avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4242	70356-09-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: avobenzone butylmethoxydibenzoylmethane photoplex	causes allergic or photoallergic contact dermatitis; structure given in first source Molecular weight: 310.39 Formula: C20H22O3 CLOGP: 4.68 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 43.37 ALOGS: -5.70 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

avobenzone
butylmethoxydibenzoylmethane
photoplex

causes allergic or photoallergic contact dermatitis; structure given in first source

Molecular weight: 310.39
Formula: C20H22O3
CLOGP: 4.68
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 43.37
ALOGS: -5.70
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	708.72	15.82	225	9275	24151	63455371
Chronic sinusitis	216.82	15.82	79	9421	12764	63466758
Paraesthesia oral	189.10	15.82	80	9420	19176	63460346
Therapy interrupted	178.00	15.82	90	9410	32365	63447157
Procedural pain	177.15	15.82	79	9421	21490	63458032
Body tinea	110.33	15.82	30	9470	1855	63477667
Vaginal flatulence	106.29	15.82	33	9467	3260	63476262
Therapy cessation	101.97	15.82	61	9439	30396	63449126
Inhibitory drug interaction	98.09	15.82	30	9470	2819	63476703
Proctitis	93.76	15.82	34	9466	5407	63474115
Radiculopathy	91.96	15.82	38	9462	8573	63470949
Infection susceptibility increased	91.83	15.82	30	9470	3491	63476031
Female genital tract fistula	89.77	15.82	36	9464	7523	63471999
Drug ineffective	89.61	15.82	349	9151	1044416	62435106
Therapeutic product effect incomplete	84.98	15.82	99	9401	124957	63354565
Glucose tolerance impaired	73.54	15.82	30	9470	6547	63472975
Vaginal discharge	73.27	15.82	33	9467	9165	63470357
Poor quality sleep	72.14	15.82	42	9458	19893	63459629
Dyspepsia	71.24	15.82	82	9418	102114	63377408
Death	69.89	15.82	165	9335	374216	63105306
Purpura	63.61	15.82	32	9468	11353	63468169
Impaired quality of life	57.85	15.82	32	9468	13751	63465771
Colitis ulcerative	57.05	15.82	40	9460	26051	63453471
Bone density decreased	53.43	15.82	31	9469	14581	63464941
Hyperlipidaemia	49.90	15.82	33	9467	19538	63459984
Impaired work ability	48.31	15.82	31	9469	17444	63462078
Surgery	47.76	15.82	41	9459	35871	63443651
Oral candidiasis	47.64	15.82	34	9466	22764	63456758
Frequent bowel movements	47.34	15.82	34	9466	22988	63456534
Skin disorder	44.01	15.82	36	9464	29471	63450051
Hospitalisation	42.79	15.82	58	9442	85023	63394499
Local anaesthetic systemic toxicity	42.03	15.82	12	9488	887	63478635
Removal of foreign body	41.18	15.82	7	9493	41	63479481
Oral herpes	39.28	15.82	32	9468	26042	63453480
Pyrexia	38.92	15.82	156	9344	470322	63009200
Tracheal deviation	38.42	15.82	8	9492	154	63479368
Rectal haemorrhage	36.95	15.82	41	9459	48989	63430533
Phrenic nerve paralysis	36.90	15.82	8	9492	188	63479334
Colitis	33.87	15.82	39	9461	48489	63431033
Weight decreased	33.38	15.82	104	9396	276694	63202828
Haematochezia	29.21	15.82	38	9462	53506	63426016
Herpes zoster	28.26	15.82	47	9453	82415	63397107
Cellulitis	27.14	15.82	46	9454	81912	63397610
Alopecia	24.40	15.82	10	9490	337526	63141996
Intentional dose omission	24.00	15.82	15	9485	8060	63471462
Foreign body in respiratory tract	23.07	15.82	6	9494	312	63479210
Drug intolerance	22.54	15.82	9	9491	308652	63170870
Infusion related reaction	21.50	15.82	83	9417	245438	63234084
Hepatic enzyme increased	20.38	15.82	3	9497	202325	63277197
Anaphylactic shock	19.96	15.82	21	9479	23612	63455910
Systemic lupus erythematosus	19.08	15.82	4	9496	208914	63270608
Cataract	18.85	15.82	32	9468	57021	63422501
Constipation	18.84	15.82	75	9425	224868	63254654
Purtscher retinopathy	18.45	15.82	4	9496	94	63479428
Rheumatoid arthritis	17.57	15.82	8	9492	253811	63225711
Jarisch-Herxheimer reaction	17.48	15.82	5	9495	372	63479150
Therapeutic product effect decreased	17.03	15.82	4	9496	193183	63286339
Chemical burn	16.89	15.82	5	9495	420	63479102
Foetal exposure during delivery	16.40	15.82	4	9496	160	63479362
Joint swelling	16.33	15.82	15	9485	327651	63151871

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	114.75	18.04	212	5163	397837	34553719
Therapy interrupted	107.51	18.04	49	5326	13648	34937908
Anal inflammation	72.35	18.04	20	5355	1280	34950276
Therapy cessation	69.20	18.04	39	5336	16934	34934622
SARS-CoV-2 test negative	62.84	18.04	17	5358	1003	34950553
Proctalgia	49.74	18.04	22	5353	5701	34945855
Accident	49.07	18.04	21	5354	5026	34946530
Surgery	43.22	18.04	27	5348	14130	34937426
Appendicolith	41.22	18.04	22	5353	8579	34942977
Ventricular fibrillation	39.96	18.04	31	5344	22923	34928633
Cardiogenic shock	35.93	18.04	31	5344	26587	34924969
Appendicitis	34.85	18.04	24	5351	14783	34936773
Removal of foreign body	34.74	18.04	6	5369	38	34951518
Haemorrhoids	30.53	18.04	22	5353	14553	34937003
Cardiac arrest	28.31	18.04	52	5323	96107	34855449
Body temperature increased	25.01	18.04	21	5354	17347	34934209
Stress	21.67	18.04	25	5350	30322	34921234
Ascites	21.64	18.04	31	5344	46540	34905016
Hospitalisation	20.96	18.04	34	5341	56868	34894688
Methaemoglobinaemia	19.55	18.04	10	5365	3571	34947985
Administration related reaction	18.14	18.04	4	5371	99	34951457

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	304.64	14.37	134	13363	31207	79699684
Death	214.77	14.37	360	13137	566154	79164737
Macular degeneration	202.32	14.37	75	13422	11221	79719670
Chronic sinusitis	195.46	14.37	76	13421	12950	79717941
Paraesthesia oral	174.83	14.37	80	13417	20391	79710500
Therapy cessation	174.00	14.37	97	13400	37465	79693426
Procedural pain	159.64	14.37	78	13419	23006	79707885
Body tinea	107.15	14.37	30	13467	1824	79729067
Vaginal flatulence	105.95	14.37	32	13465	2543	79728348
Surgery	103.14	14.37	66	13431	32700	79698191
Female genital tract fistula	90.10	14.37	35	13462	5940	79724951
Infection susceptibility increased	86.57	14.37	30	13467	3691	79727200
Inhibitory drug interaction	85.01	14.37	31	13466	4422	79726469
Proctitis	80.71	14.37	33	13464	6399	79724492
Radiculopathy	80.10	14.37	36	13461	8788	79722103
Hospitalisation	76.73	14.37	87	13410	94149	79636742
Therapeutic product effect incomplete	72.82	14.37	104	13393	141541	79589350
Vaginal discharge	72.73	14.37	32	13465	7431	79723460
Anal inflammation	64.15	14.37	19	13478	1411	79729480
Glucose tolerance impaired	64.03	14.37	30	13467	8054	79722837
Removal of foreign body	62.45	14.37	11	13486	71	79730820
Poor quality sleep	59.93	14.37	41	13456	22681	79708210
Dyspepsia	57.61	14.37	81	13416	108606	79622285
Impaired quality of life	52.89	14.37	32	13465	14354	79716537
Bone density decreased	52.48	14.37	31	13466	13316	79717575
SARS-CoV-2 test negative	51.98	14.37	16	13481	1355	79729536
Local anaesthetic systemic toxicity	47.27	14.37	14	13483	1040	79729851
Purpura	46.27	14.37	33	13464	19494	79711397
Hyperlipidaemia	43.99	14.37	36	13461	26057	79704834
Skin disorder	43.41	14.37	40	13457	33903	79696988
Colitis ulcerative	40.71	14.37	39	13458	34703	79696188
Appendicolith	39.33	14.37	22	13475	8529	79722362
Impaired work ability	39.30	14.37	30	13467	19651	79711240
Tracheal deviation	36.55	14.37	8	13489	173	79730718
Oral herpes	36.37	14.37	33	13464	27421	79703470
Proctalgia	36.13	14.37	22	13475	9979	79720912
Accident	36.00	14.37	21	13476	8810	79722081
Ventricular fibrillation	35.83	14.37	35	13462	31891	79699000
Frequent bowel movements	34.31	14.37	33	13464	29506	79701385
Oral candidiasis	34.22	14.37	33	13464	29595	79701296
Anaphylactic shock	34.08	14.37	36	13461	35960	79694931
Pyrexia	33.13	14.37	212	13285	678497	79052394
Constipation	32.90	14.37	114	13383	282936	79447955
Chemical burn	31.57	14.37	9	13488	584	79730307
Phrenic nerve paralysis	31.51	14.37	8	13489	333	79730558
Foreign body in respiratory tract	30.15	14.37	8	13489	397	79730494
Foreign body	30.12	14.37	13	13484	2881	79728010
Appendicitis	27.55	14.37	25	13472	20769	79710122
Methaemoglobinaemia	27.49	14.37	15	13482	5542	79725349
Cardiogenic shock	26.40	14.37	34	13463	41880	79689011
Completed suicide	26.05	14.37	5	13492	245762	79485129
Intentional dose omission	25.86	14.37	17	13480	8800	79722091
Herpes zoster	24.71	14.37	51	13446	93032	79637859
Kounis syndrome	22.41	14.37	12	13485	4270	79726621
Cardiac arrest	22.35	14.37	72	13425	172024	79558867
Rectal haemorrhage	21.67	14.37	43	13454	76257	79654634
Haemorrhoids	20.53	14.37	25	13472	29103	79701788
Colitis	20.44	14.37	41	13456	73266	79657625
Abdominal distension	19.26	14.37	54	13443	119596	79611295
Infusion related reaction	18.80	14.37	83	13414	230154	79500737
Haematochezia	18.71	14.37	44	13453	87601	79643290
Drug intolerance	18.32	14.37	11	13486	264108	79466783
Spinal operation	17.89	14.37	13	13484	7904	79722987
Cataract	17.63	14.37	35	13462	62085	79668806
Purtscher retinopathy	16.96	14.37	4	13493	122	79730769
Injection site infection	16.87	14.37	8	13489	2204	79728687
Cellulitis	16.36	14.37	48	13449	109012	79621879
Alopecia	15.54	14.37	10	13487	231345	79499546
Weight decreased	15.47	14.37	108	13389	355090	79375801
Ascites	15.12	14.37	37	13460	75525	79655366
Hepatic enzyme increased	15.10	14.37	6	13491	182604	79548287
Anaesthetic complication	14.93	14.37	8	13489	2851	79728040
Administration related reaction	14.38	14.37	4	13493	237	79730654

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.94	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tyrosinase	Enzyme	P14679	TYRO_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
G63QQF2NOX	UNII
4019467	VUID
N0000179319	NUI
D03015	KEGG_DRUG
4019467	VANDF
C0097513	UMLSCUI
CHEBI:134751	CHEBI
CHEMBL1200522	ChEMBL_ID
51040	PUBCHEM_CID
DB09495	DRUGBANK_ID
6480	INN_ID
C049935	MESH_SUPPLEMENTAL_RECORD_UI
C059933	MESH_SUPPLEMENTAL_RECORD_UI
45045	RXNORM
001976	NDDF
005097	NDDF
256171000	SNOMEDCT_US
422621002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.03 g	TOPICAL	OTC monograph final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.03 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.03 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.03 g	TOPICAL	OTC monograph final	8 sections
Daily Facial MoisturizerSPF 25	HUMAN OTC DRUG LABEL	4	0096-0721	CREAM	0.03 g	TOPICAL	OTC monograph final	11 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.01 g	TOPICAL	OTC monograph final	8 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.01 g	TOPICAL	OTC monograph final	8 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	30 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	30 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	3 g	TOPICAL	OTC monograph final	10 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	3 g	TOPICAL	OTC monograph final	10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	30 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	30 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4123	LOTION	3 g	TOPICAL	OTC monograph final	8 sections
Cetaphil Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4123	LOTION	3 g	TOPICAL	OTC monograph final	8 sections
Differin Oil Absorbing Moisturizer SPF 30	HUMAN OTC DRUG LABEL	3	0299-4133	LOTION	3 g	TOPICAL	OTC monograph final	9 sections
Cetaphil Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4134	LOTION	3 g	TOPICAL	OTC monograph final	8 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4136	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil PRO Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4313	LOTION	3 g	TOPICAL	OTC monograph final	8 sections
Differin Oil Absorbing Moisturizer SPF 30	HUMAN OTC DRUG LABEL	3	0299-4607	LOTION	3 g	TOPICAL	OTC monograph final	9 sections
Differin Oil Absorbing Moisturizer SPF 30	HUMAN OTC DRUG LABEL	3	0299-4607	LOTION	3 g	TOPICAL	OTC monograph final	9 sections
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	3 mg	TOPICAL	OTC monograph final	8 sections
Walgreens SPF 70 Sport Continuous	HUMAN OTC DRUG LABEL	4	0363-0035	SPRAY	30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0053	SPRAY	300 mg	TOPICAL	OTC monograph not final	13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0066	LOTION	27 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Sport Faces	HUMAN OTC DRUG LABEL	5	0363-0087	LOTION	30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Sport Faces	HUMAN OTC DRUG LABEL	4	0363-0090	LOTION	30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 30 Sport	HUMAN OTC DRUG LABEL	4	0363-0093	LOTION	30 mg	TOPICAL	OTC monograph not final	12 sections