sodium monofluorophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4252 10163-15-2

Description:

MoleculeDescription

Synonyms:

  • sodium monofluorophosphate
  • sodium phosphorofluoridate
  • disodium fluorophosphate
  • disodium monofluorophosphate
  • sodium fluorophosphate
inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd
  • Molecular weight: 143.95
  • Formula: FNa2O3P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 63.19
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 6, 1986 FDA CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 30.68 23.76 18 487 131871 50472748
Toxicity to various agents 25.07 23.76 19 486 212480 50392139

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AA02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Caries prophylactic agents
ATC A12CD02 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Fluoride
MeSH PA D002327 Cariostatic Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:33282 bactericides

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05864 KEGG_DRUG
C0142890 UMLSCUI
CHEBI:86431 CHEBI
CHEMBL1908359 ChEMBL_ID
DB09484 DRUGBANK_ID
C012980 MESH_SUPPLEMENTAL_RECORD_UI
C810JCZ56Q UNII
24266 PUBCHEM_CID
56501 RXNORM
NOCODE MMSL
004405 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AquafreshKids Cavity Protection HUMAN OTC DRUG LABEL 1 0135-0619 PASTE 1.10 mg DENTAL OTC monograph final 11 sections
Ology Fluoride HUMAN OTC DRUG LABEL 1 0363-2008 PASTE 7.60 mg DENTAL OTC monograph final 8 sections
Truly Radiant Clean and Fresh HUMAN OTC DRUG LABEL 1 10237-668 PASTE, DENTIFRICE 0.83 mg DENTAL OTC monograph final 9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack HUMAN OTC DRUG LABEL 1 10237-673 PASTE, DENTIFRICE 1.10 mg DENTAL OTC monograph final 9 sections
DENBLAN WHITENING FORMULA ANTI CAVITY FLUORIDE HUMAN OTC DRUG LABEL 1 16555-996 PASTE, DENTIFRICE 0.76 mL DENTAL OTC MONOGRAPH FINAL 10 sections
Lucky Super SoftAnti Cavity with Free Toothbrush HUMAN OTC DRUG LABEL 1 20276-551 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftWhitening Anti Cavity with Free Toothbrush HUMAN OTC DRUG LABEL 1 20276-552 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftWhitening Anti Cavity HUMAN OTC DRUG LABEL 1 20276-553 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftAnti Cavity HUMAN OTC DRUG LABEL 1 20276-554 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Kids Strawberry FTP HUMAN OTC DRUG LABEL 1 21130-417 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
NBF Gingival HUMAN OTC DRUG LABEL 1 23636-1001 GEL 0.40 g DENTAL unapproved drug other 8 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-0819 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-2238 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-9181 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-9223 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Simple Truth Kids Flouride HUMAN OTC DRUG LABEL 1 30142-146 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 10 sections
Natural Adult Fluoride HUMAN OTC DRUG LABEL 1 30142-223 PASTE 0.76 g DENTAL OTC monograph final 8 sections
Kroger CompanyRadiant White HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Kroger CompanyRadiant White HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
CO Oh So Dazzling Sweet Mint HUMAN OTC DRUG LABEL 1 35000-135 PASTE, DENTIFRICE 1.50 mg DENTAL OTC MONOGRAPH FINAL 10 sections
COLGATE Great Regular Flavor HUMAN OTC DRUG LABEL 1 35000-257 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate Optic White Pro Series Stain Prevention HUMAN OTC DRUG LABEL 1 35000-747 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate Optic White ProSeries Enamel Strenght HUMAN OTC DRUG LABEL 1 35000-748 PASTE, DENTIFRICE 1.50 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate Optic White ProSeries Vividly Fresh HUMAN OTC DRUG LABEL 1 35000-749 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate Optic White Stain Prevention HUMAN OTC DRUG LABEL 1 35000-893 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 10 sections
COLGATE Great Regular Flavor HUMAN OTC DRUG LABEL 1 35000-913 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate ULTRA BRITE Baking Soda and Peroxide Whitening HUMAN OTC DRUG LABEL 1 35000-916 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 11 sections
Colgate Sparkling White Mint Zing HUMAN OTC DRUG LABEL 1 35000-919 GEL, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 10 sections
Colgate Optic White Platinum Anticavity Fluoride HUMAN OTC DRUG LABEL 1 35000-952 PASTE, DENTIFRICE 1.10 mg DENTAL OTC MONOGRAPH FINAL 10 sections
COLGATE Baking Soda and Peroxide Whitening Brisk Mint HUMAN OTC DRUG LABEL 1 35000-959 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 11 sections