avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4242 70356-09-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avobenzone
  • butylmethoxydibenzoylmethane
  • photoplex
causes allergic or photoallergic contact dermatitis; structure given in first source
  • Molecular weight: 310.39
  • Formula: C20H22O3
  • CLOGP: 4.68
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -5.70
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 455.08 19.92 115 2807 14273 50587929
Therapy interrupted 303.88 19.92 90 2832 20062 50582140
Death 196.28 19.92 156 2766 325223 50276979
Therapy cessation 163.35 19.92 60 2862 25951 50576251
Hospitalisation 89.32 19.92 53 2869 67884 50534318
Surgery 87.30 19.92 40 2882 30165 50572037
Drug ineffective 53.07 19.92 133 2789 819200 49783002
Intentional dose omission 44.44 19.92 15 2907 5035 50597167
Chronic sinusitis 23.76 19.92 10 2912 6135 50596067
Jarisch-Herxheimer reaction 23.43 19.92 5 2917 290 50601912
COVID-19 22.84 19.92 20 2902 46642 50555560
Paraesthesia oral 22.73 19.92 12 2910 12209 50589993
Dermatophytosis 20.30 19.92 4 2918 156 50602046

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 247.13 23.81 189 1713 341895 29230730
Therapy interrupted 168.59 23.81 48 1854 8338 29564287
Therapy cessation 108.02 23.81 39 1863 14423 29558202
Surgery 70.43 23.81 27 1875 11752 29560873
Hospitalisation 47.38 23.81 32 1870 45956 29526669

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 477.77 18.53 335 4178 482370 64011849
Therapy interrupted 475.82 18.53 133 4380 19903 64474316
Therapy cessation 266.59 18.53 96 4417 32393 64461826
Surgery 164.55 18.53 65 4448 28148 64466071
Hospitalisation 146.35 18.53 81 4432 75126 64419093
Intentional dose omission 47.36 18.53 17 4496 5635 64488584
COVID-19 35.01 18.53 32 4481 65108 64429111
Spinal operation 31.79 18.53 13 4500 6120 64488099
Macular degeneration 29.24 18.53 12 4501 5698 64488521
Pneumonia 24.35 18.53 90 4423 559486 63934733
Knee operation 21.39 18.53 9 4504 4548 64489671
Cardiac pacemaker insertion 20.55 18.53 9 4504 5014 64489205
Chronic sinusitis 18.61 18.53 9 4504 6283 64487936

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
G63QQF2NOX UNII
4019467 VUID
N0000179319 NUI
D03015 KEGG_DRUG
4019467 VANDF
C0097513 UMLSCUI
CHEBI:134751 CHEBI
CHEMBL1200522 ChEMBL_ID
51040 PUBCHEM_CID
DB09495 DRUGBANK_ID
6480 INN_ID
C049935 MESH_SUPPLEMENTAL_RECORD_UI
C059933 MESH_SUPPLEMENTAL_RECORD_UI
45045 RXNORM
001976 NDDF
005097 NDDF
256171000 SNOMEDCT_US
422621002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.03 g TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.03 g TOPICAL OTC monograph final 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.01 g TOPICAL OTC monograph final 8 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 30 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 30 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 3 g TOPICAL OTC monograph final 10 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 3 g TOPICAL OTC monograph final 10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 28 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 30 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 30 mg TOPICAL OTC monograph final 12 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 3 g TOPICAL OTC monograph final 8 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 3 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 3 g TOPICAL OTC monograph final 9 sections
Cetaphil PRO Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4313 LOTION 3 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 3 g TOPICAL OTC monograph final 9 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 3 g TOPICAL OTC monograph final 9 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 3 mg TOPICAL OTC monograph final 8 sections
Hydrating Antioxidant Moiturizer HUMAN OTC DRUG LABEL 4 0363-0540 CREAM 2.48 g TOPICAL OTC monograph not final 11 sections
Walgreens 7-in-1 Anti-Aging Vitamin Complex Broad Spectrum SPF 15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0692 CREAM 3 mg TOPICAL OTC monograph not final 12 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 3 g TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Anti-Wrinkle and Firming Day Cream Broad Spectrum SPF18 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0815 CREAM 2 g TOPICAL OTC monograph not final 11 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
WALGREENS SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0924 AEROSOL, SPRAY 30 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0936 STICK 30 mg TOPICAL OTC monograph not final 11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0937 LOTION 30 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 20 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0943 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
Walgreens Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-0956 SPRAY 30 mg TOPICAL OTC monograph not final 12 sections