sodium monofluorophosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4252 10163-15-2

Description:

MoleculeDescription

Synonyms:

  • sodium monofluorophosphate
  • sodium phosphorofluoridate
  • disodium fluorophosphate
  • disodium monofluorophosphate
  • sodium fluorophosphate
inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd
  • Molecular weight: 143.95
  • Formula: FNa2O3P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 63.19
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 6, 1986 FDA CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 81.93 42.17 16 21 21018 2337030
Toxicity to various agents 68.93 42.17 15 22 32739 2325309

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC A01AA02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Caries prophylactic agents
ATC A12CD02 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Fluoride

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0142890 UMLSCUI
D05864 KEGG_DRUG
NOCODE MMSL
56501 RXNORM
004405 NDDF
C810JCZ56Q UNII
DB09484 DRUGBANK_ID
CHEBI:86431 CHEBI
CHEMBL1908359 ChEMBL_ID
24266 PUBCHEM_CID
C012980 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BIOTENE HUMAN OTC DRUG LABEL 1 0135-0487 PASTE 1.40 mg ORAL OTC monograph final 9 sections
biotene HUMAN OTC DRUG LABEL 1 0135-0577 PASTE 1.40 mg ORAL OTC monograph final 9 sections
Aquafresh HUMAN OTC DRUG LABEL 1 0135-0619 PASTE 1.10 mg DENTAL OTC monograph final 9 sections
Ology Fluoride HUMAN OTC DRUG LABEL 1 0363-2008 PASTE 7.60 mg DENTAL OTC monograph final 8 sections
Truly Radiant Clean and Fresh HUMAN OTC DRUG LABEL 1 10237-668 PASTE, DENTIFRICE 0.83 mg DENTAL OTC monograph final 9 sections
Rite Aid HUMAN OTC DRUG LABEL 1 11822-6032 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
DENBLAN HUMAN OTC DRUG LABEL 1 16555-996 PASTE, DENTIFRICE 0.76 mL DENTAL OTC MONOGRAPH FINAL 8 sections
Lucky Super Soft HUMAN OTC DRUG LABEL 1 20276-551 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super Soft HUMAN OTC DRUG LABEL 1 20276-552 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super Soft HUMAN OTC DRUG LABEL 1 20276-553 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super Soft HUMAN OTC DRUG LABEL 1 20276-554 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
NBF Gingival HUMAN OTC DRUG LABEL 1 23636-1001 GEL 0.40 g DENTAL unapproved drug other 7 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-0819 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-2238 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-9181 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-9223 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Simple Truth HUMAN OTC DRUG LABEL 1 30142-146 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Kroger Company HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
COLGATE Great Regular Flavor HUMAN OTC DRUG LABEL 1 35000-913 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate HUMAN OTC DRUG LABEL 1 35000-916 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate HUMAN OTC DRUG LABEL 1 35000-919 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White High Impact Fluoride HUMAN OTC DRUG LABEL 1 35000-925 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
COLGATE HUMAN OTC DRUG LABEL 1 35000-929 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White Beauty Radiant HUMAN OTC DRUG LABEL 1 35000-934 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White Platinum HUMAN OTC DRUG LABEL 1 35000-951 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White Platinum Anticavity Fluoride HUMAN OTC DRUG LABEL 1 35000-952 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 9 sections
COLGATE HUMAN OTC DRUG LABEL 1 35000-959 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate HUMAN OTC DRUG LABEL 1 35000-960 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White HUMAN OTC DRUG LABEL 1 35000-961 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections
Colgate Optic White Sparkling Mint Flavor HUMAN OTC DRUG LABEL 1 35000-963 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 9 sections