Stem definition | Drug id | CAS RN |
---|---|---|
4257 | 14882-18-9 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 15, 1996 | FDA | PROMETHEUS LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 106.43 | 21.38 | 50 | 2890 | 39721 | 50562463 |
Diarrhoea | 63.59 | 21.38 | 118 | 2822 | 588358 | 50013826 |
Cholecystitis chronic | 52.08 | 21.38 | 20 | 2920 | 9649 | 50592535 |
End stage renal disease | 34.99 | 21.38 | 13 | 2927 | 5724 | 50596460 |
Renal injury | 29.88 | 21.38 | 13 | 2927 | 8598 | 50593586 |
Cholelithiasis | 26.35 | 21.38 | 20 | 2920 | 37953 | 50564231 |
Eyelid pain | 23.94 | 21.38 | 5 | 2935 | 260 | 50601924 |
Faeces discoloured | 22.16 | 21.38 | 13 | 2927 | 16111 | 50586073 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 118.49 | 24.97 | 49 | 1324 | 36367 | 29536787 |
End stage renal disease | 41.56 | 24.97 | 15 | 1358 | 7649 | 29565505 |
Diarrhoea | 40.42 | 24.97 | 62 | 1311 | 332636 | 29240518 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic kidney disease | 145.07 | 20.40 | 68 | 3418 | 57851 | 64437395 |
Diarrhoea | 55.86 | 20.40 | 121 | 3365 | 722583 | 63772663 |
End stage renal disease | 48.37 | 20.40 | 19 | 3467 | 10456 | 64484790 |
Cholecystitis chronic | 46.98 | 20.40 | 18 | 3468 | 9269 | 64485977 |
Renal injury | 26.35 | 20.40 | 14 | 3472 | 15415 | 64479831 |
Eyelid pain | 24.04 | 20.40 | 5 | 3481 | 274 | 64494972 |
Nephrogenic anaemia | 22.56 | 20.40 | 8 | 3478 | 3317 | 64491929 |
Vomiting | 22.50 | 20.40 | 73 | 3413 | 551044 | 63944202 |
Cholelithiasis | 22.34 | 20.40 | 19 | 3467 | 45487 | 64449759 |
Abdominal pain upper | 21.67 | 20.40 | 36 | 3450 | 174994 | 64320252 |
Tongue pruritus | 21.25 | 20.40 | 5 | 3481 | 483 | 64494763 |
Gastrooesophageal reflux disease | 20.76 | 20.40 | 24 | 3462 | 83119 | 64412127 |
None
Source | Code | Description |
---|---|---|
FDA CS | M0002611 | Bismuth |
MeSH PA | D000930 | Antidiarrheals |
MeSH PA | D005765 | Gastrointestinal Agents |
FDA EPC | N0000180183 | Bismuth |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Diarrhea | indication | 62315008 | |
Indigestion | indication | 162031009 | |
Duodenal Ulcer due to H. Pylori | indication | ||
Traveler's diarrhea | off-label use | 11840006 | |
Helicobacter pylori-associated gastritis | off-label use | 708164002 | |
Helicobacter Pylori Gastritis | off-label use | ||
Alcoholism | contraindication | 7200002 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Alcohol intoxication | contraindication | 25702006 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Seizure disorder | contraindication | 128613002 | |
Non-infective meningitis | contraindication | 230155003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cyclooxygenase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018971 | VUID |
N0000147252 | NUI |
D00728 | KEGG_DRUG |
4018971 | VANDF |
C0053792 | UMLSCUI |
CHEBI:261649 | CHEBI |
CHEMBL1120 | ChEMBL_ID |
DB01294 | DRUGBANK_ID |
C015715 | MESH_SUPPLEMENTAL_RECORD_UI |
62TEY51RR1 | UNII |
16682734 | PUBCHEM_CID |
19478 | RXNORM |
4290 | MMSL |
d01026 | MMSL |
001159 | NDDF |
409307004 | SNOMEDCT_US |
82075003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
good sense stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-0469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
good sense stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-0469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
basic care stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-7469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
basic care stomach relief | HUMAN OTC DRUG LABEL | 1 | 0113-7469 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
Stomach Relief | HUMAN OTC DRUG LABEL | 1 | 0121-0910 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Stomach Relief | HUMAN OTC DRUG LABEL | 1 | 0121-0910 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Pink Bismuth | HUMAN OTC DRUG LABEL | 1 | 0121-4803 | SUSPENSION | 262 mg | ORAL | OTC monograph final | 17 sections |
Percy Medicine | HUMAN OTC DRUG LABEL | 1 | 0322-2222 | LIQUID | 1050 mg | ORAL | OTC monograph final | 8 sections |
Percy Medicine | HUMAN OTC DRUG LABEL | 1 | 0322-2222 | LIQUID | 1050 mg | ORAL | OTC monograph final | 8 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0025 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0025 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0073 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0073 | LIQUID | 525 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0319 | TABLET, CHEWABLE | 262 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0319 | TABLET, CHEWABLE | 262 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0346 | TABLET | 262 mg | ORAL | OTC monograph final | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0346 | TABLET | 262 mg | ORAL | OTC monograph final | 16 sections |
SootheMaximum Strength | HUMAN OTC DRUG LABEL | 1 | 0363-0371 | LIQUID | 1050 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
SootheMaximum Strength | HUMAN OTC DRUG LABEL | 1 | 0363-0371 | LIQUID | 1050 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0736 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-0736 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-7240 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Soothe | HUMAN OTC DRUG LABEL | 1 | 0363-7240 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
SootheUltra Strength | HUMAN OTC DRUG LABEL | 1 | 0363-7370 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
SootheUltra Strength | HUMAN OTC DRUG LABEL | 1 | 0363-7370 | LIQUID | 525 mg | ORAL | OTC monograph final | 16 sections |
Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9124 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9124 | TABLET, CHEWABLE | 262 mg | ORAL | OTC monograph final | 16 sections |
Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9125 | TABLET, FILM COATED | 262 mg | ORAL | OTC monograph final | 16 sections |
Walgreen | HUMAN OTC DRUG LABEL | 1 | 0363-9125 | TABLET, FILM COATED | 262 mg | ORAL | OTC monograph final | 16 sections |
Peptic Relief | HUMAN OTC DRUG LABEL | 1 | 0536-1021 | TABLET | 262 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |