octisalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 4241 118-60-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octisalate
  • octyl salicylate
  • Molecular weight: 250.34
  • Formula: C15H22O3
  • CLOGP: 5.91
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -4.02
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 730.37 15.93 224 8240 24152 63456406
Chronic sinusitis 225.77 15.93 79 8385 12764 63467794
Paraesthesia oral 198.06 15.93 80 8384 19176 63461382
Procedural pain 185.97 15.93 79 8385 21490 63459068
Body tinea 113.77 15.93 30 8434 1855 63478703
Drug ineffective 112.59 15.93 348 8116 1044417 62436141
Vaginal flatulence 110.05 15.93 33 8431 3260 63477298
Inhibitory drug interaction 101.51 15.93 30 8434 2819 63477739
Proctitis 97.60 15.93 34 8430 5407 63475151
Radiculopathy 96.21 15.93 38 8426 8573 63471985
Infection susceptibility increased 95.25 15.93 30 8434 3491 63477067
Therapeutic product effect incomplete 94.43 15.93 99 8365 124957 63355601
Female genital tract fistula 93.81 15.93 36 8428 7523 63473035
Dyspepsia 79.08 15.93 82 8382 102114 63378444
Vaginal discharge 76.94 15.93 33 8431 9165 63471393
Glucose tolerance impaired 76.91 15.93 30 8434 6547 63474011
Poor quality sleep 76.68 15.93 42 8422 19893 63460665
Purpura 67.12 15.93 32 8432 11353 63469205
Impaired quality of life 61.33 15.93 32 8432 13751 63466807
Bone density decreased 56.78 15.93 31 8433 14581 63465977
Colitis ulcerative 54.03 15.93 37 8427 26054 63454504
Hyperlipidaemia 53.40 15.93 33 8431 19538 63461020
Impaired work ability 51.61 15.93 31 8433 17444 63463114
Oral candidiasis 51.20 15.93 34 8430 22764 63457794
Frequent bowel movements 48.50 15.93 33 8431 22989 63457569
Skin disorder 45.49 15.93 35 8429 29472 63451086
Local anaesthetic systemic toxicity 43.41 15.93 12 8452 887 63479671
Oral herpes 42.56 15.93 32 8432 26042 63454516
Pyrexia 42.22 15.93 148 8316 470330 63010228
Removal of foreign body 41.99 15.93 7 8457 41 63480517
Tracheal deviation 39.34 15.93 8 8456 154 63480404
Weight decreased 37.84 15.93 101 8363 276697 63203861
Phrenic nerve paralysis 37.82 15.93 8 8456 188 63480370
Colitis 37.59 15.93 39 8425 48489 63432069
Rectal haemorrhage 35.48 15.93 38 8426 48992 63431566
Herpes zoster 32.35 15.93 47 8417 82415 63398143
Haematochezia 31.07 15.93 37 8427 53507 63427051
Cellulitis 26.90 15.93 43 8421 81915 63398643
Infusion related reaction 26.18 15.93 82 8382 245439 63235119
Foreign body in respiratory tract 23.76 15.93 6 8458 312 63480246
Anaphylactic shock 22.01 15.93 21 8443 23612 63456946
Cataract 21.62 15.93 32 8432 57021 63423537
Rheumatoid arthritis 21.35 15.93 4 8460 253815 63226743
Constipation 21.16 15.93 72 8392 224871 63255687
Alopecia 20.03 15.93 10 8454 337526 63143032
Nausea 19.93 15.93 187 8277 854284 62626274
Purtscher retinopathy 18.91 15.93 4 8460 94 63480464
Drug intolerance 18.53 15.93 9 8455 308652 63171906
Systemic lupus erythematosus 18.20 15.93 3 8461 208915 63271643
Jarisch-Herxheimer reaction 18.05 15.93 5 8459 372 63480186
Anaemia 17.92 15.93 82 8382 293348 63187210
Chemical burn 17.46 15.93 5 8459 420 63480138
Foetal exposure during delivery 16.86 15.93 4 8460 160 63480398
Dermatophytosis 16.23 15.93 4 8460 188 63480370

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 75.09 17.78 20 4663 1280 34950968
SARS-CoV-2 test negative 65.17 17.78 17 4666 1003 34951245
Proctalgia 52.66 17.78 22 4661 5701 34946547
Accident 48.46 17.78 20 4663 5027 34947221
Appendicolith 47.06 17.78 23 4660 8578 34943670
Cardiogenic shock 44.09 17.78 33 4650 26585 34925663
Ventricular fibrillation 43.79 17.78 31 4652 22923 34929325
Appendicitis 40.39 17.78 25 4658 14782 34937466
Removal of foreign body 35.56 17.78 6 4677 38 34952210
Haemorrhoids 33.28 17.78 22 4661 14553 34937695
Cardiac arrest 30.84 17.78 50 4633 96109 34856139
Body temperature increased 27.57 17.78 21 4662 17347 34934901
Ascites 26.63 17.78 32 4651 46539 34905709
Stress 24.52 17.78 25 4658 30322 34921926
Constipation 22.77 17.78 54 4629 136928 34815320
Hyponatraemia 21.25 17.78 39 4644 82652 34869596
Abdominal distension 20.92 17.78 32 4651 58460 34893788
Methaemoglobinaemia 20.86 17.78 10 4673 3571 34948677
Multiple organ dysfunction syndrome 19.53 17.78 36 4647 76530 34875718
Administration related reaction 18.69 17.78 4 4679 99 34952149
Blood phosphorus increased 18.46 17.78 12 4671 7709 34944539
Anaphylactic shock 18.38 17.78 16 4667 15925 34936323
Blood uric acid increased 18.35 17.78 13 4670 9611 34942637

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 208.16 14.76 74 11761 11222 79721331
Chronic sinusitis 205.20 14.76 76 11759 12950 79719603
Paraesthesia oral 184.95 14.76 80 11755 20391 79712162
Procedural pain 166.31 14.76 77 11758 23007 79709546
Body tinea 111.06 14.76 30 11805 1824 79730729
Vaginal flatulence 110.11 14.76 32 11803 2543 79730010
Female genital tract fistula 94.58 14.76 35 11800 5940 79726613
Infection susceptibility increased 90.44 14.76 30 11805 3691 79728862
Inhibitory drug interaction 88.99 14.76 31 11804 4422 79728131
Proctitis 84.92 14.76 33 11802 6399 79726154
Radiculopathy 84.66 14.76 36 11799 8788 79723765
Therapeutic product effect incomplete 83.59 14.76 104 11731 141541 79591012
Vaginal discharge 76.78 14.76 32 11803 7431 79725122
Glucose tolerance impaired 67.81 14.76 30 11805 8054 79724499
Anal inflammation 66.62 14.76 19 11816 1411 79731142
Dyspepsia 66.02 14.76 81 11754 108606 79623947
Poor quality sleep 64.85 14.76 41 11794 22681 79709872
Removal of foreign body 63.89 14.76 11 11824 71 79732482
Impaired quality of life 56.81 14.76 32 11803 14354 79718199
Bone density decreased 56.28 14.76 31 11804 13316 79719237
SARS-CoV-2 test negative 54.05 14.76 16 11819 1355 79731198
Hyperlipidaemia 50.43 14.76 37 11798 26056 79706497
Purpura 50.21 14.76 33 11802 19494 79713059
Local anaesthetic systemic toxicity 49.08 14.76 14 11821 1040 79731513
Appendicolith 44.93 14.76 23 11812 8528 79724025
Impaired work ability 42.83 14.76 30 11805 19651 79712902
Skin disorder 41.86 14.76 37 11798 33906 79698647
Oral herpes 40.14 14.76 33 11802 27421 79705132
Ventricular fibrillation 39.77 14.76 35 11800 31891 79700662
Constipation 39.07 14.76 111 11724 282939 79449614
Pyrexia 39.02 14.76 201 11634 678508 79054045
Proctalgia 38.82 14.76 22 11813 9979 79722574
Anaphylactic shock 38.07 14.76 36 11799 35960 79696593
Oral candidiasis 37.95 14.76 33 11802 29595 79702958
Tracheal deviation 37.60 14.76 8 11827 173 79732380
Colitis ulcerative 37.23 14.76 35 11800 34707 79697846
Frequent bowel movements 36.03 14.76 32 11803 29507 79703046
Accident 35.83 14.76 20 11815 8811 79723742
Cardiogenic shock 33.46 14.76 36 11799 41878 79690675
Chemical burn 32.74 14.76 9 11826 584 79731969
Phrenic nerve paralysis 32.56 14.76 8 11827 333 79732220
Appendicitis 32.52 14.76 26 11809 20768 79711785
Foreign body 31.77 14.76 13 11822 2881 79729672
Foreign body in respiratory tract 31.19 14.76 8 11827 397 79732156
Herpes zoster 29.48 14.76 51 11784 93032 79639521
Methaemoglobinaemia 29.35 14.76 15 11820 5542 79727011
Cardiac arrest 26.20 14.76 70 11765 172026 79560527
Completed suicide 26.03 14.76 3 11832 245764 79486789
Abdominal distension 25.00 14.76 55 11780 119595 79612958
Colitis 24.31 14.76 41 11794 73266 79659287
Kounis syndrome 23.90 14.76 12 11823 4270 79728283
Haemorrhoids 23.22 14.76 25 11810 29103 79703450
Infusion related reaction 23.17 14.76 81 11754 230156 79502397
Rectal haemorrhage 21.84 14.76 40 11795 76260 79656293
Haematochezia 21.46 14.76 43 11792 87602 79644951
Rheumatoid arthritis 20.97 14.76 3 11832 208467 79524086
Cataract 20.94 14.76 35 11800 62085 79670468
Weight decreased 20.18 14.76 105 11730 355093 79377460
Ascites 19.62 14.76 38 11797 75524 79657029
Nausea 19.44 14.76 222 11613 956974 78775579
Purtscher retinopathy 17.48 14.76 4 11831 122 79732431
Cellulitis 17.24 14.76 45 11790 109015 79623538
Abdominal pain 16.78 14.76 107 11728 389462 79343091
Myasthenia gravis 16.25 14.76 13 11822 10386 79722167
Anaesthetic complication 15.92 14.76 8 11827 2851 79729702
Malaise 15.56 14.76 125 11710 489744 79242809
Arthritis bacterial 15.49 14.76 12 11823 9154 79723399
Blood uric acid increased 15.35 14.76 14 11821 13346 79719207
Administration related reaction 14.91 14.76 4 11831 237 79732316

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.9 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4X49Y0596W UNII
4025698 VUID
N0000179486 NUI
D05226 KEGG_DRUG
4020295 VANDF
4025698 VANDF
C0304632 UMLSCUI
CHEBI:88639 CHEBI
CHEMBL1329203 ChEMBL_ID
8364 PUBCHEM_CID
DB11062 DRUGBANK_ID
7940 INN_ID
91327 RXNORM
006876 NDDF
29622009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 50 mg TOPICAL OTC monograph not final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 50 mg TOPICAL OTC monograph not final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 48 mg TOPICAL OTC monograph final 12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 48 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 50 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 50 mg TOPICAL OTC monograph final 12 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 5 g TOPICAL OTC monograph final 8 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 5 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 5 g TOPICAL OTC monograph final 9 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4134 LOTION 5 g TOPICAL OTC monograph final 8 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 48 mg TOPICAL OTC monograph final 12 sections
Cetaphil PRO Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4313 LOTION 5 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 5 g TOPICAL OTC monograph final 9 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 5 g TOPICAL OTC monograph final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 50 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 50 mg TOPICAL OTC monograph final 11 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 5 mg TOPICAL OTC monograph final 6 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 5 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC monograph final 7 sections
Blue Lizard Kids SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2062 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Kids SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2062 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Active SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2072 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Active SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2072 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sport SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2075 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sport SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2075 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections