nitrogen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4251	7727-37-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nitrogen molecular nitrogen nitrogen gas nitrogen, nf	An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells. Molecular weight: 28.01 Formula: N2 CLOGP: LIPINSKI: None HAC: 2 HDO: 0 TPSA: 47.58 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

nitrogen
molecular nitrogen
nitrogen gas
nitrogen, nf

An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.

Molecular weight: 28.01
Formula: N2
CLOGP:
LIPINSKI: None
HAC: 2
HDO: 0
TPSA: 47.58
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	929.48	12.29	1960	57641	659353	62770068
Pulmonary arterial hypertension	716.07	12.29	372	59229	22205	63407216
Oxygen saturation decreased	608.47	12.29	568	59033	88017	63341404
Pulmonary hypertension	532.81	12.29	367	59234	36756	63392665
Oxygen consumption increased	475.53	12.29	167	59434	3717	63425704
Right ventricular failure	454.45	12.29	251	59350	16937	63412484
Dyspnoea exertional	401.01	12.29	380	59221	59922	63369499
Fluid retention	379.61	12.29	367	59234	59319	63370102
Drug ineffective	366.80	12.29	270	59331	1044495	62384926
Respiratory failure	299.54	12.29	421	59180	101437	63327984
Hypoxia	293.72	12.29	320	59281	59472	63369949
Chronic obstructive pulmonary disease	293.26	12.29	327	59274	62359	63367062
Hypervolaemia	221.83	12.29	196	59405	28217	63401204
Pneumonia	221.72	12.29	931	58670	455836	62973585
Oxygen therapy	219.12	12.29	81	59520	2097	63427324
Transfusion	203.15	12.29	144	59457	15073	63414348
Contraindicated product administered	189.00	12.29	3	59598	217645	63211776
Pain in jaw	176.62	12.29	211	59390	43285	63386136
Nasal congestion	163.38	12.29	251	59350	65409	63364012
Oedema peripheral	160.37	12.29	465	59136	189046	63240375
Acute respiratory failure	159.65	12.29	179	59422	34306	63395115
Arthropathy	157.67	12.29	18	59583	234774	63194647
Treatment failure	157.14	12.29	7	59594	199036	63230385
Alopecia	152.64	12.29	63	59538	337473	63091948
Cough	149.75	12.29	607	58994	292136	63137285
Cardiac failure	145.83	12.29	283	59318	88859	63340562
Productive cough	141.20	12.29	230	59371	62978	63366443
Drug intolerance	138.91	12.29	58	59543	308603	63120818
Glossodynia	138.90	12.29	7	59594	178869	63250552
Rheumatoid arthritis	138.43	12.29	34	59567	253785	63175636
Therapeutic product effect decreased	137.01	12.29	12	59589	193175	63236246
Hand deformity	127.87	12.29	5	59596	159452	63269969
Joint swelling	123.02	12.29	78	59523	327588	63101833
Pulmonary oedema	121.64	12.29	199	59402	54674	63374747
Systemic lupus erythematosus	119.87	12.29	25	59576	208893	63220528
Pulmonary arterial pressure increased	118.97	12.29	61	59540	3534	63425887
Rash	117.99	12.29	217	59384	560654	62868767
Chest pain	113.67	12.29	452	59149	215507	63213914
Concomitant disease aggravated	109.69	12.29	81	59520	9031	63420390
Toxicity to various agents	107.18	12.29	49	59552	247201	63182220
Epistaxis	101.24	12.29	216	59385	72509	63356912
Drug hypersensitivity	100.99	12.29	86	59515	310601	63118820
Haemoptysis	99.97	12.29	129	59472	28597	63400824
Oedema	96.80	12.29	254	59347	97368	63332053
Catheter site erythema	95.63	12.29	56	59545	4220	63425201
Catheter site pruritus	94.23	12.29	44	59557	2076	63427345
Musculoskeletal stiffness	89.13	12.29	31	59570	184587	63244834
Lung transplant	89.07	12.29	48	59553	3080	63426341
Discomfort	88.18	12.29	24	59577	167350	63262071
Hepatic enzyme increased	86.27	12.29	41	59560	202287	63227134
Blood pressure decreased	85.79	12.29	189	59412	64833	63364588
Syncope	85.09	12.29	273	59328	117112	63312309
Hypercapnia	80.93	12.29	55	59546	5376	63424045
Pericarditis	79.14	12.29	14	59587	131565	63297856
Wound	77.80	12.29	28	59573	163235	63266186
Dependence on oxygen therapy	77.33	12.29	25	59576	427	63428994
Catheter management	77.21	12.29	43	59558	2944	63426477
Off label use	76.36	12.29	350	59251	674112	62755309
Cardiac failure congestive	76.32	12.29	225	59376	92208	63337213
Brain natriuretic peptide increased	75.80	12.29	52	59549	5161	63424260
Arthralgia	74.17	12.29	280	59321	569430	62859991
Psoriatic arthropathy	72.91	12.29	3	59598	91517	63337904
Headache	72.34	12.29	909	58692	632332	62797089
Hypersensitivity	71.94	12.29	102	59499	292583	63136838
Scleroderma	71.30	12.29	51	59550	5411	63424010
Hypotension	68.38	12.29	464	59137	272140	63157281
Infusion related reaction	66.02	12.29	80	59521	245441	63183980
Stomatitis	65.74	12.29	24	59577	138701	63290720
Death	65.51	12.29	586	59015	373795	63055626
Catheterisation cardiac	62.44	12.29	44	59557	4559	63424862
Product use issue	60.19	12.29	71	59530	220449	63208972
Device alarm issue	59.59	12.29	29	59572	1501	63427920
Pleural effusion	58.86	12.29	207	59394	93003	63336418
Palpitations	58.40	12.29	235	59366	112535	63316886
Pain	55.91	12.29	437	59164	740191	62689230
Pulmonary veno-occlusive disease	55.25	12.29	25	59576	1096	63428325
Neutropenia	54.92	12.29	50	59551	174955	63254466
Pericardial effusion	54.78	12.29	100	59501	29958	63399463
Cor pulmonale	54.27	12.29	30	59571	2024	63427397
Blister	54.25	12.29	27	59574	129787	63299634
Cyanosis	54.20	12.29	73	59528	16862	63412559
Therapeutic product effect incomplete	53.80	12.29	25	59576	125031	63304390
Flushing	52.90	12.29	173	59428	74914	63354507
Drug abuse	52.77	12.29	4	59597	72514	63356907
Dizziness	52.35	12.29	625	58976	429300	63000121
Catheter site pain	52.34	12.29	40	59561	4695	63424726
Unevaluable event	52.23	12.29	135	59466	51251	63378170
Maternal exposure during pregnancy	51.78	12.29	79	59522	219983	63209438
Blood cholesterol increased	50.42	12.29	13	59588	94019	63335402
Impaired healing	49.84	12.29	17	59584	102525	63326896
Chest discomfort	49.81	12.29	220	59381	109749	63319672
Malaise	48.58	12.29	600	59001	415354	63014067
Device related infection	48.03	12.29	82	59519	23310	63406111
Pruritus	48.01	12.29	176	59425	361277	63068144
Respiratory distress	47.41	12.29	101	59500	33850	63395571
Irritable bowel syndrome	46.94	12.29	10	59591	82402	63347019
Catheter site infection	46.75	12.29	38	59563	4876	63424545
Catheter site discharge	46.70	12.29	27	59574	1986	63427435
Orthopnoea	46.48	12.29	42	59559	6219	63423202
Dyspnoea at rest	46.28	12.29	35	59566	4044	63425377
Bronchitis	45.72	12.29	235	59366	124700	63304721
Exercise tolerance decreased	45.05	12.29	39	59562	5458	63423963
Intentional overdose	44.34	12.29	8	59593	74144	63355277
Exposure during pregnancy	43.60	12.29	49	59552	155498	63273923
Air embolism	42.67	12.29	14	59587	251	63429170
Infusion site pain	42.64	12.29	65	59536	16804	63412617
Respiratory tract infection	42.17	12.29	109	59492	41374	63388047
Left ventricular failure	41.93	12.29	38	59563	5649	63423772
Injection site erythema	41.81	12.29	13	59588	83161	63346260
Transplant evaluation	41.61	12.29	21	59580	1176	63428245
Catheter site rash	40.53	12.29	18	59583	755	63428666
Suicide attempt	40.03	12.29	5	59596	60913	63368508
Hospitalisation	39.88	12.29	172	59429	84909	63344512
Chronic respiratory failure	39.63	12.29	24	59577	1923	63427498
Injection site pain	38.48	12.29	39	59562	129761	63299660
Mobility decreased	37.54	12.29	35	59566	121124	63308297
Liver injury	37.35	12.29	6	59595	60514	63368907
Intentional product use issue	37.26	12.29	39	59562	127853	63301568
Pulmonary arterial pressure abnormal	36.78	12.29	15	59586	508	63428913
Urticaria	36.65	12.29	62	59539	165740	63263681
Lung disorder	36.51	12.29	135	59466	62126	63367295
Swelling	35.94	12.29	135	59466	275243	63154178
Atrial flutter	35.75	12.29	45	59556	9727	63419694
Pulmonary congestion	35.68	12.29	61	59540	17357	63412064
Oxygen saturation abnormal	35.08	12.29	28	59573	3501	63425920
Psoriasis	34.97	12.29	19	59582	86938	63342483
Abdominal distension	34.57	12.29	167	59434	86448	63342973
Nasal dryness	34.54	12.29	31	59570	4550	63424871
Cardiac disorder	33.93	12.29	115	59486	50701	63378720
Cardiac arrest	33.79	12.29	174	59427	92371	63337050
Atrial fibrillation	33.77	12.29	206	59395	116430	63312991
Presyncope	33.55	12.29	78	59523	27707	63401714
Injection site reaction	33.54	12.29	7	59594	58517	63370904
Ascites	32.51	12.29	98	59503	40630	63388791
Subcutaneous emphysema	32.49	12.29	16	59585	850	63428571
Aspiration pleural cavity	32.47	12.29	16	59585	851	63428570
Bladder agenesis	32.20	12.29	10	59591	149	63429272
Interstitial lung disease	32.02	12.29	129	59472	61779	63367642
Cardiac failure acute	31.93	12.29	42	59559	9481	63419940
Oxygen consumption	31.90	12.29	9	59592	94	63429327
Genitalia external ambiguous	31.77	12.29	10	59591	156	63429265
Cloacal exstrophy	31.77	12.29	10	59591	156	63429265
Emphysema	31.77	12.29	45	59556	10893	63418528
Pulmonary hypertensive crisis	31.71	12.29	12	59589	332	63429089
Congenital ectopic bladder	31.56	12.29	9	59592	98	63429323
Overdose	31.43	12.29	37	59564	115041	63314380
Catheter placement	31.37	12.29	22	59579	2262	63427159
Ill-defined disorder	31.25	12.29	19	59582	81736	63347685
Product use in unapproved indication	31.06	12.29	77	59524	179003	63250418
Abdominal discomfort	30.78	12.29	176	59425	320709	63108712
Oedematous kidney	30.54	12.29	9	59592	111	63429310
Febrile neutropenia	30.34	12.29	40	59561	118409	63311012
Anaemia	30.30	12.29	414	59187	293016	63136405
Meconium stain	29.89	12.29	10	59591	191	63429230
Cardiac pacemaker insertion	29.30	12.29	27	59574	4099	63425322
Thermal burn	29.03	12.29	32	59569	6014	63423407
Gastrointestinal disorder congenital	28.92	12.29	9	59592	135	63429286
Central venous catheterisation	28.82	12.29	22	59579	2577	63426844
Congenital genital malformation	28.21	12.29	9	59592	147	63429274
Knee arthroplasty	28.10	12.29	8	59593	54198	63375223
Device leakage	28.09	12.29	34	59567	7062	63422359
Rales	28.05	12.29	46	59555	12651	63416770
Sputum discoloured	28.05	12.29	53	59548	16294	63413127
Paracentesis	27.94	12.29	15	59586	955	63428466
Gamma-glutamyltransferase increased	27.27	12.29	82	59519	33949	63395472
Lipodystrophy acquired	27.26	12.29	17	59584	1435	63427986
Caudal regression syndrome	27.10	12.29	9	59592	168	63429253
Device occlusion	27.00	12.29	34	59567	7353	63422068
Cardiac ablation	26.91	12.29	17	59584	1468	63427953
Gastrointestinal malformation	26.56	12.29	9	59592	179	63429242
Tethered cord syndrome	26.51	12.29	10	59591	274	63429147
Pulmonary function test decreased	26.44	12.29	25	59576	3922	63425499
Fibromyalgia	26.39	12.29	22	59579	80398	63349023
Lower respiratory tract infection	26.11	12.29	53	59548	132254	63297167
Product dose omission issue	26.00	12.29	335	59266	233978	63195443
Walking distance test abnormal	25.78	12.29	12	59589	562	63428859
Red blood cell sedimentation rate increased	25.74	12.29	5	59596	43977	63385444
Heart rate increased	25.74	12.29	164	59437	94074	63335347
N-terminal prohormone brain natriuretic peptide increased	25.54	12.29	19	59582	2142	63427279
Catheter site scab	25.30	12.29	9	59592	208	63429213
Anaesthetic complication	24.89	12.29	18	59583	1942	63427479
Adverse drug reaction	24.72	12.29	23	59578	79691	63349730
Osteoarthritis	24.62	12.29	32	59569	95311	63334110
Pneumothorax	24.60	12.29	50	59551	16211	63413210
Haemoglobin decreased	24.47	12.29	226	59375	145259	63284162
Catheter site swelling	24.44	12.29	16	59585	1469	63427952
Congestive hepatopathy	24.37	12.29	21	59580	2921	63426500
Cognitive disorder	24.24	12.29	11	59590	55804	63373617
Infusion site erythema	24.05	12.29	41	59560	11638	63417783
Pancreatitis haemorrhagic	23.50	12.29	11	59590	522	63428899
Anal atresia	23.25	12.29	10	59591	388	63429033
Upper respiratory tract infection	23.16	12.29	144	59457	81903	63347518
Confusional state	23.00	12.29	129	59472	236251	63193170
Injury	22.87	12.29	21	59580	73226	63356195
Injection site pruritus	22.76	12.29	7	59594	45109	63384312
Gout	22.74	12.29	43	59558	13228	63416193
Oedematous pancreatitis	22.59	12.29	11	59590	570	63428851
Neuromuscular blockade	22.52	12.29	9	59592	289	63429132
Anencephaly	22.26	12.29	9	59592	298	63429123
C-reactive protein increased	22.25	12.29	34	59567	94673	63334748
Nocturnal dyspnoea	22.15	12.29	14	59587	1210	63428211
Neural tube defect	22.13	12.29	8	59593	194	63429227
Haematocrit decreased	21.98	12.29	84	59517	39256	63390165
Blood iron decreased	21.95	12.29	45	59556	14676	63414745
Pulmonary trichosporonosis	21.87	12.29	6	59595	56	63429365
Suicidal ideation	21.84	12.29	16	59585	62405	63367016
Paraesthesia	21.75	12.29	75	59526	156891	63272530
Rhinorrhoea	21.69	12.29	120	59481	65457	63363964
Type 2 diabetes mellitus	21.55	12.29	17	59584	63851	63365570
Depression	21.50	12.29	103	59498	196389	63233032
Concomitant disease progression	21.36	12.29	17	59584	2117	63427304
Condition aggravated	21.35	12.29	511	59090	401706	63027715
Device connection issue	21.03	12.29	11	59590	664	63428757
Carbon dioxide increased	20.90	12.29	14	59587	1336	63428085
Upper respiratory tract inflammation	20.88	12.29	18	59583	2505	63426916
Iron deficiency anaemia	20.84	12.29	53	59548	19916	63409505
Gastrointestinal disorder	20.80	12.29	59	59542	131180	63298241
Cardiomegaly	20.77	12.29	49	59552	17565	63411856
Bursitis	20.08	12.29	5	59596	37036	63392385
Localised oedema	20.05	12.29	25	59576	5353	63424068
Stent placement	20.01	12.29	21	59580	3734	63425687
Leukopenia	19.89	12.29	26	59575	77264	63352157
Aspartate aminotransferase increased	19.86	12.29	149	59452	90128	63339293
Disease progression	19.79	12.29	189	59412	122569	63306852
Injection site swelling	19.70	12.29	10	59591	47562	63381859
Infusion site infection	19.49	12.29	15	59586	1779	63427642
Supraventricular tachycardia	19.40	12.29	42	59559	14229	63415192
Right ventricular dysfunction	19.30	12.29	15	59586	1804	63427617
Sepsis	19.17	12.29	224	59377	152899	63276522
Meningomyelocele	19.05	12.29	10	59591	608	63428813
Multiple sclerosis relapse	18.90	12.29	11	59590	48467	63380954
Pulmonary artery banding	18.89	12.29	4	59597	10	63429411
Feeling abnormal	18.54	12.29	217	59384	148175	63281246
Sepsis neonatal	18.47	12.29	9	59592	467	63428954
Umbilical cord abnormality	18.39	12.29	10	59591	653	63428768
Hyperandrogenism	18.32	12.29	6	59595	107	63429314
Hip arthroplasty	18.31	12.29	11	59590	47635	63381786
Uterine hypotonus	18.27	12.29	6	59595	108	63429313
Tachypnoea	18.14	12.29	46	59555	17256	63412165
Hepatic function abnormal	18.10	12.29	76	59525	37066	63392355
Lung assist device therapy	18.06	12.29	6	59595	112	63429309
Pulmonary alveolar haemorrhage	17.88	12.29	22	59579	4646	63424775
Mediastinal effusion	17.33	12.29	5	59596	57	63429364
Right ventricular systolic pressure increased	17.29	12.29	9	59592	538	63428883
PO2 decreased	17.26	12.29	13	59588	1493	63427928
Oxygen consumption decreased	17.22	12.29	7	59594	235	63429186
Pulmonary haemorrhage	17.21	12.29	27	59574	7154	63422267
Bronchospasm	17.14	12.29	45	59556	17235	63412186
Exomphalos	17.13	12.29	9	59592	548	63428873
Cardioversion	16.99	12.29	12	59589	1248	63428173
Malignant neoplasm progression	16.97	12.29	32	59569	82089	63347332
Osteonecrosis of jaw	16.76	12.29	6	59595	35117	63394304
Argon plasma coagulation	16.58	12.29	4	59597	21	63429400
Platelet transfusion	16.57	12.29	10	59591	796	63428625
Abdominal cavity drainage	16.53	12.29	8	59593	409	63429012
Enlarged clitoris	16.35	12.29	6	59595	152	63429269
Terminal state	16.34	12.29	15	59586	2267	63427154
Compartment syndrome	16.33	12.29	15	59586	2269	63427152
Coma	16.21	12.29	22	59579	64342	63365079
Rehabilitation therapy	16.21	12.29	13	59588	1637	63427784
Inflammation	16.19	12.29	33	59568	82240	63347181
Neoplasm progression	16.10	12.29	7	59594	36421	63393000
Pulmonary artery dilatation	16.03	12.29	7	59594	282	63429139
Pulmonary pain	15.94	12.29	18	59583	3472	63425949
Idiopathic pulmonary fibrosis	15.92	12.29	12	59589	1380	63428041
Angioedema	15.89	12.29	13	59588	47952	63381469
Acute postoperative sialadenitis	15.85	12.29	4	59597	26	63429395
Cold burn	15.84	12.29	3	59598	3	63429418
Tachycardia	15.75	12.29	175	59426	117981	63311440
Echocardiogram	15.72	12.29	4	59597	27	63429394
Rhinocerebral mucormycosis	15.70	12.29	8	59593	457	63428964
Pneumonia bacterial	15.39	12.29	30	59571	9435	63419986
Pulmonary capillary haemangiomatosis	15.36	12.29	4	59597	30	63429391
Tracheostomy	15.33	12.29	9	59592	681	63428740
Blood urea increased	15.29	12.29	57	59544	26322	63403099
Neuropathy peripheral	15.28	12.29	55	59546	113612	63315809
Procedural hypotension	15.28	12.29	11	59590	1179	63428242
Middle ear effusion	15.22	12.29	15	59586	2476	63426945
Oral herpes	15.18	12.29	3	59598	26071	63403350
Accident	14.90	12.29	23	59578	6009	63423412
Head injury	14.90	12.29	58	59543	27338	63402083
Live birth	14.82	12.29	3	59598	25627	63403794
Rhonchi	14.80	12.29	15	59586	2561	63426860
Systemic scleroderma	14.77	12.29	10	59591	971	63428450
Jugular vein distension	14.73	12.29	10	59591	976	63428445
Paradoxical embolism	14.71	12.29	4	59597	36	63429385
Hypoglycaemia	14.66	12.29	21	59580	60044	63369377
Neutrophil count decreased	14.49	12.29	19	59582	56387	63373034
Prescribed overdose	14.42	12.29	7	59594	34146	63395275
Catheter site warmth	14.40	12.29	6	59595	215	63429206
Injection site bruising	14.33	12.29	11	59590	41899	63387522
Catheter site hypersensitivity	14.20	12.29	5	59596	112	63429309
Hepatitis	14.18	12.29	10	59591	39778	63389643
Hypertension	14.18	12.29	181	59420	279122	63150299
Dizziness exertional	14.02	12.29	7	59594	383	63429038
Choking sensation	14.02	12.29	17	59584	3537	63425884
Bone marrow failure	13.98	12.29	5	59596	29285	63400136
Hospice care	13.96	12.29	26	59575	7906	63421515
Limb injury	13.90	12.29	54	59547	25423	63403998
Gastrointestinal arteriovenous malformation	13.89	12.29	8	59593	584	63428837
Catheter site haemorrhage	13.87	12.29	16	59585	3159	63426262
Biopsy liver	13.84	12.29	7	59594	394	63429027
Distributive shock	13.80	12.29	11	59590	1372	63428049
Chills	13.80	12.29	165	59436	113213	63316208
Spina bifida	13.52	12.29	9	59592	850	63428571
Pregnancy	13.47	12.29	9	59592	36827	63392594
Breath sounds abnormal	13.46	12.29	31	59570	10942	63418479
Pneumomediastinum	13.44	12.29	11	59590	1425	63427996
Catheter site inflammation	13.42	12.29	9	59592	860	63428561
Increased bronchial secretion	13.41	12.29	12	59589	1754	63427667
Therapy change	13.39	12.29	22	59579	6059	63423362
Secretion discharge	13.33	12.29	33	59568	12198	63417223
Colitis ulcerative	13.25	12.29	4	59597	26087	63403334
Red blood cell count decreased	13.18	12.29	74	59527	40571	63388850
Joint range of motion decreased	13.16	12.29	7	59594	32421	63397000
Urinary retention	13.11	12.29	6	59595	30295	63399126
COVID-19 pneumonia	13.09	12.29	36	59565	14173	63415248
Disease recurrence	13.01	12.29	5	59596	28025	63401396
Sinus congestion	12.97	12.29	42	59559	18081	63411340
Mucosal inflammation	12.90	12.29	15	59586	46913	63382508
Foot deformity	12.88	12.29	5	59596	27848	63401573
Abdominal pain	12.82	12.29	196	59405	293260	63136161
Decreased activity	12.77	12.29	22	59579	6298	63423123
Hypozincaemia	12.73	12.29	3	59598	14	63429407
Decreased appetite	12.70	12.29	317	59284	250735	63178686
Right ventricular hypertrophy	12.62	12.29	8	59593	695	63428726
Mastitis bacterial	12.62	12.29	4	59597	64	63429357
Catheter site erosion	12.56	12.29	4	59597	65	63429356
Vascular cauterisation	12.56	12.29	4	59597	65	63429356
Menstrual discomfort	12.56	12.29	3	59598	15	63429406
Cardiac failure high output	12.54	12.29	6	59595	299	63429122
Apnoea	12.53	12.29	25	59576	7997	63421424
Respiration abnormal	12.52	12.29	22	59579	6395	63423026
Weight decreased	12.42	12.29	344	59257	276454	63152967
Lung squamous cell carcinoma stage I	12.39	12.29	3	59598	16	63429405

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	356.38	11.76	902	28895	375880	34551254
Oxygen saturation decreased	323.62	11.76	307	29490	53511	34873623
Pulmonary arterial hypertension	314.20	11.76	152	29645	8587	34918547
Hypoxia	236.12	11.76	262	29535	54833	34872301
Right ventricular failure	204.10	11.76	114	29683	8670	34918464
Oxygen consumption increased	169.90	11.76	58	29739	1308	34925826
Pulmonary hypertension	166.55	11.76	140	29657	20784	34906350
Respiratory failure	148.47	11.76	302	29495	108270	34818864
Chronic obstructive pulmonary disease	137.19	11.76	188	29609	48730	34878404
Pneumonia	118.09	11.76	614	29183	362013	34565121
Fluid retention	115.28	11.76	128	29669	26759	34900375
Concomitant disease aggravated	113.72	11.76	67	29730	5634	34921500
Acute respiratory failure	94.52	11.76	124	29673	30804	34896330
Dyspnoea exertional	83.79	11.76	140	29657	43139	34883995
Toxicity to various agents	71.57	11.76	41	29756	200321	34726813
Pain in jaw	68.15	11.76	69	29728	12971	34914163
Oxygen therapy	66.49	11.76	26	29771	870	34926264
Thermal burn	65.43	11.76	36	29761	2655	34924479
Transfusion	63.29	11.76	55	29742	8530	34918604
Completed suicide	61.97	11.76	6	29791	98162	34828972
Hypervolaemia	57.09	11.76	77	29720	19632	34907502
Drug abuse	55.41	11.76	9	29788	99087	34828047
Cerebral artery thrombosis	52.18	11.76	21	29776	759	34926375
Nasal congestion	52.02	11.76	80	29717	22977	34904157
Pulmonary oedema	50.92	11.76	120	29677	47409	34879725
Respiratory distress	50.75	11.76	101	29696	35564	34891570
Brain scan abnormal	49.73	11.76	21	29776	859	34926275
Pneumothorax	48.45	11.76	70	29727	19022	34908112
Cough	47.67	11.76	253	29544	149887	34777247
Pulmonary arterial pressure increased	45.43	11.76	22	29775	1243	34925891
Haemoptysis	40.37	11.76	91	29706	34915	34892219
Hypercapnia	39.15	11.76	31	29766	4224	34922910
Drug ineffective	38.70	11.76	230	29567	456521	34470613
Neutropenia	37.65	11.76	47	29750	156731	34770403
Oedema	37.10	11.76	104	29693	45637	34881497
Lung transplant	35.74	11.76	22	29775	2002	34925132
Brain natriuretic peptide increased	35.30	11.76	33	29764	5626	34921508
Idiopathic pulmonary fibrosis	35.24	11.76	27	29770	3507	34923627
Cardiac arrest	33.23	11.76	166	29631	95993	34831141
Blood pressure decreased	33.18	11.76	108	29689	51407	34875727
Areflexia	32.08	11.76	24	29773	3007	34924127
Catheter site erythema	32.01	11.76	18	29779	1385	34925749
COVID-19 pneumonia	30.32	11.76	53	29744	16914	34910220
Catheter management	29.38	11.76	15	29782	950	34926184
Chronic respiratory failure	29.03	11.76	17	29780	1412	34925722
Catheter placement	29.03	11.76	14	29783	784	34926350
Emphysema	28.78	11.76	38	29759	9487	34917647
Cor pulmonale	28.73	11.76	14	29783	802	34926332
Cardiac failure	28.39	11.76	153	29644	91095	34836039
Lung disorder	28.24	11.76	79	29718	34617	34892517
Catheter site haemorrhage	26.69	11.76	19	29778	2205	34924929
Mechanical ventilation	26.38	11.76	18	29779	1952	34925182
Catheter removal	26.15	11.76	9	29788	208	34926926
Condition aggravated	25.48	11.76	263	29534	191933	34735201
Oedema peripheral	25.39	11.76	182	29615	119630	34807504
Neuromuscular block prolonged	25.17	11.76	11	29786	490	34926644
Productive cough	25.00	11.76	80	29717	37733	34889401
Cyanosis	24.29	11.76	41	29756	12723	34914411
Pulmonary function test abnormal	23.98	11.76	19	29778	2591	34924543
Rhinocerebral mucormycosis	23.84	11.76	11	29786	557	34926577
Respiratory tract infection	22.45	11.76	51	29746	19661	34907473
Intentional overdose	22.21	11.76	5	29792	43669	34883465
Transplant evaluation	21.87	11.76	10	29787	496	34926638
Air embolism	21.48	11.76	7	29790	136	34926998
Catheterisation cardiac	21.46	11.76	18	29779	2659	34924475
Pulmonary veno-occlusive disease	21.34	11.76	10	29787	525	34926609
Subacute combined cord degeneration	21.06	11.76	7	29790	145	34926989
Rotavirus infection	20.69	11.76	9	29788	396	34926738
Interstitial lung disease	20.66	11.76	110	29687	65172	34861962
Pulmonary fibrosis	20.29	11.76	47	29750	18349	34908785
Headache	20.07	11.76	260	29537	200375	34726759
Ventilation perfusion mismatch	20.04	11.76	6	29791	87	34927047
Hypotension	20.03	11.76	282	29515	221367	34705767
Catheter site granuloma	19.85	11.76	5	29792	36	34927098
Catheter site pain	19.78	11.76	13	29784	1325	34925809
Carbon dioxide increased	19.72	11.76	12	29785	1069	34926065
Catheter site discharge	19.59	11.76	10	29787	633	34926501
PaO2/FiO2 ratio decreased	19.50	11.76	5	29792	39	34927095
SARS-CoV-2 viraemia	19.50	11.76	5	29792	39	34927095
Anaesthetic complication	19.33	11.76	12	29785	1108	34926026
Epistaxis	19.01	11.76	99	29698	58152	34868982
Treatment failure	18.99	11.76	8	29789	46689	34880445
Catheter site pruritus	18.88	11.76	8	29789	330	34926804
Burns third degree	18.53	11.76	7	29790	213	34926921
Pulmonary function test decreased	18.47	11.76	22	29775	4953	34922181
Rheumatoid arthritis	18.23	11.76	5	29792	38233	34888901
Accident	18.21	11.76	22	29775	5025	34922109
Tachypnoea	18.21	11.76	45	29752	18307	34908827
Hyperthermia malignant	18.21	11.76	15	29782	2162	34924972
Catheter site warmth	18.13	11.76	5	29792	53	34927081
Abdominal pain	18.01	11.76	75	29722	163543	34763591
Bradycardia	18.00	11.76	118	29679	75300	34851834
White blood cell count decreased	17.73	11.76	34	29763	95411	34831723
Cardiac failure congestive	17.34	11.76	126	29671	83144	34843990
Pulmonary congestion	17.24	11.76	37	29760	13728	34913406
Pneumomediastinum	17.11	11.76	15	29782	2352	34924782
Therapeutic product effect incomplete	17.08	11.76	11	29786	50530	34876604
Aggression	16.96	11.76	6	29791	38958	34888176
Drug interaction	16.88	11.76	118	29679	225828	34701306
Pulmonary alveolar haemorrhage	16.84	11.76	26	29771	7486	34919648
Thyroglobulin increased	16.81	11.76	4	29793	22	34927112
Hyponatraemia	16.67	11.76	28	29769	82663	34844471
Respiratory acidosis	16.59	11.76	21	29776	5029	34922105
Confusional state	16.54	11.76	65	29732	144095	34783039
Pulmonary hypertensive crisis	16.38	11.76	6	29791	167	34926967
Hypocapnia	16.32	11.76	6	29791	169	34926965
Apnoea	16.27	11.76	24	29773	6640	34920494
Walking distance test abnormal	16.06	11.76	6	29791	177	34926957
Anaesthetic complication cardiac	15.86	11.76	4	29793	29	34927105
Superinfection fungal	15.86	11.76	4	29793	29	34927105
Pulse pressure decreased	15.84	11.76	6	29791	184	34926950
Thrombocytopenia	15.76	11.76	74	29723	156173	34770961
Alkalosis hypochloraemic	15.74	11.76	7	29790	325	34926809
Accidental underdose	15.68	11.76	8	29789	506	34926628
Ventricular tachycardia	15.58	11.76	54	29743	26525	34900609
Thoracic cavity drainage	15.51	11.76	6	29791	195	34926939
Barotrauma	15.19	11.76	4	29793	35	34927099
Infusion site vesicles	14.96	11.76	6	29791	215	34926919
Dependence on oxygen therapy	14.96	11.76	6	29791	215	34926919
Leukopenia	14.90	11.76	19	29778	62837	34864297
Pulseless electrical activity	14.84	11.76	24	29773	7187	34919947
Respiratory disorder	14.83	11.76	43	29754	19221	34907913
Catheter site inflammation	14.83	11.76	6	29791	220	34926914
Acute kidney injury	14.66	11.76	178	29619	304810	34622324
Bronchopulmonary aspergillosis	14.60	11.76	36	29761	14623	34912511
Pulmonary haemorrhage	14.43	11.76	29	29768	10275	34916859
Aspartate aminotransferase increased	14.36	11.76	103	29694	67680	34859454
Acute right ventricular failure	14.23	11.76	5	29792	123	34927011
Hemiplegia	14.07	11.76	23	29774	6949	34920185
Device intolerance	14.05	11.76	3	29794	9	34927125
Coma	14.05	11.76	11	29786	45667	34881467
Syncope	13.98	11.76	129	29668	91322	34835812
Suicide attempt	13.93	11.76	8	29789	39108	34888026
Complication associated with device	13.77	11.76	21	29776	5985	34921149
Mucosal inflammation	13.61	11.76	8	29789	38614	34888520
Haemodynamic instability	13.57	11.76	27	29770	9496	34917638
Myotonic dystrophy	13.49	11.76	5	29792	144	34926990
Rash maculo-papular	13.05	11.76	4	29793	28447	34898687
Electrocardiogram ST segment elevation	12.98	11.76	19	29778	5219	34921915
Device related infection	12.81	11.76	38	29759	17199	34909935
Procedural complication	12.80	11.76	17	29780	4266	34922868
Dyspnoea at rest	12.71	11.76	16	29781	3812	34923322
Febrile neutropenia	12.54	11.76	67	29730	136782	34790352
Therapeutic product effect decreased	12.53	11.76	7	29790	34736	34892398
Thoracotomy	12.51	11.76	4	29793	73	34927061
Myocardial infarction	12.41	11.76	57	29740	121028	34806106
Delayed recovery from anaesthesia	12.37	11.76	8	29789	793	34926341
Cardiac assistance device user	12.11	11.76	3	29794	20	34927114
Alopecia	11.96	11.76	3	29794	24352	34902782

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	1025.51	11.01	2430	74881	854595	78812482
Pulmonary arterial hypertension	944.42	11.01	488	76823	27878	79639199
Oxygen saturation decreased	779.06	11.01	782	76529	128265	79538812
Pulmonary hypertension	606.65	11.01	445	76866	47635	79619442
Oxygen consumption increased	579.86	11.01	208	77103	4771	79662306
Right ventricular failure	564.87	11.01	326	76985	23171	79643906
Fluid retention	474.94	11.01	452	76859	69357	79597720
Hypoxia	451.35	11.01	528	76783	102715	79564362
Dyspnoea exertional	410.36	11.01	463	76848	86610	79580467
Respiratory failure	308.35	11.01	595	76716	180316	79486761
Chronic obstructive pulmonary disease	299.31	11.01	391	76920	85028	79582049
Hypervolaemia	255.83	11.01	258	77053	42432	79624645
Drug ineffective	250.20	11.01	416	76895	1080497	78586580
Pain in jaw	246.11	11.01	262	77049	45889	79621188
Transfusion	243.43	11.01	186	77125	21144	79645933
Pneumonia	238.00	11.01	1263	76048	658983	79008094
Oxygen therapy	217.72	11.01	87	77224	2703	79664374
Acute respiratory failure	210.77	11.01	274	77037	59267	79607810
Completed suicide	210.53	11.01	6	77305	245761	79421316
Toxicity to various agents	198.91	11.01	80	77231	421460	79245617
Concomitant disease aggravated	189.22	11.01	132	77179	13035	79654042
Nasal congestion	185.25	11.01	294	77017	76258	79590819
Oedema peripheral	160.94	11.01	574	76737	251714	79415363
Pulmonary oedema	146.17	11.01	287	77024	87967	79579110
Cough	145.10	11.01	721	76590	366068	79301009
Pulmonary arterial pressure increased	133.43	11.01	72	77239	4483	79662594
Catheter site erythema	126.66	11.01	73	77238	5167	79661910
Oedema	124.17	11.01	323	76988	119257	79547820
Contraindicated product administered	121.27	11.01	8	77303	157530	79509547
Therapeutic product effect decreased	118.63	11.01	11	77300	163852	79503225
Cardiac failure	117.85	11.01	374	76937	154468	79512609
Drug abuse	117.57	11.01	11	77300	162680	79504397
Treatment failure	114.44	11.01	15	77296	170471	79496606
Rheumatoid arthritis	113.18	11.01	31	77280	208439	79458638
Catheter site pruritus	111.06	11.01	51	77260	2240	79664837
Productive cough	110.16	11.01	256	77055	88075	79579002
Brain natriuretic peptide increased	109.05	11.01	81	77230	8819	79658258
Arthropathy	106.73	11.01	21	77290	177090	79489987
Lung transplant	106.16	11.01	62	77249	4499	79662578
Haemoptysis	104.94	11.01	192	77119	55807	79611270
Blood pressure decreased	99.51	11.01	265	77046	99201	79567876
Chest pain	98.40	11.01	536	76775	281768	79385309
Neutropenia	98.03	11.01	81	77230	287629	79379448
Drug intolerance	96.81	11.01	69	77242	264050	79403027
Hypercapnia	95.58	11.01	75	77236	8860	79658217
Alopecia	93.59	11.01	54	77257	231301	79435776
Headache	93.00	11.01	1005	76306	652767	79014310
Catheter management	88.46	11.01	51	77260	3612	79663465
Epistaxis	86.32	11.01	271	77040	111244	79555833
Catheterisation cardiac	83.64	11.01	58	77253	5670	79661407
Respiratory distress	78.19	11.01	174	77137	58165	79608912
Rash	78.01	11.01	293	77018	578065	79089012
Hand deformity	77.88	11.01	6	77305	103913	79563164
Joint swelling	77.14	11.01	100	77211	288546	79378531
Drug hypersensitivity	76.40	11.01	107	77204	298809	79368268
Syncope	75.99	11.01	360	76951	179089	79487988
Cyanosis	71.18	11.01	104	77207	25078	79641999
Thermal burn	69.97	11.01	57	77254	7103	79659974
Glossodynia	69.55	11.01	9	77302	103328	79563749
Scleroderma	69.42	11.01	51	77260	5459	79661618
Pulmonary veno-occlusive disease	68.53	11.01	33	77278	1615	79665462
Catheter site pain	68.11	11.01	50	77261	5346	79661731
Dependence on oxygen therapy	67.40	11.01	24	77287	538	79666539
Intentional overdose	67.21	11.01	11	77300	105949	79561128
Musculoskeletal stiffness	66.39	11.01	44	77267	174964	79492113
Pericarditis	65.71	11.01	11	77300	104225	79562852
Stomatitis	65.66	11.01	30	77281	146727	79520350
Hypotension	64.84	11.01	682	76629	439635	79227442
Catheter site discharge	62.05	11.01	35	77276	2377	79664700
Unevaluable event	61.66	11.01	154	77157	55431	79611646
Hepatic enzyme increased	61.43	11.01	52	77259	182558	79484519
Device alarm issue	61.13	11.01	33	77278	2056	79665021
Air embolism	60.93	11.01	21	77290	426	79666651
Cardiac failure congestive	58.33	11.01	283	77028	142119	79524958
Therapeutic product effect incomplete	57.34	11.01	33	77278	141612	79525465
Flushing	57.16	11.01	202	77109	88066	79579011
Systemic lupus erythematosus	55.40	11.01	24	77287	121125	79545952
Catheter placement	55.27	11.01	35	77276	2939	79664138
Device related infection	54.90	11.01	110	77201	34184	79632893
Chronic respiratory failure	54.75	11.01	35	77276	2987	79664090
Arthralgia	54.56	11.01	328	76983	571475	79095602
Catheter site infection	53.93	11.01	48	77263	6747	79660330
Pleural effusion	53.38	11.01	280	77031	144982	79522095
Pulmonary hypertensive crisis	53.33	11.01	18	77293	342	79666735
Pericardial effusion	52.23	11.01	129	77182	46108	79620969
Emphysema	51.50	11.01	71	77240	16229	79650848
Hypersensitivity	51.38	11.01	111	77200	262128	79404949
Transplant evaluation	50.19	11.01	27	77284	1670	79665407
Off label use	49.80	11.01	602	76709	906613	78760464
Pneumothorax	49.17	11.01	94	77217	28229	79638848
Palpitations	48.57	11.01	247	77064	126363	79540714
Infusion related reaction	48.03	11.01	94	77217	230143	79436934
Intentional product use issue	47.95	11.01	46	77265	152066	79515011
Catheter site rash	47.55	11.01	22	77289	983	79666094
Cor pulmonale	45.44	11.01	28	77283	2240	79664837
Overdose	45.01	11.01	68	77243	184138	79482939
Dizziness	44.89	11.01	738	76573	525703	79141374
Cardiac arrest	44.76	11.01	303	77008	171793	79495284
Discomfort	44.45	11.01	34	77277	125583	79541494
Blood cholesterol increased	44.39	11.01	13	77298	83707	79583370
Condition aggravated	44.02	11.01	706	76605	500418	79166659
Suicide attempt	43.74	11.01	13	77298	82919	79584158
Infusion site pain	43.67	11.01	61	77250	14115	79652962
Dyspnoea at rest	43.48	11.01	44	77267	7258	79659819
Pulmonary congestion	43.47	11.01	87	77224	27013	79640064
Confusional state	42.84	11.01	161	77150	317836	79349241
Helicobacter infection	42.53	11.01	8	77303	69696	79597381
Lung disorder	41.95	11.01	172	77139	80385	79586692
Febrile neutropenia	41.83	11.01	102	77209	230897	79436180
Injection site pain	41.23	11.01	39	77272	129799	79537278
Brain scan abnormal	40.55	11.01	21	77290	1202	79665875
Pulmonary function test decreased	40.06	11.01	43	77268	7594	79659483
Orthopnoea	39.81	11.01	49	77262	10024	79657053
Mobility decreased	39.62	11.01	36	77275	122139	79544938
Anaesthetic complication	39.53	11.01	28	77283	2831	79664246
Cerebral artery thrombosis	39.51	11.01	20	77291	1091	79665986
Respiratory tract infection	38.27	11.01	119	77192	48570	79618507
Pain	38.17	11.01	468	76843	703334	78963743
Cardiac failure acute	38.13	11.01	67	77244	18862	79648215
Nasal dryness	37.74	11.01	33	77278	4530	79662547
Walking distance test abnormal	37.57	11.01	17	77294	721	79666356
Rhinocerebral mucormycosis	37.49	11.01	19	77292	1039	79666038
Pruritus	37.26	11.01	227	77084	394421	79272656
Urticaria	36.59	11.01	78	77233	185123	79481954
Catheter site haemorrhage	36.41	11.01	34	77277	5083	79661994
Death	36.37	11.01	760	76551	565754	79101323
Irritable bowel syndrome	36.20	11.01	8	77303	62233	79604844
Impaired healing	36.07	11.01	20	77291	87635	79579442
Oxygen saturation abnormal	35.63	11.01	32	77279	4550	79662527
Hospitalisation	35.54	11.01	183	77128	94053	79573024
Left ventricular failure	35.30	11.01	45	77266	9536	79657541
Malaise	34.70	11.01	667	76644	489202	79177875
Coma	34.65	11.01	28	77283	100621	79566456
Exercise tolerance decreased	34.05	11.01	43	77268	9028	79658049
Injection site reaction	34.04	11.01	6	77305	54779	79612298
Abdominal pain	33.75	11.01	230	77081	389339	79277738
Device occlusion	33.52	11.01	49	77262	11817	79655260
Chest discomfort	33.50	11.01	239	77072	137805	79529272
Injection site erythema	33.42	11.01	17	77294	78180	79588897
Psoriasis	33.32	11.01	23	77288	89564	79577513
Mucosal inflammation	32.95	11.01	16	77295	75564	79591513
Neuromuscular block prolonged	32.19	11.01	17	77294	1013	79666064
Hypoglycaemia	31.69	11.01	31	77280	101563	79565514
Pulmonary arterial pressure abnormal	31.28	11.01	15	77296	727	79666350
Blister	31.26	11.01	42	77269	119434	79547643
Subcutaneous emphysema	30.59	11.01	20	77291	1774	79665303
Suicidal ideation	30.58	11.01	18	77293	76322	79590755
Pulmonary alveolar haemorrhage	30.48	11.01	46	77265	11411	79655666
Abdominal distension	30.10	11.01	209	77102	119441	79547636
Idiopathic pulmonary fibrosis	29.90	11.01	28	77283	4200	79662877
Catheter removal	29.82	11.01	14	77297	647	79666430
Central venous catheterisation	29.67	11.01	25	77286	3264	79663813
Pulseless electrical activity	29.67	11.01	51	77260	14109	79652968
Leukopenia	29.44	11.01	42	77269	116471	79550606
Wound	29.23	11.01	42	77269	116137	79550940
Interstitial lung disease	29.11	11.01	198	77113	112402	79554675
COVID-19 pneumonia	28.96	11.01	77	77234	28772	79638305
N-terminal prohormone brain natriuretic peptide increased	28.95	11.01	29	77282	4726	79662351
Carbon dioxide increased	28.82	11.01	21	77290	2219	79664858
Malignant neoplasm progression	28.79	11.01	55	77256	135935	79531142
Cardiac ablation	28.72	11.01	21	77290	2232	79664845
Tachypnoea	28.64	11.01	82	77229	31981	79635096
Concomitant disease progression	28.49	11.01	25	77286	3448	79663629
Catheter site scab	28.05	11.01	10	77301	225	79666852
Paracentesis	27.96	11.01	17	77294	1328	79665749
Bronchitis	27.63	11.01	219	77092	130425	79536652
Aspiration pleural cavity	27.50	11.01	18	77293	1599	79665478
Acute kidney injury	27.50	11.01	347	76964	519057	79148020
Cardiac pacemaker insertion	27.45	11.01	31	77280	5791	79661286
Stevens-Johnson syndrome	27.36	11.01	3	77308	39163	79627914
Hyponatraemia	27.35	11.01	85	77226	177763	79489314
Cognitive disorder	27.29	11.01	17	77294	69909	79597168
Aggression	26.85	11.01	8	77303	50950	79616127
Catheter site warmth	26.73	11.01	10	77301	259	79666818
Device connection issue	26.40	11.01	15	77296	1033	79666044
Congestive hepatopathy	26.35	11.01	27	77284	4520	79662557
Osteonecrosis of jaw	26.29	11.01	5	77306	43221	79623856
Atrial flutter	26.20	11.01	62	77249	21563	79645514
Drug interaction	26.04	11.01	267	77044	414916	79252161
Depression	25.89	11.01	115	77196	216675	79450402
Neoplasm progression	25.66	11.01	9	77302	51673	79615404
Neutrophil count decreased	25.64	11.01	32	77279	93927	79573150
Injection site pruritus	25.48	11.01	5	77306	42278	79624799
Drug resistance	25.42	11.01	5	77306	42208	79624869
Neuromuscular blockade	25.29	11.01	12	77299	568	79666509
Catheter site swelling	25.22	11.01	18	77293	1842	79665235
Cardiomegaly	25.12	11.01	69	77242	26283	79640794
Oedematous kidney	25.02	11.01	9	77302	208	79666869
Nocturnal dyspnoea	25.01	11.01	17	77294	1609	79665468
Sputum discoloured	24.91	11.01	61	77250	21682	79645395
Product use in unapproved indication	24.66	11.01	142	77169	250217	79416860
Liver injury	24.65	11.01	12	77299	56602	79610475
Fibromyalgia	24.62	11.01	16	77295	64324	79602753
Red blood cell sedimentation rate increased	24.60	11.01	7	77304	45935	79621142
Atrial fibrillation	24.28	11.01	296	77015	197590	79469487
Heart rate increased	24.25	11.01	200	77111	120524	79546553
Ventilation perfusion mismatch	24.17	11.01	12	77299	628	79666449
Presyncope	24.07	11.01	91	77220	40963	79626114
Hepatitis	23.98	11.01	12	77299	55715	79611362
Hyperthermia malignant	23.93	11.01	21	77290	2896	79664181
Acute right ventricular failure	23.88	11.01	10	77301	351	79666726
Right ventricular dysfunction	23.71	11.01	20	77291	2615	79664462
Tracheostomy	23.71	11.01	15	77296	1257	79665820
Hypertension	23.67	11.01	206	77105	330786	79336291
Peripheral swelling	23.66	11.01	380	76931	269237	79397840
Infusion site infection	23.61	11.01	17	77294	1764	79665313
Accidental underdose	23.51	11.01	13	77298	849	79666228
Pneumomediastinum	23.50	11.01	23	77288	3644	79663433
Oxygen consumption	23.41	11.01	7	77304	88	79666989
Gamma-glutamyltransferase increased	23.33	11.01	110	77201	54570	79612507
Pulmonary haemorrhage	23.31	11.01	47	77264	14670	79652407
Colitis	23.29	11.01	22	77289	73285	79593792
Multiple sclerosis relapse	23.28	11.01	8	77303	46525	79620552
Thrombocytopenia	23.25	11.01	156	77155	265103	79401974
Apnoea	23.02	11.01	41	77270	11663	79655414
Product dose omission issue	22.90	11.01	352	76959	247185	79419892
SARS-CoV-2 viraemia	22.84	11.01	6	77305	45	79667032
Psychotic disorder	22.74	11.01	6	77305	41396	79625681
Catheter site inflammation	22.64	11.01	14	77297	1127	79665950
Rhabdomyolysis	22.46	11.01	41	77270	103090	79563987
Knee arthroplasty	22.41	11.01	7	77304	43241	79623836
Infusion site erythema	22.40	11.01	36	77275	9424	79657653
Agranulocytosis	22.09	11.01	8	77303	45022	79622055
Injection site swelling	22.08	11.01	9	77302	47123	79619954
Tubulointerstitial nephritis	22.06	11.01	5	77306	38230	79628847
Bone marrow failure	22.00	11.01	11	77300	51096	79615981
White blood cell count decreased	21.81	11.01	101	77210	188187	79478890
C-reactive protein increased	21.78	11.01	59	77252	128968	79538109
Rhonchi	21.65	11.01	23	77288	4013	79663064
Rhinorrhoea	21.62	11.01	137	77174	75937	79591140
Catheter site granuloma	21.59	11.01	6	77305	57	79667020
Mediastinal effusion	21.49	11.01	6	77305	58	79667019
Secretion discharge	21.48	11.01	46	77265	14976	79652101
Neuropathy peripheral	21.40	11.01	68	77243	141237	79525840
Device leakage	21.32	11.01	38	77273	10818	79656259
Colitis ulcerative	21.17	11.01	4	77307	34738	79632339
Procedural complication	21.16	11.01	32	77279	7951	79659126
Pulmonary function test abnormal	21.15	11.01	23	77288	4121	79662956
Pulmonary trichosporonosis	21.05	11.01	6	77305	63	79667014
Cold burn	20.99	11.01	4	77307	4	79667073
Cardiac disorder	20.96	11.01	122	77189	65635	79601442
Feeling abnormal	20.79	11.01	241	77070	158958	79508119
Angioplasty	20.71	11.01	16	77295	1847	79665230
Supraventricular tachycardia	20.58	11.01	56	77255	21214	79645863
Therapy non-responder	20.21	11.01	156	77155	92149	79574928
Cytomegalovirus infection	20.21	11.01	8	77303	42636	79624441
Anaesthetic complication cardiac	20.17	11.01	6	77305	74	79667003
Right-to-left cardiac shunt	20.16	11.01	8	77303	244	79666833
Rash maculo-papular	20.06	11.01	15	77296	56063	79611014
PaO2/FiO2 ratio decreased	19.59	11.01	5	77306	33	79667044
Paraesthesia	19.59	11.01	96	77215	176227	79490850
Platelet transfusion	19.50	11.01	17	77294	2325	79664752
Uterine hypotonus	19.47	11.01	6	77305	84	79666993
Respiratory acidosis	19.22	11.01	37	77274	11163	79655914
Decreased activity	19.12	11.01	32	77279	8662	79658415
Pancreatitis	19.08	11.01	23	77288	68552	79598525
Mechanical ventilation	18.97	11.01	18	77293	2746	79664331
Myocardial infarction	18.91	11.01	103	77208	184026	79483051
Exposure during pregnancy	18.81	11.01	44	77267	101088	79565989
Pulmonary artery banding	18.76	11.01	4	77307	10	79667067
Pancreatitis haemorrhagic	18.57	11.01	11	77300	819	79666258
Abdominal cavity drainage	18.57	11.01	11	77300	819	79666258
Mouth ulceration	18.53	11.01	7	77304	38387	79628690
Pulmonary artery dilatation	18.32	11.01	9	77302	460	79666617
Blood alkaline phosphatase increased	18.31	11.01	115	77196	63549	79603528
Emergency care	18.28	11.01	12	77299	1072	79666005
Upper respiratory tract inflammation	18.20	11.01	21	77290	4014	79663063
Aspartate aminotransferase increased	18.15	11.01	210	77101	138431	79528646
Seizure	18.11	11.01	108	77203	188726	79478351
Product use issue	18.08	11.01	124	77187	209698	79457379
Bronchospasm	17.93	11.01	59	77252	24800	79642277
Hallucination	17.87	11.01	35	77276	85710	79581367
Right ventricular enlargement	17.81	11.01	10	77301	673	79666404
Delayed recovery from anaesthesia	17.80	11.01	14	77297	1659	79665418
Eosinophilia	17.73	11.01	11	77300	45334	79621743
Alkalosis hypochloraemic	17.71	11.01	9	77302	495	79666582
Angioedema	17.67	11.01	29	77282	76006	79591071
Acute postoperative sialadenitis	17.58	11.01	5	77306	52	79667025
Areflexia	17.32	11.01	24	77287	5510	79661567
Glossoptosis	17.32	11.01	7	77304	224	79666853
Jugular vein distension	17.17	11.01	13	77298	1457	79665620
Right ventricular systolic pressure increased	17.08	11.01	11	77300	951	79666126
Choking sensation	17.07	11.01	20	77291	3886	79663191
Brain hypoxia	17.07	11.01	11	77300	952	79666125
Rotavirus infection	17.04	11.01	10	77301	732	79666345
Osteoarthritis	17.04	11.01	37	77274	87272	79579805
Lower respiratory tract infection	17.00	11.01	66	77245	129154	79537923
Urine output decreased	16.99	11.01	47	77264	17975	79649102
Iron deficiency anaemia	16.82	11.01	59	77252	25613	79641464
Pulmonary capillary haemangiomatosis	16.78	11.01	5	77306	62	79667015
Ascites	16.71	11.01	128	77183	75434	79591643
Lung assist device therapy	16.62	11.01	6	77305	140	79666937
Bursitis	16.54	11.01	7	77304	35837	79631240
Myotonic dystrophy	16.43	11.01	6	77305	145	79666932
Cerebral haemorrhage	16.41	11.01	19	77292	57654	79609423
Catheter site irritation	16.33	11.01	9	77302	584	79666493
Ventricular tachycardia	16.20	11.01	82	77229	41853	79625224
Joint range of motion decreased	16.18	11.01	6	77305	33276	79633801
Exercise test abnormal	16.16	11.01	5	77306	71	79667006
Argon plasma coagulation	16.14	11.01	4	77307	23	79667054
Inappropriate antidiuretic hormone secretion	16.09	11.01	3	77308	26310	79640767
Dizziness postural	16.09	11.01	35	77276	11514	79655563
Type 2 diabetes mellitus	16.06	11.01	19	77292	57103	79609974
Injection site bruising	15.96	11.01	10	77301	40992	79626085
Complication associated with device	15.87	11.01	45	77266	17451	79649626
Rales	15.82	11.01	49	77262	19952	79647125
Jaundice	15.81	11.01	17	77294	53332	79613745
Device infusion issue	15.68	11.01	15	77296	2311	79664766
Burns third degree	15.53	11.01	8	77303	453	79666624
Thyroglobulin increased	15.50	11.01	5	77306	82	79666995
Procedural hypotension	15.48	11.01	14	77297	2009	79665068
Ill-defined disorder	15.43	11.01	25	77286	65850	79601227
Maternal exposure during pregnancy	15.36	11.01	74	77237	136464	79530613
Cerebral infarction	15.36	11.01	13	77298	45663	79621414
Blood pressure increased	15.34	11.01	131	77180	211229	79455848
Disturbance in attention	15.27	11.01	16	77295	50785	79616292
Diabetic ketoacidosis	15.21	11.01	7	77304	34115	79632962
Emotional distress	15.21	11.01	10	77301	39959	79627118
Poisoning	15.20	11.01	3	77308	25269	79641808
Middle ear effusion	15.20	11.01	15	77296	2400	79664677
Oedematous pancreatitis	15.14	11.01	11	77300	1157	79665920
Head injury	15.09	11.01	74	77237	37295	79629782
Sinus congestion	15.05	11.01	48	77263	19848	79647229
Cardioversion	15.04	11.01	14	77297	2084	79664993
Sinus disorder	15.04	11.01	52	77259	22412	79644665
Oral herpes	15.04	11.01	4	77307	27450	79639627
Cholestasis	15.01	11.01	17	77294	52092	79614985
Inflammation	14.99	11.01	44	77267	93709	79573368
Pneumonia bacterial	14.96	11.01	47	77264	19284	79647793
Multiple allergies	14.92	11.01	32	77279	10428	79656649
Respiratory syncytial virus infection	14.86	11.01	30	77281	9372	79657705
Barotrauma	14.79	11.01	6	77305	194	79666883
Localised oedema	14.55	11.01	27	77284	7925	79659152
Cutaneous mucormycosis	14.48	11.01	6	77305	205	79666872
Palmar-plantar erythrodysaesthesia syndrome	14.46	11.01	7	77304	33127	79633950
Lung infiltration	14.45	11.01	52	77259	22860	79644217
Paradoxical embolism	14.39	11.01	4	77307	38	79667039
Rehabilitation therapy	14.38	11.01	13	77298	1864	79665213
Nasal operation	14.37	11.01	6	77305	209	79666868
Catheter site dermatitis	14.35	11.01	5	77306	105	79666972
Catheter site hypersensitivity	14.21	11.01	5	77306	108	79666969
Cardiorenal syndrome	14.18	11.01	12	77299	1577	79665500
Right ventricular dilatation	14.09	11.01	13	77298	1913	79665164
Blood creatine phosphokinase increased	13.75	11.01	27	77284	66063	79601014
Seasonal allergy	13.73	11.01	41	77270	16365	79650712
Weight increased	13.69	11.01	359	76952	277027	79390050
Airway burns	13.67	11.01	3	77308	9	79667068
Terminal state	13.54	11.01	20	77291	4869	79662208
Pulmonary pain	13.41	11.01	19	77292	4454	79662623
Injury	13.41	11.01	35	77276	77461	79589616
Bradycardia	13.39	11.01	195	77116	135362	79531715
Basal cell carcinoma	13.37	11.01	10	77301	37365	79629712
Hepatocellular injury	13.20	11.01	16	77295	47577	79619500
Therapy interrupted	13.11	11.01	7	77304	31334	79635743
Incorrect dose administered	12.96	11.01	35	77276	76595	79590482
Hospice care	12.94	11.01	30	77281	10294	79656783
Myelosuppression	12.91	11.01	12	77299	40284	79626793
Sedation	12.82	11.01	19	77292	51876	79615201
Blood carbon monoxide increased	12.81	11.01	3	77308	13	79667064
Vena cava filter insertion	12.80	11.01	5	77306	146	79666931
Upper respiratory tract infection	12.79	11.01	140	77171	91028	79576049
Pulmonary thrombosis	12.74	11.01	33	77278	12138	79654939
Gastrointestinal disorder	12.74	11.01	68	77243	122137	79544940
Systemic scleroderma	12.70	11.01	10	77301	1187	79665890
PO2 decreased	12.67	11.01	15	77296	2948	79664129
Rash pruritic	12.66	11.01	32	77279	71597	79595480
Medication error	12.66	11.01	30	77281	68612	79598465
Herpes zoster	12.59	11.01	47	77264	93036	79574041
Thoracic cavity drainage	12.59	11.01	6	77305	287	79666790
Proteinuria	12.55	11.01	8	77303	32494	79634583
Inappropriate schedule of product administration	12.51	11.01	77	77234	133551	79533526
Mastitis bacterial	12.49	11.01	4	77307	64	79667013
Drug level increased	12.48	11.01	12	77299	39639	79627438
Menstrual discomfort	12.46	11.01	3	77308	15	79667062
Pulmonary vein stenosis	12.37	11.01	5	77306	160	79666917
Catheter site erosion	12.32	11.01	4	77307	67	79667010
Gastrointestinal arteriovenous malformation	12.29	11.01	9	77302	959	79666118
Adverse drug reaction	12.25	11.01	29	77282	66363	79600714
Retching	12.19	11.01	41	77270	17426	79649651
Swollen tongue	12.14	11.01	14	77297	42556	79624521
Superinfection fungal	12.10	11.01	4	77307	71	79667006
Frostbite	12.06	11.01	5	77306	171	79666906
Nightmare	12.01	11.01	5	77306	25856	79641221
Haematoma evacuation	12.01	11.01	6	77305	318	79666759
Loss of consciousness	11.96	11.01	229	77082	167714	79499363
Gastrointestinal tube insertion	11.92	11.01	11	77300	1619	79665458
Right ventricular hypertrophy	11.88	11.01	11	77300	1626	79665451
Chronic left ventricular failure	11.82	11.01	9	77302	1017	79666060
Tricuspid valve incompetence	11.81	11.01	44	77267	19668	79647409
Catheter site vesicles	11.76	11.01	6	77305	333	79666744
Oesophageal dilation procedure	11.75	11.01	4	77307	78	79666999
Puncture site infection	11.75	11.01	4	77307	78	79666999
Large intestinal polypectomy	11.74	11.01	6	77305	334	79666743
Right ventricular systolic pressure	11.73	11.01	3	77308	20	79667057
Blood triglycerides increased	11.65	11.01	3	77308	21037	79646040
Intentional product misuse	11.64	11.01	50	77261	95115	79571962
Cardiac septal defect repair	11.60	11.01	3	77308	21	79667056
Lung squamous cell carcinoma stage I	11.60	11.01	3	77308	21	79667056
Sopor	11.59	11.01	9	77302	33001	79634076
Breath sounds abnormal	11.59	11.01	38	77273	15946	79651131
Hypercholesterolaemia	11.50	11.01	4	77307	23091	79643986
Haematocrit decreased	11.47	11.01	100	77211	61212	79605865
Hepatic cytolysis	11.45	11.01	6	77305	27145	79639932
Accident	11.45	11.01	26	77285	8805	79658272
Agonal respiration	11.43	11.01	4	77307	85	79666992
Haemodynamic instability	11.43	11.01	40	77271	17342	79649735
Stress cardiomyopathy	11.41	11.01	30	77281	11136	79655941
Decreased appetite	11.29	11.01	422	76889	341996	79325081
Progressive multifocal leukoencephalopathy	11.29	11.01	3	77308	20597	79646480
Dizziness exertional	11.28	11.01	7	77304	567	79666510
PO2 abnormal	11.25	11.01	3	77308	24	79667053
Withdrawal syndrome	11.23	11.01	6	77305	26848	79640229
Cardiomyopathy	11.22	11.01	7	77304	28767	79638310
Extrapyramidal disorder	11.17	11.01	4	77307	22675	79644402
Diverticulitis	11.17	11.01	17	77294	45919	79621158
Bronchopulmonary aspergillosis	11.13	11.01	47	77264	22247	79644830
Mineral supplementation	11.09	11.01	8	77303	832	79666245
Respiratory disorder	11.07	11.01	78	77233	44778	79622299
Hip arthroplasty	11.04	11.01	11	77300	35745	79631332
Paranasal sinus hypersecretion	11.03	11.01	16	77295	3830	79663247

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AN04	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Medical gases
CHEBI has role	CHEBI:77974	food packaging gases
CHEBI has role	CHEBI:78017	food propellants
CHEBI has role	CHEBI:33937	macronutrients

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Persistent pulmonary hypertension of the newborn	indication	233815004	DOID:13042
Methemoglobinemia	contraindication	38959009	DOID:10783
Left heart failure	contraindication	85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
None (Med Gas)	Air Liquide Industrial U.S. L.P.	2
None (Med Gas)	Air Liquide Large Industries U.S. L.P.	2
None (Med Gas)	Messer LLC	2
None (Med Gas)	Norco Inc.	2
None (Med Gas)	Messer Gas Puerto Rico Inc.	2
None (Med Gas)	Air Liquide America L.P.	2
None (Med Gas)	Airgas Merchant Gases LLC	2
None (Med Gas)	Praxair Inc.	2
None (Med Gas)	Aspen Air, US Corp	2
None (Med Gas)	Air Products and Chemicals Inc.	2
None (Med Gas)	Matheson Tri-Gas Inc.	2
None (Med Gas)	Praxair Canada Inc.	2
None (Med Gas)	Airgas USA LLC	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019163	VUID
N0000147408	NUI
D00083	KEGG_DRUG
4019163	VANDF
C0028158	UMLSCUI
CHEBI:25555	CHEBI
NGN	PDB_CHEM_ID
CHEMBL142438	ChEMBL_ID
D009584	MESH_DESCRIPTOR_UI
DB09152	DRUGBANK_ID
N762921K75	UNII
947	PUBCHEM_CID
7456	RXNORM
002515	NDDF
36012007	SNOMEDCT_US
767123001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10006-005	GAS	99 L	RESPIRATORY (INHALATION)	unapproved medical gas	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10014-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10014-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10018-9502	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10167-400	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10167-400	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10218-102	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10218-102	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10221-002	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10221-002	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10221-002	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10252-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10252-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-200	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-200	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10304-601	GAS	999 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10304-601	GAS	999 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10412-0095	GAS	99.50 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10412-0095	GAS	99.50 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10451-003	GAS	992 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10451-003	GAS	992 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-003	LIQUID	990 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-006	LIQUID	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-006	LIQUID	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-006	LIQUID	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-020	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-021	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-022	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-023	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections