octisalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4241 118-60-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octisalate
  • octyl salicylate
  • Molecular weight: 250.34
  • Formula: C15H22O3
  • CLOGP: 5.91
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -4.02
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 645.14 17.36 165 3566 18743 56269593
Drug ineffective 116.47 17.36 212 3519 918777 55369559
Chronic sinusitis 114.91 17.36 36 3695 8342 56279994
Paraesthesia oral 95.69 17.36 36 3695 14413 56273923
Procedural pain 84.55 17.36 34 3697 16237 56272099
Therapeutic product effect incomplete 49.56 17.36 47 3684 105984 56182352
Dyspepsia 40.90 17.36 38 3693 83433 56204903
Tracheal deviation 38.55 17.36 7 3724 151 56288185
Phrenic nerve paralysis 37.23 17.36 7 3724 184 56288152
Body tinea 32.15 17.36 9 3722 1411 56286925
Pyrexia 29.65 17.36 77 3654 418696 55869640
Local anaesthetic systemic toxicity 27.84 17.36 7 3724 727 56287609
Inhibitory drug interaction 27.70 17.36 9 3722 2335 56286001
Infection susceptibility increased 26.18 17.36 9 3722 2774 56285562
Jarisch-Herxheimer reaction 22.34 17.36 5 3726 315 56288021
Glucose tolerance impaired 20.22 17.36 9 3722 5496 56282840
Dermatophytosis 19.34 17.36 4 3727 173 56288163

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 45.72 20.52 16 1902 5715 31689711
Appendicitis 41.38 20.52 18 1900 11447 31683979
Constipation 34.73 20.52 40 1878 123951 31571475
Ascites 33.06 20.52 24 1894 40989 31654437
Ventricular fibrillation 30.14 20.52 17 1901 18831 31676595
Cardiogenic shock 27.41 20.52 17 1901 22391 31673035
Stress 25.74 20.52 17 1901 24924 31670502
Sepsis 23.92 20.52 37 1881 151892 31543534
Hyponatraemia 22.64 20.52 25 1893 73774 31621652
Abdominal distension 22.55 20.52 21 1897 50663 31644763
Multiple organ dysfunction syndrome 22.48 20.52 24 1894 68179 31627247

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic sinusitis 104.09 17.71 34 4984 8417 70915009
Macular degeneration 103.81 17.71 33 4985 7495 70915931
Paraesthesia oral 87.60 17.71 35 4983 15382 70908044
Procedural pain 72.52 17.71 32 4986 17977 70905449
Therapeutic product effect incomplete 49.15 17.71 51 4967 119831 70803595
Appendicolith 43.38 17.71 16 5002 5664 70917762
Tracheal deviation 37.54 17.71 7 5011 164 70923262
Local anaesthetic systemic toxicity 35.99 17.71 9 5009 856 70922570
Dyspepsia 33.13 17.71 36 4982 89041 70834385
Phrenic nerve paralysis 33.06 17.71 7 5011 318 70923108
Appendicitis 32.20 17.71 18 5000 16715 70906711
Body tinea 31.80 17.71 9 5009 1374 70922052
Pyrexia 30.42 17.71 103 4915 606849 70316577
Ascites 26.34 17.71 28 4990 67519 70855907
Infection susceptibility increased 25.07 17.71 9 5009 2948 70920478
Ventricular fibrillation 24.25 17.71 18 5000 27093 70896333
Inhibitory drug interaction 22.86 17.71 9 5009 3798 70919628
Constipation 22.64 17.71 53 4965 252385 70671041
Abdominal distension 22.30 17.71 32 4986 104637 70818789
Nausea 19.86 17.71 115 4903 851973 70071453
Cardiogenic shock 19.64 17.71 18 5000 36289 70887137
Impaired quality of life 18.27 17.71 10 5008 8906 70914520
Glucose tolerance impaired 17.84 17.71 9 5009 6797 70916629

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.9 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4X49Y0596W UNII
4025698 VUID
N0000179486 NUI
D05226 KEGG_DRUG
4020295 VANDF
4025698 VANDF
C0304632 UMLSCUI
CHEBI:88639 CHEBI
CHEMBL1329203 ChEMBL_ID
8364 PUBCHEM_CID
DB11062 DRUGBANK_ID
7940 INN_ID
91327 RXNORM
006876 NDDF
29622009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 50 mg TOPICAL OTC monograph not final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 50 mg TOPICAL OTC monograph not final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 48 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 50 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 50 mg TOPICAL OTC monograph final 12 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 5 g TOPICAL OTC monograph final 8 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 5 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 5 g TOPICAL OTC monograph final 9 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4134 LOTION 5 g TOPICAL OTC monograph final 8 sections
Cetaphil PRO Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4313 LOTION 5 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 5 g TOPICAL OTC monograph final 9 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 5 g TOPICAL OTC monograph final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 50 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 50 mg TOPICAL OTC monograph final 11 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 5 mg TOPICAL OTC monograph final 6 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 5 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC monograph final 7 sections
Blue Lizard Kids SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2062 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Active SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2072 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sport SPF 50 Sunscreen HUMAN OTC DRUG LABEL 3 0316-2075 LOTION 55.50 mg TOPICAL OTC monograph not final 9 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Hydrating Antioxidant Moiturizer HUMAN OTC DRUG LABEL 4 0363-0540 CREAM 4.72 g TOPICAL OTC monograph not final 11 sections
Walgreens 7-in-1 Anti-Aging Vitamin Complex Broad Spectrum SPF 15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0692 CREAM 5 mg TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Anti-Wrinkle and Firming Day Cream Broad Spectrum SPF18 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0815 CREAM 5 g TOPICAL OTC monograph not final 11 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 30 mg TOPICAL OTC monograph not final 12 sections
WALGREENS SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0924 AEROSOL, SPRAY 50 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 50 mg TOPICAL OTC monograph not final 12 sections