nitrogen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4251 7727-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrogen
  • molecular nitrogen
  • nitrogen gas
  • nitrogen, nf
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
  • Molecular weight: 28.01
  • Formula: N2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 47.58
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 939.53 11.76 1917 54481 590660 55645009
Pulmonary arterial hypertension 674.91 11.76 386 56012 26117 56209552
Oxygen saturation decreased 606.70 11.76 555 55843 78512 56157157
Pulmonary hypertension 519.66 11.76 366 56032 35578 56200091
Oxygen consumption increased 468.27 11.76 165 56233 3466 56232203
Right ventricular failure 445.06 11.76 249 56149 16130 56219539
Dyspnoea exertional 400.05 11.76 374 56024 54315 56181354
Fluid retention 386.31 11.76 365 56033 53713 56181956
Drug ineffective 351.47 11.76 248 56150 918741 55316928
Chronic obstructive pulmonary disease 325.90 11.76 342 56056 57073 56178596
Hypoxia 316.59 11.76 327 56071 53570 56182099
Rheumatoid arthritis 275.47 11.76 31 56367 382573 55853096
Respiratory failure 272.98 11.76 402 55996 94660 56141009
Hypervolaemia 218.90 11.76 194 56204 26264 56209405
Oxygen therapy 216.36 11.76 79 56319 1844 56233825
Pneumonia 206.57 11.76 880 55518 406218 55829451
Transfusion 205.36 11.76 142 56256 13378 56222291
Pain in jaw 174.70 11.76 208 56190 39828 56195841
Nasal congestion 166.92 11.76 242 56156 56128 56179541
Oedema peripheral 160.06 11.76 454 55944 170800 56064869
Acute respiratory failure 153.66 11.76 172 56226 30822 56204847
Arthropathy 141.99 11.76 17 56381 200258 56035411
Treatment failure 141.59 11.76 7 56391 170385 56065284
Cardiac failure 139.51 11.76 275 56123 81818 56153851
Alopecia 139.14 11.76 60 56338 293398 55942271
Cough 136.17 11.76 568 55830 259393 55976276
Productive cough 129.51 11.76 215 56183 56017 56179652
Glossodynia 127.51 11.76 6 56392 152452 56083217
Therapeutic product effect decreased 126.20 11.76 12 56386 169440 56066229
Drug intolerance 124.16 11.76 55 56343 264763 55970906
Chest pain 117.32 11.76 437 55961 189360 56046309
Pulmonary oedema 117.04 11.76 195 56203 50948 56184721
Joint swelling 116.98 11.76 73 56325 289727 55945942
Hand deformity 116.83 11.76 4 56394 134488 56101181
Pulmonary arterial pressure increased 115.47 11.76 60 56338 3345 56232324
Rash 111.21 11.76 203 56195 492844 55742825
Toxicity to various agents 111.12 11.76 43 56355 224521 56011148
Oedema 110.78 11.76 250 56148 81670 56153999
Concomitant disease aggravated 110.65 11.76 81 56317 8345 56227324
Systemic lupus erythematosus 110.26 11.76 23 56375 180055 56055614
Drug hypersensitivity 108.77 11.76 71 56327 275134 55960535
Epistaxis 94.50 11.76 208 56190 66815 56168854
Catheter site erythema 92.20 11.76 55 56343 4015 56231654
Catheter site pruritus 90.62 11.76 43 56355 1969 56233700
Haemoptysis 84.43 11.76 118 56280 26442 56209227
Syncope 84.12 11.76 269 56129 107930 56127739
Lung transplant 83.28 11.76 46 56352 2901 56232768
Musculoskeletal stiffness 80.30 11.76 28 56370 155979 56079690
Hypercapnia 78.49 11.76 54 56344 5042 56230627
Blood pressure decreased 77.36 11.76 178 56220 58872 56176797
Catheter management 76.83 11.76 43 56355 2783 56232886
Discomfort 75.48 11.76 24 56374 141737 56093932
Headache 75.44 11.76 873 55525 558171 55677498
Brain natriuretic peptide increased 74.97 11.76 51 56347 4675 56230994
Hepatic enzyme increased 73.58 11.76 40 56358 171344 56064325
Pericarditis 72.97 11.76 11 56387 108912 56126757
Cardiac failure congestive 72.69 11.76 223 56175 87497 56148172
Dependence on oxygen therapy 72.44 11.76 23 56375 345 56235324
Scleroderma 72.37 11.76 51 56347 4950 56230719
Arthralgia 70.44 11.76 262 56136 501407 55734262
Hypersensitivity 66.63 11.76 96 56302 256312 55979357
Wound 66.30 11.76 28 56370 138776 56096893
Hypotension 65.85 11.76 453 55945 250055 55985614
Off label use 65.40 11.76 311 56087 555869 55679800
Infusion related reaction 62.82 11.76 70 56328 208861 56026808
Catheterisation cardiac 62.80 11.76 44 56354 4231 56231438
Psoriatic arthropathy 61.57 11.76 3 56395 74005 56161664
Maternal exposure during pregnancy 60.93 11.76 60 56338 189493 56046176
Stomatitis 59.93 11.76 23 56375 120787 56114882
Device alarm issue 59.84 11.76 29 56369 1392 56234277
Pain 59.04 11.76 406 55992 662778 55572891
Product use issue 58.52 11.76 60 56338 185981 56049688
Pleural effusion 57.96 11.76 203 56195 85277 56150392
Palpitations 57.77 11.76 225 56173 99447 56136222
Neutropenia 56.93 11.76 45 56353 158122 56077547
Drug abuse 55.42 11.76 3 56395 67607 56168062
Dizziness 55.41 11.76 598 55800 375542 55860127
Death 55.10 11.76 553 55845 340873 55894796
Pulmonary veno-occlusive disease 54.97 11.76 25 56373 1038 56234631
Cyanosis 54.41 11.76 73 56325 15737 56219932
Cor pulmonale 53.46 11.76 30 56368 1951 56233718
Unevaluable event 53.07 11.76 135 56263 47552 56188117
Pericardial effusion 52.24 11.76 96 56302 27079 56208590
Flushing 51.49 11.76 171 56227 69929 56165740
Catheter site pain 51.30 11.76 39 56359 4254 56231415
Malaise 47.91 11.76 571 55827 367289 55868380
Device related infection 46.82 11.76 81 56317 21799 56213870
Catheter site discharge 46.72 11.76 27 56371 1858 56233811
Therapeutic product effect incomplete 46.59 11.76 24 56374 106007 56129662
Pruritus 45.90 11.76 163 56235 316460 55919209
Blister 45.87 11.76 26 56372 108861 56126808
Psoriasis 45.38 11.76 18 56380 92674 56142995
Catheter site infection 45.30 11.76 37 56361 4477 56231192
Exercise tolerance decreased 45.13 11.76 39 56359 5099 56230570
Chest discomfort 44.74 11.76 207 56191 98650 56137019
Dyspnoea at rest 44.15 11.76 34 56364 3779 56231890
Impaired healing 43.96 11.76 16 56382 86825 56148844
Chronic respiratory failure 43.25 11.76 25 56373 1721 56233948
Injection site erythema 43.23 11.76 12 56386 77436 56158233
Intentional overdose 43.13 11.76 8 56390 68109 56167560
Orthopnoea 42.89 11.76 40 56358 5776 56229893
Transplant evaluation 42.37 11.76 21 56377 1059 56234610
Respiratory distress 42.05 11.76 96 56302 31571 56204098
Bronchitis 41.48 11.76 222 56176 112089 56123580
Irritable bowel syndrome 41.34 11.76 9 56389 68449 56167220
Injection site pain 41.28 11.76 34 56364 117084 56118585
Suicide attempt 40.72 11.76 5 56393 57831 56177838
Left ventricular failure 40.04 11.76 36 56362 4960 56230709
Catheter site rash 39.63 11.76 18 56380 745 56234924
Exposure during pregnancy 39.53 11.76 47 56351 136295 56099374
Hospitalisation 39.21 11.76 164 56234 74836 56160833
Infusion site pain 39.13 11.76 58 56340 13704 56221965
Blood cholesterol increased 39.13 11.76 12 56386 72567 56163102
Lung disorder 38.35 11.76 128 56270 52469 56183200
Pulmonary arterial pressure abnormal 37.39 11.76 15 56383 455 56235214
Pulmonary hypertensive crisis 36.35 11.76 12 56386 205 56235464
Nasal dryness 35.70 11.76 30 56368 3776 56231893
Abdominal distension 35.45 11.76 163 56235 77463 56158206
Presyncope 34.46 11.76 78 56320 25504 56210165
Overdose 33.41 11.76 34 56364 105796 56129873
Urticaria 32.98 11.76 59 56339 144617 56091052
Aspiration pleural cavity 32.97 11.76 16 56382 770 56234899
Atrial flutter 32.57 11.76 43 56355 9126 56226543
Pulmonary congestion 32.33 11.76 58 56340 16057 56219612
Injection site reaction 32.15 11.76 7 56391 53240 56182429
Oxygen saturation abnormal 31.76 11.76 25 56373 2869 56232800
Bladder agenesis 31.74 11.76 10 56388 146 56235523
Ascites 31.59 11.76 96 56302 37448 56198221
Interstitial lung disease 31.58 11.76 127 56271 56936 56178733
Catheter placement 31.48 11.76 22 56376 2106 56233563
Air embolism 31.34 11.76 11 56387 228 56235441
Oxygen consumption 31.32 11.76 9 56389 94 56235575
Cloacal exstrophy 31.31 11.76 10 56388 153 56235516
Genitalia external ambiguous 31.31 11.76 10 56388 153 56235516
Emphysema 31.22 11.76 44 56354 9932 56225737
Cardiac disorder 31.11 11.76 109 56289 45778 56189891
Respiratory tract infection 31.07 11.76 93 56305 35978 56199691
Febrile neutropenia 31.00 11.76 36 56362 105509 56130160
Congenital ectopic bladder 30.98 11.76 9 56389 98 56235571
Cardiac arrest 30.77 11.76 169 56229 86145 56149524
Mobility decreased 29.90 11.76 33 56365 98958 56136711
Thermal burn 29.88 11.76 32 56366 5453 56230216
Cardiac pacemaker insertion 29.77 11.76 27 56371 3763 56231906
Condition aggravated 29.76 11.76 498 55900 344400 55891269
Meconium stain 29.40 11.76 10 56388 188 56235481
Subcutaneous emphysema 29.34 11.76 15 56383 808 56234861
Cardiac failure acute 29.06 11.76 40 56358 8833 56226836
Gastrointestinal disorder congenital 28.59 11.76 9 56389 131 56235538
Rales 28.43 11.76 44 56354 10796 56224873
Device occlusion 28.42 11.76 34 56364 6535 56229134
Anaemia 28.34 11.76 400 55998 267111 55968558
Central venous catheterisation 28.26 11.76 22 56376 2485 56233184
Swelling 28.10 11.76 134 56264 239637 55996032
Ill-defined disorder 27.96 11.76 17 56381 68526 56167143
Congenital genital malformation 27.92 11.76 9 56389 142 56235527
Tethered cord syndrome 27.73 11.76 10 56388 225 56235444
Gamma-glutamyltransferase increased 27.72 11.76 81 56317 30924 56204745
Device leakage 27.59 11.76 33 56365 6342 56229327
Paracentesis 27.57 11.76 15 56383 918 56234751
Lipodystrophy acquired 27.31 11.76 17 56381 1340 56234329
Cardiac ablation 27.19 11.76 17 56381 1350 56234319
Caudal regression syndrome 26.67 11.76 9 56389 165 56235504
Knee arthroplasty 26.35 11.76 6 56392 44253 56191416
Atrial fibrillation 26.25 11.76 193 56205 108704 56126965
Gastrointestinal malformation 26.13 11.76 9 56389 176 56235493
Leukopenia 25.74 11.76 20 56378 70920 56164749
Anaesthetic complication 25.66 11.76 18 56380 1734 56233935
Suicidal ideation 25.46 11.76 13 56385 57729 56177940
Abdominal discomfort 25.41 11.76 168 56230 277106 55958563
Intentional product use issue 25.22 11.76 38 56360 99695 56135974
Pulmonary function test decreased 25.15 11.76 24 56374 3567 56232102
Lower respiratory tract infection 25.11 11.76 48 56350 114746 56120923
Catheter site scab 25.02 11.76 9 56389 201 56235468
N-terminal prohormone brain natriuretic peptide increased 24.85 11.76 18 56380 1824 56233845
Blood iron decreased 24.76 11.76 45 56353 12582 56223087
Heart rate increased 24.49 11.76 155 56243 83118 56152551
Haemoglobin decreased 24.39 11.76 223 56175 133914 56101755
Liver injury 24.27 11.76 6 56392 41842 56193827
Product use in unapproved indication 23.50 11.76 68 56330 140754 56094915
Cognitive disorder 23.30 11.76 10 56388 49123 56186546
Anal atresia 22.79 11.76 10 56388 381 56235288
Depression 22.69 11.76 98 56300 180019 56055650
Rhinorrhoea 22.60 11.76 115 56283 56922 56178747
Anencephaly 22.56 11.76 9 56389 269 56235400
Walking distance test abnormal 22.48 11.76 11 56387 539 56235130
Injection site pruritus 22.48 11.76 7 56391 41924 56193745
Disease progression 22.35 11.76 181 56217 104992 56130677
Catheter site swelling 22.12 11.76 15 56383 1368 56234301
Haematocrit decreased 22.02 11.76 84 56314 36745 56198924
Sputum discoloured 22.01 11.76 46 56352 14246 56221423
Neuromuscular blockade 21.87 11.76 9 56389 292 56235377
Device connection issue 21.77 11.76 11 56387 578 56235091
Red blood cell sedimentation rate increased 21.74 11.76 5 56393 36618 56199051
Neural tube defect 21.70 11.76 8 56390 192 56235477
Congestive hepatopathy 21.51 11.76 19 56379 2557 56233112
Aspartate aminotransferase increased 21.41 11.76 149 56249 82453 56153216
Iron deficiency anaemia 21.27 11.76 52 56346 17867 56217802
Osteoarthritis 20.88 11.76 30 56368 80266 56155403
Concomitant disease progression 20.75 11.76 17 56381 2065 56233604
Nocturnal dyspnoea 20.72 11.76 13 56385 1039 56234630
Adverse drug reaction 20.46 11.76 21 56377 65111 56170558
Upper respiratory tract inflammation 20.15 11.76 18 56380 2459 56233210
Stent placement 19.84 11.76 21 56377 3530 56232139
Infusion site erythema 19.82 11.76 35 56363 9571 56226098
Cardiomegaly 19.77 11.76 48 56350 16419 56219250
Pneumothorax 19.66 11.76 45 56353 14822 56220847
Right ventricular dysfunction 19.58 11.76 15 56383 1654 56234015
Confusional state 19.12 11.76 126 56272 208029 56027640
Gastrointestinal disorder 19.11 11.76 54 56344 112648 56123021
Injection site swelling 18.93 11.76 10 56388 43568 56192101
Pulmonary artery banding 18.63 11.76 4 56394 10 56235659
Localised oedema 18.58 11.76 24 56374 4985 56230684
Multiple sclerosis relapse 18.50 11.76 11 56387 44892 56190777
Meningomyelocele 18.49 11.76 10 56388 605 56235064
Umbilical cord abnormality 18.47 11.76 10 56388 606 56235063
Sepsis neonatal 18.42 11.76 9 56389 440 56235229
Pulmonary alveolar haemorrhage 18.33 11.76 22 56376 4242 56231427
Uterine hypotonus 18.04 11.76 6 56392 105 56235564
C-reactive protein increased 18.00 11.76 32 56366 78652 56157017
Hyperandrogenism 17.94 11.76 6 56392 107 56235562
Malignant neoplasm progression 17.69 11.76 29 56369 73558 56162111
Hepatic function abnormal 17.61 11.76 75 56323 34483 56201186
Infusion site infection 17.55 11.76 14 56384 1638 56234031
Tachypnoea 17.49 11.76 44 56354 15386 56220283
Product dose omission issue 17.38 11.76 295 56103 204458 56031211
Mediastinal effusion 17.33 11.76 5 56393 53 56235616
Supraventricular tachycardia 17.32 11.76 40 56358 13251 56222418
Gout 17.29 11.76 38 56360 12183 56223486
Sepsis 17.23 11.76 215 56183 139625 56096044
Cardioversion 17.17 11.76 12 56386 1149 56234520
Osteonecrosis of jaw 17.12 11.76 6 56392 33352 56202317
Bronchospasm 17.05 11.76 44 56354 15625 56220044
Paraesthesia 17.05 11.76 70 56328 130444 56105225
Right ventricular systolic pressure increased 17.04 11.76 9 56389 519 56235150
Upper respiratory tract infection 16.98 11.76 126 56272 71162 56164507
Injury 16.94 11.76 21 56377 59830 56175839
Oxygen consumption decreased 16.92 11.76 7 56391 230 56235439
Coma 16.82 11.76 21 56377 59634 56176035
Exomphalos 16.64 11.76 9 56389 544 56235125
Ventilation perfusion mismatch 16.56 11.76 7 56391 243 56235426
Abdominal cavity drainage 16.47 11.76 8 56390 386 56235283
Argon plasma coagulation 16.32 11.76 4 56394 21 56235648
Feeling abnormal 16.28 11.76 205 56193 133397 56102272
Terminal state 16.25 11.76 15 56383 2138 56233531
Platelet transfusion 16.23 11.76 10 56388 774 56234895
Oedematous kidney 16.20 11.76 5 56393 68 56235601
Hospice care 16.09 11.76 25 56373 6155 56229514
Enlarged clitoris 16.04 11.76 6 56392 150 56235519
Pulmonary pain 16.04 11.76 17 56381 2863 56232806
Pulmonary artery dilatation 15.92 11.76 7 56391 268 56235401
Wheezing 15.87 11.76 129 56269 74897 56160772
Fibromyalgia 15.76 11.76 22 56376 59581 56176088
Pulmonary haemorrhage 15.69 11.76 26 56372 6757 56228912
Cold burn 15.64 11.76 3 56395 3 56235666
Acute postoperative sialadenitis 15.59 11.76 4 56394 26 56235643
Echocardiogram 15.46 11.76 4 56394 27 56235642
Accident 15.45 11.76 23 56375 5453 56230216
Jugular vein distension 15.25 11.76 10 56388 862 56234807
Tracheostomy 15.15 11.76 9 56389 652 56235017
Pulmonary capillary haemangiomatosis 15.10 11.76 4 56394 30 56235639
Rehabilitation therapy 15.09 11.76 12 56386 1398 56234271
Breath sounds abnormal 15.07 11.76 30 56368 8977 56226692
PO2 decreased 15.06 11.76 12 56386 1401 56234268
Lung assist device therapy 15.01 11.76 5 56393 88 56235581
Pneumonia bacterial 14.97 11.76 28 56370 8000 56227669
Procedural hypotension 14.94 11.76 11 56387 1143 56234526
Neuropathy peripheral 14.85 11.76 53 56345 102840 56132829
Rhonchi 14.85 11.76 15 56383 2389 56233280
Blood urea increased 14.78 11.76 56 56342 24417 56211252
Idiopathic pulmonary fibrosis 14.68 11.76 12 56386 1454 56234215
Bone marrow failure 14.67 11.76 5 56393 28281 56207388
Red blood cell count decreased 14.62 11.76 74 56324 36543 56199126
Systemic scleroderma 14.53 11.76 10 56388 934 56234735
Paradoxical embolism 14.45 11.76 4 56394 36 56235633
Tachycardia 14.45 11.76 166 56232 105710 56129959
Neoplasm progression 14.43 11.76 7 56391 32009 56203660
Carbon dioxide increased 14.42 11.76 11 56387 1206 56234463
Hypoglycaemia 14.36 11.76 21 56377 55794 56179875
Decreased appetite 14.19 11.76 303 56095 218928 56016741
Bursitis 14.09 11.76 5 56393 27577 56208092
Secretion discharge 14.03 11.76 32 56366 10514 56225155
Catheter site warmth 14.02 11.76 6 56392 215 56235454
COVID-19 pneumonia 14.02 11.76 33 56365 11069 56224600
Therapy change 14.01 11.76 22 56376 5466 56230203
Catheter site inflammation 13.98 11.76 9 56389 752 56234917
Catheter site hypersensitivity 13.88 11.76 5 56393 112 56235557
Hip arthroplasty 13.87 11.76 11 56387 38612 56197057
Middle ear effusion 13.87 11.76 14 56384 2228 56233441
Weight decreased 13.79 11.76 327 56071 240387 55995282
Injection site bruising 13.79 11.76 11 56387 38510 56197159
Blood pressure increased 13.77 11.76 87 56311 145089 56090580
Pregnancy 13.74 11.76 8 56390 33025 56202644
Type 2 diabetes mellitus 13.74 11.76 16 56382 46846 56188823
Dizziness exertional 13.73 11.76 7 56391 375 56235294
Increased bronchial secretion 13.72 11.76 12 56386 1595 56234074
Catheter site haemorrhage 13.68 11.76 16 56382 3002 56232667
Gastrointestinal arteriovenous malformation 13.68 11.76 8 56390 563 56235106
Biopsy liver 13.52 11.76 7 56391 387 56235282
Pneumomediastinum 13.52 11.76 11 56387 1324 56234345
Spina bifida 13.49 11.76 9 56389 799 56234870
Angioedema 13.44 11.76 13 56385 41440 56194229
Therapeutic response decreased 13.43 11.76 20 56378 52738 56182931
Mucosal inflammation 13.22 11.76 14 56384 42796 56192873
Colitis ulcerative 13.20 11.76 4 56394 24387 56211282
Apnoea 13.19 11.76 25 56373 7217 56228452
Rhabdomyolysis 12.89 11.76 13 56385 40645 56195024
Right ventricular dilatation 12.87 11.76 10 56388 1126 56234543
Urinary retention 12.86 11.76 6 56392 28068 56207601
Hepatitis 12.84 11.76 10 56388 35431 56200238
Hypertension 12.84 11.76 170 56228 244108 55991561
Choking 12.75 11.76 28 56370 8969 56226700
Therapy non-responder 12.71 11.76 105 56293 61250 56174419
Administration site pruritus 12.62 11.76 6 56392 276 56235393
Nasal discomfort 12.60 11.76 18 56380 4114 56231555
Neutrophil count decreased 12.57 11.76 19 56379 49803 56185866
Right ventricular hypertrophy 12.56 11.76 8 56390 656 56235013
Inflammation 12.53 11.76 32 56366 69039 56166630
Hypozincaemia 12.53 11.76 3 56395 14 56235655
Choking sensation 12.49 11.76 16 56382 3295 56232374
Vascular cauterisation 12.48 11.76 4 56394 62 56235607
Emergency care 12.47 11.76 9 56389 907 56234762
Polypectomy 12.45 11.76 8 56390 666 56235003
Dialysis 12.42 11.76 29 56369 9673 56225996
Cardiac failure high output 12.40 11.76 6 56392 287 56235382
Menstrual discomfort 12.36 11.76 3 56395 15 56235654
Lung squamous cell carcinoma stage I 12.36 11.76 3 56395 15 56235654
Decreased activity 12.34 11.76 21 56377 5575 56230094
Catheter site erosion 12.30 11.76 4 56394 65 56235604
Glossoptosis 12.25 11.76 4 56394 66 56235603
Acute right ventricular failure 12.18 11.76 5 56393 161 56235508
Oesophageal dilation procedure 12.08 11.76 4 56394 69 56235600
Brain hypoxia 12.07 11.76 7 56391 485 56235184
Rash maculo-papular 12.03 11.76 7 56391 28900 56206769
Chills 11.89 11.76 156 56242 102448 56133221
Abdominal pain 11.89 11.76 185 56213 258620 55977049
Stress cardiomyopathy 11.88 11.76 26 56372 8310 56227359

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 383.33 12.70 890 26836 342589 31327029
Oxygen saturation decreased 331.12 12.70 302 27424 48813 31620805
Pulmonary arterial hypertension 273.71 12.70 145 27581 9676 31659942
Hypoxia 225.56 12.70 248 27478 50065 31619553
Right ventricular failure 204.88 12.70 113 27613 8169 31661449
Chronic obstructive pulmonary disease 187.61 12.70 214 27512 44952 31624666
Oxygen consumption increased 171.16 12.70 58 27668 1244 31668374
Pulmonary hypertension 170.77 12.70 141 27585 19900 31649718
Respiratory failure 138.15 12.70 286 27440 101163 31568455
Fluid retention 117.55 12.70 126 27600 24676 31644942
Concomitant disease aggravated 114.87 12.70 66 27660 5158 31664460
Pneumonia 106.83 12.70 575 27151 334737 31334881
Acute respiratory failure 99.98 12.70 123 27603 27932 31641686
Dyspnoea exertional 82.67 12.70 133 27593 38704 31630914
Oxygen therapy 68.08 12.70 26 27700 794 31668824
Transfusion 65.55 12.70 54 27672 7586 31662032
Toxicity to various agents 63.87 12.70 40 27686 181447 31488171
Pain in jaw 62.92 12.70 65 27661 12190 31657428
Thermal burn 61.52 12.70 34 27692 2464 31667154
Hypervolaemia 60.19 12.70 77 27649 18174 31651444
Nasal congestion 56.50 12.70 79 27647 20302 31649316
Completed suicide 56.09 12.70 7 27719 91507 31578111
Respiratory distress 53.26 12.70 101 27625 33452 31636166
Cerebral artery thrombosis 52.10 12.70 21 27705 742 31668876
Drug abuse 50.76 12.70 8 27718 87750 31581868
Brain scan abnormal 49.72 12.70 21 27705 837 31668781
Pulmonary oedema 48.61 12.70 115 27611 44387 31625231
Idiopathic pulmonary fibrosis 48.11 12.70 35 27691 4095 31665523
Cough 48.03 12.70 239 27487 134575 31535043
Pulmonary arterial pressure increased 45.61 12.70 22 27704 1200 31668418
Brain natriuretic peptide increased 38.80 12.70 33 27693 4843 31664775
Hypercapnia 38.17 12.70 30 27696 3941 31665677
Condition aggravated 35.36 12.70 255 27471 163754 31505864
Oedema 35.12 12.70 99 27627 42462 31627156
Neutropenia 34.78 12.70 43 27683 140321 31529297
Pneumothorax 34.72 12.70 57 27669 16853 31652765
Lung transplant 34.24 12.70 21 27705 1849 31667769
Blood pressure decreased 34.11 12.70 106 27620 47985 31621633
Haemoptysis 33.86 12.70 82 27644 32107 31637511
Catheter site erythema 33.49 12.70 18 27708 1234 31668384
Areflexia 33.11 12.70 24 27702 2792 31666826
Catheter management 30.47 12.70 15 27711 856 31668762
Cor pulmonale 30.18 12.70 14 27712 699 31668919
Drug ineffective 29.99 12.70 213 27513 395360 31274258
Cardiac arrest 28.96 12.70 154 27572 88908 31580710
Rheumatoid arthritis 28.46 12.70 4 27722 47805 31621813
Emphysema 28.41 12.70 37 27689 8881 31660737
Cardiac failure 28.20 12.70 149 27577 85804 31583814
Oedema peripheral 27.34 12.70 177 27549 109662 31559956
Chronic respiratory failure 27.22 12.70 16 27710 1304 31668314
Lung disorder 26.50 12.70 75 27651 32237 31637381
Pulmonary function test abnormal 26.28 12.70 19 27707 2202 31667416
Neuromuscular block prolonged 25.73 12.70 11 27715 452 31669166
Cyanosis 24.69 12.70 40 27686 11695 31657923
Mechanical ventilation 24.37 12.70 17 27709 1862 31667756
Catheter removal 23.08 12.70 8 27718 184 31669434
Catheterisation cardiac 22.94 12.70 18 27708 2358 31667260
Catheter site haemorrhage 22.78 12.70 17 27709 2067 31667551
Accident 22.37 12.70 22 27704 3889 31665729
Pulmonary veno-occlusive disease 22.23 12.70 10 27716 465 31669153
Transplant evaluation 21.77 12.70 10 27716 488 31669130
Air embolism 21.40 12.70 7 27719 134 31669484
Intentional overdose 21.32 12.70 5 27721 41384 31628234
Catheter placement 21.27 12.70 11 27715 697 31668921
Subacute combined cord degeneration 20.97 12.70 7 27719 143 31669475
Rotavirus infection 20.60 12.70 9 27717 390 31669228
Hypotension 20.56 12.70 271 27455 204347 31465271
Catheter site pain 20.48 12.70 13 27713 1216 31668402
Pulmonary function test decreased 20.27 12.70 22 27704 4363 31665255
Carbon dioxide increased 20.09 12.70 12 27714 1007 31668611
Headache 20.04 12.70 247 27479 183405 31486213
Catheter site discharge 19.95 12.70 10 27716 593 31669025
Anaesthetic complication 19.93 12.70 12 27714 1022 31668596
Catheter site granuloma 19.72 12.70 5 27721 36 31669582
Pulmonary fibrosis 19.21 12.70 44 27682 16616 31653002
Interstitial lung disease 19.15 12.70 105 27621 61298 31608320
Hyperthermia malignant 19.09 12.70 15 27711 1969 31667649
Catheter site pruritus 19.06 12.70 8 27718 314 31669304
Bradycardia 18.65 12.70 114 27612 69213 31600405
Burns third degree 18.57 12.70 7 27719 206 31669412
Productive cough 18.53 12.70 68 27658 33472 31636146
Aggression 18.26 12.70 5 27721 37286 31632332
Suicide attempt 18.22 12.70 5 27721 37243 31632375
Burns second degree 18.11 12.70 8 27718 356 31669262
Catheter site warmth 18.00 12.70 5 27721 53 31669565
Hyponatraemia 17.85 12.70 23 27703 73776 31595842
Respiratory acidosis 17.50 12.70 21 27705 4641 31664977
Treatment failure 17.30 12.70 7 27719 40785 31628833
Cardiac failure congestive 16.81 12.70 123 27603 79264 31590354
Ventricular tachycardia 16.57 12.70 52 27674 23649 31645969
Hypocapnia 16.37 12.70 6 27720 163 31669455
Ventilation perfusion mismatch 16.23 12.70 5 27721 78 31669540
Pulmonary hypertensive crisis 16.23 12.70 6 27720 167 31669451
Therapeutic product effect incomplete 16.22 12.70 9 27717 43687 31625931
Epistaxis 16.18 12.70 91 27635 53616 31616002
Walking distance test abnormal 16.17 12.70 6 27720 169 31669449
Infusion site vesicles 16.13 12.70 6 27720 170 31669448
Accidental underdose 16.06 12.70 8 27718 468 31669150
Pulse pressure decreased 15.84 12.70 6 27720 179 31669439
Anaesthetic complication cardiac 15.76 12.70 4 27722 29 31669589
Thoracic cavity drainage 15.69 12.70 6 27720 184 31669434
Respiratory tract infection 15.62 12.70 42 27684 17519 31652099
Confusional state 15.51 12.70 62 27664 133272 31536346
Psoriasis 15.45 12.70 11 27715 46708 31622910
PaO2/FiO2 ratio decreased 15.30 12.70 4 27722 33 31669585
Tachypnoea 15.25 12.70 40 27686 16443 31653175
Acute kidney injury 15.18 12.70 164 27562 279550 31390068
Barotrauma 15.09 12.70 4 27722 35 31669583
Pulmonary capillary haemangiomatosis 15.09 12.70 4 27722 35 31669583
Dependence on oxygen therapy 15.05 12.70 6 27720 206 31669412
Catheter site inflammation 14.99 12.70 6 27720 208 31669410
Complication associated with device 14.97 12.70 21 27705 5408 31664210
White blood cell count decreased 14.93 12.70 34 27692 87364 31582254
Pulmonary congestion 14.65 12.70 34 27692 12949 31656669
Abdominal pain 14.48 12.70 72 27654 145880 31523738
Drug interaction 14.44 12.70 115 27611 208428 31461190
Acute right ventricular failure 14.26 12.70 5 27721 119 31669499
Hemiplegia 14.26 12.70 23 27703 6699 31662919
Pulseless electrical activity 14.24 12.70 23 27703 6704 31662914
Pulmonary alveolar haemorrhage 14.15 12.70 23 27703 6743 31662875
Apnoea 14.02 12.70 22 27704 6260 31663358
Pneumomediastinum 13.98 12.70 13 27713 2144 31667474
Thrombocytopenia 13.83 12.70 71 27655 142676 31526942
Syncope 13.71 12.70 124 27602 85058 31584560
Dyspnoea at rest 13.41 12.70 16 27710 3515 31666103
Aspartate aminotransferase increased 13.17 12.70 97 27629 62622 31606996
Leukopenia 13.00 12.70 19 27707 57809 31611809
Procedural complication 12.95 12.70 17 27709 4112 31665506
Rectal haemorrhage 12.74 12.70 8 27718 36296 31633322

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1064.81 11.38 2398 70719 767662 70087665
Pulmonary arterial hypertension 870.64 11.38 496 72621 32359 70822968
Oxygen saturation decreased 784.14 11.38 770 72347 115659 70739668
Pulmonary hypertension 599.74 11.38 447 72670 46089 70809238
Oxygen consumption increased 572.46 11.38 206 72911 4474 70850853
Right ventricular failure 554.54 11.38 323 72794 21951 70833376
Fluid retention 480.82 11.38 448 72669 62937 70792390
Hypoxia 456.47 11.38 521 72596 92823 70762504
Dyspnoea exertional 409.45 11.38 453 72664 77977 70777350
Chronic obstructive pulmonary disease 363.76 11.38 424 72693 77217 70778110
Respiratory failure 281.56 11.38 570 72547 168165 70687162
Hypervolaemia 256.41 11.38 257 72860 39449 70815878
Transfusion 249.38 11.38 184 72933 18652 70836675
Pain in jaw 239.19 11.38 256 72861 42413 70812914
Drug ineffective 236.47 11.38 379 72738 939373 69915954
Oxygen therapy 219.56 11.38 86 73031 2376 70852951
Pneumonia 214.48 11.38 1192 71925 595040 70260287
Acute respiratory failure 207.34 11.38 266 72851 53399 70801928
Rheumatoid arthritis 204.48 11.38 29 73088 291776 70563551
Completed suicide 202.93 11.38 7 73110 227128 70628199
Toxicity to various agents 198.61 11.38 73 73044 382099 70473228
Nasal congestion 195.58 11.38 287 72830 65385 70789942
Concomitant disease aggravated 189.49 11.38 131 72986 11983 70843344
Oedema peripheral 164.45 11.38 563 72554 227528 70627799
Pulmonary oedema 141.88 11.38 282 72835 81996 70773331
Cough 138.23 11.38 682 72435 324695 70530632
Oedema 135.03 11.38 317 72800 103264 70752063
Pulmonary arterial pressure increased 130.26 11.38 71 73046 4238 70851089
Catheter site erythema 123.74 11.38 72 73045 4876 70850451
Drug abuse 117.51 11.38 9 73108 147247 70708080
Cardiac failure 112.85 11.38 365 72752 143176 70712151
Contraindicated product administered 110.98 11.38 7 73110 134605 70720722
Brain natriuretic peptide increased 108.54 11.38 80 73037 8091 70847236
Therapeutic product effect decreased 108.01 11.38 11 73106 143007 70712320
Catheter site pruritus 107.58 11.38 50 73067 2121 70853206
Treatment failure 101.64 11.38 14 73103 144128 70711199
Lung transplant 100.90 11.38 60 73057 4230 70851097
Chest pain 99.80 11.38 517 72600 250743 70604584
Headache 98.44 11.38 971 72146 579434 70275893
Neutropenia 98.20 11.38 73 73044 257083 70598244
Productive cough 98.01 11.38 236 72881 78101 70777226
Blood pressure decreased 95.08 11.38 257 72860 91258 70764069
Haemoptysis 93.10 11.38 180 72937 51272 70804055
Arthropathy 91.88 11.38 21 73096 150036 70705291
Hypercapnia 91.86 11.38 73 73044 8256 70847071
Catheter management 88.26 11.38 51 73066 3408 70851919
Drug intolerance 86.24 11.38 64 73053 225623 70629704
Catheterisation cardiac 84.87 11.38 58 73059 5205 70850122
Alopecia 82.92 11.38 51 73066 198439 70656888
Drug hypersensitivity 81.72 11.38 90 73027 262369 70592958
Epistaxis 80.65 11.38 261 72856 102366 70752961
Respiratory distress 76.41 11.38 172 72945 54478 70800849
Syncope 75.00 11.38 354 72763 165355 70689972
Cyanosis 72.80 11.38 104 73013 23102 70832225
Rash 71.30 11.38 278 72839 510284 70345043
Scleroderma 71.05 11.38 51 73066 4950 70850377
Joint swelling 70.19 11.38 95 73022 253116 70602211
Hand deformity 69.80 11.38 5 73112 86477 70768850
Catheter site pain 69.07 11.38 50 73067 4918 70850409
Pulmonary veno-occlusive disease 68.81 11.38 33 73084 1503 70853824
Thermal burn 67.60 11.38 55 73062 6431 70848896
Dependence on oxygen therapy 67.05 11.38 23 73094 431 70854896
Intentional overdose 66.09 11.38 11 73106 98424 70756903
Glossodynia 64.39 11.38 7 73110 86480 70768847
Hypotension 62.39 11.38 664 72453 403717 70451610
Unevaluable event 62.07 11.38 154 72963 51909 70803418
Catheter site discharge 61.93 11.38 35 73082 2242 70853085
Device alarm issue 61.68 11.38 33 73084 1897 70853430
Stomatitis 61.03 11.38 28 73089 128483 70726844
Condition aggravated 59.95 11.38 689 72428 426946 70428381
Pericarditis 57.91 11.38 9 73108 84696 70770631
Musculoskeletal stiffness 57.60 11.38 41 73076 147719 70707608
Chronic respiratory failure 56.02 11.38 35 73082 2697 70852630
Flushing 54.91 11.38 198 72919 81974 70773353
Pleural effusion 54.49 11.38 276 72841 132588 70722739
Catheter site infection 54.11 11.38 47 73070 6013 70849314
Cardiac failure congestive 53.89 11.38 279 72838 135178 70720149
Pericardial effusion 53.46 11.38 127 72990 41649 70813678
Palpitations 53.33 11.38 241 72876 110512 70744815
Pulmonary hypertensive crisis 52.74 11.38 18 73099 332 70854995
Device related infection 52.68 11.38 108 73009 32077 70823250
Overdose 51.93 11.38 59 73058 169686 70685641
Off label use 51.07 11.38 505 72612 742555 70112772
Suicide attempt 50.96 11.38 10 73107 79500 70775827
Hepatic enzyme increased 50.88 11.38 52 73065 156938 70698389
Dizziness 50.66 11.38 714 72403 463427 70391900
Arthralgia 50.56 11.38 308 72809 503082 70352245
Transplant evaluation 50.39 11.38 27 73090 1557 70853770
Therapeutic product effect incomplete 49.77 11.38 31 73086 119851 70735476
Air embolism 49.16 11.38 18 73099 411 70854916
Catheter placement 48.80 11.38 32 73085 2681 70852646
Systemic lupus erythematosus 48.70 11.38 22 73095 101880 70753447
Emphysema 47.99 11.38 68 73049 14992 70840335
Hypersensitivity 47.41 11.38 104 73013 229708 70625619
Infusion related reaction 47.15 11.38 82 73035 197452 70657875
Catheter site rash 46.56 11.38 22 73095 969 70854358
Psoriasis 45.88 11.38 22 73095 98411 70756916
Cor pulmonale 45.81 11.38 28 73089 2075 70853252
Injection site pain 42.81 11.38 35 73082 117584 70737743
Dyspnoea at rest 41.92 11.38 43 73074 6776 70848551
Lung disorder 41.08 11.38 161 72956 69323 70786004
Pulmonary function test decreased 40.21 11.38 42 73075 6759 70848568
Febrile neutropenia 40.08 11.38 95 73022 204223 70651104
Idiopathic pulmonary fibrosis 40.07 11.38 36 73081 4815 70850512
Anaesthetic complication 40.03 11.38 28 73089 2608 70852719
Brain scan abnormal 40.01 11.38 21 73096 1161 70854166
Infusion site pain 39.51 11.38 54 73063 11510 70843817
Nasal dryness 39.26 11.38 32 73085 3751 70851576
Confusional state 38.88 11.38 156 72961 284242 70571085
Cerebral artery thrombosis 38.74 11.38 20 73097 1068 70854259
Orthopnoea 38.47 11.38 48 73069 9360 70845967
Pulmonary congestion 38.36 11.38 82 73035 25072 70830255
Cardiac arrest 38.26 11.38 289 72828 159545 70695782
Pain 37.65 11.38 441 72676 628375 70226952
Walking distance test abnormal 36.78 11.38 17 73100 712 70854615
Hospitalisation 36.31 11.38 175 72942 82393 70772934
Malaise 35.83 11.38 636 72481 432296 70423031
Helicobacter infection 35.67 11.38 7 73110 55649 70799678
Intentional product use issue 35.41 11.38 43 73074 120099 70735228
Discomfort 35.22 11.38 34 73083 105402 70749925
Exercise tolerance decreased 35.21 11.38 43 73074 8205 70847122
Cardiac failure acute 35.13 11.38 64 73053 17423 70837904
Pneumothorax 34.62 11.38 80 73037 25766 70829561
Injection site erythema 34.44 11.38 16 73101 72908 70782419
Device occlusion 33.99 11.38 48 73069 10547 70844780
Coma 33.83 11.38 27 73090 91817 70763510
Mobility decreased 33.50 11.38 34 73083 102965 70752362
Urticaria 33.43 11.38 74 73043 162975 70692352
Suicidal ideation 33.29 11.38 15 73102 69581 70785746
Left ventricular failure 33.27 11.38 43 73074 8685 70846642
Hypoglycaemia 33.21 11.38 29 73088 94335 70760992
Pruritus 32.80 11.38 215 72902 345345 70509982
Oxygen saturation abnormal 32.62 11.38 29 73088 3825 70851502
Leukopenia 32.62 11.38 37 73080 106523 70748804
Injection site reaction 32.52 11.38 6 73111 49846 70805481
Catheter site haemorrhage 32.51 11.38 32 73085 4799 70850528
Blood cholesterol increased 32.38 11.38 13 73104 64591 70790736
Abdominal distension 32.00 11.38 201 72916 104468 70750859
Neuromuscular block prolonged 31.96 11.38 17 73100 966 70854361
Mucosal inflammation 31.87 11.38 15 73102 67835 70787492
Pulmonary arterial pressure abnormal 31.61 11.38 15 73102 667 70854660
Impaired healing 31.19 11.38 19 73098 74355 70780972
Hyponatraemia 30.94 11.38 75 73042 160012 70695315
Acute kidney injury 30.69 11.38 327 72790 474297 70381030
N-terminal prohormone brain natriuretic peptide increased 30.22 11.38 28 73089 3896 70851431
Central venous catheterisation 30.10 11.38 25 73092 3008 70852319
Death 29.89 11.38 712 72405 509349 70345978
Malignant neoplasm progression 29.52 11.38 50 73067 121689 70733638
Cardiac ablation 29.45 11.38 21 73096 2017 70853310
Irritable bowel syndrome 29.39 11.38 8 73109 50842 70804485
Aggression 29.20 11.38 7 73110 48439 70806888
Abdominal pain 28.98 11.38 220 72897 341907 70513420
Chest discomfort 28.70 11.38 223 72894 124158 70731169
Depression 28.55 11.38 107 73010 198867 70656460
Pulmonary capillary haemangiomatosis 28.39 11.38 8 73109 75 70855252
Subcutaneous emphysema 28.22 11.38 19 73098 1663 70853664
Concomitant disease progression 28.17 11.38 25 73092 3290 70852037
Cardiac pacemaker insertion 27.94 11.38 31 73086 5341 70849986
Cognitive disorder 27.83 11.38 14 73103 60942 70794385
Paracentesis 27.80 11.38 17 73100 1261 70854066
Aspiration pleural cavity 27.75 11.38 18 73099 1480 70853847
Catheter site scab 27.61 11.38 10 73107 221 70855106
Pulmonary alveolar haemorrhage 27.55 11.38 43 73074 10326 70845001
Device connection issue 27.50 11.38 15 73102 896 70854431
Drug interaction 27.47 11.38 256 72861 381185 70474142
Ventilation perfusion mismatch 27.23 11.38 11 73106 330 70854997
Carbon dioxide increased 27.11 11.38 20 73097 2025 70853302
Catheter removal 27.03 11.38 13 73104 596 70854731
Osteonecrosis of jaw 26.60 11.38 5 73112 40997 70814330
Interstitial lung disease 26.58 11.38 192 72925 104493 70750834
Stevens-Johnson syndrome 26.49 11.38 3 73114 35904 70819423
Nocturnal dyspnoea 26.47 11.38 17 73100 1374 70853953
Drug resistance 26.23 11.38 4 73113 38186 70817141
Catheter site warmth 26.13 11.38 10 73107 259 70855068
Respiratory tract infection 25.67 11.38 99 73018 42299 70813028
Presyncope 25.67 11.38 91 73026 37347 70817980
Rash maculo-papular 25.61 11.38 10 73107 50535 70804792
Tachypnoea 25.40 11.38 76 73041 28562 70826765
Peripheral swelling 25.36 11.38 363 72754 236200 70619127
Bronchitis 25.29 11.38 207 72910 117036 70738291
Atrial flutter 25.15 11.38 61 73056 20266 70835061
Injection site pruritus 24.98 11.38 5 73112 39205 70816122
Heart rate increased 24.87 11.38 191 72926 105957 70749370
Pulseless electrical activity 24.84 11.38 47 73070 13168 70842159
Neuromuscular blockade 24.79 11.38 12 73105 558 70854769
Acute right ventricular failure 24.72 11.38 10 73107 301 70855026
Blister 24.64 11.38 41 73076 100485 70754842
Thrombocytopenia 24.63 11.38 145 72972 238965 70616362
Cardiomegaly 24.54 11.38 68 73049 24477 70830850
Right ventricular dysfunction 24.54 11.38 20 73097 2344 70852983
Neoplasm progression 24.53 11.38 8 73109 45220 70810107
Hyperthermia malignant 24.49 11.38 21 73096 2640 70852687
Rhabdomyolysis 24.46 11.38 38 73079 95722 70759605
Product use in unapproved indication 24.02 11.38 121 72996 207357 70647970
Accidental underdose 23.98 11.38 13 73104 767 70854560
Congestive hepatopathy 23.80 11.38 25 73092 4049 70851278
Pulmonary function test abnormal 23.64 11.38 23 73094 3402 70851925
Tracheostomy 23.51 11.38 15 73102 1199 70854128
Catheter site inflammation 23.22 11.38 14 73103 1012 70854315
Rhinorrhoea 23.19 11.38 132 72985 66239 70789088
Oxygen consumption 22.98 11.38 7 73110 88 70855239
Bone marrow failure 22.76 11.38 11 73106 48999 70806328
Sputum discoloured 22.71 11.38 56 73061 18795 70836532
Multiple sclerosis relapse 22.65 11.38 8 73109 43009 70812318
Wound 22.63 11.38 42 73075 98690 70756637
Device leakage 22.54 11.38 37 73080 9271 70846056
Neutrophil count decreased 22.47 11.38 32 73085 83524 70771803
Colitis ulcerative 22.30 11.38 4 73113 33919 70821408
Apnoea 22.27 11.38 40 73077 10769 70844558
Hepatitis 22.05 11.38 12 73105 49968 70805359
Colitis 21.99 11.38 20 73097 63794 70791533
Cardiac disorder 21.98 11.38 120 72997 59295 70796032
Psychotic disorder 21.66 11.38 6 73111 37695 70817632
Seizure 21.63 11.38 102 73015 177860 70677467
Cytomegalovirus infection 21.62 11.38 7 73110 39751 70815576
Mediastinal effusion 21.51 11.38 6 73111 54 70855273
Catheter site swelling 21.43 11.38 16 73101 1650 70853677
Infusion site infection 21.28 11.38 16 73101 1667 70853660
Gamma-glutamyltransferase increased 21.26 11.38 106 73011 50579 70804748
Catheter site granuloma 21.22 11.38 6 73111 57 70855270
Procedural complication 21.14 11.38 32 73085 7482 70847845
Injection site swelling 21.12 11.38 9 73108 43148 70812179
Feeling abnormal 21.08 11.38 232 72885 142087 70713240
Hypertension 20.74 11.38 200 72917 295833 70559494
Secretion discharge 20.69 11.38 43 73074 12890 70842437
Red blood cell sedimentation rate increased 20.67 11.38 7 73110 38635 70816692
Mouth ulceration 20.63 11.38 5 73112 34344 70820983
Rhonchi 20.59 11.38 22 73095 3633 70851694
Myocardial infarction 20.49 11.38 99 73018 171546 70683781
Agranulocytosis 20.37 11.38 8 73109 40290 70815037
Angioplasty 20.33 11.38 16 73101 1784 70853543
Inappropriate schedule of product administration 20.29 11.38 51 73066 107504 70747823
Pneumomediastinum 20.26 11.38 21 73096 3349 70851978
Anaesthetic complication cardiac 20.19 11.38 6 73111 69 70855258
Diabetic ketoacidosis 20.11 11.38 4 73113 31508 70823819
Platelet transfusion 20.08 11.38 17 73100 2101 70853226
Maternal exposure during pregnancy 20.02 11.38 57 73060 115288 70740039
Infusion site erythema 19.68 11.38 31 73086 7504 70847823
Right-to-left cardiac shunt 19.65 11.38 8 73109 245 70855082
Tubulointerstitial nephritis 19.50 11.38 5 73112 33071 70822256
Therapy non-responder 19.48 11.38 141 72976 76774 70778553
Atrial fibrillation 19.40 11.38 282 72835 184066 70671261
Uterine hypotonus 19.31 11.38 6 73111 81 70855246
Decreased activity 19.25 11.38 31 73086 7643 70847684
White blood cell count decreased 19.25 11.38 100 73017 170041 70685286
Abdominal cavity drainage 19.16 11.38 11 73106 726 70854601
Supraventricular tachycardia 19.11 11.38 54 73063 19656 70835671
Blood pressure increased 19.04 11.38 115 73002 188402 70666925
Neuropathy peripheral 19.01 11.38 67 73050 126829 70728498
Ascites 18.98 11.38 127 72990 67420 70787907
Emergency care 18.96 11.38 12 73105 946 70854381
C-reactive protein increased 18.90 11.38 55 73062 110462 70744865
Bronchospasm 18.83 11.38 59 73058 22733 70832594
Hallucination 18.78 11.38 31 73086 76229 70779098
Knee arthroplasty 18.72 11.38 6 73111 34295 70821032
Product use issue 18.58 11.38 109 73008 179828 70675499
Pulmonary artery banding 18.51 11.38 4 73113 10 70855317
Iron deficiency anaemia 18.40 11.38 59 73058 23013 70832314
Pulmonary artery dilatation 18.34 11.38 9 73108 431 70854896
Glossoptosis 17.98 11.38 7 73110 190 70855137
Pancreatitis 17.86 11.38 23 73094 62645 70792682
Blood alkaline phosphatase increased 17.64 11.38 112 73005 58409 70796918
Areflexia 17.62 11.38 24 73093 5098 70850229
Upper respiratory tract inflammation 17.56 11.38 21 73096 3921 70851406
Aspartate aminotransferase increased 17.45 11.38 204 72913 126774 70728553
Rotavirus infection 17.45 11.38 10 73107 658 70854669
Jugular vein distension 17.44 11.38 13 73104 1337 70853990
Respiratory acidosis 17.42 11.38 35 73082 10246 70845081
Eosinophilia 17.32 11.38 10 73107 40309 70815018
Ventricular tachycardia 17.32 11.38 79 73038 36344 70818983
Acute postoperative sialadenitis 17.28 11.38 5 73112 52 70855275
Cerebral haemorrhage 17.26 11.38 18 73099 53846 70801481
Brain hypoxia 17.19 11.38 11 73106 884 70854443
Choking sensation 17.16 11.38 20 73097 3635 70851692
Right ventricular enlargement 16.72 11.38 9 73108 524 70854803
Cerebral infarction 16.66 11.38 12 73105 42997 70812330
Right ventricular systolic pressure increased 16.64 11.38 11 73106 934 70854393
Exposure during pregnancy 16.23 11.38 42 73075 87675 70767652
Complication associated with device 16.17 11.38 44 73073 15669 70839658
Burns second degree 16.11 11.38 11 73106 985 70854342
Catheter site irritation 16.03 11.38 9 73108 569 70854758
Urine output decreased 15.97 11.38 46 73071 16924 70838403
Weight increased 15.93 11.38 344 72773 241987 70613340
Argon plasma coagulation 15.90 11.38 4 73113 23 70855304
Burns third degree 15.88 11.38 8 73109 406 70854921
Exercise test abnormal 15.86 11.38 5 73112 71 70855256
Pulmonary haemorrhage 15.82 11.38 40 73077 13633 70841694
Jaundice 15.77 11.38 17 73100 50091 70805236
Rales 15.70 11.38 46 73071 17089 70838238
Sinus disorder 15.59 11.38 49 73068 18910 70836417
Oral herpes 15.58 11.38 3 73114 24183 70831144
Cold burn 15.56 11.38 3 73114 3 70855324
Middle ear effusion 15.56 11.38 15 73102 2194 70853133
Injection site bruising 15.55 11.38 10 73107 38022 70817305
Rehabilitation therapy 15.53 11.38 13 73104 1582 70853745
Lower respiratory tract infection 15.52 11.38 61 73056 111852 70743475
Mechanical ventilation 15.37 11.38 16 73101 2565 70852762
Respiratory syncytial virus infection 15.36 11.38 28 73089 7627 70847700
Fibromyalgia 15.34 11.38 16 73101 47858 70807469
Cholestasis 15.34 11.38 16 73101 47856 70807471
Hepatocellular injury 15.23 11.38 15 73102 46076 70809251
Hospice care 15.19 11.38 29 73088 8176 70847151
Liver injury 15.19 11.38 12 73105 41023 70814304
Cardioversion 15.16 11.38 14 73103 1940 70853387
Dizziness postural 15.11 11.38 33 73084 10235 70845092
Procedural hypotension 15.09 11.38 14 73103 1952 70853375
Right ventricular dilatation 15.04 11.38 13 73104 1652 70853675
Product dose omission issue 15.04 11.38 311 72806 217157 70638170
PaO2/FiO2 ratio decreased 14.98 11.38 4 73113 30 70855297
Emotional distress 14.90 11.38 10 73107 37178 70818149
Inappropriate antidiuretic hormone secretion 14.76 11.38 3 73114 23273 70832054
COVID-19 pneumonia 14.72 11.38 53 73064 21916 70833411
Localised oedema 14.70 11.38 27 73090 7394 70847933
Angioedema 14.68 11.38 29 73088 66581 70788746
Barotrauma 14.49 11.38 6 73111 192 70855135
Decreased appetite 14.47 11.38 414 72703 304366 70550961
Agonal respiration 14.35 11.38 3 73114 6 70855321
Airway burns 14.35 11.38 3 73114 6 70855321
Poisoning 14.17 11.38 3 73114 22619 70832708
Paradoxical embolism 14.15 11.38 4 73113 38 70855289
Osteoarthritis 14.11 11.38 35 73082 74112 70781215
Catheter site hypersensitivity 13.91 11.38 5 73112 108 70855219
Incorrect dose administered 13.90 11.38 30 73087 66689 70788638
Pulmonary fibrosis 13.85 11.38 71 73046 34239 70821088
Accident 13.79 11.38 26 73091 7265 70848062
Delayed recovery from anaesthesia 13.75 11.38 12 73105 1545 70853782
Palmar-plantar erythrodysaesthesia syndrome 13.73 11.38 7 73110 30240 70825087
Disease progression 13.57 11.38 232 72885 156440 70698887
Breath sounds abnormal 13.57 11.38 37 73080 13194 70842133
Paraesthesia 13.56 11.38 91 73026 145446 70709881
Lung assist device therapy 13.50 11.38 5 73112 118 70855209
Rash pruritic 13.39 11.38 28 73089 62963 70792364
Terminal state 13.36 11.38 20 73097 4632 70850695
Wheezing 13.25 11.38 152 72965 94018 70761309
Blood creatine phosphokinase increased 13.22 11.38 27 73090 61236 70794091
Chronic left ventricular failure 13.18 11.38 9 73108 806 70854521
Pulmonary pain 13.11 11.38 17 73100 3445 70851882
Drug level increased 13.08 11.38 11 73106 36458 70818869
Thoracic cavity drainage 13.05 11.38 6 73111 248 70855079
Ill-defined disorder 12.80 11.38 23 73094 54718 70800609
Herpes zoster 12.77 11.38 45 73072 85190 70770137
Large intestinal polypectomy 12.66 11.38 6 73111 266 70855061
Vena cava filter insertion 12.63 11.38 5 73112 142 70855185
Blood carbon monoxide increased 12.63 11.38 3 73114 13 70855314
Systemic scleroderma 12.55 11.38 10 73107 1135 70854192
Right ventricular hypertrophy 12.52 11.38 11 73106 1429 70853898
Bradycardia 12.46 11.38 189 72928 124426 70730901
Basal cell carcinoma 12.29 11.38 10 73107 33688 70821639
Menstrual discomfort 12.28 11.38 3 73114 15 70855312
Myelosuppression 12.22 11.38 8 73109 30137 70825190
Atrial tachycardia 12.15 11.38 17 73100 3703 70851624
Cardiorenal syndrome 12.10 11.38 11 73106 1493 70853834
Plasma cell myeloma 12.10 11.38 37 73080 73164 70782163
Catheter site erosion 12.08 11.38 4 73113 67 70855260
Pulmonary vein stenosis 12.08 11.38 5 73112 160 70855167
Oedematous kidney 12.08 11.38 5 73112 160 70855167
Gastrointestinal tube insertion 12.04 11.38 11 73106 1503 70853824
Gastrointestinal arteriovenous malformation 12.04 11.38 9 73108 930 70854397
Frostbite 11.99 11.38 5 73112 163 70855164
Head injury 11.99 11.38 68 73049 34073 70821254
Puncture site infection 11.97 11.38 4 73113 69 70855258
Retching 11.96 11.38 40 73077 15939 70839388
Disturbance in attention 11.96 11.38 16 73101 42878 70812449
Lung infiltration 11.89 11.38 49 73068 21575 70833752
Oesophageal dilation procedure 11.86 11.38 4 73113 71 70855256
Joint range of motion decreased 11.85 11.38 6 73111 26020 70829307
Sopor 11.75 11.38 9 73108 31258 70824069
Haematoma evacuation 11.74 11.38 6 73111 314 70855013
Sinus congestion 11.71 11.38 42 73075 17331 70837996
Proteinuria 11.64 11.38 8 73109 29366 70825961
Upper respiratory tract infection 11.63 11.38 129 72988 79145 70776182
Nasal operation 11.58 11.38 5 73112 178 70855149
Stress cardiomyopathy 11.57 11.38 29 73088 9833 70845494
Product supply issue 11.55 11.38 11 73106 1584 70853743
Right ventricular systolic pressure 11.55 11.38 3 73114 20 70855307
Lung squamous cell carcinoma stage I 11.55 11.38 3 73114 20 70855307
Blood triglycerides increased 11.54 11.38 3 73114 19661 70835666
Nasal discomfort 11.51 11.38 19 73098 4782 70850545
Catheter site vesicles 11.51 11.38 6 73111 327 70855000
Sedation 11.50 11.38 19 73098 46712 70808615
Rhinovirus infection 11.50 11.38 23 73094 6710 70848617
Multiple allergies 11.49 11.38 25 73092 7735 70847592
Cardiac septal defect repair 11.42 11.38 3 73114 21 70855306
Ventricular extrasystoles 11.40 11.38 43 73074 18183 70837144
Polypectomy 11.38 11.38 9 73108 1010 70854317

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AN04 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:33937 macronutrients

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Persistent pulmonary hypertension of the newborn indication 233815004 DOID:13042
Methemoglobinemia contraindication 38959009 DOID:10783
Left heart failure contraindication 85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
None (Med Gas) Air Liquide Industrial U.S. L.P. 2
None (Med Gas) Air Liquide Large Industries U.S. L.P. 2
None (Med Gas) Messer LLC 2
None (Med Gas) Norco Inc. 2
None (Med Gas) Messer Gas Puerto Rico Inc. 2
None (Med Gas) Air Liquide America L.P. 2
None (Med Gas) Airgas Merchant Gases LLC 2
None (Med Gas) Praxair Inc. 2
None (Med Gas) Aspen Air, US Corp 2
None (Med Gas) Air Products and Chemicals Inc. 2
None (Med Gas) Matheson Tri-Gas Inc. 2
None (Med Gas) Praxair Canada Inc. 2
None (Med Gas) Airgas USA LLC 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019163 VUID
N0000147408 NUI
D00083 KEGG_DRUG
4019163 VANDF
C0028158 UMLSCUI
CHEBI:25555 CHEBI
NGN PDB_CHEM_ID
CHEMBL142438 ChEMBL_ID
D009584 MESH_DESCRIPTOR_UI
DB09152 DRUGBANK_ID
N762921K75 UNII
947 PUBCHEM_CID
7456 RXNORM
002515 NDDF
36012007 SNOMEDCT_US
767123001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10006-005 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10018-9502 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-003 LIQUID 990 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-020 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-021 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-022 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-023 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10678-002 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10690-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections