bismuth subsalicylate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4257 | 14882-18-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 15, 1996 | FDA | PROMETHEUS LABS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA Chemical/Ingredient | N0000007888 | Bismuth |
| MeSH PA | D000930 | Antidiarrheals |
| MeSH PA | D005765 | Gastrointestinal Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diarrhea | indication | 62315008 | |
| Indigestion | indication | 162031009 | |
| Duodenal Ulcer due to H. Pylori | indication | ||
| Traveler's diarrhea | off-label use | 11840006 | |
| Helicobacter pylori-associated gastritis | off-label use | 708164002 | |
| Helicobacter Pylori Gastritis | off-label use | ||
| Alcoholism | contraindication | 7200002 | |
| Lowered convulsive threshold | contraindication | 19260006 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Hepatic failure | contraindication | 59927004 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Disorder of brain | contraindication | 81308009 | DOID:936 |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 | |
| Non-infective meningitis | contraindication | 230155003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Peripheral nerve disease | contraindication | 302226006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Breastfeeding (mother) | contraindication | 413712001 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cyclooxygenase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018971 | VUID |
| N0000147252 | NUI |
| C0053792 | UMLSCUI |
| D00728 | KEGG_DRUG |
| 62TEY51RR1 | UNII |
| 409307004 | SNOMEDCT_US |
| 4018971 | VANDF |
| 001159 | NDDF |
| d01026 | MMSL |
| 4290 | MMSL |
| 19478 | RXNORM |
| 82075003 | SNOMEDCT_US |
| CHEMBL1120 | ChEMBL_ID |
| DB01294 | DRUGBANK_ID |
| CHEBI:261649 | CHEBI |
| 16682734 | PUBCHEM_CID |
| C015715 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-0469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 9 sections |
| basic care stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-7469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 9 sections |
| Pink Bismuth | HUMAN OTC DRUG LABEL | 1 | 0121-4803 | SUSPENSION | 262 mg | ORAL | OTC monograph final | 10 sections |
| Percy Medicine | HUMAN OTC DRUG LABEL | 1 | 0322-2222 | LIQUID | 1050 mg | ORAL | OTC monograph final | 8 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0025 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0073 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0319 | TABLET, CHEWABLE | 262 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0346 | TABLET | 262 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0371 | LIQUID | 1050 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0736 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-7240 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-7370 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9124 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
| Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9125 | TABLET, FILM COATED | 262 mg | ORAL | OTC monograph final | 16 sections |
| Peptic Relief | HUMAN OTC DRUG LABEL | 1 | 0536-1021 | TABLET | 262 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Stomach Relief | HUMAN OTC DRUG LABEL | 1 | 0536-1286 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| Stomach Relief | HUMAN OTC DRUG LABEL | 1 | 0536-1287 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| PINK BISMUTH | HUMAN OTC DRUG LABEL | 1 | 0536-1810 | LIQUID | 262 mg | ORAL | OTC monograph final | 8 sections |
| Bismatrol | HUMAN OTC DRUG LABEL | 1 | 0904-1313 | LIQUID | 262 mg | ORAL | OTC monograph final | 8 sections |
| Bismatrol | HUMAN OTC DRUG LABEL | 1 | 0904-1314 | LIQUID | 525 mg | ORAL | OTC monograph final | 8 sections |
| Bismatrol | HUMAN OTC DRUG LABEL | 1 | 0904-1315 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 8 sections |
| KAO-TIN PEPPERMINT FLAVOR | HUMAN OTC DRUG LABEL | 1 | 0904-5709 | LIQUID | 262 mg | ORAL | OTC monograph final | 8 sections |
| Kola-Pectin | HUMAN OTC DRUG LABEL | 1 | 11026-2639 | LIQUID | 525 mg | ORAL | OTC monograph final | 10 sections |
| up and up 5-symptom digestive relief | HUMAN OTC DRUG LABEL | 1 | 11673-122 | TABLET | 262 mg | ORAL | OTC monograph final | 8 sections |
| up and up 5-symptom digestive relief | HUMAN OTC DRUG LABEL | 1 | 11673-125 | TABLET | 262 mg | ORAL | OTC monograph final | 8 sections |
| Digestive Relief | HUMAN OTC DRUG LABEL | 1 | 11673-372 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| up and up digestive relief | HUMAN OTC DRUG LABEL | 1 | 11673-706 | SUSPENSION | 525 mg | ORAL | OTC monograph final | 9 sections |
| Digestive Relief | HUMAN OTC DRUG LABEL | 1 | 11673-724 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |
| ULTRA STRENGHT PINK BISMUTH | HUMAN OTC DRUG LABEL | 1 | 11673-907 | SUSPENSION | 525 mg | ORAL | OTC monograph final | 9 sections |
| Stomach Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0273 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 9 sections |