nitrogen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4251 7727-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrogen
  • molecular nitrogen
  • nitrogen gas
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
  • Molecular weight: 28.01
  • Formula: N2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 47.58
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 885.67 11.99 1850 51166 584382 52711668
Pulmonary arterial hypertension 632.51 11.99 372 52644 26750 53269300
Oxygen saturation decreased 585.58 11.99 535 52481 76190 53219860
Pulmonary hypertension 485.36 11.99 355 52661 36915 53259135
Oxygen consumption increased 449.65 11.99 161 52855 3580 53292470
Right ventricular failure 418.99 11.99 241 52775 16602 53279448
Dyspnoea exertional 381.74 11.99 364 52652 54636 53241414
Fluid retention 369.92 11.99 356 52660 54045 53242005
Drug ineffective 293.94 11.99 231 52785 817014 52479036
Hypoxia 283.61 11.99 312 52704 55368 53240682
Chronic obstructive pulmonary disease 283.39 11.99 326 52690 60747 53235303
Respiratory failure 225.69 11.99 378 52638 100134 53195916
Oxygen therapy 215.76 11.99 79 52937 1875 53294175
Rheumatoid arthritis 215.38 11.99 29 52987 314502 52981548
Fluid overload 198.30 11.99 187 52829 27644 53268406
Transfusion 197.83 11.99 139 52877 13548 53282502
Pneumonia 169.78 11.99 826 52190 406343 52889707
Pain in jaw 166.93 11.99 204 52812 40465 53255585
Nasal congestion 163.99 11.99 232 52784 53055 53242995
Oedema peripheral 152.45 11.99 443 52573 170344 53125706
Acute respiratory failure 138.44 11.99 163 52853 31095 53264955
Oedema 124.07 11.99 246 52770 74100 53221950
Cardiac failure 122.12 11.99 266 52750 85578 53210472
Cough 116.86 11.99 535 52481 256358 53039692
Productive cough 112.38 11.99 202 52814 56527 53239523
Toxicity to various agents 108.97 11.99 41 52975 219557 53076493
Pulmonary oedema 108.60 11.99 193 52823 53530 53242520
Pulmonary arterial pressure increased 108.53 11.99 58 52958 3454 53292596
Chest pain 108.11 11.99 424 52592 189761 53106289
Drug hypersensitivity 107.96 11.99 65 52951 265177 53030873
Concomitant disease aggravated 106.38 11.99 80 52936 8658 53287392
Treatment failure 100.42 11.99 7 53009 128396 53167654
Alopecia 93.34 11.99 59 52957 234524 53061526
Catheter site erythema 91.24 11.99 55 52961 4127 53291923
Arthropathy 89.95 11.99 16 53000 141437 53154613
Rash 88.80 11.99 195 52821 445996 52850054
Catheter site pruritus 87.66 11.99 42 52974 1982 53294068
Epistaxis 86.64 11.99 203 52813 68507 53227543
Therapeutic product effect decreased 84.88 11.99 12 53004 125643 53170407
Drug intolerance 79.94 11.99 53 52963 205440 53090610
Joint swelling 78.00 11.99 71 52945 234567 53061483
Glossodynia 76.89 11.99 6 53010 100285 53195765
Catheter management 76.79 11.99 43 52973 2809 53293241
Haemoptysis 75.96 11.99 115 52901 27924 53268126
Headache 75.27 11.99 839 52177 535982 52760068
Neutropenia 75.20 11.99 32 52984 159153 53136897
Syncope 73.83 11.99 262 52754 111731 53184319
Scleroderma 72.07 11.99 51 52965 5024 53291026
Lung transplant 71.66 11.99 42 52974 2992 53293058
Hand deformity 71.37 11.99 3 53013 84846 53211204
Blood pressure decreased 68.61 11.99 174 52842 61695 53234355
Dependence on oxygen therapy 68.45 11.99 22 52994 347 53295703
Brain natriuretic peptide increased 66.50 11.99 48 52968 4877 53291173
Systemic lupus erythematosus 66.34 11.99 21 52995 125393 53170657
Catheterisation cardiac 63.69 11.99 44 52972 4170 53291880
Hypercapnia 61.14 11.99 46 52970 4981 53291069
Cardiac failure congestive 60.26 11.99 216 52800 92541 53203509
Musculoskeletal stiffness 59.55 11.99 24 52992 123344 53172706
Device alarm issue 57.71 11.99 29 52987 1519 53294531
Hypotension 53.89 11.99 434 52582 253642 53042408
Arthralgia 52.36 11.99 242 52774 439541 52856509
Catheter site pain 51.77 11.99 38 52978 3963 53292087
Off label use 50.96 11.99 269 52747 471943 52824107
Cyanosis 50.49 11.99 72 52944 16567 53279483
Drug abuse 49.99 11.99 4 53012 65522 53230528
Palpitations 49.27 11.99 217 52799 102131 53193919
Dizziness 48.94 11.99 575 52441 371684 52924366
Pleural effusion 48.23 11.99 195 52821 88384 53207666
Cor pulmonale 48.19 11.99 28 52988 1962 53294088
Flushing 48.08 11.99 167 52849 70433 53225617
Pericardial effusion 47.57 11.99 92 52924 27186 53268864
Unevaluable event 46.57 11.99 131 52885 49367 53246683
Injection site erythema 46.43 11.99 10 53006 77239 53218811
Condition aggravated 46.40 11.99 475 52541 296659 52999391
Maternal exposure during pregnancy 46.09 11.99 52 52964 155587 53140463
Catheter site discharge 45.26 11.99 27 52989 1987 53294063
Malaise 45.06 11.99 548 52468 357069 52938981
Dyspnoea at rest 43.67 11.99 34 52982 3873 53292177
Device related infection 43.65 11.99 80 52936 22706 53273344
Pulmonary veno-occlusive disease 43.51 11.99 21 52995 1007 53295043
Suicide attempt 43.15 11.99 4 53012 58164 53237886
Stomatitis 42.84 11.99 22 52994 98136 53197914
Hypersensitivity 42.67 11.99 91 52925 210574 53085476
Exercise tolerance decreased 42.40 11.99 38 52978 5257 53290793
Transplant evaluation 42.34 11.99 21 52995 1069 53294981
Psoriasis 41.92 11.99 17 52999 87072 53208978
Intentional overdose 41.84 11.99 8 53008 67197 53228853
Injection site pain 41.74 11.99 31 52985 113360 53182690
Pruritus 41.61 11.99 151 52865 293681 53002369
Infusion related reaction 41.06 11.99 57 52959 155900 53140150
Hepatic enzyme increased 40.93 11.99 39 52977 126156 53169894
Pain 40.92 11.99 381 52635 588017 52708033
Catheter site infection 40.32 11.99 36 52980 4956 53291094
Chronic respiratory failure 40.16 11.99 24 52992 1772 53294278
Orthopnoea 39.65 11.99 39 52977 6065 53289985
Lung disorder 39.57 11.99 121 52895 47758 53248292
Discomfort 39.33 11.99 23 52993 95449 53200601
Catheter site rash 38.87 11.99 18 52998 786 53295264
Therapeutic product effect incomplete 37.97 11.99 22 52994 91762 53204288
Chest discomfort 37.57 11.99 197 52819 99498 53196552
Pulmonary hypertensive crisis 37.35 11.99 12 53004 189 53295861
Pulmonary arterial pressure abnormal 36.90 11.99 15 53001 475 53295575
Psoriatic arthropathy 36.60 11.99 3 53013 48187 53247863
Left ventricular failure 36.38 11.99 35 52981 5298 53290752
Hospitalisation 36.03 11.99 153 52863 70859 53225191
Infusion site pain 35.60 11.99 51 52965 11782 53284268
Pericarditis 33.66 11.99 11 53005 64395 53231655
Respiratory distress 33.27 11.99 91 52925 33736 53262314
Overdose 32.98 11.99 35 52981 107701 53188349
Presyncope 32.56 11.99 77 52939 26117 53269933
Exposure during pregnancy 32.49 11.99 46 52970 124814 53171236
Aspiration pleural cavity 32.49 11.99 16 53000 802 53295248
Nasal dryness 32.34 11.99 28 52988 3701 53292349
Injection site reaction 32.04 11.99 6 53010 51160 53244890
Oxygen consumption 31.39 11.99 9 53007 94 53295956
Thermal burn 31.35 11.99 32 52984 5201 53290849
Wound 31.22 11.99 27 52989 91530 53204520
Febrile neutropenia 31.12 11.99 35 52981 104901 53191149
Abdominal distension 30.98 11.99 159 52857 79631 53216419
Air embolism 30.86 11.99 11 53005 241 53295809
Urticaria 30.70 11.99 55 52961 135830 53160220
Death 30.36 11.99 511 52505 356721 52939329
Product use issue 30.20 11.99 58 52958 139526 53156524
Oxygen saturation abnormal 30.04 11.99 24 52992 2838 53293212
Bronchitis 29.86 11.99 202 52814 111697 53184353
Catheter placement 29.71 11.99 21 52995 2064 53293986
Cardiac pacemaker insertion 29.67 11.99 27 52989 3810 53292240
Central venous catheterisation 29.39 11.99 21 52995 2100 53293950
Leukopenia 28.46 11.99 19 52997 73444 53222606
Pulmonary congestion 27.57 11.99 54 52962 16102 53279948
Device leakage 27.39 11.99 32 52984 6048 53290002
Suicidal ideation 27.24 11.99 13 53003 60498 53235552
Paracentesis 27.22 11.99 15 53001 949 53295101
Emphysema 27.18 11.99 41 52975 9918 53286132
Impaired healing 27.11 11.99 15 53001 64190 53231860
Cardiac disorder 26.03 11.99 104 52912 46862 53249188
Depression 25.92 11.99 94 52922 182958 53113092
Cardiac failure acute 25.63 11.99 38 52978 9054 53286996
Atrial flutter 25.49 11.99 39 52977 9552 53286498
Ascites 25.33 11.99 92 52924 39643 53256407
Cardiac ablation 25.29 11.99 16 53000 1308 53294742
Blister 24.76 11.99 25 52991 78728 53217322
Device occlusion 24.66 11.99 32 52984 6733 53289317
Rales 24.60 11.99 41 52975 10791 53285259
Blood cholesterol increased 24.45 11.99 11 53005 52978 53243072
N-terminal prohormone brain natriuretic peptide increased 24.44 11.99 18 52998 1886 53294164
Injection site pruritus 23.76 11.99 6 53010 41583 53254467
Bladder agenesis 23.56 11.99 8 53008 151 53295899
Blood iron decreased 23.50 11.99 43 52973 12185 53283865
Gamma-glutamyltransferase increased 23.37 11.99 80 52936 33475 53262575
Cloacal exstrophy 23.17 11.99 8 53008 159 53295891
Congenital ectopic bladder 23.09 11.99 7 53009 90 53295960
Genitalia external ambiguous 22.89 11.99 8 53008 165 53295885
Walking distance test abnormal 22.51 11.99 11 53005 542 53295508
Rhinorrhoea 22.37 11.99 109 52907 53469 53242581
Interstitial lung disease 22.18 11.99 116 52900 58506 53237544
Catheter site scab 22.08 11.99 8 53008 184 53295866
Cardiac arrest 22.02 11.99 164 52852 93503 53202547
Therapy non-responder 22.01 11.99 102 52914 49018 53247032
Wheezing 21.90 11.99 125 52891 65150 53230900
Irritable bowel syndrome 21.85 11.99 8 53008 43624 53252426
Anaesthetic complication 21.83 11.99 17 52999 1937 53294113
Catheter site swelling 21.75 11.99 15 53001 1417 53294633
Meconium stain 21.64 11.99 8 53008 195 53295855
Congestive hepatopathy 21.15 11.99 19 52997 2637 53293413
Disease progression 20.95 11.99 173 52843 101747 53194303
Gastrointestinal disorder congenital 20.92 11.99 7 53009 126 53295924
Neuromuscular blockade 20.78 11.99 9 53007 335 53295715
Pulmonary function test decreased 20.61 11.99 23 52993 4138 53291912
Heart rate increased 20.42 11.99 146 52870 82169 53213881
Respiratory tract infection 20.40 11.99 76 52940 33148 53262902
Nocturnal dyspnoea 20.30 11.99 13 53003 1085 53294965
Haematocrit decreased 20.16 11.99 82 52934 37249 53258801
Tethered cord syndrome 20.12 11.99 8 53008 239 53295811
Concomitant disease progression 19.94 11.99 17 52999 2201 53293849
Congenital genital malformation 19.91 11.99 7 53009 147 53295903
Sputum discoloured 19.87 11.99 44 52972 14295 53281755
Lipodystrophy acquired 19.84 11.99 15 53001 1635 53294415
Stent placement 19.81 11.99 21 52995 3566 53292484
Haemoglobin decreased 19.72 11.99 216 52800 137091 53158959
Multiple sclerosis relapse 19.64 11.99 10 53006 44843 53251207
Cognitive disorder 19.58 11.99 10 53006 44768 53251282
Injection site swelling 19.43 11.99 9 53007 42619 53253431
Device connection issue 19.19 11.99 11 53005 751 53295299
Osteonecrosis of jaw 19.19 11.99 6 53010 36140 53259910
Coma 18.98 11.99 20 52996 61763 53234287
Knee arthroplasty 18.88 11.99 5 53011 33564 53262486
Gastrointestinal malformation 18.70 11.99 7 53009 177 53295873
Iron deficiency anaemia 18.28 11.99 50 52966 18530 53277520
Infusion site infection 18.23 11.99 14 53002 1563 53294487
Neuropathy peripheral 18.14 11.99 48 52968 103139 53192911
Mobility decreased 18.01 11.99 30 52986 76241 53219809
Hyperandrogenism 17.98 11.99 6 53010 107 53295943
Malignant neoplasm progression 17.97 11.99 27 52989 71514 53224536
Subcutaneous emphysema 17.90 11.99 11 53005 854 53295196
Paraesthesia 17.70 11.99 66 52950 127449 53168601
Localised oedema 17.64 11.99 24 52992 5285 53290765
Pulmonary pain 17.47 11.99 16 53000 2276 53293774
Ventilation perfusion mismatch 17.15 11.99 7 53009 224 53295826
Hypoglycaemia 17.14 11.99 20 52996 58993 53237057
Atrial fibrillation 17.13 11.99 178 52838 111474 53184576
Gout 17.13 11.99 38 52978 12361 53283689
Uterine hypotonus 16.94 11.99 6 53010 129 53295921
Infusion site erythema 16.93 11.99 31 52985 8791 53287259
Platelet transfusion 16.80 11.99 10 53006 733 53295317
Cardioversion 16.78 11.99 12 53004 1201 53294849
Anencephaly 16.78 11.99 7 53009 237 53295813
Oxygen consumption decreased 16.59 11.99 7 53009 244 53295806
Right ventricular systolic pressure increased 16.58 11.99 9 53007 553 53295497
Breath sounds abnormal 16.53 11.99 30 52986 8447 53287603
Argon plasma coagulation 16.35 11.99 4 53012 21 53296029
Enlarged clitoris 16.24 11.99 6 53010 146 53295904
Blood pressure increased 16.24 11.99 78 52938 140401 53155649
Idiopathic pulmonary fibrosis 16.21 11.99 13 53003 1545 53294505
Lung assist device therapy 16.17 11.99 5 53011 69 53295981
Rhabdomyolysis 16.16 11.99 12 53004 43911 53252139
Red blood cell sedimentation rate increased 16.12 11.99 4 53012 28053 53267997
Abdominal cavity drainage 16.12 11.99 8 53008 408 53295642
Anal atresia 16.08 11.99 8 53008 410 53295640
Drug interaction 16.04 11.99 140 52876 219189 53076861
Bone marrow failure 15.99 11.99 5 53011 30110 53265940
Tracheostomy 15.94 11.99 9 53007 597 53295453
Acute postoperative sialadenitis 15.90 11.99 4 53012 24 53296026
Aspartate aminotransferase increased 15.88 11.99 140 52876 83889 53212161
Right ventricular dysfunction 15.77 11.99 13 53003 1606 53294444
Adverse drug reaction 15.77 11.99 18 52998 53607 53242443
Cold burn 15.67 11.99 3 53013 3 53296047
Pulmonary capillary haemangiomatosis 15.63 11.99 4 53012 26 53296024
Osteoarthritis 15.49 11.99 29 52987 70457 53225593
Anaemia 15.48 11.99 372 52644 276346 53019704
Accident 15.45 11.99 23 52993 5498 53290552
Pulmonary haemorrhage 15.42 11.99 26 52990 6907 53289143
Caudal regression syndrome 15.39 11.99 6 53010 170 53295880
Rehabilitation therapy 15.26 11.99 12 53004 1386 53294664
Hyponatraemia 15.21 11.99 56 52960 108551 53187499
Ill-defined disorder 15.19 11.99 16 53000 49428 53246622
Echocardiogram 15.13 11.99 4 53012 30 53296020
Terminal state 15.10 11.99 15 53001 2361 53293689
Confusional state 15.09 11.99 122 52894 194099 53101951
Jugular vein distension 15.07 11.99 10 53006 887 53295163
Peripheral swelling 15.04 11.99 288 52728 205820 53090230
Spine malformation 15.00 11.99 7 53009 311 53295739
Hospice care 15.00 11.99 24 52992 6106 53289944
Tachypnoea 14.94 11.99 42 52974 15812 53280238
Middle ear effusion 14.76 11.99 14 53002 2081 53293969
Bronchospasm 14.70 11.99 43 52973 16555 53279495
Catheter site inflammation 14.59 11.99 9 53007 704 53295346
Supraventricular tachycardia 14.55 11.99 39 52977 14286 53281764
Rhonchi 14.53 11.99 15 53001 2471 53293579
Upper respiratory tract inflammation 14.43 11.99 16 53000 2858 53293192
Carbon dioxide increased 14.27 11.99 11 53005 1235 53294815
Injection site bruising 14.22 11.99 10 53006 37636 53258414
Right ventricular dilatation 14.22 11.99 10 53006 975 53295075
Catheter site warmth 14.15 11.99 6 53010 212 53295838
Catheter site haemorrhage 14.06 11.99 16 53000 2939 53293111
Lower respiratory tract infection 14.04 11.99 45 52971 90936 53205114
Rash maculo-papular 14 11.99 6 53010 29743 53266307
PO2 decreased 13.93 11.99 12 53004 1575 53294475
Pulmonary artery banding 13.86 11.99 3 53013 8 53296042
Paradoxical embolism 13.85 11.99 4 53012 43 53296007
Neural tube defect 13.84 11.99 6 53010 224 53295826
Catheter site hypersensitivity 13.80 11.99 5 53011 115 53295935
Cardiomegaly 13.79 11.99 44 52972 17756 53278294
Seizure 13.78 11.99 74 52942 129435 53166615
Meningomyelocele 13.70 11.99 8 53008 566 53295484
Angioedema 13.63 11.99 13 53003 42063 53253987
Red blood cell count decreased 13.55 11.99 71 52945 35832 53260218
Pulmonary artery dilatation 13.54 11.99 6 53010 236 53295814
Upper respiratory tract infection 13.51 11.99 116 52900 68981 53227069
Gastrointestinal arteriovenous malformation 13.44 11.99 8 53008 586 53295464
Dizziness exertional 13.27 11.99 7 53009 406 53295644
Product use in unapproved indication 13.18 11.99 62 52954 112227 53183823
C-reactive protein increased 13.16 11.99 30 52986 67856 53228194
Biopsy liver 13.14 11.99 7 53009 414 53295636
Pulmonary fibrosis 13.02 11.99 53 52963 24082 53271968
Urinary retention 12.99 11.99 6 53010 28460 53267590
Mucosal inflammation 12.97 11.99 14 53002 42770 53253280
Pneumonia bacterial 12.90 11.99 26 52990 7914 53288136
Diverticulitis 12.89 11.99 10 53006 35791 53260259
Neutrophil count decreased 12.85 11.99 18 52998 49080 53246970
Increased bronchial secretion 12.84 11.99 12 53004 1751 53294299
Umbilical cord abnormality 12.76 11.99 8 53008 644 53295406
Polypectomy 12.74 11.99 8 53008 645 53295405
Frostbite 12.74 11.99 3 53013 13 53296037
Product dose omission issue 12.72 11.99 264 52752 191356 53104694
Hepatocellular injury 12.66 11.99 7 53009 29979 53266071
Neoplasm progression 12.61 11.99 7 53009 29912 53266138
Emergency care 12.60 11.99 9 53007 899 53295151
Hepatic function abnormal 12.59 11.99 71 52945 36828 53259222
Therapy change 12.59 11.99 21 52995 5531 53290519
Herpes zoster 12.58 11.99 35 52981 73984 53222066
Vascular cauterisation 12.57 11.99 4 53012 61 53295989
Hypozincaemia 12.56 11.99 3 53013 14 53296036
Hepatotoxicity 12.53 11.99 6 53010 27874 53268176
Glossoptosis 12.39 11.99 4 53012 64 53295986
Menstrual discomfort 12.39 11.99 3 53013 15 53296035
Lung squamous cell carcinoma stage I 12.39 11.99 3 53013 15 53296035
Pregnancy 12.35 11.99 8 53008 31433 53264617
Packed red blood cell transfusion 12.35 11.99 13 53003 2190 53293860
Systemic scleroderma 12.28 11.99 9 53007 936 53295114
Continuous positive airway pressure 12.28 11.99 4 53012 66 53295984
Aggression 12.22 11.99 4 53012 23399 53272651
Sepsis neonatal 12.19 11.99 7 53009 480 53295570
Mouth ulceration 12.16 11.99 7 53009 29319 53266731
Abdominal pain 12.15 11.99 180 52836 255723 53040327
Congenital musculoskeletal anomaly 12.13 11.99 7 53009 484 53295566
Wrong technique in product usage process 12.07 11.99 26 52990 60006 53236044
Right ventricular hypertrophy 12.03 11.99 8 53008 712 53295338

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 373.35 12.99 854 24798 361191 32126683
Oxygen saturation decreased 328.78 12.99 285 25367 47814 32440060
Pulmonary arterial hypertension 282.00 12.99 143 25509 9678 32478196
Hypoxia 202.57 12.99 227 25425 51905 32435969
Right ventricular failure 202.28 12.99 109 25543 8354 32479520
Chronic obstructive pulmonary disease 170.35 12.99 201 25451 48552 32439322
Oxygen consumption increased 170.33 12.99 57 25595 1309 32486565
Pulmonary hypertension 167.94 12.99 135 25517 20359 32467515
Fluid retention 115.88 12.99 123 25529 26427 32461447
Respiratory failure 112.71 12.99 256 25396 106926 32380948
Concomitant disease aggravated 111.01 12.99 64 25588 5589 32482285
Acute respiratory failure 101.18 12.99 119 25533 28609 32459265
Pneumonia 92.43 12.99 535 25117 354717 32133157
Dyspnoea exertional 88.39 12.99 130 25522 38831 32449043
Transfusion 69.68 12.99 54 25598 7714 32480160
Oxygen therapy 68.84 12.99 25 25627 736 32487138
Pain in jaw 65.07 12.99 64 25588 12562 32475312
Toxicity to various agents 57.05 12.99 35 25617 178006 32309868
Nasal congestion 53.67 12.99 73 25579 20278 32467596
Thermal burn 50.04 12.99 29 25623 2556 32485318
Completed suicide 49.67 12.99 7 25645 92510 32395364
Fluid overload 49.66 12.99 69 25583 19552 32468322
Pulmonary oedema 49.06 12.99 111 25541 46156 32441718
Respiratory distress 47.17 12.99 93 25559 35153 32452721
Cerebral artery thrombosis 46.70 12.99 18 25634 627 32487247
Cough 45.34 12.99 223 25429 138594 32349280
Pulmonary arterial pressure increased 45.26 12.99 21 25631 1166 32486708
Idiopathic pulmonary fibrosis 44.84 12.99 33 25619 4362 32483512
Brain natriuretic peptide increased 40.99 12.99 31 25621 4269 32483605
Brain scan abnormal 40.60 12.99 17 25635 737 32487137
Drug abuse 38.82 12.99 8 25644 80235 32407639
Condition aggravated 38.62 12.99 232 25420 155429 32332445
Hypercapnia 37.64 12.99 29 25623 4106 32483768
Oedema 35.87 12.99 97 25555 45050 32442824
Catheter site erythema 35.36 12.99 18 25634 1225 32486649
Lung transplant 32.56 12.99 20 25632 1960 32485914
Blood pressure decreased 32.17 12.99 101 25551 50979 32436895
Catheter management 31.76 12.99 15 25637 867 32487007
Cor pulmonale 30.69 12.99 14 25638 747 32487127
Neutropenia 29.01 12.99 42 25610 142133 32345741
Chronic respiratory failure 28.41 12.99 16 25636 1335 32486539
Drug ineffective 28.34 12.99 182 25470 383295 32104579
Neuromuscular block prolonged 26.96 12.99 11 25641 446 32487428
Pulmonary function test abnormal 26.71 12.99 18 25634 2068 32485806
Haemoptysis 26.59 12.99 72 25580 33453 32454421
Oedema peripheral 26.34 12.99 167 25485 113924 32373950
Cardiac failure 26.22 12.99 142 25510 91531 32396343
Mechanical ventilation 25.99 12.99 17 25635 1858 32486016
Areflexia 25.80 12.99 20 25632 2856 32485018
Rheumatoid arthritis 24.78 12.99 3 25649 44541 32443333
Catheter removal 23.69 12.99 8 25644 189 32487685
Accident 23.32 12.99 22 25630 4100 32483774
Catheterisation cardiac 23.25 12.99 17 25635 2224 32485650
Pneumothorax 23.06 12.99 46 25606 17524 32470350
Catheter site haemorrhage 23.02 12.99 17 25635 2258 32485616
Cyanosis 23.02 12.99 38 25614 12515 32475359
Pulmonary veno-occlusive disease 22.74 12.99 10 25642 489 32487385
Rotavirus infection 22.63 12.99 9 25643 341 32487533
Lung disorder 22.41 12.99 68 25584 33686 32454188
Emphysema 22.38 12.99 33 25619 9864 32478010
Transplant evaluation 22.13 12.99 10 25642 522 32487352
Catheter placement 21.90 12.99 11 25641 728 32487146
Catheter site pain 21.89 12.99 13 25639 1199 32486675
Air embolism 21.37 12.99 7 25645 150 32487724
Subacute combined cord degeneration 21.11 12.99 7 25645 156 32487718
Catheter site discharge 21.08 12.99 10 25642 584 32487290
Carbon dioxide increased 20.86 12.99 12 25640 1043 32486831
Hyperthermia malignant 20.64 12.99 15 25637 1944 32485930
Pulmonary fibrosis 20.57 12.99 43 25609 16931 32470943
Anaesthetic complication 20.44 12.99 12 25640 1083 32486791
Catheter site granuloma 20.24 12.99 5 25647 36 32487838
Cardiac arrest 20.11 12.99 138 25514 96638 32391236
Catheter site pruritus 20.00 12.99 8 25644 308 32487566
Aggression 18.89 12.99 4 25648 39385 32448489
Catheter site warmth 18.52 12.99 5 25647 53 32487821
Intentional overdose 18.43 12.99 5 25647 41596 32446278
Respiratory acidosis 18.40 12.99 20 25632 4408 32483466
Pulmonary function test decreased 18.15 12.99 21 25631 4954 32482920
Accidental underdose 18.10 12.99 8 25644 396 32487478
Ventilation perfusion mismatch 17.24 12.99 5 25647 70 32487804
Burns third degree 17.04 12.99 6 25646 161 32487713
Cardiac failure congestive 17.03 12.99 120 25532 84732 32403142
Infusion site vesicles 16.91 12.99 6 25646 165 32487709
Walking distance test abnormal 16.84 12.99 6 25646 167 32487707
Pulmonary hypertensive crisis 16.80 12.99 6 25646 168 32487706
Headache 16.79 12.99 232 25420 195965 32291909
Acute kidney injury 16.55 12.99 150 25502 293318 32194556
Leukopenia 16.37 12.99 14 25638 60108 32427766
Suicide attempt 16.20 12.99 5 25647 38239 32449635
Pulse pressure decreased 16.17 12.99 6 25646 188 32487686
Anaesthetic complication cardiac 16.05 12.99 4 25648 30 32487844
Thoracic cavity drainage 15.93 12.99 6 25646 196 32487678
Hypocapnia 15.90 12.99 6 25646 197 32487677
Drug interaction 15.82 12.99 104 25548 218081 32269793
Pulmonary capillary haemangiomatosis 15.82 12.99 4 25648 32 32487842
PaO2/FiO2 ratio decreased 15.71 12.99 4 25648 33 32487841
Epistaxis 15.60 12.99 86 25566 55769 32432105
Ventricular tachycardia 15.59 12.99 50 25602 25506 32462368
Interstitial lung disease 15.51 12.99 96 25556 64905 32422969
Pulmonary congestion 15.50 12.99 33 25619 13158 32474716
Bradycardia 15.43 12.99 103 25549 71459 32416415
Dyspnoea at rest 15.42 12.99 16 25636 3343 32484531
Burns second degree 15.39 12.99 7 25645 371 32487503
Hyponatraemia 15.19 12.99 22 25630 74491 32413383
Treatment failure 15.08 12.99 6 25646 39157 32448717
Confusional state 15.03 12.99 60 25592 143055 32344819
Abdominal pain 14.89 12.99 64 25588 149465 32338409
White blood cell count decreased 14.88 12.99 31 25621 91167 32396707
Complication associated with device 14.83 12.99 21 25631 6051 32481823
Apnoea 14.56 12.99 22 25630 6721 32481153
Catheter site inflammation 14.46 12.99 6 25646 254 32487620
Barotrauma 14.07 12.99 4 25648 52 32487822
Productive cough 13.46 12.99 58 25594 34058 32453816
Therapeutic product effect incomplete 13.39 12.99 8 25644 41333 32446541
Thrombocytopenia 13.27 12.99 66 25586 148233 32339641
Myocardial infarction 13.00 12.99 53 25599 125623 32362251

Pharmacologic Action:

SourceCodeDescription
ATC V03AN04 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:33937 macronutrients

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Persistent pulmonary hypertension of the newborn indication 233815004 DOID:13042
Methemoglobinemia contraindication 38959009 DOID:10783
Left heart failure contraindication 85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019163 VUID
N0000147408 NUI
D00083 KEGG_DRUG
4019163 VANDF
C0028158 UMLSCUI
CHEBI:25555 CHEBI
HDZ PDB_CHEM_ID
TFH PDB_CHEM_ID
CHEMBL142438 ChEMBL_ID
D009584 MESH_DESCRIPTOR_UI
DB09152 DRUGBANK_ID
N762921K75 UNII
947 PUBCHEM_CID
7456 RXNORM
002515 NDDF
36012007 SNOMEDCT_US
767123001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10006-005 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10018-9502 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-003 LIQUID 990 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-020 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-021 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-022 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-023 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10678-002 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10690-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10698-0002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10736-002 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
COMPRESSED GAS N.O.S. HUMAN PRESCRIPTION DRUG LABEL 3 10736-011 GAS 75.05 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10825-003 GAS 90 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10913-010 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-101 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-106 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2000 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2010 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 11023-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections