All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium monofluorophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4252	10163-15-2

Description:

Molecule	Description
Synonyms: sodium monofluorophosphate sodium phosphorofluoridate disodium fluorophosphate disodium monofluorophosphate sodium fluorophosphate	inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd Molecular weight: 143.95 Formula: FNa2O3P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 63.19 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 6, 1986	FDA	CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	27.28	23.85	19	788	145654	63342561

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	122.50	30.64	23	797	1759	34954352
Respiratory tract infection viral	120.59	30.64	24	796	2493	34953618
Cytokine release syndrome	83.73	30.64	28	792	22849	34933262
Fibrin D dimer increased	75.85	30.64	18	802	4226	34951885
Respiratory tract infection	71.59	30.64	24	796	19688	34936423
Thrombocytopenia	35.05	30.64	29	791	156218	34799893
COVID-19	32.42	30.64	21	799	77529	34878582
Pulmonary embolism	31.98	30.64	22	798	89724	34866387
C-reactive protein increased	31.18	30.64	18	802	54080	34902031

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	122.93	24.10	23	1542	2054	79740769
Respiratory tract infection viral	112.11	24.10	24	1541	4235	79738588
Cytokine release syndrome	91.04	24.10	32	1533	35966	79706857
Fibrin D dimer increased	66.21	24.10	18	1547	8636	79734187
Respiratory tract infection	57.75	24.10	25	1540	48664	79694159
Platelet count decreased	40.09	24.10	32	1533	194632	79548191
Pulmonary embolism	37.01	24.10	29	1536	171625	79571198
Hypotension	30.25	24.10	40	1525	440277	79302546
Thrombocytopenia	29.73	24.10	31	1534	265228	79477595
Pyrexia	25.95	24.10	47	1518	678662	79064161

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AA02	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
ATC	A12CD02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Fluoride
MeSH PA	D002327	Cariostatic Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:33282	bactericides

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05864	KEGG_DRUG
C0142890	UMLSCUI
CHEBI:86431	CHEBI
CHEMBL1908359	ChEMBL_ID
DB09484	DRUGBANK_ID
C012980	MESH_SUPPLEMENTAL_RECORD_UI
C810JCZ56Q	UNII
24266	PUBCHEM_CID
56501	RXNORM
41604	MMSL
NOCODE	MMSL
004405	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
biotene	HUMAN OTC DRUG LABEL	1	0135-0577	PASTE	1.40 mg	ORAL	OTC monograph final	12 sections
AquafreshKids Cavity Protection	HUMAN OTC DRUG LABEL	1	0135-0619	PASTE	1.10 mg	DENTAL	OTC monograph final	11 sections
AquafreshKids Cavity Protection	HUMAN OTC DRUG LABEL	1	0135-0619	PASTE	1.10 mg	DENTAL	OTC monograph final	11 sections
Ology Fluoride	HUMAN OTC DRUG LABEL	1	0363-2008	PASTE	7.60 mg	DENTAL	OTC monograph final	8 sections
Truly Radiant Clean and Fresh	HUMAN OTC DRUG LABEL	1	10237-668	PASTE, DENTIFRICE	0.83 mg	DENTAL	OTC monograph final	9 sections
Truly Radiant Clean and Fresh	HUMAN OTC DRUG LABEL	1	10237-668	PASTE, DENTIFRICE	0.83 mg	DENTAL	OTC monograph final	9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack	HUMAN OTC DRUG LABEL	1	10237-673	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC monograph final	9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack	HUMAN OTC DRUG LABEL	1	10237-673	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC monograph final	9 sections
Rite Aid Brilliant White	HUMAN OTC DRUG LABEL	1	11822-6032	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
DENBLAN WHITENING FORMULA ANTI CAVITY FLUORIDE	HUMAN OTC DRUG LABEL	1	16555-996	PASTE, DENTIFRICE	0.76 mL	DENTAL	OTC MONOGRAPH FINAL	10 sections
Lucky Super SoftAnti Cavity with Free Toothbrush	HUMAN OTC DRUG LABEL	1	20276-551	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftWhitening Anti Cavity with Free Toothbrush	HUMAN OTC DRUG LABEL	1	20276-552	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftWhitening Anti Cavity	HUMAN OTC DRUG LABEL	1	20276-553	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftAnti Cavity	HUMAN OTC DRUG LABEL	1	20276-554	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Kids Strawberry FTP	HUMAN OTC DRUG LABEL	1	21130-417	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	8 sections
Kids Strawberry FTP	HUMAN OTC DRUG LABEL	1	21130-417	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	8 sections
NBF Gingival	HUMAN OTC DRUG LABEL	1	23636-1001	GEL	0.40 g	DENTAL	unapproved drug other	8 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-0819	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-2238	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-9181	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-9223	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Simple Truth Kids Flouride	HUMAN OTC DRUG LABEL	1	30142-146	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	10 sections
Simple Truth Kids Flouride	HUMAN OTC DRUG LABEL	1	30142-146	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	10 sections
Natural Adult Fluoride	HUMAN OTC DRUG LABEL	1	30142-223	PASTE	0.76 g	DENTAL	OTC monograph final	8 sections
Natural Adult Fluoride	HUMAN OTC DRUG LABEL	1	30142-223	PASTE	0.76 g	DENTAL	OTC monograph final	8 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
CO Oh So Dazzling Sweet Mint	HUMAN OTC DRUG LABEL	1	35000-135	PASTE, DENTIFRICE	1.50 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
COLGATE Great Regular Flavor	HUMAN OTC DRUG LABEL	1	35000-257	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections