bismuth subsalicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4257	14882-18-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: bismuth subsalicylate bismogenol bismuth oxysalicylate	bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter Molecular weight: 362.09 Formula: C7H5BiO4 CLOGP: 0.34 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 55.76 ALOGS: -0.78 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bismuth subsalicylate
bismogenol
bismuth oxysalicylate

bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter

Molecular weight: 362.09
Formula: C7H5BiO4
CLOGP: 0.34
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 55.76
ALOGS: -0.78
ROTB: 0

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 15, 1996	FDA	PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic kidney disease	106.43	21.38	50	2890	39721	50562463
Diarrhoea	63.59	21.38	118	2822	588358	50013826
Cholecystitis chronic	52.08	21.38	20	2920	9649	50592535
End stage renal disease	34.99	21.38	13	2927	5724	50596460
Renal injury	29.88	21.38	13	2927	8598	50593586
Cholelithiasis	26.35	21.38	20	2920	37953	50564231
Eyelid pain	23.94	21.38	5	2935	260	50601924
Faeces discoloured	22.16	21.38	13	2927	16111	50586073

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic kidney disease	118.49	24.97	49	1324	36367	29536787
End stage renal disease	41.56	24.97	15	1358	7649	29565505
Diarrhoea	40.42	24.97	62	1311	332636	29240518

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic kidney disease	145.07	20.40	68	3418	57851	64437395
Diarrhoea	55.86	20.40	121	3365	722583	63772663
End stage renal disease	48.37	20.40	19	3467	10456	64484790
Cholecystitis chronic	46.98	20.40	18	3468	9269	64485977
Renal injury	26.35	20.40	14	3472	15415	64479831
Eyelid pain	24.04	20.40	5	3481	274	64494972
Nephrogenic anaemia	22.56	20.40	8	3478	3317	64491929
Vomiting	22.50	20.40	73	3413	551044	63944202
Cholelithiasis	22.34	20.40	19	3467	45487	64449759
Abdominal pain upper	21.67	20.40	36	3450	174994	64320252
Tongue pruritus	21.25	20.40	5	3481	483	64494763
Gastrooesophageal reflux disease	20.76	20.40	24	3462	83119	64412127

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA CS	M0002611	Bismuth
MeSH PA	D000930	Antidiarrheals
MeSH PA	D005765	Gastrointestinal Agents
FDA EPC	N0000180183	Bismuth

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diarrhea	indication	62315008
Indigestion	indication	162031009
Duodenal Ulcer due to H. Pylori	indication
Traveler's diarrhea	off-label use	11840006
Helicobacter pylori-associated gastritis	off-label use	708164002
Helicobacter Pylori Gastritis	off-label use
Alcoholism	contraindication	7200002
Lowered convulsive threshold	contraindication	19260006
Alcohol intoxication	contraindication	25702006
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Diabetes mellitus	contraindication	73211009	DOID:9351
Disorder of brain	contraindication	81308009	DOID:936
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Non-infective meningitis	contraindication	230155003
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Peripheral nerve disease	contraindication	302226006
Neutropenic disorder	contraindication	303011007	DOID:1227
Pseudomembranous enterocolitis	contraindication	397683000
Breastfeeding (mother)	contraindication	413712001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cyclooxygenase	Enzyme	P23219 P35354	PGH1_HUMAN PGH2_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018971	VUID
N0000147252	NUI
D00728	KEGG_DRUG
4018971	VANDF
C0053792	UMLSCUI
CHEBI:261649	CHEBI
CHEMBL1120	ChEMBL_ID
DB01294	DRUGBANK_ID
C015715	MESH_SUPPLEMENTAL_RECORD_UI
62TEY51RR1	UNII
16682734	PUBCHEM_CID
19478	RXNORM
4290	MMSL
d01026	MMSL
001159	NDDF
409307004	SNOMEDCT_US
82075003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense stomach relief	HUMAN OTC DRUG LABEL	1	0113-0469	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
good sense stomach relief	HUMAN OTC DRUG LABEL	1	0113-0469	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
basic care stomach relief	HUMAN OTC DRUG LABEL	1	0113-7469	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
basic care stomach relief	HUMAN OTC DRUG LABEL	1	0113-7469	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
Stomach Relief	HUMAN OTC DRUG LABEL	1	0121-0910	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Stomach Relief	HUMAN OTC DRUG LABEL	1	0121-0910	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Pink Bismuth	HUMAN OTC DRUG LABEL	1	0121-4803	SUSPENSION	262 mg	ORAL	OTC monograph final	17 sections
Percy Medicine	HUMAN OTC DRUG LABEL	1	0322-2222	LIQUID	1050 mg	ORAL	OTC monograph final	8 sections
Percy Medicine	HUMAN OTC DRUG LABEL	1	0322-2222	LIQUID	1050 mg	ORAL	OTC monograph final	8 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0025	LIQUID	525 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0025	LIQUID	525 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0073	LIQUID	525 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0073	LIQUID	525 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0319	TABLET, CHEWABLE	262 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0319	TABLET, CHEWABLE	262 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0346	TABLET	262 mg	ORAL	OTC monograph final	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0346	TABLET	262 mg	ORAL	OTC monograph final	16 sections
SootheMaximum Strength	HUMAN OTC DRUG LABEL	1	0363-0371	LIQUID	1050 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
SootheMaximum Strength	HUMAN OTC DRUG LABEL	1	0363-0371	LIQUID	1050 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0736	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-0736	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-7240	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Soothe	HUMAN OTC DRUG LABEL	1	0363-7240	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
SootheUltra Strength	HUMAN OTC DRUG LABEL	1	0363-7370	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
SootheUltra Strength	HUMAN OTC DRUG LABEL	1	0363-7370	LIQUID	525 mg	ORAL	OTC monograph final	16 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-9124	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-9124	TABLET, CHEWABLE	262 mg	ORAL	OTC monograph final	16 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-9125	TABLET, FILM COATED	262 mg	ORAL	OTC monograph final	16 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-9125	TABLET, FILM COATED	262 mg	ORAL	OTC monograph final	16 sections
Peptic Relief	HUMAN OTC DRUG LABEL	1	0536-1021	TABLET	262 mg	ORAL	OTC MONOGRAPH FINAL	15 sections