pyrithione zinc 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4248	13463-41-7

Description:

Molecule	Description
Synonyms: pyrithione zinc zinc pyrithione	dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon; antifungal and antibacterial Molecular weight: 317.69 Formula: C10H8N2O2S2Zn CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

pyrithione zinc
zinc pyrithione

dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon; antifungal and antibacterial

Molecular weight: 317.69
Formula: C10H8N2O2S2Zn
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	521.42	13.30	191	21477	13631	63453723
Creatinine renal clearance decreased	494.22	13.30	192	21476	16116	63451238
Blood calcium decreased	429.48	13.30	200	21468	26251	63441103
Orthostatic hypotension	364.66	13.30	198	21470	35962	63431392
Sedation	359.72	13.30	201	21467	38608	63428746
Cognitive disorder	323.59	13.30	214	21454	55601	63411753
Balance disorder	273.36	13.30	228	21440	84194	63383160
Depressed level of consciousness	264.18	13.30	197	21471	61881	63405473
Mobility decreased	215.54	13.30	235	21433	120924	63346430
Constipation	203.54	13.30	312	21356	224631	63242723
COVID-19	119.55	13.30	169	21499	112934	63354420
Fall	98.84	13.30	326	21342	392008	63075346
Hypotension	74.40	13.30	233	21435	272371	63194983
Toxicity to various agents	59.03	13.30	202	21466	247048	63220306
Pain	57.48	13.30	440	21228	740188	62727166
Contraindicated product administered	53.29	13.30	6	21662	217642	63249712
Illness	49.84	13.30	72	21596	48987	63418367
Pulmonary pain	49.28	13.30	24	21644	3466	63463888
Synovitis	48.80	13.30	4	21664	186914	63280440
Necrosis ischaemic	44.31	13.30	15	21653	845	63466509
Systemic lupus erythematosus	43.76	13.30	9	21659	208909	63258445
Multiple drug therapy	42.45	13.30	22	21646	3624	63463730
Salpingo-oophorectomy unilateral	40.08	13.30	14	21654	867	63466487
Maternal exposure during pregnancy	37.67	13.30	14	21654	220048	63247306
Aplastic anaemia	37.61	13.30	29	21639	9540	63457814
Amyloid arthropathy	37.46	13.30	12	21656	568	63466786
Glossodynia	36.86	13.30	8	21660	178868	63288486
Drug ineffective	36.43	13.30	209	21459	1044556	62422798
Beta haemolytic streptococcal infection	34.97	13.30	16	21652	2009	63465345
Pneumonia streptococcal	33.46	13.30	15	21653	1796	63465558
Sinusitis fungal	33.30	13.30	15	21653	1816	63465538
Product dose omission issue	32.49	13.30	162	21506	234151	63233203
Skin odour abnormal	31.42	13.30	14	21654	1652	63465702
Copper deficiency	31.19	13.30	7	21661	81	63467273
Nasal polyps	29.82	13.30	21	21647	6018	63461336
Death	29.16	13.30	52	21616	374329	63093025
Sputum increased	29.09	13.30	15	21653	2444	63464910
Dermatitis atopic	28.81	13.30	25	21643	9699	63457655
Eczema	27.96	13.30	44	21624	32247	63435107
Wound secretion	27.43	13.30	18	21650	4596	63462758
Respiratory symptom	27.38	13.30	16	21652	3331	63464023
Lipoedema	27.02	13.30	8	21660	290	63467064
Arthritis infective	26.27	13.30	20	21648	6458	63460896
Embolism venous	25.60	13.30	15	21653	3139	63464215
Spinal cord disorder	24.92	13.30	11	21657	1270	63466084
White blood cell count decreased	24.32	13.30	103	21565	139001	63328353
Norovirus infection	24.29	13.30	9	21659	661	63466693
Diastolic dysfunction	24.11	13.30	19	21649	6452	63460902
Acquired diaphragmatic eventration	23.74	13.30	8	21660	444	63466910
Rhinocerebral mucormycosis	23.52	13.30	8	21660	457	63466897
Infrapatellar fat pad inflammation	21.79	13.30	6	21662	167	63467187
Acute kidney injury	21.02	13.30	36	21632	263379	63203975
Discomfort	20.80	13.30	16	21652	167358	63299996
Procedural complication	20.33	13.30	16	21652	5423	63461931
Fistula discharge	20.03	13.30	9	21659	1084	63466270
Rheumatoid arthritis	19.97	13.30	35	21633	253784	63213570
Wound	19.79	13.30	16	21652	163247	63304107
Female genital tract fistula	19.55	13.30	18	21650	7541	63459813
Feeling abnormal	19.42	13.30	101	21567	148291	63319063
Terminal insomnia	19.40	13.30	8	21660	781	63466573
Yellow skin	18.92	13.30	11	21657	2269	63465085
Infusion site extravasation	18.09	13.30	20	21648	10406	63456948
Cardiac arrest	17.39	13.30	5	21663	92540	63374814
Emphysema	17.31	13.30	20	21648	10918	63456436
Heart rate variability increased	17.12	13.30	4	21664	56	63467298
Eyelid margin crusting	17.05	13.30	8	21660	1064	63466290
Treatment failure	17.00	13.30	26	21642	199017	63268337
Gastrointestinal candidiasis	16.69	13.30	5	21663	189	63467165
Haemorrhagic diathesis	16.52	13.30	13	21655	4402	63462952
Chondropathy	16.23	13.30	10	21658	2290	63465064
Disease recurrence	16.22	13.30	32	21636	27998	63439356
Effusion	16.17	13.30	9	21659	1709	63465645
Hysterectomy	16.10	13.30	18	21650	9481	63457873
Seasonal allergy	16.04	13.30	27	21641	20923	63446431
Candida infection	15.96	13.30	32	21636	28319	63439035
Fear of falling	15.77	13.30	6	21662	474	63466880
Endometrial cancer	15.43	13.30	11	21657	3214	63464140
Product use in unapproved indication	15.23	13.30	109	21559	178971	63288383
Chest discomfort	15.19	13.30	76	21592	109893	63357461
Product use issue	15.10	13.30	33	21635	220487	63246867
Blood smear test abnormal	14.90	13.30	4	21664	101	63467253
Confusional state	14.88	13.30	37	21631	236343	63231011
Sneezing	14.64	13.30	24	21644	18194	63449160
Joint swelling	14.53	13.30	60	21608	327606	63139748
Thinking abnormal	14.45	13.30	18	21650	10625	63456729
Ocular icterus	14.19	13.30	11	21657	3645	63463709
Cough	13.95	13.30	157	21511	292586	63174768
Product dose omission in error	13.90	13.30	15	21653	7597	63459757
General physical health deterioration	13.90	13.30	30	21638	201372	63265982
Multiple allergies	13.64	13.30	20	21648	13782	63453572
Oral pain	13.60	13.30	30	21638	28364	63438990
Fungal infection	13.40	13.30	35	21633	36839	63430515

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	78.37	15.01	236	7500	419288	34529907
Rhinocerebral mucormycosis	56.87	15.01	15	7721	553	34948642
COVID-19	54.48	15.01	76	7660	77474	34871721
Radiation inflammation	41.46	15.01	13	7723	892	34948303
Pulmonary pain	37.61	15.01	13	7723	1211	34947984
Product dose omission issue	33.99	15.01	79	7657	119632	34829563
Fatigue	25.37	15.01	154	7582	370499	34578696
Aplastic anaemia	22.41	15.01	18	7718	9698	34939497
Sinusitis	18.49	15.01	33	7703	41369	34907826
Vascular device infection	17.15	15.01	11	7725	4174	34945021
Metal poisoning	16.97	15.01	4	7732	92	34949103
Arthropathy	16.85	15.01	25	7711	26882	34922313
Toxicity to various agents	16.72	15.01	12	7724	200350	34748845
Copper deficiency	16.14	15.01	3	7733	20	34949175
Illness	15.53	15.01	17	7719	13512	34935683

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	535.81	12.70	195	23864	15474	79704855
Creatinine renal clearance decreased	502.74	12.70	196	23863	18806	79701523
Blood calcium decreased	436.03	12.70	206	23853	31613	79688716
Sedation	338.69	12.70	205	23854	51690	79668639
Orthostatic hypotension	321.26	12.70	204	23855	55960	79664369
Cognitive disorder	315.36	12.70	219	23840	69707	79650622
Balance disorder	260.29	12.70	225	23834	98632	79621697
Mobility decreased	232.44	12.70	232	23827	121943	79598386
Depressed level of consciousness	212.94	12.70	199	23860	96453	79623876
Constipation	182.66	12.70	315	23744	282735	79437594
COVID-19	146.98	12.70	208	23851	157466	79562863
Pain	88.18	12.70	432	23627	703370	79016959
Pulmonary pain	86.89	12.70	37	24022	4436	79715893
Fall	80.37	12.70	325	23734	487304	79233025
Rhinocerebral mucormycosis	75.71	12.70	23	24036	1035	79719294
Hypotension	53.31	12.70	268	23791	440049	79280280
Product dose omission issue	53.26	12.70	180	23879	247357	79472972
Aplastic anaemia	49.57	12.70	42	24017	17863	79702466
Off label use	48.10	12.70	450	23609	906765	78813564
Illness	47.21	12.70	64	23995	46447	79673882
Copper deficiency	44.30	12.70	10	24049	136	79720193
Multiple drug therapy	42.68	12.70	22	24037	4056	79716273
Necrosis ischaemic	42.64	12.70	15	24044	1075	79719254
Salpingo-oophorectomy unilateral	42.52	12.70	14	24045	820	79719509
Nasal polyps	40.31	12.70	26	24033	7301	79713028
Amyloid arthropathy	38.91	12.70	12	24047	568	79719761
Radiation inflammation	37.50	12.70	13	24046	892	79719437
Synovitis	34.36	12.70	3	24056	150731	79569598
Beta haemolytic streptococcal infection	33.13	12.70	15	24044	2082	79718247
Skin odour abnormal	32.83	12.70	15	24044	2126	79718203
Sinusitis fungal	31.35	12.70	15	24044	2359	79717970
Acute kidney injury	29.65	12.70	71	23988	519333	79200996
Pneumonia streptococcal	29.28	12.70	15	24044	2730	79717599
Drug ineffective	29.16	12.70	199	23860	1080714	78639615
Contraindicated product administered	27.16	12.70	7	24052	157531	79562798
Sputum increased	26.94	12.70	17	24042	4596	79715733
Acquired diaphragmatic eventration	25.53	12.70	9	24050	649	79719680
Female genital tract fistula	25.23	12.70	18	24041	5957	79714372
Toxicity to various agents	25.22	12.70	215	23844	421325	79299004
Arthritis infective	24.13	12.70	20	24039	8251	79712078
Respiratory symptom	23.92	12.70	16	24043	4775	79715554
Embolism venous	23.21	12.70	15	24044	4224	79716105
Infrapatellar fat pad inflammation	22.52	12.70	6	24053	167	79720162
Wound secretion	22.42	12.70	17	24042	6171	79714158
Eczema	21.86	12.70	42	24017	40776	79679553
Systemic lupus erythematosus	21.63	12.70	5	24054	121144	79599185
Pericarditis	21.42	12.70	3	24056	104233	79616096
Norovirus infection	21.24	12.70	8	24051	696	79719633
Oral pain	21.22	12.70	36	24023	31762	79688567
Lipoedema	21.04	12.70	6	24053	216	79720113
Coma	20.44	12.70	3	24056	100646	79619683
Hysterectomy	20.05	12.70	16	24043	6256	79714073
Intentional overdose	19.67	12.70	4	24055	105956	79614373
Taste disorder	19.54	12.70	24	24035	15799	79704530
Diastolic dysfunction	19.54	12.70	20	24039	10791	79709538
Chest discomfort	19.52	12.70	88	23971	137956	79582373
Fistula discharge	19.15	12.70	9	24050	1359	79718970
Sinusitis	18.86	12.70	112	23947	195389	79524940
Infusion site extravasation	18.81	12.70	19	24040	10089	79710240
Disease recurrence	18.46	12.70	41	24018	44068	79676261
Death	17.97	12.70	99	23960	566415	79153914
Heart rate variability increased	17.55	12.70	4	24055	57	79720272
Seasonal allergy	17.29	12.70	23	24036	16383	79703946
Feeling abnormal	17.19	12.70	94	23965	159105	79561224
Cardiac failure	17.11	12.70	13	24046	154829	79565500
Maternal exposure during pregnancy	17.06	12.70	10	24049	136528	79583801
Terminal insomnia	17.02	12.70	8	24051	1209	79719120
White blood cell count decreased	16.98	12.70	106	23953	188182	79532147
Spinal cord disorder	16.65	12.70	9	24050	1826	79718503
Chondropathy	16.56	12.70	10	24049	2502	79717827
General physical health deterioration	16.17	12.70	37	24022	275201	79445128
Sinus disorder	15.74	12.70	26	24033	22438	79697891
Endometrial cancer	15.54	12.70	9	24050	2085	79718244
Sneezing	15.46	12.70	24	24035	19659	79700670
Dermatitis atopic	15.34	12.70	17	24042	10039	79710290
Fatigue	15.16	12.70	377	23682	929350	78790979
Opportunistic infection	15.08	12.70	10	24049	2940	79717389
Effusion	15.08	12.70	9	24050	2205	79718124
Eyelid margin crusting	14.93	12.70	7	24052	1052	79719277
SARS-CoV-2 test positive	14.84	12.70	18	24041	11698	79708631
Multiple allergies	14.79	12.70	17	24042	10443	79709886
Drug interaction	14.59	12.70	70	23989	415113	79305216
Emphysema	14.41	12.70	21	24038	16279	79704050
Fear of falling	14.33	12.70	6	24053	689	79719640
Rhinorrhoea	14.33	12.70	53	24006	76021	79644308
Angioedema	13.85	12.70	3	24056	76032	79644297
Hiatus hernia	13.75	12.70	25	24034	23287	79697042
Tenderness	13.49	12.70	25	24034	23617	79696712
Gastrointestinal candidiasis	13.34	12.70	5	24054	429	79719900
Myocardial infarction	13.20	12.70	22	24037	184107	79536222
Sleep apnoea syndrome	13.17	12.70	32	24027	36446	79683883
Headache	13.10	12.70	273	23786	653499	79066830
Procedural complication	13.05	12.70	14	24045	7969	79712360
Neutropenia	12.95	12.70	44	24015	287666	79432663
Dysphoria	12.89	12.70	11	24048	4723	79715606
Spleen atrophy	12.78	12.70	3	24056	49	79720280

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D11AX12	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D007641	Keratolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Seborrheic dermatitis	indication	50563003	DOID:8741
Pityriasis simplex	indication	200767005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.21	CHEMBL
Potassium voltage-gated channel subfamily KQT member 2	Ion channel	O43526	KCNQ2_HUMAN	ACTIVATOR	EC50	5.80	IUPHAR
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	5.76	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	5.27	CHEMBL
Potassium voltage-gated channel subfamily KQT member 1	Ion channel	P51787	KCNQ1_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	5.29	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	5.45	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	5.11	CHEMBL
Potassium voltage-gated channel subfamily KQT member 5	Ion channel	Q9NR82	KCNQ5_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	5.79	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	5.62	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	5.54	CHEMBL
Potassium voltage-gated channel subfamily KQT member 4	Ion channel	P56696	KCNQ4_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Ki	5.38	CHEMBL

External reference:

ID	Source
4020508	VUID
N0000179286	NUI
D01938	KEGG_DRUG
4019187	VANDF
4020508	VANDF
C0078792	UMLSCUI
CHEBI:32076	CHEBI
CHEMBL3392049	ChEMBL_ID
CHEMBL1200471	ChEMBL_ID
C010423	MESH_SUPPLEMENTAL_RECORD_UI
2597	IUPHAR_LIGAND_ID
2295	INN_ID
R953O2RHZ5	UNII
3729132	PUBCHEM_CID
39952	RXNORM
4999	MMSL
5397	MMSL
002961	NDDF
255954005	SNOMEDCT_US
411297004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DHS ZINC	HUMAN OTC DRUG LABEL	1	0096-0735	SHAMPOO	20 mg	TOPICAL	OTC monograph final	8 sections
DHS ZINC	HUMAN OTC DRUG LABEL	1	0096-0735	SHAMPOO	20 mg	TOPICAL	OTC monograph final	8 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0363-0253	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0363-0253	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0363-0253	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dry Scalp Care	HUMAN OTC DRUG LABEL	1	0363-0688	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dry Scalp Care	HUMAN OTC DRUG LABEL	1	0363-0688	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	0363-0755	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	0363-0755	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	0363-0755	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
Walgreens Dandruff Itchy Dry Scalp Defense Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4138	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
Walgreens Dandruff Conditioner 2 in 1 Itchy Scalp Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4288	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
Walgreens Dandruff Conditioner 2 in 1 Itchy Scalp Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4289	SHAMPOO	10 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Walgreens Dandruff Plus Conditioner 2 in 1 Dry Scalp Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4666	SHAMPOO	10 mg	TOPICAL	OTC monograph final	13 sections
Walgreens Dandruff Plus Conditioner 2 in 1 Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4673	SHAMPOO	10 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0869-0153	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0869-0153	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	0869-0153	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Satinique Anti Dandruff	HUMAN OTC DRUG LABEL	1	10056-006	CREAM	9.50 mg	TOPICAL	OTC monograph final	9 sections
Advance Techniques Keep ClearAnti-Dandruff Treatment	HUMAN OTC DRUG LABEL	1	10096-0220	LOTION	0.15 mL	TOPICAL	OTC monograph final	20 sections
Advance Techniques Keep Clear2-in-1 Anti-Dandruff	HUMAN OTC DRUG LABEL	1	10096-0221	SHAMPOO	10 mg	TOPICAL	OTC monograph final	11 sections
American Crew	HUMAN OTC DRUG LABEL	1	10967-650	SHAMPOO	1 mg	TOPICAL	OTC monograph final	8 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-253	SHAMPOO	10 mg	TOPICAL	OTC monograph final	11 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-253	SHAMPOO	10 mg	TOPICAL	OTC monograph final	11 sections
Fresh Mint Dandruff	HUMAN OTC DRUG LABEL	1	11344-309	SHAMPOO	1 kg	TOPICAL	OTC monograph final	10 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	11344-311	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	11344-311	SHAMPOO	10 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-443	SHAMPOO	10.40 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-443	SHAMPOO	10.40 mg	TOPICAL	OTC monograph final	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-475	SHAMPOO	1 mg	TOPICAL	OTC monograph final	12 sections