povidone-iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
radiopharmaceuticals, iodine-contained	4249	25655-41-8

Description:

Molecule	Description
Synonyms: povidone-iodine povidone iodine iodine-povidone complex iodovidone proviodine	An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes. Molecular weight: Formula: I2(C6H9NO)n CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

povidone-iodine
povidone iodine
iodine-povidone complex
iodovidone
proviodine

An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.

Molecular weight:
Formula: I2(C6H9NO)n
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	V

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 29, 1985	FDA	BECTON DICKINSON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	920.41	23.72	154	5081	1617	63482170
Endophthalmitis	780.32	23.72	149	5086	3443	63480344
Hypopyon	259.52	23.72	46	5189	686	63483101
Corneal oedema	203.25	23.72	42	5193	1451	63482336
Visual acuity reduced	188.51	23.72	70	5165	21756	63462031
Drug hypersensitivity	185.15	23.72	173	5062	310514	63173273
Eye pain	136.48	23.72	63	5172	33791	63449996
Vitritis	135.56	23.72	28	5207	964	63482823
Anterior chamber cell	126.88	23.72	24	5211	520	63483267
Aqueous fibrin	125.13	23.72	18	5217	59	63483728
Tonsillar ulcer	120.48	23.72	21	5214	282	63483505
Retinopathy of prematurity	116.93	23.72	21	5214	338	63483449
Eye inflammation	104.19	23.72	32	5203	5567	63478220
Lower respiratory tract infection viral	97.19	23.72	21	5214	900	63482887
Anterior chamber fibrin	89.82	23.72	13	5222	45	63483742
Intraocular pressure increased	81.21	23.72	27	5208	6051	63477736
Ocular hyperaemia	80.60	23.72	40	5195	25104	63458683
Lip ulceration	80.48	23.72	21	5214	2029	63481758
Conjunctival oedema	79.69	23.72	17	5218	685	63483102
Punctate keratitis	70.27	23.72	15	5220	606	63483181
Vitreous floaters	69.84	23.72	24	5211	5942	63477845
Macular oedema	67.25	23.72	21	5214	3856	63479931
Oliguria	66.99	23.72	26	5209	9075	63474712
Corneal epithelium defect	66.41	23.72	13	5222	339	63483448
Bacterial endophthalmitis	66.17	23.72	11	5224	109	63483678
Tonsillitis	63.00	23.72	22	5213	5713	63478074
Post procedural discomfort	61.55	23.72	15	5220	1099	63482688
Parophthalmia	61.37	23.72	12	5223	311	63483476
Vision blurred	57.85	23.72	53	5182	91871	63391916
Metamorphopsia	55.88	23.72	14	5221	1149	63482638
Cataract nuclear	53.89	23.72	13	5222	912	63482875
Procedural pain	53.80	23.72	29	5206	21540	63462247
Visual impairment	53.74	23.72	49	5186	84397	63399390
Retinal haemorrhage	46.77	23.72	17	5218	4952	63478835
Corneal abrasion	46.47	23.72	12	5223	1112	63482675
Product contamination microbial	40.77	23.72	8	5227	211	63483576
Eye irritation	39.87	23.72	24	5211	21947	63461840
Foetal non-stress test abnormal	39.04	23.72	6	5229	34	63483753
Cystoid macular oedema	37.97	23.72	11	5224	1564	63482223
Anaphylactic reaction	37.50	23.72	36	5199	66064	63417723
Ophthalmological examination abnormal	35.04	23.72	6	5229	72	63483715
Eye oedema	33.93	23.72	10	5225	1510	63482277
Conjunctivitis	33.36	23.72	21	5214	20775	63463012
Off label use	33.15	23.72	126	5109	674336	62809451
Retinal disorder	32.88	23.72	10	5225	1680	63482107
Suspected transmission of an infectious agent via product	32.50	23.72	7	5228	295	63483492
Anterior chamber disorder	32.03	23.72	6	5229	123	63483664
Cataract operation complication	31.54	23.72	6	5229	134	63483653
Streptococcal sepsis	31.49	23.72	10	5225	1936	63481851
Retinal scar	31.12	23.72	6	5229	144	63483643
Vitreous detachment	31.09	23.72	10	5225	2017	63481770
Vitreous haemorrhage	30.98	23.72	10	5225	2040	63481747
Genital haemorrhage	30.61	23.72	14	5221	7318	63476469
Multiple use of single-use product	29.76	23.72	9	5226	1483	63482304
Exophthalmos	29.62	23.72	9	5226	1507	63482280
Blindness unilateral	29.51	23.72	13	5222	6228	63477559
Pseudomonal sepsis	29.43	23.72	10	5225	2391	63481396
Post procedural complication	29.30	23.72	18	5217	17056	63466731
Haematuria	29.15	23.72	22	5213	29135	63454652
Iridocyclitis	28.95	23.72	10	5225	2512	63481275
Eyelid oedema	28.70	23.72	15	5220	10464	63473323
Lacrimation increased	28.58	23.72	19	5216	20612	63463175
Retinal pigment epithelial tear	27.85	23.72	6	5229	253	63483534
Swollen tongue	27.78	23.72	23	5212	34777	63449010
Photopsia	26.64	23.72	11	5224	4498	63479289
Retinal oedema	26.64	23.72	7	5228	694	63483093
Foreign body sensation in eyes	26.19	23.72	9	5226	2225	63481562
Enterocutaneous fistula	26.05	23.72	8	5227	1389	63482398
Lymphopenia	25.68	23.72	17	5218	18310	63465477
Conjunctival hyperaemia	25.64	23.72	9	5226	2370	63481417
Blindness	25.37	23.72	18	5217	21681	63462106
Corneal infiltrates	25.30	23.72	5	5230	137	63483650
Transmission of an infectious agent via product	24.99	23.72	5	5230	146	63483641
Procedural haemorrhage	24.56	23.72	9	5226	2679	63481108
Vascular device infection	24.51	23.72	12	5223	7300	63476487
Delayed delivery	24.31	23.72	4	5231	37	63483750

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Endophthalmitis	542.59	26.36	112	3185	3396	34950238
Toxic anterior segment syndrome	467.94	26.36	83	3214	1086	34952548
Hypopyon	157.51	26.36	28	3269	368	34953266
Visual acuity reduced	147.83	26.36	56	3241	16093	34937541
Corneal oedema	139.59	26.36	31	3266	1320	34952314
Retinopathy of prematurity	130.82	26.36	21	3276	141	34953493
Eye pain	106.48	26.36	42	3255	13420	34940214
Vitritis	106.24	26.36	23	3274	868	34952766
Vision blurred	97.21	26.36	58	3239	45905	34907729
Vitreous floaters	96.12	26.36	28	3269	3557	34950077
Anterior chamber cell	94.27	26.36	18	3279	357	34953277
Eye inflammation	85.39	26.36	23	3274	2195	34951439
Aqueous fibrin	66.61	26.36	10	3287	40	34953594
Anterior chamber fibrin	65.85	26.36	10	3287	44	34953590
Ocular hyperaemia	61.09	26.36	27	3270	11425	34942209
Blindness	54.16	26.36	27	3270	14959	34938675
Visual impairment	48.04	26.36	34	3263	35768	34917866
Anaphylactic reaction	46.43	26.36	32	3265	32269	34921365
Vitreous disorder	39.21	26.36	7	3290	94	34953540
Anaphylactic shock	38.60	26.36	22	3275	15919	34937715
Macular oedema	37.43	26.36	13	3284	2901	34950733
Non-infectious endophthalmitis	36	26.36	7	3290	153	34953481
Eye irritation	34.52	26.36	16	3281	7545	34946089
Anterior chamber flare	34.01	26.36	6	3291	75	34953559
Eye oedema	33.77	26.36	9	3288	823	34952811
Vitreous detachment	33.19	26.36	9	3288	879	34952755
Metamorphopsia	32.68	26.36	8	3289	521	34953113
Retinal pigment epithelial tear	32.02	26.36	7	3290	276	34953358
Urine iodine increased	29.84	26.36	4	3293	5	34953629
Off label use	29.15	26.36	96	3201	419428	34534206
Diabetic retinal oedema	28.75	26.36	6	3291	189	34953445
Haemorrhoids thrombosed	28.42	26.36	6	3291	200	34953434
Toxic skin eruption	28.33	26.36	16	3281	11369	34942265
Retinal haemorrhage	27.13	26.36	12	3285	5077	34948557

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	1310.69	20.93	226	7161	2538	79734463
Endophthalmitis	1168.18	20.93	234	7153	6194	79730807
Hypopyon	365.63	20.93	67	7320	1075	79735926
Corneal oedema	321.42	20.93	69	7318	2551	79734450
Visual acuity reduced	270.72	20.93	102	7285	29367	79707634
Vitritis	229.97	20.93	49	7338	1745	79735256
Anterior chamber cell	217.31	20.93	42	7345	907	79736094
Aqueous fibrin	172.12	20.93	26	7361	112	79736889
Eye pain	149.91	20.93	72	7315	37506	79699495
Anterior chamber fibrin	143.85	20.93	23	7364	153	79736848
Eye inflammation	133.31	20.93	41	7346	6372	79730629
Ocular hyperaemia	112.33	20.93	54	7333	28152	79708849
Tonsillar ulcer	110.64	20.93	21	7366	410	79736591
Drug hypersensitivity	99.45	20.93	130	7257	298786	79438215
Vitreous floaters	92.36	20.93	32	7355	7224	79729777
Lower respiratory tract infection viral	88.86	20.93	21	7366	1199	79735802
Punctate keratitis	87.90	20.93	20	7367	966	79736035
Vision blurred	87.66	20.93	75	7312	105823	79631178
Intraocular pressure increased	84.92	20.93	32	7355	9173	79727828
Bacterial endophthalmitis	80.29	20.93	14	7373	166	79736835
Anaphylactic reaction	79.03	20.93	64	7323	83679	79653322
Lip ulceration	75.42	20.93	21	7366	2304	79734697
Corneal epithelium defect	66.34	20.93	15	7372	704	79736297
Visual impairment	65.73	20.93	60	7327	92071	79644930
Procedural pain	65.05	20.93	35	7352	23049	79713952
Macular oedema	61.48	20.93	22	7365	5452	79731549
Retinal pigment epithelial tear	60.98	20.93	13	7374	463	79736538
Post procedural discomfort	60.83	20.93	15	7372	1025	79735976
Conjunctival oedema	59.23	20.93	15	7372	1143	79735858
Metamorphopsia	57.59	20.93	15	7372	1278	79735723
Tonsillitis	57.10	20.93	22	7365	6692	79730309
Non-infectious endophthalmitis	53.75	20.93	11	7376	320	79736681
Post procedural complication	53.17	20.93	31	7356	23798	79713203
Off label use	51.48	20.93	192	7195	907023	78829978
Blindness	50.66	20.93	32	7355	28351	79708650
Retinal haemorrhage	49.46	20.93	21	7366	8196	79728805
Corneal abrasion	48.61	20.93	13	7374	1226	79735775
Corneal infiltrates	48.56	20.93	10	7377	300	79736701
Anaphylactic shock	48.35	20.93	34	7353	35962	79701039
Transmission of an infectious agent via product	46.65	20.93	9	7378	192	79736809
Parophthalmia	46.10	20.93	10	7377	387	79736614
Suspected transmission of an infectious agent via product	44.44	20.93	12	7375	1174	79735827
Oliguria	43.92	20.93	24	7363	16285	79720716
Product contamination microbial	42.25	20.93	11	7376	935	79736066
Anterior chamber flare	42.10	20.93	8	7379	157	79736844
Eye oedema	42.06	20.93	13	7374	2050	79734951
Cataract nuclear	41.16	20.93	11	7376	1035	79735966
Eye irritation	38.62	20.93	24	7363	20657	79716344
Conjunctivitis	38.56	20.93	26	7361	25689	79711312
Vitreous disorder	38.44	20.93	8	7379	253	79736748
Urine iodine increased	37.97	20.93	5	7382	5	79736996
Multiple use of single-use product	37.70	20.93	10	7377	914	79736087
Foreign body sensation in eyes	37.35	20.93	12	7375	2145	79734856
Ocular hypertension	37.09	20.93	11	7376	1509	79735492
Toxic skin eruption	36.97	20.93	24	7363	22269	79714732
Vitreous detachment	36.81	20.93	12	7375	2247	79734754
Conjunctival hyperaemia	35.89	20.93	14	7373	4399	79732602
Iridocyclitis	34.60	20.93	13	7374	3691	79733310
Vitreous haemorrhage	34.57	20.93	13	7374	3700	79733301
Post procedural infection	34.15	20.93	18	7369	11366	79725635
Ocular toxicity	33.41	20.93	9	7378	872	79736129
Anterior chamber inflammation	32.17	20.93	8	7379	566	79736435
Cataract operation complication	31.71	20.93	7	7380	294	79736707
Genital haemorrhage	31.18	20.93	14	7373	6241	79730760
Vitreous opacities	30.88	20.93	8	7379	667	79736334
Blindness unilateral	30.61	20.93	15	7372	8131	79728870
Eye infection bacterial	30.29	20.93	7	7380	362	79736639
Cystoid macular oedema	30.18	20.93	10	7377	1970	79735031
Anterior chamber disorder	29.96	20.93	6	7381	156	79736845
Retinal disorder	29.85	20.93	10	7377	2037	79734964
Lacrimation increased	29.64	20.93	21	7366	22456	79714545
Pseudoendophthalmitis	29.45	20.93	5	7382	50	79736951
Retinal scar	29.26	20.93	7	7380	421	79736580
Swollen tongue	28.92	20.93	27	7360	42543	79694458
Ophthalmological examination abnormal	28.25	20.93	5	7382	65	79736936
Retinal oedema	28.05	20.93	8	7379	957	79736044
Poor quality product administered	27.67	20.93	11	7376	3634	79733367
Corneal opacity	27.61	20.93	8	7379	1012	79735989
Exophthalmos	27.42	20.93	9	7378	1721	79735280
Haemorrhoids thrombosed	27.30	20.93	6	7381	247	79736754
Photopsia	26.78	20.93	12	7375	5324	79731677
Maculopathy	26.70	20.93	10	7377	2815	79734186
Eye pruritus	26.62	20.93	19	7368	20551	79716450
Delayed delivery	25.51	20.93	4	7383	23	79736978
Balanitis candida	25.31	20.93	5	7382	121	79736880
Keratic precipitates	25.14	20.93	6	7381	357	79736644
Device expulsion	24.86	20.93	20	7367	25841	79711160
Photophobia	24.38	20.93	18	7369	20510	79716491
Fatigue	23.66	20.93	31	7356	929696	78807305
Retinal detachment	23.22	20.93	13	7374	9234	79727767
Dermatitis bullous	22.79	20.93	15	7372	14230	79722771
Enterocutaneous fistula	22.47	20.93	8	7379	1953	79735048
Retinopathy of prematurity	21.57	20.93	3	7384	6	79736995
Ocular discomfort	21.22	20.93	10	7377	4973	79732028
Macular fibrosis	21.04	20.93	6	7381	717	79736284

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AG02	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products
ATC	D09AA09	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D11AC06	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Medicated shampoos
ATC	G01AX11	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Other antiinfectives and antiseptics
ATC	R02AA15	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
ATC	S01AX18	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
FDA CS	M0011640	Iodine
FDA EPC	N0000175486	Antiseptic
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bacterial septicemia	contraindication	10001005	DOID:0040085
Shock	contraindication	27942005
Decreased respiratory function	contraindication	80954004
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019273	VUID
N0000147472	NUI
D00863	KEGG_DRUG
4018171	VANDF
4019273	VANDF
C0032857	UMLSCUI
CHEBI:8347	CHEBI
CHEMBL1201724	ChEMBL_ID
D011206	MESH_DESCRIPTOR_UI
DB06812	DRUGBANK_ID
85H0HZU99M	UNII
410087	PUBCHEM_CID
8611	RXNORM
1871	MMSL
5338	MMSL
003153	NDDF
111144003	SNOMEDCT_US
386989006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Betadine	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0411	SOLUTION	5 mg	OPHTHALMIC	NDA	16 sections
Betadine	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0411	SOLUTION	5 mg	OPHTHALMIC	NDA	16 sections
SUMMERS EVE	HUMAN OTC DRUG LABEL	1	0132-8743	DOUCHE	4 g	VAGINAL	OTC MONOGRAPH NOT FINAL	12 sections
SUMMERS EVE	HUMAN OTC DRUG LABEL	1	0132-8743	DOUCHE	4 g	VAGINAL	OTC MONOGRAPH NOT FINAL	12 sections
First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0363-0777	SOLUTION	10 mg	TOPICAL	OTC monograph not final	13 sections
First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0363-0777	SOLUTION	10 mg	TOPICAL	OTC monograph not final	13 sections
Apothecary PVP Topical	HUMAN OTC DRUG LABEL	1	0363-0939	SOLUTION	1 g	TOPICAL	OTC monograph not final	11 sections
Humco Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-2325	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Humco Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-2325	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9123	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9123	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9128	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9128	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9128	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9129	LIQUID	50 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9129	LIQUID	50 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9129	LIQUID	50 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9136	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9136	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Henry Schein Povidone-Iodine Swabsticks	HUMAN OTC DRUG LABEL	1	0404-0119	SWAB	1 g	TOPICAL	OTC monograph not final	13 sections
Henry Schein Povidone-Iodine Prep Pad	HUMAN OTC DRUG LABEL	1	0404-0121	SWAB	1 g	TOPICAL	OTC monograph not final	10 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5637	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5638	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5639	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
North PVP Iodine Swabs	HUMAN OTC DRUG LABEL	1	0498-0118	SOLUTION	0.01 g	TOPICAL	unapproved drug other	14 sections
North PVP Iodine Swabs	HUMAN OTC DRUG LABEL	1	0498-0118	SOLUTION	0.01 g	TOPICAL	unapproved drug other	14 sections
North PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0120	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections
North PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0120	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections
PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0121	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections
PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0121	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections