nitrogen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4251	7727-37-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nitrogen molecular nitrogen nitrogen gas nitrogen, nf	An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells. Molecular weight: 28.01 Formula: N2 CLOGP: LIPINSKI: None HAC: 2 HDO: 0 TPSA: 47.58 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

nitrogen
molecular nitrogen
nitrogen gas
nitrogen, nf

An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.

Molecular weight: 28.01
Formula: N2
CLOGP:
LIPINSKI: None
HAC: 2
HDO: 0
TPSA: 47.58
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	939.53	11.76	1917	54481	590660	55645009
Pulmonary arterial hypertension	674.91	11.76	386	56012	26117	56209552
Oxygen saturation decreased	606.70	11.76	555	55843	78512	56157157
Pulmonary hypertension	519.66	11.76	366	56032	35578	56200091
Oxygen consumption increased	468.27	11.76	165	56233	3466	56232203
Right ventricular failure	445.06	11.76	249	56149	16130	56219539
Dyspnoea exertional	400.05	11.76	374	56024	54315	56181354
Fluid retention	386.31	11.76	365	56033	53713	56181956
Drug ineffective	351.47	11.76	248	56150	918741	55316928
Chronic obstructive pulmonary disease	325.90	11.76	342	56056	57073	56178596
Hypoxia	316.59	11.76	327	56071	53570	56182099
Rheumatoid arthritis	275.47	11.76	31	56367	382573	55853096
Respiratory failure	272.98	11.76	402	55996	94660	56141009
Hypervolaemia	218.90	11.76	194	56204	26264	56209405
Oxygen therapy	216.36	11.76	79	56319	1844	56233825
Pneumonia	206.57	11.76	880	55518	406218	55829451
Transfusion	205.36	11.76	142	56256	13378	56222291
Pain in jaw	174.70	11.76	208	56190	39828	56195841
Nasal congestion	166.92	11.76	242	56156	56128	56179541
Oedema peripheral	160.06	11.76	454	55944	170800	56064869
Acute respiratory failure	153.66	11.76	172	56226	30822	56204847
Arthropathy	141.99	11.76	17	56381	200258	56035411
Treatment failure	141.59	11.76	7	56391	170385	56065284
Cardiac failure	139.51	11.76	275	56123	81818	56153851
Alopecia	139.14	11.76	60	56338	293398	55942271
Cough	136.17	11.76	568	55830	259393	55976276
Productive cough	129.51	11.76	215	56183	56017	56179652
Glossodynia	127.51	11.76	6	56392	152452	56083217
Therapeutic product effect decreased	126.20	11.76	12	56386	169440	56066229
Drug intolerance	124.16	11.76	55	56343	264763	55970906
Chest pain	117.32	11.76	437	55961	189360	56046309
Pulmonary oedema	117.04	11.76	195	56203	50948	56184721
Joint swelling	116.98	11.76	73	56325	289727	55945942
Hand deformity	116.83	11.76	4	56394	134488	56101181
Pulmonary arterial pressure increased	115.47	11.76	60	56338	3345	56232324
Rash	111.21	11.76	203	56195	492844	55742825
Toxicity to various agents	111.12	11.76	43	56355	224521	56011148
Oedema	110.78	11.76	250	56148	81670	56153999
Concomitant disease aggravated	110.65	11.76	81	56317	8345	56227324
Systemic lupus erythematosus	110.26	11.76	23	56375	180055	56055614
Drug hypersensitivity	108.77	11.76	71	56327	275134	55960535
Epistaxis	94.50	11.76	208	56190	66815	56168854
Catheter site erythema	92.20	11.76	55	56343	4015	56231654
Catheter site pruritus	90.62	11.76	43	56355	1969	56233700
Haemoptysis	84.43	11.76	118	56280	26442	56209227
Syncope	84.12	11.76	269	56129	107930	56127739
Lung transplant	83.28	11.76	46	56352	2901	56232768
Musculoskeletal stiffness	80.30	11.76	28	56370	155979	56079690
Hypercapnia	78.49	11.76	54	56344	5042	56230627
Blood pressure decreased	77.36	11.76	178	56220	58872	56176797
Catheter management	76.83	11.76	43	56355	2783	56232886
Discomfort	75.48	11.76	24	56374	141737	56093932
Headache	75.44	11.76	873	55525	558171	55677498
Brain natriuretic peptide increased	74.97	11.76	51	56347	4675	56230994
Hepatic enzyme increased	73.58	11.76	40	56358	171344	56064325
Pericarditis	72.97	11.76	11	56387	108912	56126757
Cardiac failure congestive	72.69	11.76	223	56175	87497	56148172
Dependence on oxygen therapy	72.44	11.76	23	56375	345	56235324
Scleroderma	72.37	11.76	51	56347	4950	56230719
Arthralgia	70.44	11.76	262	56136	501407	55734262
Hypersensitivity	66.63	11.76	96	56302	256312	55979357
Wound	66.30	11.76	28	56370	138776	56096893
Hypotension	65.85	11.76	453	55945	250055	55985614
Off label use	65.40	11.76	311	56087	555869	55679800
Infusion related reaction	62.82	11.76	70	56328	208861	56026808
Catheterisation cardiac	62.80	11.76	44	56354	4231	56231438
Psoriatic arthropathy	61.57	11.76	3	56395	74005	56161664
Maternal exposure during pregnancy	60.93	11.76	60	56338	189493	56046176
Stomatitis	59.93	11.76	23	56375	120787	56114882
Device alarm issue	59.84	11.76	29	56369	1392	56234277
Pain	59.04	11.76	406	55992	662778	55572891
Product use issue	58.52	11.76	60	56338	185981	56049688
Pleural effusion	57.96	11.76	203	56195	85277	56150392
Palpitations	57.77	11.76	225	56173	99447	56136222
Neutropenia	56.93	11.76	45	56353	158122	56077547
Drug abuse	55.42	11.76	3	56395	67607	56168062
Dizziness	55.41	11.76	598	55800	375542	55860127
Death	55.10	11.76	553	55845	340873	55894796
Pulmonary veno-occlusive disease	54.97	11.76	25	56373	1038	56234631
Cyanosis	54.41	11.76	73	56325	15737	56219932
Cor pulmonale	53.46	11.76	30	56368	1951	56233718
Unevaluable event	53.07	11.76	135	56263	47552	56188117
Pericardial effusion	52.24	11.76	96	56302	27079	56208590
Flushing	51.49	11.76	171	56227	69929	56165740
Catheter site pain	51.30	11.76	39	56359	4254	56231415
Malaise	47.91	11.76	571	55827	367289	55868380
Device related infection	46.82	11.76	81	56317	21799	56213870
Catheter site discharge	46.72	11.76	27	56371	1858	56233811
Therapeutic product effect incomplete	46.59	11.76	24	56374	106007	56129662
Pruritus	45.90	11.76	163	56235	316460	55919209
Blister	45.87	11.76	26	56372	108861	56126808
Psoriasis	45.38	11.76	18	56380	92674	56142995
Catheter site infection	45.30	11.76	37	56361	4477	56231192
Exercise tolerance decreased	45.13	11.76	39	56359	5099	56230570
Chest discomfort	44.74	11.76	207	56191	98650	56137019
Dyspnoea at rest	44.15	11.76	34	56364	3779	56231890
Impaired healing	43.96	11.76	16	56382	86825	56148844
Chronic respiratory failure	43.25	11.76	25	56373	1721	56233948
Injection site erythema	43.23	11.76	12	56386	77436	56158233
Intentional overdose	43.13	11.76	8	56390	68109	56167560
Orthopnoea	42.89	11.76	40	56358	5776	56229893
Transplant evaluation	42.37	11.76	21	56377	1059	56234610
Respiratory distress	42.05	11.76	96	56302	31571	56204098
Bronchitis	41.48	11.76	222	56176	112089	56123580
Irritable bowel syndrome	41.34	11.76	9	56389	68449	56167220
Injection site pain	41.28	11.76	34	56364	117084	56118585
Suicide attempt	40.72	11.76	5	56393	57831	56177838
Left ventricular failure	40.04	11.76	36	56362	4960	56230709
Catheter site rash	39.63	11.76	18	56380	745	56234924
Exposure during pregnancy	39.53	11.76	47	56351	136295	56099374
Hospitalisation	39.21	11.76	164	56234	74836	56160833
Infusion site pain	39.13	11.76	58	56340	13704	56221965
Blood cholesterol increased	39.13	11.76	12	56386	72567	56163102
Lung disorder	38.35	11.76	128	56270	52469	56183200
Pulmonary arterial pressure abnormal	37.39	11.76	15	56383	455	56235214
Pulmonary hypertensive crisis	36.35	11.76	12	56386	205	56235464
Nasal dryness	35.70	11.76	30	56368	3776	56231893
Abdominal distension	35.45	11.76	163	56235	77463	56158206
Presyncope	34.46	11.76	78	56320	25504	56210165
Overdose	33.41	11.76	34	56364	105796	56129873
Urticaria	32.98	11.76	59	56339	144617	56091052
Aspiration pleural cavity	32.97	11.76	16	56382	770	56234899
Atrial flutter	32.57	11.76	43	56355	9126	56226543
Pulmonary congestion	32.33	11.76	58	56340	16057	56219612
Injection site reaction	32.15	11.76	7	56391	53240	56182429
Oxygen saturation abnormal	31.76	11.76	25	56373	2869	56232800
Bladder agenesis	31.74	11.76	10	56388	146	56235523
Ascites	31.59	11.76	96	56302	37448	56198221
Interstitial lung disease	31.58	11.76	127	56271	56936	56178733
Catheter placement	31.48	11.76	22	56376	2106	56233563
Air embolism	31.34	11.76	11	56387	228	56235441
Oxygen consumption	31.32	11.76	9	56389	94	56235575
Cloacal exstrophy	31.31	11.76	10	56388	153	56235516
Genitalia external ambiguous	31.31	11.76	10	56388	153	56235516
Emphysema	31.22	11.76	44	56354	9932	56225737
Cardiac disorder	31.11	11.76	109	56289	45778	56189891
Respiratory tract infection	31.07	11.76	93	56305	35978	56199691
Febrile neutropenia	31.00	11.76	36	56362	105509	56130160
Congenital ectopic bladder	30.98	11.76	9	56389	98	56235571
Cardiac arrest	30.77	11.76	169	56229	86145	56149524
Mobility decreased	29.90	11.76	33	56365	98958	56136711
Thermal burn	29.88	11.76	32	56366	5453	56230216
Cardiac pacemaker insertion	29.77	11.76	27	56371	3763	56231906
Condition aggravated	29.76	11.76	498	55900	344400	55891269
Meconium stain	29.40	11.76	10	56388	188	56235481
Subcutaneous emphysema	29.34	11.76	15	56383	808	56234861
Cardiac failure acute	29.06	11.76	40	56358	8833	56226836
Gastrointestinal disorder congenital	28.59	11.76	9	56389	131	56235538
Rales	28.43	11.76	44	56354	10796	56224873
Device occlusion	28.42	11.76	34	56364	6535	56229134
Anaemia	28.34	11.76	400	55998	267111	55968558
Central venous catheterisation	28.26	11.76	22	56376	2485	56233184
Swelling	28.10	11.76	134	56264	239637	55996032
Ill-defined disorder	27.96	11.76	17	56381	68526	56167143
Congenital genital malformation	27.92	11.76	9	56389	142	56235527
Tethered cord syndrome	27.73	11.76	10	56388	225	56235444
Gamma-glutamyltransferase increased	27.72	11.76	81	56317	30924	56204745
Device leakage	27.59	11.76	33	56365	6342	56229327
Paracentesis	27.57	11.76	15	56383	918	56234751
Lipodystrophy acquired	27.31	11.76	17	56381	1340	56234329
Cardiac ablation	27.19	11.76	17	56381	1350	56234319
Caudal regression syndrome	26.67	11.76	9	56389	165	56235504
Knee arthroplasty	26.35	11.76	6	56392	44253	56191416
Atrial fibrillation	26.25	11.76	193	56205	108704	56126965
Gastrointestinal malformation	26.13	11.76	9	56389	176	56235493
Leukopenia	25.74	11.76	20	56378	70920	56164749
Anaesthetic complication	25.66	11.76	18	56380	1734	56233935
Suicidal ideation	25.46	11.76	13	56385	57729	56177940
Abdominal discomfort	25.41	11.76	168	56230	277106	55958563
Intentional product use issue	25.22	11.76	38	56360	99695	56135974
Pulmonary function test decreased	25.15	11.76	24	56374	3567	56232102
Lower respiratory tract infection	25.11	11.76	48	56350	114746	56120923
Catheter site scab	25.02	11.76	9	56389	201	56235468
N-terminal prohormone brain natriuretic peptide increased	24.85	11.76	18	56380	1824	56233845
Blood iron decreased	24.76	11.76	45	56353	12582	56223087
Heart rate increased	24.49	11.76	155	56243	83118	56152551
Haemoglobin decreased	24.39	11.76	223	56175	133914	56101755
Liver injury	24.27	11.76	6	56392	41842	56193827
Product use in unapproved indication	23.50	11.76	68	56330	140754	56094915
Cognitive disorder	23.30	11.76	10	56388	49123	56186546
Anal atresia	22.79	11.76	10	56388	381	56235288
Depression	22.69	11.76	98	56300	180019	56055650
Rhinorrhoea	22.60	11.76	115	56283	56922	56178747
Anencephaly	22.56	11.76	9	56389	269	56235400
Walking distance test abnormal	22.48	11.76	11	56387	539	56235130
Injection site pruritus	22.48	11.76	7	56391	41924	56193745
Disease progression	22.35	11.76	181	56217	104992	56130677
Catheter site swelling	22.12	11.76	15	56383	1368	56234301
Haematocrit decreased	22.02	11.76	84	56314	36745	56198924
Sputum discoloured	22.01	11.76	46	56352	14246	56221423
Neuromuscular blockade	21.87	11.76	9	56389	292	56235377
Device connection issue	21.77	11.76	11	56387	578	56235091
Red blood cell sedimentation rate increased	21.74	11.76	5	56393	36618	56199051
Neural tube defect	21.70	11.76	8	56390	192	56235477
Congestive hepatopathy	21.51	11.76	19	56379	2557	56233112
Aspartate aminotransferase increased	21.41	11.76	149	56249	82453	56153216
Iron deficiency anaemia	21.27	11.76	52	56346	17867	56217802
Osteoarthritis	20.88	11.76	30	56368	80266	56155403
Concomitant disease progression	20.75	11.76	17	56381	2065	56233604
Nocturnal dyspnoea	20.72	11.76	13	56385	1039	56234630
Adverse drug reaction	20.46	11.76	21	56377	65111	56170558
Upper respiratory tract inflammation	20.15	11.76	18	56380	2459	56233210
Stent placement	19.84	11.76	21	56377	3530	56232139
Infusion site erythema	19.82	11.76	35	56363	9571	56226098
Cardiomegaly	19.77	11.76	48	56350	16419	56219250
Pneumothorax	19.66	11.76	45	56353	14822	56220847
Right ventricular dysfunction	19.58	11.76	15	56383	1654	56234015
Confusional state	19.12	11.76	126	56272	208029	56027640
Gastrointestinal disorder	19.11	11.76	54	56344	112648	56123021
Injection site swelling	18.93	11.76	10	56388	43568	56192101
Pulmonary artery banding	18.63	11.76	4	56394	10	56235659
Localised oedema	18.58	11.76	24	56374	4985	56230684
Multiple sclerosis relapse	18.50	11.76	11	56387	44892	56190777
Meningomyelocele	18.49	11.76	10	56388	605	56235064
Umbilical cord abnormality	18.47	11.76	10	56388	606	56235063
Sepsis neonatal	18.42	11.76	9	56389	440	56235229
Pulmonary alveolar haemorrhage	18.33	11.76	22	56376	4242	56231427
Uterine hypotonus	18.04	11.76	6	56392	105	56235564
C-reactive protein increased	18.00	11.76	32	56366	78652	56157017
Hyperandrogenism	17.94	11.76	6	56392	107	56235562
Malignant neoplasm progression	17.69	11.76	29	56369	73558	56162111
Hepatic function abnormal	17.61	11.76	75	56323	34483	56201186
Infusion site infection	17.55	11.76	14	56384	1638	56234031
Tachypnoea	17.49	11.76	44	56354	15386	56220283
Product dose omission issue	17.38	11.76	295	56103	204458	56031211
Mediastinal effusion	17.33	11.76	5	56393	53	56235616
Supraventricular tachycardia	17.32	11.76	40	56358	13251	56222418
Gout	17.29	11.76	38	56360	12183	56223486
Sepsis	17.23	11.76	215	56183	139625	56096044
Cardioversion	17.17	11.76	12	56386	1149	56234520
Osteonecrosis of jaw	17.12	11.76	6	56392	33352	56202317
Bronchospasm	17.05	11.76	44	56354	15625	56220044
Paraesthesia	17.05	11.76	70	56328	130444	56105225
Right ventricular systolic pressure increased	17.04	11.76	9	56389	519	56235150
Upper respiratory tract infection	16.98	11.76	126	56272	71162	56164507
Injury	16.94	11.76	21	56377	59830	56175839
Oxygen consumption decreased	16.92	11.76	7	56391	230	56235439
Coma	16.82	11.76	21	56377	59634	56176035
Exomphalos	16.64	11.76	9	56389	544	56235125
Ventilation perfusion mismatch	16.56	11.76	7	56391	243	56235426
Abdominal cavity drainage	16.47	11.76	8	56390	386	56235283
Argon plasma coagulation	16.32	11.76	4	56394	21	56235648
Feeling abnormal	16.28	11.76	205	56193	133397	56102272
Terminal state	16.25	11.76	15	56383	2138	56233531
Platelet transfusion	16.23	11.76	10	56388	774	56234895
Oedematous kidney	16.20	11.76	5	56393	68	56235601
Hospice care	16.09	11.76	25	56373	6155	56229514
Enlarged clitoris	16.04	11.76	6	56392	150	56235519
Pulmonary pain	16.04	11.76	17	56381	2863	56232806
Pulmonary artery dilatation	15.92	11.76	7	56391	268	56235401
Wheezing	15.87	11.76	129	56269	74897	56160772
Fibromyalgia	15.76	11.76	22	56376	59581	56176088
Pulmonary haemorrhage	15.69	11.76	26	56372	6757	56228912
Cold burn	15.64	11.76	3	56395	3	56235666
Acute postoperative sialadenitis	15.59	11.76	4	56394	26	56235643
Echocardiogram	15.46	11.76	4	56394	27	56235642
Accident	15.45	11.76	23	56375	5453	56230216
Jugular vein distension	15.25	11.76	10	56388	862	56234807
Tracheostomy	15.15	11.76	9	56389	652	56235017
Pulmonary capillary haemangiomatosis	15.10	11.76	4	56394	30	56235639
Rehabilitation therapy	15.09	11.76	12	56386	1398	56234271
Breath sounds abnormal	15.07	11.76	30	56368	8977	56226692
PO2 decreased	15.06	11.76	12	56386	1401	56234268
Lung assist device therapy	15.01	11.76	5	56393	88	56235581
Pneumonia bacterial	14.97	11.76	28	56370	8000	56227669
Procedural hypotension	14.94	11.76	11	56387	1143	56234526
Neuropathy peripheral	14.85	11.76	53	56345	102840	56132829
Rhonchi	14.85	11.76	15	56383	2389	56233280
Blood urea increased	14.78	11.76	56	56342	24417	56211252
Idiopathic pulmonary fibrosis	14.68	11.76	12	56386	1454	56234215
Bone marrow failure	14.67	11.76	5	56393	28281	56207388
Red blood cell count decreased	14.62	11.76	74	56324	36543	56199126
Systemic scleroderma	14.53	11.76	10	56388	934	56234735
Paradoxical embolism	14.45	11.76	4	56394	36	56235633
Tachycardia	14.45	11.76	166	56232	105710	56129959
Neoplasm progression	14.43	11.76	7	56391	32009	56203660
Carbon dioxide increased	14.42	11.76	11	56387	1206	56234463
Hypoglycaemia	14.36	11.76	21	56377	55794	56179875
Decreased appetite	14.19	11.76	303	56095	218928	56016741
Bursitis	14.09	11.76	5	56393	27577	56208092
Secretion discharge	14.03	11.76	32	56366	10514	56225155
Catheter site warmth	14.02	11.76	6	56392	215	56235454
COVID-19 pneumonia	14.02	11.76	33	56365	11069	56224600
Therapy change	14.01	11.76	22	56376	5466	56230203
Catheter site inflammation	13.98	11.76	9	56389	752	56234917
Catheter site hypersensitivity	13.88	11.76	5	56393	112	56235557
Hip arthroplasty	13.87	11.76	11	56387	38612	56197057
Middle ear effusion	13.87	11.76	14	56384	2228	56233441
Weight decreased	13.79	11.76	327	56071	240387	55995282
Injection site bruising	13.79	11.76	11	56387	38510	56197159
Blood pressure increased	13.77	11.76	87	56311	145089	56090580
Pregnancy	13.74	11.76	8	56390	33025	56202644
Type 2 diabetes mellitus	13.74	11.76	16	56382	46846	56188823
Dizziness exertional	13.73	11.76	7	56391	375	56235294
Increased bronchial secretion	13.72	11.76	12	56386	1595	56234074
Catheter site haemorrhage	13.68	11.76	16	56382	3002	56232667
Gastrointestinal arteriovenous malformation	13.68	11.76	8	56390	563	56235106
Biopsy liver	13.52	11.76	7	56391	387	56235282
Pneumomediastinum	13.52	11.76	11	56387	1324	56234345
Spina bifida	13.49	11.76	9	56389	799	56234870
Angioedema	13.44	11.76	13	56385	41440	56194229
Therapeutic response decreased	13.43	11.76	20	56378	52738	56182931
Mucosal inflammation	13.22	11.76	14	56384	42796	56192873
Colitis ulcerative	13.20	11.76	4	56394	24387	56211282
Apnoea	13.19	11.76	25	56373	7217	56228452
Rhabdomyolysis	12.89	11.76	13	56385	40645	56195024
Right ventricular dilatation	12.87	11.76	10	56388	1126	56234543
Urinary retention	12.86	11.76	6	56392	28068	56207601
Hepatitis	12.84	11.76	10	56388	35431	56200238
Hypertension	12.84	11.76	170	56228	244108	55991561
Choking	12.75	11.76	28	56370	8969	56226700
Therapy non-responder	12.71	11.76	105	56293	61250	56174419
Administration site pruritus	12.62	11.76	6	56392	276	56235393
Nasal discomfort	12.60	11.76	18	56380	4114	56231555
Neutrophil count decreased	12.57	11.76	19	56379	49803	56185866
Right ventricular hypertrophy	12.56	11.76	8	56390	656	56235013
Inflammation	12.53	11.76	32	56366	69039	56166630
Hypozincaemia	12.53	11.76	3	56395	14	56235655
Choking sensation	12.49	11.76	16	56382	3295	56232374
Vascular cauterisation	12.48	11.76	4	56394	62	56235607
Emergency care	12.47	11.76	9	56389	907	56234762
Polypectomy	12.45	11.76	8	56390	666	56235003
Dialysis	12.42	11.76	29	56369	9673	56225996
Cardiac failure high output	12.40	11.76	6	56392	287	56235382
Menstrual discomfort	12.36	11.76	3	56395	15	56235654
Lung squamous cell carcinoma stage I	12.36	11.76	3	56395	15	56235654
Decreased activity	12.34	11.76	21	56377	5575	56230094
Catheter site erosion	12.30	11.76	4	56394	65	56235604
Glossoptosis	12.25	11.76	4	56394	66	56235603
Acute right ventricular failure	12.18	11.76	5	56393	161	56235508
Oesophageal dilation procedure	12.08	11.76	4	56394	69	56235600
Brain hypoxia	12.07	11.76	7	56391	485	56235184
Rash maculo-papular	12.03	11.76	7	56391	28900	56206769
Chills	11.89	11.76	156	56242	102448	56133221
Abdominal pain	11.89	11.76	185	56213	258620	55977049
Stress cardiomyopathy	11.88	11.76	26	56372	8310	56227359

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	383.33	12.70	890	26836	342589	31327029
Oxygen saturation decreased	331.12	12.70	302	27424	48813	31620805
Pulmonary arterial hypertension	273.71	12.70	145	27581	9676	31659942
Hypoxia	225.56	12.70	248	27478	50065	31619553
Right ventricular failure	204.88	12.70	113	27613	8169	31661449
Chronic obstructive pulmonary disease	187.61	12.70	214	27512	44952	31624666
Oxygen consumption increased	171.16	12.70	58	27668	1244	31668374
Pulmonary hypertension	170.77	12.70	141	27585	19900	31649718
Respiratory failure	138.15	12.70	286	27440	101163	31568455
Fluid retention	117.55	12.70	126	27600	24676	31644942
Concomitant disease aggravated	114.87	12.70	66	27660	5158	31664460
Pneumonia	106.83	12.70	575	27151	334737	31334881
Acute respiratory failure	99.98	12.70	123	27603	27932	31641686
Dyspnoea exertional	82.67	12.70	133	27593	38704	31630914
Oxygen therapy	68.08	12.70	26	27700	794	31668824
Transfusion	65.55	12.70	54	27672	7586	31662032
Toxicity to various agents	63.87	12.70	40	27686	181447	31488171
Pain in jaw	62.92	12.70	65	27661	12190	31657428
Thermal burn	61.52	12.70	34	27692	2464	31667154
Hypervolaemia	60.19	12.70	77	27649	18174	31651444
Nasal congestion	56.50	12.70	79	27647	20302	31649316
Completed suicide	56.09	12.70	7	27719	91507	31578111
Respiratory distress	53.26	12.70	101	27625	33452	31636166
Cerebral artery thrombosis	52.10	12.70	21	27705	742	31668876
Drug abuse	50.76	12.70	8	27718	87750	31581868
Brain scan abnormal	49.72	12.70	21	27705	837	31668781
Pulmonary oedema	48.61	12.70	115	27611	44387	31625231
Idiopathic pulmonary fibrosis	48.11	12.70	35	27691	4095	31665523
Cough	48.03	12.70	239	27487	134575	31535043
Pulmonary arterial pressure increased	45.61	12.70	22	27704	1200	31668418
Brain natriuretic peptide increased	38.80	12.70	33	27693	4843	31664775
Hypercapnia	38.17	12.70	30	27696	3941	31665677
Condition aggravated	35.36	12.70	255	27471	163754	31505864
Oedema	35.12	12.70	99	27627	42462	31627156
Neutropenia	34.78	12.70	43	27683	140321	31529297
Pneumothorax	34.72	12.70	57	27669	16853	31652765
Lung transplant	34.24	12.70	21	27705	1849	31667769
Blood pressure decreased	34.11	12.70	106	27620	47985	31621633
Haemoptysis	33.86	12.70	82	27644	32107	31637511
Catheter site erythema	33.49	12.70	18	27708	1234	31668384
Areflexia	33.11	12.70	24	27702	2792	31666826
Catheter management	30.47	12.70	15	27711	856	31668762
Cor pulmonale	30.18	12.70	14	27712	699	31668919
Drug ineffective	29.99	12.70	213	27513	395360	31274258
Cardiac arrest	28.96	12.70	154	27572	88908	31580710
Rheumatoid arthritis	28.46	12.70	4	27722	47805	31621813
Emphysema	28.41	12.70	37	27689	8881	31660737
Cardiac failure	28.20	12.70	149	27577	85804	31583814
Oedema peripheral	27.34	12.70	177	27549	109662	31559956
Chronic respiratory failure	27.22	12.70	16	27710	1304	31668314
Lung disorder	26.50	12.70	75	27651	32237	31637381
Pulmonary function test abnormal	26.28	12.70	19	27707	2202	31667416
Neuromuscular block prolonged	25.73	12.70	11	27715	452	31669166
Cyanosis	24.69	12.70	40	27686	11695	31657923
Mechanical ventilation	24.37	12.70	17	27709	1862	31667756
Catheter removal	23.08	12.70	8	27718	184	31669434
Catheterisation cardiac	22.94	12.70	18	27708	2358	31667260
Catheter site haemorrhage	22.78	12.70	17	27709	2067	31667551
Accident	22.37	12.70	22	27704	3889	31665729
Pulmonary veno-occlusive disease	22.23	12.70	10	27716	465	31669153
Transplant evaluation	21.77	12.70	10	27716	488	31669130
Air embolism	21.40	12.70	7	27719	134	31669484
Intentional overdose	21.32	12.70	5	27721	41384	31628234
Catheter placement	21.27	12.70	11	27715	697	31668921
Subacute combined cord degeneration	20.97	12.70	7	27719	143	31669475
Rotavirus infection	20.60	12.70	9	27717	390	31669228
Hypotension	20.56	12.70	271	27455	204347	31465271
Catheter site pain	20.48	12.70	13	27713	1216	31668402
Pulmonary function test decreased	20.27	12.70	22	27704	4363	31665255
Carbon dioxide increased	20.09	12.70	12	27714	1007	31668611
Headache	20.04	12.70	247	27479	183405	31486213
Catheter site discharge	19.95	12.70	10	27716	593	31669025
Anaesthetic complication	19.93	12.70	12	27714	1022	31668596
Catheter site granuloma	19.72	12.70	5	27721	36	31669582
Pulmonary fibrosis	19.21	12.70	44	27682	16616	31653002
Interstitial lung disease	19.15	12.70	105	27621	61298	31608320
Hyperthermia malignant	19.09	12.70	15	27711	1969	31667649
Catheter site pruritus	19.06	12.70	8	27718	314	31669304
Bradycardia	18.65	12.70	114	27612	69213	31600405
Burns third degree	18.57	12.70	7	27719	206	31669412
Productive cough	18.53	12.70	68	27658	33472	31636146
Aggression	18.26	12.70	5	27721	37286	31632332
Suicide attempt	18.22	12.70	5	27721	37243	31632375
Burns second degree	18.11	12.70	8	27718	356	31669262
Catheter site warmth	18.00	12.70	5	27721	53	31669565
Hyponatraemia	17.85	12.70	23	27703	73776	31595842
Respiratory acidosis	17.50	12.70	21	27705	4641	31664977
Treatment failure	17.30	12.70	7	27719	40785	31628833
Cardiac failure congestive	16.81	12.70	123	27603	79264	31590354
Ventricular tachycardia	16.57	12.70	52	27674	23649	31645969
Hypocapnia	16.37	12.70	6	27720	163	31669455
Ventilation perfusion mismatch	16.23	12.70	5	27721	78	31669540
Pulmonary hypertensive crisis	16.23	12.70	6	27720	167	31669451
Therapeutic product effect incomplete	16.22	12.70	9	27717	43687	31625931
Epistaxis	16.18	12.70	91	27635	53616	31616002
Walking distance test abnormal	16.17	12.70	6	27720	169	31669449
Infusion site vesicles	16.13	12.70	6	27720	170	31669448
Accidental underdose	16.06	12.70	8	27718	468	31669150
Pulse pressure decreased	15.84	12.70	6	27720	179	31669439
Anaesthetic complication cardiac	15.76	12.70	4	27722	29	31669589
Thoracic cavity drainage	15.69	12.70	6	27720	184	31669434
Respiratory tract infection	15.62	12.70	42	27684	17519	31652099
Confusional state	15.51	12.70	62	27664	133272	31536346
Psoriasis	15.45	12.70	11	27715	46708	31622910
PaO2/FiO2 ratio decreased	15.30	12.70	4	27722	33	31669585
Tachypnoea	15.25	12.70	40	27686	16443	31653175
Acute kidney injury	15.18	12.70	164	27562	279550	31390068
Barotrauma	15.09	12.70	4	27722	35	31669583
Pulmonary capillary haemangiomatosis	15.09	12.70	4	27722	35	31669583
Dependence on oxygen therapy	15.05	12.70	6	27720	206	31669412
Catheter site inflammation	14.99	12.70	6	27720	208	31669410
Complication associated with device	14.97	12.70	21	27705	5408	31664210
White blood cell count decreased	14.93	12.70	34	27692	87364	31582254
Pulmonary congestion	14.65	12.70	34	27692	12949	31656669
Abdominal pain	14.48	12.70	72	27654	145880	31523738
Drug interaction	14.44	12.70	115	27611	208428	31461190
Acute right ventricular failure	14.26	12.70	5	27721	119	31669499
Hemiplegia	14.26	12.70	23	27703	6699	31662919
Pulseless electrical activity	14.24	12.70	23	27703	6704	31662914
Pulmonary alveolar haemorrhage	14.15	12.70	23	27703	6743	31662875
Apnoea	14.02	12.70	22	27704	6260	31663358
Pneumomediastinum	13.98	12.70	13	27713	2144	31667474
Thrombocytopenia	13.83	12.70	71	27655	142676	31526942
Syncope	13.71	12.70	124	27602	85058	31584560
Dyspnoea at rest	13.41	12.70	16	27710	3515	31666103
Aspartate aminotransferase increased	13.17	12.70	97	27629	62622	31606996
Leukopenia	13.00	12.70	19	27707	57809	31611809
Procedural complication	12.95	12.70	17	27709	4112	31665506
Rectal haemorrhage	12.74	12.70	8	27718	36296	31633322

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	1064.81	11.38	2398	70719	767662	70087665
Pulmonary arterial hypertension	870.64	11.38	496	72621	32359	70822968
Oxygen saturation decreased	784.14	11.38	770	72347	115659	70739668
Pulmonary hypertension	599.74	11.38	447	72670	46089	70809238
Oxygen consumption increased	572.46	11.38	206	72911	4474	70850853
Right ventricular failure	554.54	11.38	323	72794	21951	70833376
Fluid retention	480.82	11.38	448	72669	62937	70792390
Hypoxia	456.47	11.38	521	72596	92823	70762504
Dyspnoea exertional	409.45	11.38	453	72664	77977	70777350
Chronic obstructive pulmonary disease	363.76	11.38	424	72693	77217	70778110
Respiratory failure	281.56	11.38	570	72547	168165	70687162
Hypervolaemia	256.41	11.38	257	72860	39449	70815878
Transfusion	249.38	11.38	184	72933	18652	70836675
Pain in jaw	239.19	11.38	256	72861	42413	70812914
Drug ineffective	236.47	11.38	379	72738	939373	69915954
Oxygen therapy	219.56	11.38	86	73031	2376	70852951
Pneumonia	214.48	11.38	1192	71925	595040	70260287
Acute respiratory failure	207.34	11.38	266	72851	53399	70801928
Rheumatoid arthritis	204.48	11.38	29	73088	291776	70563551
Completed suicide	202.93	11.38	7	73110	227128	70628199
Toxicity to various agents	198.61	11.38	73	73044	382099	70473228
Nasal congestion	195.58	11.38	287	72830	65385	70789942
Concomitant disease aggravated	189.49	11.38	131	72986	11983	70843344
Oedema peripheral	164.45	11.38	563	72554	227528	70627799
Pulmonary oedema	141.88	11.38	282	72835	81996	70773331
Cough	138.23	11.38	682	72435	324695	70530632
Oedema	135.03	11.38	317	72800	103264	70752063
Pulmonary arterial pressure increased	130.26	11.38	71	73046	4238	70851089
Catheter site erythema	123.74	11.38	72	73045	4876	70850451
Drug abuse	117.51	11.38	9	73108	147247	70708080
Cardiac failure	112.85	11.38	365	72752	143176	70712151
Contraindicated product administered	110.98	11.38	7	73110	134605	70720722
Brain natriuretic peptide increased	108.54	11.38	80	73037	8091	70847236
Therapeutic product effect decreased	108.01	11.38	11	73106	143007	70712320
Catheter site pruritus	107.58	11.38	50	73067	2121	70853206
Treatment failure	101.64	11.38	14	73103	144128	70711199
Lung transplant	100.90	11.38	60	73057	4230	70851097
Chest pain	99.80	11.38	517	72600	250743	70604584
Headache	98.44	11.38	971	72146	579434	70275893
Neutropenia	98.20	11.38	73	73044	257083	70598244
Productive cough	98.01	11.38	236	72881	78101	70777226
Blood pressure decreased	95.08	11.38	257	72860	91258	70764069
Haemoptysis	93.10	11.38	180	72937	51272	70804055
Arthropathy	91.88	11.38	21	73096	150036	70705291
Hypercapnia	91.86	11.38	73	73044	8256	70847071
Catheter management	88.26	11.38	51	73066	3408	70851919
Drug intolerance	86.24	11.38	64	73053	225623	70629704
Catheterisation cardiac	84.87	11.38	58	73059	5205	70850122
Alopecia	82.92	11.38	51	73066	198439	70656888
Drug hypersensitivity	81.72	11.38	90	73027	262369	70592958
Epistaxis	80.65	11.38	261	72856	102366	70752961
Respiratory distress	76.41	11.38	172	72945	54478	70800849
Syncope	75.00	11.38	354	72763	165355	70689972
Cyanosis	72.80	11.38	104	73013	23102	70832225
Rash	71.30	11.38	278	72839	510284	70345043
Scleroderma	71.05	11.38	51	73066	4950	70850377
Joint swelling	70.19	11.38	95	73022	253116	70602211
Hand deformity	69.80	11.38	5	73112	86477	70768850
Catheter site pain	69.07	11.38	50	73067	4918	70850409
Pulmonary veno-occlusive disease	68.81	11.38	33	73084	1503	70853824
Thermal burn	67.60	11.38	55	73062	6431	70848896
Dependence on oxygen therapy	67.05	11.38	23	73094	431	70854896
Intentional overdose	66.09	11.38	11	73106	98424	70756903
Glossodynia	64.39	11.38	7	73110	86480	70768847
Hypotension	62.39	11.38	664	72453	403717	70451610
Unevaluable event	62.07	11.38	154	72963	51909	70803418
Catheter site discharge	61.93	11.38	35	73082	2242	70853085
Device alarm issue	61.68	11.38	33	73084	1897	70853430
Stomatitis	61.03	11.38	28	73089	128483	70726844
Condition aggravated	59.95	11.38	689	72428	426946	70428381
Pericarditis	57.91	11.38	9	73108	84696	70770631
Musculoskeletal stiffness	57.60	11.38	41	73076	147719	70707608
Chronic respiratory failure	56.02	11.38	35	73082	2697	70852630
Flushing	54.91	11.38	198	72919	81974	70773353
Pleural effusion	54.49	11.38	276	72841	132588	70722739
Catheter site infection	54.11	11.38	47	73070	6013	70849314
Cardiac failure congestive	53.89	11.38	279	72838	135178	70720149
Pericardial effusion	53.46	11.38	127	72990	41649	70813678
Palpitations	53.33	11.38	241	72876	110512	70744815
Pulmonary hypertensive crisis	52.74	11.38	18	73099	332	70854995
Device related infection	52.68	11.38	108	73009	32077	70823250
Overdose	51.93	11.38	59	73058	169686	70685641
Off label use	51.07	11.38	505	72612	742555	70112772
Suicide attempt	50.96	11.38	10	73107	79500	70775827
Hepatic enzyme increased	50.88	11.38	52	73065	156938	70698389
Dizziness	50.66	11.38	714	72403	463427	70391900
Arthralgia	50.56	11.38	308	72809	503082	70352245
Transplant evaluation	50.39	11.38	27	73090	1557	70853770
Therapeutic product effect incomplete	49.77	11.38	31	73086	119851	70735476
Air embolism	49.16	11.38	18	73099	411	70854916
Catheter placement	48.80	11.38	32	73085	2681	70852646
Systemic lupus erythematosus	48.70	11.38	22	73095	101880	70753447
Emphysema	47.99	11.38	68	73049	14992	70840335
Hypersensitivity	47.41	11.38	104	73013	229708	70625619
Infusion related reaction	47.15	11.38	82	73035	197452	70657875
Catheter site rash	46.56	11.38	22	73095	969	70854358
Psoriasis	45.88	11.38	22	73095	98411	70756916
Cor pulmonale	45.81	11.38	28	73089	2075	70853252
Injection site pain	42.81	11.38	35	73082	117584	70737743
Dyspnoea at rest	41.92	11.38	43	73074	6776	70848551
Lung disorder	41.08	11.38	161	72956	69323	70786004
Pulmonary function test decreased	40.21	11.38	42	73075	6759	70848568
Febrile neutropenia	40.08	11.38	95	73022	204223	70651104
Idiopathic pulmonary fibrosis	40.07	11.38	36	73081	4815	70850512
Anaesthetic complication	40.03	11.38	28	73089	2608	70852719
Brain scan abnormal	40.01	11.38	21	73096	1161	70854166
Infusion site pain	39.51	11.38	54	73063	11510	70843817
Nasal dryness	39.26	11.38	32	73085	3751	70851576
Confusional state	38.88	11.38	156	72961	284242	70571085
Cerebral artery thrombosis	38.74	11.38	20	73097	1068	70854259
Orthopnoea	38.47	11.38	48	73069	9360	70845967
Pulmonary congestion	38.36	11.38	82	73035	25072	70830255
Cardiac arrest	38.26	11.38	289	72828	159545	70695782
Pain	37.65	11.38	441	72676	628375	70226952
Walking distance test abnormal	36.78	11.38	17	73100	712	70854615
Hospitalisation	36.31	11.38	175	72942	82393	70772934
Malaise	35.83	11.38	636	72481	432296	70423031
Helicobacter infection	35.67	11.38	7	73110	55649	70799678
Intentional product use issue	35.41	11.38	43	73074	120099	70735228
Discomfort	35.22	11.38	34	73083	105402	70749925
Exercise tolerance decreased	35.21	11.38	43	73074	8205	70847122
Cardiac failure acute	35.13	11.38	64	73053	17423	70837904
Pneumothorax	34.62	11.38	80	73037	25766	70829561
Injection site erythema	34.44	11.38	16	73101	72908	70782419
Device occlusion	33.99	11.38	48	73069	10547	70844780
Coma	33.83	11.38	27	73090	91817	70763510
Mobility decreased	33.50	11.38	34	73083	102965	70752362
Urticaria	33.43	11.38	74	73043	162975	70692352
Suicidal ideation	33.29	11.38	15	73102	69581	70785746
Left ventricular failure	33.27	11.38	43	73074	8685	70846642
Hypoglycaemia	33.21	11.38	29	73088	94335	70760992
Pruritus	32.80	11.38	215	72902	345345	70509982
Oxygen saturation abnormal	32.62	11.38	29	73088	3825	70851502
Leukopenia	32.62	11.38	37	73080	106523	70748804
Injection site reaction	32.52	11.38	6	73111	49846	70805481
Catheter site haemorrhage	32.51	11.38	32	73085	4799	70850528
Blood cholesterol increased	32.38	11.38	13	73104	64591	70790736
Abdominal distension	32.00	11.38	201	72916	104468	70750859
Neuromuscular block prolonged	31.96	11.38	17	73100	966	70854361
Mucosal inflammation	31.87	11.38	15	73102	67835	70787492
Pulmonary arterial pressure abnormal	31.61	11.38	15	73102	667	70854660
Impaired healing	31.19	11.38	19	73098	74355	70780972
Hyponatraemia	30.94	11.38	75	73042	160012	70695315
Acute kidney injury	30.69	11.38	327	72790	474297	70381030
N-terminal prohormone brain natriuretic peptide increased	30.22	11.38	28	73089	3896	70851431
Central venous catheterisation	30.10	11.38	25	73092	3008	70852319
Death	29.89	11.38	712	72405	509349	70345978
Malignant neoplasm progression	29.52	11.38	50	73067	121689	70733638
Cardiac ablation	29.45	11.38	21	73096	2017	70853310
Irritable bowel syndrome	29.39	11.38	8	73109	50842	70804485
Aggression	29.20	11.38	7	73110	48439	70806888
Abdominal pain	28.98	11.38	220	72897	341907	70513420
Chest discomfort	28.70	11.38	223	72894	124158	70731169
Depression	28.55	11.38	107	73010	198867	70656460
Pulmonary capillary haemangiomatosis	28.39	11.38	8	73109	75	70855252
Subcutaneous emphysema	28.22	11.38	19	73098	1663	70853664
Concomitant disease progression	28.17	11.38	25	73092	3290	70852037
Cardiac pacemaker insertion	27.94	11.38	31	73086	5341	70849986
Cognitive disorder	27.83	11.38	14	73103	60942	70794385
Paracentesis	27.80	11.38	17	73100	1261	70854066
Aspiration pleural cavity	27.75	11.38	18	73099	1480	70853847
Catheter site scab	27.61	11.38	10	73107	221	70855106
Pulmonary alveolar haemorrhage	27.55	11.38	43	73074	10326	70845001
Device connection issue	27.50	11.38	15	73102	896	70854431
Drug interaction	27.47	11.38	256	72861	381185	70474142
Ventilation perfusion mismatch	27.23	11.38	11	73106	330	70854997
Carbon dioxide increased	27.11	11.38	20	73097	2025	70853302
Catheter removal	27.03	11.38	13	73104	596	70854731
Osteonecrosis of jaw	26.60	11.38	5	73112	40997	70814330
Interstitial lung disease	26.58	11.38	192	72925	104493	70750834
Stevens-Johnson syndrome	26.49	11.38	3	73114	35904	70819423
Nocturnal dyspnoea	26.47	11.38	17	73100	1374	70853953
Drug resistance	26.23	11.38	4	73113	38186	70817141
Catheter site warmth	26.13	11.38	10	73107	259	70855068
Respiratory tract infection	25.67	11.38	99	73018	42299	70813028
Presyncope	25.67	11.38	91	73026	37347	70817980
Rash maculo-papular	25.61	11.38	10	73107	50535	70804792
Tachypnoea	25.40	11.38	76	73041	28562	70826765
Peripheral swelling	25.36	11.38	363	72754	236200	70619127
Bronchitis	25.29	11.38	207	72910	117036	70738291
Atrial flutter	25.15	11.38	61	73056	20266	70835061
Injection site pruritus	24.98	11.38	5	73112	39205	70816122
Heart rate increased	24.87	11.38	191	72926	105957	70749370
Pulseless electrical activity	24.84	11.38	47	73070	13168	70842159
Neuromuscular blockade	24.79	11.38	12	73105	558	70854769
Acute right ventricular failure	24.72	11.38	10	73107	301	70855026
Blister	24.64	11.38	41	73076	100485	70754842
Thrombocytopenia	24.63	11.38	145	72972	238965	70616362
Cardiomegaly	24.54	11.38	68	73049	24477	70830850
Right ventricular dysfunction	24.54	11.38	20	73097	2344	70852983
Neoplasm progression	24.53	11.38	8	73109	45220	70810107
Hyperthermia malignant	24.49	11.38	21	73096	2640	70852687
Rhabdomyolysis	24.46	11.38	38	73079	95722	70759605
Product use in unapproved indication	24.02	11.38	121	72996	207357	70647970
Accidental underdose	23.98	11.38	13	73104	767	70854560
Congestive hepatopathy	23.80	11.38	25	73092	4049	70851278
Pulmonary function test abnormal	23.64	11.38	23	73094	3402	70851925
Tracheostomy	23.51	11.38	15	73102	1199	70854128
Catheter site inflammation	23.22	11.38	14	73103	1012	70854315
Rhinorrhoea	23.19	11.38	132	72985	66239	70789088
Oxygen consumption	22.98	11.38	7	73110	88	70855239
Bone marrow failure	22.76	11.38	11	73106	48999	70806328
Sputum discoloured	22.71	11.38	56	73061	18795	70836532
Multiple sclerosis relapse	22.65	11.38	8	73109	43009	70812318
Wound	22.63	11.38	42	73075	98690	70756637
Device leakage	22.54	11.38	37	73080	9271	70846056
Neutrophil count decreased	22.47	11.38	32	73085	83524	70771803
Colitis ulcerative	22.30	11.38	4	73113	33919	70821408
Apnoea	22.27	11.38	40	73077	10769	70844558
Hepatitis	22.05	11.38	12	73105	49968	70805359
Colitis	21.99	11.38	20	73097	63794	70791533
Cardiac disorder	21.98	11.38	120	72997	59295	70796032
Psychotic disorder	21.66	11.38	6	73111	37695	70817632
Seizure	21.63	11.38	102	73015	177860	70677467
Cytomegalovirus infection	21.62	11.38	7	73110	39751	70815576
Mediastinal effusion	21.51	11.38	6	73111	54	70855273
Catheter site swelling	21.43	11.38	16	73101	1650	70853677
Infusion site infection	21.28	11.38	16	73101	1667	70853660
Gamma-glutamyltransferase increased	21.26	11.38	106	73011	50579	70804748
Catheter site granuloma	21.22	11.38	6	73111	57	70855270
Procedural complication	21.14	11.38	32	73085	7482	70847845
Injection site swelling	21.12	11.38	9	73108	43148	70812179
Feeling abnormal	21.08	11.38	232	72885	142087	70713240
Hypertension	20.74	11.38	200	72917	295833	70559494
Secretion discharge	20.69	11.38	43	73074	12890	70842437
Red blood cell sedimentation rate increased	20.67	11.38	7	73110	38635	70816692
Mouth ulceration	20.63	11.38	5	73112	34344	70820983
Rhonchi	20.59	11.38	22	73095	3633	70851694
Myocardial infarction	20.49	11.38	99	73018	171546	70683781
Agranulocytosis	20.37	11.38	8	73109	40290	70815037
Angioplasty	20.33	11.38	16	73101	1784	70853543
Inappropriate schedule of product administration	20.29	11.38	51	73066	107504	70747823
Pneumomediastinum	20.26	11.38	21	73096	3349	70851978
Anaesthetic complication cardiac	20.19	11.38	6	73111	69	70855258
Diabetic ketoacidosis	20.11	11.38	4	73113	31508	70823819
Platelet transfusion	20.08	11.38	17	73100	2101	70853226
Maternal exposure during pregnancy	20.02	11.38	57	73060	115288	70740039
Infusion site erythema	19.68	11.38	31	73086	7504	70847823
Right-to-left cardiac shunt	19.65	11.38	8	73109	245	70855082
Tubulointerstitial nephritis	19.50	11.38	5	73112	33071	70822256
Therapy non-responder	19.48	11.38	141	72976	76774	70778553
Atrial fibrillation	19.40	11.38	282	72835	184066	70671261
Uterine hypotonus	19.31	11.38	6	73111	81	70855246
Decreased activity	19.25	11.38	31	73086	7643	70847684
White blood cell count decreased	19.25	11.38	100	73017	170041	70685286
Abdominal cavity drainage	19.16	11.38	11	73106	726	70854601
Supraventricular tachycardia	19.11	11.38	54	73063	19656	70835671
Blood pressure increased	19.04	11.38	115	73002	188402	70666925
Neuropathy peripheral	19.01	11.38	67	73050	126829	70728498
Ascites	18.98	11.38	127	72990	67420	70787907
Emergency care	18.96	11.38	12	73105	946	70854381
C-reactive protein increased	18.90	11.38	55	73062	110462	70744865
Bronchospasm	18.83	11.38	59	73058	22733	70832594
Hallucination	18.78	11.38	31	73086	76229	70779098
Knee arthroplasty	18.72	11.38	6	73111	34295	70821032
Product use issue	18.58	11.38	109	73008	179828	70675499
Pulmonary artery banding	18.51	11.38	4	73113	10	70855317
Iron deficiency anaemia	18.40	11.38	59	73058	23013	70832314
Pulmonary artery dilatation	18.34	11.38	9	73108	431	70854896
Glossoptosis	17.98	11.38	7	73110	190	70855137
Pancreatitis	17.86	11.38	23	73094	62645	70792682
Blood alkaline phosphatase increased	17.64	11.38	112	73005	58409	70796918
Areflexia	17.62	11.38	24	73093	5098	70850229
Upper respiratory tract inflammation	17.56	11.38	21	73096	3921	70851406
Aspartate aminotransferase increased	17.45	11.38	204	72913	126774	70728553
Rotavirus infection	17.45	11.38	10	73107	658	70854669
Jugular vein distension	17.44	11.38	13	73104	1337	70853990
Respiratory acidosis	17.42	11.38	35	73082	10246	70845081
Eosinophilia	17.32	11.38	10	73107	40309	70815018
Ventricular tachycardia	17.32	11.38	79	73038	36344	70818983
Acute postoperative sialadenitis	17.28	11.38	5	73112	52	70855275
Cerebral haemorrhage	17.26	11.38	18	73099	53846	70801481
Brain hypoxia	17.19	11.38	11	73106	884	70854443
Choking sensation	17.16	11.38	20	73097	3635	70851692
Right ventricular enlargement	16.72	11.38	9	73108	524	70854803
Cerebral infarction	16.66	11.38	12	73105	42997	70812330
Right ventricular systolic pressure increased	16.64	11.38	11	73106	934	70854393
Exposure during pregnancy	16.23	11.38	42	73075	87675	70767652
Complication associated with device	16.17	11.38	44	73073	15669	70839658
Burns second degree	16.11	11.38	11	73106	985	70854342
Catheter site irritation	16.03	11.38	9	73108	569	70854758
Urine output decreased	15.97	11.38	46	73071	16924	70838403
Weight increased	15.93	11.38	344	72773	241987	70613340
Argon plasma coagulation	15.90	11.38	4	73113	23	70855304
Burns third degree	15.88	11.38	8	73109	406	70854921
Exercise test abnormal	15.86	11.38	5	73112	71	70855256
Pulmonary haemorrhage	15.82	11.38	40	73077	13633	70841694
Jaundice	15.77	11.38	17	73100	50091	70805236
Rales	15.70	11.38	46	73071	17089	70838238
Sinus disorder	15.59	11.38	49	73068	18910	70836417
Oral herpes	15.58	11.38	3	73114	24183	70831144
Cold burn	15.56	11.38	3	73114	3	70855324
Middle ear effusion	15.56	11.38	15	73102	2194	70853133
Injection site bruising	15.55	11.38	10	73107	38022	70817305
Rehabilitation therapy	15.53	11.38	13	73104	1582	70853745
Lower respiratory tract infection	15.52	11.38	61	73056	111852	70743475
Mechanical ventilation	15.37	11.38	16	73101	2565	70852762
Respiratory syncytial virus infection	15.36	11.38	28	73089	7627	70847700
Fibromyalgia	15.34	11.38	16	73101	47858	70807469
Cholestasis	15.34	11.38	16	73101	47856	70807471
Hepatocellular injury	15.23	11.38	15	73102	46076	70809251
Hospice care	15.19	11.38	29	73088	8176	70847151
Liver injury	15.19	11.38	12	73105	41023	70814304
Cardioversion	15.16	11.38	14	73103	1940	70853387
Dizziness postural	15.11	11.38	33	73084	10235	70845092
Procedural hypotension	15.09	11.38	14	73103	1952	70853375
Right ventricular dilatation	15.04	11.38	13	73104	1652	70853675
Product dose omission issue	15.04	11.38	311	72806	217157	70638170
PaO2/FiO2 ratio decreased	14.98	11.38	4	73113	30	70855297
Emotional distress	14.90	11.38	10	73107	37178	70818149
Inappropriate antidiuretic hormone secretion	14.76	11.38	3	73114	23273	70832054
COVID-19 pneumonia	14.72	11.38	53	73064	21916	70833411
Localised oedema	14.70	11.38	27	73090	7394	70847933
Angioedema	14.68	11.38	29	73088	66581	70788746
Barotrauma	14.49	11.38	6	73111	192	70855135
Decreased appetite	14.47	11.38	414	72703	304366	70550961
Agonal respiration	14.35	11.38	3	73114	6	70855321
Airway burns	14.35	11.38	3	73114	6	70855321
Poisoning	14.17	11.38	3	73114	22619	70832708
Paradoxical embolism	14.15	11.38	4	73113	38	70855289
Osteoarthritis	14.11	11.38	35	73082	74112	70781215
Catheter site hypersensitivity	13.91	11.38	5	73112	108	70855219
Incorrect dose administered	13.90	11.38	30	73087	66689	70788638
Pulmonary fibrosis	13.85	11.38	71	73046	34239	70821088
Accident	13.79	11.38	26	73091	7265	70848062
Delayed recovery from anaesthesia	13.75	11.38	12	73105	1545	70853782
Palmar-plantar erythrodysaesthesia syndrome	13.73	11.38	7	73110	30240	70825087
Disease progression	13.57	11.38	232	72885	156440	70698887
Breath sounds abnormal	13.57	11.38	37	73080	13194	70842133
Paraesthesia	13.56	11.38	91	73026	145446	70709881
Lung assist device therapy	13.50	11.38	5	73112	118	70855209
Rash pruritic	13.39	11.38	28	73089	62963	70792364
Terminal state	13.36	11.38	20	73097	4632	70850695
Wheezing	13.25	11.38	152	72965	94018	70761309
Blood creatine phosphokinase increased	13.22	11.38	27	73090	61236	70794091
Chronic left ventricular failure	13.18	11.38	9	73108	806	70854521
Pulmonary pain	13.11	11.38	17	73100	3445	70851882
Drug level increased	13.08	11.38	11	73106	36458	70818869
Thoracic cavity drainage	13.05	11.38	6	73111	248	70855079
Ill-defined disorder	12.80	11.38	23	73094	54718	70800609
Herpes zoster	12.77	11.38	45	73072	85190	70770137
Large intestinal polypectomy	12.66	11.38	6	73111	266	70855061
Vena cava filter insertion	12.63	11.38	5	73112	142	70855185
Blood carbon monoxide increased	12.63	11.38	3	73114	13	70855314
Systemic scleroderma	12.55	11.38	10	73107	1135	70854192
Right ventricular hypertrophy	12.52	11.38	11	73106	1429	70853898
Bradycardia	12.46	11.38	189	72928	124426	70730901
Basal cell carcinoma	12.29	11.38	10	73107	33688	70821639
Menstrual discomfort	12.28	11.38	3	73114	15	70855312
Myelosuppression	12.22	11.38	8	73109	30137	70825190
Atrial tachycardia	12.15	11.38	17	73100	3703	70851624
Cardiorenal syndrome	12.10	11.38	11	73106	1493	70853834
Plasma cell myeloma	12.10	11.38	37	73080	73164	70782163
Catheter site erosion	12.08	11.38	4	73113	67	70855260
Pulmonary vein stenosis	12.08	11.38	5	73112	160	70855167
Oedematous kidney	12.08	11.38	5	73112	160	70855167
Gastrointestinal tube insertion	12.04	11.38	11	73106	1503	70853824
Gastrointestinal arteriovenous malformation	12.04	11.38	9	73108	930	70854397
Frostbite	11.99	11.38	5	73112	163	70855164
Head injury	11.99	11.38	68	73049	34073	70821254
Puncture site infection	11.97	11.38	4	73113	69	70855258
Retching	11.96	11.38	40	73077	15939	70839388
Disturbance in attention	11.96	11.38	16	73101	42878	70812449
Lung infiltration	11.89	11.38	49	73068	21575	70833752
Oesophageal dilation procedure	11.86	11.38	4	73113	71	70855256
Joint range of motion decreased	11.85	11.38	6	73111	26020	70829307
Sopor	11.75	11.38	9	73108	31258	70824069
Haematoma evacuation	11.74	11.38	6	73111	314	70855013
Sinus congestion	11.71	11.38	42	73075	17331	70837996
Proteinuria	11.64	11.38	8	73109	29366	70825961
Upper respiratory tract infection	11.63	11.38	129	72988	79145	70776182
Nasal operation	11.58	11.38	5	73112	178	70855149
Stress cardiomyopathy	11.57	11.38	29	73088	9833	70845494
Product supply issue	11.55	11.38	11	73106	1584	70853743
Right ventricular systolic pressure	11.55	11.38	3	73114	20	70855307
Lung squamous cell carcinoma stage I	11.55	11.38	3	73114	20	70855307
Blood triglycerides increased	11.54	11.38	3	73114	19661	70835666
Nasal discomfort	11.51	11.38	19	73098	4782	70850545
Catheter site vesicles	11.51	11.38	6	73111	327	70855000
Sedation	11.50	11.38	19	73098	46712	70808615
Rhinovirus infection	11.50	11.38	23	73094	6710	70848617
Multiple allergies	11.49	11.38	25	73092	7735	70847592
Cardiac septal defect repair	11.42	11.38	3	73114	21	70855306
Ventricular extrasystoles	11.40	11.38	43	73074	18183	70837144
Polypectomy	11.38	11.38	9	73108	1010	70854317

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AN04	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Medical gases
CHEBI has role	CHEBI:77974	food packaging gases
CHEBI has role	CHEBI:78017	food propellants
CHEBI has role	CHEBI:33937	macronutrients

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Persistent pulmonary hypertension of the newborn	indication	233815004	DOID:13042
Methemoglobinemia	contraindication	38959009	DOID:10783
Left heart failure	contraindication	85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
None (Med Gas)	Air Liquide Industrial U.S. L.P.	2
None (Med Gas)	Air Liquide Large Industries U.S. L.P.	2
None (Med Gas)	Messer LLC	2
None (Med Gas)	Norco Inc.	2
None (Med Gas)	Messer Gas Puerto Rico Inc.	2
None (Med Gas)	Air Liquide America L.P.	2
None (Med Gas)	Airgas Merchant Gases LLC	2
None (Med Gas)	Praxair Inc.	2
None (Med Gas)	Aspen Air, US Corp	2
None (Med Gas)	Air Products and Chemicals Inc.	2
None (Med Gas)	Matheson Tri-Gas Inc.	2
None (Med Gas)	Praxair Canada Inc.	2
None (Med Gas)	Airgas USA LLC	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019163	VUID
N0000147408	NUI
D00083	KEGG_DRUG
4019163	VANDF
C0028158	UMLSCUI
CHEBI:25555	CHEBI
NGN	PDB_CHEM_ID
CHEMBL142438	ChEMBL_ID
D009584	MESH_DESCRIPTOR_UI
DB09152	DRUGBANK_ID
N762921K75	UNII
947	PUBCHEM_CID
7456	RXNORM
002515	NDDF
36012007	SNOMEDCT_US
767123001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10006-005	GAS	99 L	RESPIRATORY (INHALATION)	unapproved medical gas	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10014-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10014-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10018-9502	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10167-400	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10167-400	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10218-102	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10218-102	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10221-002	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10221-002	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10252-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10252-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-200	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10297-200	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10304-601	GAS	999 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10304-601	GAS	999 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10412-0095	GAS	99.50 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10412-0095	GAS	99.50 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10451-003	GAS	992 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10451-003	GAS	992 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-003	LIQUID	990 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-006	LIQUID	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10526-006	LIQUID	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-020	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-021	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-022	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROGEN	HUMAN PRESCRIPTION DRUG LABEL	1	10671-023	LIQUID	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10678-002	GAS	992 mL	RESPIRATORY (INHALATION)	unapproved medical gas	1 sections
Nitrogen	HUMAN PRESCRIPTION DRUG LABEL	1	10690-002	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections