avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4242 70356-09-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avobenzone
  • butylmethoxydibenzoylmethane
  • photoplex
causes allergic or photoallergic contact dermatitis; structure given in first source
  • Molecular weight: 310.39
  • Formula: C20H22O3
  • CLOGP: 4.68
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -5.70
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 708.72 15.82 225 9275 24151 63455371
Chronic sinusitis 216.82 15.82 79 9421 12764 63466758
Paraesthesia oral 189.10 15.82 80 9420 19176 63460346
Therapy interrupted 178.00 15.82 90 9410 32365 63447157
Procedural pain 177.15 15.82 79 9421 21490 63458032
Body tinea 110.33 15.82 30 9470 1855 63477667
Vaginal flatulence 106.29 15.82 33 9467 3260 63476262
Therapy cessation 101.97 15.82 61 9439 30396 63449126
Inhibitory drug interaction 98.09 15.82 30 9470 2819 63476703
Proctitis 93.76 15.82 34 9466 5407 63474115
Radiculopathy 91.96 15.82 38 9462 8573 63470949
Infection susceptibility increased 91.83 15.82 30 9470 3491 63476031
Female genital tract fistula 89.77 15.82 36 9464 7523 63471999
Drug ineffective 89.61 15.82 349 9151 1044416 62435106
Therapeutic product effect incomplete 84.98 15.82 99 9401 124957 63354565
Glucose tolerance impaired 73.54 15.82 30 9470 6547 63472975
Vaginal discharge 73.27 15.82 33 9467 9165 63470357
Poor quality sleep 72.14 15.82 42 9458 19893 63459629
Dyspepsia 71.24 15.82 82 9418 102114 63377408
Death 69.89 15.82 165 9335 374216 63105306
Purpura 63.61 15.82 32 9468 11353 63468169
Impaired quality of life 57.85 15.82 32 9468 13751 63465771
Colitis ulcerative 57.05 15.82 40 9460 26051 63453471
Bone density decreased 53.43 15.82 31 9469 14581 63464941
Hyperlipidaemia 49.90 15.82 33 9467 19538 63459984
Impaired work ability 48.31 15.82 31 9469 17444 63462078
Surgery 47.76 15.82 41 9459 35871 63443651
Oral candidiasis 47.64 15.82 34 9466 22764 63456758
Frequent bowel movements 47.34 15.82 34 9466 22988 63456534
Skin disorder 44.01 15.82 36 9464 29471 63450051
Hospitalisation 42.79 15.82 58 9442 85023 63394499
Local anaesthetic systemic toxicity 42.03 15.82 12 9488 887 63478635
Removal of foreign body 41.18 15.82 7 9493 41 63479481
Oral herpes 39.28 15.82 32 9468 26042 63453480
Pyrexia 38.92 15.82 156 9344 470322 63009200
Tracheal deviation 38.42 15.82 8 9492 154 63479368
Rectal haemorrhage 36.95 15.82 41 9459 48989 63430533
Phrenic nerve paralysis 36.90 15.82 8 9492 188 63479334
Colitis 33.87 15.82 39 9461 48489 63431033
Weight decreased 33.38 15.82 104 9396 276694 63202828
Haematochezia 29.21 15.82 38 9462 53506 63426016
Herpes zoster 28.26 15.82 47 9453 82415 63397107
Cellulitis 27.14 15.82 46 9454 81912 63397610
Alopecia 24.40 15.82 10 9490 337526 63141996
Intentional dose omission 24.00 15.82 15 9485 8060 63471462
Foreign body in respiratory tract 23.07 15.82 6 9494 312 63479210
Drug intolerance 22.54 15.82 9 9491 308652 63170870
Infusion related reaction 21.50 15.82 83 9417 245438 63234084
Hepatic enzyme increased 20.38 15.82 3 9497 202325 63277197
Anaphylactic shock 19.96 15.82 21 9479 23612 63455910
Systemic lupus erythematosus 19.08 15.82 4 9496 208914 63270608
Cataract 18.85 15.82 32 9468 57021 63422501
Constipation 18.84 15.82 75 9425 224868 63254654
Purtscher retinopathy 18.45 15.82 4 9496 94 63479428
Rheumatoid arthritis 17.57 15.82 8 9492 253811 63225711
Jarisch-Herxheimer reaction 17.48 15.82 5 9495 372 63479150
Therapeutic product effect decreased 17.03 15.82 4 9496 193183 63286339
Chemical burn 16.89 15.82 5 9495 420 63479102
Foetal exposure during delivery 16.40 15.82 4 9496 160 63479362
Joint swelling 16.33 15.82 15 9485 327651 63151871

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 114.75 18.04 212 5163 397837 34553719
Therapy interrupted 107.51 18.04 49 5326 13648 34937908
Anal inflammation 72.35 18.04 20 5355 1280 34950276
Therapy cessation 69.20 18.04 39 5336 16934 34934622
SARS-CoV-2 test negative 62.84 18.04 17 5358 1003 34950553
Proctalgia 49.74 18.04 22 5353 5701 34945855
Accident 49.07 18.04 21 5354 5026 34946530
Surgery 43.22 18.04 27 5348 14130 34937426
Appendicolith 41.22 18.04 22 5353 8579 34942977
Ventricular fibrillation 39.96 18.04 31 5344 22923 34928633
Cardiogenic shock 35.93 18.04 31 5344 26587 34924969
Appendicitis 34.85 18.04 24 5351 14783 34936773
Removal of foreign body 34.74 18.04 6 5369 38 34951518
Haemorrhoids 30.53 18.04 22 5353 14553 34937003
Cardiac arrest 28.31 18.04 52 5323 96107 34855449
Body temperature increased 25.01 18.04 21 5354 17347 34934209
Stress 21.67 18.04 25 5350 30322 34921234
Ascites 21.64 18.04 31 5344 46540 34905016
Hospitalisation 20.96 18.04 34 5341 56868 34894688
Methaemoglobinaemia 19.55 18.04 10 5365 3571 34947985
Administration related reaction 18.14 18.04 4 5371 99 34951457

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 304.64 14.37 134 13363 31207 79699684
Death 214.77 14.37 360 13137 566154 79164737
Macular degeneration 202.32 14.37 75 13422 11221 79719670
Chronic sinusitis 195.46 14.37 76 13421 12950 79717941
Paraesthesia oral 174.83 14.37 80 13417 20391 79710500
Therapy cessation 174.00 14.37 97 13400 37465 79693426
Procedural pain 159.64 14.37 78 13419 23006 79707885
Body tinea 107.15 14.37 30 13467 1824 79729067
Vaginal flatulence 105.95 14.37 32 13465 2543 79728348
Surgery 103.14 14.37 66 13431 32700 79698191
Female genital tract fistula 90.10 14.37 35 13462 5940 79724951
Infection susceptibility increased 86.57 14.37 30 13467 3691 79727200
Inhibitory drug interaction 85.01 14.37 31 13466 4422 79726469
Proctitis 80.71 14.37 33 13464 6399 79724492
Radiculopathy 80.10 14.37 36 13461 8788 79722103
Hospitalisation 76.73 14.37 87 13410 94149 79636742
Therapeutic product effect incomplete 72.82 14.37 104 13393 141541 79589350
Vaginal discharge 72.73 14.37 32 13465 7431 79723460
Anal inflammation 64.15 14.37 19 13478 1411 79729480
Glucose tolerance impaired 64.03 14.37 30 13467 8054 79722837
Removal of foreign body 62.45 14.37 11 13486 71 79730820
Poor quality sleep 59.93 14.37 41 13456 22681 79708210
Dyspepsia 57.61 14.37 81 13416 108606 79622285
Impaired quality of life 52.89 14.37 32 13465 14354 79716537
Bone density decreased 52.48 14.37 31 13466 13316 79717575
SARS-CoV-2 test negative 51.98 14.37 16 13481 1355 79729536
Local anaesthetic systemic toxicity 47.27 14.37 14 13483 1040 79729851
Purpura 46.27 14.37 33 13464 19494 79711397
Hyperlipidaemia 43.99 14.37 36 13461 26057 79704834
Skin disorder 43.41 14.37 40 13457 33903 79696988
Colitis ulcerative 40.71 14.37 39 13458 34703 79696188
Appendicolith 39.33 14.37 22 13475 8529 79722362
Impaired work ability 39.30 14.37 30 13467 19651 79711240
Tracheal deviation 36.55 14.37 8 13489 173 79730718
Oral herpes 36.37 14.37 33 13464 27421 79703470
Proctalgia 36.13 14.37 22 13475 9979 79720912
Accident 36.00 14.37 21 13476 8810 79722081
Ventricular fibrillation 35.83 14.37 35 13462 31891 79699000
Frequent bowel movements 34.31 14.37 33 13464 29506 79701385
Oral candidiasis 34.22 14.37 33 13464 29595 79701296
Anaphylactic shock 34.08 14.37 36 13461 35960 79694931
Pyrexia 33.13 14.37 212 13285 678497 79052394
Constipation 32.90 14.37 114 13383 282936 79447955
Chemical burn 31.57 14.37 9 13488 584 79730307
Phrenic nerve paralysis 31.51 14.37 8 13489 333 79730558
Foreign body in respiratory tract 30.15 14.37 8 13489 397 79730494
Foreign body 30.12 14.37 13 13484 2881 79728010
Appendicitis 27.55 14.37 25 13472 20769 79710122
Methaemoglobinaemia 27.49 14.37 15 13482 5542 79725349
Cardiogenic shock 26.40 14.37 34 13463 41880 79689011
Completed suicide 26.05 14.37 5 13492 245762 79485129
Intentional dose omission 25.86 14.37 17 13480 8800 79722091
Herpes zoster 24.71 14.37 51 13446 93032 79637859
Kounis syndrome 22.41 14.37 12 13485 4270 79726621
Cardiac arrest 22.35 14.37 72 13425 172024 79558867
Rectal haemorrhage 21.67 14.37 43 13454 76257 79654634
Haemorrhoids 20.53 14.37 25 13472 29103 79701788
Colitis 20.44 14.37 41 13456 73266 79657625
Abdominal distension 19.26 14.37 54 13443 119596 79611295
Infusion related reaction 18.80 14.37 83 13414 230154 79500737
Haematochezia 18.71 14.37 44 13453 87601 79643290
Drug intolerance 18.32 14.37 11 13486 264108 79466783
Spinal operation 17.89 14.37 13 13484 7904 79722987
Cataract 17.63 14.37 35 13462 62085 79668806
Purtscher retinopathy 16.96 14.37 4 13493 122 79730769
Injection site infection 16.87 14.37 8 13489 2204 79728687
Cellulitis 16.36 14.37 48 13449 109012 79621879
Alopecia 15.54 14.37 10 13487 231345 79499546
Weight decreased 15.47 14.37 108 13389 355090 79375801
Ascites 15.12 14.37 37 13460 75525 79655366
Hepatic enzyme increased 15.10 14.37 6 13491 182604 79548287
Anaesthetic complication 14.93 14.37 8 13489 2851 79728040
Administration related reaction 14.38 14.37 4 13493 237 79730654

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
G63QQF2NOX UNII
4019467 VUID
N0000179319 NUI
D03015 KEGG_DRUG
4019467 VANDF
C0097513 UMLSCUI
CHEBI:134751 CHEBI
CHEMBL1200522 ChEMBL_ID
51040 PUBCHEM_CID
DB09495 DRUGBANK_ID
6480 INN_ID
C049935 MESH_SUPPLEMENTAL_RECORD_UI
C059933 MESH_SUPPLEMENTAL_RECORD_UI
45045 RXNORM
001976 NDDF
005097 NDDF
256171000 SNOMEDCT_US
422621002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.03 g TOPICAL OTC monograph final 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.01 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.01 g TOPICAL OTC monograph final 8 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 30 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 30 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 3 g TOPICAL OTC monograph final 10 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 3 g TOPICAL OTC monograph final 10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 28 mg TOPICAL OTC monograph final 12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 28 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 30 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 30 mg TOPICAL OTC monograph final 12 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 3 g TOPICAL OTC monograph final 8 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 3 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 3 g TOPICAL OTC monograph final 9 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4134 LOTION 3 g TOPICAL OTC monograph final 8 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 28 mg TOPICAL OTC monograph final 12 sections
Cetaphil PRO Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4313 LOTION 3 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 3 g TOPICAL OTC monograph final 9 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 3 g TOPICAL OTC monograph final 9 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 3 mg TOPICAL OTC monograph final 8 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 30 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen HUMAN OTC DRUG LABEL 4 0363-0053 SPRAY 300 mg TOPICAL OTC monograph not final 13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen HUMAN OTC DRUG LABEL 4 0363-0066 LOTION 27 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Sport Faces HUMAN OTC DRUG LABEL 5 0363-0087 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Sport Faces HUMAN OTC DRUG LABEL 4 0363-0090 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 30 Sport HUMAN OTC DRUG LABEL 4 0363-0093 LOTION 30 mg TOPICAL OTC monograph not final 12 sections