oxygen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4235 7782-44-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxygen
  • molecular oxygen
  • oxygen molecule
  • oxygen, usp
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
  • Molecular weight: 32.00
  • Formula: O2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1181.37 11.88 2326 69879 878629 89677613
Pulmonary arterial hypertension 871.95 11.88 423 71782 25764 90530478
Oxygen saturation decreased 775.76 11.88 660 71545 106823 90449419
Pulmonary hypertension 682.36 11.88 424 71781 42099 90514143
Oxygen consumption increased 533.06 11.88 182 72023 4407 90551835
Right ventricular failure 517.92 11.88 269 71936 18936 90537306
Dyspnoea exertional 491.01 11.88 429 71776 71859 90484383
Respiratory failure 420.97 11.88 495 71710 117923 90438319
Hypoxia 415.74 11.88 391 71814 72008 90484234
Fluid retention 388.20 11.88 412 71793 87679 90468563
Chronic obstructive pulmonary disease 379.18 11.88 375 71830 73454 90482788
Hypervolaemia 330.08 11.88 245 71960 32512 90523730
Drug ineffective 307.89 11.88 393 71812 1383905 89172337
Cough 254.52 11.88 757 71448 368205 90188037
Pain in jaw 244.93 11.88 243 71962 47742 90508500
Pneumonia 239.16 11.88 1073 71132 636986 89919256
Acute respiratory failure 235.25 11.88 226 71979 42692 90513550
Glossodynia 228.27 11.88 6 72199 321773 90234469
Oxygen therapy 225.34 11.88 87 72118 3015 90553227
Arthropathy 224.17 11.88 18 72187 366224 90190018
Contraindicated product administered 209.89 11.88 11 72194 320128 90236114
Transfusion 208.71 11.88 145 72060 17343 90538899
Hand deformity 204.85 11.88 7 72198 296355 90259887
Cardiac failure 196.70 11.88 330 71875 109166 90447076
Systemic lupus erythematosus 195.51 11.88 28 72177 361868 90194374
Epistaxis 195.19 11.88 287 71918 84838 90471404
Productive cough 193.07 11.88 271 71934 76792 90479450
Alopecia 192.34 11.88 77 72128 494994 90061248
Treatment failure 188.60 11.88 14 72191 303914 90252328
Nasal congestion 183.74 11.88 276 71929 83138 90473104
Death 176.91 11.88 776 71429 455775 90100467
Pulmonary oedema 174.72 11.88 231 71974 61849 90494393
Therapeutic product effect decreased 166.08 11.88 15 72190 277556 90278686
Helicobacter infection 165.66 11.88 3 72202 226847 90329395
Rheumatoid arthritis 160.64 11.88 45 72160 362569 90193673
Pericarditis 160.56 11.88 15 72190 270136 90286106
Hepatic enzyme increased 159.37 11.88 45 72160 360691 90195551
Psoriatic arthropathy 159.16 11.88 5 72200 228330 90327912
Oedema peripheral 157.92 11.88 508 71697 257407 90298835
Joint swelling 155.90 11.88 105 72100 503195 90053047
Hypotension 153.54 11.88 588 71617 324809 90231433
Rash 149.75 11.88 253 71952 795847 89760395
Wound 147.07 11.88 31 72174 302949 90253293
Drug intolerance 141.81 11.88 91 72114 447500 90108742
Infusion related reaction 141.51 11.88 78 72127 416702 90139540
Pulmonary arterial pressure increased 138.57 11.88 66 72139 3850 90552392
Syncope 137.18 11.88 317 71888 132346 90423896
Haemoglobin increased 136.36 11.88 81 72124 7400 90548842
Catheter site erythema 127.47 11.88 67 72138 4827 90551415
Haemoptysis 126.13 11.88 144 72061 33176 90523066
Stomatitis 125.57 11.88 32 72173 274666 90281576
Blood pressure decreased 124.30 11.88 218 71987 74677 90481565
Impaired healing 122.12 11.88 20 72185 234179 90322063
Irritable bowel syndrome 121.97 11.88 12 72193 207436 90348806
Discomfort 119.69 11.88 35 72170 274300 90281942
Drug hypersensitivity 119.46 11.88 116 72089 463493 90092749
Cardiac failure congestive 119.17 11.88 251 71954 98443 90457799
Musculoskeletal stiffness 116.89 11.88 45 72160 296487 90259755
Blood cholesterol increased 114.85 11.88 15 72190 207997 90348245
Blister 114.09 11.88 31 72174 254967 90301275
Catheter site pruritus 110.55 11.88 48 72157 2254 90553988
Hypercapnia 108.08 11.88 67 72138 6610 90549632
Concomitant disease aggravated 106.80 11.88 82 72123 11436 90544806
Hypersensitivity 105.71 11.88 124 72081 454553 90101689
Liver injury 105.35 11.88 8 72197 170559 90385683
Chest pain 104.23 11.88 517 71688 319128 90237114
Infusion site pain 102.62 11.88 101 72104 19637 90536605
Lung transplant 100.32 11.88 52 72153 3640 90552602
Chest discomfort 100.00 11.88 289 71916 138076 90418166
Pericardial effusion 97.41 11.88 133 72072 36700 90519542
Headache 96.90 11.88 1081 71124 861665 89694577
Type 2 diabetes mellitus 96.15 11.88 22 72183 203222 90353020
Mobility decreased 94.01 11.88 41 72164 250693 90305549
Fibromyalgia 92.40 11.88 25 72180 206244 90349998
Palpitations 91.59 11.88 278 71927 136450 90419792
Scleroderma 89.30 11.88 58 72147 6203 90550039
Pleural effusion 88.85 11.88 242 71963 111749 90444493
Flushing 87.67 11.88 208 71997 88283 90467959
Dependence on oxygen therapy 86.82 11.88 28 72177 564 90555678
Toxicity to various agents 86.43 11.88 62 72143 287784 90268458
Infusion site infection 85.57 11.88 42 72163 2618 90553624
Off label use 85.01 11.88 523 71682 1101729 89454513
Injury 84.56 11.88 26 72179 197323 90358919
Brain natriuretic peptide increased 84.11 11.88 55 72150 5950 90550292
Catheter management 83.18 11.88 43 72162 2993 90553249
Bursitis 81.79 11.88 6 72199 131648 90424594
Urticaria 80.78 11.88 78 72127 312656 90243586
Intentional product use issue 80.46 11.88 36 72169 216856 90339386
Respiratory distress 80.27 11.88 125 72080 38821 90517421
Joint range of motion decreased 79.31 11.88 8 72197 135635 90420607
Ill-defined disorder 78.07 11.88 25 72180 184866 90371376
Arthralgia 74.01 11.88 344 71861 778178 89778064
Pulmonary veno-occlusive disease 73.63 11.88 32 72173 1506 90554736
Device alarm issue 73.58 11.88 34 72171 1851 90554391
Catheterisation cardiac 70.91 11.88 46 72159 4910 90551332
Cyanosis 70.13 11.88 82 72123 19373 90536869
Dizziness 68.09 11.88 743 71462 588541 89967701
Exercise tolerance decreased 66.19 11.88 52 72153 7499 90548743
Product use issue 65.43 11.88 101 72104 329818 90226424
Lower respiratory tract infection 65.31 11.88 62 72143 250597 90305645
Device related infection 65.01 11.88 91 72114 25695 90530547
Cor pulmonale 64.70 11.88 32 72173 2028 90554214
Lip dry 64.47 11.88 4 72201 100951 90455291
Psoriasis 64.13 11.88 19 72186 147735 90408507
Maternal exposure during pregnancy 63.36 11.88 119 72086 359944 90196298
Osteoarthritis 62.99 11.88 39 72166 195691 90360551
Chronic respiratory failure 61.53 11.88 34 72171 2707 90553535
Catheter site pain 61.32 11.88 44 72161 5535 90550707
Catheter site discharge 59.97 11.88 32 72173 2377 90553865
Presyncope 59.93 11.88 98 72107 31707 90524535
Heart rate increased 59.81 11.88 212 71993 112690 90443552
Oxygen saturation abnormal 59.39 11.88 39 72166 4249 90551993
Therapeutic product effect incomplete 59.18 11.88 41 72164 193855 90362387
Hypercholesterolaemia 58.85 11.88 6 72199 100886 90455356
Unevaluable event 58.79 11.88 133 72072 54715 90501527
Catheter site infection 58.53 11.88 43 72162 5611 90550631
Inflammation 58.28 11.88 35 72170 178557 90377685
Grip strength decreased 58.13 11.88 4 72201 92572 90463670
Anaemia 57.69 11.88 479 71726 352323 90203919
C-reactive protein increased 57.18 11.88 37 72168 181352 90374890
Cardiac disorder 56.66 11.88 134 72071 56738 90499504
Cardiac arrest 56.41 11.88 198 72007 104737 90451505
Pruritus 55.79 11.88 232 71973 541293 90014949
Cardiac failure acute 54.63 11.88 57 72148 11872 90544370
Swelling 54.20 11.88 163 72042 418895 90137347
Thermal burn 53.80 11.88 44 72161 6718 90549524
Orthopnoea 53.39 11.88 44 72161 6791 90549451
Air embolism 52.09 11.88 17 72188 356 90555886
Atrial fibrillation 51.45 11.88 227 71978 133384 90422858
Bronchitis 50.92 11.88 249 71956 152678 90403564
Dyspnoea at rest 50.87 11.88 37 72168 4754 90551488
Red blood cell sedimentation rate increased 50.63 11.88 4 72201 82591 90473651
Pain 50.60 11.88 529 71676 995812 89560430
Feeling abnormal 50.57 11.88 265 71940 166970 90389272
Sleep disorder 50.40 11.88 50 72155 197980 90358262
Atrial flutter 50.33 11.88 52 72153 10706 90545536
Left ventricular failure 49.99 11.88 42 72163 6658 90549584
Interstitial lung disease 49.87 11.88 154 72051 76251 90479991
Product dose omission issue 49.80 11.88 400 71805 291287 90264955
Subcutaneous emphysema 49.56 11.88 22 72183 1090 90555152
Neutropenia 49.39 11.88 64 72141 224840 90331402
Catheter site rash 49.09 11.88 20 72185 800 90555442
Hospitalisation 48.84 11.88 217 71988 127883 90428359
Haemoglobin decreased 48.53 11.88 256 71949 161700 90394542
Infusion site erythema 48.25 11.88 57 72148 13613 90542629
Exposure during pregnancy 48.20 11.88 72 72133 238338 90317904
Device leakage 48.02 11.88 49 72156 9942 90546300
Abdominal discomfort 47.60 11.88 207 71998 477121 90079121
Pulmonary arterial pressure abnormal 47.50 11.88 18 72187 592 90555650
Malaise 45.98 11.88 688 71517 585298 89970944
Pneumothorax 45.89 11.88 66 72139 19101 90537141
Transplant evaluation 45.54 11.88 22 72183 1324 90554918
Prescribed overdose 45.29 11.88 11 72194 97614 90458628
Rales 44.67 11.88 59 72146 15768 90540474
Knee arthroplasty 43.56 11.88 7 72198 83175 90473067
Injection site reaction 43.46 11.88 10 72195 92070 90464172
Obesity 43.24 11.88 15 72190 105492 90450750
Confusional state 43.22 11.88 160 72045 386045 90170197
Wound infection 42.13 11.88 16 72189 106386 90449856
Peripheral venous disease 41.90 11.88 8 72197 83913 90472329
Respiratory tract infection 41.30 11.88 122 72083 58956 90497286
Night sweats 40.94 11.88 26 72179 128740 90427502
Suicide attempt 40.27 11.88 6 72199 75393 90480849
Device occlusion 40.10 11.88 43 72162 9239 90547003
Paraesthesia 39.53 11.88 88 72117 250238 90306004
Pulmonary congestion 39.52 11.88 62 72143 19371 90536871
Hypoaesthesia 39.33 11.88 124 72081 314086 90242156
Intentional overdose 39.04 11.88 13 72192 93821 90462421
Device connection issue 38.99 11.88 18 72187 978 90555264
Sepsis 38.32 11.88 260 71945 179554 90376688
Oedema 37.68 11.88 281 71924 200014 90356228
Ascites 37.68 11.88 103 72102 47637 90508605
Emphysema 36.94 11.88 47 72158 12108 90544134
Autoimmune disorder 36.89 11.88 8 72197 76736 90479506
Pulmonary hypertensive crisis 36.87 11.88 14 72191 463 90555779
Drug abuse 36.82 11.88 10 72195 82337 90473905
Gastrointestinal haemorrhage 36.78 11.88 156 72049 90092 90466150
Epilepsy 36.72 11.88 10 72195 82196 90474046
Catheter site swelling 36.53 11.88 21 72184 1804 90554438
Device infusion issue 36.35 11.88 24 72181 2638 90553604
Hypertension 36.17 11.88 215 71990 457317 90098925
Gait inability 36.10 11.88 38 72167 146418 90409824
Abdominal distension 35.46 11.88 201 72004 130400 90425842
Central venous catheterisation 35.36 11.88 24 72181 2762 90553480
Live birth 34.64 11.88 10 72195 79097 90477145
Gastrointestinal disorder 34.49 11.88 98 72107 256589 90299653
Pneumomediastinum 34.45 11.88 21 72184 2010 90554232
Aspiration pleural cavity 34.13 11.88 16 72189 900 90555342
Catheter site haemorrhage 33.75 11.88 26 72179 3642 90552600
Nasal dryness 33.64 11.88 31 72174 5552 90550690
Platelet count decreased 33.44 11.88 205 72000 136764 90419478
Oxygen consumption 32.94 11.88 9 72196 99 90556143
Paracentesis 32.87 11.88 16 72189 979 90555263
Illness 32.87 11.88 141 72064 81828 90474414
Haematocrit decreased 32.76 11.88 90 72115 41742 90514500
Tachypnoea 32.74 11.88 60 72145 21249 90534993
Catheter site scab 32.74 11.88 11 72194 253 90555989
Sputum discoloured 32.07 11.88 58 72147 20333 90535909
Prescribed underdose 31.91 11.88 10 72195 75009 90481233
Colitis ulcerative 31.72 11.88 5 72200 60261 90495981
Cardiac pacemaker insertion 31.59 11.88 27 72178 4380 90551862
Sciatica 31.51 11.88 21 72184 101361 90454881
Cardiomegaly 31.27 11.88 55 72150 18870 90537372
Gamma-glutamyltransferase increased 31.07 11.88 83 72122 37869 90518373
Carbon dioxide increased 30.82 11.88 19 72186 1856 90554386
Depression 30.76 11.88 129 72076 300472 90255770
Seasonal allergy 30.73 11.88 61 72144 22922 90533320
Premature baby 30.50 11.88 64 72141 25013 90531229
Product use in unapproved indication 30.42 11.88 151 72054 336085 90220157
Catheter placement 30.28 11.88 21 72184 2503 90553739
Rhinorrhoea 30.25 11.88 145 72060 88171 90468071
Gastrointestinal disorder congenital 30.01 11.88 9 72196 141 90556101
Apgar score low 30 11.88 16 72189 1187 90555055
Vascular device infection 29.86 11.88 42 72163 11910 90544332
Throat irritation 29.80 11.88 96 72109 48599 90507643
Oedematous kidney 29.67 11.88 9 72196 147 90556095
Bladder agenesis 29.50 11.88 9 72196 150 90556092
N-terminal prohormone brain natriuretic peptide increased 29.48 11.88 22 72183 2940 90553302
Chills 29.41 11.88 193 72012 131788 90424454
Loss of consciousness 29.41 11.88 202 72003 140036 90416206
Pulmonary function test decreased 29.13 11.88 26 72179 4468 90551774
Foot deformity 29.12 11.88 6 72199 59645 90496597
Cloacal exstrophy 29.12 11.88 9 72196 157 90556085
Genitalia external ambiguous 29.12 11.88 9 72196 157 90556085
Supraventricular tachycardia 28.98 11.88 49 72156 16287 90539955
Congenital genital malformation 28.75 11.88 9 72196 164 90556078
General physical health deterioration 28.51 11.88 166 72039 354949 90201293
Blood iron decreased 28.14 11.88 51 72154 17908 90538334
Congenital ectopic bladder 27.99 11.88 8 72197 105 90556137
Respiratory syncytial virus infection 27.94 11.88 38 72167 10442 90545800
Hip arthroplasty 27.70 11.88 13 72192 76195 90480047
Nocturnal dyspnoea 27.31 11.88 16 72189 1424 90554818
Secretion discharge 27.31 11.88 47 72158 15849 90540393
Walking distance test abnormal 27.29 11.88 12 72193 581 90555661
Gastrointestinal malformation 26.95 11.88 9 72196 203 90556039
Meconium stain 26.87 11.88 9 72196 205 90556037
Congestive hepatopathy 26.83 11.88 21 72184 3012 90553230
Right ventricular dysfunction 26.80 11.88 19 72186 2345 90553897
Exostosis 26.66 11.88 5 72200 53129 90503113
Lipodystrophy acquired 26.57 11.88 16 72189 1498 90554744
Taste disorder 26.54 11.88 8 72197 61538 90494704
Bronchospasm 26.54 11.88 54 72151 20655 90535587
Pulseless electrical activity 26.30 11.88 34 72171 8898 90547344
Weight decreased 26.30 11.88 437 71768 379473 90176769
Pneumonia bacterial 26.28 11.88 41 72164 12749 90543493
Accident 26.22 11.88 30 72175 6924 90549318
Onychomadesis 26.15 11.88 3 72202 45995 90510247
Anaesthetic complication 26.09 11.88 19 72186 2446 90553796
Injection site erythema 26.06 11.88 24 72181 98478 90457764
Adverse drug reaction 25.82 11.88 33 72172 116668 90439574
Aspartate aminotransferase increased 25.72 11.88 155 72050 102782 90453460
Dry mouth 25.67 11.88 69 72136 183990 90372252
Neuromuscular blockade 25.64 11.88 10 72195 356 90555886
Localised oedema 25.54 11.88 28 72177 6166 90550076
Gout 25.31 11.88 47 72158 16812 90539430
Pregnancy 25.11 11.88 9 72196 62038 90494204
Cardiac ablation 24.83 11.88 16 72189 1688 90554554
Disease progression 24.67 11.88 211 71994 156404 90399838
Stent placement 24.67 11.88 23 72182 4180 90552062
Pulmonary haemorrhage 24.37 11.88 31 72174 7982 90548260
Tethered cord syndrome 24.07 11.88 9 72196 285 90555957
Febrile neutropenia 23.91 11.88 57 72148 158292 90397950
Caudal regression syndrome 23.53 11.88 8 72197 191 90556051
Cognitive disorder 23.49 11.88 13 72192 69394 90486848
Device maintenance issue 23.26 11.88 8 72197 198 90556044
Neural tube defect 23.18 11.88 8 72197 200 90556042
Concomitant disease progression 23.16 11.88 17 72188 2215 90554027
Dermatitis contact 23.10 11.88 40 72165 13555 90542687
Idiopathic pulmonary fibrosis 23.00 11.88 15 72190 1615 90554627
Pulmonary trichosporonosis 22.85 11.88 6 72199 56 90556186
Coeliac disease 22.81 11.88 4 72201 44606 90511636
Joint dislocation 22.79 11.88 4 72201 44578 90511664
Iron deficiency anaemia 22.75 11.88 55 72150 23607 90532635
Rehabilitation therapy 22.69 11.88 16 72189 1958 90554284
Upper respiratory tract inflammation 22.56 11.88 18 72187 2654 90553588
Increased ventricular preload 22.27 11.88 5 72200 22 90556220
Blood potassium decreased 22.23 11.88 86 72119 47641 90508601
Hepatic function abnormal 22.04 11.88 84 72121 46204 90510038
Infusion site swelling 21.92 11.88 36 72169 11684 90544558
Complication associated with device 21.78 11.88 48 72157 19401 90536841
Terminal state 21.72 11.88 18 72187 2800 90553442
Argon plasma coagulation 21.58 11.88 5 72200 26 90556216
Mediastinal effusion 21.56 11.88 6 72199 71 90556171
Tachycardia 21.56 11.88 206 71999 157467 90398775
Hepatitis 21.52 11.88 15 72190 70724 90485518
Pulmonary alveolar haemorrhage 21.15 11.88 25 72180 5973 90550269
Ventilation perfusion mismatch 21.01 11.88 10 72195 582 90555660
Rhinocerebral mucormycosis 20.82 11.88 11 72194 801 90555441
Fall 20.63 11.88 516 71689 481294 90074948
Lung adenocarcinoma stage IV 20.37 11.88 9 72196 441 90555801
Anal atresia 20.37 11.88 9 72196 441 90555801
Pancreatitis haemorrhagic 20.14 11.88 10 72195 639 90555603
Cardiac failure high output 20.10 11.88 9 72196 455 90555787
Infusion site haemorrhage 19.82 11.88 23 72182 5388 90550854
Infusion site discharge 19.70 11.88 16 72189 2419 90553823
Head injury 19.55 11.88 62 72143 31126 90525116
Pulmonary artery banding 19.54 11.88 4 72201 10 90556232
Tricuspid valve incompetence 19.54 11.88 42 72163 16689 90539553
Suicidal ideation 19.53 11.88 18 72187 73837 90482405
Paradoxical embolism 19.41 11.88 5 72200 43 90556199
Craniotomy 19.29 11.88 8 72197 335 90555907
Acute postoperative sialadenitis 19.10 11.88 5 72200 46 90556196
Amnesia 18.93 11.88 36 72169 108469 90447773
Bradycardia 18.91 11.88 123 72082 83724 90472518
Hyperandrogenism 18.88 11.88 6 72199 115 90556127
Rhonchi 18.85 11.88 17 72188 2961 90553281
Leukopenia 18.84 11.88 32 72173 100678 90455564
Pulmonary capillary haemangiomatosis 18.82 11.88 5 72200 49 90556193
Blood immunoglobulin E 18.82 11.88 5 72200 49 90556193
Lung assist device therapy 18.69 11.88 6 72199 119 90556123
Pulmonary artery dilatation 18.64 11.88 8 72197 365 90555877
PO2 decreased 18.61 11.88 13 72192 1568 90554674
Oedematous pancreatitis 18.35 11.88 10 72195 775 90555467
Limb injury 18.27 11.88 61 72144 31447 90524795
Pulmonary nocardiosis 18.19 11.88 10 72195 788 90555454
Middle ear effusion 18.15 11.88 16 72189 2705 90553537
Anencephaly 18.14 11.88 8 72197 390 90555852
Right ventricular systolic pressure increased 17.97 11.88 9 72196 586 90555656
Cardioversion 17.86 11.88 12 72193 1358 90554884
Musculoskeletal pain 17.81 11.88 73 72132 171178 90385064
Heart rate irregular 17.81 11.88 51 72154 24217 90532025
Accidental underdose 17.79 11.88 11 72194 1080 90555162
Apnoea 17.72 11.88 29 72176 9385 90546857
Sepsis neonatal 17.71 11.88 9 72196 604 90555638
Road traffic accident 17.67 11.88 37 72168 107589 90448653
Influenza 17.60 11.88 179 72026 139085 90417157
Enlarged clitoris 17.58 11.88 6 72199 145 90556097
Platelet transfusion 17.52 11.88 11 72194 1109 90555133
Meningomyelocele 17.32 11.88 9 72196 633 90555609
Breath sounds abnormal 17.26 11.88 38 72167 15348 90540894
Uterine hypotonus 17.24 11.88 6 72199 154 90556088
Increased bronchial secretion 17.11 11.88 14 72191 2139 90554103
Hospice care 17.07 11.88 29 72176 9675 90546567
Abdominal cavity drainage 17.03 11.88 8 72197 452 90555790
Angioedema 16.93 11.88 16 72189 64860 90491382
Diarrhoea 16.92 11.88 912 71293 938278 89617964
Blood urea increased 16.86 11.88 58 72147 30355 90525887
Lower limb fracture 16.85 11.88 26 72179 84987 90471255
Umbilical cord abnormality 16.81 11.88 9 72196 673 90555569
Liver function test increased 16.77 11.88 26 72179 84829 90471413
Finger deformity 16.71 11.88 3 72202 32894 90523348
Choking sensation 16.57 11.88 18 72187 3924 90552318
Injection site swelling 16.53 11.88 14 72191 59825 90496417
Burns third degree 16.53 11.88 7 72198 309 90555933
Red blood cell count decreased 16.52 11.88 77 72128 46274 90509968
Catheter site inflammation 16.50 11.88 10 72195 947 90555295
Laryngitis 16.47 11.88 10 72195 50743 90505499
Haematocrit increased 16.46 11.88 16 72189 3062 90553180
Barotrauma 16.45 11.88 6 72199 177 90556065
Infection 16.40 11.88 197 72008 361897 90194345
Oxygen consumption decreased 16.34 11.88 7 72198 318 90555924
Cold burn 16.33 11.88 3 72202 3 90556239
Tracheostomy 16.27 11.88 9 72196 718 90555524
Systemic scleroderma 16.26 11.88 12 72193 1577 90554665
Procedural hypotension 16.18 11.88 12 72193 1588 90554654
Therapy change 16.16 11.88 26 72179 8296 90547946
Multiple sclerosis relapse 16.03 11.88 11 72194 52294 90503948
Cellulitis 15.96 11.88 126 72079 91211 90465031
Echocardiogram 15.89 11.88 4 72201 31 90556211
Liver disorder 15.77 11.88 47 72158 121222 90435020
Device wireless communication issue 15.73 11.88 5 72200 96 90556146
Malignant neoplasm progression 15.71 11.88 39 72166 106831 90449411
Dysbiosis 15.52 11.88 12 72193 1690 90554552
Deafness bilateral 15.45 11.88 12 72193 1701 90554541
Vasodilatation 15.44 11.88 15 72190 2869 90553373
Device failure 15.43 11.88 23 72182 6874 90549368
Exomphalos 15.42 11.88 8 72197 561 90555681
Infusion site abscess 15.38 11.88 7 72198 368 90555874
Gastrointestinal arteriovenous malformation 15.34 11.88 8 72197 567 90555675
Mucosal inflammation 15.29 11.88 14 72191 57611 90498631
Jugular vein distension 15.28 11.88 10 72195 1083 90555159
Catheter site hypersensitivity 15.26 11.88 5 72200 106 90556136
Catheter site warmth 15.22 11.88 6 72199 220 90556022
Frostbite 15.17 11.88 6 72199 222 90556020
Sputum increased 15.12 11.88 15 72190 2942 90553300
Dialysis 15.06 11.88 30 72175 11299 90544943
Stress cardiomyopathy 15.00 11.88 33 72172 13322 90542920
Faeces discoloured 14.87 11.88 44 72161 21276 90534966
Atrioventricular block second degree 14.79 11.88 18 72187 4434 90551808
Catheter site vesicles 14.78 11.88 7 72198 403 90555839
Retching 14.78 11.88 41 72164 19118 90537124
Immunodeficiency 14.77 11.88 8 72197 43226 90513016
Meningitis cryptococcal 14.74 11.88 12 72193 1821 90554421
Acute right ventricular failure 14.73 11.88 6 72199 240 90556002
Multiple organ dysfunction syndrome 14.65 11.88 99 72106 68237 90488005
Device use error 14.63 11.88 23 72182 7198 90549044
Dizziness postural 14.55 11.88 26 72179 9027 90547215
Biopsy liver 14.54 11.88 7 72198 418 90555824
Oropharyngeal pain 14.52 11.88 148 72057 115039 90441203
Contusion 14.52 11.88 129 72076 251087 90305155
Toxic epidermal necrolysis 14.45 11.88 4 72201 32524 90523718
Joint stiffness 14.41 11.88 25 72180 78017 90478225
Device issue 14.39 11.88 54 72151 29483 90526759
Blood alkaline phosphatase increased 14.39 11.88 76 72129 48003 90508239
Device malfunction 14.35 11.88 43 72162 20934 90535308
Disease recurrence 14.35 11.88 6 72199 37647 90518595
Pulmonary pain 14.33 11.88 19 72186 5095 90551147
Respiration abnormal 14.28 11.88 24 72181 7939 90548303
Polycythaemia 14.26 11.88 10 72195 1213 90555029
Stevens-Johnson syndrome 14.24 11.88 3 72202 29373 90526869
Neoplasm progression 14.11 11.88 9 72196 44477 90511765
Urine output decreased 13.99 11.88 31 72174 12572 90543670
Atelectasis 13.93 11.88 47 72158 24362 90531880
Upper respiratory tract infection 13.92 11.88 160 72045 128158 90428084
Respiratory tract haemorrhage 13.83 11.88 7 72198 466 90555776
Decreased activity 13.78 11.88 24 72181 8168 90548074
Device related sepsis 13.73 11.88 18 72187 4775 90551467
Osteonecrosis of jaw 13.71 11.88 7 72198 39096 90517146
Swollen tongue 13.64 11.88 10 72195 45946 90510296
Sinus disorder 13.61 11.88 59 72146 34388 90521854
Osteoporosis 13.59 11.88 36 72169 96495 90459747
Nausea 13.58 11.88 1043 71162 1109273 89446969
Overdose 13.58 11.88 72 72133 157637 90398605
Vascular cauterisation 13.50 11.88 4 72201 60 90556182
Injection site pain 13.50 11.88 82 72123 173617 90382625
Compartment syndrome 13.49 11.88 14 72191 2898 90553344
Pneumonia mycoplasmal 13.44 11.88 9 72196 1013 90555229
Right ventricular dilatation 13.40 11.88 11 72194 1688 90554554
Administration site pruritus 13.30 11.88 6 72199 309 90555933
Mastitis bacterial 13.26 11.88 4 72201 64 90556178
Catheter site erosion 13.20 11.88 4 72201 65 90556177
Pulmonary thrombosis 13.12 11.88 26 72179 9756 90546486
Pneumoperitoneum 13.10 11.88 11 72194 1742 90554500
Dizziness exertional 13.05 11.88 7 72198 525 90555717
Gastric dilatation 13.01 11.88 10 72195 1397 90554845
Post procedural complication 13.00 11.88 39 72166 19003 90537239
Lung squamous cell carcinoma stage I 12.88 11.88 3 72202 16 90556226
Muscle spasticity 12.87 11.88 6 72199 35316 90520926
Mouth ulceration 12.80 11.88 8 72197 39966 90516276
Back injury 12.76 11.88 11 72194 46611 90509631
Unevaluable device issue 12.73 11.88 3 72202 17 90556225
Right ventricular hypertrophy 12.72 11.88 8 72197 809 90555433
Choking 12.69 11.88 29 72176 12004 90544238
Myalgia 12.67 11.88 203 72002 174922 90381320
Respiratory acidosis 12.65 11.88 23 72182 8096 90548146
Brain hypoxia 12.61 11.88 7 72198 562 90555680
Agonal respiration 12.59 11.88 5 72200 187 90556055
Oxygen saturation increased 12.56 11.88 6 72199 352 90555890
Asthenia 12.48 11.88 532 71673 533219 90023023
Drug-induced liver injury 12.48 11.88 34 72171 90284 90465958
Candida infection 12.45 11.88 57 72148 34000 90522242
Colitis 12.38 11.88 23 72182 69919 90486323
Renal failure 12.32 11.88 159 72046 130848 90425394
Acute pulmonary oedema 12.30 11.88 25 72180 9555 90546687
Upper-airway cough syndrome 12.28 11.88 33 72172 15102 90541140
Condition aggravated 12.27 11.88 586 71619 594959 89961283
Adverse event 12.24 11.88 50 72155 117368 90438874
Device physical property issue 12.24 11.88 13 72192 2763 90553479
Therapeutic response decreased 12.23 11.88 34 72171 89695 90466547
Spina bifida 12.18 11.88 8 72197 872 90555370
Patient dissatisfaction with device 12.16 11.88 4 72201 86 90556156
Renal disorder 12.13 11.88 61 72144 37798 90518444
Rhinovirus infection 12.09 11.88 19 72186 5944 90550298
CREST syndrome 12.08 11.88 7 72198 610 90555632
Lung infiltration 12.08 11.88 33 72172 15249 90540993
Catheter removal 12.02 11.88 6 72199 388 90555854
Hypoacusis 12.01 11.88 49 72156 27801 90528441
Arthritis 11.97 11.88 81 72124 167234 90389008
Biopsy bone marrow 11.93 11.88 6 72199 394 90555848
Drug titration error 11.89 11.88 9 72196 1228 90555014

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 422.10 11.88 1073 35799 441548 42142915
Oxygen saturation decreased 386.18 11.88 370 36502 64317 42520146
Pulmonary arterial hypertension 339.34 11.88 169 36703 10018 42574445
Hypoxia 271.64 11.88 318 36554 69468 42514995
Right ventricular failure 217.55 11.88 123 36749 9432 42575031
Respiratory failure 203.73 11.88 383 36489 127749 42456714
Pulmonary hypertension 202.77 11.88 166 36706 23403 42561060
Oxygen consumption increased 184.34 11.88 65 36807 1594 42582869
Chronic obstructive pulmonary disease 140.17 11.88 219 36653 62895 42521568
Fluid retention 134.53 11.88 151 36721 31468 42552995
Pneumonia 118.25 11.88 694 36178 421455 42163008
Idiopathic pulmonary fibrosis 114.98 11.88 63 36809 4541 42579922
Thermal burn 113.33 11.88 54 36818 2900 42581563
Acute respiratory failure 111.16 11.88 152 36720 38706 42545757
Concomitant disease aggravated 108.84 11.88 69 36803 6517 42577946
Dyspnoea exertional 96.34 11.88 163 36709 49985 42534478
Pain in jaw 84.55 11.88 82 36790 14420 42570043
Brain scan abnormal 81.18 11.88 33 36839 1206 42583257
Cerebral artery thrombosis 80.92 11.88 33 36839 1216 42583247
Cough 79.71 11.88 335 36537 177768 42406695
Toxicity to various agents 78.29 11.88 51 36821 229085 42355378
Hypervolaemia 76.22 11.88 97 36775 23028 42561435
Respiratory distress 72.58 11.88 130 36742 41690 42542773
Drug ineffective 63.83 11.88 305 36567 629892 41954571
Pneumothorax 59.75 11.88 87 36785 23456 42561007
Pulmonary oedema 59.55 11.88 138 36734 53134 42531329
Completed suicide 59.18 11.88 7 36865 96458 42488005
Nasal congestion 56.77 11.88 96 36776 29405 42555058
Oxygen therapy 55.71 11.88 26 36846 1332 42583131
Hypercapnia 55.20 11.88 42 36830 5319 42579144
Areflexia 53.96 11.88 36 36836 3707 42580756
Transfusion 53.10 11.88 55 36817 10459 42574004
Haemoglobin increased 51.88 11.88 40 36832 5166 42579297
Pulmonary arterial pressure increased 49.67 11.88 25 36847 1513 42582950
Drug abuse 48.73 11.88 15 36857 104756 42479707
Accidental underdose 47.86 11.88 19 36853 652 42583811
Neutropenia 46.22 11.88 63 36809 199368 42385095
Oedema 43.79 11.88 121 36751 51880 42532583
Subcutaneous emphysema 41.61 11.88 23 36849 1686 42582777
Burns third degree 37.92 11.88 12 36860 208 42584255
Blood pressure decreased 37.12 11.88 123 36749 58209 42526254
Brain natriuretic peptide increased 37.07 11.88 37 36835 6733 42577730
Lung transplant 36.95 11.88 24 36848 2362 42582101
Haemoptysis 36.49 11.88 105 36767 46062 42538401
Cardiac arrest 35.86 11.88 188 36684 109132 42475331
Respiratory tract infection 33.69 11.88 72 36800 26250 42558213
Chronic respiratory failure 33.44 11.88 20 36852 1702 42582761
Emphysema 33.37 11.88 46 36826 11789 42572674
Cyanosis 33.10 11.88 52 36820 14979 42569484
Neuromuscular block prolonged 32.23 11.88 14 36858 605 42583858
Productive cough 32.15 11.88 108 36764 51459 42533004
Pulmonary veno-occlusive disease 31.99 11.88 14 36858 616 42583847
Oedema peripheral 31.75 11.88 214 36658 135862 42448601
Catheter management 31.07 11.88 16 36856 1016 42583447
Accident 31.02 11.88 33 36839 6470 42577993
Catheter site erythema 30.36 11.88 19 36853 1754 42582709
Hemiplegia 29.09 11.88 35 36837 7844 42576619
Hypotension 28.38 11.88 344 36528 257287 42327176
Cor pulmonale 28.34 11.88 14 36858 814 42583649
Respiratory acidosis 28.22 11.88 31 36841 6300 42578163
Ventilation perfusion mismatch 28.18 11.88 9 36863 161 42584302
Cardiac failure 27.95 11.88 173 36699 106683 42477780
Transplant evaluation 27.79 11.88 12 36860 511 42583952
Epistaxis 27.73 11.88 123 36749 66703 42517760
Pulmonary fibrosis 27.51 11.88 67 36805 26614 42557849
Treatment failure 27.31 11.88 10 36862 62614 42521849
Pneumomediastinum 26.89 11.88 22 36850 3094 42581369
Catheter placement 26.59 11.88 14 36858 931 42583532
Intentional overdose 26.51 11.88 6 36866 51450 42533013
Catheter site haemorrhage 26.32 11.88 20 36852 2528 42581935
Catheter removal 26.18 11.88 9 36863 204 42584259
Mechanical ventilation 26.04 11.88 19 36853 2258 42582205
Pulmonary function test decreased 25.44 11.88 28 36844 5704 42578759
COVID-19 pneumonia 25.25 11.88 57 36815 21556 42562907
Air embolism 24.81 11.88 9 36863 240 42584223
Rhinocerebral mucormycosis 24.61 11.88 12 36860 678 42583785
Disseminated strongyloidiasis 24.47 11.88 11 36861 516 42583947
Catheter site pain 23.60 11.88 16 36856 1691 42582772
Pulmonary function test abnormal 23.20 11.88 19 36853 2675 42581788
Pulmonary haemorrhage 23.14 11.88 38 36834 11359 42573104
Stress 23.09 11.88 5 36867 44207 42540256
Procedural complication 22.99 11.88 23 36849 4196 42580267
Carbon dioxide increased 22.71 11.88 14 36858 1258 42583205
Headache 22.71 11.88 311 36561 239058 42345405
Catheterisation cardiac 22.60 11.88 19 36853 2775 42581688
White blood cell count decreased 22.53 11.88 38 36834 110358 42474105
Respiratory disorder 22.28 11.88 55 36817 22030 42562433
Infusion site erythema 22.09 11.88 21 36851 3601 42580862
Infusion site pain 21.63 11.88 25 36847 5370 42579093
Dependence on oxygen therapy 21.62 11.88 8 36864 226 42584237
Confusional state 21.29 11.88 74 36798 167523 42416940
Pulmonary congestion 21.26 11.88 44 36828 15686 42568777
Interstitial lung disease 21.12 11.88 128 36744 78334 42506129
Drug interaction 21.00 11.88 140 36732 266859 42317604
Condition aggravated 20.89 11.88 329 36543 260425 42324038
Subacute combined cord degeneration 20.82 11.88 7 36865 148 42584315
Lung disorder 20.48 11.88 89 36783 47834 42536629
Haemodynamic instability 20.46 11.88 38 36834 12519 42571944
Complication associated with device 20.41 11.88 27 36845 6654 42577809
Bronchopulmonary aspergillosis 20.25 11.88 49 36823 19380 42565083
Cardiac failure congestive 20.17 11.88 135 36737 85467 42498996
Therapeutic product effect incomplete 20.12 11.88 19 36853 70920 42513543
Barotrauma 20.03 11.88 5 36867 34 42584429
Abdominal pain 19.82 11.88 91 36781 190380 42394083
Catheter site discharge 19.80 11.88 11 36861 814 42583649
Walking distance test abnormal 19.54 11.88 7 36865 180 42584283
PaO2/FiO2 ratio decreased 19.43 11.88 5 36867 39 42584424
Aggression 19.34 11.88 7 36865 44156 42540307
Oxygen saturation abnormal 19.32 11.88 15 36857 1956 42582507
Catheter site granuloma 19.32 11.88 5 36867 40 42584423
Pancreatitis acute 19.24 11.88 3 36869 33561 42550902
Frostbite 19.00 11.88 5 36867 43 42584420
Pulmonary hypertensive crisis 18.81 11.88 7 36865 201 42584262
Catheter site pruritus 18.72 11.88 8 36864 332 42584131
Apnoea 18.59 11.88 28 36844 7775 42576688
Rotavirus infection 18.38 11.88 9 36863 513 42583950
Coma 18.14 11.88 12 36860 53542 42530921
Rash maculo-papular 18.10 11.88 5 36867 37498 42546965
Facial paralysis 17.99 11.88 36 36836 12527 42571936
Tracheal injury 17.89 11.88 5 36867 55 42584408
Dyspnoea at rest 17.56 11.88 20 36852 4229 42580234
Acute right ventricular failure 17.54 11.88 6 36866 134 42584329
Malassezia infection 17.50 11.88 5 36867 60 42584403
Thrombocytopenia 17.46 11.88 95 36777 190184 42394279
Bradycardia 17.33 11.88 130 36742 85354 42499109
Hyponatraemia 17.17 11.88 39 36833 101423 42483040
Rectal haemorrhage 16.95 11.88 11 36861 49595 42534868
Periarthritis 16.89 11.88 12 36860 1368 42583095
Sedation 16.85 11.88 3 36869 30472 42553991
Tachypnoea 16.85 11.88 49 36823 21613 42562850
Cardiac assistance device user 16.66 11.88 5 36867 72 42584391
Rheumatoid arthritis 16.54 11.88 8 36864 42432 42542031
Anaesthetic complication 16.30 11.88 12 36860 1445 42583018
Syncope 16.28 11.88 144 36728 99262 42485201
Delayed recovery from anaesthesia 16.27 11.88 11 36861 1158 42583305
Bronchospasm 16.20 11.88 35 36837 12850 42571613
Cytomegalovirus infection 16.18 11.88 4 36868 32302 42552161
Thyroglobulin increased 16.18 11.88 4 36868 26 42584437
Hyperoxia 16.08 11.88 3 36869 3 42584460
Infusion site vesicles 16.07 11.88 6 36866 174 42584289
Flushing 16.00 11.88 69 36803 36959 42547504
Pneumonia cryptococcal 15.93 11.88 12 36860 1496 42582967
Febrile neutropenia 15.80 11.88 95 36777 185608 42398855
Anaesthetic complication cardiac 15.80 11.88 4 36868 29 42584434
Superinfection fungal 15.68 11.88 4 36868 30 42584433
Tubulointerstitial nephritis 15.62 11.88 4 36868 31544 42552919
Pulse pressure decreased 15.60 11.88 6 36866 189 42584274
Alkalosis hypochloraemic 15.58 11.88 7 36865 328 42584135
Acute kidney injury 15.57 11.88 224 36648 367113 42217350
Thoracic cavity drainage 15.54 11.88 6 36866 191 42584272
Mucosal inflammation 15.49 11.88 12 36860 49362 42535101
Hyperthermia malignant 15.43 11.88 15 36857 2643 42581820
Catheter site infection 15.34 11.88 16 36856 3067 42581396
Bifidobacterium infection 15.32 11.88 5 36867 96 42584367
SARS-CoV-2 viraemia 15.32 11.88 5 36867 96 42584367
Bronchopulmonary dysplasia 15.24 11.88 9 36863 748 42583715
Catheter site warmth 15.23 11.88 5 36867 98 42584365
Suicidal ideation 14.74 11.88 12 36860 48149 42536314
Suicide attempt 14.73 11.88 11 36861 46089 42538374
Decompression sickness 14.56 11.88 3 36869 7 42584456
Catheter site rash 14.51 11.88 6 36866 229 42584234
Nasal dryness 14.50 11.88 11 36861 1386 42583077
Infusion site irritation 14.46 11.88 7 36865 389 42584074
Ventricular tachycardia 14.44 11.88 58 36814 30102 42554361
Heart rate increased 14.40 11.88 87 36785 53168 42531295
Intentional product use issue 14.40 11.88 25 36847 71808 42512655
Therapeutic product effect decreased 14.33 11.88 8 36864 39142 42545321
Rash 14.28 11.88 162 36710 276792 42307671
Blood cholesterol increased 14.01 11.88 3 36869 26738 42557725
Catheter site inflammation 13.88 11.88 6 36866 256 42584207
Psoriasis 13.80 11.88 13 36859 48591 42535872
Electrocardiogram ST segment elevation 13.71 11.88 21 36851 5918 42578545
Stomatitis 13.67 11.88 14 36858 50315 42534148
Hallucination 13.46 11.88 18 36854 57489 42526974
Lung infiltration 13.23 11.88 34 36838 13955 42570508
Bronchial haemorrhage 13.21 11.88 8 36864 696 42583767
Device intolerance 13.15 11.88 3 36869 13 42584450
Off label use 13.14 11.88 437 36435 637898 41946565
Pulseless electrical activity 13.08 11.88 25 36847 8412 42576051
Pulmonary alveolar haemorrhage 12.98 11.88 35 36837 14781 42569682
Rheumatoid arthritis-associated interstitial lung disease 12.80 11.88 3 36869 15 42584448
Neutrophil count decreased 12.77 11.88 22 36850 63393 42521070
Cardiac failure acute 12.75 11.88 33 36839 13600 42570863
Pulmonary artery dilatation 12.70 11.88 6 36866 316 42584147
Psoriatic arthropathy 12.68 11.88 3 36869 24964 42559499
Blood alkaline phosphatase increased 12.57 11.88 60 36812 33537 42550926
Leukopenia 12.43 11.88 29 36843 74717 42509746
Device connection issue 12.42 11.88 7 36865 533 42583930
Myotonic dystrophy 12.29 11.88 5 36867 183 42584280
Device related infection 12.22 11.88 42 36830 20237 42564226
Cerebral infarction 11.95 11.88 6 36866 31163 42553300
BRASH syndrome 11.93 11.88 11 36861 1814 42582649

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1292.35 11.27 2859 90523 1104013 109391904
Pulmonary arterial hypertension 1090.72 11.27 538 92844 32030 110463887
Oxygen saturation decreased 984.67 11.27 913 92469 156069 110339848
Pulmonary hypertension 753.02 11.27 508 92874 54712 110441205
Oxygen consumption increased 649.58 11.27 226 93156 5459 110490458
Right ventricular failure 633.94 11.27 347 93035 25607 110470310
Hypoxia 587.50 11.27 632 92750 128883 110367034
Fluid retention 513.97 11.27 508 92874 93799 110402118
Dyspnoea exertional 486.31 11.27 516 92866 103544 110392373
Respiratory failure 461.17 11.27 725 92657 214607 110281310
Chronic obstructive pulmonary disease 369.16 11.27 458 92924 108700 110387217
Hypervolaemia 359.59 11.27 313 93069 49147 110446770
Pain in jaw 296.13 11.27 285 93097 50892 110445025
Acute respiratory failure 287.48 11.27 336 93046 74924 110420993
Pneumonia 276.71 11.27 1463 91919 875251 109620666
Drug ineffective 239.36 11.27 588 92794 1519952 108975965
Transfusion 236.91 11.27 186 93196 25286 110470631
Cough 225.20 11.27 877 92505 460764 110035153
Oxygen therapy 212.12 11.27 92 93290 4061 110491856
Nasal congestion 208.84 11.27 330 93052 97952 110397965
Pulmonary oedema 201.60 11.27 329 93053 100330 110395587
Concomitant disease aggravated 188.89 11.27 136 93246 16228 110479689
Completed suicide 174.25 11.27 7 93375 242374 110253543
Oedema peripheral 169.65 11.27 636 92746 328024 110167893
Arthropathy 165.84 11.27 23 93359 287499 110208418
Toxicity to various agents 164.82 11.27 101 93281 480454 110015463
Treatment failure 160.32 11.27 22 93360 277212 110218705
Hand deformity 158.12 11.27 6 93376 218500 110277417
Cardiac failure 156.17 11.27 428 92954 187198 110308719
Therapeutic product effect decreased 154.84 11.27 14 93368 244302 110251615
Productive cough 152.00 11.27 313 93069 113992 110381925
Glossodynia 151.31 11.27 9 93373 221995 110273922
Epistaxis 148.17 11.27 335 93047 130037 110365880
Psoriatic arthropathy 147.38 11.27 4 93378 196757 110299160
Pulmonary arterial pressure increased 146.12 11.27 76 93306 5051 110490866
Blood pressure decreased 144.70 11.27 308 93074 114783 110381134
Catheter site erythema 142.75 11.27 79 93303 5949 110489968
Contraindicated product administered 140.51 11.27 21 93361 248246 110247671
Pericarditis 137.66 11.27 13 93369 219101 110276816
Rheumatoid arthritis 137.62 11.27 41 93341 299572 110196345
Duodenal ulcer perforation 135.43 11.27 3 93379 177697 110318220
Respiratory distress 135.02 11.27 223 93159 68651 110427266
Systemic lupus erythematosus 134.06 11.27 26 93356 254312 110241605
Hypercapnia 133.98 11.27 95 93287 11064 110484853
Hypotension 132.98 11.27 826 92556 523023 109972894
Alopecia 131.65 11.27 72 93310 364681 110131236
Lung transplant 124.42 11.27 69 93313 5217 110490700
Syncope 120.70 11.27 411 92971 202125 110293792
Stomatitis 120.49 11.27 39 93343 270203 110225714
Haemoptysis 120.16 11.27 216 93166 71138 110424779
Catheter site pruritus 117.50 11.27 51 93331 2255 110493662
Drug intolerance 116.58 11.27 103 93279 406409 110089508
Helicobacter infection 116.37 11.27 10 93372 181867 110314050
Hepatic enzyme increased 116.29 11.27 63 93319 320829 110175088
Thermal burn 114.84 11.27 76 93306 7912 110488005
Brain natriuretic peptide increased 113.28 11.27 86 93296 11123 110484794
Death 112.66 11.27 989 92393 697880 109798037
Rash 109.54 11.27 343 93039 820621 109675296
Infusion related reaction 107.59 11.27 98 93284 381064 110114853
Blood cholesterol increased 106.01 11.27 15 93367 184770 110311147
Drug hypersensitivity 101.69 11.27 141 93241 453949 110041968
Chest pain 101.45 11.27 603 92779 375772 110120145
Joint swelling 100.69 11.27 136 93246 442709 110053208
Irritable bowel syndrome 99.88 11.27 11 93371 164204 110331713
Pulmonary veno-occlusive disease 98.13 11.27 44 93338 2104 110493813
Neutropenia 98.00 11.27 103 93279 374517 110121400
Impaired healing 97.74 11.27 23 93359 196694 110299223
Cardiac failure congestive 97.59 11.27 315 93067 150685 110345232
Catheter management 96.90 11.27 52 93330 3683 110492234
Headache 96.41 11.27 1153 92229 881224 109614693
Musculoskeletal stiffness 95.59 11.27 59 93323 279763 110216154
Intentional product use issue 93.77 11.27 46 93336 247860 110248057
Cyanosis 91.29 11.27 119 93263 29622 110466295
Catheterisation cardiac 89.23 11.27 59 93323 6132 110489785
Wound 87.92 11.27 44 93338 234393 110261524
Idiopathic pulmonary fibrosis 87.82 11.27 54 93328 4950 110490967
Drug abuse 87.63 11.27 21 93361 177390 110318527
Pneumothorax 86.98 11.27 127 93255 35158 110460759
Fibromyalgia 84.87 11.27 20 93362 170889 110325028
Pleural effusion 84.28 11.27 335 93047 177374 110318543
Pericardial effusion 83.60 11.27 163 93219 57054 110438863
Bursitis 83.50 11.27 7 93375 129911 110366006
Scleroderma 83.18 11.27 57 93325 6284 110489633
Hypersensitivity 83.09 11.27 133 93249 403865 110092052
Mobility decreased 82.57 11.27 49 93333 237373 110258544
Infusion site pain 80.60 11.27 86 93296 17333 110478584
Liver injury 80.03 11.27 15 93367 150398 110345519
Type 2 diabetes mellitus 80.00 11.27 25 93357 177207 110318710
Dependence on oxygen therapy 79.73 11.27 28 93354 695 110495222
Urticaria 79.70 11.27 91 93291 318766 110177151
Catheter site discharge 78.76 11.27 42 93340 2937 110492980
Chronic respiratory failure 78.56 11.27 46 93336 3857 110492060
Subcutaneous emphysema 78.54 11.27 40 93342 2544 110493373
Catheter site pain 77.67 11.27 55 93327 6391 110489526
Blister 77.57 11.27 48 93334 227328 110268589
Flushing 77.42 11.27 229 93153 104507 110391410
Joint range of motion decreased 74.49 11.27 8 93374 121824 110374093
Brain scan abnormal 74.39 11.27 33 93349 1538 110494379
Chest discomfort 72.46 11.27 315 93067 173533 110322384
Discomfort 72.31 11.27 46 93336 214661 110281256
Oedema 71.74 11.27 359 93023 209617 110286300
Air embolism 71.40 11.27 25 93357 615 110495302
Catheter site infection 71.34 11.27 57 93325 7943 110487974
Device related infection 70.87 11.27 123 93259 39396 110456521
Cerebral artery thrombosis 69.36 11.27 32 93350 1636 110494281
Unevaluable event 69.27 11.27 154 93228 59073 110436844
Cardiac arrest 69.07 11.27 339 93043 196414 110299503
Device alarm issue 68.97 11.27 36 93346 2410 110493507
Off label use 66.99 11.27 880 92502 1499305 108996612
Intentional overdose 66.79 11.27 15 93367 132486 110363431
Confusional state 65.83 11.27 191 93191 468489 110027428
Oxygen saturation abnormal 65.59 11.27 47 93335 5564 110490353
Lip dry 65.41 11.27 5 93377 100078 110395839
Therapeutic product effect incomplete 63.76 11.27 57 93325 223748 110272169
Palpitations 62.95 11.27 284 93098 158928 110336989
Infusion site infection 62.81 11.27 33 93349 2239 110493678
Emphysema 62.12 11.27 80 93302 19676 110476241
Arthralgia 61.93 11.27 395 92987 779237 109716680
Heart rate increased 61.76 11.27 263 93119 143571 110352346
Transplant evaluation 60.45 11.27 30 93352 1805 110494112
Pulmonary hypertensive crisis 59.35 11.27 20 93362 437 110495480
Exercise tolerance decreased 58.36 11.27 61 93321 12006 110483911
Cardiac failure acute 56.95 11.27 85 93297 23993 110471924
Ill-defined disorder 56.48 11.27 31 93351 156822 110339095
Catheter site rash 56.27 11.27 24 93358 1016 110494901
Psoriasis 55.99 11.27 24 93358 139969 110355948
Hypercholesterolaemia 55.44 11.27 6 93376 90831 110405086
Inflammation 55.30 11.27 49 93333 193189 110302728
C-reactive protein increased 54.64 11.27 62 93320 217857 110278060
Dizziness 54.27 11.27 859 92523 697334 109798583
Accidental underdose 54.15 11.27 25 93357 1280 110494637
Pneumomediastinum 53.92 11.27 40 93342 4996 110490921
Catheter placement 53.66 11.27 34 93348 3286 110492631
Injury 53.11 11.27 43 93339 177222 110318695
Catheter site haemorrhage 52.65 11.27 42 93340 5838 110490079
Osteoarthritis 52.63 11.27 46 93336 182577 110313340
Pulmonary congestion 52.45 11.27 94 93288 30872 110465045
Lower respiratory tract infection 51.89 11.27 78 93304 243028 110252889
Cor pulmonale 51.42 11.27 29 93353 2265 110493652
Red blood cell sedimentation rate increased 50.92 11.27 4 93378 78298 110417619
Dyspnoea at rest 49.24 11.27 47 93335 8299 110487618
Pruritus 49.07 11.27 289 93093 581271 109914646
Peripheral venous disease 47.83 11.27 7 93375 84110 110411807
Obesity 47.67 11.27 18 93364 113333 110382584
Pulmonary function test decreased 47.58 11.27 47 93335 8653 110487264
Grip strength decreased 47.18 11.27 6 93376 80168 110415749
Orthopnoea 46.79 11.27 52 93330 10969 110484948
Pulseless electrical activity 46.75 11.27 64 93318 16693 110479224
Interstitial lung disease 46.01 11.27 236 93146 139098 110356819
Colitis ulcerative 45.02 11.27 6 93376 77357 110418560
Respiratory tract infection 44.98 11.27 148 93234 71469 110424448
Atrial fibrillation 44.39 11.27 339 93043 229303 110266614
Device occlusion 43.89 11.27 59 93323 15126 110480791
Hospitalisation 43.38 11.27 236 93146 142257 110353660
Night sweats 43.35 11.27 30 93352 133953 110361964
Infusion site erythema 43.33 11.27 52 93330 11907 110484010
Hypertension 43.28 11.27 253 93129 509831 109986086
Nasal dryness 43.25 11.27 37 93345 5669 110490248
Carbon dioxide increased 43.18 11.27 28 93354 2816 110493101
Suicide attempt 42.52 11.27 17 93365 103377 110392540
Device connection issue 42.48 11.27 21 93361 1253 110494664
Pulmonary arterial pressure abnormal 41.88 11.27 19 93363 934 110494983
Bronchitis 41.84 11.27 251 93131 156781 110339136
Rhinocerebral mucormycosis 41.84 11.27 22 93360 1495 110494422
Ventilation perfusion mismatch 41.83 11.27 18 93364 779 110495138
Wound infection 41.10 11.27 15 93367 96450 110399467
Depression 40.50 11.27 135 93247 317200 110178717
Feeling abnormal 40.24 11.27 276 93106 180435 110315482
Sleep disorder 40.23 11.27 66 93316 198578 110297339
Pulmonary haemorrhage 40.22 11.27 59 93323 16397 110479520
Neuromuscular block prolonged 39.94 11.27 20 93362 1227 110494690
Product dose omission issue 39.70 11.27 431 92951 321351 110174566
Walking distance test abnormal 39.65 11.27 17 93365 729 110495188
Tachypnoea 39.03 11.27 96 93286 39299 110456618
Atrial flutter 39.00 11.27 72 93310 24190 110471727
Febrile neutropenia 38.91 11.27 137 93245 316630 110179287
Left ventricular failure 38.79 11.27 48 93334 11341 110484576
Cardiac disorder 37.92 11.27 146 93236 76134 110419783
Cardiomegaly 37.79 11.27 79 93303 29051 110466866
Mucosal inflammation 37.63 11.27 17 93365 96124 110399793
Anaesthetic complication 37.17 11.27 28 93354 3578 110492339
N-terminal prohormone brain natriuretic peptide increased 37.12 11.27 35 93347 6086 110489831
Live birth 36.80 11.27 7 93375 69477 110426440
Secretion discharge 36.28 11.27 63 93319 20181 110475736
Presyncope 36.22 11.27 107 93275 48780 110447137
Injection site reaction 36.05 11.27 15 93367 89055 110406862
Areflexia 35.97 11.27 36 93346 6733 110489184
Burns third degree 35.63 11.27 14 93368 479 110495438
Barotrauma 35.22 11.27 11 93371 187 110495730
Pain 34.87 11.27 582 92800 954373 109541544
Respiratory acidosis 34.41 11.27 50 93332 13776 110482141
Paraesthesia 34.36 11.27 119 93263 276402 110219515
Toxic epidermal necrolysis 33.98 11.27 4 93378 56723 110439194
Supraventricular tachycardia 33.77 11.27 68 93314 24354 110471563
Product use in unapproved indication 33.26 11.27 231 93151 447146 110048771
Neuromuscular blockade 33.22 11.27 15 93367 729 110495188
Catheter site swelling 33.14 11.27 22 93360 2302 110493615
Complication associated with device 32.81 11.27 60 93322 20013 110475904
Pneumonia bacterial 32.66 11.27 70 93312 26191 110469726
Condition aggravated 32.48 11.27 831 92551 734005 109761912
Catheter site scab 32.32 11.27 11 93371 248 110495669
Nocturnal dyspnoea 32.31 11.27 20 93362 1855 110494062
Seasonal allergy 32.29 11.27 59 93323 19663 110476254
Device infusion issue 32.18 11.27 24 93358 3021 110492896
Hepatitis 32.12 11.27 18 93364 90036 110405881
Loss of consciousness 32.10 11.27 279 93103 196027 110299890
Rales 31.99 11.27 67 93315 24672 110471245
Abdominal distension 31.90 11.27 255 93127 174848 110321069
Catheter removal 31.85 11.27 14 93368 638 110495279
Pulmonary artery dilatation 31.69 11.27 14 93368 646 110495271
Knee arthroplasty 31.45 11.27 8 93374 64940 110430977
Maternal exposure during pregnancy 31.45 11.27 110 93272 254773 110241144
Central venous catheterisation 31.36 11.27 26 93356 3816 110492101
Respiratory syncytial virus infection 31.25 11.27 49 93333 14435 110481482
Sciatica 30.82 11.27 20 93362 92379 110403538
Cardiac pacemaker insertion 30.74 11.27 32 93350 6269 110489648
Concomitant disease progression 30.66 11.27 25 93357 3585 110492332
Right ventricular dysfunction 30.32 11.27 24 93358 3299 110492618
Bronchospasm 30.29 11.27 74 93308 30165 110465752
Pulmonary alveolar haemorrhage 30.15 11.27 58 93324 20092 110475825
Coma 30.12 11.27 33 93349 117836 110378081
Acute right ventricular failure 29.94 11.27 12 93370 433 110495484
Procedural complication 29.56 11.27 36 93346 8369 110487548
Paracentesis 29.50 11.27 17 93365 1383 110494534
Accident 29.31 11.27 41 93341 10911 110485006
Delayed recovery from anaesthesia 29.26 11.27 20 93362 2195 110493722
Apnoea 29.23 11.27 46 93336 13593 110482324
Malaise 29.17 11.27 758 92624 671061 109824856
Prescribed overdose 29.15 11.27 19 93363 87562 110408355
Suicidal ideation 29.12 11.27 22 93360 93915 110402002
Abdominal pain 28.98 11.27 285 93097 512704 109983213
Sputum discoloured 28.64 11.27 69 93313 27876 110468041
Aspiration pleural cavity 28.60 11.27 18 93364 1719 110494198
Gamma-glutamyltransferase increased 28.58 11.27 115 93267 61194 110434723
Pulmonary capillary haemangiomatosis 28.26 11.27 8 93374 95 110495822
Autoimmune disorder 28.20 11.27 10 93372 65473 110430444
Congestive hepatopathy 28.18 11.27 28 93354 5192 110490725
Exostosis 28.13 11.27 3 93379 45953 110449964
Cardiac ablation 28.04 11.27 21 93361 2661 110493256
Epilepsy 27.95 11.27 26 93356 100183 110395734
Neoplasm progression 27.59 11.27 10 93372 64585 110431332
Bradycardia 27.52 11.27 225 93157 155292 110340625
Pulmonary function test abnormal 27.32 11.27 27 93355 4973 110490944
COVID-19 pneumonia 27.23 11.27 81 93301 37062 110458855
Hypoaesthesia 27.08 11.27 155 93227 314068 110181849
Gastrointestinal disorder 26.87 11.27 109 93273 241843 110254074
Prescribed underdose 26.33 11.27 11 93371 65163 110430754
Leukopenia 26.07 11.27 54 93328 148737 110347180
Gait inability 26.06 11.27 47 93335 136329 110359588
Catheter site warmth 26.00 11.27 10 93372 323 110495594
Coeliac disease 25.98 11.27 3 93379 43184 110452733
Catheter site inflammation 25.98 11.27 15 93367 1225 110494692
Rhonchi 25.82 11.27 25 93357 4493 110491424
Injection site erythema 25.61 11.27 25 93357 94151 110401766
Tracheostomy 25.59 11.27 16 93366 1511 110494406
Onychomadesis 25.50 11.27 4 93378 45659 110450258
Blood alkaline phosphatase increased 25.42 11.27 123 93259 70812 110425105
Mediastinal effusion 25.38 11.27 7 93375 75 110495842
Malignant neoplasm progression 25.31 11.27 70 93312 174497 110321420
Acute postoperative sialadenitis 25.30 11.27 7 93375 76 110495841
Exposure during pregnancy 25.13 11.27 66 93316 167358 110328559
Ventricular tachycardia 25.09 11.27 96 93286 49913 110446004
Haemodynamic instability 25.07 11.27 58 93324 22830 110473087
Device leakage 25.01 11.27 47 93335 16001 110479916
Oxygen consumption 24.66 11.27 7 93375 84 110495833
Haemoglobin decreased 24.42 11.27 319 93063 248408 110247509
Oedematous kidney 24.31 11.27 9 93373 261 110495656
Stevens-Johnson syndrome 24.26 11.27 5 93377 46896 110449021
Rhinorrhoea 24.16 11.27 159 93223 102507 110393410
Cognitive disorder 24.06 11.27 23 93359 87488 110408429
Agranulocytosis 24.04 11.27 11 93371 61749 110434168
Blood potassium decreased 24.03 11.27 100 93282 54014 110441903
Lung adenocarcinoma stage IV 23.88 11.27 11 93371 560 110495357
Tubulointerstitial nephritis 23.88 11.27 8 93374 54276 110441641
Swelling 23.80 11.27 186 93196 350855 110145062
Bronchopulmonary aspergillosis 23.70 11.27 67 93315 29796 110466121
Drug resistance 23.62 11.27 9 93373 56365 110439552
Infusion site haemorrhage 23.60 11.27 24 93358 4574 110491343
Aspartate aminotransferase increased 23.43 11.27 222 93160 159714 110336203
Foot deformity 23.42 11.27 6 93376 48474 110447443
Anaemia 23.35 11.27 616 92766 546470 109949447
Disseminated strongyloidiasis 23.21 11.27 11 93371 598 110495319
Osteonecrosis of jaw 23.09 11.27 6 93376 48011 110447906
Neutrophil count decreased 22.83 11.27 42 93340 120899 110375018
Hepatic cytolysis 22.72 11.27 9 93373 55044 110440873
Colitis 22.63 11.27 32 93350 102291 110393626
Onychomycosis 22.39 11.27 3 93379 38528 110457389
Lung infiltration 22.29 11.27 58 93324 24570 110471347
Taste disorder 22.01 11.27 14 93368 65373 110430544
Musculoskeletal pain 21.90 11.27 80 93302 182943 110312974
Angioplasty 21.88 11.27 16 93366 1955 110493962
Infusion site discharge 21.86 11.27 16 93366 1957 110493960
Sepsis 21.79 11.27 393 92989 326953 110168964
General physical health deterioration 21.67 11.27 242 93140 425053 110070864
Dry mouth 21.63 11.27 91 93291 199857 110296060
Pulmonary trichosporonosis 21.61 11.27 6 93376 66 110495851
Intentional self-injury 21.55 11.27 3 93379 37426 110458491
Mouth ulceration 21.34 11.27 7 93375 48131 110447786
Hyperthermia malignant 21.20 11.27 21 93361 3879 110492038
Multiple sclerosis relapse 21.08 11.27 8 93374 50232 110445685
Localised oedema 21.01 11.27 32 93350 9191 110486726
Rash maculo-papular 21.01 11.27 19 93363 74203 110421714
Weight decreased 20.84 11.27 530 92852 467527 110028390
Decreased activity 20.78 11.27 35 93347 10939 110484978
Platelet transfusion 20.65 11.27 18 93364 2828 110493089
Increased ventricular preload 20.55 11.27 5 93377 31 110495886
Adverse drug reaction 20.51 11.27 36 93346 105523 110390394
Cold burn 20.27 11.27 4 93378 7 110495910
Mechanical ventilation 20.23 11.27 19 93363 3288 110492629
Thrombocytopenia 20.03 11.27 193 93189 348692 110147225
Pregnancy 20.03 11.27 9 93373 51058 110444859
Right ventricular systolic pressure increased 19.95 11.27 12 93370 1057 110494860
Liver disorder 19.91 11.27 58 93324 142185 110353732
Hypoglycaemia 19.62 11.27 43 93339 116061 110379856
Iron deficiency anaemia 19.61 11.27 65 93317 31494 110464423
Catheter site granuloma 19.55 11.27 6 93376 96 110495821
Dizziness postural 19.40 11.27 40 93342 14569 110481348
Product use issue 19.38 11.27 169 93213 311526 110184391
Vascular device infection 19.38 11.27 43 93339 16469 110479448
Pulmonary artery banding 19.31 11.27 4 93378 10 110495907
Right-to-left cardiac shunt 19.26 11.27 8 93374 317 110495600
Cytomegalovirus infection 19.25 11.27 11 93371 54433 110441484
PaO2/FiO2 ratio decreased 19.22 11.27 5 93377 42 110495875
Upper respiratory tract inflammation 19.20 11.27 21 93361 4350 110491567
Anaesthetic complication cardiac 19.16 11.27 6 93376 103 110495814
Haematocrit decreased 19.11 11.27 108 93274 66009 110429908
Abdominal cavity drainage 19.03 11.27 11 93371 900 110495017
Choking sensation 18.95 11.27 21 93361 4415 110491502
Road traffic accident 18.79 11.27 39 93343 107359 110388558
Angioedema 18.77 11.27 34 93348 98466 110397451
Bone marrow failure 18.65 11.27 13 93369 57835 110438082
Throat irritation 18.58 11.27 92 93290 53460 110442457
Blood immunoglobulin E 18.53 11.27 5 93377 49 110495868
Myelosuppression 18.49 11.27 32 93350 94308 110401609
Injection site swelling 18.49 11.27 15 93367 61775 110434142
Nightmare 18.41 11.27 5 93377 38858 110457059
Arthritis 18.29 11.27 76 93306 167510 110328407
Dermatitis contact 18.28 11.27 38 93344 13915 110482002
Finger deformity 18.25 11.27 3 93379 33089 110462828
Overdose 18.21 11.27 119 93263 233675 110262242
Urine output decreased 18.19 11.27 47 93335 19829 110476088
Retching 18.11 11.27 51 93331 22631 110473286
Pancreatitis 18.08 11.27 32 93350 93501 110402416
Injection site pain 18.01 11.27 83 93299 177839 110318078
Illness 17.98 11.27 125 93257 82046 110413871
Terminal state 17.90 11.27 23 93359 5644 110490273
Paradoxical embolism 17.85 11.27 5 93377 57 110495860
Cardiorenal syndrome 17.82 11.27 14 93368 1904 110494013
Jugular vein distension 17.67 11.27 13 93369 1603 110494314
Swollen tongue 17.63 11.27 15 93367 60347 110435570
Osteoporosis 17.60 11.27 29 93353 87123 110408794
Exercise test abnormal 17.54 11.27 5 93377 61 110495856
Middle ear effusion 17.45 11.27 16 93366 2685 110493232
Tricuspid valve incompetence 17.44 11.27 52 93330 23821 110472096
Hip arthroplasty 17.39 11.27 13 93369 55800 110440117
Alkalosis hypochloraemic 17.39 11.27 9 93373 592 110495325
Ascites 17.36 11.27 136 93246 92672 110403245
Hyponatraemia 17.35 11.27 110 93272 217543 110278374
Catheter site vesicles 17.27 11.27 8 93374 413 110495504
Uterine hypotonus 17.24 11.27 6 93376 145 110495772
SARS-CoV-2 viraemia 17.16 11.27 6 93376 147 110495770
Right ventricular dilatation 17.12 11.27 15 93367 2372 110493545
Limb injury 17.06 11.27 70 93312 37566 110458351
Amnesia 17.03 11.27 40 93342 105368 110390549
Aggression 16.95 11.27 15 93367 59195 110436722
Chills 16.89 11.27 240 93142 190340 110305577
Tachycardia 16.84 11.27 277 93105 226368 110269549
Glossoptosis 16.83 11.27 7 93375 278 110495639
Lung assist device therapy 16.82 11.27 6 93376 156 110495761
White blood cell count decreased 16.75 11.27 119 93263 229271 110266646
Catheter site irritation 16.72 11.27 9 93373 641 110495276
Argon plasma coagulation 16.69 11.27 4 93378 23 110495894
Emergency care 16.59 11.27 12 93370 1441 110494476
Procedural hypotension 16.50 11.27 15 93367 2490 110493427
Malassezia infection 16.47 11.27 5 93377 77 110495840
Infusion site irritation 16.46 11.27 11 93371 1164 110494753
Acute pulmonary oedema 16.39 11.27 41 93341 16955 110478962
Hospice care 16.38 11.27 34 93348 12439 110483478
Rehabilitation therapy 16.35 11.27 14 93368 2147 110493770
Rotavirus infection 16.26 11.27 10 93372 917 110495000
Ventricular extrasystoles 16.24 11.27 49 93333 22592 110473325
Sedation 16.21 11.27 21 93361 69662 110426255
Device malfunction 16.21 11.27 53 93329 25505 110470412
Cardiac failure high output 15.81 11.27 8 93374 502 110495415
Head injury 15.71 11.27 75 93307 42942 110452975
Neuropathy peripheral 15.67 11.27 88 93294 179189 110316728
Atelectasis 15.65 11.27 67 93315 36645 110459272
Liver function test increased 15.62 11.27 32 93350 88516 110407401
Myotonic dystrophy 15.62 11.27 6 93376 193 110495724
Brain hypoxia 15.59 11.27 11 93371 1271 110494646
Cardioversion 15.48 11.27 14 93368 2309 110493608
Medication error 15.46 11.27 42 93340 105324 110390593
Corynebacterium bacteraemia 15.42 11.27 6 93376 200 110495717
Pancreatitis haemorrhagic 15.42 11.27 10 93372 1006 110494911
Right ventricular enlargement 15.37 11.27 10 93372 1011 110494906
Rhinovirus infection 15.32 11.27 32 93350 11757 110484160
Muscular weakness 15.31 11.27 135 93247 248333 110247584
Thyroglobulin increased 15.30 11.27 5 93377 99 110495818
Lower limb fracture 15.28 11.27 25 93357 75323 110420594
Poisoning 15.27 11.27 3 93379 29102 110466815
Mucormycosis 15.18 11.27 30 93352 10598 110485319
Catheter site hypersensitivity 15.16 11.27 5 93377 102 110495815
Blood iron decreased 15.14 11.27 43 93339 19171 110476746
Stress cardiomyopathy 15.11 11.27 38 93344 15768 110480149
Joint dislocation 15.11 11.27 5 93377 34185 110461732
Bifidobacterium infection 15.07 11.27 5 93377 104 110495813
Eosinophilia 15.05 11.27 16 93366 57920 110437997
Pulmonary thrombosis 15.04 11.27 35 93347 13828 110482089
Catheter site dermatitis 15.02 11.27 5 93377 105 110495812
Stent placement 14.95 11.27 24 93358 7210 110488707
Inappropriate antidiuretic hormone secretion 14.87 11.27 5 93377 33846 110462071
Diarrhoea 14.82 11.27 1135 92247 1138370 109357547
Right ventricular hypertrophy 14.80 11.27 12 93370 1707 110494210
Blood urea increased 14.73 11.27 88 93294 54869 110441048
Cerebral haemorrhage 14.69 11.27 20 93362 64948 110430969
Infusion site abscess 14.68 11.27 7 93375 386 110495531
Alanine aminotransferase increased 14.55 11.27 227 93155 183546 110312371
Haemoglobin increased 14.52 11.27 27 93355 9120 110486797
Multiple allergies 14.46 11.27 32 93350 12231 110483686
Psychotic disorder 14.46 11.27 13 93369 50924 110444993
Cholestasis 14.44 11.27 20 93362 64498 110431419
Craniotomy 14.41 11.27 8 93374 606 110495311
Hypophosphataemia 14.41 11.27 5 93377 33177 110462740
Therapy non-responder 14.30 11.27 199 93183 157108 110338809
Proteinuria 14.27 11.27 8 93374 40010 110455907
Infusion site swelling 14.25 11.27 28 93354 9849 110486068
Acute respiratory distress syndrome 14.14 11.27 85 93297 53113 110442804
Respiratory rate increased 14.13 11.27 50 93332 25033 110470884
Airway burns 14.08 11.27 3 93379 9 110495908
Pulmonary nocardiosis 14.00 11.27 14 93368 2615 110493302
Cardiac assistance device user 13.98 11.27 5 93377 131 110495786
Rectal haemorrhage 13.93 11.27 53 93329 119780 110376137
Therapy partial responder 13.82 11.27 7 93375 37054 110458863
Therapy interrupted 13.81 11.27 13 93369 49809 110446108
Chapped lips 13.69 11.27 15 93367 3113 110492804
Peripheral swelling 13.67 11.27 442 92940 403592 110092325
Bronchopulmonary dysplasia 13.64 11.27 6 93376 274 110495643
Device dislocation 13.62 11.27 58 93324 31646 110464271
Basal cell carcinoma 13.53 11.27 11 93371 45259 110450658
Disease progression 13.52 11.27 285 93097 243749 110252168
Frostbite 13.52 11.27 6 93376 280 110495637
Gastrointestinal arteriovenous malformation 13.43 11.27 9 93373 956 110494961
Drug-induced liver injury 13.38 11.27 54 93328 120013 110375904
Systemic scleroderma 13.37 11.27 12 93370 1960 110493957
Vena cava filter insertion 13.35 11.27 5 93377 150 110495767
Electrocardiogram ST segment elevation 13.26 11.27 26 93356 9134 110486783
Chronic left ventricular failure 13.22 11.27 10 93372 1286 110494631
Respiration abnormal 13.19 11.27 27 93355 9782 110486135
Device issue 13.19 11.27 61 93321 34474 110461443
Pulmonary vein stenosis 13.10 11.27 5 93377 158 110495759
Muscle spasticity 13.07 11.27 7 93375 35908 110460009
Mastitis bacterial 13.03 11.27 4 93378 64 110495853
Respiratory disorder 13.01 11.27 104 93278 71278 110424639
Right atrial dilatation 12.98 11.27 9 93373 1011 110494906
Myositis 12.98 11.27 5 93377 31111 110464806
Gastrointestinal haemorrhage 12.93 11.27 204 93178 165314 110330603
Therapy change 12.84 11.27 27 93355 9970 110485947
Puncture site infection 12.81 11.27 4 93378 68 110495849
Agonal respiration 12.80 11.27 6 93376 318 110495599
Acute kidney injury 12.80 11.27 424 92958 635006 109860911
Oxygen saturation increased 12.75 11.27 8 93374 760 110495157
Abdominal discomfort 12.74 11.27 245 93137 393613 110102304
Dialysis 12.72 11.27 41 93341 19578 110476339
Haemorrhage 12.72 11.27 142 93240 106550 110389367
Gastrointestinal tube insertion 12.71 11.27 12 93370 2089 110493828
Cerebral infarction 12.71 11.27 15 93367 51823 110444094
Catheter site erosion 12.70 11.27 4 93378 70 110495847
Dysbiosis 12.56 11.27 12 93370 2120 110493797
Right ventricular systolic pressure 12.56 11.27 3 93379 17 110495900
Sinus congestion 12.53 11.27 55 93327 30404 110465513
Back injury 12.41 11.27 13 93369 47386 110448531
Injection site pruritus 12.39 11.27 15 93367 51243 110444674
Pulmonary toxicity 12.35 11.27 38 93344 17708 110478209
Thoracic cavity drainage 12.31 11.27 6 93376 347 110495570
Rhabdomyolysis 12.28 11.27 56 93326 120345 110375572
Blood carbon monoxide increased 12.27 11.27 3 93379 19 110495898
Impaired quality of life 12.23 11.27 5 93377 30012 110465905
Progressive multifocal leukoencephalopathy 12.23 11.27 3 93379 24953 110470964
Drug tolerance decreased 12.22 11.27 4 93378 27536 110468381
Disturbance in attention 12.17 11.27 21 93361 61974 110433943
Choking 12.09 11.27 34 93348 15076 110480841
Lung squamous cell carcinoma stage I 12.01 11.27 3 93379 21 110495896
Cardiac septal defect repair 12.01 11.27 3 93379 21 110495896
Pseudomonas infection 12.00 11.27 51 93331 27802 110468115
Influenza 11.95 11.27 205 93177 168896 110327021
PO2 decreased 11.92 11.27 14 93368 3134 110492783
Mineral supplementation 11.88 11.27 8 93374 857 110495060
Vascular cauterisation 11.84 11.27 4 93378 88 110495829
Laryngitis 11.83 11.27 11 93371 42400 110453517
Pulmonary pain 11.82 11.27 20 93362 6273 110489644
Sputum increased 11.78 11.27 19 93363 5732 110490185
Cardiac flutter 11.76 11.27 19 93363 5738 110490179
Candida infection 11.69 11.27 75 93307 47934 110447983
Nasal operation 11.66 11.27 6 93376 390 110495527
Haematoma evacuation 11.66 11.27 6 93376 390 110495527
Bronchopleural fistula 11.65 11.27 8 93374 885 110495032
Vasculitis 11.64 11.27 8 93374 35865 110460052
Rash pruritic 11.64 11.27 43 93339 98026 110397891
Superinfection fungal 11.64 11.27 4 93378 93 110495824
Diabetic ketoacidosis 11.63 11.27 11 93371 42047 110453870
Oxygen saturation 11.56 11.27 6 93376 397 110495520
Infusion site vesicles 11.52 11.27 7 93375 628 110495289
Vasodilatation 11.52 11.27 15 93367 3729 110492188
Infection 11.50 11.27 226 93156 361974 110133943
Cervix enlargement 11.45 11.27 3 93379 26 110495891
PCO2 increased 11.41 11.27 11 93371 1966 110493951
Blood bilirubin increased 11.39 11.27 106 93276 75866 110420051
Sinusitis 11.38 11.27 179 93203 296509 110199408
Stress 11.35 11.27 48 93334 105300 110390617
Breath sounds abnormal 11.32 11.27 47 93335 25357 110470560
Tracheal injury 11.29 11.27 5 93377 232 110495685

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AN01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:33893 reagent
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:63248 oxidizer
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:33937 macronutrients

Related Drugs by ATC class:

V03AN Medical gases 3 drugs
carbon dioxideheliumnitrogen

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
None (Med Gas) Air Liquide Industrial U.S. L.P. 2
None (Med Gas) Air Liquide Large Industries U.S. L.P. 2
None (Med Gas) Messer LLC 2
None (Med Gas) Messer Canada Inc. 2
None (Med Gas) Messer Gas Puerto Rico Inc. 2
None (Med Gas) Norco Inc. 2
None (Med Gas) Airgas Merchant Gases LLC 2
None (Med Gas) Praxair Inc. 2
None (Med Gas) Aspen Air, US Corp 2
None (Med Gas) Air Products and Chemicals Inc. 2
None (Med Gas) Air Liquide America L.P. 2
None (Med Gas) Matheson Tri-Gas Inc. 2
None (Med Gas) Praxair Canada Inc. 2
None (Med Gas) Airgas USA LLC 2
None (Med Gas) Praxair Mexico, S. de R.L. de C.V. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
S88TT14065 UNII
4019105 VUID
N0000147362 NUI
D00003 KEGG_DRUG
4019105 VANDF
C0184633 UMLSCUI
CHEBI:15379 CHEBI
WEQ PDB_CHEM_ID
CHEMBL1234886 ChEMBL_ID
977 PUBCHEM_CID
DB09140 DRUGBANK_ID
D010100 MESH_DESCRIPTOR_UI
7806 RXNORM
d06860 MMSL
000826 NDDF
24099007 SNOMEDCT_US
767111007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10014-001 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10014-001 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen Helium Mixture HUMAN PRESCRIPTION DRUG LABEL 2 10014-006 GAS 200 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Oxygen Helium Mixture 40/60 HUMAN PRESCRIPTION DRUG LABEL 2 10014-007 GAS 400 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Oxygen Helium Mixture HUMAN PRESCRIPTION DRUG LABEL 1 10014-009 GAS 200 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen Helium Mixture 30/70 HUMAN PRESCRIPTION DRUG LABEL 1 10014-018 GAS 300 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10018-8999 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10073-111 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10109-1234 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10163-0202 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-100 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
AIR COMPRESSED HUMAN PRESCRIPTION DRUG LABEL 1 10167-600 GAS 20 L RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10189-001 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-001 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-001 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10297-001 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Heliox HUMAN PRESCRIPTION DRUG LABEL 1 10297-080 GAS 200 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10297-100 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Air HUMAN PRESCRIPTION DRUG LABEL 1 10297-103 GAS 210 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10304-463 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10358-1417 GAS 995 mL NASAL unapproved medical gas 1 sections
OXYGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0001 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10451-001 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Air HUMAN PRESCRIPTION DRUG LABEL 1 10451-004 GAS 210 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10453-0123 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10482-001 GAS 995 L RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10492-001 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10526-001 GAS 990 L RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10526-005 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Oxygen HUMAN PRESCRIPTION DRUG LABEL 1 10641-001 GAS 995 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections