Polymyxin B 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4246 1405-20-5

Description:

MoleculeDescription

Synonyms:

  • Polymyxin B sulfate
  • aerosporin
  • mastimyxin
  • Polymyxin B
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
  • Molecular weight: 2392.97
  • Formula: C111H194N32O26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 490.66
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 MU O
0.15 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 26, 1957 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 333.71 17.09 229 4280 310458 63174055
Macular degeneration 284.16 17.09 94 4415 24282 63460231
Drug ineffective 44.49 17.09 168 4341 1044597 62439916
Respiratory failure 37.49 17.09 41 4468 101817 63382696
Cytomegalovirus test positive 32.55 17.09 11 4498 3007 63481506
Septic arthritis staphylococcal 30.42 17.09 7 4502 466 63484047
Lymphatic disorder 26.44 17.09 6 4503 375 63484138
Chronic sinusitis 25.17 17.09 14 4495 12829 63471684
Sepsis 23.07 17.09 40 4469 153083 63331430
Engraft failure 21.33 17.09 5 4504 361 63484152
Procedural pain 20.78 17.09 15 4494 21554 63462959
Paraesthesia oral 19.95 17.09 14 4495 19242 63465271

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 38.20 17.56 46 3863 80483 34872539
Respiratory paralysis 33.29 17.56 6 3903 71 34952951
Mucosal disorder 29.68 17.56 10 3899 1716 34951306
Disseminated intravascular coagulation 28.87 17.56 22 3887 21794 34931228
Chronic graft versus host disease 23.75 17.56 11 3898 4362 34948660
Pathogen resistance 20.66 17.56 13 3896 9469 34943553
Hepatic function abnormal 20.45 17.56 25 3884 44338 34908684
Trichosporon infection 19.84 17.56 6 3903 728 34952294
Drug resistance 19.65 17.56 19 3890 25908 34927114
Bacterial translocation 19.15 17.56 5 3904 355 34952667
Sepsis 19.13 17.56 51 3858 166510 34786512
Acute graft versus host disease in skin 19.04 17.56 10 3899 5191 34947831
Multiple organ dysfunction syndrome 18.82 17.56 32 3877 76534 34876488
Engraftment syndrome 18.03 17.56 6 3903 991 34952031

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 175.19 15.45 172 7020 298744 79438452
Respiratory failure 42.72 15.45 66 7126 180845 79556351
Drug resistance 39.99 15.45 32 7160 42181 79695015
Cytomegalovirus test positive 38.88 15.45 16 7176 5931 79731265
Respiratory paralysis 33.78 15.45 6 7186 82 79737114
Sepsis 32.88 15.45 74 7118 269354 79467842
Pathogen resistance 30.71 15.45 18 7174 14324 79722872
Engraftment syndrome 29.47 15.45 9 7183 1400 79735796
Disseminated intravascular coagulation 29.41 15.45 25 7167 35817 79701379
Macular degeneration 29.10 15.45 16 7176 11280 79725916
Multiple organ dysfunction syndrome 27.15 15.45 43 7149 120203 79616993
Lymphatic disorder 25.69 15.45 6 7186 334 79736862
Hepatic function abnormal 25.19 15.45 32 7160 73075 79664121
Septic arthritis staphylococcal 25.01 15.45 7 7185 804 79736392
Paraesthesia oral 24.85 15.45 18 7174 20453 79716743
Renal injury 23.13 15.45 16 7176 16911 79720285
Chronic graft versus host disease 21.41 15.45 11 7181 6770 79730426
Febrile neutropenia 21.30 15.45 57 7135 230942 79506254
Slow response to stimuli 19.42 15.45 7 7185 1818 79735378
Trichosporon infection 19.23 15.45 6 7186 1002 79736194
Drug interaction 18.77 15.45 7 7185 415176 79322020
Procedural pain 18.72 15.45 16 7176 23068 79714128
Mucosal disorder 18.12 15.45 8 7184 3520 79733676
Skin hyperpigmentation 17.87 15.45 10 7182 7293 79729903
Pyrexia 17.68 15.45 113 7079 678596 79058600
Bacterial translocation 17.20 15.45 5 7187 657 79736539
Vaginal flatulence 17.08 15.45 7 7185 2568 79734628
Chronic sinusitis 17.07 15.45 12 7180 13014 79724182
Platelet count decreased 16.90 15.45 47 7145 194617 79542579
Mental status changes 16.58 15.45 25 7167 66934 79670262
Tachypnoea 16.02 15.45 17 7175 32046 79705150
Unevaluable event 15.57 15.45 22 7170 55563 79681633

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA05 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XB02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Polymyxins
ATC S01AA18 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA11 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0017217 Polymyxins
FDA EPC N0000175499 Polymyxin-class Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Bacterial septicemia indication 10001005 DOID:0040085
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Corneal abrasion indication 85848002
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication
Minor Bacterial Skin Infections indication
Minor Skin Wound Pain indication
Mastoidectomy Cavity Infections indication
H. Influenzae Meningitis indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Meibomianitis off-label use 309779001
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Herpes zoster auricularis contraindication 21954000 DOID:9210
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Dehydration contraindication 34095006
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Neuromuscular block, function contraindication 55394004
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Procedure on urinary system contraindication 118677009
Open wound contraindication 125643001
Eye infection contraindication 128351009
Hearing disorder contraindication 128540005
Bacterial infection of eye contraindication 128984004
Tuberculosis of ear contraindication 186269001
Telangiectasia disorder contraindication 247479008
Rupture of bladder contraindication 251925007
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Vaccinia keratitis contraindication 397552005
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation associated with topical ophthalmological conditions of the eye Indication
Cats Edema associated with topical ophthalmological conditions of the eye Indication
Cats Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Cattle Superficial ocular infections Indication
Cattle Infections caused by streptococci Indication
Cattle Infections caused by rickettsiae Indication
Cattle Infections caused by Escherichia coli Indication
Cattle Infections caused by A aerogenes Indication
Dogs Inflammation associated with topical ophthalmological conditions of the eye Indication
Dogs Edema associated with topical ophthalmological conditions of the eye Indication
Dogs Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Horses Inflammation associated with topical ophthalmological conditions of the eye Indication
Horses Edema associated with topical ophthalmological conditions of the eye Indication
Horses Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Sheep Inflammation associated with topical ophthalmological conditions of the eye Indication
Sheep Edema associated with topical ophthalmological conditions of the eye Indication
Sheep Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication

🐶 Veterinary products

ProductApplicantIngredients
Terramycin Ophthalmic Ointment with Polymyxin Zoetis Inc. 2
Anaprime Ophthalmic Solution Zoetis Inc. 3
Anaprime Opthakote Ophthalmic Zoetis Inc. 3
Optiprime Opthakote Ophthalmic Solution Zoetis Inc. 2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment Dechra, Ltd. 4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment Dechra, Ltd. 3
Mycitracin Sterile Ophthalmic Ointment Zoetis Inc. 3
Forte Topical Ointment Zoetis Inc. 4
Cortisporin Veterinary Ophthalmic Ointment Intervet Inc. 4
Neosporin Ophthalmic Ointment Intervet Inc. 3
Surolan Elanco US Inc. 3
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment Akorn Animal Health Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018100 VUID
N0000146438 NUI
D08401 KEGG_DRUG
4018100 VANDF
4018594 VANDF
C0032535 UMLSCUI
CHEBI:8310 CHEBI
CHEMBL3989738 ChEMBL_ID
CHEMBL3989714 ChEMBL_ID
D011112 MESH_DESCRIPTOR_UI
DB00781 DRUGBANK_ID
10338 IUPHAR_LIGAND_ID
490 INN_ID
J2VZ07J96K UNII
202404 RXNORM
1703 MMSL
5317 MMSL
5318 MMSL
d00344 MMSL
002803 NDDF
004902 NDDF
372824005 SNOMEDCT_US
61360007 SNOMEDCT_US
6960003 SNOMEDCT_US
1404-26-8 SECONDARY_CAS_RN
4868 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 100000 [USPU] OPHTHALMIC NDA 19 sections
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 100000 [USPU] OPHTHALMIC NDA 19 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0065-0631 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
Maxitrol HUMAN PRESCRIPTION DRUG LABEL 3 0078-0792 SUSPENSION 10000 [USPU] OPHTHALMIC NDA 18 sections
Good Sense First Aid Antibiotic HUMAN OTC DRUG LABEL 3 0113-0084 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 13 sections
Good Sense Triple Antibioticand Pain Relief HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
basic care first aid antibiotic HUMAN OTC DRUG LABEL 3 0113-0701 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 13 sections
good sense triple antibiotic HUMAN OTC DRUG LABEL 4 0113-1140 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Basic Care First Aid Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0113-7679 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Polymyxin B HUMAN PRESCRIPTION DRUG LABEL 1 0143-9941 INJECTION, POWDER, FOR SOLUTION 500000 [iU] INTRAMUSCULAR ANDA 14 sections
Bacitracin Zinc and Polymyxin B Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0168-0273 OINTMENT 10000 1 OPHTHALMIC ANDA 17 sections
Kaiser PermanenteDouble antibiotic HUMAN OTC DRUG LABEL 2 0179-8707 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 14 sections
AntibioticMaximum Strength HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 10000 [iU] TOPICAL OTC monograph final 13 sections
AntibioticMaximum Strength HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 10000 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic with Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 10000 [USPU] TOPICAL OTC MONOGRAPH FINAL 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 5000 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 5000 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 5000 [iU] TOPICAL OTC monograph final 13 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC monograph final 15 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections
Walgreens Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-2016 OINTMENT 5000 [iU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Walgreens Kids Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2122 CREAM 10000 [USPU] TOPICAL OTC monograph not final 11 sections
Walgreens Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2123 CREAM 10000 [USPU] TOPICAL OTC monograph not final 9 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 4 0363-2900 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 13 sections