AI ASSISTANT

Ask DrugCentral

Explore drug properties, targets, and indications with answers grounded in DrugCentral.

Your question

Ask in your own words. Each question is answered independently.

Explore sample questions

Select a question to fill the editor, then ask it or make it your own.

DrugCentral answer

Your answer will appear here. Open linked drug cards in a new tab to explore the source details.

AI can make mistakes. Verify answers against the original sources before relying on them.

Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4252	10163-15-2

Description:

Molecule	Description
Synonyms: sodium monofluorophosphate sodium phosphorofluoridate disodium fluorophosphate disodium monofluorophosphate sodium fluorophosphate	inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd Molecular weight: 143.95 Formula: FNa2O3P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 63.19 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium monofluorophosphate
sodium phosphorofluoridate
disodium fluorophosphate
disodium monofluorophosphate
sodium fluorophosphate

inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd

Molecular weight: 143.95
Formula: FNa2O3P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 63.19
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Aug. 6, 1986	FDA	CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Walking aid user	125.38	23.74	60	7281	35446	90585660
Prescribed underdose	114.86	23.74	73	7268	74946	90546160
Wound infection	96.19	23.74	75	7266	106327	90514779
Seronegative arthritis	90.24	23.74	39	7302	18195	90602911
Upper respiratory tract infection	79.96	23.74	73	7268	128245	90492861
Spinal fusion surgery	76.67	23.74	31	7310	12252	90608854
Visual impairment	68.56	23.74	68	7273	132297	90488809
Joint dislocation	59.90	23.74	40	7301	44542	90576564
Spondylitis	59.45	23.74	27	7314	14151	90606955
Lupus vulgaris	57.12	23.74	39	7302	45020	90576086
Type 2 diabetes mellitus	56.96	23.74	76	7265	203168	90417938
Osteoporosis	54.48	23.74	52	7289	96479	90524627
Retinitis	52.85	23.74	35	7306	38423	90582683
Laryngitis	48.48	23.74	37	7304	50716	90570390
Hepatic cirrhosis	47.41	23.74	40	7301	63213	90557893
Foot deformity	47.36	23.74	39	7302	59612	90561494
Drug ineffective	47.19	23.74	27	7314	1384271	89236835
Anti-cyclic citrullinated peptide antibody	45.41	23.74	28	7313	27193	90593913
Lupus-like syndrome	45.32	23.74	35	7306	48811	90572295
Wheezing	45.00	23.74	74	7267	238006	90383100
Adjustment disorder with depressed mood	44.83	23.74	37	7304	56716	90564390
Dislocation of vertebra	43.19	23.74	36	7305	55932	90565174
Joint stiffness	42.06	23.74	41	7300	78001	90543105
Exostosis	38.58	23.74	33	7308	53101	90568005
Grip strength decreased	36.23	23.74	41	7300	92535	90528571
Prescribed overdose	36.12	23.74	42	7299	97583	90523523
Deep vein thrombosis postoperative	35.92	23.74	36	7305	70773	90550333
Hip arthroplasty	35.50	23.74	37	7304	76171	90544935
Bone erosion	34.62	23.74	31	7310	52990	90568116
Osteoarthritis	34.51	23.74	59	7282	195671	90425435
Liver function test increased	33.92	23.74	38	7303	84817	90536289
Wound	33.50	23.74	75	7266	302905	90318201
Disability	33.09	23.74	27	7314	40718	90580388
Red blood cell sedimentation rate increased	33.03	23.74	37	7304	82558	90538548
Urticaria	33.01	23.74	76	7265	312658	90308448
Oedema	32.23	23.74	58	7283	200237	90420869
Sciatica	31.61	23.74	40	7301	101342	90519764
Lower limb fracture	30.49	23.74	36	7305	84977	90536129
Autoimmune disorder	30.04	23.74	34	7307	76710	90544396
Ear infection	29.18	23.74	32	7309	69743	90551363
Delirium	29.15	23.74	39	7302	104320	90516786
Gait inability	28.28	23.74	46	7295	146410	90474696
Pulmonary fibrosis	28.25	23.74	39	7302	107464	90513642
Weight increased	27.29	23.74	85	7256	417842	90203264
Hypercholesterolaemia	27.11	23.74	37	7304	100855	90520251
Road traffic accident	26.72	23.74	38	7303	107588	90513518
Fibromyalgia	26.15	23.74	54	7287	206215	90414891
Vertebral lateral recess stenosis	26.13	23.74	6	7335	346	90620760
Osteoarthropathy	25.86	23.74	6	7335	362	90620744
Breast cancer stage III	25.82	23.74	33	7308	84414	90536692
Swollen joint count increased	25.77	23.74	38	7303	111168	90509938
Ligamentum flavum hypertrophy	25.72	23.74	6	7335	371	90620735
Amnesia	25.03	23.74	37	7304	108468	90512638
Joint range of motion decreased	24.04	23.74	41	7300	135602	90485504

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	119.92	28.72	22	766	1887	42618660
Respiratory tract infection viral	113.11	28.72	23	765	3383	42617164
Fibrin D dimer increased	71.97	28.72	17	771	4968	42615579
Respiratory tract infection	66.49	28.72	23	765	26299	42594248
Cytokine release syndrome	61.53	28.72	25	763	44502	42576045
Thrombocytopenia	36.11	28.72	29	759	190250	42430297
C-reactive protein increased	29.76	28.72	17	771	63543	42557004
COVID-19	29.29	28.72	21	767	115927	42504620

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	98.97	20.21	22	4127	2394	110582756
Respiratory tract infection viral	84.17	20.21	23	4126	5855	110579295
Fibrin D dimer increased	48.50	20.21	17	4132	9828	110575322
Cytokine release syndrome	40.86	20.21	28	4121	70278	110514872
Respiratory tract infection	33.51	20.21	25	4124	71592	110513558
Vertebral lateral recess stenosis	30.73	20.21	6	4143	346	110584804
Ligamentum flavum hypertrophy	30.35	20.21	6	4143	369	110584781
Osteoarthropathy	30.29	20.21	6	4143	373	110584777
Seronegative arthritis	30.02	20.21	13	4136	13164	110571986
Toe operation	24.41	20.21	6	4143	1008	110584142
Spinal fusion surgery	24.07	20.21	10	4139	9146	110576004
Prescribed underdose	22.44	20.21	19	4130	65155	110519995

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AA02	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
ATC	A12CD02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Fluoride
MeSH PA	D002327	Cariostatic Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:33282	antibacterial agent

Related Drugs by ATC class:

A01AA Caries prophylactic agents 3 drugs

olaflur sodium fluoride stannous fluoride

A12CD Fluoride 1 drug

sodium fluoride

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05864	KEGG_DRUG
C0142890	UMLSCUI
CHEBI:86431	CHEBI
CHEMBL1908359	ChEMBL_ID
DB09484	DRUGBANK_ID
C012980	MESH_SUPPLEMENTAL_RECORD_UI
C810JCZ56Q	UNII
24266	PUBCHEM_CID
56501	RXNORM
41604	MMSL
NOCODE	MMSL
004405	NDDF
C810JCZ56Q	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
biotene	HUMAN OTC DRUG LABEL	1	0135-0577	PASTE	1.40 mg	ORAL	OTC Monograph Drug	12 sections
Ology Fluoride	HUMAN OTC DRUG LABEL	1	0363-2008	PASTE	7.60 mg	DENTAL	OTC monograph final	8 sections
Whitening	HUMAN OTC DRUG LABEL	1	11673-385	PASTE, DENTIFRICE	0.14 g	DENTAL	OTC Monograph Drug	8 sections
Kids Strawberry FTP	HUMAN OTC DRUG LABEL	1	11673-441	PASTE, DENTIFRICE	0.13 g	DENTAL	OTC Monograph Drug	8 sections
DENBLAN WHITENING FORMULA ANTI CAVITY FLUORIDE	HUMAN OTC DRUG LABEL	1	16555-996	PASTE, DENTIFRICE	0.76 mL	DENTAL	OTC MONOGRAPH FINAL	10 sections
Lucky Super SoftWhitening Anti Cavity	HUMAN OTC DRUG LABEL	1	20276-553	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
Lucky Super SoftAnti Cavity	HUMAN OTC DRUG LABEL	1	20276-554	PASTE, DENTIFRICE	7.60 mg	DENTAL	OTC monograph final	8 sections
NBF Gingival	HUMAN OTC DRUG LABEL	1	23636-1001	GEL	0.40 g	DENTAL	unapproved drug other	8 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-0819	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-2238	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
ADVANCED FLUORIDE ANTICAVITY	HUMAN OTC DRUG LABEL	1	29500-9181	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Advanced Whitening Anticavity Fluoride	HUMAN OTC DRUG LABEL	1	29500-9223	PASTE, DENTIFRICE	1000 mg	DENTAL	OTC monograph final	8 sections
Simple TruthKids Flouride	HUMAN OTC DRUG LABEL	1	30142-146	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC Monograph Drug	10 sections
Natural Adult Fluoride	HUMAN OTC DRUG LABEL	1	30142-223	PASTE	0.76 g	DENTAL	OTC Monograph Drug	8 sections
Kroger CompanyRadiant White	HUMAN OTC DRUG LABEL	1	30142-621	PASTE, DENTIFRICE	0.76 g	DENTAL	OTC monograph final	9 sections
Colgate Revitalizing White	HUMAN OTC DRUG LABEL	1	35000-017	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Colgate Cavity Protection Great Regular Flavor	HUMAN OTC DRUG LABEL	1	35000-060	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Hello Whipped Peppermint Stick Flavor	HUMAN OTC DRUG LABEL	1	35000-512	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Hello Whipped Mellow Mint Dream Flavor	HUMAN OTC DRUG LABEL	1	35000-513	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Hello Activated Charcoal	HUMAN OTC DRUG LABEL	1	35000-678	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Hello Naturally Whitening	HUMAN OTC DRUG LABEL	1	35000-682	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	11 sections
Hello Naturally Whitening	HUMAN OTC DRUG LABEL	1	35000-682	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	11 sections
Colgate Optic White Pro Series Stain Prevention	HUMAN OTC DRUG LABEL	1	35000-747	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Colgate Optic White ProSeries Enamel Strenght	HUMAN OTC DRUG LABEL	1	35000-748	PASTE, DENTIFRICE	1.50 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Colgate Optic White ProSeries Vividly Fresh	HUMAN OTC DRUG LABEL	1	35000-749	PASTE, DENTIFRICE	1.10 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
COLGATE OPTIC WHITE PRO SERIES	HUMAN OTC DRUG LABEL	1	35000-791	PASTE, DENTIFRICE	11.40 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
COLGATE OPTIC WHITE PRO SERIES HI WHITE	HUMAN OTC DRUG LABEL	1	35000-792	PASTE, DENTIFRICE	1.50 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
COLGATE OPTIC WHITE PRO SERIES EXPRESS WHITE	HUMAN OTC DRUG LABEL	1	35000-794	PASTE, DENTIFRICE	0.98 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
OPTIC WHITE PRO SERIES VIBRANT CLEAN	HUMAN OTC DRUG LABEL	1	35000-795	PASTE, DENTIFRICE	0.98 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections
Colgate Optic White Stain Prevention	HUMAN OTC DRUG LABEL	1	35000-893	PASTE, DENTIFRICE	1 mg	DENTAL	OTC MONOGRAPH DRUG	10 sections

Ask DrugCentral

Your question

DrugCentral answer

About Ask DrugCentral

General architecture

Using the assistant

sodium monofluorophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: