269 64485977
Renal injury 26.35 20.40 14 3472 15415 64479831
Eyelid pain 24.04 20.40 5 3481 274 64494972
Nephrogenic anaemia 22.56 20.40 8 3478 3317 64491929
Vomiting 22.50 20.40 73 3413 551044 63944202
Cholelithiasis 22.34 20.40 19 3467 45487 64449759
Abdominal pain upper 21.67 20.40 36 3450 174994 64320252
Tongue pruritus 21.25 20.40 5 3481 483 64494763
Gastrooesophageal reflux disease 20.76 20.40 24 3462 83119 64412127

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0002611 Bismuth
MeSH PA D000930 Antidiarrheals
MeSH PA D005765 Gastrointestinal Agents
FDA EPC N0000180183 Bismuth

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diarrhea indication 62315008
Indigestion indication 162031009
Duodenal Ulcer due to H. Pylori indication
Traveler's diarrhea off-label use 11840006
Helicobacter pylori-associated gastritis off-label use 708164002
Helicobacter Pylori Gastritis off-label use
Alcoholism contraindication 7200002
Lowered convulsive threshold contraindication 19260006
Alcohol intoxication contraindication 25702006
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Disorder of brain contraindication 81308009 DOID:936
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018971 VUID
N0000147252 NUI
D00728 KEGG_DRUG
4018971 VANDF
C0053792 UMLSCUI
CHEBI:261649 CHEBI
CHEMBL1120 ChEMBL_ID
DB01294 DRUGBANK_ID
C015715 MESH_SUPPLEMENTAL_RECORD_UI
62TEY51RR1 UNII
16682734 PUBCHEM_CID
19478 RXNORM
4290 MMSL
d01026 MMSL
001159 NDDF
409307004 SNOMEDCT_US
82075003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense stomach relief HUMAN OTC DRUG LABEL 1 0113-0469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
good sense stomach relief HUMAN OTC DRUG LABEL 1 0113-0469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
basic care stomach relief HUMAN OTC DRUG LABEL 1 0113-7469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
basic care stomach relief HUMAN OTC DRUG LABEL 1 0113-7469 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
Stomach Relief HUMAN OTC DRUG LABEL 1 0121-0910 LIQUID 525 mg ORAL OTC monograph final 16 sections
Stomach Relief HUMAN OTC DRUG LABEL 1 0121-0910 LIQUID 525 mg ORAL OTC monograph final 16 sections
Pink Bismuth HUMAN OTC DRUG LABEL 1 0121-4803 SUSPENSION 262 mg ORAL OTC monograph final 17 sections
Percy Medicine HUMAN OTC DRUG LABEL 1 0322-2222 LIQUID 1050 mg ORAL OTC monograph final 8 sections
Percy Medicine HUMAN OTC DRUG LABEL 1 0322-2222 LIQUID 1050 mg ORAL OTC monograph final 8 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0025 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0025 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0073 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0073 LIQUID 525 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0319 TABLET, CHEWABLE 262 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0319 TABLET, CHEWABLE 262 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0346 TABLET 262 mg ORAL OTC monograph final 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0346 TABLET 262 mg ORAL OTC monograph final 16 sections
SootheMaximum Strength HUMAN OTC DRUG LABEL 1 0363-0371 LIQUID 1050 mg ORAL OTC MONOGRAPH FINAL 16 sections
SootheMaximum Strength HUMAN OTC DRUG LABEL 1 0363-0371 LIQUID 1050 mg ORAL OTC MONOGRAPH FINAL 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0736 LIQUID 525 mg ORAL OTC monograph final 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-0736 LIQUID 525 mg ORAL OTC monograph final 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-7240 LIQUID 525 mg ORAL OTC monograph final 16 sections
Soothe HUMAN OTC DRUG LABEL 1 0363-7240 LIQUID 525 mg ORAL OTC monograph final 16 sections
SootheUltra Strength HUMAN OTC DRUG LABEL 1 0363-7370 LIQUID 525 mg ORAL OTC monograph final 16 sections
SootheUltra Strength HUMAN OTC DRUG LABEL 1 0363-7370 LIQUID 525 mg ORAL OTC monograph final 16 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9124 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9124 TABLET, CHEWABLE 262 mg ORAL OTC monograph final 16 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9125 TABLET, FILM COATED 262 mg ORAL OTC monograph final 16 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-9125 TABLET, FILM COATED 262 mg ORAL OTC monograph final 16 sections
Peptic Relief HUMAN OTC DRUG LABEL 1 0536-1021 TABLET 262 mg ORAL OTC MONOGRAPH FINAL 15 sections