methyl salicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4245 119-36-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methyl salicylate
  • analgit
  • methyl 2-hydroxybenzoate
  • methyl ester 2-hydroxy benzoic acid
used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990
  • Molecular weight: 152.15
  • Formula: C8H8O3
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -1.42
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK8,MAPK9,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 51
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,GRK2,MAPK7,MARK4,SIK2,STK33,SYK,TEK,TTK 15
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2008 FDA HISAMITSU PHARM CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint dislocation 163.38 18.71 102 16604 44480 90567261
Seronegative arthritis 149.08 18.71 71 16635 18163 90593578
Prescribed underdose 134.30 18.71 111 16595 74908 90536833
Joint stiffness 118.34 18.71 105 16601 77937 90533804
Lupus vulgaris 100.69 18.71 76 16630 44983 90566758
Retinitis 99.80 18.71 71 16635 38387 90573354
Walking aid user 97.83 18.71 68 16638 35438 90576303
Wound infection 94.38 18.71 107 16599 106295 90505446
Hypercholesterolaemia 93.84 18.71 104 16602 100788 90510953
Osteoporosis 92.36 18.71 101 16605 96430 90515311
Laryngitis 90.60 18.71 75 16631 50678 90561063
Type 2 diabetes mellitus 89.05 18.71 145 16561 203099 90408642
Lupus-like syndrome 88.90 18.71 73 16633 48773 90562968
Sciatica 88.30 18.71 101 16605 101281 90510460
Visual impairment 86.39 18.71 114 16592 132251 90479490
Road traffic accident 83.41 18.71 101 16605 107525 90504216
Upper respiratory tract infection 82.94 18.71 110 16596 128208 90483533
Pulmonary fibrosis 73.89 18.71 95 16611 107408 90504333
Osteoarthritis 69.15 18.71 127 16579 195603 90416138
Food intolerance 64.45 18.71 25 16681 3877 90607864
Joint range of motion decreased 63.79 18.71 100 16606 135543 90476198
Anti-cyclic citrullinated peptide antibody 63.22 18.71 47 16659 27174 90584567
Broncholithiasis 63.22 18.71 14 16692 293 90611448
Psoriasis 62.76 18.71 104 16602 147650 90464091
Injection site inflammation 60.77 18.71 25 16681 4516 90607225
Lymph node calcification 59.88 18.71 14 16692 376 90611365
Red blood cell sedimentation rate increased 58.33 18.71 74 16632 82521 90529220
Prescribed overdose 57.46 18.71 80 16626 97545 90514196
Hepatic cirrhosis 56.72 18.71 64 16642 63189 90548552
Liver function test increased 53.66 18.71 72 16634 84783 90526958
Hip arthroplasty 53.37 18.71 68 16638 76140 90535601
Foot deformity 52.88 18.71 60 16646 59591 90552150
Adjustment disorder with depressed mood 51.87 18.71 58 16648 56695 90555046
Exostosis 51.50 18.71 56 16650 53078 90558663
Urticaria thermal 50.61 18.71 13 16693 520 90611221
Lower limb fracture 50.53 18.71 70 16636 84943 90526798
Disability 50.46 18.71 49 16657 40696 90571045
Urticaria 50.39 18.71 149 16557 312585 90299156
Bone erosion 49.86 18.71 55 16651 52966 90558775
Dislocation of vertebra 49.11 18.71 56 16650 55912 90555829
Spinal fusion surgery 47.24 18.71 29 16677 12254 90599487
Deep vein thrombosis postoperative 46.18 18.71 61 16645 70748 90540993
Spondylitis 45.85 18.71 30 16676 14148 90597593
Knee arthroplasty 45.75 18.71 66 16640 83116 90528625
Autoimmune disorder 45.32 18.71 63 16643 76681 90535060
Irritable bowel syndrome 43.56 18.71 109 16597 207339 90404402
Swollen joint count increased 42.87 18.71 75 16631 111131 90500610
Ear infection 42.28 18.71 58 16648 69717 90542024
Administration site erythema 39.43 18.71 12 16694 897 90610844
Grip strength decreased 39.06 18.71 65 16641 92511 90519230
Mobility decreased 38.97 18.71 118 16588 250616 90361125
Fibromyalgia 36.80 18.71 102 16604 206167 90405574
Bronchial wall thickening 36.43 18.71 14 16692 2117 90609624
Drug ineffective 35.31 18.71 134 16572 1384164 89227577
Wheezing 35.09 18.71 110 16596 237970 90373771
Oedema 34.70 18.71 98 16608 200197 90411544
C-reactive protein increased 33.65 18.71 91 16615 181298 90430443
Lichen nitidus 33.21 18.71 7 16699 115 90611626
Gait inability 32.90 18.71 79 16627 146377 90465364
Drug-induced liver injury 32.35 18.71 59 16647 90259 90521482
Hypoaesthesia 29.99 18.71 126 16580 314084 90297657
Asthma 29.56 18.71 105 16601 242055 90369686
Wound 28.53 18.71 121 16585 302859 90308882
Hypertension 28.27 18.71 162 16544 457370 90154371
Injury 27.99 18.71 90 16616 197259 90414482
Pruritus 27.95 18.71 183 16523 541342 90070399
Blood cholesterol increased 27.83 18.71 93 16613 207919 90403822
Rheumatic fever 27.57 18.71 76 16630 153045 90458696
Muscular weakness 27.30 18.71 92 16614 206574 90405167
Liver injury 26.22 18.71 80 16626 170487 90441254
Musculoskeletal stiffness 26.06 18.71 116 16590 296416 90315325
Neutropenia 25.92 18.71 5 16701 224899 90386842
Helicobacter infection 25.69 18.71 96 16610 226754 90384987
Nail bed tenderness 25.34 18.71 7 16699 371 90611370
Delirium 25.29 18.71 58 16648 104301 90507440
Urosepsis 25.29 18.71 25 16681 21207 90590534
Dyspepsia 25.11 18.71 87 16619 198073 90413668
Amnesia 24.87 18.71 59 16647 108446 90503295
Psoriatic arthropathy 24.51 18.71 95 16611 228240 90383501
Asthenia 24.35 18.71 38 16668 533713 90078028
Oedema peripheral 24.26 18.71 103 16603 257812 90353929
Loss of personal independence in daily activities 23.95 18.71 67 16639 136038 90475703
Product dose omission issue 23.82 18.71 12 16694 291675 90320066
Rheumatoid factor positive 23.18 18.71 77 16629 171573 90440168
Muscle injury 21.89 18.71 77 16629 176577 90435164
Tachycardia 21.53 18.71 71 16635 157602 90454139
Anaemia 21.51 18.71 20 16686 352782 90258959
Sinusitis 20.85 18.71 121 16585 342967 90268774
White blood cell count decreased 20.84 18.71 3 16703 167106 90444635
Pigmentation disorder 20.25 18.71 13 16693 5936 90605805
Impaired healing 20.10 18.71 91 16615 234108 90377633
Disease progression 19.10 18.71 3 16703 156612 90455129
Contusion 18.93 18.71 94 16612 251122 90360619
Nasopharyngitis 18.84 18.71 134 16572 406970 90204771

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Choroiditis 76.34 22.69 17 2174 1358 42617786
Endophthalmitis 65.35 22.69 19 2172 4414 42614730
Visual acuity reduced 49.27 22.69 22 2169 17528 42601616
Intraocular pressure increased 46.45 22.69 16 2175 6417 42612727
Completed suicide 44.59 22.69 38 2153 96427 42522717
Condition aggravated 43.83 22.69 60 2131 260694 42358450
Eye pain 40.42 22.69 19 2172 17011 42602133
Pruritus 32.49 22.69 44 2147 188727 42430417
Toxicity to various agents 31.52 22.69 48 2143 229088 42390056
Anticholinergic syndrome 28.77 22.69 8 2183 1581 42617563
Chondritis 26 22.69 5 2186 193 42618951
Dermatitis exfoliative 23.70 22.69 10 2181 6937 42612207

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 76.23 15.76 25 10829 4502 110573943
Injection site inflammation 74.94 15.76 25 10829 4746 110573699
Broncholithiasis 66.56 15.76 13 10841 279 110578166
Pruritus 63.53 15.76 161 10693 581399 109997046
Lymph node calcification 60.42 15.76 13 10841 456 110577989
Urticaria thermal 58.81 15.76 13 10841 518 110577927
Choroiditis 58.00 15.76 16 10838 1599 110576846
Administration site erythema 55.60 15.76 12 10842 427 110578018
Completed suicide 40.96 15.76 80 10774 242301 110336144
Endophthalmitis 38.78 15.76 18 10836 8169 110570276
Sciatica 37.83 15.76 46 10808 92353 110486092
Lichen nitidus 36.08 15.76 7 10847 145 110578300
Bronchial wall thickening 35.69 15.76 13 10841 3194 110575251
Psoriasis 33.72 15.76 54 10800 139939 110438506
Urosepsis 33.09 15.76 26 10828 30649 110547796
Scratch 30.96 15.76 18 10836 12961 110565484
Soft tissue necrosis 30.16 15.76 9 10845 1189 110577256
Nail bed tenderness 29.61 15.76 7 10847 377 110578068
Road traffic accident 29.47 15.76 44 10810 107354 110471091
Asthma 25.89 15.76 68 10786 250223 110328222
Intraocular pressure increased 25.72 15.76 15 10839 10861 110567584
Pulmonary fibrosis 25.45 15.76 40 10814 102002 110476443
Pigmentation disorder 25.38 15.76 13 10841 7298 110571147
Toxicity to various agents 24.76 15.76 103 10751 480452 110097993
Sleep disorder due to general medical condition, insomnia type 24.41 15.76 40 10814 105603 110472842
Visual acuity reduced 21.96 15.76 21 10833 32152 110546293
Neutropenia 21.84 15.76 5 10849 374615 110203830
Vitamin B12 deficiency 21.51 15.76 13 10841 10042 110568403
Anticipatory anxiety 21.40 15.76 7 10847 1249 110577196
Skin plaque 21.17 15.76 14 10840 12631 110565814
Eye pain 20.59 15.76 25 10829 50074 110528371
Drug intolerance 19.28 15.76 85 10769 406427 110172018
Seronegative arthritis 18.30 15.76 13 10841 13164 110565281
Condition aggravated 18.28 15.76 129 10725 734707 109843738
Secretion discharge 17.32 15.76 15 10839 20229 110558216
Autonomic neuropathy 17.27 15.76 7 10847 2293 110576152
Vulvovaginal swelling 17.16 15.76 5 10849 608 110577837
Dizziness postural 17.10 15.76 13 10841 14596 110563849
Prescribed underdose 16.88 15.76 26 10828 65148 110513297
Chondritis 16.26 15.76 4 10850 255 110578190
Adverse event 16.08 15.76 34 10820 108775 110469670
Anticholinergic syndrome 16.00 15.76 8 10846 4272 110574173
Post inflammatory pigmentation change 15.99 15.76 5 10849 772 110577673

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005404 Fixatives
MeSH PA D018501 Antirheumatic Agents
CHEBI has role CHEBI:24850 insect attractant
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35617 flavouring agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019432 VUID
N0000147562 NUI
D01087 KEGG_DRUG
4019432 VANDF
C0066282 UMLSCUI
CHEBI:88839 CHEBI
CHEMBL108545 ChEMBL_ID
DB09543 DRUGBANK_ID
C033069 MESH_SUPPLEMENTAL_RECORD_UI
2431 IUPHAR_LIGAND_ID
LAV5U5022Y UNII
4133 PUBCHEM_CID
29787 RXNORM
5086 MMSL
6316 MMSL
001588 NDDF
001990 NDDF
111141006 SNOMEDCT_US
386988003 SNOMEDCT_US
LAV5U5022Y INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Theragesic HUMAN OTC DRUG LABEL 2 0178-0320 CREAM 150 mg TOPICAL OTC Monograph Drug 16 sections
Theragesic Plus HUMAN OTC DRUG LABEL 2 0178-0350 GEL 250 mg TOPICAL OTC monograph not final 15 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 12 sections
WALGREENS COOL AND HEAT MUSCLE AND JOINT RELIEF HUMAN OTC DRUG LABEL 2 0363-0147 CREAM 30 g TOPICAL OTC monograph not final 11 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 36 mg TOPICAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 13 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0363-0855 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 13 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 10 g TOPICAL OTC Monograph Drug 11 sections
Walgreens Pain RelievingAnalgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 300 mg TOPICAL OTC Monograph Drug 15 sections
Walgreens Pain Relieving Patch HUMAN OTC DRUG LABEL 3 0363-6716 PATCH 100 mg TOPICAL OTC Monograph Drug 13 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 6.30 g TOPICAL OTC Monograph Drug 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 10 g TOPICAL OTC Monograph Drug 13 sections
Rugby Pain RelievingAnalgesic HUMAN OTC DRUG LABEL 2 0536-1101 CREAM 150 mg TOPICAL OTC Monograph Drug 15 sections
Rugby Muscle Rub Cream HUMAN OTC DRUG LABEL 2 0536-1349 CREAM 150 mg TOPICAL OTC Monograph Drug 9 sections
Rugby Pain RelievingAnalgesic HUMAN OTC DRUG LABEL 2 0536-1477 CREAM 150 mg TOPICAL OTC Monograph Drug 15 sections
Advil Targeted Relief HUMAN OTC DRUG LABEL 4 0573-6555 CREAM 150 mg TOPICAL OTC Monograph Drug 16 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 13 sections
foot worksarthritis achy foot and muscle HUMAN OTC DRUG LABEL 1 10096-0004 CREAM 250 mg TOPICAL OTC monograph not final 12 sections
AVON footworks Arthritis Achy Foot and Muscle HUMAN OTC DRUG LABEL 1 10096-4001 CREAM 250 mg TOPICAL OTC Monograph Drug 13 sections
Herb Street Sore Muscle Relief HUMAN OTC DRUG LABEL 1 10107-420 STICK 0.25 g TOPICAL OTC Monograph Drug 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 10202-664 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 12 sections
Mentholatum Deep Heating RubExtra Strength HUMAN OTC DRUG LABEL 2 10742-2002 CREAM 300 mg TOPICAL OTC Monograph Drug 11 sections
Calorub HUMAN OTC DRUG LABEL 2 10742-2120 CREAM 128 mg TOPICAL Export only 1 sections
Ultra Strength Muscle Rub HUMAN OTC DRUG LABEL 3 10742-6000 CREAM 300 mg TOPICAL OTC Monograph Drug 12 sections
Mentholatum Pain Relieving HUMAN OTC DRUG LABEL 2 10742-8169 LOTION 200 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Cool N HeatTherapy Pain Relief Stick HUMAN OTC DRUG LABEL 2 10889-201 STICK 30 1 TOPICAL OTC monograph final 11 sections
CVS Cold and HotPain Relieving Stick HUMAN OTC DRUG LABEL 2 10889-202 STICK 30 1 TOPICAL OTC monograph final 11 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 11344-072 MOUTHWASH 0.60 mg ORAL OTC Monograph Drug 14 sections