Stem definition | Drug id | CAS RN |
---|---|---|
4246 | 1405-20-5 |
Molecule | Description |
---|---|
Synonyms:
|
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
|
Dose | Unit | Route |
---|---|---|
3 | MU | O |
0.15 | g | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 26, 1957 | FDA | MONARCH PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 333.71 | 17.09 | 229 | 4280 | 310458 | 63174055 |
Macular degeneration | 284.16 | 17.09 | 94 | 4415 | 24282 | 63460231 |
Drug ineffective | 44.49 | 17.09 | 168 | 4341 | 1044597 | 62439916 |
Respiratory failure | 37.49 | 17.09 | 41 | 4468 | 101817 | 63382696 |
Cytomegalovirus test positive | 32.55 | 17.09 | 11 | 4498 | 3007 | 63481506 |
Septic arthritis staphylococcal | 30.42 | 17.09 | 7 | 4502 | 466 | 63484047 |
Lymphatic disorder | 26.44 | 17.09 | 6 | 4503 | 375 | 63484138 |
Chronic sinusitis | 25.17 | 17.09 | 14 | 4495 | 12829 | 63471684 |
Sepsis | 23.07 | 17.09 | 40 | 4469 | 153083 | 63331430 |
Engraft failure | 21.33 | 17.09 | 5 | 4504 | 361 | 63484152 |
Procedural pain | 20.78 | 17.09 | 15 | 4494 | 21554 | 63462959 |
Paraesthesia oral | 19.95 | 17.09 | 14 | 4495 | 19242 | 63465271 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 38.20 | 17.56 | 46 | 3863 | 80483 | 34872539 |
Respiratory paralysis | 33.29 | 17.56 | 6 | 3903 | 71 | 34952951 |
Mucosal disorder | 29.68 | 17.56 | 10 | 3899 | 1716 | 34951306 |
Disseminated intravascular coagulation | 28.87 | 17.56 | 22 | 3887 | 21794 | 34931228 |
Chronic graft versus host disease | 23.75 | 17.56 | 11 | 3898 | 4362 | 34948660 |
Pathogen resistance | 20.66 | 17.56 | 13 | 3896 | 9469 | 34943553 |
Hepatic function abnormal | 20.45 | 17.56 | 25 | 3884 | 44338 | 34908684 |
Trichosporon infection | 19.84 | 17.56 | 6 | 3903 | 728 | 34952294 |
Drug resistance | 19.65 | 17.56 | 19 | 3890 | 25908 | 34927114 |
Bacterial translocation | 19.15 | 17.56 | 5 | 3904 | 355 | 34952667 |
Sepsis | 19.13 | 17.56 | 51 | 3858 | 166510 | 34786512 |
Acute graft versus host disease in skin | 19.04 | 17.56 | 10 | 3899 | 5191 | 34947831 |
Multiple organ dysfunction syndrome | 18.82 | 17.56 | 32 | 3877 | 76534 | 34876488 |
Engraftment syndrome | 18.03 | 17.56 | 6 | 3903 | 991 | 34952031 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 175.19 | 15.45 | 172 | 7020 | 298744 | 79438452 |
Respiratory failure | 42.72 | 15.45 | 66 | 7126 | 180845 | 79556351 |
Drug resistance | 39.99 | 15.45 | 32 | 7160 | 42181 | 79695015 |
Cytomegalovirus test positive | 38.88 | 15.45 | 16 | 7176 | 5931 | 79731265 |
Respiratory paralysis | 33.78 | 15.45 | 6 | 7186 | 82 | 79737114 |
Sepsis | 32.88 | 15.45 | 74 | 7118 | 269354 | 79467842 |
Pathogen resistance | 30.71 | 15.45 | 18 | 7174 | 14324 | 79722872 |
Engraftment syndrome | 29.47 | 15.45 | 9 | 7183 | 1400 | 79735796 |
Disseminated intravascular coagulation | 29.41 | 15.45 | 25 | 7167 | 35817 | 79701379 |
Macular degeneration | 29.10 | 15.45 | 16 | 7176 | 11280 | 79725916 |
Multiple organ dysfunction syndrome | 27.15 | 15.45 | 43 | 7149 | 120203 | 79616993 |
Lymphatic disorder | 25.69 | 15.45 | 6 | 7186 | 334 | 79736862 |
Hepatic function abnormal | 25.19 | 15.45 | 32 | 7160 | 73075 | 79664121 |
Septic arthritis staphylococcal | 25.01 | 15.45 | 7 | 7185 | 804 | 79736392 |
Paraesthesia oral | 24.85 | 15.45 | 18 | 7174 | 20453 | 79716743 |
Renal injury | 23.13 | 15.45 | 16 | 7176 | 16911 | 79720285 |
Chronic graft versus host disease | 21.41 | 15.45 | 11 | 7181 | 6770 | 79730426 |
Febrile neutropenia | 21.30 | 15.45 | 57 | 7135 | 230942 | 79506254 |
Slow response to stimuli | 19.42 | 15.45 | 7 | 7185 | 1818 | 79735378 |
Trichosporon infection | 19.23 | 15.45 | 6 | 7186 | 1002 | 79736194 |
Drug interaction | 18.77 | 15.45 | 7 | 7185 | 415176 | 79322020 |
Procedural pain | 18.72 | 15.45 | 16 | 7176 | 23068 | 79714128 |
Mucosal disorder | 18.12 | 15.45 | 8 | 7184 | 3520 | 79733676 |
Skin hyperpigmentation | 17.87 | 15.45 | 10 | 7182 | 7293 | 79729903 |
Pyrexia | 17.68 | 15.45 | 113 | 7079 | 678596 | 79058600 |
Bacterial translocation | 17.20 | 15.45 | 5 | 7187 | 657 | 79736539 |
Vaginal flatulence | 17.08 | 15.45 | 7 | 7185 | 2568 | 79734628 |
Chronic sinusitis | 17.07 | 15.45 | 12 | 7180 | 13014 | 79724182 |
Platelet count decreased | 16.90 | 15.45 | 47 | 7145 | 194617 | 79542579 |
Mental status changes | 16.58 | 15.45 | 25 | 7167 | 66934 | 79670262 |
Tachypnoea | 16.02 | 15.45 | 17 | 7175 | 32046 | 79705150 |
Unevaluable event | 15.57 | 15.45 | 22 | 7170 | 55563 | 79681633 |
None
Source | Code | Description |
---|---|---|
ATC | A07AA05 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics |
ATC | J01XB02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Polymyxins |
ATC | S01AA18 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
ATC | S02AA11 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
ATC | S03AA03 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
FDA CS | M0017217 | Polymyxins |
FDA EPC | N0000175499 | Polymyxin-class Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Keratitis | indication | 5888003 | DOID:4677 |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Urinary tract infectious disease | indication | 68566005 | |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Corneal abrasion | indication | 85848002 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Uveitis | indication | 128473001 | DOID:13141 |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Superficial Ocular Infection | indication | ||
Minor Bacterial Skin Infections | indication | ||
Minor Skin Wound Pain | indication | ||
Mastoidectomy Cavity Infections | indication | ||
H. Influenzae Meningitis | indication | ||
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Dacryocystitis | off-label use | 85777005 | DOID:9938 |
Corneal ulcer | off-label use | 91514001 | DOID:8463 |
Meibomianitis | off-label use | 309779001 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Herpes simplex keratitis | contraindication | 9389005 | |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Bullous myringitis | contraindication | 33528003 | DOID:13791 |
Dehydration | contraindication | 34095006 | |
Severe myopia | contraindication | 34187009 | |
Tuberculosis of eye | contraindication | 49107007 | |
Neuromuscular block, function | contraindication | 55394004 | |
Perforation of tympanic membrane | contraindication | 60442001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Third degree burn injury | contraindication | 80247002 | |
Oliguria | contraindication | 83128009 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Procedure on urinary system | contraindication | 118677009 | |
Open wound | contraindication | 125643001 | |
Eye infection | contraindication | 128351009 | |
Hearing disorder | contraindication | 128540005 | |
Bacterial infection of eye | contraindication | 128984004 | |
Tuberculosis of ear | contraindication | 186269001 | |
Telangiectasia disorder | contraindication | 247479008 | |
Rupture of bladder | contraindication | 251925007 | |
Injury of eye region | contraindication | 282752000 | |
Pregnancy, function | contraindication | 289908002 | |
Viral eye infection | contraindication | 312132001 | |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Vaccinia keratitis | contraindication | 397552005 | |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 |
Species | Use | Relation |
---|---|---|
Cats | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Cats | Edema associated with topical ophthalmological conditions of the eye | Indication |
Cats | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Cattle | Superficial ocular infections | Indication |
Cattle | Infections caused by streptococci | Indication |
Cattle | Infections caused by rickettsiae | Indication |
Cattle | Infections caused by Escherichia coli | Indication |
Cattle | Infections caused by A aerogenes | Indication |
Dogs | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Dogs | Edema associated with topical ophthalmological conditions of the eye | Indication |
Dogs | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Horses | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Horses | Edema associated with topical ophthalmological conditions of the eye | Indication |
Horses | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Inflammation associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Edema associated with topical ophthalmological conditions of the eye | Indication |
Sheep | Secondary bacterial infections associated with topical ophthalmological conditions of the eye | Indication |
Product | Applicant | Ingredients |
---|---|---|
Terramycin Ophthalmic Ointment with Polymyxin | Zoetis Inc. | 2 |
Anaprime Ophthalmic Solution | Zoetis Inc. | 3 |
Anaprime Opthakote Ophthalmic | Zoetis Inc. | 3 |
Optiprime Opthakote Ophthalmic Solution | Zoetis Inc. | 2 |
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment | Dechra, Ltd. | 4 |
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment | Dechra, Ltd. | 3 |
Mycitracin Sterile Ophthalmic Ointment | Zoetis Inc. | 3 |
Forte Topical Ointment | Zoetis Inc. | 4 |
Cortisporin Veterinary Ophthalmic Ointment | Intervet Inc. | 4 |
Neosporin Ophthalmic Ointment | Intervet Inc. | 3 |
Surolan | Elanco US Inc. | 3 |
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment | Akorn Animal Health Inc. | 3 |
None
None
None
None
ID | Source |
---|---|
4018100 | VUID |
N0000146438 | NUI |
D08401 | KEGG_DRUG |
4018100 | VANDF |
4018594 | VANDF |
C0032535 | UMLSCUI |
CHEBI:8310 | CHEBI |
CHEMBL3989738 | ChEMBL_ID |
CHEMBL3989714 | ChEMBL_ID |
D011112 | MESH_DESCRIPTOR_UI |
DB00781 | DRUGBANK_ID |
10338 | IUPHAR_LIGAND_ID |
490 | INN_ID |
J2VZ07J96K | UNII |
202404 | RXNORM |
1703 | MMSL |
5317 | MMSL |
5318 | MMSL |
d00344 | MMSL |
002803 | NDDF |
004902 | NDDF |
372824005 | SNOMEDCT_US |
61360007 | SNOMEDCT_US |
6960003 | SNOMEDCT_US |
1404-26-8 | SECONDARY_CAS_RN |
4868 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 100000 [USPU] | OPHTHALMIC | NDA | 19 sections |
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 100000 [USPU] | OPHTHALMIC | NDA | 19 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0065-0631 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
MAXITROL | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0771 | OINTMENT | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
Maxitrol | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0792 | SUSPENSION | 10000 [USPU] | OPHTHALMIC | NDA | 18 sections |
Good Sense First Aid Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0084 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
basic care first aid antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0701 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Polymyxin B | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9941 | INJECTION, POWDER, FOR SOLUTION | 500000 [iU] | INTRAMUSCULAR | ANDA | 14 sections |
Bacitracin Zinc and Polymyxin B Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0273 | OINTMENT | 10000 1 | OPHTHALMIC | ANDA | 17 sections |
Kaiser PermanenteDouble antibiotic | HUMAN OTC DRUG LABEL | 2 | 0179-8707 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 14 sections |
AntibioticMaximum Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0018 | OINTMENT | 10000 [iU] | TOPICAL | OTC monograph final | 13 sections |
AntibioticMaximum Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0018 | OINTMENT | 10000 [iU] | TOPICAL | OTC monograph final | 13 sections |
Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 10000 [USPU] | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 5000 [iU] | TOPICAL | OTC monograph final | 13 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 5000 [USPU] | TOPICAL | OTC monograph final | 15 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Walgreens Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-2016 | OINTMENT | 5000 [iU] | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
Walgreens Kids Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2122 | CREAM | 10000 [USPU] | TOPICAL | OTC monograph not final | 11 sections |
Walgreens Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2123 | CREAM | 10000 [USPU] | TOPICAL | OTC monograph not final | 9 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 10000 [USPU] | TOPICAL | OTC monograph final | 13 sections |