avobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4242	70356-09-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: avobenzone butylmethoxydibenzoylmethane photoplex	causes allergic or photoallergic contact dermatitis; structure given in first source Molecular weight: 310.39 Formula: C20H22O3 CLOGP: 4.68 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 43.37 ALOGS: -5.70 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

avobenzone
butylmethoxydibenzoylmethane
photoplex

causes allergic or photoallergic contact dermatitis; structure given in first source

Molecular weight: 310.39
Formula: C20H22O3
CLOGP: 4.68
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 43.37
ALOGS: -5.70
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	708.72	15.82	225	9275	24151	63455371
Chronic sinusitis	216.82	15.82	79	9421	12764	63466758
Paraesthesia oral	189.10	15.82	80	9420	19176	63460346
Therapy interrupted	178.00	15.82	90	9410	32365	63447157
Procedural pain	177.15	15.82	79	9421	21490	63458032
Body tinea	110.33	15.82	30	9470	1855	63477667
Vaginal flatulence	106.29	15.82	33	9467	3260	63476262
Therapy cessation	101.97	15.82	61	9439	30396	63449126
Inhibitory drug interaction	98.09	15.82	30	9470	2819	63476703
Proctitis	93.76	15.82	34	9466	5407	63474115

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	114.75	18.04	212	5163	397837	34553719
Therapy interrupted	107.51	18.04	49	5326	13648	34937908
Anal inflammation	72.35	18.04	20	5355	1280	34950276
Therapy cessation	69.20	18.04	39	5336	16934	34934622
SARS-CoV-2 test negative	62.84	18.04	17	5358	1003	34950553
Proctalgia	49.74	18.04	22	5353	5701	34945855
Accident	49.07	18.04	21	5354	5026	34946530
Surgery	43.22	18.04	27	5348	14130	34937426
Appendicolith	41.22	18.04	22	5353	8579	34942977
Ventricular fibrillation	39.96	18.04	31	5344	22923	34928633

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	304.64	14.37	134	13363	31207	79699684
Death	214.77	14.37	360	13137	566154	79164737
Macular degeneration	202.32	14.37	75	13422	11221	79719670
Chronic sinusitis	195.46	14.37	76	13421	12950	79717941
Paraesthesia oral	174.83	14.37	80	13417	20391	79710500
Therapy cessation	174.00	14.37	97	13400	37465	79693426
Procedural pain	159.64	14.37	78	13419	23006	79707885
Body tinea	107.15	14.37	30	13467	1824	79729067
Vaginal flatulence	105.95	14.37	32	13465	2543	79728348
Surgery	103.14	14.37	66	13431	32700	79698191

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.94	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tyrosinase	Enzyme	P14679	TYRO_HUMAN	INHIBITOR				CHEMBL	CHEMBL

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External reference:

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ID	Source
001976	NDDF
005097	NDDF
256171000	SNOMEDCT_US
4019467	VUID
4019467	VANDF
422621002	SNOMEDCT_US
45045	RXNORM
51040	PUBCHEM_CID
6480	INN_ID
C0097513	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	3 mg	TOPICAL	OTC monograph final	8 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	3 g	TOPICAL	OTC monograph final	10 sections
Cetaphil	HUMAN OTC DRUG LABEL	2	0299-3928	LOTION	3 g	TOPICAL	OTC monograph final	10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	30 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	30 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4136	LOTION	28 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4123	LOTION	3 g	TOPICAL	OTC monograph final	8 sections
Cetaphil Oil Absorbing SPF 30	HUMAN OTC DRUG LABEL	3	0299-4123	LOTION	3 g	TOPICAL	OTC monograph final	8 sections

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