magnesium hydroxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4244	1309-42-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: magnesium hydroxide	An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects. Molecular weight: 58.32 Formula: H2MgO2 CLOGP: -1.75 LIPINSKI: None HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

magnesium hydroxide

An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.

Molecular weight: 58.32
Formula: H2MgO2
CLOGP: -1.75
LIPINSKI: None
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS:
ROTB: 0

Drug dosage:

Dose	Unit	Route
3	g	O
0.50	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 16, 2000	FDA	MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	736.83	11.12	309	49663	13513	63425537
Creatinine renal clearance decreased	690.86	11.12	310	49662	15998	63423052
Orthostatic hypotension	668.52	11.12	393	49579	35767	63403283
Cognitive disorder	642.56	11.12	450	49522	55365	63383685
Sedation	627.48	11.12	387	49585	38422	63400628
Blood calcium decreased	598.10	11.12	328	49644	26123	63412927
Balance disorder	503.85	11.12	463	49509	83959	63355091
Toxicity to various agents	445.99	11.12	740	49232	246510	63192540
Depressed level of consciousness	382.99	11.12	347	49625	61731	63377319
Hypotension	355.46	11.12	709	49263	271895	63167155
Mobility decreased	235.99	11.12	376	49596	120783	63318267
Infusion related reaction	203.19	11.12	534	49438	244987	63194063
Blood pressure fluctuation	196.23	11.12	211	49761	46106	63392944
Rheumatoid arthritis	191.92	11.12	534	49438	253285	63185765
Fall	163.80	11.12	676	49296	391658	63047392
Constipation	154.19	11.12	457	49515	224486	63214564
Blood pressure increased	145.80	11.12	364	49608	161698	63277352
Macular degeneration	126.69	11.12	124	49848	24252	63414798
Heart rate decreased	125.94	11.12	167	49805	45393	63393657
Drug abuse	124.81	11.12	213	49759	72305	63366745
Temperature regulation disorder	122.08	11.12	70	49902	6062	63432988
Electric shock	110.74	11.12	41	49931	1279	63437771
Immunodeficiency	108.95	11.12	105	49867	20149	63418901
Throat irritation	104.05	11.12	138	49834	37509	63401541
Pain	91.91	11.12	937	49035	739691	62699359
Blood pressure systolic increased	89.27	11.12	145	49827	47252	63391798
Food allergy	89.04	11.12	73	49899	11328	63427722
Maternal exposure during pregnancy	85.69	11.12	33	49939	220029	63219021
Oxygen saturation decreased	83.84	11.12	203	49769	88382	63350668
Systemic lupus erythematosus	81.89	11.12	31	49941	208887	63230163
Intervertebral discitis	78.38	11.12	42	49930	3186	63435864
Coeliac disease	75.82	11.12	70	49902	12727	63426323
Blood pressure systolic abnormal	75.03	11.12	71	49901	13315	63425735
Blood pressure diastolic abnormal	73.74	11.12	73	49899	14469	63424581
Heart rate increased	72.71	11.12	200	49772	94038	63345012
Glossodynia	69.33	11.12	27	49945	178849	63260201
Post-traumatic stress disorder	64.22	11.12	44	49928	5207	63433843
Blood pressure diastolic decreased	63.91	11.12	84	49888	22622	63416428
Smear cervix abnormal	59.63	11.12	34	49938	2912	63436138
Alopecia	58.92	11.12	110	49862	337426	63101624
Pericarditis	50.75	11.12	20	49952	131559	63307491
Pemphigus	49.56	11.12	43	49929	183683	63255367
Demyelination	49.25	11.12	42	49930	6878	63432172
Hand deformity	48.51	11.12	33	49939	159424	63279626
Product dose omission issue	45.78	11.12	71	49901	234242	63204808
Cataract	44.90	11.12	122	49850	56931	63382119
Hyperhidrosis	43.34	11.12	184	49788	107652	63331398
Rash erythematous	41.90	11.12	99	49873	42411	63396639
Temperature intolerance	39.99	11.12	42	49930	8922	63430128
Progressive multifocal leukoencephalopathy	39.66	11.12	50	49922	12921	63426129
Adrenal insufficiency	39.57	11.12	59	49913	17856	63421194
Anti-cyclic citrullinated peptide antibody positive	38.17	11.12	22	49950	116190	63322860
Ulcer	37.61	11.12	71	49901	26036	63413014
Weight increased	36.52	11.12	339	49633	260453	63178597
Wound	36.36	11.12	45	49927	163218	63275832
Respiratory rate increased	36.12	11.12	49	49923	13599	63425451
Tooth disorder	35.02	11.12	72	49900	28085	63410965
Herpes zoster	34.92	11.12	143	49829	82319	63356731
Muscle injury	34.80	11.12	5	49967	65340	63373710
General physical health deterioration	34.78	11.12	66	49906	201336	63237714
Multiple sclerosis	34.76	11.12	66	49906	24306	63414744
Condition aggravated	34.57	11.12	181	49791	402036	63037014
Exposure during pregnancy	34.50	11.12	43	49929	155504	63283546
Injection site pain	34.25	11.12	31	49941	129769	63309281
Arterial occlusive disease	34.15	11.12	32	49940	5926	63433124
Gastric disorder	33.59	11.12	84	49888	37285	63401765
Gangrene	33.41	11.12	32	49940	6091	63432959
Coordination abnormal	32.80	11.12	47	49925	13726	63425324
Multiple drug therapy	31.99	11.12	25	49947	3621	63435429
Diarrhoea	31.64	11.12	386	49586	714980	62724070
Injection site erythema	31.48	11.12	13	49959	83161	63355889
Sleep disorder due to general medical condition, insomnia type	30.26	11.12	3	49969	52214	63386836
Weight decreased	30.24	11.12	342	49630	276456	63162594
Folliculitis	30.02	11.12	9	49963	70308	63368742
Irritable bowel syndrome	29.43	11.12	14	49958	82398	63356652
Nail bed inflammation	28.62	11.12	11	49961	381	63438669
Bursitis	27.94	11.12	78	49894	36963	63402087
Skin fissures	27.32	11.12	39	49933	11349	63427701
Hypermagnesaemia	27.27	11.12	14	49958	972	63438078
Cystic fibrosis pancreatic	27.17	11.12	7	49965	61	63438989
Drug interaction	26.50	11.12	92	49880	229039	63210011
Acute kidney injury	25.84	11.12	113	49859	263302	63175748
Discomfort	25.40	11.12	59	49913	167315	63271735
Erythema	25.35	11.12	230	49742	175521	63263529
Duodenal ulcer perforation	25.26	11.12	19	49953	87190	63351860
Synovitis	25.19	11.12	70	49902	186848	63252202
Wheezing	25.01	11.12	23	49949	95572	63343478
Helicobacter infection	24.66	11.12	22	49950	92763	63346287
Anticholinergic syndrome	24.59	11.12	18	49954	2364	63436686
Fluid retention	24.09	11.12	102	49870	59584	63379466
Neuralgia	24.06	11.12	59	49913	25867	63413183
Joint injury	24.03	11.12	64	49908	29508	63409542
Endodontic procedure	23.92	11.12	20	49952	3187	63435863
Swelling	23.59	11.12	124	49848	275254	63163796
Abdominal discomfort	23.48	11.12	152	49820	320733	63118317
Rash	23.13	11.12	307	49665	560564	62878486
Flushing	22.73	11.12	118	49854	74969	63364081
Cardiac failure	22.67	11.12	22	49950	89120	63349930
Dry mouth	22.63	11.12	121	49851	77742	63361308
COVID-19	22.33	11.12	34	49938	113069	63325981
Arthritis	22.29	11.12	162	49810	115759	63323291
Localised infection	22.18	11.12	63	49909	30147	63408903
Product use issue	21.99	11.12	94	49878	220426	63218624
Excessive skin	21.88	11.12	7	49965	139	63438911
Body temperature decreased	21.87	11.12	49	49923	20270	63418780
Off label use	21.43	11.12	388	49584	674074	62764976
Adverse drug reaction	21.06	11.12	19	49953	79695	63359355
Injection site extravasation	20.80	11.12	30	49942	8811	63430239
Ear pruritus	20.28	11.12	20	49952	3945	63435105
Arthralgia	20.24	11.12	589	49383	569121	62869929
Rheumatoid factor positive	20.14	11.12	22	49950	84384	63354666
Confusional state	19.92	11.12	107	49865	236273	63202777
Contraindicated product administered	19.77	11.12	96	49876	217552	63221498
Dyspnoea	19.60	11.12	385	49587	660928	62778122
Loss of personal independence in daily activities	19.44	11.12	29	49943	97261	63341789
Pregnancy	19.20	11.12	3	49969	36833	63402217
Paraesthesia	18.84	11.12	62	49910	156904	63282146
Occult blood	18.56	11.12	12	49960	1289	63437761
Ocular procedural complication	18.33	11.12	8	49964	385	63438665
Lower respiratory tract infection	18.23	11.12	49	49923	132258	63306792
Cough	17.98	11.12	327	49645	292416	63146634
Nasopharyngitis	17.78	11.12	290	49682	253967	63185083
Fumbling	17.69	11.12	6	49966	144	63438906
Wrong technique in product usage process	17.52	11.12	14	49958	62326	63376724
Vomiting	17.42	11.12	323	49649	559294	62879756
Treatment failure	17.38	11.12	89	49883	198954	63240096
Toothache	17.09	11.12	43	49929	19156	63419894
Nose deformity	16.92	11.12	6	49966	165	63438885
Therapeutic response decreased	16.79	11.12	94	49878	61431	63377619
Tongue disorder	16.78	11.12	30	49942	10550	63428500
Heliotrope rash	16.39	11.12	6	49966	181	63438869
Inappropriate schedule of product administration	16.29	11.12	36	49936	103929	63335121
Endometrial disorder	16.23	11.12	9	49963	730	63438320
Laryngitis	16.16	11.12	39	49933	16928	63422122
Therapy interrupted	16.13	11.12	3	49969	32452	63406598
Allergy to plants	16.04	11.12	9	49963	747	63438303
Vein collapse	15.81	11.12	10	49962	1034	63438016
Foetal exposure during pregnancy	15.78	11.12	3	49969	31959	63407091
Overdose	15.78	11.12	149	49823	114929	63324121
Psoriatic arthropathy	15.77	11.12	30	49942	91490	63347560
Drug-induced liver injury	15.69	11.12	6	49966	40216	63398834
Treatment noncompliance	15.53	11.12	5	49967	37320	63401730
Periorbital swelling	15.45	11.12	15	49957	2903	63436147
Abortion spontaneous	15.40	11.12	9	49963	47186	63391864
Intensive care unit acquired weakness	15.35	11.12	9	49963	812	63438238
Poikiloderma	15.21	11.12	6	49966	223	63438827
Dysphagia	14.90	11.12	120	49852	88465	63350585
No adverse event	14.83	11.12	7	49965	41398	63397652
Back pain	14.82	11.12	291	49681	263854	63175196
Swollen joint count increased	14.70	11.12	5	49967	36049	63403001
Renal impairment	14.34	11.12	30	49942	88325	63350725
Injection site pruritus	14.16	11.12	9	49963	45107	63393943
Cholestasis	14.04	11.12	3	49969	29431	63409619
Myelopathy	13.98	11.12	14	49958	2812	63436238
Vaginal flatulence	13.93	11.12	15	49957	3278	63435772
Mechanical urticaria	13.87	11.12	7	49965	469	63438581
Psoriasis	13.71	11.12	30	49942	86927	63352123
Viral upper respiratory tract infection	13.69	11.12	23	49949	7701	63431349
Death	13.61	11.12	210	49762	374171	63064879
Iron deficiency	13.44	11.12	22	49950	7208	63431842
Nerve compression	13.44	11.12	25	49947	9062	63429988
Liver injury	13.13	11.12	17	49955	60503	63378547
Injection site swelling	12.98	11.12	11	49961	47561	63391489
White blood cells urine positive	12.87	11.12	18	49954	5140	63433910
Oropharyngeal pain	12.78	11.12	122	49850	94365	63344685
Chronic sinusitis	12.75	11.12	30	49942	12813	63426237
Gastrointestinal disorder	12.43	11.12	57	49915	131182	63307868
Enterococcus test positive	12.42	11.12	9	49963	1164	63437886
Thrombocytopenia	12.41	11.12	69	49903	151088	63287962
Paraesthesia oral	12.09	11.12	38	49934	19218	63419832
Vein rupture	11.95	11.12	9	49963	1234	63437816
Lip blister	11.91	11.12	12	49960	2428	63436622
Benign vaginal neoplasm	11.87	11.12	4	49968	94	63438956
Cystitis	11.83	11.12	79	49893	54912	63384138
Malignant neoplasm progression	11.62	11.12	30	49942	82091	63356959
Dental caries	11.61	11.12	26	49946	10753	63428297
Hyponatraemia	11.57	11.12	47	49925	111853	63327197
Product use in unapproved indication	11.53	11.12	88	49884	178992	63260058
Noninfective encephalitis	11.41	11.12	6	49966	438	63438612
Sleep disorder	11.39	11.12	30	49942	81536	63357514
Dust allergy	11.31	11.12	7	49965	697	63438353
C-reactive protein increased	11.22	11.12	119	49853	94588	63344462
Injection site reaction	11.16	11.12	18	49954	58506	63380544
Spinal osteoarthritis	11.15	11.12	33	49939	16153	63422897
Therapy cessation	11.14	11.12	5	49967	30452	63408598

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	203.27	13.10	358	16906	200004	34739663
Drug abuse	133.99	13.10	202	17062	98894	34840773
Infusion related reaction	107.96	13.10	132	17132	52925	34886742
Oxygen saturation decreased	70.19	13.10	108	17156	53710	34885957
Blood pressure increased	69.75	13.10	142	17122	87960	34851707
Blood pressure fluctuation	56.53	13.10	66	17198	25183	34914484
Heart rate decreased	55.06	13.10	73	17191	31672	34907995
Rheumatoid arthritis	43.33	13.10	72	17192	38166	34901501
Nasopharyngitis	32.74	13.10	92	17172	69876	34869791
Blood pressure diastolic decreased	27.75	13.10	28	17236	9066	34930601
Device breakage	24.85	13.10	15	17249	2285	34937382
Blood pressure systolic increased	24.37	13.10	42	17222	22910	34916757
Clumsiness	23.24	13.10	13	17251	1719	34937948
Constipation	22.68	13.10	130	17134	136852	34802815
Normochromic normocytic anaemia	22.65	13.10	18	17246	4269	34935398
Hypermagnesaemia	21.28	13.10	7	17257	247	34939420
Arthralgia	21.12	13.10	150	17114	169891	34769776
Blood pressure diastolic abnormal	20.81	13.10	18	17246	4800	34934867
Hernia	19.71	13.10	24	17240	9559	34930108
Perineal pain	19.18	13.10	9	17255	824	34938843
Pemphigus	18.57	13.10	11	17253	1620	34938047
Supraventricular tachycardia	18.40	13.10	25	17239	11092	34928575
Unresponsive to stimuli	17.83	13.10	41	17223	27528	34912139
Haematocrit decreased	16.69	13.10	44	17220	32172	34907495
Environmental exposure	16.52	13.10	6	17258	286	34939381
Phlebosclerosis	16.07	13.10	5	17259	147	34939520
Granulomatosis with polyangiitis	16.04	13.10	9	17255	1196	34938471
Red cell distribution width increased	15.38	13.10	17	17247	6106	34933561
Drug interaction	15.07	13.10	59	17205	225887	34713780
Blood pressure diastolic increased	14.47	13.10	15	17249	5010	34934657
Antineutrophil cytoplasmic antibody positive	13.65	13.10	7	17257	777	34938890
Therapeutic product effect incomplete	13.65	13.10	4	17260	50537	34889130
Dysphagia	13.63	13.10	64	17200	62317	34877350
Heart rate increased	13.59	13.10	52	17212	46291	34893376
Musculoskeletal disorder	13.52	13.10	16	17248	6188	34933479

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	759.00	11.22	321	58388	15348	79670331
Creatinine renal clearance decreased	699.53	11.22	321	58388	18681	79666998
Cognitive disorder	611.33	11.22	465	58244	69461	79616218
Blood calcium decreased	588.47	11.22	338	58371	31481	79654198
Toxicity to various agents	580.98	11.22	1079	57630	420461	79265218
Sedation	566.97	11.22	395	58314	51500	79634179
Orthostatic hypotension	550.22	11.22	400	58309	55764	79629915
Balance disorder	475.21	11.22	467	58242	98390	79587289
Infusion related reaction	371.06	11.22	632	58077	229605	79456074
Depressed level of consciousness	320.21	11.22	375	58334	96277	79589402
Rheumatoid arthritis	319.74	11.22	560	58149	207910	79477769
Hypotension	275.75	11.22	829	57880	439488	79246191
Mobility decreased	264.03	11.22	384	58325	121791	79563888
Blood pressure fluctuation	234.86	11.22	268	58441	66877	79618802
Blood pressure increased	217.21	11.22	480	58229	210880	79474799
Drug abuse	212.55	11.22	408	58301	162283	79523396
Pain	178.31	11.22	1001	57708	702801	78982878
Heart rate decreased	174.09	11.22	236	58473	70080	79615599
Constipation	156.53	11.22	511	58198	282539	79403140
Fall	140.49	11.22	719	57990	486910	79198769
Oxygen saturation decreased	136.87	11.22	297	58412	128750	79556929
Temperature regulation disorder	126.71	11.22	69	58640	5784	79679895
Throat irritation	109.88	11.22	143	58566	40803	79644876
Electric shock	103.91	11.22	39	58670	1355	79684324
Blood pressure systolic increased	103.81	11.22	181	58528	66805	79618874
Immunodeficiency	102.87	11.22	102	58607	21666	79664013
Food allergy	94.49	11.22	72	58637	10752	79674927
Blood pressure diastolic abnormal	90.78	11.22	90	58619	19112	79666567
Blood pressure diastolic decreased	88.13	11.22	110	58599	30106	79655573
Blood pressure systolic abnormal	85.57	11.22	83	58626	17164	79668515
Coeliac disease	85.05	11.22	69	58640	11282	79674397
Heart rate increased	78.69	11.22	231	58478	120493	79565186
Smear cervix abnormal	66.54	11.22	34	58675	2502	79683177
Intervertebral discitis	65.29	11.22	42	58667	4786	79680893
Post-traumatic stress disorder	64.87	11.22	42	58667	4839	79680840
Acute kidney injury	64.13	11.22	184	58525	519220	79166459
Drug interaction	62.25	11.22	133	58576	415050	79270629
Cataract	60.22	11.22	138	58571	61982	79623697
Condition aggravated	55.84	11.22	186	58523	500938	79184741
Arthralgia	52.05	11.22	646	58063	571157	79114522
Nasopharyngitis	49.94	11.22	339	58370	253542	79432137
Tooth disorder	48.83	11.22	77	58632	26156	79659523
Weight increased	45.70	11.22	355	58354	277031	79408648
Demyelination	44.35	11.22	41	58668	7982	79677697
Respiratory rate increased	43.85	11.22	66	58643	21534	79664145
Diarrhoea	41.73	11.22	431	58278	880058	78805621
Product dose omission issue	41.65	11.22	74	58635	247463	79438216
Hyperhidrosis	41.08	11.22	220	58489	151272	79534407
Multiple sclerosis	40.92	11.22	65	58644	22217	79663462
General physical health deterioration	40.52	11.22	89	58620	275149	79410530
Hypermagnesaemia	39.53	11.22	19	58690	1225	79684454
Temperature intolerance	37.79	11.22	41	58668	9664	79676015
Herpes zoster	37.68	11.22	152	58557	92931	79592748
Rash erythematous	36.15	11.22	109	58600	57660	79628019
Maternal exposure during pregnancy	35.52	11.22	29	58680	136509	79549170
Cardiac failure	35.41	11.22	37	58672	154805	79530874
Drug reaction with eosinophilia and systemic symptoms	33.43	11.22	4	58705	64240	79621439
Coordination abnormal	32.48	11.22	51	58658	17261	79668418
Gastric disorder	31.78	11.22	79	58630	37354	79648325
Weight decreased	31.25	11.22	399	58310	354799	79330880
Multiple drug therapy	30.99	11.22	25	58684	4053	79681626
Injection site erythema	30.09	11.22	10	58699	78187	79607492
Gangrene	30.00	11.22	35	58674	8929	79676750
Arterial occlusive disease	29.95	11.22	34	58675	8422	79677257
Bursitis	29.75	11.22	75	58634	35769	79649910
Localised infection	29.51	11.22	77	58632	37498	79648181
Systemic lupus erythematosus	28.78	11.22	28	58681	121121	79564558
Pericarditis	28.55	11.22	21	58688	104215	79581464
Body temperature decreased	28.52	11.22	69	58640	32076	79653603
Skin fissures	28.05	11.22	41	58668	13032	79672647
Neuralgia	27.86	11.22	70	58639	33314	79652365
Cystic fibrosis pancreatic	27.63	11.22	7	58702	61	79685618
Injection site pain	27.53	11.22	33	58676	129805	79555874
Ulcer	27.31	11.22	65	58644	29907	79655772
Glossodynia	26.81	11.22	22	58687	103315	79582364
Flushing	26.57	11.22	132	58577	88136	79597543
Off label use	25.78	11.22	492	58217	906723	78778956
Back pain	25.61	11.22	339	58370	303841	79381838
Adrenal insufficiency	24.05	11.22	60	58649	28427	79657252
COVID-19	24.01	11.22	50	58659	157624	79528055
Progressive multifocal leukoencephalopathy	23.64	11.22	49	58660	20551	79665128
Endodontic procedure	23.40	11.22	18	58691	2725	79682954
Dysphagia	23.33	11.22	162	58547	121974	79563705
Cholestasis	23.19	11.22	5	58704	52104	79633575
Therapeutic response decreased	23.05	11.22	104	58605	66749	79618930
Excessive skin	23.04	11.22	7	58702	125	79685554
Drug-induced liver injury	22.86	11.22	10	58699	66107	79619572
Nail bed inflammation	22.47	11.22	10	58699	540	79685139
Joint swelling	22.38	11.22	317	58392	288329	79397350
Irritable bowel syndrome	22.19	11.22	9	58700	62232	79623447
Injection site extravasation	21.73	11.22	31	58678	9638	79676041
Anticholinergic syndrome	21.03	11.22	19	58690	3592	79682087
Eosinophilia	20.90	11.22	4	58705	45341	79640338
Blood pressure diastolic increased	20.85	11.22	38	58671	14504	79671175
Loss of personal independence in daily activities	20.77	11.22	27	58682	102553	79583126
Fluid retention	20.72	11.22	104	58605	69705	79615974
Dry mouth	20.66	11.22	123	58586	87896	79597783
Laryngitis	20.62	11.22	40	58669	15999	79669680
Erythema	20.11	11.22	252	58457	223038	79462641
Renal impairment	20.07	11.22	55	58654	157728	79527951
Myocardial infarction	20.00	11.22	69	58640	184060	79501619
Anti-cyclic citrullinated peptide antibody positive	20.00	11.22	19	58690	83124	79602555
Upper respiratory tract infection	19.88	11.22	125	58584	91043	79594636
Folliculitis	19.75	11.22	8	58701	55372	79630307
Allergy to plants	19.41	11.22	10	58699	749	79684930
Hand deformity	19.39	11.22	29	58680	103890	79581789
Inappropriate schedule of product administration	19	11.22	44	58665	133584	79552095
Vein rupture	18.78	11.22	14	58695	2022	79683657
Fumbling	18.36	11.22	6	58703	137	79685542
Endometrial disorder	18.33	11.22	9	58700	608	79685071
Alopecia	18.20	11.22	98	58611	231257	79454422
Vaginal flatulence	17.92	11.22	15	58694	2560	79683119
Thrombocytopenia	17.89	11.22	118	58591	265141	79420538
Toothache	17.86	11.22	43	58666	19927	79665752
Confusional state	17.85	11.22	149	58560	317848	79367831
Wheezing	17.75	11.22	37	58672	116627	79569052
Ocular procedural complication	17.30	11.22	8	58701	473	79685206
Rhabdomyolysis	17.18	11.22	31	58678	103100	79582579
Nose deformity	17.14	11.22	6	58703	170	79685509
Ear pruritus	17.11	11.22	18	58691	4097	79681582
Granulomatosis with polyangiitis	16.51	11.22	15	58694	2855	79682824
Periorbital swelling	16.40	11.22	15	58694	2881	79682798
Tubulointerstitial nephritis	16.35	11.22	4	58705	38231	79647448
Heliotrope rash	16.33	11.22	6	58703	196	79685483
Occult blood	16.23	11.22	12	58697	1711	79683968
Perineal pain	16.10	11.22	10	58699	1072	79684607
Body temperature increased	15.99	11.22	70	58639	44350	79641329
Psoriasis	15.77	11.22	26	58683	89561	79596118
Tongue disorder	15.75	11.22	33	58676	13942	79671737
Vein collapse	15.72	11.22	10	58699	1118	79684561
Environmental exposure	15.44	11.22	7	58702	395	79685284
Poikiloderma	15.42	11.22	7	58702	396	79685283
Paraesthesia	15.40	11.22	72	58637	176251	79509428
Hepatocellular injury	15.23	11.22	8	58701	47585	79638094
Arthritis	15.16	11.22	140	58569	114740	79570939
Duodenal ulcer perforation	14.93	11.22	16	58693	66195	79619484
Mechanical urticaria	14.85	11.22	7	58702	432	79685247
Hypoglycaemia	14.81	11.22	33	58676	101561	79584118
Dyspnoea	14.56	11.22	501	58208	856524	78829155
Multiple organ dysfunction syndrome	14.49	11.22	43	58666	120203	79565476
Hyperkalaemia	14.46	11.22	40	58669	114358	79571321
Epilepsy	14.41	11.22	6	58703	40854	79644825
Swelling face	14.15	11.22	19	58690	71193	79614486
Phlebosclerosis	14.08	11.22	5	58704	148	79685531
Therapy interrupted	13.96	11.22	3	58706	31338	79654341
Cystitis	13.89	11.22	76	58633	52656	79633023
No adverse event	13.88	11.22	5	58704	37187	79648492
Radiculopathy	13.86	11.22	24	58685	8800	79676879
Exposure during pregnancy	13.82	11.22	34	58675	101098	79584581
Oropharyngeal pain	13.80	11.22	132	58577	109221	79576458
Diabetic ketoacidosis	13.78	11.22	4	58705	34118	79651561
Hot flush	13.73	11.22	78	58631	54799	79630880
Treatment noncompliance	13.71	11.22	11	58698	52257	79633422
Haematemesis	13.71	11.22	11	58698	52253	79633426
Synovitis	13.49	11.22	61	58648	150673	79535006
Helicobacter infection	13.45	11.22	19	58690	69685	79615994
Dental caries	13.43	11.22	28	58681	11792	79673887
Joint effusion	13.22	11.22	36	58673	17978	79667701
Drug ineffective for unapproved indication	13.17	11.22	11	58698	51227	79634452
Gastrointestinal disorder	13.13	11.22	46	58663	122159	79563520
Macular degeneration	13.12	11.22	27	58682	11269	79674410
Osteonecrosis of jaw	12.78	11.22	8	58701	43218	79642461
Obesity	12.65	11.22	5	58704	35120	79650559
Benign vaginal neoplasm	12.56	11.22	4	58705	84	79685595
Circulatory collapse	12.55	11.22	6	58703	37662	79648017
Cough	12.49	11.22	356	58353	366433	79319246
Treatment failure	12.44	11.22	74	58635	170412	79515267
Ill-defined disorder	12.35	11.22	87	58622	65788	79619891
Injection site pruritus	12.26	11.22	8	58701	42275	79643404
Viral upper respiratory tract infection	12.21	11.22	23	58686	9003	79676676
Accidental exposure to product	12.06	11.22	4	58705	31318	79654361
Intervertebral disc degeneration	12.04	11.22	32	58677	15753	79669926
Blood lactate dehydrogenase increased	11.93	11.22	7	58702	39163	79646516
Clumsiness	11.81	11.22	13	58696	3114	79682565
Female genital tract fistula	11.76	11.22	18	58691	5957	79679722
Loss of consciousness	11.68	11.22	74	58635	167869	79517810
Neuroleptic malignant syndrome	11.56	11.22	3	58706	27556	79658123
Hyponatraemia	11.54	11.22	80	58629	177768	79507911
Disease progression	11.45	11.22	84	58625	184278	79501401
Lip blister	11.32	11.22	12	58697	2755	79682924
Paraesthesia oral	11.31	11.22	37	58672	20434	79665245

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02AA04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS ANTACIDS Magnesium compounds
ATC	G04BX01	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals
MeSH PA	D000863	Antacids
MeSH PA	D005765	Gastrointestinal Agents
CHEBI has role	CHEBI:65265	antacids
CHEBI has role	CHEBI:79314	flame retardants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Constipation	indication	14760008	DOID:2089
Heartburn	indication	16331000
Indigestion	indication	162031009
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Incomplete passage of stool	indication	249515001
Gastric Hypersecretory Conditions	indication
Heartburn Prevention	indication
Hiatal Hernia with Reflux Esophagitis	indication
Hypocalcemia	off-label use	5291005
Upper gastrointestinal hemorrhage	off-label use	37372002
Duodenal ulcer disease	off-label use	51868009	DOID:1724
Zollinger-Ellison syndrome	off-label use	53132006	DOID:0050782
Multiple endocrine adenomas	off-label use	60549007
Osteoporosis	off-label use	64859006	DOID:11476
Postmenopausal osteoporosis	off-label use	102447009
Systemic mast cell disease	off-label use	397016004	DOID:349
Gastric ulcer	off-label use	397825006	DOID:10808
Stress-Related GI Mucosal Bleeding Prevention	off-label use
Prevention of Stress Ulcer	off-label use
Maintenance of Healing Duodenal Ulcer	off-label use
Renal Osteodystrophy with Hyperphosphatemia	off-label use
Dyspepsia Prevention	off-label use
Hypophosphatemia	contraindication	4996001
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Fecal impaction	contraindication	44635007
Diarrhea	contraindication	62315008
Hypercalcemia	contraindication	66931009	DOID:12678
Hypermagnesemia	contraindication	66978005
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hemorrhoids	contraindication	70153002	DOID:9746
Appendicitis	contraindication	74400008	DOID:8337
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Gastrointestinal obstruction	contraindication	126765001
Impaired renal function disorder	contraindication	197663003
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Chronic diarrhea	contraindication	236071009
Aluminum intoxication	contraindication	236546003
Malignant tumor of stomach	contraindication	363349007	DOID:10534

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017693	VUID
N0000146067	NUI
D00731	KEGG_DRUG
4017693	VANDF
C0024476	UMLSCUI
CHEBI:6637	CHEBI
CHEMBL1200718	ChEMBL_ID
D008276	MESH_DESCRIPTOR_UI
DB09104	DRUGBANK_ID
NBZ3QY004S	UNII
73981	PUBCHEM_CID
6581	RXNORM
5013	MMSL
5579	MMSL
d00982	MMSL
001119	NDDF
001186	NDDF
387337001	SNOMEDCT_US
60468008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Milk of Magnesia	HUMAN OTC DRUG LABEL	1	0054-3567	CONCENTRATE	2400 mg	ORAL	OTC monograph not final	10 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
good sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
good sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
good sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
good sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense antacid	HUMAN OTC DRUG LABEL	3	0113-0340	SUSPENSION	800 mg	ORAL	OTC monograph final	13 sections
Good Sense antacid	HUMAN OTC DRUG LABEL	3	0113-0340	SUSPENSION	800 mg	ORAL	OTC monograph final	13 sections
Good Sense AntacidRegular Strength	HUMAN OTC DRUG LABEL	3	0113-0357	SUSPENSION	400 mg	ORAL	OTC monograph final	13 sections
Good Sense AntacidRegular Strength	HUMAN OTC DRUG LABEL	3	0113-0357	SUSPENSION	400 mg	ORAL	OTC monograph final	13 sections
Good Sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0396	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0396	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0396	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense milk of magnesiastimulant free	HUMAN OTC DRUG LABEL	1	0113-0396	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense AntacidMaximum Strength	HUMAN OTC DRUG LABEL	3	0113-0588	SUSPENSION	800 mg	ORAL	OTC monograph final	13 sections
Good Sense AntacidMaximum Strength	HUMAN OTC DRUG LABEL	3	0113-0588	SUSPENSION	800 mg	ORAL	OTC monograph final	13 sections
good sense antacid	HUMAN OTC DRUG LABEL	3	0113-0851	SUSPENSION	400 mg	ORAL	OTC monograph final	13 sections
good sense antacid	HUMAN OTC DRUG LABEL	3	0113-0851	SUSPENSION	400 mg	ORAL	OTC monograph final	13 sections
Good Sense Milk of Magnesia	HUMAN OTC DRUG LABEL	1	0113-0949	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Good Sense Milk of Magnesia	HUMAN OTC DRUG LABEL	1	0113-0949	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
injoy heartburn relief	HUMAN OTC DRUG LABEL	3	0113-6023	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
injoy heartburn relief	HUMAN OTC DRUG LABEL	3	0113-6023	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
basic care dual action complete	HUMAN OTC DRUG LABEL	3	0113-7321	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
basic care dual action complete	HUMAN OTC DRUG LABEL	3	0113-7321	TABLET, CHEWABLE	165 mg	ORAL	ANDA	15 sections
basic care milk of magnesia	HUMAN OTC DRUG LABEL	1	0113-7332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
basic care milk of magnesia	HUMAN OTC DRUG LABEL	1	0113-7332	SUSPENSION	1200 mg	ORAL	OTC monograph not final	14 sections
Milk of Magnesia	HUMAN OTC DRUG LABEL	1	0121-0431	SUSPENSION	400 mg	ORAL	OTC monograph final	15 sections