All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium monofluorophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4252	10163-15-2

Description:

Molecule	Description
Synonyms: sodium monofluorophosphate sodium phosphorofluoridate disodium fluorophosphate disodium monofluorophosphate sodium fluorophosphate	inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd Molecular weight: 143.95 Formula: FNa2O3P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 63.19 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 6, 1986	FDA	CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	37.33	23.88	20	498	133813	56157736
Toxicity to various agents	25.50	23.88	19	499	224545	56067004

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	102.51	32.42	18	473	1448	31695405
Respiratory tract infection viral	96.80	32.42	18	473	1996	31694857
Respiratory tract infection	62.31	32.42	19	472	17542	31679311
Cytokine release syndrome	50.56	32.42	16	475	16626	31680227

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	100.45	23.33	18	1012	1719	70925695
Respiratory tract infection viral	87.65	23.33	18	1012	3523	70923891
Cytokine release syndrome	55.67	23.33	19	1011	26448	70900966
Respiratory tract infection	50.41	23.33	20	1010	42378	70885036
Platelet count decreased	34.53	23.33	25	1005	178197	70749217
Pulmonary embolism	32.80	23.33	23	1007	155844	70771570

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AA02	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
ATC	A12CD02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Fluoride
MeSH PA	D002327	Cariostatic Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:33282	bactericides

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05864	KEGG_DRUG
C0142890	UMLSCUI
CHEBI:86431	CHEBI
CHEMBL1908359	ChEMBL_ID
DB09484	DRUGBANK_ID
C012980	MESH_SUPPLEMENTAL_RECORD_UI
C810JCZ56Q	UNII
24266	PUBCHEM_CID
56501	RXNORM
NOCODE	MMSL
004405	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
biotene	HUMAN OTC DRUG LABEL	1	0135-0577	PASTE	1.40 mg	ORAL	OTC monograph final	12 sections
AquafreshKids Cavity Protection	HUMAN OTC DRUG LABEL	1	0135-0619	PASTE	1.10 mg	DENTAL	OTC monograph final	11 sections
Ology Fluoride	HUMAN OTC DRUG LABEL	1	0363-2008	PASTE	7.60 mg	DENTAL	OTC monograph final	8 sections
Truly Radiant Clean and Fresh	HUMAN OTC DRUG LABEL	1	10237-668	PASTE, DENTIFRICE	0.83 mg	DENTAL	OTC monograph final	9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack	HUMAN OTC DRUG LABEL	1	10237-673	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC monograph final	9 sections
DENBLAN WHITENING FORMULA ANTI CAVITY FLUORIDE	HUMAN OTC DRUG LABEL	1	16555-996	PASTE, DENTIFRICE	0.76 mL	DENTAL	OTC MONOGRAPH FINAL	10 sections
Lucky Super SoftAnti Cavity with Free Toothbrush	HUMAN OTC DRUG LABEL	1	20276-551	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftWhitening Anti Cavity with Free Toothbrush	HUMAN OTC DRUG LABEL	1	20276-552	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftWhitening Anti Cavity	HUMAN OTC DRUG LABEL	1	20276-553	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftAnti Cavity	HUMAN OTC DRUG LABEL	1	20276-554	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Kids Strawberry FTP	HUMAN OTC DRUG LABEL	1	21130-417	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	8 sections
NBF Gingival	HUMAN OTC DRUG LABEL	1	23636-1001	GEL	0.40 g	DENTAL	unapproved drug other	8 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-0819	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-2238	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-9181	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-9223	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Simple Truth Kids Flouride	HUMAN OTC DRUG LABEL	1	30142-146	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	10 sections
Natural Adult Fluoride	HUMAN OTC DRUG LABEL	1	30142-223	PASTE	0.76 g	DENTAL	OTC monograph final	8 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
CO Oh So Dazzling Sweet Mint	HUMAN OTC DRUG LABEL	1	35000-135	PASTE, DENTIFRICE	1.50 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
COLGATE Great Regular Flavor	HUMAN OTC DRUG LABEL	1	35000-257	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate Optic White Pro Series Stain Prevention	HUMAN OTC DRUG LABEL	1	35000-747	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate Optic White ProSeries Enamel Strenght	HUMAN OTC DRUG LABEL	1	35000-748	PASTE, DENTIFRICE	1.50 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate Optic White ProSeries Vividly Fresh	HUMAN OTC DRUG LABEL	1	35000-749	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate Optic White Sparkling	HUMAN OTC DRUG LABEL	1	35000-758	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate Optic White Stain Prevention	HUMAN OTC DRUG LABEL	1	35000-893	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
COLGATE Great Regular Flavor	HUMAN OTC DRUG LABEL	1	35000-913	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections
Colgate ULTRA BRITE Baking Soda and Peroxide Whitening	HUMAN OTC DRUG LABEL	1	35000-916	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH FINAL	11 sections
Colgate Sparkling White Mint Zing	HUMAN OTC DRUG LABEL	1	35000-919	GEL, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH FINAL	10 sections