nitrogen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4251 7727-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrogen
  • molecular nitrogen
  • nitrogen gas
  • nitrogen, nf
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
  • Molecular weight: 28.01
  • Formula: N2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 47.58
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1180.48 12.07 2300 68565 878655 89678927
Pulmonary arterial hypertension 876.48 12.07 422 70443 25765 90531817
Oxygen saturation decreased 778.32 12.07 656 70209 106827 90450755
Pulmonary hypertension 684.60 12.07 422 70443 42101 90515481
Oxygen consumption increased 532.48 12.07 181 70684 4408 90553174
Right ventricular failure 516.91 12.07 267 70598 18938 90538644
Dyspnoea exertional 493.94 12.07 427 70438 71861 90485721
Respiratory failure 420.14 12.07 490 70375 117928 90439654
Hypoxia 400.86 12.07 380 70485 72019 90485563
Fluid retention 394.64 12.07 412 70453 87679 90469903
Chronic obstructive pulmonary disease 368.36 12.07 366 70499 73463 90484119
Hypervolaemia 329.68 12.07 243 70622 32514 90525068
Drug ineffective 313.49 12.07 375 70490 1383923 89173659
Cough 249.84 12.07 743 70122 368219 90189363
Pain in jaw 243.19 12.07 240 70625 47745 90509837
Pneumonia 237.68 12.07 1057 69808 637002 89920580
Acute respiratory failure 233.15 12.07 223 70642 42695 90514887
Oxygen therapy 226.92 12.07 87 70778 3015 90554567
Glossodynia 223.62 12.07 6 70859 321773 90235809
Arthropathy 221.88 12.07 17 70848 366225 90191357
Transfusion 211.17 12.07 145 70720 17343 90540239
Contraindicated product administered 205.36 12.07 11 70854 320128 90237454
Cardiac failure 201.28 12.07 330 70535 109166 90448416
Hand deformity 200.59 12.07 7 70858 296355 90261227
Epistaxis 196.39 12.07 285 70580 84840 90472742
Productive cough 194.01 12.07 269 70596 76794 90480788
Alopecia 191.36 12.07 74 70791 494997 90062585
Systemic lupus erythematosus 190.67 12.07 28 70837 361868 90195714
Treatment failure 187.23 12.07 13 70852 303915 90253667
Nasal congestion 184.81 12.07 274 70591 83140 90474442
Pulmonary oedema 176.57 12.07 230 70635 61850 90495732
Death 176.23 12.07 765 70100 455786 90101796
Therapeutic product effect decreased 164.96 12.07 14 70851 277557 90280025
Helicobacter infection 162.36 12.07 3 70862 226847 90330735
Oedema peripheral 159.03 12.07 503 70362 257412 90300170
Pericarditis 156.84 12.07 15 70850 270136 90287446
Hypotension 156.42 12.07 584 70281 324813 90232769
Rheumatoid arthritis 156.11 12.07 45 70820 362569 90195013
Psoriatic arthropathy 155.88 12.07 5 70860 228330 90329252
Joint swelling 155.78 12.07 101 70764 503199 90054383
Hepatic enzyme increased 154.87 12.07 45 70820 360691 90196891
Rash 146.33 12.07 249 70616 795851 89761731
Wound 145.22 12.07 30 70835 302950 90254632
Pulmonary arterial pressure increased 139.75 12.07 66 70799 3850 90553732
Infusion related reaction 138.24 12.07 77 70788 416703 90140879
Drug intolerance 138.24 12.07 90 70775 447501 90110081
Haemoglobin increased 137.76 12.07 81 70784 7400 90550182
Syncope 136.72 12.07 313 70552 132350 90425232
Haemoptysis 128.34 12.07 144 70721 33176 90524406
Catheter site erythema 125.80 12.07 66 70799 4828 90552754
Drug hypersensitivity 122.98 12.07 109 70756 463500 90094082
Stomatitis 122.10 12.07 32 70833 274666 90282916
Irritable bowel syndrome 119.12 12.07 12 70853 207436 90350146
Impaired healing 119.03 12.07 20 70845 234179 90323403
Blood pressure decreased 118.18 12.07 211 70654 74684 90482898
Cardiac failure congestive 117.72 12.07 247 70618 98447 90459135
Discomfort 116.28 12.07 35 70830 274300 90283282
Musculoskeletal stiffness 114.99 12.07 44 70821 296488 90261094
Blister 114.68 12.07 29 70836 254969 90302613
Blood cholesterol increased 114.47 12.07 14 70851 207998 90349584
Catheter site pruritus 111.42 12.07 48 70817 2254 90555328
Concomitant disease aggravated 110.38 12.07 83 70782 11435 90546147
Liver injury 105.85 12.07 7 70858 170560 90387022
Chest pain 104.87 12.07 511 70354 319134 90238448
Hypersensitivity 104.50 12.07 121 70744 454556 90103026
Infusion site pain 102.35 12.07 100 70765 19638 90537944
Hypercapnia 101.64 12.07 64 70801 6613 90550969
Pericardial effusion 99.36 12.07 133 70732 36700 90520882
Chest discomfort 98.49 12.07 284 70581 138081 90419501
Headache 97.90 12.07 1067 69798 861679 89695903
Lung transplant 95.50 12.07 50 70815 3642 90553940
Mobility decreased 94.25 12.07 39 70826 250695 90306887
Type 2 diabetes mellitus 93.55 12.07 22 70843 203222 90354360
Palpitations 91.92 12.07 275 70590 136453 90421129
Fibromyalgia 91.70 12.07 24 70841 206245 90351337
Toxicity to various agents 89.99 12.07 57 70808 287789 90269793
Pleural effusion 88.70 12.07 239 70626 111752 90445830
Scleroderma 87.83 12.07 57 70808 6204 90551378
Dependence on oxygen therapy 87.34 12.07 28 70837 564 90557018
Off label use 87.30 12.07 506 70359 1101746 89455836
Flushing 86.98 12.07 205 70660 88286 90469296
Infusion site infection 86.32 12.07 42 70823 2618 90554964
Brain natriuretic peptide increased 85.05 12.07 55 70810 5950 90551632
Urticaria 84.71 12.07 72 70793 312662 90244920
Catheter management 83.94 12.07 43 70822 2993 90554589
Injury 82.13 12.07 26 70839 197323 90360259
Bursitis 79.96 12.07 6 70859 131648 90425934
Intentional product use issue 77.92 12.07 36 70829 216856 90340726
Joint range of motion decreased 77.45 12.07 8 70857 135635 90421947
Respiratory distress 76.44 12.07 121 70744 38825 90518757
Ill-defined disorder 75.80 12.07 25 70840 184866 90372716
Pulmonary veno-occlusive disease 74.21 12.07 32 70833 1506 90556076
Device alarm issue 74.19 12.07 34 70831 1851 90555731
Arthralgia 73.00 12.07 337 70528 778185 89779397
Catheterisation cardiac 71.69 12.07 46 70819 4910 90552672
Dizziness 71.42 12.07 739 70126 588545 89969037
Cyanosis 71.38 12.07 82 70783 19373 90538209
Exercise tolerance decreased 67.05 12.07 52 70813 7499 90550083
Lower respiratory tract infection 65.10 12.07 60 70805 250599 90306983
Psoriasis 64.14 12.07 18 70847 147736 90409846
Product use issue 63.38 12.07 100 70765 329819 90227763
Lip dry 63.05 12.07 4 70861 100951 90456631
Catheter site pain 62.07 12.07 44 70821 5535 90552047
Device related infection 61.86 12.07 88 70777 25698 90531884
Maternal exposure during pregnancy 61.12 12.07 118 70747 359945 90197637
Osteoarthritis 60.82 12.07 39 70826 195691 90361891
Catheter site discharge 60.53 12.07 32 70833 2377 90555205
Unevaluable event 60.47 12.07 133 70732 54715 90502867
Presyncope 59.93 12.07 97 70768 31708 90525874
Anaemia 59.81 12.07 476 70389 352326 90205256
Chronic respiratory failure 59.38 12.07 33 70832 2708 90554874
Cor pulmonale 59.35 12.07 30 70835 2030 90555552
Inflammation 59.12 12.07 33 70832 178559 90379023
Cardiac disorder 57.23 12.07 133 70732 56739 90500843
Therapeutic product effect incomplete 57.08 12.07 41 70824 193855 90363727
Catheter site infection 56.99 12.07 42 70823 5612 90551970
Grip strength decreased 56.84 12.07 4 70861 92572 90465010
Cardiac arrest 55.94 12.07 195 70670 104740 90452842
Cardiac failure acute 55.52 12.07 57 70808 11872 90545710
Heart rate increased 55.25 12.07 204 70661 112698 90444884
Oxygen saturation abnormal 55.20 12.07 37 70828 4251 90553331
C-reactive protein increased 55.19 12.07 37 70828 181352 90376230
Pruritus 55.19 12.07 227 70638 541298 90016284
Orthopnoea 54.11 12.07 44 70821 6791 90550791
Atrial fibrillation 53.73 12.07 227 70638 133384 90424198
Hypercholesterolaemia 52.62 12.07 8 70857 100884 90456698
Swelling 52.46 12.07 161 70704 418897 90138685
Pain 52.23 12.07 513 70352 995828 89561754
Dyspnoea at rest 51.49 12.07 37 70828 4754 90552828
Bronchitis 51.15 12.07 246 70619 152681 90404901
Product dose omission issue 50.76 12.07 396 70469 291291 90266291
Left ventricular failure 50.67 12.07 42 70823 6658 90550924
Feeling abnormal 49.58 12.07 260 70605 166975 90390607
Red blood cell sedimentation rate increased 49.48 12.07 4 70861 82591 90474991
Infusion site erythema 49.11 12.07 57 70808 13613 90543969
Exposure during pregnancy 48.94 12.07 69 70796 238341 90319241
Interstitial lung disease 48.81 12.07 151 70714 76254 90481328
Injection site reaction 48.72 12.07 7 70858 92073 90465509
Sleep disorder 48.40 12.07 50 70815 197980 90359602
Neutropenia 48.28 12.07 63 70802 224841 90332741
Haemoglobin decreased 48.15 12.07 252 70613 161704 90395878
Pulmonary arterial pressure abnormal 47.83 12.07 18 70847 592 90556990
Atrial flutter 47.54 12.07 50 70815 10708 90546874
Hospitalisation 47.20 12.07 212 70653 127888 90429694
Device leakage 46.97 12.07 48 70817 9943 90547639
Subcutaneous emphysema 46.74 12.07 21 70844 1091 90556491
Malaise 46.21 12.07 678 70187 585308 89972274
Prescribed overdose 46.04 12.07 10 70855 97615 90459967
Catheter site rash 46.03 12.07 19 70846 801 90556781
Transplant evaluation 45.93 12.07 22 70843 1324 90556258
Confusional state 45.80 12.07 152 70713 386053 90171529
Abdominal discomfort 45.60 12.07 205 70660 477123 90080459
Air embolism 44.40 12.07 15 70850 358 90557224
Wound infection 44.28 12.07 14 70851 106388 90451194
Pneumothorax 43.91 12.07 64 70801 19103 90538479
Peripheral venous disease 42.98 12.07 7 70858 83914 90473668
Respiratory tract infection 42.72 12.07 122 70743 58956 90498626
Knee arthroplasty 42.46 12.07 7 70858 83175 90474407
Hypoaesthesia 42.01 12.07 117 70748 314093 90243489
Obesity 41.96 12.07 15 70850 105492 90452090
Intentional overdose 41.53 12.07 11 70854 93823 90463759
Night sweats 40.90 12.07 25 70840 128741 90428841
Drug abuse 39.73 12.07 8 70857 82339 90475243
Device connection issue 39.31 12.07 18 70847 978 90556604
Suicide attempt 39.27 12.07 6 70859 75393 90482189
Paraesthesia 39.09 12.07 86 70779 250240 90307342
Pulmonary congestion 38.99 12.07 61 70804 19372 90538210
Ascites 38.90 12.07 103 70762 47637 90509945
Oedema 38.82 12.07 279 70586 200016 90357566
Sepsis 38.10 12.07 256 70609 179558 90378024
Rales 37.94 12.07 54 70811 15773 90541809
Gastrointestinal haemorrhage 37.58 12.07 155 70710 90093 90467489
Device occlusion 37.26 12.07 41 70824 9241 90548341
Pulmonary hypertensive crisis 37.13 12.07 14 70851 463 90557119
Catheter site swelling 36.90 12.07 21 70844 1804 90555778
Device infusion issue 36.76 12.07 24 70841 2638 90554944
Emphysema 36.05 12.07 46 70819 12109 90545473
Autoimmune disorder 35.91 12.07 8 70857 76736 90480846
Gait inability 35.76 12.07 37 70828 146419 90411163
Epilepsy 35.69 12.07 10 70855 82196 90475386
Live birth 35.53 12.07 9 70856 79098 90478484
Thermal burn 34.57 12.07 34 70831 6728 90550854
Hypertension 34.45 12.07 213 70652 457319 90100263
Aspiration pleural cavity 34.42 12.07 16 70849 900 90556682
Catheter site haemorrhage 34.19 12.07 26 70839 3642 90553940
Nasal dryness 34.14 12.07 31 70834 5552 90552030
Platelet count decreased 33.97 12.07 203 70662 136766 90420816
Central venous catheterisation 33.39 12.07 23 70842 2763 90554819
Colitis ulcerative 33.27 12.07 4 70861 60262 90497320
Gastrointestinal disorder 33.25 12.07 97 70768 256590 90300992
Paracentesis 33.16 12.07 16 70849 979 90556603
Oxygen consumption 33.11 12.07 9 70856 99 90557483
Catheter site scab 32.94 12.07 11 70854 253 90557329
Sputum discoloured 32.86 12.07 58 70807 20333 90537249
Gamma-glutamyltransferase increased 32.06 12.07 83 70782 37869 90519713
Cardiac pacemaker insertion 32.03 12.07 27 70838 4380 90553202
Abdominal distension 32.03 12.07 193 70672 130408 90427174
Cardiomegaly 32.02 12.07 55 70810 18870 90538712
Illness 31.97 12.07 138 70727 81831 90475751
Haematocrit decreased 31.82 12.07 88 70777 41744 90515838
Seasonal allergy 31.53 12.07 61 70804 22922 90534660
Product use in unapproved indication 31.13 12.07 146 70719 336090 90221492
Tachypnoea 31.02 12.07 58 70807 21251 90536331
Prescribed underdose 30.99 12.07 10 70855 75009 90482573
Rhinorrhoea 30.92 12.07 144 70721 88172 90469410
Catheter placement 30.63 12.07 21 70844 2503 90555079
Sciatica 30.40 12.07 21 70844 101361 90456221
Apgar score low 30.28 12.07 16 70849 1187 90556395
Gastrointestinal disorder congenital 30.18 12.07 9 70856 141 90557441
Premature baby 30.15 12.07 63 70802 25014 90532568
N-terminal prohormone brain natriuretic peptide increased 29.85 12.07 22 70843 2940 90554642
Oedematous kidney 29.83 12.07 9 70856 147 90557435
Bladder agenesis 29.66 12.07 9 70856 150 90557432
Supraventricular tachycardia 29.66 12.07 49 70816 16287 90541295
Pulmonary function test decreased 29.55 12.07 26 70839 4468 90553114
Depression 29.34 12.07 128 70737 300473 90257109
Cloacal exstrophy 29.28 12.07 9 70856 157 90557425
Genitalia external ambiguous 29.28 12.07 9 70856 157 90557425
Chills 29.22 12.07 190 70675 131791 90425791
Throat irritation 29.05 12.07 94 70771 48601 90508981
Vascular device infection 28.98 12.07 41 70824 11911 90545671
Congenital genital malformation 28.92 12.07 9 70856 164 90557418
Blood iron decreased 28.83 12.07 51 70814 17908 90539674
Loss of consciousness 28.71 12.07 198 70667 140040 90417542
Carbon dioxide increased 28.61 12.07 18 70847 1857 90555725
Respiratory syncytial virus infection 28.50 12.07 38 70827 10442 90547140
General physical health deterioration 28.48 12.07 162 70703 354953 90202629
Foot deformity 28.35 12.07 6 70859 59645 90497937
Hepatitis 28.22 12.07 10 70855 70729 90486853
Exostosis 28.20 12.07 4 70861 53130 90504452
Congenital ectopic bladder 28.14 12.07 8 70857 105 90557477
Secretion discharge 27.95 12.07 47 70818 15849 90541733
Adverse drug reaction 27.91 12.07 30 70835 116671 90440911
Nocturnal dyspnoea 27.59 12.07 16 70849 1424 90556158
Walking distance test abnormal 27.51 12.07 12 70853 581 90557001
Injection site erythema 27.48 12.07 22 70843 98480 90459102
Bronchospasm 27.24 12.07 54 70811 20655 90536927
Congestive hepatopathy 27.17 12.07 21 70844 3012 90554570
Right ventricular dysfunction 27.12 12.07 19 70846 2345 90555237
Gastrointestinal malformation 27.12 12.07 9 70856 203 90557379
Aspartate aminotransferase increased 27.10 12.07 155 70710 102782 90454800
Meconium stain 27.03 12.07 9 70856 205 90557377
Pneumonia bacterial 26.86 12.07 41 70824 12749 90544833
Lipodystrophy acquired 26.85 12.07 16 70849 1498 90556084
Hip arthroplasty 26.81 12.07 13 70852 76195 90481387
Anaesthetic complication 26.41 12.07 19 70846 2446 90555136
Localised oedema 25.98 12.07 28 70837 6166 90551416
Gout 25.94 12.07 47 70818 16812 90540770
Weight decreased 25.85 12.07 429 70436 379481 90178101
Neuromuscular blockade 25.82 12.07 10 70855 356 90557226
Taste disorder 25.78 12.07 8 70857 61538 90496044
Disease progression 25.77 12.07 210 70655 156405 90401177
Pulseless electrical activity 25.23 12.07 33 70832 8899 90548683
Cardiac ablation 25.10 12.07 16 70849 1688 90555894
Stent placement 25.04 12.07 23 70842 4180 90553402
Pneumomediastinum 24.89 12.07 17 70848 2014 90555568
Pulmonary haemorrhage 24.84 12.07 31 70834 7982 90549600
Pregnancy 24.37 12.07 9 70856 62038 90495544
Tethered cord syndrome 24.24 12.07 9 70856 285 90557297
Dry mouth 24.24 12.07 69 70796 183990 90373592
Caudal regression syndrome 23.68 12.07 8 70857 191 90557391
Concomitant disease progression 23.44 12.07 17 70848 2215 90555367
Febrile neutropenia 23.42 12.07 56 70809 158293 90399289
Device maintenance issue 23.40 12.07 8 70857 198 90557384
Neural tube defect 23.33 12.07 8 70857 200 90557382
Idiopathic pulmonary fibrosis 23.26 12.07 15 70850 1615 90555967
Rehabilitation therapy 22.96 12.07 16 70849 1958 90555624
Pulmonary trichosporonosis 22.96 12.07 6 70859 56 90557526
Upper respiratory tract inflammation 22.86 12.07 18 70847 2654 90554928
Cognitive disorder 22.71 12.07 13 70852 69394 90488188
Complication associated with device 22.39 12.07 48 70817 19401 90538181
Increased ventricular preload 22.36 12.07 5 70860 22 90557560
Iron deficiency anaemia 22.35 12.07 54 70811 23608 90533974
Dermatitis contact 22.33 12.07 39 70826 13556 90544026
Coeliac disease 22.23 12.07 4 70861 44606 90512976
Joint dislocation 22.21 12.07 4 70861 44578 90513004
Hepatic function abnormal 22.10 12.07 83 70782 46205 90511377
Tachycardia 22.07 12.07 204 70661 157469 90400113
Mediastinal effusion 21.67 12.07 6 70859 71 90557511
Argon plasma coagulation 21.67 12.07 5 70860 26 90557556
Pulmonary alveolar haemorrhage 21.53 12.07 25 70840 5973 90551609
Blood potassium decreased 21.49 12.07 84 70781 47643 90509939
Suicidal ideation 21.23 12.07 16 70849 73839 90483743
Ventilation perfusion mismatch 21.19 12.07 10 70855 582 90557000
Infusion site swelling 21.07 12.07 35 70830 11685 90545897
Fall 21.02 12.07 509 70356 481301 90076281
Rhinocerebral mucormycosis 21.01 12.07 11 70854 801 90556781
Lung adenocarcinoma stage IV 20.53 12.07 9 70856 441 90557141
Anal atresia 20.53 12.07 9 70856 441 90557141
Pancreatitis haemorrhagic 20.32 12.07 10 70855 639 90556943
Cardiac failure high output 20.26 12.07 9 70856 455 90557127
Infusion site haemorrhage 20.17 12.07 23 70842 5388 90552194
Tricuspid valve incompetence 20.08 12.07 42 70823 16689 90540893
Bradycardia 19.98 12.07 123 70742 83724 90473858
Infusion site discharge 19.96 12.07 16 70849 2419 90555163
Terminal state 19.94 12.07 17 70848 2801 90554781
Pulmonary artery banding 19.62 12.07 4 70861 10 90557572
Craniotomy 19.43 12.07 8 70857 335 90557247
Acute postoperative sialadenitis 19.20 12.07 5 70860 46 90557536
Musculoskeletal pain 19.19 12.07 69 70796 171182 90386400
Rhonchi 19.13 12.07 17 70848 2961 90554621
Hyperandrogenism 18.99 12.07 6 70859 115 90557467
Blood immunoglobulin E 18.91 12.07 5 70860 49 90557533
Pulmonary capillary haemangiomatosis 18.91 12.07 5 70860 49 90557533
Amnesia 18.87 12.07 35 70830 108470 90449112
PO2 decreased 18.83 12.07 13 70852 1568 90556014
Lung assist device therapy 18.80 12.07 6 70859 119 90557463
Pulmonary artery dilatation 18.79 12.07 8 70857 365 90557217
Accident 18.58 12.07 25 70840 6929 90550653
Oedematous pancreatitis 18.52 12.07 10 70855 775 90556807
Road traffic accident 18.47 12.07 35 70830 107591 90449991
Head injury 18.41 12.07 60 70805 31128 90526454
Middle ear effusion 18.41 12.07 16 70849 2705 90554877
Heart rate irregular 18.41 12.07 51 70814 24217 90533365
Influenza 18.40 12.07 178 70687 139086 90418496
Pulmonary nocardiosis 18.37 12.07 10 70855 788 90556794
Anencephaly 18.29 12.07 8 70857 390 90557192
Right ventricular systolic pressure increased 18.13 12.07 9 70856 586 90556996
Apnoea 18.13 12.07 29 70836 9385 90548197
Cardioversion 18.07 12.07 12 70853 1358 90556224
Leukopenia 17.95 12.07 32 70833 100678 90456904
Sepsis neonatal 17.87 12.07 9 70856 604 90556978
Breath sounds abnormal 17.74 12.07 38 70827 15348 90542234
Platelet transfusion 17.71 12.07 11 70854 1109 90556473
Enlarged clitoris 17.69 12.07 6 70859 145 90557437
Diarrhoea 17.61 12.07 900 69965 938290 89619292
Blood urea increased 17.50 12.07 58 70807 30355 90527227
Meningomyelocele 17.48 12.07 9 70856 633 90556949
Hospice care 17.47 12.07 29 70836 9675 90547907
Angioedema 17.46 12.07 15 70850 64861 90492721
Uterine hypotonus 17.35 12.07 6 70859 154 90557428
Increased bronchial secretion 17.34 12.07 14 70851 2139 90555443
Abdominal cavity drainage 17.18 12.07 8 70857 452 90557130
Limb injury 17.17 12.07 59 70806 31449 90526133
Injection site swelling 17.15 12.07 13 70852 59826 90497756
Umbilical cord abnormality 16.97 12.07 9 70856 673 90556909
Choking sensation 16.85 12.07 18 70847 3924 90553658
Multiple sclerosis relapse 16.82 12.07 10 70855 52295 90505287
Haematocrit increased 16.72 12.07 16 70849 3062 90554520
Red blood cell count decreased 16.53 12.07 76 70789 46275 90511307
Oxygen consumption decreased 16.47 12.07 7 70858 318 90557264
Systemic scleroderma 16.46 12.07 12 70853 1577 90556005
Tracheostomy 16.43 12.07 9 70856 718 90556864
Cold burn 16.39 12.07 3 70862 3 90557579
Procedural hypotension 16.38 12.07 12 70853 1588 90555994
Finger deformity 16.28 12.07 3 70862 32894 90524688
Lower limb fracture 16.08 12.07 26 70839 84987 90472595
Liver function test increased 16.00 12.07 26 70839 84829 90472753
Echocardiogram 15.97 12.07 4 70861 31 90557551
Laryngitis 15.91 12.07 10 70855 50743 90506839
Infection 15.85 12.07 194 70671 361900 90195682
Drug-induced liver injury 15.82 12.07 29 70836 90289 90467293
Device wireless communication issue 15.82 12.07 5 70860 96 90557486
Dysbiosis 15.72 12.07 12 70853 1690 90555892
Vasodilatation 15.68 12.07 15 70850 2869 90554713
Exomphalos 15.56 12.07 8 70857 561 90557021
Infusion site abscess 15.50 12.07 7 70858 368 90557214
Multiple organ dysfunction syndrome 15.50 12.07 99 70766 68237 90489345
Gastrointestinal arteriovenous malformation 15.48 12.07 8 70857 567 90557015
Dialysis 15.46 12.07 30 70835 11299 90546283
Jugular vein distension 15.45 12.07 10 70855 1083 90556499
Faeces discoloured 15.38 12.07 44 70821 21276 90536306
Sputum increased 15.36 12.07 15 70850 2942 90554640
Catheter site hypersensitivity 15.36 12.07 5 70860 106 90557476
Catheter site warmth 15.33 12.07 6 70859 220 90557362
Cellulitis 15.30 12.07 123 70742 91214 90466368
Retching 15.26 12.07 41 70824 19118 90538464
Therapy change 15.16 12.07 25 70840 8297 90549285
Blood alkaline phosphatase increased 15.10 12.07 76 70789 48003 90509579
Atrioventricular block second degree 15.06 12.07 18 70847 4434 90553148
Medication error 14.99 12.07 27 70838 84625 90472957
Device use error 14.95 12.07 23 70842 7198 90550384
Meningitis cryptococcal 14.93 12.07 12 70853 1821 90555761
Dizziness postural 14.91 12.07 26 70839 9027 90548555
Catheter site vesicles 14.91 12.07 7 70858 403 90557179
Malignant neoplasm progression 14.86 12.07 39 70826 106831 90450751
Liver disorder 14.85 12.07 47 70818 121222 90436360
Acute right ventricular failure 14.83 12.07 6 70859 240 90557342
Paradoxical embolism 14.71 12.07 4 70861 44 90557538
Mucosal inflammation 14.70 12.07 14 70851 57611 90499971
Biopsy liver 14.67 12.07 7 70858 418 90557164
Pulmonary pain 14.61 12.07 19 70846 5095 90552487
Respiration abnormal 14.61 12.07 24 70841 7939 90549643
Upper respiratory tract infection 14.56 12.07 159 70706 128159 90429423
Atelectasis 14.45 12.07 47 70818 24362 90533220
Urine output decreased 14.39 12.07 31 70834 12572 90545010
Device failure 14.33 12.07 22 70843 6875 90550707
Stress cardiomyopathy 14.28 12.07 32 70833 13323 90544259
Immunodeficiency 14.28 12.07 8 70857 43226 90514356
Oropharyngeal pain 14.13 12.07 145 70720 115042 90442540
Catheter site inflammation 14.13 12.07 9 70856 948 90556634
Decreased activity 14.11 12.07 24 70841 8168 90549414
Contusion 14.08 12.07 127 70738 251089 90306493
Toxic epidermal necrolysis 14.04 12.07 4 70861 32524 90525058
Injection site pain 14.03 12.07 79 70786 173620 90383962
Device related sepsis 14.00 12.07 18 70847 4775 90552807
Respiratory tract haemorrhage 13.95 12.07 7 70858 466 90557116
Disease recurrence 13.90 12.07 6 70859 37647 90519935
Stevens-Johnson syndrome 13.87 12.07 3 70862 29373 90528209
Joint stiffness 13.72 12.07 25 70840 78017 90479565
Compartment syndrome 13.71 12.07 14 70851 2898 90554684
Overdose 13.70 12.07 70 70795 157639 90399943
Neoplasm progression 13.62 12.07 9 70856 44477 90513105
Osteoporosis 13.59 12.07 35 70830 96496 90461086
Right ventricular dilatation 13.58 12.07 11 70854 1688 90555894
Vascular cauterisation 13.58 12.07 4 70861 60 90557522
Pulmonary thrombosis 13.46 12.07 26 70839 9756 90547826
Post procedural complication 13.45 12.07 39 70826 19003 90538579
Administration site pruritus 13.40 12.07 6 70859 309 90557273
Burns third degree 13.39 12.07 6 70859 310 90557272
Asthenia 13.37 12.07 527 70338 533224 90024358
Mastitis bacterial 13.34 12.07 4 70861 64 90557518
Device issue 13.30 12.07 52 70813 29485 90528097
Catheter site erosion 13.28 12.07 4 70861 65 90557517
Osteonecrosis of jaw 13.26 12.07 7 70858 39096 90518486
Dizziness exertional 13.18 12.07 7 70858 525 90557057
Gastric dilatation 13.17 12.07 10 70855 1397 90556185
Swollen tongue 13.15 12.07 10 70855 45946 90511636
Choking 13.06 12.07 29 70836 12004 90545578
Lung squamous cell carcinoma stage I 12.94 12.07 3 70862 16 90557566
Renal failure 12.93 12.07 158 70707 130849 90426733
Right ventricular hypertrophy 12.86 12.07 8 70857 809 90556773
Unevaluable device issue 12.79 12.07 3 70862 17 90557565
Brain hypoxia 12.74 12.07 7 70858 562 90557020
Nausea 12.73 12.07 1020 69845 1109296 89448286
Myalgia 12.73 12.07 200 70665 174925 90382657
Renal disorder 12.71 12.07 61 70804 37798 90519784
Alanine aminotransferase increased 12.68 12.07 145 70720 118193 90439389
Upper-airway cough syndrome 12.68 12.07 33 70832 15102 90542480
Agonal respiration 12.68 12.07 5 70860 187 90557395
Sinus disorder 12.67 12.07 57 70808 34390 90523192
Oxygen saturation increased 12.67 12.07 6 70859 352 90557230
Hypoacusis 12.52 12.07 49 70816 27801 90529781
Neutrophil count decreased 12.50 12.07 23 70842 71509 90486073
Lung infiltration 12.48 12.07 33 70832 15249 90542333
Blood bilirubin increased 12.47 12.07 67 70798 43403 90514179
Muscle spasticity 12.46 12.07 6 70859 35316 90522266
Mouth ulceration 12.36 12.07 8 70857 39966 90517616
Rhinovirus infection 12.36 12.07 19 70846 5944 90551638
Spina bifida 12.32 12.07 8 70857 872 90556710
Back injury 12.28 12.07 11 70854 46611 90510971
Therapeutic response decreased 12.28 12.07 33 70832 89696 90467886
Candida infection 12.26 12.07 56 70809 34001 90523581
Patient dissatisfaction with device 12.23 12.07 4 70861 86 90557496
CREST syndrome 12.21 12.07 7 70858 610 90556972
Coma 12.13 12.07 24 70841 72608 90484974
Catheter removal 12.12 12.07 6 70859 388 90557194

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 420.91 12.14 1055 34892 441566 42143822
Oxygen saturation decreased 369.45 12.14 357 35590 64330 42521058
Pulmonary arterial hypertension 343.42 12.14 169 35778 10018 42575370
Hypoxia 264.79 12.14 310 35637 69476 42515912
Right ventricular failure 217.75 12.14 122 35825 9433 42575955
Pulmonary hypertension 204.37 12.14 165 35782 23404 42561984
Respiratory failure 201.88 12.14 376 35571 127756 42457632
Oxygen consumption increased 178.31 12.14 63 35884 1596 42583792
Chronic obstructive pulmonary disease 140.14 12.14 216 35731 62898 42522490
Fluid retention 135.96 12.14 150 35797 31469 42553919
Pneumonia 120.15 12.14 684 35263 421465 42163923
Idiopathic pulmonary fibrosis 116.48 12.14 63 35884 4541 42580847
Acute respiratory failure 112.65 12.14 151 35796 38707 42546681
Concomitant disease aggravated 110.45 12.14 69 35878 6517 42578871
Dyspnoea exertional 95.37 12.14 160 35787 49988 42535400
Pain in jaw 86.32 12.14 82 35865 14420 42570968
Brain scan abnormal 81.99 12.14 33 35914 1206 42584182
Cerebral artery thrombosis 81.74 12.14 33 35914 1216 42584172
Cough 78.81 12.14 328 35619 177775 42407613
Hypervolaemia 76.59 12.14 96 35851 23029 42562359
Toxicity to various agents 75.94 12.14 50 35897 229086 42356302
Respiratory distress 72.38 12.14 128 35819 41692 42543696
Drug ineffective 65.42 12.14 292 35655 629905 41955483
Thermal burn 65.34 12.14 37 35910 2917 42582471
Pulmonary oedema 59.67 12.14 136 35811 53136 42532252
Completed suicide 57.27 12.14 7 35940 96458 42488930
Transfusion 56.10 12.14 56 35891 10458 42574930
Nasal congestion 55.89 12.14 94 35853 29407 42555981
Areflexia 54.79 12.14 36 35911 3707 42581681
Oxygen therapy 53.23 12.14 25 35922 1333 42584055
Haemoglobin increased 52.78 12.14 40 35907 5166 42580222
Pneumothorax 51.39 12.14 80 35867 23463 42561925
Pulmonary arterial pressure increased 50.27 12.14 25 35922 1513 42583875
Drug abuse 46.84 12.14 15 35932 104756 42480632
Hypercapnia 45.31 12.14 37 35910 5324 42580064
Neutropenia 44.48 12.14 62 35885 199369 42386019
Oedema 42.72 12.14 118 35829 51883 42533505
Blood pressure decreased 38.98 12.14 123 35824 58209 42527179
Haemoptysis 38.16 12.14 105 35842 46062 42539326
Brain natriuretic peptide increased 37.87 12.14 37 35910 6733 42578655
Lung transplant 37.51 12.14 24 35923 2362 42583026
Cardiac arrest 34.77 12.14 183 35764 109137 42476251
Emphysema 34.28 12.14 46 35901 11789 42573599
Neuromuscular block prolonged 32.57 12.14 14 35933 605 42584783
Pulmonary veno-occlusive disease 32.33 12.14 14 35933 616 42584772
Productive cough 31.98 12.14 106 35841 51461 42533927
Respiratory tract infection 31.48 12.14 69 35878 26253 42559135
Catheter management 31.46 12.14 16 35931 1016 42584372
Subcutaneous emphysema 31.44 12.14 19 35928 1690 42583698
Chronic respiratory failure 31.31 12.14 19 35928 1703 42583685
Oedema peripheral 31.17 12.14 209 35738 135867 42449521
Hemiplegia 29.81 12.14 35 35912 7844 42577544
Cardiac failure 28.74 12.14 171 35776 106685 42478703
Cor pulmonale 28.67 12.14 14 35933 814 42584574
Epistaxis 28.63 12.14 122 35825 66704 42518684
Ventilation perfusion mismatch 28.40 12.14 9 35938 161 42585227
Catheter site erythema 28.28 12.14 18 35929 1755 42583633
Hypotension 27.94 12.14 336 35611 257295 42328093
Pulmonary fibrosis 27.55 12.14 66 35881 26615 42558773
Cyanosis 27.28 12.14 47 35900 14984 42570404
Catheter placement 26.92 12.14 14 35933 931 42584457
Catheter site haemorrhage 26.77 12.14 20 35927 2528 42582860
Mechanical ventilation 26.47 12.14 19 35928 2258 42583130
Catheter removal 26.41 12.14 9 35938 204 42585184
COVID-19 pneumonia 26.23 12.14 57 35890 21556 42563832
Treatment failure 26.20 12.14 10 35937 62614 42522774
Pulmonary function test decreased 26.02 12.14 28 35919 5704 42579684
Intentional overdose 25.55 12.14 6 35941 51450 42533938
Respiratory acidosis 25.42 12.14 29 35918 6302 42579086
Pneumomediastinum 25.28 12.14 21 35926 3095 42582293
Rhinocerebral mucormycosis 24.90 12.14 12 35935 678 42584710
Transplant evaluation 24.82 12.14 11 35936 512 42584876
Disseminated strongyloidiasis 24.74 12.14 11 35936 516 42584872
White blood cell count decreased 23.91 12.14 35 35912 110361 42475027
Pulmonary haemorrhage 23.86 12.14 38 35909 11359 42574029
Headache 23.72 12.14 307 35640 239062 42346326
Pulmonary function test abnormal 23.63 12.14 19 35928 2675 42582713
Carbon dioxide increased 23.04 12.14 14 35933 1258 42584130
Catheterisation cardiac 23.02 12.14 19 35928 2775 42582613
Lung disorder 22.50 12.14 90 35857 47833 42537555
Stress 22.26 12.14 5 35942 44207 42541181
Infusion site pain 22.15 12.14 25 35922 5370 42580018
Respiratory disorder 22.12 12.14 54 35893 22031 42563357
Pulmonary congestion 22.03 12.14 44 35903 15686 42569702
Dependence on oxygen therapy 21.82 12.14 8 35939 226 42585162
Therapeutic product effect incomplete 21.47 12.14 17 35930 70922 42514466
Air embolism 21.33 12.14 8 35939 241 42585147
Drug interaction 21.23 12.14 135 35812 266864 42318524
Bronchopulmonary aspergillosis 21.07 12.14 49 35898 19380 42566008
Subacute combined cord degeneration 21.00 12.14 7 35940 148 42585240
Confusional state 20.85 12.14 72 35875 167525 42417863
Interstitial lung disease 20.72 12.14 125 35822 78337 42507051
Cardiac failure congestive 20.51 12.14 133 35814 85469 42499919
Condition aggravated 20.46 12.14 321 35626 260433 42324955
Hyponatraemia 20.23 12.14 34 35913 101428 42483960
Catheter site discharge 20.06 12.14 11 35936 814 42584574
Haemodynamic instability 19.89 12.14 37 35910 12520 42572868
Abdominal pain 19.76 12.14 88 35859 190383 42395005
Walking distance test abnormal 19.71 12.14 7 35940 180 42585208
Oxygen saturation abnormal 19.66 12.14 15 35932 1956 42583432
PaO2/FiO2 ratio decreased 19.55 12.14 5 35942 39 42585349
Catheter site granuloma 19.44 12.14 5 35942 40 42585348
Complication associated with device 19.40 12.14 26 35921 6655 42578733
Catheter site pain 19.29 12.14 14 35933 1693 42583695
Apnoea 19.13 12.14 28 35919 7775 42577613
Pulmonary hypertensive crisis 18.98 12.14 7 35940 201 42585187
Catheter site pruritus 18.92 12.14 8 35939 332 42585056
Infusion site erythema 18.79 12.14 19 35928 3603 42581785
Coma 18.65 12.14 11 35936 53543 42531845
Facial paralysis 18.64 12.14 36 35911 12527 42572861
Rotavirus infection 18.60 12.14 9 35938 513 42584875
Burns third degree 18.60 12.14 7 35940 213 42585175
Aggression 18.56 12.14 7 35940 44156 42541232
Bradycardia 18.19 12.14 129 35818 85355 42500033
Tracheal injury 18.02 12.14 5 35942 55 42585333
Dyspnoea at rest 17.98 12.14 20 35927 4229 42581159
Acute right ventricular failure 17.69 12.14 6 35941 134 42585254
Malassezia infection 17.62 12.14 5 35942 60 42585328
Rash maculo-papular 17.42 12.14 5 35942 37498 42547890
Rheumatoid arthritis 17.38 12.14 7 35940 42433 42542955
Flushing 16.95 12.14 69 35878 36959 42548429
Cardiac assistance device user 16.78 12.14 5 35942 72 42585316
Tachypnoea 16.65 12.14 48 35899 21614 42563774
Anaesthetic complication 16.58 12.14 12 35935 1445 42583943
Delayed recovery from anaesthesia 16.52 12.14 11 35936 1158 42584230
Procedural complication 16.39 12.14 19 35928 4200 42581188
Thyroglobulin increased 16.28 12.14 4 35943 26 42585362
Thrombocytopenia 16.26 12.14 94 35853 190185 42395203
Infusion site vesicles 16.21 12.14 6 35941 174 42585214
Pneumonia cryptococcal 16.21 12.14 12 35935 1496 42583892
Hyperoxia 16.16 12.14 3 35944 3 42585385
Anaesthetic complication cardiac 15.90 12.14 4 35943 29 42585359
Superinfection fungal 15.78 12.14 4 35943 30 42585358
Hyperthermia malignant 15.76 12.14 15 35932 2643 42582745
Alkalosis hypochloraemic 15.75 12.14 7 35940 328 42585060
Pulse pressure decreased 15.75 12.14 6 35941 189 42585199
Thoracic cavity drainage 15.69 12.14 6 35941 191 42585197
Catheter site infection 15.68 12.14 16 35931 3067 42582321
Syncope 15.67 12.14 140 35807 99266 42486122
Cytomegalovirus infection 15.58 12.14 4 35943 32302 42553086
Accident 15.46 12.14 23 35924 6480 42578908
Heart rate increased 15.46 12.14 87 35860 53168 42532220
Bronchopulmonary dysplasia 15.45 12.14 9 35938 748 42584640
Bifidobacterium infection 15.45 12.14 5 35942 96 42585292
SARS-CoV-2 viraemia 15.45 12.14 5 35942 96 42585292
Catheter site warmth 15.35 12.14 5 35942 98 42585290
Suicide attempt 15.31 12.14 10 35937 46090 42539298
Barotrauma 15.24 12.14 4 35943 35 42585353
Tubulointerstitial nephritis 15.04 12.14 4 35943 31544 42553844
Acute kidney injury 14.96 12.14 219 35728 367118 42218270
Rectal haemorrhage 14.86 12.14 12 35935 49594 42535794
Nasal dryness 14.75 12.14 11 35936 1386 42584002
Mucosal inflammation 14.72 12.14 12 35935 49362 42536026
Febrile neutropenia 14.69 12.14 94 35853 185609 42399779
Catheter site rash 14.66 12.14 6 35941 229 42585159
Infusion site irritation 14.63 12.14 7 35940 389 42584999
Decompression sickness 14.63 12.14 3 35944 7 42585381
Bronchospasm 14.53 12.14 33 35914 12852 42572536
Psoriasis 14.26 12.14 12 35935 48592 42536796
Electrocardiogram ST segment elevation 14.11 12.14 21 35926 5918 42579470
Catheter site inflammation 14.03 12.14 6 35941 256 42585132
Suicidal ideation 14.00 12.14 12 35935 48149 42537239
Lung infiltration 13.79 12.14 34 35913 13955 42571433
Accidental underdose 13.76 12.14 8 35939 663 42584725
Hallucination 13.69 12.14 17 35930 57490 42527898
Therapeutic product effect decreased 13.69 12.14 8 35939 39142 42546246
Pulmonary alveolar haemorrhage 13.55 12.14 35 35912 14781 42570607
Pulseless electrical activity 13.53 12.14 25 35922 8412 42576976
Blood cholesterol increased 13.51 12.14 3 35944 26738 42558650
Intentional product use issue 13.47 12.14 25 35922 71808 42513580
Bronchial haemorrhage 13.40 12.14 8 35939 696 42584692
Device intolerance 13.23 12.14 3 35944 13 42585375
Rash 13.12 12.14 160 35787 276794 42308594
Off label use 13.06 12.14 425 35522 637910 41947478
Stomatitis 12.93 12.14 14 35933 50315 42535073
Rheumatoid arthritis-associated interstitial lung disease 12.87 12.14 3 35944 15 42585373
Neutrophil count decreased 12.87 12.14 21 35926 63394 42521994
Device related infection 12.85 12.14 42 35905 20237 42565151
Pulmonary artery dilatation 12.84 12.14 6 35941 316 42585072
Agranulocytosis 12.62 12.14 5 35942 30607 42554781
Malignant neoplasm progression 12.52 12.14 48 35899 108352 42477036
Myotonic dystrophy 12.41 12.14 5 35942 183 42585205
Weight decreased 12.35 12.14 245 35702 207703 42377685
Aspartate aminotransferase increased 12.32 12.14 109 35838 77054 42508334
Pneumonia bacterial 12.28 12.14 35 35912 15657 42569731
Cardiac failure acute 12.26 12.14 32 35915 13601 42571787
Therapy non-responder 12.22 12.14 82 35865 53277 42532111
Psoriatic arthropathy 12.22 12.14 3 35944 24964 42560424
BRASH syndrome 12.17 12.14 11 35936 1814 42583574

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1289.68 11.28 2819 88528 1104053 109393899
Pulmonary arterial hypertension 1099.01 11.28 537 90810 32031 110465921
Oxygen saturation decreased 974.66 11.28 899 90448 156083 110341869
Pulmonary hypertension 758.40 11.28 506 90841 54714 110443238
Oxygen consumption increased 642.85 11.28 223 91124 5462 110492490
Right ventricular failure 632.77 11.28 344 91003 25610 110472342
Hypoxia 574.29 11.28 618 90729 128897 110369055
Fluid retention 521.58 11.28 507 90840 93800 110404152
Dyspnoea exertional 486.83 11.28 511 90836 103549 110394403
Respiratory failure 457.80 11.28 714 90633 214618 110283334
Hypervolaemia 359.49 11.28 310 91037 49150 110448802
Chronic obstructive pulmonary disease 359.48 11.28 447 90900 108711 110389241
Pain in jaw 295.76 11.28 282 91065 50895 110447057
Acute respiratory failure 286.78 11.28 332 91015 74928 110423024
Pneumonia 275.43 11.28 1438 89909 875276 109622676
Drug ineffective 245.51 11.28 561 90786 1519979 108977973
Transfusion 242.73 11.28 187 91160 25285 110472667
Cough 218.75 11.28 856 90491 460785 110037167
Oxygen therapy 210.79 11.28 91 91256 4062 110493890
Nasal congestion 208.72 11.28 326 91021 97956 110399996
Pulmonary oedema 204.26 11.28 327 91020 100332 110397620
Concomitant disease aggravated 191.59 11.28 136 91211 16228 110481724
Completed suicide 169.94 11.28 7 91340 242374 110255578
Oedema peripheral 169.18 11.28 626 90721 328034 110169918
Toxicity to various agents 166.60 11.28 95 91252 480460 110017492
Arthropathy 163.41 11.28 22 91325 287500 110210452
Cardiac failure 161.15 11.28 427 90920 187199 110310753
Treatment failure 160.48 11.28 20 91327 277214 110220738
Hand deformity 154.23 11.28 6 91341 218500 110279452
Therapeutic product effect decreased 153.35 11.28 13 91334 244303 110253649
Productive cough 152.03 11.28 309 91038 113996 110383956
Glossodynia 150.49 11.28 8 91339 221996 110275956
Epistaxis 149.76 11.28 332 91015 130040 110367912
Pulmonary arterial pressure increased 147.70 11.28 76 91271 5051 110492901
Psoriatic arthropathy 143.85 11.28 4 91343 196757 110301195
Catheter site erythema 141.62 11.28 78 91269 5950 110492002
Blood pressure decreased 141.21 11.28 301 91046 114790 110383162
Contraindicated product administered 136.40 11.28 21 91326 248246 110249706
Hypotension 134.52 11.28 815 90532 523034 109974918
Pericarditis 133.91 11.28 13 91334 219101 110278851
Rheumatoid arthritis 133.01 11.28 41 91306 299572 110198380
Duodenal ulcer perforation 132.22 11.28 3 91344 177697 110320255
Alopecia 130.88 11.28 69 91278 364684 110133268
Respiratory distress 130.55 11.28 217 91130 68657 110429295
Systemic lupus erythematosus 129.95 11.28 26 91321 254312 110243640
Haemoptysis 123.61 11.28 216 91131 71138 110426814
Syncope 120.68 11.28 405 90942 202131 110295821
Lung transplant 120.35 11.28 67 91280 5219 110492733
Drug intolerance 119.89 11.28 96 91251 406416 110091536
Catheter site pruritus 118.58 11.28 51 91296 2255 110495697
Hypercapnia 117.55 11.28 87 91260 11072 110486880
Stomatitis 116.37 11.28 39 91308 270203 110227749
Brain natriuretic peptide increased 114.97 11.28 86 91261 11123 110486829
Helicobacter infection 113.24 11.28 10 91337 181867 110316085
Hepatic enzyme increased 113.21 11.28 62 91285 320830 110177122
Death 108.94 11.28 965 90382 697904 109800048
Rash 106.12 11.28 337 91010 820627 109677325
Blood cholesterol increased 105.29 11.28 14 91333 184771 110313181
Drug hypersensitivity 104.51 11.28 133 91214 453957 110043995
Infusion related reaction 103.90 11.28 97 91250 381065 110116887
Chest pain 102.57 11.28 595 90752 375780 110122172
Joint swelling 101.61 11.28 130 91217 442715 110055237
Pulmonary veno-occlusive disease 99.06 11.28 44 91303 2104 110495848
Headache 98.38 11.28 1137 90210 881240 109616712
Catheter management 97.98 11.28 52 91295 3683 110494269
Irritable bowel syndrome 97.09 11.28 11 91336 164204 110333748
Cardiac failure congestive 96.24 11.28 309 91038 150691 110347261
Neutropenia 95.59 11.28 101 91246 374519 110123433
Impaired healing 94.63 11.28 23 91324 196694 110301258
Musculoskeletal stiffness 91.73 11.28 59 91288 279763 110218189
Catheterisation cardiac 90.42 11.28 59 91288 6132 110491820
Intentional product use issue 90.22 11.28 46 91301 247860 110250092
Idiopathic pulmonary fibrosis 88.92 11.28 54 91293 4950 110493002
Drug abuse 88.82 11.28 19 91328 177392 110320560
Pericardial effusion 86.14 11.28 163 91184 57054 110440898
Cyanosis 85.58 11.28 114 91233 29627 110468325
Pleural effusion 84.31 11.28 330 91017 177379 110320573
Fibromyalgia 84.15 11.28 19 91328 170890 110327062
Wound 83.10 11.28 45 91302 234392 110263560
Hypersensitivity 82.33 11.28 129 91218 403869 110094083
Mobility decreased 82.09 11.28 47 91300 237375 110260577
Scleroderma 81.94 11.28 56 91291 6285 110491667
Bursitis 81.26 11.28 7 91340 129911 110368041
Infusion site pain 80.40 11.28 85 91262 17334 110480618
Dependence on oxygen therapy 80.34 11.28 28 91319 695 110497257
Urticaria 80.18 11.28 87 91260 318770 110179182
Liver injury 79.74 11.28 14 91333 150399 110347553
Catheter site discharge 79.63 11.28 42 91305 2937 110495015
Flushing 78.60 11.28 227 91120 104509 110393443
Type 2 diabetes mellitus 77.29 11.28 25 91322 177207 110320745
Blister 77.21 11.28 46 91301 227330 110270622
Thermal burn 76.87 11.28 59 91288 7929 110490023
Brain scan abnormal 75.09 11.28 33 91314 1538 110496414
Pneumothorax 74.80 11.28 117 91230 35168 110462784
Chronic respiratory failure 74.23 11.28 44 91303 3859 110494093
Catheter site pain 74.13 11.28 53 91294 6393 110491559
Joint range of motion decreased 72.42 11.28 8 91339 121824 110376128
Chest discomfort 72.31 11.28 310 91037 173538 110324414
Oedema 72.19 11.28 354 90993 209622 110288330
Unevaluable event 71.58 11.28 154 91193 59073 110438879
Discomfort 70.73 11.28 45 91302 214662 110283290
Catheter site infection 70.30 11.28 56 91291 7944 110490008
Cerebral artery thrombosis 70.03 11.28 32 91315 1636 110496316
Device alarm issue 69.72 11.28 36 91311 2410 110495542
Device related infection 68.91 11.28 120 91227 39399 110458553
Off label use 68.45 11.28 853 90494 1499332 108998620
Confusional state 68.00 11.28 182 91165 468498 110029454
Cardiac arrest 67.12 11.28 331 91016 196422 110301530
Intentional overdose 66.71 11.28 14 91333 132487 110365465
Subcutaneous emphysema 65.04 11.28 35 91312 2549 110495403
Oxygen saturation abnormal 64.22 11.28 46 91301 5565 110492387
Palpitations 63.99 11.28 281 91066 158931 110339021
Lip dry 63.68 11.28 5 91342 100078 110397874
Infusion site infection 63.49 11.28 33 91314 2239 110495713
Therapeutic product effect incomplete 63.28 11.28 55 91292 223750 110274202
Emphysema 61.94 11.28 79 91268 19677 110478275
Air embolism 60.56 11.28 22 91325 618 110497334
Pulmonary hypertensive crisis 59.78 11.28 20 91327 437 110497515
Heart rate increased 59.44 11.28 256 91091 143578 110354374
Arthralgia 59.25 11.28 389 90958 779243 109718709
Transplant evaluation 58.11 11.28 29 91318 1806 110496146
Exercise tolerance decreased 57.68 11.28 60 91287 12007 110485945
Psoriasis 57.18 11.28 22 91325 139971 110357981
Cardiac failure acute 56.93 11.28 84 91263 23994 110473958
Dizziness 56.44 11.28 849 90498 697344 109800608
Inflammation 55.22 11.28 47 91300 193191 110304761
Catheter placement 54.34 11.28 34 91313 3286 110494666
Ill-defined disorder 54.28 11.28 31 91316 156822 110341130
Catheter site rash 53.47 11.28 23 91324 1017 110496935
Catheter site haemorrhage 53.47 11.28 42 91305 5838 110492114
Pulmonary congestion 52.65 11.28 93 91254 30873 110467079
Injury 52.03 11.28 42 91305 177223 110320729
Osteoarthritis 51.48 11.28 45 91302 182578 110315374
Hypercholesterolaemia 51.45 11.28 7 91340 90830 110407122
Dyspnoea at rest 50.12 11.28 47 91300 8299 110489653
Lower respiratory tract infection 50.08 11.28 77 91270 243029 110254923
C-reactive protein increased 49.89 11.28 64 91283 217855 110280097
Cor pulmonale 49.30 11.28 28 91319 2266 110495686
Peripheral venous disease 48.81 11.28 6 91341 84111 110413841
Pulmonary function test decreased 48.46 11.28 47 91300 8653 110489299
Pruritus 47.85 11.28 283 91064 581277 109916675
Orthopnoea 47.73 11.28 52 91295 10969 110486983
Colitis ulcerative 46.18 11.28 5 91342 77358 110420594
Obesity 45.98 11.28 18 91329 113333 110384619
Grip strength decreased 45.84 11.28 6 91341 80168 110417784
Pulseless electrical activity 44.82 11.28 62 91285 16695 110481257
Atrial fibrillation 44.77 11.28 334 91013 229308 110268644
Red blood cell sedimentation rate increased 44.43 11.28 6 91341 78296 110419656
Interstitial lung disease 44.41 11.28 230 91117 139104 110358848
Respiratory tract infection 44.20 11.28 145 91202 71472 110426480
Nasal dryness 43.96 11.28 37 91310 5669 110492283
Pneumomediastinum 43.71 11.28 35 91312 5001 110492951
Wound infection 43.14 11.28 13 91334 96452 110401500
Night sweats 42.87 11.28 29 91318 133954 110363998
Suicide attempt 42.63 11.28 16 91331 103378 110394574
Hospitalisation 42.53 11.28 231 91116 142262 110355690
Rhinocerebral mucormycosis 42.30 11.28 22 91325 1495 110496457
Pulmonary arterial pressure abnormal 42.28 11.28 19 91328 934 110497018
Ventilation perfusion mismatch 42.21 11.28 18 91329 779 110497173
Hypertension 41.53 11.28 249 91098 509835 109988117
Carbon dioxide increased 41.28 11.28 27 91320 2817 110495135
Bronchitis 41.23 11.28 246 91101 156786 110341166
Pulmonary haemorrhage 41.22 11.28 59 91288 16397 110481555
Infusion site erythema 40.97 11.28 50 91297 11909 110486043
Product dose omission issue 40.89 11.28 426 90921 321356 110176596
Feeling abnormal 40.57 11.28 272 91075 180439 110317513
Neuromuscular block prolonged 40.36 11.28 20 91327 1227 110496725
Device occlusion 40.34 11.28 56 91291 15129 110482823
Walking distance test abnormal 40.01 11.28 17 91330 729 110497223
Injection site reaction 39.83 11.28 12 91335 89058 110408894
Left ventricular failure 39.64 11.28 48 91299 11341 110486611
Cardiomegaly 39.00 11.28 79 91268 29051 110468901
Cardiac disorder 38.90 11.28 145 91202 76135 110421817
Hepatitis 38.73 11.28 13 91334 90041 110407911
Tachypnoea 38.28 11.28 94 91253 39301 110458651
Sleep disorder 38.03 11.28 66 91281 198578 110299374
Live birth 37.86 11.28 6 91341 69478 110428474
N-terminal prohormone brain natriuretic peptide increased 37.78 11.28 35 91312 6086 110491866
Anaesthetic complication 37.72 11.28 28 91319 3578 110494374
Depression 37.63 11.28 135 91212 317200 110180752
Secretion discharge 37.30 11.28 63 91284 20181 110477771
Pain 37.25 11.28 560 90787 954395 109543557
Device connection issue 37.03 11.28 19 91328 1255 110496697
Febrile neutropenia 36.75 11.28 136 91211 316631 110181321
Presyncope 36.70 11.28 106 91241 48781 110449171
Areflexia 36.64 11.28 36 91311 6733 110491219
Atrial flutter 36.36 11.28 69 91278 24193 110473759
Mucosal inflammation 36.23 11.28 17 91330 96124 110401828
Complication associated with device 33.76 11.28 60 91287 20013 110477939
Pneumonia bacterial 33.71 11.28 70 91277 26191 110471761
Neuromuscular blockade 33.54 11.28 15 91332 729 110497223
Seasonal allergy 33.23 11.28 59 91288 19663 110478289
Paraesthesia 33.21 11.28 117 91230 276404 110221548
Toxic epidermal necrolysis 33.02 11.28 4 91343 56723 110441229
Nocturnal dyspnoea 32.72 11.28 20 91327 1855 110496097
Device infusion issue 32.66 11.28 24 91323 3021 110494931
Catheter site scab 32.55 11.28 11 91336 248 110497704
Product use in unapproved indication 32.52 11.28 226 91121 447151 110050801
Supraventricular tachycardia 32.42 11.28 66 91281 24356 110473596
Catheter removal 32.15 11.28 14 91333 638 110497314
Coma 32.07 11.28 30 91317 117839 110380113
Respiratory syncytial virus infection 32.06 11.28 49 91298 14435 110483517
Pulmonary artery dilatation 31.99 11.28 14 91333 646 110497306
Condition aggravated 31.51 11.28 812 90535 734024 109763928
Cardiac pacemaker insertion 31.33 11.28 32 91315 6269 110491683
Catheter site swelling 31.16 11.28 21 91326 2303 110495649
Concomitant disease progression 31.14 11.28 25 91322 3585 110494367
Pulmonary alveolar haemorrhage 31.06 11.28 58 91289 20092 110477860
Loss of consciousness 30.92 11.28 272 91075 196034 110301918
Right ventricular dysfunction 30.79 11.28 24 91323 3299 110494653
Suicidal ideation 30.50 11.28 20 91327 93917 110404035
Knee arthroplasty 30.44 11.28 8 91339 64940 110433012
Acute right ventricular failure 30.20 11.28 12 91335 433 110497519
Apnoea 29.99 11.28 46 91301 13593 110484359
Paracentesis 29.85 11.28 17 91330 1383 110496569
Maternal exposure during pregnancy 29.84 11.28 109 91238 254774 110243178
Central venous catheterisation 29.78 11.28 25 91322 3817 110494135
Delayed recovery from anaesthesia 29.66 11.28 20 91327 2195 110495757
Sputum discoloured 29.65 11.28 69 91278 27876 110470076
Hypoaesthesia 29.62 11.28 146 91201 314077 110183875
Sciatica 29.56 11.28 20 91327 92379 110405573
Respiratory acidosis 29.52 11.28 46 91301 13780 110484172
Prescribed overdose 29.32 11.28 18 91329 87563 110410389
Bronchospasm 29.22 11.28 72 91275 30167 110467785
Gamma-glutamyltransferase increased 29.17 11.28 114 91233 61195 110436757
Bradycardia 29.06 11.28 224 91123 155293 110342659
Malaise 28.98 11.28 743 90604 671076 109826876
Aspiration pleural cavity 28.97 11.28 18 91329 1719 110496233
Congestive hepatopathy 28.70 11.28 28 91319 5192 110492760
Cardiac ablation 28.45 11.28 21 91326 2661 110495291
Pulmonary capillary haemangiomatosis 28.43 11.28 8 91339 95 110497857
COVID-19 pneumonia 28.33 11.28 81 91266 37062 110460890
Abdominal pain 28.26 11.28 279 91068 512710 109985242
Agranulocytosis 28.20 11.28 8 91339 61752 110436200
Injection site erythema 28.02 11.28 22 91325 94154 110403798
Pulmonary function test abnormal 27.83 11.28 27 91320 4973 110492979
Rales 27.26 11.28 62 91285 24677 110473275
Abdominal distension 27.25 11.28 242 91105 174861 110323091
Autoimmune disorder 27.22 11.28 10 91337 65473 110432479
Onychomadesis 27.13 11.28 3 91344 45660 110452292
Epilepsy 26.68 11.28 26 91321 100183 110397769
Neoplasm progression 26.62 11.28 10 91337 64585 110433367
Rhonchi 26.28 11.28 25 91322 4493 110493459
Catheter site warmth 26.21 11.28 10 91337 323 110497629
Gastrointestinal disorder 26.05 11.28 107 91240 241845 110256107
Tracheostomy 25.91 11.28 16 91331 1511 110496441
Malignant neoplasm progression 25.87 11.28 67 91280 174500 110323452
Exposure during pregnancy 25.79 11.28 63 91284 167361 110330591
Mediastinal effusion 25.54 11.28 7 91340 75 110497877
Gait inability 25.47 11.28 46 91301 136330 110361622
Prescribed underdose 25.38 11.28 11 91336 65163 110432789
Blood alkaline phosphatase increased 25.36 11.28 121 91226 70814 110427138
Anaemia 25.34 11.28 611 90736 546475 109951477
Coeliac disease 25.25 11.28 3 91344 43184 110454768
Neutrophil count decreased 25.19 11.28 38 91309 120903 110377049
Rhinorrhoea 25.15 11.28 158 91189 102508 110395444
Aspartate aminotransferase increased 24.87 11.28 221 91126 159715 110338237
Tubulointerstitial nephritis 24.85 11.28 7 91340 54277 110443675
Haemodynamic instability 24.82 11.28 57 91290 22831 110475121
Oxygen consumption 24.81 11.28 7 91340 84 110497868
Haemoglobin decreased 24.71 11.28 314 91033 248413 110249539
Bronchopulmonary aspergillosis 24.63 11.28 67 91280 29796 110468156
Myelosuppression 24.52 11.28 25 91322 94315 110403637
Leukopenia 24.52 11.28 54 91293 148737 110349215
Oedematous kidney 24.50 11.28 9 91338 261 110497691
Device leakage 24.50 11.28 46 91301 16002 110481950
Cognitive disorder 24.13 11.28 22 91325 87489 110410463
Lung adenocarcinoma stage IV 24.12 11.28 11 91336 560 110497392
Infusion site haemorrhage 24.05 11.28 24 91323 4574 110493378
Catheter site inflammation 23.64 11.28 14 91333 1226 110496726
General physical health deterioration 23.54 11.28 231 91116 425064 110072888
Stevens-Johnson syndrome 23.51 11.28 5 91342 46896 110451056
Disseminated strongyloidiasis 23.44 11.28 11 91336 598 110497354
Lung infiltration 23.12 11.28 58 91289 24570 110473382
Ventricular tachycardia 22.99 11.28 92 91255 49917 110448035
Hyponatraemia 22.97 11.28 97 91250 217556 110280396
Sepsis 22.95 11.28 389 90958 326957 110170995
Musculoskeletal pain 22.94 11.28 76 91271 182947 110315005
Drug resistance 22.78 11.28 9 91338 56365 110441587
Foot deformity 22.66 11.28 6 91341 48474 110449478
Rash maculo-papular 22.51 11.28 17 91330 74205 110423747
Osteonecrosis of jaw 22.34 11.28 6 91341 48011 110449941
Procedural complication 22.33 11.28 31 91316 8374 110489578
Angioplasty 22.19 11.28 16 91331 1955 110495997
Adverse drug reaction 22.15 11.28 33 91314 105526 110392426
Multiple sclerosis relapse 22.05 11.28 7 91340 50233 110447719
Hepatic cytolysis 21.90 11.28 9 91338 55044 110442908
Swelling 21.88 11.28 185 91162 350856 110147096
Onychomycosis 21.75 11.28 3 91344 38528 110459424
Pulmonary trichosporonosis 21.74 11.28 6 91341 66 110497886
Hyperthermia malignant 21.59 11.28 21 91326 3879 110494073
Localised oedema 21.55 11.28 32 91315 9191 110488761
Aggression 21.50 11.28 11 91336 59199 110438753
Taste disorder 21.12 11.28 14 91333 65373 110432579
Platelet transfusion 20.99 11.28 18 91329 2828 110495124
Intentional self-injury 20.92 11.28 3 91344 37426 110460526
Acute postoperative sialadenitis 20.90 11.28 6 91341 77 110497875
Increased ventricular preload 20.65 11.28 5 91342 31 110497921
Mouth ulceration 20.61 11.28 7 91340 48131 110449821
Mechanical ventilation 20.59 11.28 19 91328 3288 110494664
Weight decreased 20.54 11.28 519 90828 467538 110030414
Colitis 20.50 11.28 33 91314 102290 110395662
Accidental underdose 20.45 11.28 13 91334 1292 110496660
Cold burn 20.36 11.28 4 91343 7 110497945
Right ventricular systolic pressure increased 20.20 11.28 12 91335 1057 110496895
Medication error 20.17 11.28 35 91312 105331 110392621
Decreased activity 20.02 11.28 34 91313 10940 110487012
Dizziness postural 20.01 11.28 40 91307 14569 110483383
Dry mouth 19.95 11.28 91 91256 199857 110298095
Infusion site discharge 19.93 11.28 15 91332 1958 110495994
Blood potassium decreased 19.85 11.28 93 91254 54021 110443931
Catheter site granuloma 19.68 11.28 6 91341 96 110497856
Upper respiratory tract inflammation 19.59 11.28 21 91326 4350 110493602
Iron deficiency anaemia 19.56 11.28 64 91283 31495 110466457
Right-to-left cardiac shunt 19.43 11.28 8 91339 317 110497635
Pulmonary artery banding 19.40 11.28 4 91343 10 110497942
Road traffic accident 19.37 11.28 37 91310 107361 110390591
PaO2/FiO2 ratio decreased 19.33 11.28 5 91342 42 110497910
Choking sensation 19.33 11.28 21 91326 4415 110493537
Anaesthetic complication cardiac 19.29 11.28 6 91341 103 110497849
Pregnancy 19.29 11.28 9 91338 51058 110446894
Abdominal cavity drainage 19.26 11.28 11 91336 900 110497052
Hypoglycaemia 19.24 11.28 42 91305 116062 110381890
White blood cell count decreased 19.16 11.28 111 91236 229279 110268673
Injection site swelling 18.94 11.28 14 91333 61776 110436176
Haematocrit decreased 18.92 11.28 106 91241 66011 110431941
Vascular device infection 18.88 11.28 42 91305 16470 110481482
Urine output decreased 18.86 11.28 47 91300 19829 110478123
Retching 18.81 11.28 51 91296 22631 110475321
Thrombocytopenia 18.67 11.28 191 91156 348694 110149258
Product use issue 18.65 11.28 166 91181 311529 110186423
Ascites 18.65 11.28 136 91211 92672 110405280
Blood immunoglobulin E 18.64 11.28 5 91342 49 110497903
Angioedema 18.60 11.28 33 91314 98467 110399485
Liver disorder 18.57 11.28 58 91289 142185 110355767
Cytomegalovirus infection 18.49 11.28 11 91336 54433 110443519
Injection site pain 18.34 11.28 80 91267 177842 110320110
Inappropriate antidiuretic hormone secretion 18.27 11.28 3 91344 33848 110464104
Throat irritation 18.17 11.28 90 91257 53462 110444490
Tricuspid valve incompetence 18.15 11.28 52 91295 23821 110474131
Arthritis 18.11 11.28 74 91273 167512 110330440
Cardiorenal syndrome 18.09 11.28 14 91333 1904 110496048
Pancreatitis 17.96 11.28 31 91316 93502 110404450
Jugular vein distension 17.93 11.28 13 91334 1603 110496349
Bone marrow failure 17.87 11.28 13 91334 57835 110440117
Nightmare 17.81 11.28 5 91342 38858 110459094
Middle ear effusion 17.75 11.28 16 91331 2685 110495267
Finger deformity 17.71 11.28 3 91344 33089 110464863
Dermatitis contact 17.69 11.28 37 91310 13916 110484036
Exercise test abnormal 17.65 11.28 5 91342 61 110497891
Alkalosis hypochloraemic 17.58 11.28 9 91338 592 110497360
Osteoporosis 17.56 11.28 28 91319 87124 110410828
Overdose 17.52 11.28 117 91230 233677 110264275
Catheter site vesicles 17.43 11.28 8 91339 413 110497539
Illness 17.43 11.28 122 91225 82049 110415903
Right ventricular dilatation 17.41 11.28 15 91332 2372 110495580
Uterine hypotonus 17.37 11.28 6 91341 145 110497807
SARS-CoV-2 viraemia 17.29 11.28 6 91341 147 110497805
Tachycardia 17.24 11.28 273 91074 226372 110271580
Chills 17.01 11.28 236 91111 190344 110307608
Glossoptosis 16.98 11.28 7 91340 278 110497674
Lung assist device therapy 16.95 11.28 6 91341 156 110497796
Catheter site irritation 16.91 11.28 9 91338 641 110497311
Hospice care 16.90 11.28 34 91313 12439 110485513
Swollen tongue 16.85 11.28 15 91332 60347 110437605
Emergency care 16.83 11.28 12 91335 1441 110496511
Procedural hypotension 16.78 11.28 15 91332 2490 110495462
Argon plasma coagulation 16.78 11.28 4 91343 23 110497929
Amnesia 16.76 11.28 39 91308 105369 110392583
Terminal state 16.73 11.28 22 91325 5645 110492307
Infusion site irritation 16.68 11.28 11 91336 1164 110496788
Eosinophilia 16.65 11.28 14 91333 57922 110440030
Hip arthroplasty 16.65 11.28 13 91334 55800 110442152
Rehabilitation therapy 16.62 11.28 14 91333 2147 110495805
Malassezia infection 16.58 11.28 5 91342 77 110497875
Rotavirus infection 16.46 11.28 10 91337 917 110497035
Sedation 16.43 11.28 20 91327 69663 110428289
Muscular weakness 16.37 11.28 129 91218 248339 110249613
Psychotic disorder 16.32 11.28 11 91336 50926 110447026
Burns third degree 16.23 11.28 8 91339 485 110497467
Cardiac failure high output 15.97 11.28 8 91339 502 110497450
Brain hypoxia 15.81 11.28 11 91336 1271 110496681
Barotrauma 15.78 11.28 6 91341 192 110497760
Myotonic dystrophy 15.75 11.28 6 91341 193 110497759
Cardioversion 15.74 11.28 14 91333 2309 110495643
Blood iron decreased 15.73 11.28 43 91304 19171 110478781
Atelectasis 15.66 11.28 66 91281 36646 110461306
Mucormycosis 15.65 11.28 30 91317 10598 110487354
Drug-induced liver injury 15.64 11.28 49 91298 120018 110377934
Pancreatitis haemorrhagic 15.62 11.28 10 91337 1006 110496946
Right ventricular enlargement 15.57 11.28 10 91337 1011 110496941
Pulmonary thrombosis 15.56 11.28 35 91312 13828 110484124
Corynebacterium bacteraemia 15.55 11.28 6 91341 200 110497752
Diarrhoea 15.47 11.28 1116 90231 1138389 109359563
Thyroglobulin increased 15.41 11.28 5 91342 99 110497853
Therapy non-responder 15.36 11.28 198 91149 157109 110340843
Stent placement 15.35 11.28 24 91323 7210 110490742
Catheter site hypersensitivity 15.27 11.28 5 91342 102 110497850
Bifidobacterium infection 15.18 11.28 5 91342 104 110497848
Catheter site dermatitis 15.13 11.28 5 91342 105 110497847
Head injury 15.10 11.28 73 91274 42944 110455008
Right ventricular hypertrophy 15.03 11.28 12 91335 1707 110496245
Ventricular extrasystoles 15.02 11.28 47 91300 22594 110475358
Disease progression 14.97 11.28 284 91063 243750 110254202
Haemoglobin increased 14.94 11.28 27 91320 9120 110488832
Multiple allergies 14.94 11.28 32 91315 12231 110485721
Neuropathy peripheral 14.83 11.28 87 91260 179190 110318762
Infusion site abscess 14.82 11.28 7 91340 386 110497566
Poisoning 14.80 11.28 3 91344 29102 110468850
Limb injury 14.78 11.28 66 91281 37570 110460382
Cholestasis 14.70 11.28 19 91328 64499 110433453
Liver function test increased 14.70 11.28 32 91315 88516 110409436
Rhinovirus infection 14.64 11.28 31 91316 11758 110486194
Stress cardiomyopathy 14.60 11.28 37 91310 15769 110482183
Joint dislocation 14.59 11.28 5 91342 34185 110463767
Craniotomy 14.57 11.28 8 91339 606 110497346
Lower limb fracture 14.44 11.28 25 91322 75323 110422629
Acute respiratory distress syndrome 14.38 11.28 84 91263 53114 110444838
Pulmonary nocardiosis 14.26 11.28 14 91333 2615 110495337
Hallucination 14.22 11.28 40 91307 101392 110396560
Acute kidney injury 14.18 11.28 408 90939 635022 109862930
Airway burns 14.15 11.28 3 91344 9 110497943
Cardiac assistance device user 14.09 11.28 5 91342 131 110497821
Injection site pruritus 13.99 11.28 13 91334 51245 110446707
Gastrointestinal haemorrhage 13.99 11.28 203 91144 165315 110332637
Chapped lips 13.97 11.28 15 91332 3113 110494839
Cerebral haemorrhage 13.93 11.28 20 91327 64948 110433004
Hypophosphataemia 13.90 11.28 5 91342 33177 110464775
Respiratory rate increased 13.90 11.28 49 91298 25034 110472918
Accident 13.83 11.28 29 91318 10923 110487029
Bronchopulmonary dysplasia 13.77 11.28 6 91341 274 110497678
Electrocardiogram ST segment elevation 13.66 11.28 26 91321 9134 110488818
Gastrointestinal arteriovenous malformation 13.61 11.28 9 91338 956 110496996
Systemic scleroderma 13.59 11.28 12 91335 1960 110495992
Intentional product misuse 13.55 11.28 60 91287 132844 110365108
Peripheral swelling 13.54 11.28 433 90914 403601 110094351
Device dislocation 13.53 11.28 57 91290 31647 110466305
Paradoxical embolism 13.48 11.28 4 91343 58 110497894
Infusion site swelling 13.47 11.28 27 91320 9850 110488102
Vena cava filter insertion 13.45 11.28 5 91342 150 110497802
Chronic left ventricular failure 13.42 11.28 10 91337 1286 110496666
Haemorrhage 13.41 11.28 141 91206 106551 110391401
Therapy partial responder 13.29 11.28 7 91340 37054 110460898
Dialysis 13.27 11.28 41 91306 19578 110478374
Pulmonary vein stenosis 13.21 11.28 5 91342 158 110497794
Sinus congestion 13.18 11.28 55 91292 30404 110467548
Right atrial dilatation 13.16 11.28 9 91338 1011 110496941
Mastitis bacterial 13.12 11.28 4 91343 64 110497888
Rhabdomyolysis 13.11 11.28 53 91294 120348 110377604
Alanine aminotransferase increased 13.09 11.28 219 91128 183554 110314398
Gastrointestinal tube insertion 12.94 11.28 12 91335 2089 110495863
Jaundice 12.93 11.28 18 91329 59218 110438734
Agonal respiration 12.93 11.28 6 91341 318 110497634
Oxygen saturation increased 12.91 11.28 8 91339 760 110497192
Acute pulmonary oedema 12.90 11.28 37 91310 16959 110480993
Puncture site infection 12.89 11.28 4 91343 68 110497884
Respiratory disorder 12.88 11.28 102 91245 71280 110426672
Pulmonary toxicity 12.86 11.28 38 91309 17708 110480244
Dysbiosis 12.79 11.28 12 91335 2120 110495832
Catheter site erosion 12.79 11.28 4 91343 70 110497882
Right ventricular systolic pressure 12.62 11.28 3 91344 17 110497935
Pseudomonas infection 12.61 11.28 51 91296 27802 110470150
Muscle spasticity 12.56 11.28 7 91340 35908 110462044
Choking 12.56 11.28 34 91313 15076 110482876
Device malfunction 12.54 11.28 48 91299 25510 110472442
Myositis 12.52 11.28 5 91342 31111 110466841
Incorrect route of product administration 12.51 11.28 21 91326 64040 110433912
Blood urea increased 12.49 11.28 83 91264 54874 110443078
Thoracic cavity drainage 12.44 11.28 6 91341 347 110497605
Abdominal discomfort 12.36 11.28 240 91107 393618 110104334
Proteinuria 12.35 11.28 9 91338 40009 110457943
Blood carbon monoxide increased 12.34 11.28 3 91344 19 110497933
Rectal haemorrhage 12.27 11.28 54 91293 119779 110378173
Influenza 12.22 11.28 202 91145 168899 110329053
Sinusitis 12.20 11.28 172 91175 296516 110201436
PO2 decreased 12.17 11.28 14 91333 3134 110494818
Pulmonary pain 12.15 11.28 20 91327 6273 110491679
Sputum increased 12.09 11.28 19 91328 5732 110492220
Cerebral infarction 12.09 11.28 15 91332 51823 110446129
Lung squamous cell carcinoma stage I 12.08 11.28 3 91344 21 110497931
Cardiac septal defect repair 12.08 11.28 3 91344 21 110497931
Therapy interrupted 12.06 11.28 14 91333 49808 110448144
Mineral supplementation 12.04 11.28 8 91339 857 110497095
Vascular cauterisation 11.93 11.28 4 91343 88 110497864
Breath sounds abnormal 11.89 11.28 47 91300 25357 110472595
Progressive multifocal leukoencephalopathy 11.83 11.28 3 91344 24953 110472999
Back injury 11.82 11.28 13 91334 47386 110450566
Bronchopleural fistula 11.81 11.28 8 91339 885 110497067
Drug tolerance decreased 11.80 11.28 4 91343 27536 110470416
Impaired quality of life 11.79 11.28 5 91342 30012 110467940
Nasal operation 11.78 11.28 6 91341 390 110497562
Haematoma evacuation 11.78 11.28 6 91341 390 110497562
Vasodilatation 11.78 11.28 15 91332 3729 110494223
Superinfection fungal 11.72 11.28 4 91343 93 110497859
Device issue 11.69 11.28 58 91289 34477 110463475
Oxygen saturation 11.68 11.28 6 91341 397 110497555
Infusion site vesicles 11.66 11.28 7 91340 628 110497324
PCO2 increased 11.62 11.28 11 91336 1966 110495986
Infection 11.58 11.28 220 91127 361980 110135972
Emotional distress 11.52 11.28 12 91335 44835 110453117
Cervix enlargement 11.52 11.28 3 91344 26 110497926
Disturbance in attention 11.49 11.28 21 91326 61974 110435978
Post procedural complication 11.43 11.28 48 91299 26610 110471342
Tracheal injury 11.40 11.28 5 91342 232 110497720
Heart rate abnormal 11.36 11.28 21 91326 7217 110490735
Hyperhomocysteinaemia 11.35 11.28 7 91340 660 110497292
Blood bilirubin increased 11.30 11.28 104 91243 75868 110422084
Laryngitis 11.29 11.28 11 91336 42400 110455552
Oral herpes 11.28 11.28 8 91339 36072 110461880

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AN04 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:33937 macronutrients

Related Drugs by ATC class:

V03AN Medical gases 3 drugs
carbon dioxideheliumoxygen

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Persistent pulmonary hypertension of the newborn indication 233815004 DOID:13042
Methemoglobinemia contraindication 38959009 DOID:10783
Left heart failure contraindication 85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
None (Med Gas) Air Liquide Industrial U.S. L.P. 2
None (Med Gas) Air Liquide Large Industries U.S. L.P. 2
None (Med Gas) Messer LLC 2
None (Med Gas) Norco Inc. 2
None (Med Gas) Messer Gas Puerto Rico Inc. 2
None (Med Gas) Air Liquide America L.P. 2
None (Med Gas) Airgas Merchant Gases LLC 2
None (Med Gas) Praxair Inc. 2
None (Med Gas) Aspen Air, US Corp 2
None (Med Gas) Air Products and Chemicals Inc. 2
None (Med Gas) Matheson Tri-Gas Inc. 2
None (Med Gas) Praxair Canada Inc. 2
None (Med Gas) Airgas USA LLC 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019163 VUID
N0000147408 NUI
D00083 KEGG_DRUG
4019163 VANDF
C0028158 UMLSCUI
CHEBI:17997 CHEBI
NGN PDB_CHEM_ID
CHEMBL142438 ChEMBL_ID
D009584 MESH_DESCRIPTOR_UI
DB09152 DRUGBANK_ID
N762921K75 UNII
947 PUBCHEM_CID
7456 RXNORM
002515 NDDF
36012007 SNOMEDCT_US
767123001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10018-9502 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-003 LIQUID 990 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-020 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-021 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-022 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-023 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10678-002 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10690-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10690-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10698-0002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
COMPRESSED GAS N.O.S. HUMAN PRESCRIPTION DRUG LABEL 3 10736-011 GAS 75.05 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10736-203 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10825-003 GAS 90 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10913-010 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-101 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-106 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2000 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2010 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2010 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections