avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4242 | 70356-09-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
causes allergic or photoallergic contact dermatitis; structure given in first source
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 7, 1992 | FDA | BAYER HEALTHCARE LLC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 609.76 | 17.97 | 166 | 4577 | 18742 | 56268582 |
| Therapy interrupted | 248.69 | 17.97 | 90 | 4653 | 25535 | 56261789 |
| Death | 139.96 | 17.97 | 157 | 4586 | 341269 | 55946055 |
| Therapy cessation | 138.41 | 17.97 | 60 | 4683 | 27204 | 56260120 |
| Chronic sinusitis | 106.38 | 17.97 | 36 | 4707 | 8342 | 56278982 |
| Paraesthesia oral | 87.27 | 17.97 | 36 | 4707 | 14413 | 56272911 |
| Drug ineffective | 81.96 | 17.97 | 213 | 4530 | 918776 | 55368548 |
| Procedural pain | 76.65 | 17.97 | 34 | 4709 | 16237 | 56271087 |
| Surgery | 72.87 | 17.97 | 41 | 4702 | 32445 | 56254879 |
| Hospitalisation | 70.58 | 17.97 | 55 | 4688 | 74945 | 56212379 |
| Therapeutic product effect incomplete | 40.12 | 17.97 | 47 | 4696 | 105984 | 56181340 |
| Tracheal deviation | 36.87 | 17.97 | 7 | 4736 | 151 | 56287173 |
| Intentional dose omission | 36.12 | 17.97 | 15 | 4728 | 6095 | 56281229 |
| Phrenic nerve paralysis | 35.55 | 17.97 | 7 | 4736 | 184 | 56287140 |
| Dyspepsia | 33.24 | 17.97 | 38 | 4705 | 83433 | 56203891 |
| Body tinea | 30.01 | 17.97 | 9 | 4734 | 1411 | 56285913 |
| Local anaesthetic systemic toxicity | 26.17 | 17.97 | 7 | 4736 | 727 | 56286597 |
| Inhibitory drug interaction | 25.58 | 17.97 | 9 | 4734 | 2335 | 56284989 |
| Pyrexia | 25.28 | 17.97 | 85 | 4658 | 418688 | 55868636 |
| Infection susceptibility increased | 24.07 | 17.97 | 9 | 4734 | 2774 | 56284550 |
| Jarisch-Herxheimer reaction | 21.14 | 17.97 | 5 | 4738 | 315 | 56287009 |
| Dermatophytosis | 18.38 | 17.97 | 4 | 4739 | 173 | 56287151 |
| Glucose tolerance impaired | 18.16 | 17.97 | 9 | 4734 | 5496 | 56281828 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 202.57 | 22.64 | 195 | 2485 | 360374 | 31334290 |
| Therapy interrupted | 148.42 | 22.64 | 49 | 2631 | 10547 | 31684117 |
| Therapy cessation | 96.01 | 22.64 | 39 | 2641 | 15016 | 31679648 |
| Surgery | 61.47 | 22.64 | 27 | 2653 | 12572 | 31682092 |
| Appendicolith | 40.48 | 22.64 | 16 | 2664 | 5715 | 31688949 |
| Hospitalisation | 37.25 | 22.64 | 32 | 2648 | 49775 | 31644889 |
| Appendicitis | 35.61 | 22.64 | 18 | 2662 | 11447 | 31683217 |
| Ventricular fibrillation | 27.28 | 22.64 | 18 | 2662 | 18830 | 31675834 |
| Ascites | 25.98 | 22.64 | 24 | 2656 | 40989 | 31653675 |
| Constipation | 24.21 | 22.64 | 40 | 2640 | 123951 | 31570713 |
| Stress | 22.75 | 22.64 | 18 | 2662 | 24923 | 31669741 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Therapy interrupted | 410.32 | 16.41 | 134 | 6645 | 24668 | 70896997 |
| Death | 377.50 | 16.41 | 341 | 6438 | 509720 | 70411945 |
| Therapy cessation | 233.82 | 16.41 | 96 | 6683 | 33580 | 70888085 |
| Surgery | 144.18 | 16.41 | 66 | 6713 | 29923 | 70891742 |
| Hospitalisation | 120.61 | 16.41 | 83 | 6696 | 82485 | 70839180 |
| Macular degeneration | 97.89 | 16.41 | 34 | 6745 | 7494 | 70914171 |
| Chronic sinusitis | 94.05 | 16.41 | 34 | 6745 | 8417 | 70913248 |
| Paraesthesia oral | 77.43 | 16.41 | 35 | 6744 | 15382 | 70906283 |
| Procedural pain | 66.26 | 16.41 | 33 | 6746 | 17976 | 70903689 |
| Intentional dose omission | 38.82 | 16.41 | 17 | 6762 | 6924 | 70914741 |
| Appendicolith | 38.70 | 16.41 | 16 | 6763 | 5664 | 70916001 |
| Therapeutic product effect incomplete | 36.73 | 16.41 | 51 | 6728 | 119831 | 70801834 |
| Tracheal deviation | 35.44 | 16.41 | 7 | 6772 | 164 | 70921501 |
| Local anaesthetic systemic toxicity | 33.30 | 16.41 | 9 | 6770 | 856 | 70920809 |
| Phrenic nerve paralysis | 30.96 | 16.41 | 7 | 6772 | 318 | 70921347 |
| Body tinea | 29.13 | 16.41 | 9 | 6770 | 1374 | 70920291 |
| Appendicitis | 27.19 | 16.41 | 18 | 6761 | 16715 | 70904950 |
| Spinal operation | 26.20 | 16.41 | 13 | 6766 | 7015 | 70914650 |
| Dyspepsia | 24.48 | 16.41 | 36 | 6743 | 89041 | 70832624 |
| Pyrexia | 22.65 | 16.41 | 116 | 6663 | 606836 | 70314829 |
| Infection susceptibility increased | 22.44 | 16.41 | 9 | 6770 | 2948 | 70918717 |
| Ventricular fibrillation | 21.47 | 16.41 | 19 | 6760 | 27092 | 70894573 |
| COVID-19 | 21.17 | 16.41 | 37 | 6742 | 105720 | 70815945 |
| Inhibitory drug interaction | 20.24 | 16.41 | 9 | 6770 | 3798 | 70917867 |
| Ascites | 19.57 | 16.41 | 28 | 6751 | 67519 | 70854146 |
| Knee operation | 17.82 | 16.41 | 9 | 6770 | 5038 | 70916627 |
| Cardiac pacemaker insertion | 17.29 | 16.41 | 9 | 6770 | 5363 | 70916302 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003358 | Cosmetics |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D011837 | Radiation-Protective Agents |
| MeSH PA | D013473 | Sunscreening Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.94 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosinase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| G63QQF2NOX | UNII |
| 4019467 | VUID |
| N0000179319 | NUI |
| D03015 | KEGG_DRUG |
| 4019467 | VANDF |
| C0097513 | UMLSCUI |
| CHEBI:134751 | CHEBI |
| CHEMBL1200522 | ChEMBL_ID |
| 51040 | PUBCHEM_CID |
| DB09495 | DRUGBANK_ID |
| 6480 | INN_ID |
| C049935 | MESH_SUPPLEMENTAL_RECORD_UI |
| C059933 | MESH_SUPPLEMENTAL_RECORD_UI |
| 45045 | RXNORM |
| 001976 | NDDF |
| 005097 | NDDF |
| 256171000 | SNOMEDCT_US |
| 422621002 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.03 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.03 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Avo SPF35 | HUMAN OTC DRUG LABEL | 4 | 0096-0687 | CREAM | 0.03 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Avo SPF35 | HUMAN OTC DRUG LABEL | 4 | 0096-0687 | CREAM | 0.03 g | TOPICAL | OTC monograph final | 8 sections |
| Daily Facial MoisturizerSPF 25 | HUMAN OTC DRUG LABEL | 4 | 0096-0721 | CREAM | 0.03 g | TOPICAL | OTC monograph final | 11 sections |
| Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.01 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.01 g | TOPICAL | OTC monograph final | 8 sections |
| Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 30 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 30 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Cetaphil | HUMAN OTC DRUG LABEL | 2 | 0299-3928 | LOTION | 3 g | TOPICAL | OTC monograph final | 10 sections |
| Cetaphil | HUMAN OTC DRUG LABEL | 2 | 0299-3928 | LOTION | 3 g | TOPICAL | OTC monograph final | 10 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 35 | HUMAN OTC DRUG LABEL | 4 | 0299-4113 | LOTION | 28 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 | HUMAN OTC DRUG LABEL | 4 | 0299-4118 | LOTION | 30 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 | HUMAN OTC DRUG LABEL | 4 | 0299-4118 | LOTION | 30 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4123 | LOTION | 3 g | TOPICAL | OTC monograph final | 8 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4123 | LOTION | 3 g | TOPICAL | OTC monograph final | 8 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4133 | LOTION | 3 g | TOPICAL | OTC monograph final | 9 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4134 | LOTION | 3 g | TOPICAL | OTC monograph final | 8 sections |
| Cetaphil PRO Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4313 | LOTION | 3 g | TOPICAL | OTC monograph final | 8 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4607 | LOTION | 3 g | TOPICAL | OTC monograph final | 9 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4607 | LOTION | 3 g | TOPICAL | OTC monograph final | 9 sections |
| Almay Anti Aging Lip Care SPF 20 | HUMAN OTC DRUG LABEL | 5 | 0311-0709 | LIPSTICK | 3 mg | TOPICAL | OTC monograph final | 8 sections |
| Walgreens SPF 70 Sport Continuous | HUMAN OTC DRUG LABEL | 4 | 0363-0035 | SPRAY | 30 mg | TOPICAL | OTC monograph not final | 12 sections |
| Hydrating Antioxidant Moiturizer | HUMAN OTC DRUG LABEL | 4 | 0363-0540 | CREAM | 2.48 g | TOPICAL | OTC monograph not final | 11 sections |
| Walgreens 7-in-1 Anti-Aging Vitamin Complex Broad Spectrum SPF 15 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0692 | CREAM | 3 mg | TOPICAL | OTC monograph not final | 12 sections |
| Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0696 | CREAM | 3 g | TOPICAL | OTC monograph not final | 12 sections |
| Walgreens Advanced Anti-Wrinkle and Firming Day Cream Broad Spectrum SPF18 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0815 | CREAM | 2 g | TOPICAL | OTC monograph not final | 11 sections |
| WALGREEN SPORT SPF 70 SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0900 | LOTION | 30 mg | TOPICAL | OTC monograph not final | 12 sections |
| WALGREENS SPORT SPF 50 SUNSCREEN | HUMAN OTC DRUG LABEL | 4 | 0363-0924 | AEROSOL, SPRAY | 30 mg | TOPICAL | OTC monograph not final | 13 sections |
| WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0933 | LOTION | 30 mg | TOPICAL | OTC monograph not final | 12 sections |