zinc oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4240 1314-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinc oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
  • Molecular weight: 81.38
  • Formula: OZn
  • CLOGP: -1.12
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 16, 2006 FDA DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1968.21 10.36 4403 492982 179323 62812314
Systemic lupus erythematosus 1863.95 10.36 4662 492723 204256 62787381
Glossodynia 1645.97 10.36 4040 493345 174836 62816801
Hand deformity 1355.02 10.36 3495 493890 155962 62835675
Arthropathy 1314.39 10.36 4435 492950 230357 62761280
Alopecia 1134.28 10.36 5437 491948 332099 62659538
Abdominal discomfort 1130.90 10.36 5241 492144 315644 62675993
Wound 1123.36 10.36 3313 494072 159950 62831687
Rheumatoid arthritis 1032.85 10.36 4329 493056 249490 62742147
Maternal exposure during pregnancy 1016.57 10.36 3905 493480 216157 62775480
Synovitis 926.25 10.36 3393 493992 183525 62808112
Completed suicide 894.02 10.36 64 497321 145609 62846028
Anti-cyclic citrullinated peptide antibody positive 855.60 10.36 2417 494968 113795 62877842
Pericarditis 851.75 10.36 2614 494771 128965 62862672
Contraindicated product administered 850.77 10.36 3668 493717 213980 62777657
Infusion related reaction 848.41 10.36 3989 493396 241532 62750105
Discomfort 826.33 10.36 3035 494350 164339 62827298
Swelling 821.60 10.36 4291 493094 271087 62720550
Joint swelling 803.56 10.36 4843 492542 322823 62668814
Toxicity to various agents 707.93 10.36 541 496844 246709 62744928
Pain 674.57 10.36 8795 488590 731833 62259804
Death 590.26 10.36 1285 496100 373096 62618541
Product use issue 543.89 10.36 3266 494119 217254 62774383
Duodenal ulcer perforation 542.18 10.36 1709 495676 85500 62906137
Rheumatoid factor positive 532.95 10.36 1663 495722 82743 62908894
Helicobacter infection 528.75 10.36 1765 495620 91020 62900617
Hepatic enzyme increased 480.07 10.36 2967 494418 199361 62792276
Arthralgia 452.94 10.36 6608 490777 563102 62428535
Drug intolerance 413.82 10.36 3960 493425 304701 62686936
Musculoskeletal stiffness 413.45 10.36 2668 494717 181950 62809687
Therapeutic product effect decreased 406.11 10.36 2748 494637 190439 62801198
Drug interaction 393.37 10.36 748 496637 228383 62763254
Intentional overdose 384.98 10.36 60 497325 74092 62917545
Treatment failure 373.23 10.36 2754 494631 196289 62795348
Psoriatic arthropathy 364.21 10.36 1552 495833 89968 62901669
Drug abuse 351.80 10.36 70 497315 72448 62919189
Exposure during pregnancy 324.60 10.36 2209 495176 153338 62838299
Febrile neutropenia 296.43 10.36 294 497091 118155 62873482
Hip arthroplasty 274.50 10.36 910 496475 46736 62944901
Hypersensitivity 270.42 10.36 3490 493895 289195 62702442
Knee arthroplasty 266.19 10.36 982 496403 53224 62938413
Suicide attempt 261.77 10.36 76 497309 60842 62930795
Disease progression 261.36 10.36 347 497038 122411 62869226
Acute kidney injury 250.96 10.36 1135 496250 262280 62729357
Cardiac arrest 246.51 10.36 217 497168 92328 62899309
Rheumatic fever 241.80 10.36 816 496569 42295 62949342
Depressed level of consciousness 239.64 10.36 93 497292 61985 62929652
Impaired healing 234.27 10.36 1490 495895 101052 62890585
Malignant neoplasm progression 230.50 10.36 183 497202 81938 62909699
Overdose 225.46 10.36 345 497040 114733 62876904
Nasopharyngitis 218.63 10.36 2993 494392 251264 62740373
Constipation 217.35 10.36 964 496421 223979 62767658
Diarrhoea 215.49 10.36 4131 493254 711235 62280402
C-reactive protein abnormal 212.98 10.36 819 496566 45277 62946360
Swollen joint count increased 209.81 10.36 691 496694 35363 62956274
Nausea 206.81 10.36 5110 492275 849361 62142276
Folliculitis 203.64 10.36 1088 496297 69229 62922408
Blister 199.21 10.36 1716 495669 128098 62863539
Neutropenia 198.90 10.36 703 496682 174302 62817335
Muscle injury 197.43 10.36 1023 496362 64322 62927315
Device expulsion 188.83 10.36 25 497360 34897 62956740
Red blood cell sedimentation rate abnormal 184.75 10.36 450 496935 19332 62972305
Asthenia 179.39 10.36 2031 495354 381573 62610064
Sedation 173.13 10.36 45 497340 38764 62952873
Sleep disorder due to general medical condition, insomnia type 172.92 10.36 839 496546 51378 62940259
Bradycardia 171.66 10.36 192 497193 73035 62918602
Hypotension 169.38 10.36 1345 496040 271259 62720378
Tremor 166.25 10.36 508 496877 131731 62859906
Hyponatraemia 165.39 10.36 397 496988 111503 62880134
Electrocardiogram QT prolonged 165.36 10.36 134 497251 59396 62932241
Somnolence 162.90 10.36 782 496603 177903 62813734
Irritable bowel syndrome 162.09 10.36 1154 496231 81258 62910379
Drug ineffective 161.77 10.36 9850 487535 1034915 61956722
Lactic acidosis 160.43 10.36 50 497335 38237 62953400
Lower respiratory tract infection 158.22 10.36 1659 495726 130648 62860989
Anxiety 157.05 10.36 1028 496357 216513 62775124
Hyperhidrosis 155.11 10.36 388 496997 107448 62884189
Sickle cell anaemia with crisis 149.80 10.36 209 497176 5794 62985843
Condition aggravated 146.25 10.36 4155 493230 398062 62593575
Cardiac failure 144.19 10.36 301 497084 88841 62902796
Dyspnoea 141.88 10.36 4022 493363 657291 62334346
Renal failure 141.53 10.36 461 496924 117191 62874446
Rash 141.14 10.36 5548 491837 555323 62436314
Agitation 140.81 10.36 156 497229 59601 62932036
Blood cholesterol increased 133.37 10.36 1222 496163 92810 62898827
Vomiting 132.34 10.36 3356 494029 556261 62435376
Liver injury 128.17 10.36 863 496522 59657 62931980
Neuropathy peripheral 128.15 10.36 458 496927 113209 62878428
Osteoarthritis 127.70 10.36 1224 496161 94119 62897518
Respiratory arrest 125.82 10.36 49 497336 32596 62959041
Drug reaction with eosinophilia and systemic symptoms 125.21 10.36 54 497331 33782 62957855
Rhabdomyolysis 121.98 10.36 99 497286 43852 62947785
Type 2 diabetes mellitus 121.91 10.36 888 496497 62980 62928657
Dizziness 120.74 10.36 2510 494875 427415 62564222
Multiple sclerosis relapse 120.45 10.36 121 497264 48357 62943280
Neoplasm progression 119.90 10.36 68 497317 36360 62955277
Tachycardia 119.13 10.36 498 496887 117658 62873979
Syncope 118.82 10.36 494 496891 116891 62874746
Cognitive disorder 116.48 10.36 160 497225 55655 62935982
Fatigue 115.91 10.36 8255 489130 879773 62111864
Intentional self-injury 114.17 10.36 30 497355 25657 62965980
Fibromyalgia 112.97 10.36 1043 496342 79377 62912260
Arthritis 111.32 10.36 1393 495992 114528 62877109
Intentional product use issue 111.15 10.36 1509 495876 126383 62865254
Sopor 110.44 10.36 20 497365 22144 62969493
Cardio-respiratory arrest 104.25 10.36 194 497191 59765 62931872
Serotonin syndrome 104.20 10.36 47 497338 28635 62963002
Pregnancy 103.93 10.36 566 496819 36270 62955367
Myalgia 102.88 10.36 698 496687 145831 62845806
Anaemia 102.73 10.36 1648 495737 291782 62699855
Feeling abnormal 102.15 10.36 711 496674 147681 62843956
Ill-defined disorder 100.46 10.36 1031 496354 80724 62910913
Balance disorder 99.99 10.36 333 497052 84089 62907548
Renal impairment 99.59 10.36 356 497029 87999 62903638
Thrombocytopenia 99.32 10.36 734 496651 150423 62841214
Hypoxia 99.14 10.36 199 497186 59593 62932044
Drug withdrawal syndrome 98.10 10.36 45 497340 27149 62964488
Hypoglycaemia 97.81 10.36 202 497183 59863 62931774
Live birth 97.54 10.36 429 496956 25201 62966436
Coma 96.95 10.36 226 497159 64138 62927499
Dehydration 96.04 10.36 881 496504 172473 62819164
Infection 93.52 10.36 2404 494981 226769 62764868
No adverse event 93.32 10.36 112 497273 41293 62950344
Vision blurred 92.30 10.36 388 496997 91536 62900101
Seizure 90.55 10.36 637 496748 131997 62859640
Chest discomfort 89.61 10.36 500 496885 109469 62882168
Blood pressure fluctuation 87.82 10.36 643 496742 45674 62945963
Metabolic acidosis 87.38 10.36 136 497249 44933 62946704
Peripheral swelling 86.37 10.36 2710 494675 263232 62728405
Respiratory failure 86.36 10.36 457 496928 101401 62890236
Drug dependence 86.04 10.36 42 497343 24441 62967196
Cardiac failure congestive 85.65 10.36 402 496983 92031 62899606
Joint effusion 85.34 10.36 311 497074 16749 62974888
Hepatic failure 85.19 10.36 92 497293 35564 62956073
Blood pressure diastolic abnormal 84.85 10.36 279 497106 14263 62977374
Blood glucose increased 84.42 10.36 353 497032 83403 62908234
Abortion spontaneous 84.29 10.36 646 496739 46549 62945088
Blood pressure systolic abnormal 83.71 10.36 263 497122 13123 62978514
Hyperglycaemia 83.42 10.36 124 497261 41743 62949894
Red blood cell sedimentation rate increased 81.35 10.36 607 496778 43375 62948262
Contusion 81.19 10.36 1638 495747 148406 62843231
Hallucination 80.55 10.36 195 497190 54622 62937015
Orthostatic hypotension 79.19 10.36 100 497285 36060 62955577
Intentional product misuse 78.69 10.36 231 497154 60686 62930951
Angioedema 78.36 10.36 161 497224 47804 62943833
Drug resistance 78.10 10.36 41 497344 22892 62968745
Insomnia 77.95 10.36 1201 496184 214051 62777586
Foot deformity 76.58 10.36 425 496960 27428 62964209
Encephalopathy 76.35 10.36 115 497270 38505 62953132
Palmar-plantar erythrodysaesthesia syndrome 75.69 10.36 43 497342 22972 62968665
White blood cell count decreased 75.28 10.36 711 496674 138393 62853244
Product quality issue 74.64 10.36 103 497282 35762 62955875
Product dose omission issue 73.85 10.36 1341 496044 232972 62758665
Sinusitis 73.66 10.36 2310 495075 224343 62767294
Disturbance in attention 73.31 10.36 116 497269 38073 62953564
Joint stiffness 73.05 10.36 570 496815 41299 62950338
Drug ineffective for unapproved indication 72.74 10.36 96 497289 33967 62957670
Disability assessment scale score increased 72.51 10.36 107 497278 3126 62988511
Sedation complication 72.14 10.36 11 497374 13811 62977826
Fluid retention 71.65 10.36 234 497151 59452 62932185
Neutrophil count decreased 71.34 10.36 216 497169 56190 62935447
Altered state of consciousness 71.05 10.36 56 497329 25174 62966463
Drug hypersensitivity 70.60 10.36 1873 495512 308814 62682823
Multiple organ dysfunction syndrome 70.58 10.36 219 497166 56533 62935104
Blood pressure systolic increased 69.74 10.36 621 496764 46776 62944861
Pulmonary embolism 69.47 10.36 582 496803 116102 62875535
Muscle spasms 68.83 10.36 837 496548 155313 62836324
Depression 67.56 10.36 1107 496278 195385 62796252
Psoriasis 67.51 10.36 1006 496379 85951 62905686
Inflammation 67.50 10.36 961 496424 81312 62910325
Hepatic function abnormal 67.41 10.36 117 497268 37025 62954612
Pulmonary fibrosis 67.28 10.36 538 496847 39271 62952366
Creatinine renal clearance decreased 67.07 10.36 22 497363 16286 62975351
Myocardial infarction 67.07 10.36 482 496903 99411 62892226
Stomatitis 66.49 10.36 1488 495897 137237 62854400
Ejection fraction decreased 66.19 10.36 47 497338 22285 62969352
Platelet count decreased 66.09 10.36 586 496799 115536 62876101
Asthma 66.07 10.36 659 496726 126902 62864735
Grip strength decreased 65.96 10.36 347 497038 21940 62969697
Metastases to bone 65.30 10.36 42 497343 20977 62970660
C-reactive protein increased 64.55 10.36 1072 496313 93635 62898002
Emotional distress 64.27 10.36 97 497288 32452 62959185
Mental status changes 63.77 10.36 134 497251 39465 62952172
Hyperkalaemia 63.35 10.36 215 497170 53988 62937649
Bone erosion 63.25 10.36 291 497094 17426 62974211
Suicidal ideation 62.95 10.36 263 497122 62158 62929479
Basal cell carcinoma 62.18 10.36 404 496981 27587 62964050
Loss of consciousness 62.10 10.36 608 496777 117513 62874124
Osteoporosis 61.13 10.36 703 496682 56635 62935002
Leukopenia 61.02 10.36 355 497030 76935 62914702
Palpitations 60.75 10.36 577 496808 112193 62879444
Juvenile idiopathic arthritis 60.55 10.36 100 497285 3226 62988411
Cholestasis 59.79 10.36 86 497299 29348 62962289
Dysphagia 59.68 10.36 427 496958 88158 62903479
Hepatocellular injury 59.67 10.36 76 497309 27305 62964332
Flushing 59.21 10.36 345 497040 74742 62916895
Mydriasis 59.11 10.36 11 497374 11945 62979692
Joint range of motion decreased 59.09 10.36 446 496939 31982 62959655
Restlessness 58.90 10.36 87 497298 29366 62962271
Muscle spasticity 58.13 10.36 51 497334 21743 62969894
Weight increased 58.06 10.36 2548 494837 258244 62733393
Blood pressure decreased 57.78 10.36 287 497098 64735 62926902
Drug tolerance decreased 57.29 10.36 280 497105 17193 62974444
Anaphylactic reaction 56.90 10.36 295 497090 65805 62925832
Joint laxity 55.92 10.36 82 497303 2382 62989255
Diabetic ketoacidosis 55.89 10.36 47 497338 20458 62971179
Wrong technique in product usage process 55.49 10.36 275 497110 62065 62929572
Poisoning 55.44 10.36 19 497366 13681 62977956
Loss of personal independence in daily activities 55.25 10.36 1070 496315 96220 62895417
Joint destruction 54.98 10.36 139 497246 6113 62985524
Bone pain 54.61 10.36 231 497154 54410 62937227
Disorientation 54.36 10.36 145 497240 39307 62952330
Musculoskeletal pain 54.16 10.36 1020 496365 91257 62900380
Dysgeusia 54.10 10.36 186 497199 46524 62945113
Blood alkaline phosphatase increased 54.00 10.36 165 497220 42802 62948835
Unresponsive to stimuli 53.98 10.36 115 497270 33701 62957936
Drug level increased 53.94 10.36 59 497326 22677 62968960
Hypokalaemia 53.86 10.36 536 496849 103268 62888369
Dysarthria 53.69 10.36 164 497221 42547 62949090
Blood creatine phosphokinase increased 53.30 10.36 98 497287 30332 62961305
Pulmonary arterial hypertension 53.11 10.36 59 497326 22518 62969119
Blood calcium decreased 53.03 10.36 78 497307 26373 62965264
Ventricular tachycardia 52.99 10.36 47 497338 19932 62971705
Gamma-glutamyltransferase increased 52.45 10.36 118 497267 33913 62957724
Caesarean section 52.35 10.36 268 497117 16764 62974873
Shock 52.31 10.36 64 497321 23399 62968238
Deep vein thrombosis 51.68 10.36 414 496971 83386 62908251
Blood bilirubin increased 51.55 10.36 136 497249 37004 62954633
Atrial fibrillation 51.46 10.36 625 496760 116011 62875626
Dyspnoea exertional 51.41 10.36 270 497115 60032 62931605
Cytokine release syndrome 51.15 10.36 24 497361 14290 62977347
Metastases to liver 51.11 10.36 66 497319 23573 62968064
Speech disorder 51.07 10.36 156 497229 40473 62951164
Osteonecrosis of jaw 50.77 10.36 126 497259 34997 62956640
Hospitalisation 49.90 10.36 426 496959 84655 62906982
Blood pressure diastolic decreased 49.39 10.36 326 497059 22380 62969257
Polyarthritis 49.10 10.36 183 497202 9963 62981674
Respiratory depression 49.00 10.36 23 497362 13692 62977945
Ascites 48.66 10.36 160 497225 40568 62951069
Disability 48.48 10.36 277 497108 18070 62973567
Fall 48.22 10.36 2547 494838 389787 62601850
Rheumatoid nodule 47.98 10.36 263 497122 16892 62974745
Pain in jaw 47.85 10.36 177 497208 43319 62948318
Cerebral haemorrhage 47.81 10.36 106 497279 30623 62961014
Acute hepatic failure 47.55 10.36 44 497341 18283 62973354
Cerebrovascular accident 47.22 10.36 580 496805 107444 62884193
Abnormal behaviour 47.18 10.36 59 497326 21367 62970270
Foetal exposure during pregnancy 47.14 10.36 419 496966 31543 62960094
Device dislocation 46.62 10.36 81 497304 25624 62966013
Adverse event 46.50 10.36 766 496619 66793 62924844
Extrapyramidal disorder 46.36 10.36 23 497362 13261 62978376
Anaphylactic shock 46.11 10.36 71 497314 23562 62968075
Premature labour 45.84 10.36 207 497178 12297 62979340
Cytomegalovirus infection 45.82 10.36 58 497327 20894 62970743
Vertigo 45.72 10.36 278 497107 59609 62932028
Haemorrhage 45.68 10.36 285 497100 60737 62930900
Injection site erythema 45.29 10.36 909 496476 82265 62909372
Torsade de pointes 45.27 10.36 24 497361 13327 62978310
Back pain 44.74 10.36 1655 495730 262490 62729147
Chronic kidney disease 44.71 10.36 193 497192 45205 62946432
Urticaria 44.64 10.36 974 496411 164828 62826809
Posterior reversible encephalopathy syndrome 44.58 10.36 42 497343 17303 62974334
Dyskinesia 44.56 10.36 117 497268 31885 62959752
Gestational diabetes 44.51 10.36 156 497229 8240 62983397
Injection site pruritus 44.50 10.36 545 496840 44571 62947066
Dry skin 43.99 10.36 263 497122 56624 62935013
Infective pulmonary exacerbation of cystic fibrosis 43.83 10.36 8 497377 8809 62982828
General physical health deterioration 43.75 10.36 1963 495422 199439 62792198
COVID-19 43.69 10.36 623 496762 112480 62879157
Respiratory disorder 43.67 10.36 158 497227 38924 62952713
Disseminated intravascular coagulation 43.50 10.36 51 497334 19000 62972637
Device difficult to use 43.39 10.36 23 497362 12773 62978864
Pulmonary oedema 43.33 10.36 252 497133 54621 62937016
Memory impairment 43.25 10.36 566 496819 103692 62887945
Pleural effusion 43.22 10.36 494 496891 92716 62898921
Psychotic disorder 43.11 10.36 85 497300 25627 62966010
Tuberculosis 42.92 10.36 188 497197 11023 62980614
Aspartate aminotransferase increased 42.82 10.36 476 496909 89801 62901836
Decreased appetite 42.73 10.36 1572 495813 249480 62742157
Hypothermia 42.38 10.36 27 497358 13554 62978083
Product administration error 42.08 10.36 69 497316 22328 62969309
Chest pain 41.69 10.36 1331 496054 214628 62777009
Schizophrenia 41.68 10.36 13 497372 9939 62981698
Neck deformity 41.65 10.36 66 497319 2055 62989582
Sepsis 41.08 10.36 900 496485 152223 62839414
Arrhythmia 40.78 10.36 157 497228 37983 62953654
Product use in unapproved indication 40.51 10.36 1080 496305 178000 62813637
Polyneuropathy 40.31 10.36 33 497352 14556 62977081
Inappropriate antidiuretic hormone secretion 40.26 10.36 37 497348 15425 62976212
Akathisia 40.04 10.36 11 497374 9135 62982502
Coagulopathy 39.81 10.36 62 497323 20482 62971155
Gastrointestinal disorder 39.58 10.36 1326 496059 129913 62861724
Blood creatinine increased 39.39 10.36 469 496916 87375 62904262
Neurotoxicity 39.31 10.36 45 497340 16945 62974692
Ventricular fibrillation 39.27 10.36 22 497363 11845 62979792
Gastrointestinal haemorrhage 38.90 10.36 427 496958 80749 62910888
Multiple fractures 38.88 10.36 152 497233 8466 62983171
Mobility decreased 38.82 10.36 1233 496152 119926 62871711
Joint injury 38.75 10.36 378 497007 29194 62962443
Depressed mood 38.28 10.36 173 497212 40018 62951619
Hemiparesis 38.15 10.36 78 497307 23204 62968433
Bronchospasm 37.61 10.36 48 497337 17232 62974405
Neuroleptic malignant syndrome 37.57 10.36 24 497361 12032 62979605
Lethargy 37.22 10.36 271 497114 55736 62935901
Withdrawal syndrome 37.20 10.36 62 497323 19935 62971702
Injection site reaction 37.17 10.36 655 496730 57869 62933768
Irritability 36.84 10.36 126 497259 31568 62960069
Respiratory distress 36.79 10.36 139 497246 33812 62957825
Maternal drugs affecting foetus 36.54 10.36 107 497278 5135 62986502
Laryngitis 36.54 10.36 243 497142 16724 62974913
Pulmonary hypertension 36.44 10.36 158 497227 36965 62954672
Alanine aminotransferase increased 36.17 10.36 583 496802 103187 62888450
Melaena 35.78 10.36 120 497265 30245 62961392
Brain oedema 35.75 10.36 35 497350 14160 62977477
Disease recurrence 35.68 10.36 107 497278 27923 62963714
Hypomagnesaemia 35.65 10.36 111 497274 28626 62963011
Acute respiratory failure 35.57 10.36 144 497241 34341 62957296
Hypomania 35.52 10.36 4 497381 6326 62985311
Accidental exposure to product 35.33 10.36 104 497281 27301 62964336
Pancreatitis acute 35.09 10.36 103 497282 27063 62964574
Joint dislocation 35.06 10.36 260 497125 18540 62973097
Maternal exposure before pregnancy 35.03 10.36 135 497250 7468 62984169
Enthesopathy 34.94 10.36 147 497238 8467 62983170
Nodule 34.89 10.36 283 497102 20743 62970894
Myelosuppression 34.28 10.36 85 497300 23618 62968019
Plasma cell myeloma 33.93 10.36 155 497230 35750 62955887
Muscle twitching 33.86 10.36 64 497321 19604 62972033
Immune reconstitution inflammatory syndrome 33.75 10.36 4 497381 6080 62985557
Parkinsonism 33.62 10.36 20 497365 10419 62981218
Stress cardiomyopathy 33.53 10.36 16 497369 9434 62982203
Acute generalised exanthematous pustulosis 33.37 10.36 23 497362 11076 62980561
Haematotoxicity 33.07 10.36 16 497369 9360 62982277
Thrombotic microangiopathy 32.95 10.36 21 497364 10540 62981097
Mania 32.91 10.36 29 497356 12338 62979299
Exposure to toxic agent 32.73 10.36 3 497382 5584 62986053
Blood potassium decreased 32.65 10.36 194 497191 41832 62949805
Heart rate decreased 32.63 10.36 520 496865 45040 62946597
Eosinophilia 32.60 10.36 82 497303 22674 62968963
Headache 32.58 10.36 4406 492979 628835 62362802
Facet joint syndrome 32.56 10.36 184 497201 11954 62979683
Blood pressure diastolic increased 32.52 10.36 160 497225 9850 62981787
Atrioventricular block complete 32.44 10.36 12 497373 8239 62983398
Panic attack 32.36 10.36 80 497305 22251 62969386
Second primary malignancy 32.23 10.36 11 497374 7942 62983695
Metastases to central nervous system 32.22 10.36 33 497352 13072 62978565
Ventricular septal defect 32.10 10.36 91 497294 4287 62987350
Unevaluable event 32.08 10.36 253 497132 51133 62940504
Diabetes mellitus inadequate control 31.92 10.36 43 497342 15083 62976554
Nightmare 31.71 10.36 64 497321 19130 62972507
Lupus-like syndrome 31.70 10.36 217 497168 15078 62976559
Ankylosing spondylitis 31.63 10.36 164 497221 10310 62981327
Localised infection 31.57 10.36 369 497016 29841 62961796
Dystonia 31.54 10.36 37 497348 13782 62977855
Fear 31.11 10.36 47 497338 15719 62975918
Obesity 30.93 10.36 365 497020 29587 62962050
Aphasia 30.86 10.36 143 497242 32857 62958780
Tenderness 30.77 10.36 291 497094 22287 62969350
International normalised ratio increased 30.67 10.36 225 497160 46200 62945437
Status epilepticus 30.46 10.36 45 497340 15188 62976449
Face oedema 30.40 10.36 71 497314 20141 62971496
Paraesthesia 30.37 10.36 967 496418 155999 62835638
Prescribed underdose 30.30 10.36 361 497024 29328 62962309
Transplant rejection 30.26 10.36 24 497361 10756 62980881
Therapy non-responder 30.25 10.36 794 496591 75107 62916530
Peripheral venous disease 29.98 10.36 216 497169 15261 62976376
Skin ulcer 29.97 10.36 489 496896 42556 62949081
Pain in extremity 29.94 10.36 3000 494385 328486 62663151
Cytopenia 29.92 10.36 28 497357 11573 62980064
Sinus tachycardia 29.92 10.36 94 497291 24174 62967463
Proteinuria 29.81 10.36 66 497319 19079 62972558
Wheelchair user 29.77 10.36 113 497272 6206 62985431
Accidental overdose 29.65 10.36 89 497296 23220 62968417
Rash erythematous 29.56 10.36 203 497182 42307 62949330
Tenosynovitis 29.36 10.36 197 497188 13598 62978039
Obstructive airways disorder 29.34 10.36 75 497310 20624 62971013
Metastases to lung 29.25 10.36 34 497351 12716 62978921
Latent tuberculosis 29.19 10.36 64 497321 2563 62989074
Limb deformity 29.16 10.36 83 497302 3919 62987718
Agranulocytosis 29.16 10.36 100 497285 25034 62966603
Paralysis 29.13 10.36 21 497364 9879 62981758
Hypervolaemia 29.08 10.36 119 497266 28294 62963343
Aggression 28.98 10.36 91 497294 23407 62968230
Lip swelling 28.82 10.36 135 497250 30928 62960709
Small for dates baby 28.51 10.36 79 497306 3672 62987965
Glycosylated haemoglobin increased 28.51 10.36 33 497352 12365 62979272
Skin exfoliation 28.42 10.36 209 497176 42893 62948744
Jaundice 28.41 10.36 125 497260 29126 62962511
Miosis 28.39 10.36 11 497374 7342 62984295
Rhinitis allergic 28.30 10.36 30 497355 11697 62979940
Pre-eclampsia 28.27 10.36 144 497241 8989 62982648
Leukocytosis 28.22 10.36 106 497279 25829 62965808
Abdominal distension 28.10 10.36 493 496892 86122 62905515
Dislocation of vertebra 28.04 10.36 138 497247 8497 62983140
Asphyxia 27.89 10.36 7 497378 6174 62985463
Myoclonus 27.88 10.36 51 497334 15817 62975820
Tumour lysis syndrome 27.88 10.36 18 497367 8972 62982665
Toxic skin eruption 27.83 10.36 36 497349 12849 62978788
Tardive dyskinesia 27.79 10.36 16 497369 8486 62983151
Lip dry 27.75 10.36 212 497173 15258 62976379
Angina pectoris 27.74 10.36 131 497254 29947 62961690
Bradyphrenia 27.70 10.36 10 497375 6970 62984667
Crying 27.68 10.36 92 497293 23251 62968386
Hyperlipidaemia 27.67 10.36 71 497314 19500 62972137
Injection site swelling 27.61 10.36 525 496860 47047 62944590
Premature rupture of membranes 27.54 10.36 94 497291 4899 62986738
Haemorrhage intracranial 27.46 10.36 39 497346 13380 62978257
Multiple allergies 27.37 10.36 41 497344 13761 62977876
Prescribed overdose 27.23 10.36 397 496988 33756 62957881
Infusion site pain 27.23 10.36 57 497328 16812 62974825
Stevens-Johnson syndrome 27.13 10.36 102 497283 24848 62966789
Cerebral infarction 27.09 10.36 96 497289 23797 62967840
Substance abuse 27.07 10.36 3 497382 4804 62986833
Malignant mediastinal neoplasm 27.03 10.36 44 497341 1402 62990235
Device use error 27.03 10.36 6 497379 5755 62985882
Cardiogenic shock 26.97 10.36 63 497322 17869 62973768
Multiple sclerosis 26.92 10.36 99 497286 24273 62967364
Retinitis 26.92 10.36 108 497277 6088 62985549
Complication associated with device 26.88 10.36 58 497327 16920 62974717
Sleep apnoea syndrome 26.80 10.36 127 497258 29006 62962631
Tenosynovitis stenosans 26.72 10.36 72 497313 3292 62988345
Genital haemorrhage 26.65 10.36 12 497373 7320 62984317
Lymphocyte count decreased 26.62 10.36 134 497251 30123 62961514
Anhedonia 26.57 10.36 28 497357 10946 62980691
Red blood cell sedimentation rate 26.43 10.36 91 497294 4763 62986874
Cough 26.41 10.36 1955 495430 290788 62700849
Post transplant lymphoproliferative disorder 26.26 10.36 4 497381 5027 62986610
Subdural haematoma 26.12 10.36 45 497340 14283 62977354
Abdominal pain 26.12 10.36 1962 495423 291494 62700143
Haemophagocytic lymphohistiocytosis 25.85 10.36 27 497358 10600 62981037
Maternal exposure timing unspecified 25.74 10.36 117 497268 6970 62984667
Urinary retention 25.64 10.36 136 497249 30165 62961472
Anti-cyclic citrullinated peptide antibody 25.62 10.36 113 497272 6645 62984992
Pancreatitis 25.56 10.36 253 497132 48802 62942835
Hypophagia 25.51 10.36 142 497243 31117 62960520
Ischaemic stroke 25.50 10.36 65 497320 17892 62973745
Wound infection 25.33 10.36 268 497117 21142 62970495
Chills 25.30 10.36 685 496700 112693 62878944
Blood glucose decreased 25.24 10.36 82 497303 20870 62970767
Therapeutic response decreased 25.21 10.36 646 496739 60879 62930758
Device related infection 25.20 10.36 96 497289 23296 62968341
Tachypnoea 25.06 10.36 62 497323 17240 62974397
Body temperature decreased 24.82 10.36 256 497129 20063 62971574
Swollen tongue 24.78 10.36 165 497220 34635 62957002
Hot flush 24.55 10.36 269 497116 50890 62940747
Dysmorphism 24.46 10.36 55 497330 2241 62989396
Uterine perforation 24.38 10.36 12 497373 6951 62984686
Smear cervix abnormal 24.36 10.36 64 497321 2882 62988755
Adjustment disorder with depressed mood 24.35 10.36 150 497235 10054 62981583
Acute graft versus host disease 24.35 10.36 3 497382 4425 62987212
Hallucination, visual 24.32 10.36 74 497311 19224 62972413
Haemoptysis 24.27 10.36 129 497256 28597 62963040
Product adhesion issue 24.08 10.36 4 497381 4715 62986922
Feeling hot 24.07 10.36 265 497120 50089 62941548
Nervousness 24.06 10.36 143 497242 30836 62960801
Synovial cyst 24.04 10.36 152 497233 10281 62981356
Deep vein thrombosis postoperative 23.98 10.36 162 497223 11207 62980430
Temperature regulation disorder 23.97 10.36 9 497376 6123 62985514
Cardiomyopathy 23.94 10.36 65 497320 17519 62974118
Breast cancer stage I 23.93 10.36 12 497373 6877 62984760
Psychomotor hyperactivity 23.86 10.36 29 497356 10634 62981003
Clostridium difficile colitis 23.75 10.36 82 497303 20487 62971150
Complication of device insertion 23.65 10.36 15 497370 7549 62984088
Acute myeloid leukaemia 23.64 10.36 63 497322 17084 62974553
Acidosis 23.63 10.36 32 497353 11201 62980436
Hallucination, auditory 23.63 10.36 40 497345 12784 62978853
Femur fracture 23.61 10.36 459 496926 41297 62950340
Infusion site swelling 23.57 10.36 25 497360 9745 62981892
Erythema multiforme 23.46 10.36 27 497358 10142 62981495
Synovial fluid analysis 23.42 10.36 56 497329 2377 62989260
Haematoma 23.36 10.36 168 497217 34652 62956985
Oedema peripheral 23.28 10.36 1230 496155 188281 62803356
Mental disorder 23.25 10.36 114 497271 25805 62965832
Device breakage 23.17 10.36 34 497351 11508 62980129
Graft versus host disease 23.16 10.36 12 497373 6751 62984886
Hypothyroidism 23 10.36 218 497167 42414 62949223
Muscle rigidity 22.96 10.36 34 497351 11466 62980171
Colitis 22.96 10.36 256 497129 48272 62943365
Lymphoedema 22.93 10.36 35 497350 11657 62979980
Complication of device removal 22.86 10.36 6 497379 5136 62986501
Atrioventricular block 22.79 10.36 16 497369 7631 62984006
Neck mass 22.72 10.36 71 497314 3532 62988105
Muscular weakness 22.66 10.36 758 496627 121595 62870042
Bursitis 22.61 10.36 412 496973 36629 62955008
Paradoxical drug reaction 22.38 10.36 3 497382 4149 62987488
Cholecystitis chronic 22.33 10.36 29 497356 10332 62981305
Cardiac failure acute 22.27 10.36 25 497360 9498 62982139
Urinary incontinence 22.20 10.36 153 497232 31861 62959776
Pericardial effusion 22.18 10.36 141 497244 29917 62961720
Developmental hip dysplasia 22.01 10.36 39 497346 1333 62990304
Placental disorder 21.91 10.36 41 497344 1463 62990174
Delirium 21.83 10.36 272 497113 50269 62941368
Body height below normal 21.83 10.36 51 497334 2132 62989505
Ketoacidosis 21.70 10.36 4 497381 4374 62987263
Rotator cuff repair 21.50 10.36 50 497335 2084 62989553
Mood altered 21.22 10.36 53 497332 14690 62976947
Multiple-drug resistance 21.22 10.36 7 497378 5163 62986474
Loose body in joint 21.21 10.36 37 497348 1249 62990388
Malignant melanoma 21.15 10.36 157 497228 11199 62980438
Respiration abnormal 21.08 10.36 12 497373 6405 62985232
Infusion site erythema 21 10.36 37 497348 11642 62979995
Bronchopulmonary aspergillosis 20.94 10.36 22 497363 8613 62983024
Vascular device infection 20.88 10.36 16 497369 7296 62984341
Coronary artery disease 20.87 10.36 158 497227 32219 62959418
Bundle branch block left 20.73 10.36 15 497370 7044 62984593
Synovial disorder 20.69 10.36 48 497337 1997 62989640
Rebound effect 20.66 10.36 5 497380 4521 62987116
Arthritis infective 20.66 10.36 103 497282 6375 62985262
Cyanosis 20.59 10.36 66 497319 16869 62974768
Purpura 20.53 10.36 36 497349 11349 62980288
Eating disorder 20.51 10.36 78 497307 18938 62972699
Epistaxis 20.49 10.36 424 496961 72301 62919336
Generalised oedema 20.41 10.36 60 497325 15758 62975879
Exostosis 20.40 10.36 222 497163 17640 62973997
Diabetes mellitus 20.30 10.36 311 497074 55499 62936138
Cardiac disorder 20.29 10.36 278 497107 50538 62941099
Pyrexia 20.21 10.36 3308 494077 467170 62524467
Myocarditis 20.16 10.36 31 497354 10294 62981343
Dermatitis atopic 20.16 10.36 28 497357 9696 62981941
Rheumatoid lung 19.97 10.36 71 497314 3777 62987860
Injection site bruising 19.88 10.36 449 496936 41461 62950176
Aspiration 19.85 10.36 34 497351 10817 62980820
Atrial septal defect 19.83 10.36 107 497278 6831 62984806
Hereditary angioedema 19.80 10.36 18 497367 7544 62984093
Pulmonary congestion 19.74 10.36 70 497315 17348 62974289
Febrile bone marrow aplasia 19.71 10.36 17 497368 7308 62984329
Foetal anticonvulsant syndrome 19.67 10.36 24 497361 581 62991056
Visual acuity reduced 19.58 10.36 96 497289 21730 62969907
Sexual dysfunction 19.54 10.36 5 497380 4354 62987283
Right ventricular failure 19.53 10.36 69 497316 17119 62974518
Affective disorder 19.48 10.36 12 497373 6134 62985503
Rash maculo-papular 19.46 10.36 158 497227 31738 62959899
Polyhydramnios 19.46 10.36 50 497335 2221 62989416
Head injury 19.46 10.36 130 497255 27266 62964371
Spinal stenosis 19.17 10.36 190 497195 14735 62976902
Hemiplegia 19.17 10.36 27 497358 9296 62982341
Presyncope 19.16 10.36 133 497252 27652 62963985
Delusion 19.07 10.36 41 497344 11976 62979661
Renal disorder 18.92 10.36 166 497219 32808 62958829
Sinus bradycardia 18.91 10.36 55 497330 14496 62977141
Granuloma skin 18.87 10.36 122 497263 8315 62983322
Pseudomonas infection 18.86 10.36 37 497348 11176 62980461
Nasal polyps 18.85 10.36 12 497373 6027 62985610
Skin papilloma 18.77 10.36 83 497302 4886 62986751
Pemphigoid 18.62 10.36 18 497367 7326 62984311
Clear cell renal cell carcinoma 18.61 10.36 38 497347 1447 62990190
Toxic epidermal necrolysis 18.61 10.36 119 497266 25215 62966422
Blood parathyroid hormone decreased 18.59 10.36 136 497249 9655 62981982
Product prescribing error 18.54 10.36 125 497260 26164 62965473
Injection site rash 18.45 10.36 227 497158 18582 62973055
Hyperprolactinaemia 18.42 10.36 4 497381 3896 62987741
Visual impairment 18.37 10.36 512 496873 83934 62907703
Acute myocardial infarction 18.31 10.36 162 497223 31962 62959675
Pathogen resistance 18.27 10.36 14 497371 6384 62985253
Schizoaffective disorder 18.22 10.36 3 497382 3559 62988078
Lupus vulgaris 18.20 10.36 94 497291 5900 62985737
Human antichimeric antibody positive 18.20 10.36 41 497344 1673 62989964
Fear of injection 18.17 10.36 107 497278 7057 62984580
Acute chest syndrome 18.17 10.36 27 497358 794 62990843
Malaise 18.14 10.36 2922 494463 413032 62578605
Aspergillus infection 18.12 10.36 22 497363 8071 62983566
Hypophosphataemia 18.11 10.36 39 497346 11387 62980250
Shock haemorrhagic 18.11 10.36 31 497354 9864 62981773
Tinnitus 18.04 10.36 185 497200 35443 62956194
Toxic encephalopathy 18.03 10.36 15 497370 6564 62985073
Gastrointestinal toxicity 17.97 10.36 113 497272 7628 62984009
Tumour marker increased 17.94 10.36 8 497377 4907 62986730
Bone marrow failure 17.91 10.36 145 497240 29145 62962492
Stillbirth 17.89 10.36 102 497283 6648 62984989
Dementia 17.84 10.36 81 497304 18713 62972924
Hypercholesterolaemia 17.81 10.36 250 497135 21084 62970553
Anger 17.75 10.36 45 497340 12411 62979226
Circulatory collapse 17.72 10.36 100 497285 21838 62969799
Renal tubular necrosis 17.65 10.36 42 497343 11836 62979801
Progressive multifocal leukoencephalopathy 17.62 10.36 48 497337 12923 62978714
Paranoia 17.59 10.36 41 497344 11638 62979999
Personality disorder 17.53 10.36 12 497373 5799 62985838
Antinuclear antibody positive 17.49 10.36 115 497270 7884 62983753
Pulmonary tuberculosis 17.48 10.36 76 497309 4441 62987196
Klebsiella infection 17.42 10.36 25 497360 8541 62983096
Anuria 17.39 10.36 46 497339 12505 62979132
Jaundice cholestatic 17.38 10.36 19 497366 7305 62984332
Cushingoid 17.36 10.36 120 497265 8365 62983272
Pulseless electrical activity 17.31 10.36 20 497365 7501 62984136
Polyuria 17.31 10.36 25 497360 8517 62983120
Congenital arterial malformation 17.30 10.36 17 497368 320 62991317
Treatment noncompliance 17.22 10.36 198 497187 37127 62954510
Hepatitis acute 17.22 10.36 28 497357 9092 62982545
Labelled drug-drug interaction medication error 17.16 10.36 51 497334 13348 62978289
Incorrect product administration duration 17.01 10.36 41 497344 11505 62980132
Salivary hypersecretion 16.99 10.36 21 497364 7645 62983992
Premature delivery 16.83 10.36 332 497053 29949 62961688
Device issue 16.81 10.36 113 497272 23668 62967969
Cardiotoxicity 16.80 10.36 25 497360 8413 62983224
Antibody test positive 16.75 10.36 53 497332 2654 62988983
Amylase increased 16.74 10.36 15 497370 6330 62985307
Pallor 16.62 10.36 156 497229 30412 62961225
Abnormal dreams 16.58 10.36 36 497349 10480 62981157
Troponin increased 16.50 10.36 34 497351 10087 62981550
Therapy change 16.50 10.36 14 497371 6067 62985570
Systemic inflammatory response syndrome 16.44 10.36 12 497373 5609 62986028
Tendonitis 16.43 10.36 230 497155 19385 62972252
Blood urea increased 16.41 10.36 130 497255 26249 62965388
Respiratory acidosis 16.40 10.36 17 497368 6698 62984939
Full blood count decreased 16.30 10.36 128 497257 25896 62965741
Myopathy 16.29 10.36 40 497345 11151 62980486
Middle insomnia 16.28 10.36 48 497337 12595 62979042
Oliguria 16.21 10.36 29 497356 9072 62982565
Gastroenteritis viral 16.04 10.36 268 497117 23432 62968205
Scleritis 16.00 10.36 73 497312 4355 62987282
Eosinophil count increased 15.95 10.36 39 497346 10889 62980748
Hyperthyroidism 15.94 10.36 60 497325 14613 62977024
Hallucinations, mixed 15.91 10.36 9 497376 4820 62986817
Peripheral sensory neuropathy 15.91 10.36 21 497364 7430 62984207
Epstein-Barr virus infection 15.88 10.36 24 497361 8026 62983611
Thrombosis 15.84 10.36 386 496999 64369 62927268
Plasma cell myeloma recurrent 15.79 10.36 3 497382 3210 62988427
Injection site pain 15.78 10.36 1201 496184 128599 62863038
Sciatica 15.75 10.36 366 497019 33958 62957679
Breast feeding 15.74 10.36 26 497359 839 62990798
Food allergy 15.63 10.36 42 497343 11359 62980278
Acute respiratory distress syndrome 15.57 10.36 114 497271 23420 62968217
Product complaint 15.52 10.36 50 497335 12759 62978878
Bundle branch block right 15.51 10.36 10 497375 4988 62986649
Ileus 15.49 10.36 61 497324 14664 62976973
Influenza like illness 15.36 10.36 402 496983 66422 62925215
Hepatitis B reactivation 15.27 10.36 3 497382 3134 62988503
Restless legs syndrome 15.22 10.36 84 497301 18447 62973190
Coordination abnormal 15.18 10.36 56 497329 13717 62977920
Subarachnoid haemorrhage 15.14 10.36 59 497326 14224 62977413
Pregnancy with contraceptive device 15.11 10.36 9 497376 4685 62986952
Hepatitis cholestatic 15.08 10.36 19 497366 6859 62984778
Ageusia 15.01 10.36 56 497329 13672 62977965
Neutropenic colitis 14.98 10.36 3 497382 3092 62988545
Sensitisation 14.96 10.36 4 497381 3382 62988255
Abdominal pain upper 14.92 10.36 1403 495982 205041 62786596
Tubulointerstitial nephritis 14.87 10.36 93 497292 19810 62971827
Throat tightness 14.86 10.36 124 497261 24763 62966874
Multiple drug therapy 14.85 10.36 5 497380 3641 62987996
Therapy partial responder 14.81 10.36 39 497346 10619 62981018
Transplant dysfunction 14.78 10.36 10 497375 4862 62986775
Ulcer 14.76 10.36 287 497098 25820 62965817
Somnambulism 14.75 10.36 13 497372 5530 62986107
Colitis microscopic 14.70 10.36 32 497353 9307 62982330
Haemodialysis 14.64 10.36 30 497355 8917 62982720
Fracture delayed union 14.61 10.36 47 497338 2375 62989262
Affect lability 14.60 10.36 42 497343 11109 62980528
Haematemesis 14.55 10.36 160 497225 30252 62961385
Laryngospasm 14.52 10.36 3 497382 3025 62988612
Extra dose administered 14.50 10.36 17 497368 6333 62985304
Postoperative wound infection 14.48 10.36 140 497245 10785 62980852
Macular degeneration 14.48 10.36 270 497115 24106 62967531
Dysuria 14.41 10.36 182 497203 33556 62958081
Breast cancer female 14.38 10.36 56 497329 13503 62978134
Renal injury 14.32 10.36 33 497352 9406 62982231
Polydipsia 14.32 10.36 5 497380 3559 62988078
Mouth ulceration 14.30 10.36 349 497036 32635 62959002
Body temperature increased 14.30 10.36 205 497180 36987 62954650
Short stature 14.29 10.36 22 497363 668 62990969
Bone lesion 14.24 10.36 15 497370 5866 62985771
Catheter management 14.24 10.36 3 497382 2984 62988653
Intracranial pressure increased 14.22 10.36 12 497373 5215 62986422
Crohn's disease 14.20 10.36 76 497309 4837 62986800
Panniculitis 14.17 10.36 144 497241 11241 62980396
Joint noise 14.12 10.36 70 497315 4322 62987315
Acute coronary syndrome 14.11 10.36 37 497348 10089 62981548
Gastroschisis 14.11 10.36 17 497368 406 62991231
Haemorrhage in pregnancy 14.10 10.36 40 497345 1885 62989752
Catheter site erythema 14.04 10.36 8 497377 4268 62987369
Lymphopenia 14.02 10.36 85 497300 18242 62973395
Bradykinesia 14.01 10.36 12 497373 5176 62986461
Graft versus host disease in gastrointestinal tract 14.00 10.36 4 497381 3237 62988400
Catheter site pain 13.99 10.36 10 497375 4725 62986912
Product substitution issue 13.98 10.36 71 497314 15925 62975712
Blood sodium decreased 13.96 10.36 122 497263 24130 62967507
Infusion site pruritus 13.95 10.36 16 497369 6019 62985618
Inadequate analgesia 13.94 10.36 3 497382 2940 62988697
Injection site warmth 13.89 10.36 181 497204 15014 62976623
Transaminases increased 13.85 10.36 168 497217 31199 62960438
Onychomycosis 13.84 10.36 108 497277 7824 62983813
Hyperbilirubinaemia 13.82 10.36 44 497341 11270 62980367
Fracture 13.82 10.36 223 497162 19361 62972276
Drug abuser 13.80 10.36 3 497382 2920 62988717
Embedded device 13.80 10.36 5 497380 3478 62988159
Intervertebral disc degeneration 13.80 10.36 186 497199 15546 62976091
Sleep disorder due to a general medical condition 13.80 10.36 49 497336 12139 62979498
Gestational hypertension 13.77 10.36 46 497339 2371 62989266
Motor dysfunction 13.75 10.36 41 497344 10720 62980917
Blood phosphorus decreased 13.69 10.36 9 497376 4444 62987193
Graft versus host disease in skin 13.68 10.36 3 497382 2902 62988735
Acute pulmonary oedema 13.65 10.36 27 497358 8131 62983506
Pulmonary alveolar haemorrhage 13.60 10.36 10 497375 4658 62986979
Ankle arthroplasty 13.60 10.36 38 497347 1775 62989862
Full blood count abnormal 13.58 10.36 171 497214 31546 62960091
Swelling face 13.51 10.36 386 496999 63089 62928548
Mental impairment 13.42 10.36 61 497324 14090 62977547
Atrial flutter 13.40 10.36 36 497349 9736 62981901
Dactylitis 13.39 10.36 48 497337 2564 62989073
Embolism 13.37 10.36 26 497359 7880 62983757
Exomphalos 13.32 10.36 19 497366 538 62991099
Talipes 13.29 10.36 34 497351 1506 62990131
Lung transplant 13.26 10.36 4 497381 3124 62988513
Product preparation error 13.18 10.36 17 497368 6075 62985562
Breast cancer metastatic 13.15 10.36 49 497336 11969 62979668
Dermatitis exfoliative 13.13 10.36 14 497371 5445 62986192
Speech disorder developmental 13.13 10.36 21 497364 659 62990978
Hepatic cytolysis 13.12 10.36 69 497316 15338 62976299
Drug screen positive 13.10 10.36 6 497379 3623 62988014
Flatulence 13.09 10.36 192 497193 34510 62957127
Ear infection 13.06 10.36 392 496993 37821 62953816
Autism spectrum disorder 13.03 10.36 24 497361 846 62990791
Bacteraemia 12.99 10.36 81 497304 17267 62974370
Oligoarthritis 12.95 10.36 19 497366 552 62991085
Pulmonary toxicity 12.95 10.36 122 497263 9333 62982304
Madarosis 12.95 10.36 4 497381 3077 62988560
Carotid artery thrombosis 12.93 10.36 3 497382 2791 62988846
Hypoventilation 12.83 10.36 11 497374 4743 62986894
Nystagmus 12.80 10.36 18 497367 6202 62985435
Post procedural haemorrhage 12.78 10.36 27 497358 7937 62983700
Injury 12.77 10.36 699 496686 72548 62919089
Hypertransaminasaemia 12.75 10.36 20 497365 6589 62985048
Hypertelorism 12.75 10.36 17 497368 451 62991186
Nasal obstruction 12.71 10.36 36 497349 1695 62989942
Congenital cerebral cyst 12.68 10.36 13 497372 258 62991379
Catatonia 12.53 10.36 10 497375 4467 62987170
Atrial tachycardia 12.47 10.36 9 497376 4231 62987406
Facial paralysis 12.46 10.36 62 497323 13979 62977658
Heart rate increased 12.45 10.36 607 496778 93631 62898006
Product administered to patient of inappropriate age 12.44 10.36 5 497380 3263 62988374
Trigeminal neuralgia 12.42 10.36 6 497379 3513 62988124
Wrong product administered 12.42 10.36 18 497367 6123 62985514
Ataxia 12.41 10.36 69 497316 15126 62976511
Tongue disorder 12.31 10.36 132 497253 10448 62981189
Pneumonia 12.29 10.36 3287 494098 453480 62538157
Nail injury 12.25 10.36 20 497365 639 62990998
End stage renal disease 12.22 10.36 21 497364 6672 62984965
Nephropathy toxic 12.20 10.36 36 497349 9443 62982194
Lymphatic fistula 12.17 10.36 22 497363 764 62990873
Hepatic necrosis 12.17 10.36 16 497369 5671 62985966
Neonatal respiratory distress syndrome 12.15 10.36 49 497336 2769 62988868
Impaired gastric emptying 12.06 10.36 41 497344 10291 62981346
Hypernatraemia 12.04 10.36 26 497359 7583 62984054
Foetal distress syndrome 12.03 10.36 30 497355 1308 62990329
Human anti-human antibody test 12.01 10.36 16 497369 424 62991213
Metastases to lymph nodes 12.00 10.36 29 497356 8129 62983508
Cytomegalovirus viraemia 11.98 10.36 16 497369 5633 62986004
Oropharyngeal pain 11.94 10.36 877 496508 93610 62898027
Injection site haematoma 11.91 10.36 93 497292 6739 62984898
Brain natriuretic peptide increased 11.85 10.36 14 497371 5199 62986438
Cervical incompetence 11.84 10.36 19 497366 598 62991039
Skin cancer 11.83 10.36 140 497245 11355 62980282
Pelvic pain 11.82 10.36 60 497325 13459 62978178
Pulmonary haemorrhage 11.81 10.36 24 497361 7157 62984480
Diabetes insipidus 11.79 10.36 3 497382 2622 62989015
Hypocalcaemia 11.78 10.36 176 497209 31537 62960100
Pneumonia viral 11.78 10.36 28 497357 7894 62983743
Metabolic encephalopathy 11.77 10.36 17 497368 5792 62985845
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.77 10.36 4 497381 2895 62988742
Lipase increased 11.75 10.36 39 497346 9861 62981776
Product physical issue 11.73 10.36 13 497372 4967 62986670
Blood pressure inadequately controlled 11.72 10.36 13 497372 4965 62986672
Blood loss anaemia 11.72 10.36 34 497351 8967 62982670
Learning disorder 11.68 10.36 20 497365 665 62990972
Erythema 11.64 10.36 1202 496183 174549 62817088
Eye pruritus 11.62 10.36 92 497293 18579 62973058
Hyperthermia 11.62 10.36 35 497350 9121 62982516
Incoherent 11.61 10.36 11 497374 4519 62987118
Hyperuricaemia 11.60 10.36 15 497370 5355 62986282
Cholestasis of pregnancy 11.58 10.36 28 497357 1197 62990440
Abortion incomplete 11.58 10.36 5 497380 3126 62988511
Temperature intolerance 11.57 10.36 34 497351 8930 62982707
Laboratory test abnormal 11.56 10.36 145 497240 26767 62964870
Epilepsy 11.56 10.36 146 497239 26919 62964718
Glomerular filtration rate decreased 11.55 10.36 60 497325 13381 62978256
Induced labour 11.53 10.36 24 497361 927 62990710
Occult blood 11.52 10.36 29 497356 1272 62990365
Bone density increased 11.46 10.36 21 497364 737 62990900
Hypoglycaemic coma 11.46 10.36 3 497382 2572 62989065
Chronic obstructive pulmonary disease 11.45 10.36 389 496996 62297 62929340
Poor venous access 11.45 10.36 171 497214 14614 62977023
Skin toxicity 11.44 10.36 12 497373 4702 62986935
Cleft lip and palate 11.44 10.36 19 497366 616 62991021
Electrocardiogram QRS complex prolonged 11.43 10.36 18 497367 5920 62985717
Foetal death 11.42 10.36 134 497251 10846 62980791
Endophthalmitis 11.40 10.36 7 497378 3585 62988052
Blood lactic acid increased 11.39 10.36 24 497361 7062 62984575
Lacrimation increased 11.34 10.36 105 497280 20526 62971111
Coronary arterial stent insertion 11.32 10.36 4 497381 2825 62988812
Foot operation 11.29 10.36 96 497289 7135 62984502
X-ray abnormal 11.29 10.36 105 497280 8005 62983632
Seronegative arthritis 11.28 10.36 61 497324 3898 62987739
Syndactyly 11.27 10.36 16 497369 451 62991186
Ligament rupture 11.27 10.36 55 497330 3375 62988262
Blood iron increased 11.25 10.36 32 497353 1510 62990127
Exercise tolerance decreased 11.22 10.36 16 497369 5481 62986156
Pleuritic pain 11.20 10.36 104 497281 7925 62983712
Staphylococcal infection 11.19 10.36 242 497143 41014 62950623
Autoimmune disorder 11.17 10.36 193 497192 16984 62974653
Wound infection pseudomonas 11.13 10.36 29 497356 1299 62990338
Mucosal inflammation 11.13 10.36 281 497104 46647 62944990
Femoral hernia incarcerated 11.11 10.36 22 497363 819 62990818
Forceps delivery 11.11 10.36 11 497374 209 62991428
Post-traumatic stress disorder 11.01 10.36 15 497370 5236 62986401
Joint warmth 10.99 10.36 31 497354 1456 62990181
Neutrophilia 10.94 10.36 11 497374 4395 62987242
Threatened labour 10.88 10.36 22 497363 832 62990805
Thirst 10.81 10.36 65 497320 13976 62977661
Cold sweat 10.80 10.36 53 497332 11994 62979643
Ventricular extrasystoles 10.72 10.36 51 497334 11636 62980001
Cartilage injury 10.71 10.36 37 497348 1940 62989697
Electrolyte imbalance 10.68 10.36 103 497282 19973 62971664
Neuralgia 10.65 10.36 141 497244 25785 62965852
Anterior chamber cleavage syndrome 10.63 10.36 10 497375 178 62991459
Joint lock 10.62 10.36 41 497344 2270 62989367
Ileus paralytic 10.59 10.36 12 497373 4539 62987098
Sickle cell anaemia 10.57 10.36 17 497368 536 62991101
Activated partial thromboplastin time prolonged 10.54 10.36 24 497361 6869 62984768
Iritis 10.49 10.36 51 497334 3124 62988513
Rectal haemorrhage 10.48 10.36 298 497087 48732 62942905
Dialysis 10.47 10.36 44 497341 10383 62981254
Prothrombin time prolonged 10.46 10.36 39 497346 9525 62982112
Onychomadesis 10.46 10.36 80 497305 5760 62985877
Tendon disorder 10.44 10.36 80 497305 5763 62985874
Oral pain 10.40 10.36 158 497227 28236 62963401
Colorectal cancer 10.38 10.36 8 497377 3637 62988000

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 613.34 10.28 823 162686 37415 34756007
Drug abuse 328.53 10.28 39 163470 99057 34694365
Foetal exposure during pregnancy 315.68 10.28 607 162902 37494 34755928
Toxicity to various agents 271.27 10.28 323 163186 200039 34593383
Arthralgia 252.37 10.28 1506 162003 168535 34624887
Completed suicide 236.35 10.28 82 163427 98086 34695336
Psoriatic arthropathy 200.23 10.28 344 163165 19454 34773968
Sickle cell anaemia with crisis 154.94 10.28 138 163371 3915 34789507
Joint swelling 144.39 10.28 609 162900 59281 34734141
Dysmorphism 140.00 10.28 117 163392 3039 34790383
Drug interaction 136.90 10.28 568 162941 225378 34568044
Musculoskeletal stiffness 108.87 10.28 470 163039 46210 34747212
Premature baby 108.83 10.28 266 163243 19367 34774055
Intentional overdose 97.52 10.28 41 163468 43633 34749789
Synovitis 94.97 10.28 206 163303 13860 34779562
Blood pressure fluctuation 94.17 10.28 296 163213 24953 34768469
Psoriasis 93.76 10.28 395 163114 38417 34755005
Enthesopathy 92.41 10.28 111 163398 4502 34788920
Acute kidney injury 86.19 10.28 962 162547 304026 34489396
Pain 85.87 10.28 1389 162120 203286 34590136
Tenosynovitis 85.12 10.28 106 163403 4464 34788958
Exposure during pregnancy 84.81 10.28 151 163358 8783 34784639
C-reactive protein abnormal 81.13 10.28 146 163363 8564 34784858
Speech disorder developmental 78.38 10.28 72 163437 2128 34791294
Death 78.36 10.28 1351 162158 396698 34396724
Blood pressure systolic increased 69.59 10.28 251 163258 22701 34770721
Arthropathy 68.24 10.28 278 163231 26629 34766793
Neonatal respiratory distress syndrome 67.93 10.28 89 163420 3945 34789477
Maternal exposure during pregnancy 65.61 10.28 97 163412 4821 34788601
Foetal anticonvulsant syndrome 65.45 10.28 50 163459 1137 34792285
Atrial septal defect 62.68 10.28 119 163390 7273 34786149
Hypospadias 62.45 10.28 76 163433 3125 34790297
Overdose 62.05 10.28 218 163291 90841 34702581
Alanine aminotransferase abnormal 61.87 10.28 92 163417 4596 34788826
Coma 61.25 10.28 74 163435 45604 34747818
Arthritis 60.76 10.28 299 163210 31047 34762375
Suicide attempt 60.71 10.28 56 163453 39060 34754362
Low birth weight baby 60.64 10.28 122 163387 7783 34785639
Product use in unapproved indication 60.55 10.28 313 163196 117186 34676236
Cryptorchism 59.84 10.28 60 163449 1981 34791441
Serotonin syndrome 58.75 10.28 11 163498 19922 34773500
Disease progression 57.91 10.28 284 163225 107793 34685629
Maternal drugs affecting foetus 56.97 10.28 81 163428 3884 34789538
Nasopharyngitis 56.33 10.28 537 162972 69431 34723991
Rhabdomyolysis 55.81 10.28 150 163359 68013 34725409
Autism spectrum disorder 55.70 10.28 61 163448 2235 34791187
Learning disorder 53.76 10.28 43 163466 1048 34792374
Small for dates baby 51.73 10.28 77 163432 3850 34789572
Tongue disorder 51.66 10.28 91 163418 5248 34788174
Hypoglycaemia neonatal 50.51 10.28 53 163456 1848 34791574
Palmar-plantar erythrodysaesthesia syndrome 50.07 10.28 9 163500 16786 34776636
Blood pressure systolic abnormal 50.00 10.28 76 163433 3872 34789550
Rheumatoid nodule 49.60 10.28 65 163444 2882 34790540
Drug intolerance 48.34 10.28 458 163051 59112 34734310
Drug reaction with eosinophilia and systemic symptoms 48.07 10.28 50 163459 32962 34760460
Hepatic function abnormal 47.59 10.28 84 163425 44279 34749143
Bradycardia 46.53 10.28 188 163321 75230 34718192
Maternal exposure during breast feeding 46.47 10.28 46 163463 1495 34791927
Ventricular septal defect 46.46 10.28 74 163435 3927 34789495
Lower respiratory tract infection 45.96 10.28 279 163230 31358 34762064
Infusion related reaction 45.61 10.28 413 163096 52644 34740778
Blood pressure diastolic abnormal 45.17 10.28 81 163428 4737 34788685
Drug dependence 44.78 10.28 29 163480 24188 34769234
Syndactyly 44.10 10.28 35 163474 843 34792579
Drug resistance 44.06 10.28 34 163475 25893 34767529
Suicidal ideation 43.75 10.28 76 163433 40312 34753110
Heart rate decreased 43.63 10.28 276 163233 31469 34761953
Pain in extremity 43.43 10.28 832 162677 125681 34667741
Osteoarthritis 42.96 10.28 201 163308 20441 34772981
Hand deformity 42.03 10.28 68 163441 3657 34789765
Blood pressure diastolic decreased 41.93 10.28 115 163394 8979 34784443
Pulmonary fibrosis 41.93 10.28 184 163325 18212 34775210
Developmental delay 41.81 10.28 58 163451 2717 34790705
Pancytopenia 41.37 10.28 650 162859 94507 34698915
Foot deformity 40.92 10.28 75 163434 4462 34788960
Joint effusion 40.86 10.28 81 163428 5112 34788310
C-reactive protein increased 40.02 10.28 408 163101 53690 34739732
Blood pressure increased 39.90 10.28 606 162903 87496 34705926
Angioedema 39.87 10.28 71 163438 37303 34756119
Tendonitis 39.60 10.28 113 163396 9027 34784395
Talipes 38.07 10.28 46 163463 1877 34791545
Exposure via breast milk 38.04 10.28 47 163462 1963 34791459
Grip strength decreased 37.33 10.28 59 163450 3110 34790312
Renal failure 36.66 10.28 412 163097 130145 34663277
Cytomegalovirus infection 36.47 10.28 41 163468 26094 34767328
Joint laxity 35.96 10.28 23 163486 389 34793033
Basal cell carcinoma 34.92 10.28 183 163326 19475 34773947
Psychotic disorder 34.52 10.28 38 163471 24414 34769008
Febrile neutropenia 33.80 10.28 444 163065 136405 34657017
Peripheral swelling 33.70 10.28 524 162985 76017 34717405
Lactic acidosis 33.66 10.28 70 163439 34702 34758720
Foetal growth restriction 33.34 10.28 65 163444 4052 34789370
Intellectual disability 33.25 10.28 36 163473 1302 34792120
Knee arthroplasty 33.20 10.28 93 163416 7351 34786071
Red blood cell sedimentation rate increased 32.86 10.28 106 163403 9056 34784366
Congenital hand malformation 32.67 10.28 25 163484 570 34792852
Plagiocephaly 32.25 10.28 24 163485 524 34792898
Respiratory arrest 32.01 10.28 51 163458 27992 34765430
Jaundice neonatal 31.34 10.28 35 163474 1311 34792111
Polyarthritis 31.23 10.28 67 163442 4473 34788949
Inflammation 31.17 10.28 233 163276 28062 34765360
Body temperature decreased 30.95 10.28 132 163377 12902 34780520
Hypermobility syndrome 30.93 10.28 20 163489 345 34793077
Caesarean section 30.78 10.28 44 163465 2120 34791302
Delirium 30.16 10.28 105 163404 43886 34749536
Immune reconstitution inflammatory syndrome 30.13 10.28 3 163506 8756 34784666
Cardiac failure 30.13 10.28 277 163232 90971 34702451
Drug withdrawal syndrome 30.06 10.28 29 163480 19805 34773617
Poisoning 29.76 10.28 10 163499 12216 34781206
Anal fistula 29.75 10.28 73 163436 5326 34788096
Finger deformity 29.64 10.28 36 163473 1477 34791945
Language disorder 29.38 10.28 44 163465 2212 34791210
Acute chest syndrome 29.33 10.28 27 163482 800 34792622
Agitation 28.92 10.28 154 163355 57245 34736177
Astigmatism 28.11 10.28 30 163479 1067 34792355
Cardiac arrest 27.95 10.28 301 163208 95858 34697564
Hyperglycaemia 27.90 10.28 93 163416 39387 34754035
Haemoglobin decreased 27.57 10.28 750 162759 120022 34673400
Dysgraphia 27.52 10.28 43 163466 2244 34791178
Large for dates baby 26.94 10.28 27 163482 891 34792531
Altered state of consciousness 26.73 10.28 41 163468 22852 34770570
Selective eating disorder 26.55 10.28 37 163472 1741 34791681
Hydrops foetalis 26.37 10.28 26 163483 841 34792581
Hypotonia neonatal 26.34 10.28 32 163477 1313 34792109
Tuberculosis 26.16 10.28 94 163415 8483 34784939
Diaphragmatic disorder 26.06 10.28 31 163478 1244 34792178
Blood pressure diastolic increased 25.65 10.28 66 163443 4959 34788463
Drug withdrawal syndrome neonatal 25.57 10.28 54 163455 3565 34789857
Intentional product misuse 25.49 10.28 118 163391 45493 34747929
Ultrasound antenatal screen 25.47 10.28 21 163488 535 34792887
Wound 25.47 10.28 137 163372 14727 34778695
Ankylosing spondylitis 24.98 10.28 70 163439 5534 34787888
Urticaria 24.87 10.28 180 163329 62197 34731225
Hyperbilirubinaemia neonatal 24.81 10.28 24 163485 758 34792664
Acute hepatic failure 24.50 10.28 18 163491 14056 34779366
Weight decreased 24.48 10.28 1033 162476 175268 34618154
Depressed level of consciousness 24.44 10.28 110 163399 42731 34750691
Pathogen resistance 24.43 10.28 7 163502 9475 34783947
Nasal disorder 24.25 10.28 37 163472 1891 34791531
Sedation 24.17 10.28 38 163471 20968 34772454
Musculoskeletal pain 24.08 10.28 242 163267 31721 34761701
Motor developmental delay 24.06 10.28 22 163487 646 34792776
Knee deformity 24.06 10.28 22 163487 646 34792776
Radiation inflammation 23.63 10.28 25 163484 880 34792542
Hypoglycaemia 23.60 10.28 154 163355 54486 34738936
Trisomy 18 23.22 10.28 23 163486 748 34792674
Dyspraxia 23.20 10.28 18 163491 419 34793003
Lung neoplasm malignant 23.13 10.28 150 163359 17245 34776177
Neuroleptic malignant syndrome 23.05 10.28 30 163479 17904 34775518
Substance abuse 22.98 10.28 4 163505 7637 34785785
Colitis ulcerative 22.92 10.28 144 163365 16376 34777046
Strabismus 22.89 10.28 34 163475 1697 34791725
Therapeutic product effect decreased 22.87 10.28 256 163253 34487 34758935
Serum ferritin increased 22.86 10.28 72 163437 6074 34787348
Anal fissure 22.58 10.28 57 163452 4233 34789189
Constipation 22.46 10.28 479 163030 136503 34656919
Toxic epidermal necrolysis 22.30 10.28 42 163467 21604 34771818
Blood creatine phosphokinase increased 22.24 10.28 121 163388 44736 34748686
Intentional self-injury 22.22 10.28 19 163490 13752 34779670
Loss of personal independence in daily activities 22.08 10.28 245 163264 32934 34760488
Hydrocele 22.06 10.28 37 163472 2050 34791372
Skin cancer 21.96 10.28 101 163408 10196 34783226
Foetal disorder 21.89 10.28 23 163486 803 34792619
Localised infection 21.79 10.28 149 163360 17438 34775984
Cleft lip and palate 21.73 10.28 24 163485 888 34792534
Respiratory disorder neonatal 21.53 10.28 32 163477 1598 34791824
Vitamin D deficiency 21.52 10.28 74 163435 6534 34786888
Poor venous access 21.41 10.28 63 163446 5120 34788302
Joint range of motion decreased 21.35 10.28 79 163430 7233 34786189
Red blood cell sedimentation rate 21.24 10.28 27 163482 1161 34792261
Renal impairment 21.06 10.28 313 163196 94200 34699222
Oropharyngeal pain 20.93 10.28 256 163253 35229 34758193
Blood parathyroid hormone decreased 20.92 10.28 30 163479 1450 34791972
Congenital foot malformation 20.89 10.28 17 163492 425 34792997
Shock 20.70 10.28 52 163457 24127 34769295
No adverse event 20.67 10.28 48 163461 22879 34770543
Joint stiffness 20.55 10.28 103 163406 10770 34782652
Juvenile idiopathic arthritis 20.55 10.28 34 163475 1863 34791559
Dyslexia 20.49 10.28 15 163494 319 34793103
Otitis media 20.46 10.28 43 163466 2829 34790593
Cleft lip 20.37 10.28 15 163494 322 34793100
Infection 20.29 10.28 563 162946 90352 34703070
Somnolence 20.18 10.28 382 163127 110734 34682688
Rash maculo-papular 20.11 10.28 67 163442 28384 34765038
Hepatic failure 20.09 10.28 88 163421 34443 34758979
Arthritis bacterial 20.09 10.28 61 163448 5045 34788377
Hallucination 19.86 10.28 150 163359 51348 34742074
Agitation neonatal 19.74 10.28 25 163484 1071 34792351
Granuloma skin 19.67 10.28 27 163482 1252 34792170
Arthritis infective 19.66 10.28 47 163462 3372 34790050
Behaviour disorder 19.64 10.28 59 163450 4851 34788571
Infective pulmonary exacerbation of cystic fibrosis 19.52 10.28 4 163505 6797 34786625
Oxygen saturation decreased 19.49 10.28 357 163152 53461 34739961
Umbilical hernia 19.47 10.28 57 163452 4620 34788802
Diabetic ketoacidosis 19.46 10.28 34 163475 17998 34775424
Medical device implantation 19.46 10.28 19 163490 607 34792815
Neurotoxicity 19.40 10.28 34 163475 17976 34775446
Multiple congenital abnormalities 19.21 10.28 18 163491 546 34792876
Crohn's disease 19.18 10.28 44 163465 3073 34790349
Gastrointestinal infection 18.94 10.28 65 163444 5733 34787689
Haematochezia 18.76 10.28 314 163195 46220 34747202
Microcephaly 18.73 10.28 21 163488 790 34792632
Bronchiolitis 18.63 10.28 44 163465 3132 34790290
Malignant melanoma 18.49 10.28 81 163428 8009 34785413
General physical health deterioration 18.34 10.28 754 162755 127515 34665907
Immunodeficiency 18.28 10.28 62 163447 5436 34787986
Lacrimal disorder 18.19 10.28 14 163495 322 34793100
Anaphylactic shock 18.18 10.28 29 163480 15912 34777510
Joint ankylosis 18.15 10.28 29 163480 1543 34791879
Weight decrease neonatal 18.08 10.28 14 163495 325 34793097
Congenital bladder anomaly 18.02 10.28 13 163496 270 34793152
Cerebral haemorrhage 18.01 10.28 93 163416 34844 34758578
Renal aplasia 17.98 10.28 20 163489 746 34792676
Haematocrit decreased 17.97 10.28 230 163279 31986 34761436
C-reactive protein decreased 17.93 10.28 33 163476 1969 34791453
Congenital anomaly 17.90 10.28 27 163482 1366 34792056
Electrocardiogram QT prolonged 17.89 10.28 115 163394 40837 34752585
Attention deficit hyperactivity disorder 17.87 10.28 38 163471 2521 34790901
Spinal disorder 17.87 10.28 52 163457 4200 34789222
Malignant neoplasm progression 17.79 10.28 297 163212 87749 34705673
Bone cyst 17.77 10.28 29 163480 1571 34791851
Limb reduction defect 17.70 10.28 13 163496 278 34793144
Pectus excavatum 17.46 10.28 12 163497 230 34793192
Ankyloglossia congenital 17.46 10.28 13 163496 284 34793138
Drug ineffective for unapproved indication 17.35 10.28 55 163454 23660 34769762
Anti-cyclic citrullinated peptide antibody positive 17.30 10.28 31 163478 1812 34791610
Post procedural infection 17.25 10.28 56 163453 4800 34788622
Respiratory depression 17.20 10.28 31 163478 16214 34777208
Patent ductus arteriosus 17.07 10.28 44 163465 3310 34790112
Venoocclusive liver disease 16.96 10.28 8 163501 7958 34785464
Nodule 16.92 10.28 70 163439 6749 34786673
Respiratory rate increased 16.82 10.28 91 163418 9803 34783619
Aggression 16.73 10.28 110 163399 38854 34754568
Scoliosis 16.72 10.28 39 163470 2754 34790668
Septic arthritis staphylococcal 16.68 10.28 16 163493 500 34792922
Haemangioma congenital 16.63 10.28 16 163493 502 34792920
Ear disorder 16.60 10.28 29 163480 1661 34791761
Skin injury 16.58 10.28 35 163474 2310 34791112
Respiratory failure 16.55 10.28 384 163125 108188 34685234
Polydactyly 16.29 10.28 24 163485 1189 34792233
Arthrodesis 16.22 10.28 15 163494 447 34792975
Unresponsive to stimuli 16.20 10.28 70 163439 27499 34765923
Abortion spontaneous 16.05 10.28 14 163495 386 34793036
Ear infection 15.99 10.28 92 163417 10139 34783283
Condition aggravated 15.94 10.28 1073 162436 191123 34602299
Fistula discharge 15.90 10.28 20 163489 851 34792571
Hepatic enzyme increased 15.86 10.28 264 163245 38816 34754606
Wrong technique in product usage process 15.75 10.28 101 163408 35885 34757537
Vitamin B12 deficiency 15.71 10.28 48 163461 3983 34789439
Heart rate irregular 15.65 10.28 127 163382 15680 34777742
Bradycardia neonatal 15.61 10.28 21 163488 955 34792467
Metabolic acidosis 15.55 10.28 130 163379 43550 34749872
Latent tuberculosis 15.54 10.28 25 163484 1338 34792084
Synovial cyst 15.45 10.28 34 163475 2310 34791112
Arnold-Chiari malformation 15.45 10.28 13 163496 341 34793081
Haemangioma 15.42 10.28 30 163479 1867 34791555
Ventricular tachycardia 15.30 10.28 68 163441 26511 34766911
Oesophageal fibrosis 15.29 10.28 10 163499 176 34793246
Red blood cell sedimentation rate abnormal 15.19 10.28 44 163465 3545 34789877
Foetal distress syndrome 15.11 10.28 22 163487 1078 34792344
Hypertelorism 15.06 10.28 16 163493 566 34792856
Tooth malformation 15.05 10.28 10 163499 181 34793241
Anal inflammation 15.03 10.28 24 163485 1276 34792146
Neck mass 14.97 10.28 27 163482 1586 34791836
Abnormal behaviour 14.91 10.28 63 163446 24906 34768516
Respiratory tract infection viral 14.91 10.28 35 163474 2482 34790940
Hypermetropia 14.87 10.28 15 163494 499 34792923
Back disorder 14.75 10.28 66 163443 6585 34786837
Psychomotor retardation 14.73 10.28 44 163465 3606 34789816
Mobility decreased 14.71 10.28 210 163299 29918 34763504
Foetal heart rate deceleration abnormality 14.70 10.28 15 163494 506 34792916
Tachycardia 14.60 10.28 294 163215 84478 34708944
Akathisia 14.60 10.28 10 163499 8099 34785323
Multiple organ dysfunction syndrome 14.59 10.28 261 163248 76305 34717117
Pharyngeal disorder 14.58 10.28 18 163491 751 34792671
Developmental coordination disorder 14.58 10.28 10 163499 191 34793231
Maternal exposure timing unspecified 14.56 10.28 13 163496 370 34793052
Autoscopy 14.55 10.28 11 163498 246 34793176
Cellulitis 14.48 10.28 337 163172 52614 34740808
Hypertriglyceridaemia 14.45 10.28 11 163498 8437 34784985
Upper respiratory tract infection 14.41 10.28 226 163283 32833 34760589
Panniculitis 14.38 10.28 30 163479 1964 34791458
Off label use 14.37 10.28 1731 161778 417793 34375629
Product quality issue 14.30 10.28 37 163472 16998 34776424
Aspergillus infection 14.26 10.28 22 163487 12232 34781190
Hepatitis E antibody positive 14.18 10.28 11 163498 256 34793166
Maternal exposure before pregnancy 14.18 10.28 18 163491 773 34792649
Inguinal hernia 14.17 10.28 72 163437 7569 34785853
Osteonecrosis of jaw 14.16 10.28 40 163469 17849 34775573
Neutropenia neonatal 14.04 10.28 17 163492 695 34792727
Sexual dysfunction 13.93 10.28 6 163503 6297 34787125
Blood test abnormal 13.86 10.28 67 163442 6904 34786518
Weight increased 13.78 10.28 549 162960 92484 34700938
Educational problem 13.75 10.28 15 163494 547 34792875
Irritability 13.72 10.28 64 163445 24626 34768796
Drug level increased 13.67 10.28 55 163454 22041 34771381
Pleuritic pain 13.65 10.28 42 163467 3499 34789923
Pyrexia 13.50 10.28 1358 162151 331655 34461767
SARS-CoV-2 test negative 13.44 10.28 20 163489 1000 34792422
Vascular insufficiency 13.42 10.28 12 163497 342 34793080
Adenovirus infection 13.33 10.28 4 163505 5253 34788169
Hernia pain 13.28 10.28 11 163498 282 34793140
Colorectal cancer 13.26 10.28 3 163506 4758 34788664
Blood insulin increased 13.25 10.28 12 163497 348 34793074
Hypotension 13.24 10.28 876 162633 220773 34572649
Cystitis haemorrhagic 13.21 10.28 5 163504 5674 34787748
Suspected suicide 13.20 10.28 3 163506 4745 34788677
Rheumatoid lung 13.17 10.28 19 163490 923 34792499
Anal atresia 13.12 10.28 11 163498 287 34793135
Perineal rash 13.11 10.28 3 163506 0 34793422
Proteinuria 13.11 10.28 44 163465 18598 34774824
Hepatitis E virus test positive 13.09 10.28 11 163498 288 34793134
Spina bifida 13.00 10.28 12 163497 357 34793065
Withdrawal syndrome 12.98 10.28 24 163485 12431 34780991
Fine motor skill dysfunction 12.86 10.28 27 163482 1775 34791647
Haemolysis 12.79 10.28 73 163436 8021 34785401
Pharyngitis 12.79 10.28 72 163437 7872 34785550
Obsessive-compulsive disorder 12.78 10.28 5 163504 5559 34787863
Pleural fibrosis 12.68 10.28 23 163486 1357 34792065
Ear malformation 12.65 10.28 11 163498 302 34793120
Cholestasis 12.64 10.28 74 163435 26874 34766548
Nail bed bleeding 12.61 10.28 12 163497 371 34793051
Cardiac murmur 12.60 10.28 71 163438 7766 34785656
Nail pitting 12.59 10.28 11 163498 304 34793118
Neuropathy peripheral 12.54 10.28 295 163214 82968 34710454
Mouth ulceration 12.51 10.28 97 163412 11813 34781609
Low set ears 12.33 10.28 13 163496 456 34792966
Cytokine release syndrome 12.30 10.28 60 163449 22817 34770605
Gangrene neonatal 12.27 10.28 9 163500 192 34793230
Tooth injury 12.26 10.28 21 163488 1184 34792238
Injection site haemorrhage 12.24 10.28 83 163426 9685 34783737
Palindromic rheumatism 12.23 10.28 9 163500 193 34793229
Vitamin B complex deficiency 12.12 10.28 12 163497 390 34793032
Congenital hydronephrosis 12.08 10.28 16 163493 717 34792705
Pulmonary pain 12.02 10.28 21 163488 1203 34792219
Gross motor delay 11.98 10.28 11 163498 325 34793097
Nephrolithiasis 11.97 10.28 204 163305 30129 34763293
Scrotal infection 11.93 10.28 15 163494 638 34792784
Paranoia 11.92 10.28 24 163485 12044 34781378
Excessive cerumen production 11.92 10.28 11 163498 327 34793095
Steatorrhoea 11.91 10.28 16 163493 727 34792695
BK virus infection 11.85 10.28 6 163503 5732 34787690
Myopia 11.82 10.28 20 163489 1116 34792306
Osteolysis 11.82 10.28 37 163472 3111 34790311
Cholelithiasis 11.80 10.28 151 163358 20997 34772425
Neonatal infection 11.75 10.28 12 163497 405 34793017
Acute graft versus host disease 11.73 10.28 8 163501 6495 34786927
Fistula 11.69 10.28 63 163446 6777 34786645
Pulmonary artery stenosis congenital 11.62 10.28 13 163496 488 34792934
Myoclonus 11.60 10.28 33 163476 14692 34778730
Neonatal seizure 11.55 10.28 13 163496 491 34792931
Congenital genital malformation 11.52 10.28 8 163501 156 34793266
Hepatic encephalopathy 11.50 10.28 33 163476 14652 34778770
Melaena 11.41 10.28 108 163401 35272 34758150
Bone erosion 11.40 10.28 43 163466 3972 34789450
Cerebral ventricle dilatation 11.40 10.28 18 163491 948 34792474
Pulmonary alveolar haemorrhage 11.36 10.28 11 163498 7501 34785921
Meningeal disorder 11.36 10.28 11 163498 348 34793074
Confusional state 11.28 10.28 555 162954 143605 34649817
Visuospatial deficit 11.28 10.28 7 163502 112 34793310
Hyperammonaemia 11.27 10.28 8 163501 6359 34787063
Hypokalaemia 11.23 10.28 198 163311 58016 34735406
End stage renal disease 11.20 10.28 15 163494 8846 34784576
Blood phosphorus increased 11.15 10.28 68 163441 7653 34785769
Gastroschisis 11.14 10.28 8 163501 165 34793257
Skin abrasion 11.12 10.28 64 163445 7055 34786367
Mesothelioma 11.10 10.28 12 163497 433 34792989
Non-Hodgkin's lymphoma 11.06 10.28 23 163486 1502 34791920
Peripheral artery thrombosis 11.03 10.28 30 163479 2330 34791092
Contraindicated product administered 11.00 10.28 151 163358 21330 34772092
Cardio-respiratory arrest 10.98 10.28 187 163322 55086 34738336
Hepatocellular injury 10.96 10.28 60 163449 22151 34771271
Decreased appetite 10.90 10.28 652 162857 165740 34627682
Nephropathy toxic 10.83 10.28 27 163482 12561 34780861
Hypoxia 10.75 10.28 187 163322 54908 34738514
Foetal hypokinesia 10.73 10.28 11 163498 373 34793049
Hallucination, auditory 10.70 10.28 25 163484 11892 34781530
Device leakage 10.70 10.28 9 163500 6566 34786856
Lung cancer metastatic 10.69 10.28 33 163476 2754 34790668
Major depression 10.68 10.28 4 163505 4568 34788854
Treatment failure 10.64 10.28 290 163219 46407 34747015
Influenza 10.63 10.28 306 163203 49360 34744062
Encopresis 10.62 10.28 8 163501 178 34793244
Kyphosis 10.60 10.28 20 163489 1216 34792206
Pyelocaliectasis 10.60 10.28 19 163490 1111 34792311
Muscle twitching 10.59 10.28 20 163489 10278 34783144
Potentiating drug interaction 10.59 10.28 5 163504 4972 34788450
Pancreatic duct stenosis 10.58 10.28 8 163501 179 34793243
Cleft palate 10.51 10.28 14 163495 631 34792791
Thinking abnormal 10.49 10.28 8 163501 6129 34787293
Live birth 10.47 10.28 9 163500 243 34793179
Chronic obstructive pulmonary disease 10.37 10.28 301 163208 48617 34744805
Agranulocytosis 10.35 10.28 67 163442 23754 34769668
Second primary malignancy 10.33 10.28 13 163496 7873 34785549
Fracture 10.32 10.28 61 163448 6788 34786634
Skin lesion 10.29 10.28 152 163357 21809 34771613
Ulna fracture 10.29 10.28 11 163498 392 34793030

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1383.30 9.72 3629 497644 204841 79038274
Arthropathy 1106.65 9.72 3016 498257 174095 79069020
Completed suicide 1068.31 9.72 141 501132 245626 78997489
Joint swelling 1065.34 9.72 4104 497169 284542 78958573
Pemphigus 1062.69 9.72 2094 499179 97488 79145627
Systemic lupus erythematosus 1060.97 9.72 2349 498924 118800 79124315
Hand deformity 1033.49 9.72 2122 499151 101797 79141318
Synovitis 1024.84 9.72 2649 498624 148085 79095030
Toxicity to various agents 939.20 9.72 764 500509 420776 78822339
Glossodynia 925.49 9.72 2022 499251 101315 79141800
Arthralgia 827.02 9.72 6282 494991 565521 78677594
Anti-cyclic citrullinated peptide antibody positive 796.31 9.72 1672 499601 81471 79161644
Infusion related reaction 786.27 9.72 3196 498077 227041 79016074
Wound 771.19 9.72 2024 499249 114155 79128960
Maternal exposure during pregnancy 744.17 9.72 2214 499059 134324 79108791
Pericarditis 716.50 9.72 1840 499433 102396 79140719
Drug abuse 698.05 9.72 97 501176 162594 79080521
Pain 623.79 9.72 6959 494314 696843 78546272
Abdominal discomfort 620.30 9.72 3165 498108 247562 78995553
Therapeutic product effect decreased 602.82 9.72 2329 498944 161534 79081581
Discomfort 582.22 9.72 1926 499347 123691 79119424
Swelling 580.95 9.72 2799 498474 213912 79029203
Alopecia 566.98 9.72 2913 498360 228442 79014673
Contraindicated product administered 545.44 9.72 2197 499076 155341 79087774
Duodenal ulcer perforation 505.65 9.72 1217 500056 64994 79178121
Musculoskeletal stiffness 505.23 9.72 2310 498963 172698 79070417
Drug intolerance 503.10 9.72 3108 498165 261011 78982104
Helicobacter infection 502.37 9.72 1253 500020 68451 79174664
Rheumatoid factor positive 483.11 9.72 1124 500149 58715 79184400
Drug interaction 474.81 9.72 1206 500067 413977 78829138
Death 470.26 9.72 1900 499373 564614 78678501
Nasopharyngitis 442.37 9.72 2921 498352 250960 78992155
Hepatic enzyme increased 442.12 9.72 2292 498981 180318 79062797
Psoriatic arthropathy 409.79 9.72 1249 500024 76750 79166365
Intentional overdose 382.50 9.72 97 501176 105863 79137252
Exposure during pregnancy 357.53 9.72 1420 499853 99712 79143403
Acute kidney injury 356.99 9.72 1866 499407 517538 78725577
Impaired healing 325.44 9.72 1250 500023 86405 79156710
Treatment failure 325.41 9.72 2008 499265 168478 79074637
C-reactive protein abnormal 323.08 9.72 845 500428 47522 79195593
Hypersensitivity 296.32 9.72 2729 498544 259510 78983605
Lower respiratory tract infection 286.77 9.72 1584 499689 127636 79115479
Muscle injury 285.00 9.72 809 500464 47752 79195363
Febrile neutropenia 283.49 9.72 646 500627 230353 79012762
Folliculitis 282.64 9.72 878 500395 54502 79188613
Irritable bowel syndrome 270.25 9.72 934 500339 61307 79181808
Product use issue 268.33 9.72 2244 499029 207578 79035537
Sinusitis 265.16 9.72 2119 499154 193382 79049733
Peripheral swelling 262.59 9.72 2720 498553 266897 78976218
Cardiac arrest 261.09 9.72 424 500849 171672 79071443
Blister 258.08 9.72 1454 499819 118022 79125093
Sleep disorder due to general medical condition, insomnia type 250.15 9.72 720 500553 42836 79200279
Red blood cell sedimentation rate abnormal 239.48 9.72 454 500819 20509 79222606
Overdose 239.31 9.72 499 500774 183707 79059408
Suicide attempt 232.66 9.72 115 501158 82817 79160298
Depressed level of consciousness 228.98 9.72 164 501109 96488 79146627
Disease progression 227.43 9.72 514 500759 183848 79059267
Knee arthroplasty 226.58 9.72 692 500581 42556 79200559
Sickle cell anaemia with crisis 226.19 9.72 264 501009 7658 79235457
Arthritis 224.73 9.72 1362 499911 113518 79129597
Blood pressure fluctuation 216.07 9.72 916 500357 66229 79176886
Bradycardia 216.06 9.72 323 500950 135234 79107881
Hip arthroplasty 208.17 9.72 594 500679 35162 79207953
Osteoarthritis 206.34 9.72 1089 500184 86220 79156895
Weight increased 199.52 9.72 2640 498633 274746 78968369
Rhabdomyolysis 191.80 9.72 219 501054 102912 79140203
Infection 188.84 9.72 2336 498937 239376 79003739
Rheumatic fever 187.06 9.72 495 500778 28030 79215085
Renal failure 179.09 9.72 654 500619 200314 79042801
Lactic acidosis 171.14 9.72 116 501157 70243 79172872
Condition aggravated 171.13 9.72 4240 497033 496884 78746231
Malignant neoplasm progression 171.07 9.72 375 500898 135615 79107500
Fibromyalgia 169.17 9.72 827 500446 63513 79179602
Respiratory arrest 168.83 9.72 75 501198 57475 79185640
Drug reaction with eosinophilia and systemic symptoms 168.58 9.72 97 501176 64147 79178968
Blood pressure systolic increased 162.73 9.72 842 500431 66144 79176971
Sedation 161.34 9.72 62 501211 51833 79191282
Ill-defined disorder 159.31 9.72 827 500446 65048 79178067
Swollen joint count increased 155.59 9.72 403 500870 22524 79220591
Cardiac failure 154.25 9.72 480 500793 154362 79088753
Red blood cell sedimentation rate increased 152.67 9.72 633 500640 45309 79197806
Blood pressure systolic abnormal 151.40 9.72 335 500938 16912 79226203
Neutropenia 150.41 9.72 1124 500149 286586 78956529
Blood pressure diastolic abnormal 148.73 9.72 355 500918 18847 79224268
Serotonin syndrome 146.42 9.72 50 501223 44977 79198138
Sopor 145.53 9.72 18 501255 32992 79210123
Constipation 144.55 9.72 1113 500160 281937 78961178
Contusion 143.73 9.72 1499 499774 147277 79095838
Hypotension 143.41 9.72 1928 499345 438389 78804726
Pregnancy 142.85 9.72 432 500841 26419 79216696
Abortion spontaneous 138.85 9.72 455 500818 29052 79214063
Agitation 136.40 9.72 262 501011 99453 79143662
Hepatic function abnormal 135.10 9.72 156 501117 72951 79170164
Inflammation 133.48 9.72 1028 500245 92725 79150390
Coma 131.20 9.72 272 501001 100377 79142738
Drug ineffective 131.08 9.72 8162 493111 1072751 78170364
Joint effusion 130.95 9.72 325 500948 17689 79225426
Respiratory failure 130.12 9.72 639 500634 180272 79062843
Psoriasis 128.48 9.72 984 500289 88603 79154512
C-reactive protein increased 127.46 9.72 1306 499967 127721 79115394
Drug resistance 125.42 9.72 54 501219 42159 79200956
Grip strength decreased 124.09 9.72 360 500913 21509 79221606
Hypoglycaemia 119.81 9.72 290 500983 101304 79141811
Renal impairment 117.13 9.72 551 500722 157232 79085883
Electrocardiogram QT prolonged 115.51 9.72 247 501026 90139 79152976
Rash 115.31 9.72 4585 496688 573773 78669342
Cardio-respiratory arrest 114.81 9.72 327 500946 108183 79134932
Stomatitis 113.93 9.72 1417 499856 145340 79097775
Somnolence 113.11 9.72 959 500314 238022 79005093
Blood pressure diastolic decreased 112.16 9.72 431 500842 29785 79213330
Drug dependence 112.14 9.72 58 501215 40711 79202404
Hyponatraemia 109.28 9.72 662 500611 177186 79065929
Joint stiffness 108.89 9.72 527 500746 40303 79202812
Hepatic failure 108.44 9.72 135 501138 61077 79182038
Tachycardia 108.03 9.72 664 500609 177104 79066011
Hyperhidrosis 107.83 9.72 537 500736 150955 79092160
Intentional product use issue 107.68 9.72 1444 499829 150668 79092447
Enthesopathy 107.05 9.72 230 501043 11378 79231737
Rheumatoid nodule 106.70 9.72 295 500978 17143 79225972
Blood cholesterol increased 106.66 9.72 895 500378 82825 79160290
Musculoskeletal pain 106.37 9.72 1047 500226 101307 79141808
Foot deformity 105.98 9.72 363 500910 23711 79219404
Osteoporosis 104.14 9.72 639 500634 53473 79189642
Hyperglycaemia 104.08 9.72 176 501097 70159 79172956
Pain in extremity 102.95 9.72 3010 498263 361528 78881587
Hypoxia 102.12 9.72 321 500952 102922 79140193
Intentional self-injury 101.99 9.72 38 501235 32381 79210734
Neoplasm progression 101.33 9.72 105 501168 51577 79191538
Angioedema 99.50 9.72 205 501068 75830 79167285
Gastrointestinal disorder 98.76 9.72 1189 500084 121016 79122099
Multiple organ dysfunction syndrome 98.28 9.72 405 500868 119841 79123274
Disability assessment scale score increased 96.66 9.72 114 501159 3344 79239771
Live birth 96.37 9.72 298 500975 18446 79224669
Bone erosion 95.74 9.72 288 500985 17559 79225556
Cytomegalovirus infection 95.05 9.72 77 501196 42567 79200548
Heart rate decreased 94.57 9.72 761 500512 69555 79173560
Intentional product misuse 94.04 9.72 296 500977 94869 79148246
Fatigue 93.92 9.72 6916 494357 922811 78320304
Metabolic acidosis 93.85 9.72 240 501033 82289 79160826
Cardiac failure congestive 93.39 9.72 519 500754 141883 79101232
Poisoning 93.39 9.72 22 501251 25250 79217865
Altered state of consciousness 92.93 9.72 83 501190 43739 79199376
Device expulsion 92.67 9.72 24 501249 25837 79217278
Tenosynovitis 92.09 9.72 260 501013 15294 79227821
Thrombocytopenia 90.82 9.72 1149 500124 264110 78979005
Neuropathy peripheral 89.96 9.72 520 500753 140785 79102330
Juvenile idiopathic arthritis 87.91 9.72 128 501145 4635 79238480
Syncope 87.65 9.72 714 500559 178735 79064380
Joint range of motion decreased 87.61 9.72 428 500845 32854 79210261
Palmar-plantar erythrodysaesthesia syndrome 86.96 9.72 50 501223 33084 79210031
Dehydration 86.10 9.72 1072 500201 247115 78996000
Injection site erythema 83.74 9.72 805 500468 77392 79165723
Drug withdrawal syndrome 83.41 9.72 58 501215 34660 79208455
Respiratory depression 82.64 9.72 35 501238 27595 79215520
Pulmonary fibrosis 80.57 9.72 514 500759 43598 79199517
Polyarthritis 80.25 9.72 212 501061 11990 79231125
Cognitive disorder 79.78 9.72 203 501070 69723 79173392
Tremor 79.78 9.72 684 500589 169399 79073716
Loss of personal independence in daily activities 79.39 9.72 990 500283 101590 79141525
Shock 79.30 9.72 94 501179 43454 79199661
Joint destruction 78.69 9.72 137 501136 5788 79237327
Product use in unapproved indication 77.87 9.72 1106 500167 249253 78993862
Ventricular tachycardia 76.92 9.72 90 501183 41845 79201270
Seizure 76.74 9.72 787 500486 188047 79055068
Blood creatine phosphokinase increased 76.07 9.72 191 501082 65899 79177216
Disseminated intravascular coagulation 75.87 9.72 68 501205 35774 79207341
Mobility decreased 75.30 9.72 1132 500141 121043 79122072
Hallucination 75.03 9.72 281 500992 85464 79157651
Localised infection 75.02 9.72 448 500825 37127 79205988
Injection site pruritus 74.96 9.72 489 500784 41794 79201321
Asthenia 74.13 9.72 2553 498720 509136 78733979
Caesarean section 73.69 9.72 209 501064 12326 79230789
Injection site reaction 72.62 9.72 591 500682 54194 79188921
Cerebral haemorrhage 72.52 9.72 159 501114 57514 79185601
Myocardial infarction 71.73 9.72 775 500498 183354 79059761
Immune reconstitution inflammatory syndrome 70.69 9.72 4 501269 13837 79229278
Cholestasis 70.31 9.72 138 501135 51971 79191144
Mydriasis 70.05 9.72 13 501260 17630 79225485
Dyspnoea 69.26 9.72 4551 496722 852474 78390641
Anaemia 68.76 9.72 2202 499071 442813 78800302
Disturbance in attention 68.14 9.72 135 501138 50666 79192449
Encephalopathy 67.74 9.72 208 501065 67189 79175926
Type 2 diabetes mellitus 67.69 9.72 601 500672 56521 79186594
Vomiting 66.99 9.72 3462 497811 662366 78580749
Joint laxity 66.73 9.72 78 501195 2266 79240849
Hyperkalaemia 66.54 9.72 433 500840 113965 79129150
Drug ineffective for unapproved indication 66.31 9.72 139 501134 51099 79192016
Disability 65.85 9.72 247 501026 16873 79226242
Blood pressure diastolic increased 65.53 9.72 221 501052 14321 79228794
Cytokine release syndrome 65.23 9.72 78 501195 35920 79207195
Basal cell carcinoma 64.89 9.72 430 500843 36945 79206170
Myalgia 64.30 9.72 802 500471 184839 79058276
Hepatocellular injury 64.24 9.72 126 501147 47467 79195648
Acute hepatic failure 63.90 9.72 57 501216 30056 79213059
Neuroleptic malignant syndrome 63.65 9.72 48 501225 27511 79215604
Gestational diabetes 63.05 9.72 129 501144 6164 79236951
Nodule 62.90 9.72 299 500974 22695 79220420
Tendonitis 62.40 9.72 306 500967 23524 79219591
Body temperature decreased 62.10 9.72 380 500893 31765 79211350
Blood pressure increased 61.99 9.72 1754 499519 209606 79033509
Suicidal ideation 61.82 9.72 258 501015 76082 79167033
Orthostatic hypotension 61.82 9.72 166 501107 55998 79187117
Abnormal behaviour 61.75 9.72 83 501190 36338 79206777
Mental status changes 61.52 9.72 215 501058 66744 79176371
Sedation complication 61.24 9.72 12 501261 15657 79227458
Red blood cell sedimentation rate 60.46 9.72 118 501155 5447 79237668
Anxiety 60.38 9.72 1149 500124 247363 78995752
Restlessness 60.27 9.72 126 501147 46366 79196749
Blood glucose increased 60.08 9.72 449 500824 114526 79128589
Diarrhoea 60.02 9.72 4744 496529 875745 78367370
Adverse event 59.67 9.72 610 500663 59604 79183511
Post transplant lymphoproliferative disorder 59.53 9.72 3 501270 11461 79231654
Nausea 59.27 9.72 5197 496076 951999 78291116
Tongue disorder 59.15 9.72 208 501065 13767 79229348
Anaphylactic shock 59.05 9.72 84 501189 35912 79207203
Diabetic ketoacidosis 58.63 9.72 77 501196 34045 79209070
Vision blurred 58.50 9.72 407 500866 105491 79137624
Ejection fraction decreased 58.42 9.72 79 501194 34498 79208617
Unresponsive to stimuli 58.35 9.72 169 501104 55619 79187496
Alanine aminotransferase abnormal 58.26 9.72 154 501119 8713 79234402
Psychotic disorder 58.17 9.72 107 501166 41295 79201820
Atrial fibrillation 57.76 9.72 885 500388 197001 79046114
Leukopenia 57.60 9.72 462 500811 116051 79127064
Neurotoxicity 57.30 9.72 72 501201 32446 79210669
Joint injury 57.15 9.72 365 500908 30970 79212145
Neutrophil count decreased 56.51 9.72 352 500921 93607 79149508
Infective pulmonary exacerbation of cystic fibrosis 54.29 9.72 8 501265 12843 79230272
Disorientation 54.09 9.72 207 501066 62569 79180546
Balance disorder 54.09 9.72 381 500892 98476 79144639
Laryngitis 54.07 9.72 222 501051 15817 79227298
Multiple sclerosis relapse 53.93 9.72 134 501139 46399 79196716
Drug level increased 53.50 9.72 105 501168 39546 79203569
Myoclonus 53.31 9.72 57 501216 27603 79215512
No adverse event 53.26 9.72 95 501178 37097 79206018
Bursitis 52.09 9.72 395 500878 35449 79207666
Irritability 52.09 9.72 113 501160 41031 79202084
Hypothermia 52.04 9.72 40 501233 22706 79220409
Injection site swelling 51.84 9.72 488 500785 46644 79196471
Skin ulcer 51.02 9.72 543 500730 53607 79189508
Inappropriate antidiuretic hormone secretion 50.97 9.72 54 501219 26259 79216856
Injection site pain 50.70 9.72 1120 500153 128718 79114397
Speech disorder 50.57 9.72 174 501099 54271 79188844
Venoocclusive liver disease 50.49 9.72 7 501266 11764 79231351
Melaena 50.41 9.72 204 501069 60686 79182429
Oropharyngeal pain 50.16 9.72 966 500307 108387 79134728
Dizziness 49.73 9.72 2754 498519 523687 78719428
Blood parathyroid hormone decreased 49.14 9.72 162 501111 10374 79232741
Therapeutic response decreased 49.08 9.72 639 500634 66214 79176901
Femur fracture 48.57 9.72 412 500861 38240 79204875
Substance abuse 48.26 9.72 5 501268 10521 79232594
Synovial cyst 48.06 9.72 156 501117 9909 79233206
Extrapyramidal disorder 48.03 9.72 43 501230 22636 79220479
Aggression 47.91 9.72 162 501111 50796 79192319
Pulmonary arterial hypertension 47.73 9.72 65 501208 28301 79214814
Hypokalaemia 47.38 9.72 629 500644 143411 79099704
Granuloma skin 47.30 9.72 146 501127 9028 79234087
Injection site bruising 46.84 9.72 428 500845 40574 79202541
Torsade de pointes 46.74 9.72 32 501241 19280 79223835
Respiratory distress 46.71 9.72 198 501075 58141 79184974
Latent tuberculosis 46.46 9.72 79 501194 3274 79239841
Lip dry 46.26 9.72 206 501067 15212 79227903
Tenderness 45.99 9.72 280 500993 23362 79219753
Proteinuria 45.66 9.72 84 501189 32418 79210697
Fracture 45.50 9.72 263 501010 21538 79221577
Brain oedema 45.50 9.72 55 501218 25208 79217907
Posterior reversible encephalopathy syndrome 45.47 9.72 59 501214 26222 79216893
Blood creatinine increased 45.39 9.72 693 500580 154364 79088751
Cerebral infarction 45.16 9.72 142 501131 45534 79197581
Facet joint syndrome 45.09 9.72 165 501108 11137 79231978
Tuberculosis 44.80 9.72 202 501071 14996 79228119
Aspergillus infection 44.73 9.72 33 501240 19128 79223987
Loss of consciousness 44.71 9.72 764 500509 167179 79075936
Delirium 44.44 9.72 330 500943 84297 79158818
Pulmonary embolism 44.38 9.72 785 500488 170869 79072246
Miosis 44.11 9.72 22 501251 15767 79227348
Dysarthria 44.02 9.72 247 501026 67375 79175740
Creatinine renal clearance decreased 44.00 9.72 33 501240 18969 79224146
Gastrointestinal haemorrhage 44.00 9.72 658 500615 147061 79096054
Neck deformity 43.97 9.72 56 501217 1781 79241334
Coagulopathy 43.85 9.72 101 501172 35905 79207210
Arrhythmia 43.68 9.72 217 501056 61055 79182060
Pathogen resistance 43.16 9.72 18 501255 14324 79228791
Agranulocytosis 43.12 9.72 142 501131 44888 79198227
Peripheral venous disease 42.88 9.72 206 501067 15703 79227412
Fluid retention 42.77 9.72 260 501013 69549 79173566
Wrong technique in product usage process 42.76 9.72 280 500993 73595 79169520
Akathisia 42.63 9.72 15 501258 13244 79229871
Platelet count decreased 42.49 9.72 916 500357 193748 79049367
Gamma-glutamyltransferase increased 42.31 9.72 188 501085 54492 79188623
Ear infection 42.21 9.72 365 500908 34067 79209048
Coronary artery disease 42.16 9.72 240 501033 65234 79177881
Sepsis 42.06 9.72 1331 499942 268097 78975018
Maternal exposure before pregnancy 41.89 9.72 88 501185 4285 79238830
Withdrawal syndrome 41.78 9.72 65 501208 26789 79216326
Asphyxia 41.76 9.72 11 501262 11709 79231406
General physical health deterioration 41.31 9.72 2121 499152 273117 78969998
Acute chest syndrome 41.23 9.72 50 501223 1511 79241604
Premature labour 40.93 9.72 131 501142 8259 79234856
Pulmonary oedema 40.88 9.72 356 500917 87898 79155217
Chronic kidney disease 40.73 9.72 246 501027 65908 79177207
Psychomotor hyperactivity 40.67 9.72 28 501245 16821 79226294
Thrombotic microangiopathy 40.65 9.72 40 501233 20129 79222986
Fear of injection 40.46 9.72 121 501152 7353 79235762
Emotional distress 40.41 9.72 123 501150 39846 79203269
Ankylosing spondylitis 40.41 9.72 168 501105 12037 79231078
Cerebrovascular accident 40.20 9.72 710 500563 154582 79088533
Premature delivery 40.14 9.72 269 501004 23198 79219917
Second primary malignancy 40.08 9.72 20 501253 14330 79228785
Pre-eclampsia 40.03 9.72 116 501157 6925 79236190
Drug use disorder 39.94 9.72 4 501269 8647 79234468
Haematotoxicity 39.90 9.72 24 501249 15495 79227620
Blood bilirubin increased 39.88 9.72 248 501025 65984 79177131
Transplant rejection 39.81 9.72 38 501235 19399 79223716
White blood cell count decreased 39.66 9.72 891 500382 187397 79055718
Bronchopulmonary aspergillosis 39.66 9.72 49 501224 22245 79220870
Exostosis 39.61 9.72 210 501063 16648 79226467
Maternal exposure timing unspecified 39.49 9.72 102 501171 5690 79237425
Panniculitis 39.18 9.72 168 501105 12203 79230912
Joint dislocation 39.11 9.72 210 501063 16729 79226386
Blood alkaline phosphatase increased 39.06 9.72 237 501036 63427 79179688
Dyskinesia 38.99 9.72 147 501126 44626 79198489
Deep vein thrombosis postoperative 38.79 9.72 152 501121 10600 79232515
Wheelchair user 38.77 9.72 105 501168 6027 79237088
Ulcer 38.47 9.72 321 500952 29651 79213464
Exposure to toxic agent 38.00 9.72 6 501267 9152 79233963
Multiple fractures 37.97 9.72 124 501149 7902 79235213
Poor venous access 37.91 9.72 219 501054 17930 79225185
Liver injury 37.80 9.72 532 500741 56082 79187033
Lupus-like syndrome 37.77 9.72 180 501093 13677 79229438
Leukocytosis 37.62 9.72 143 501130 43312 79199803
Sciatica 37.55 9.72 346 500927 32876 79210239
Acute graft versus host disease 37.27 9.72 9 501264 10158 79232957
Tumour lysis syndrome 37.19 9.72 58 501215 23881 79219234
Unintentional medical device removal 37.13 9.72 3 501270 7709 79235406
Dystonia 37.06 9.72 48 501225 21351 79221764
Acute respiratory distress syndrome 36.88 9.72 147 501126 43920 79199195
Premature rupture of membranes 36.81 9.72 80 501193 3989 79239126
Limb deformity 36.45 9.72 74 501199 3516 79239599
Chest discomfort 36.41 9.72 629 500644 137415 79105700
Rash maculo-papular 36.41 9.72 205 501068 55873 79187242
Drug tolerance decreased 36.41 9.72 170 501103 12808 79230307
BK virus infection 36.01 9.72 6 501267 8798 79234317
Deep vein thrombosis 35.88 9.72 539 500734 120380 79122735
Neck mass 35.82 9.72 83 501190 4321 79238794
Anti-cyclic citrullinated peptide antibody 35.80 9.72 99 501174 5753 79237362
Arthritis infective 35.78 9.72 124 501149 8147 79234968
Adjustment disorder with depressed mood 35.70 9.72 132 501141 8954 79234161
Osteonecrosis of jaw 35.67 9.72 145 501128 43081 79200034
Haemorrhage intracranial 35.65 9.72 69 501204 26124 79216991
Fear 35.38 9.72 52 501221 21934 79221181
Haemoptysis 35.13 9.72 207 501066 55792 79187323
Forced expiratory volume decreased 35.09 9.72 4 501269 7810 79235305
Retinitis 35.05 9.72 96 501177 5547 79237568
Status epilepticus 34.93 9.72 65 501208 24976 79218139
Feeling abnormal 34.77 9.72 749 500524 158450 79084665
Aphasia 34.77 9.72 163 501110 46569 79196546
Product quality issue 34.63 9.72 104 501169 33836 79209279
Flushing 34.56 9.72 371 500902 87897 79155218
Bradyphrenia 34.27 9.72 12 501261 10628 79232487
Decreased appetite 34.21 9.72 1781 499492 340637 78902478
Ischaemic stroke 34.18 9.72 101 501172 33030 79210085
Herpes zoster 34.16 9.72 796 500477 92287 79150828
Smear cervix abnormal 34.15 9.72 59 501214 2477 79240638
Toxic epidermal necrolysis 34.06 9.72 154 501119 44427 79198688
Injection site rash 33.90 9.72 211 501062 17743 79225372
Mouth ulceration 33.86 9.72 380 500893 38014 79205101
Eosinophilia 33.83 9.72 158 501115 45187 79197928
Malignant mediastinal neoplasm 33.65 9.72 43 501230 1372 79241743
Clostridium difficile colitis 33.61 9.72 98 501175 32185 79210930
Wound infection 33.53 9.72 262 501011 23729 79219386
Pancreatitis acute 33.48 9.72 179 501094 49425 79193690
Dysgeusia 33.45 9.72 216 501057 56961 79186154
Acute respiratory failure 33.29 9.72 228 501045 59313 79183802
Therapeutic product effect incomplete 33.17 9.72 1144 500129 140501 79102614
Dislocation of vertebra 33.10 9.72 117 501156 7763 79235352
Subdural haematoma 33.03 9.72 95 501178 31339 79211776
Obesity 32.98 9.72 352 500921 34773 79208342
Acute generalised exanthematous pustulosis 32.76 9.72 36 501237 17218 79225897
Spinal stenosis 32.63 9.72 190 501083 15601 79227514
Mania 32.62 9.72 40 501233 18220 79224895
Depression 32.62 9.72 1076 500197 215714 79027401
Muscle twitching 32.19 9.72 67 501206 24697 79218418
Tachypnoea 32.18 9.72 99 501174 31964 79211151
Tenosynovitis stenosans 31.91 9.72 64 501209 3014 79240101
Pleural effusion 31.85 9.72 683 500590 144579 79098536
Dysphagia 31.73 9.72 558 500715 121578 79121537
Anaphylactic reaction 31.58 9.72 355 500918 83388 79159727
Acidosis 31.55 9.72 47 501226 19715 79223400
Myelosuppression 31.50 9.72 138 501135 40158 79202957
Haemorrhage 31.39 9.72 394 500879 90724 79152391
Rotator cuff repair 31.29 9.72 48 501225 1822 79241293
Foot fracture 31.25 9.72 241 501032 21740 79221375
Graft versus host disease 31.21 9.72 29 501244 14997 79228118
Immunodeficiency 31.13 9.72 239 501034 21529 79221586
Haemophagocytic lymphohistiocytosis 31.07 9.72 56 501217 21781 79221334
Ascites 31.05 9.72 314 500959 75248 79167867
Scleritis 31.04 9.72 78 501195 4278 79238837
Hyperthermia 30.68 9.72 41 501232 17996 79225119
Synovial fluid analysis 30.62 9.72 54 501219 2305 79240810
Glycosylated haemoglobin increased 30.56 9.72 46 501227 19214 79223901
Pulmonary alveolar haemorrhage 30.48 9.72 17 501256 11440 79231675
Sinus tachycardia 30.33 9.72 124 501149 36784 79206331
Rheumatoid lung 30.23 9.72 76 501197 4169 79238946
Pulmonary hypertension 30.01 9.72 178 501095 47902 79195213
Angina pectoris 29.97 9.72 196 501077 51536 79191579
Oral herpes 29.56 9.72 283 500990 27171 79215944
Cytopenia 29.24 9.72 52 501221 20331 79222784
Stress cardiomyopathy 29.09 9.72 17 501256 11149 79231966
Face oedema 28.86 9.72 86 501187 28050 79215065
Device difficult to use 28.80 9.72 25 501248 13360 79229755
Cardiomyopathy 28.77 9.72 89 501184 28685 79214430
Hallucination, auditory 28.61 9.72 54 501219 20639 79222476
Bone pain 28.48 9.72 219 501054 55523 79187592
Gastroenteritis viral 28.26 9.72 259 501014 24572 79218543
Disease recurrence 28.23 9.72 162 501111 43947 79199168
Hyperbilirubinaemia 28.10 9.72 71 501202 24447 79218668
Bone disorder 27.98 9.72 211 501062 18902 79224213
Pancytopenia 27.94 9.72 1292 499981 164453 79078662
Plasma cell myeloma 27.80 9.72 208 501065 53051 79190064
Stevens-Johnson syndrome 27.75 9.72 139 501134 39027 79204088
Acute graft versus host disease in skin 27.64 9.72 7 501266 7651 79235464
Weight decreased 27.59 9.72 2592 498681 352606 78890509
Hallucination, visual 27.50 9.72 109 501164 32620 79210495
Hemiplegia 27.46 9.72 32 501241 14907 79228208
Muscle rigidity 27.39 9.72 52 501221 19830 79223285
Pancreatitis 27.34 9.72 287 500986 68288 79174827
Urinary retention 27.32 9.72 226 501047 56404 79186711
Therapy non-responder 27.31 9.72 767 500506 91538 79151577
Muscle spasms 27.29 9.72 863 500410 173867 79069248
Shock haemorrhagic 27.16 9.72 53 501220 20007 79223108
Loose body in joint 27.16 9.72 37 501236 1258 79241857
Rhinorrhoea 27.13 9.72 648 500625 75426 79167689
Skin papilloma 27.00 9.72 90 501183 5796 79237319
Pneumatosis intestinalis 26.98 9.72 4 501269 6393 79236722
Dyspnoea exertional 26.91 9.72 385 500888 86688 79156427
Graft versus host disease in gastrointestinal tract 26.75 9.72 4 501269 6352 79236763
Skin cancer 26.69 9.72 174 501099 14866 79228249
Palpitations 26.69 9.72 599 500674 126011 79117104
Accidental overdose 26.62 9.72 143 501130 39438 79203677
Blood pressure decreased 26.62 9.72 452 500821 99014 79144101
Hypomagnesaemia 26.54 9.72 179 501094 46732 79196383
Cyanosis 26.54 9.72 76 501197 25106 79218009
Synovial disorder 26.53 9.72 46 501227 1937 79241178
Respiration abnormal 26.47 9.72 8 501265 7780 79235335
Malignant melanoma 26.44 9.72 171 501102 14570 79228545
Finger deformity 26.43 9.72 105 501168 7369 79235746
Anhedonia 26.23 9.72 33 501240 14865 79228250
Blood calcium decreased 26.09 9.72 107 501166 31712 79211403
Hemiparesis 26.08 9.72 116 501157 33617 79209498
Influenza 26.04 9.72 1029 500244 128577 79114538
Autoimmune disorder 25.81 9.72 186 501087 16426 79226689
Colorectal cancer 25.78 9.72 11 501262 8636 79234479
Jaundice 25.69 9.72 213 501060 53136 79189979
Bronchospasm 25.49 9.72 76 501197 24783 79218332
Klebsiella infection 25.47 9.72 37 501236 15683 79227432
Hepatitis B reactivation 25.35 9.72 4 501269 6104 79237011
Rebound effect 25.33 9.72 7 501266 7219 79235896
Sinus bradycardia 25.30 9.72 78 501195 25169 79217946
Metastases to liver 25.28 9.72 92 501181 28222 79214893
Nocardiosis 25.27 9.72 3 501270 5676 79237439
Cardiogenic shock 25.20 9.72 157 501116 41757 79201358
Cytomegalovirus viraemia 25.18 9.72 26 501247 12795 79230320
Oxygen saturation decreased 25.10 9.72 1021 500252 128026 79115089
Joint noise 25.08 9.72 68 501205 3906 79239209
Colitis ulcerative 25.05 9.72 331 500942 34411 79208704
Tardive dyskinesia 24.94 9.72 18 501255 10553 79232562
Pleuritic pain 24.91 9.72 128 501145 10024 79233091
Antinuclear antibody positive 24.87 9.72 107 501166 7783 79235332
Metastases to bone 24.82 9.72 75 501198 24352 79218763
Cardiac failure acute 24.79 9.72 51 501222 18878 79224237
Adenovirus infection 24.78 9.72 11 501262 8436 79234679
Lip swelling 24.73 9.72 153 501120 40758 79202357
Acute myeloid leukaemia 24.61 9.72 105 501168 30780 79212335
Sexual dysfunction 24.59 9.72 9 501264 7754 79235361
Toxic skin eruption 24.45 9.72 66 501207 22227 79220888
Prescribed overdose 24.10 9.72 353 500920 37530 79205585
Acute myocardial infarction 24.03 9.72 340 500933 76696 79166419
Hydrops foetalis 24.02 9.72 27 501246 751 79242364
Temperature regulation disorder 23.92 9.72 4 501269 5849 79237266
Chest pain 23.88 9.72 1492 499781 280812 78962303
Product administration error 23.73 9.72 111 501162 31735 79211380
Injection site warmth 23.71 9.72 167 501106 14640 79228475
Urticaria 23.60 9.72 938 500335 184263 79058852
Electrocardiogram QRS complex prolonged 23.60 9.72 20 501253 10813 79232302
Aspartate aminotransferase increased 23.56 9.72 677 500596 137964 79105151
Bacteraemia 23.54 9.72 116 501157 32708 79210407
Delusion 23.51 9.72 59 501214 20364 79222751
Asthma 23.39 9.72 658 500615 134437 79108678
Skin necrosis 23.36 9.72 194 501079 17893 79225222
Fracture delayed union 23.24 9.72 45 501228 2065 79241050
Human antichimeric antibody positive 23.18 9.72 39 501234 1602 79241513
Ultrasound antenatal screen 23.04 9.72 25 501248 668 79242447
Endophthalmitis 22.96 9.72 6 501267 6422 79236693
Vertigo 22.95 9.72 301 500972 68781 79174334
Cleft lip and palate 22.89 9.72 25 501248 673 79242442
Polyuria 22.74 9.72 37 501236 14977 79228138
Nephropathy toxic 22.73 9.72 60 501213 20359 79222756
Hypervolaemia 22.63 9.72 166 501107 42524 79200591
Progressive multifocal leukoencephalopathy 22.58 9.72 61 501212 20539 79222576
Breast cancer stage I 22.56 9.72 7 501266 6693 79236422
Polyneuropathy 22.55 9.72 77 501196 24074 79219041
Cystitis haemorrhagic 22.46 9.72 15 501258 9157 79233958
Drug tolerance 22.43 9.72 111 501162 8564 79234551
Pulseless electrical activity 22.29 9.72 34 501239 14126 79228989
Lymphocyte count decreased 22.23 9.72 190 501083 47099 79196016
Ileus 22.21 9.72 87 501186 26124 79216991
Hepatic encephalopathy 21.92 9.72 78 501195 24088 79219027
Lethargy 21.88 9.72 369 500904 80923 79162192
Anger 21.83 9.72 47 501226 17115 79226000
Haematoma 21.82 9.72 216 501057 51979 79191136
Visual acuity reduced 21.80 9.72 103 501170 29366 79213749
Peripheral sensory neuropathy 21.79 9.72 30 501243 13003 79230112
Paranoia 21.71 9.72 57 501216 19375 79223740
Ventricular fibrillation 21.66 9.72 115 501158 31811 79211304
Blood lactic acid increased 21.65 9.72 29 501244 12715 79230400
Dry skin 21.60 9.72 299 500974 67696 79175419
Coordination abnormal 21.54 9.72 48 501225 17264 79225851
Foot operation 21.46 9.72 82 501191 5651 79237464
Pain in jaw 21.44 9.72 186 501087 45965 79197150
Hypertransaminasaemia 21.43 9.72 26 501247 11898 79231217
Hyperammonaemia 21.22 9.72 23 501250 11070 79232045
Ankle arthroplasty 21.22 9.72 36 501237 1489 79241626
Respiratory disorder 21.19 9.72 180 501093 44676 79198439
Frequent bowel movements 21.12 9.72 281 500992 29258 79213857
Lipase increased 21.03 9.72 45 501228 16421 79226694
Pyrexia 20.88 9.72 3853 497420 674856 78568259
Onychomycosis 20.86 9.72 105 501168 8156 79234959
Potentiating drug interaction 20.83 9.72 15 501258 8804 79234311
Metastases to central nervous system 20.70 9.72 45 501228 16330 79226785
Postoperative wound infection 20.64 9.72 146 501127 12815 79230300
Musculoskeletal disorder 20.63 9.72 216 501057 21232 79221883
Respiratory acidosis 20.58 9.72 24 501249 11176 79231939
Lower limb fracture 20.58 9.72 230 501043 22985 79220130
Polyhydramnios 20.58 9.72 38 501235 1682 79241433
Body height below normal 20.47 9.72 42 501231 2011 79241104
Cushingoid 20.44 9.72 116 501157 9436 79233679
Hyperlactacidaemia 20.42 9.72 5 501268 5590 79237525
Troponin increased 20.37 9.72 58 501215 19197 79223918
Polydipsia 20.35 9.72 8 501265 6597 79236518
Trisomy 18 20.30 9.72 22 501251 587 79242528
Labelled drug-drug interaction medication error 20.24 9.72 97 501176 27553 79215562
Bronchitis 20.24 9.72 1010 500263 129634 79113481
Device leakage 20.23 9.72 23 501250 10833 79232282
Gastric haemorrhage 20.17 9.72 40 501233 15010 79228105
Anuria 20.14 9.72 66 501207 20897 79222218
Atrioventricular block 19.98 9.72 36 501237 14005 79229110
Hyperthyroidism 19.94 9.72 72 501201 22137 79220978
Hyperuricaemia 19.89 9.72 27 501246 11772 79231343
Affective disorder 19.85 9.72 14 501259 8305 79234810
Device use error 19.68 9.72 10 501263 7091 79236024
Oliguria 19.66 9.72 46 501227 16263 79226852
Chronic graft versus host disease 19.63 9.72 9 501264 6772 79236343
End stage renal disease 19.57 9.72 29 501244 12191 79230924
Hyperprolactinaemia 19.55 9.72 3 501270 4673 79238442
Erythema multiforme 19.55 9.72 52 501221 17599 79225516
Multiple-drug resistance 19.51 9.72 16 501257 8792 79234323
Pemphigoid 19.44 9.72 42 501231 15273 79227842
Product prescribing error 19.34 9.72 184 501089 44629 79198486
Pulmonary congestion 19.30 9.72 96 501177 27004 79216111
Catatonia 19.27 9.72 16 501257 8740 79234375
Right ventricular failure 19.27 9.72 79 501194 23418 79219697
Bradypnoea 19.19 9.72 7 501266 6045 79237070
Breast feeding 19.12 9.72 23 501250 689 79242426
Muscle spasticity 19.03 9.72 70 501203 21405 79221710
Short stature 18.99 9.72 23 501250 694 79242421
Myocardial ischaemia 18.99 9.72 89 501184 25430 79217685
Venoocclusive disease 18.97 9.72 3 501270 4570 79238545
Mental disorder 18.95 9.72 117 501156 31185 79211930
Cholangitis 18.87 9.72 32 501241 12744 79230371
Interstitial lung disease 18.84 9.72 551 500722 112049 79131066
Surgery 18.80 9.72 300 500973 32466 79210649
Cardiotoxicity 18.68 9.72 30 501243 12209 79230906
Haemodynamic instability 18.66 9.72 52 501221 17330 79225785
Acute coronary syndrome 18.65 9.72 69 501204 21064 79222051
Hepatitis acute 18.60 9.72 44 501229 15498 79227617
Foetal distress syndrome 18.59 9.72 19 501254 473 79242642
Post procedural infection 18.58 9.72 129 501144 11255 79231860
Amylase increased 18.54 9.72 26 501247 11183 79231932
Toxic encephalopathy 18.47 9.72 27 501246 11413 79231702
Purpura 18.41 9.72 62 501211 19465 79223650
Ingrown hair 18.39 9.72 23 501250 718 79242397
Atrioventricular block complete 18.35 9.72 49 501224 16561 79226554
Sleep terror 18.32 9.72 3 501270 4455 79238660
Prostatic specific antigen increased 18.29 9.72 23 501250 10363 79232752
Cardiac failure chronic 18.25 9.72 26 501247 11109 79232006
Myopathy 18.24 9.72 67 501206 20496 79222619
Oesophageal carcinoma 18.05 9.72 26 501247 11058 79232057
Haematemesis 18.00 9.72 226 501047 52038 79191077
Hepatic cirrhosis 17.97 9.72 314 500959 34592 79208523
Erectile dysfunction 17.96 9.72 41 501232 14623 79228492
Epstein-Barr virus infection 17.91 9.72 40 501233 14376 79228739
Renal injury 17.90 9.72 51 501222 16876 79226239
Jaundice cholestatic 17.86 9.72 27 501246 11257 79231858
Antibody test positive 17.85 9.72 48 501225 2744 79240371
International normalised ratio increased 17.80 9.72 401 500872 84320 79158795
Stillbirth 17.73 9.72 60 501213 3895 79239220
Radiation inflammation 17.70 9.72 25 501248 880 79242235
Paralysis 17.68 9.72 35 501238 13142 79229973
Aphthous ulcer 17.65 9.72 173 501100 16716 79226399
Hepatitis fulminant 17.62 9.72 12 501261 7250 79235865
Skin exfoliation 17.60 9.72 242 501031 54858 79188257
Glomerular filtration rate decreased 17.59 9.72 78 501195 22624 79220491
Heart rate irregular 17.56 9.72 296 500977 32383 79210732
Presyncope 17.53 9.72 169 501104 40885 79202230
Heparin-induced thrombocytopenia 17.52 9.72 21 501252 9661 79233454
Anal fissure 17.45 9.72 95 501178 7608 79235507
Endodontic procedure 17.37 9.72 47 501226 2696 79240419
Intracranial pressure increased 17.36 9.72 16 501257 8306 79234809
Pulmonary haemorrhage 17.35 9.72 42 501231 14675 79228440
Pseudomonas infection 17.32 9.72 70 501203 20833 79222282
Therapy partial responder 17.26 9.72 54 501219 17343 79225772
Normal newborn 17.24 9.72 89 501184 6983 79236132
Dactylitis 17.22 9.72 47 501226 2710 79240405
Hypoalbuminaemia 17.22 9.72 72 501201 21225 79221890
Septic shock 17.18 9.72 615 500658 122186 79120929
Hypothyroidism 17.14 9.72 229 501044 52163 79190952
Febrile bone marrow aplasia 17.12 9.72 35 501238 12985 79230130
Placental disorder 17.11 9.72 25 501248 908 79242207
Sickle cell anaemia 17.10 9.72 21 501252 643 79242472
Foetal exposure during pregnancy 17.10 9.72 77 501196 5713 79237402
Unevaluable event 17.10 9.72 246 501027 55339 79187776
Bladder cancer 17.07 9.72 64 501209 19462 79223653
Incoherent 17.00 9.72 14 501259 7678 79235437
Tubulointerstitial nephritis 16.93 9.72 156 501117 38079 79205036
Induced labour 16.92 9.72 24 501249 848 79242267
C-reactive protein 16.85 9.72 69 501204 4910 79238205
Virologic failure 16.83 9.72 3 501270 4188 79238927
Lung transplant 16.79 9.72 4 501269 4557 79238558
Blood urea increased 16.79 9.72 211 501062 48579 79194536
Hepatitis cholestatic 16.75 9.72 39 501234 13813 79229302
Depressed mood 16.56 9.72 210 501063 48270 79194845
Nightmare 16.53 9.72 95 501178 25766 79217349
Lower respiratory tract congestion 16.49 9.72 59 501214 3938 79239177
Haematuria 16.47 9.72 319 500954 68517 79174598
Hypernatraemia 16.44 9.72 42 501231 14409 79228706
Tuberculin test positive 16.43 9.72 53 501220 3355 79239760
Tooth infection 16.43 9.72 186 501087 18646 79224469
Brain natriuretic peptide increased 16.43 9.72 19 501254 8881 79234234
Lacrimal disorder 16.29 9.72 18 501255 491 79242624
Generalised tonic-clonic seizure 16.22 9.72 187 501086 43723 79199392
Multiple drug therapy 16.20 9.72 3 501270 4075 79239040
Ventricular arrhythmia 16.18 9.72 19 501254 8821 79234294
Transplant dysfunction 16.14 9.72 13 501260 7208 79235907
Drug screen positive 16.12 9.72 9 501264 6054 79237061
Rhinitis allergic 16.11 9.72 33 501240 12236 79230879
Hyperlipidaemia 16.07 9.72 97 501176 25996 79217119
Myocarditis 16.05 9.72 76 501197 21657 79221458
Coronary arterial stent insertion 16.03 9.72 9 501264 6035 79237080
Accidental exposure to product 16.03 9.72 123 501150 31199 79211916
Renal tubular necrosis 16.00 9.72 92 501181 24947 79218168
Left ventricular dysfunction 15.94 9.72 65 501208 19296 79223819
Blood glucose decreased 15.91 9.72 98 501175 26136 79216979
Drug abuser 15.88 9.72 9 501264 6004 79237111
Generalised oedema 15.75 9.72 86 501187 23623 79219492
Atrial tachycardia 15.74 9.72 13 501260 7120 79235995
Onychomadesis 15.70 9.72 70 501203 5172 79237943
Cytomegalovirus infection reactivation 15.67 9.72 19 501254 8697 79234418
Eosinophil count increased 15.66 9.72 55 501218 17050 79226065
Pharyngitis 15.64 9.72 212 501061 22163 79220952
Multiple allergies 15.63 9.72 26 501247 10434 79232681
Rash erythematous 15.62 9.72 262 501011 57507 79185608
Metastases to lung 15.57 9.72 60 501213 18103 79225012
Cyst 15.57 9.72 144 501129 13696 79229419
Lymphatic fistula 15.44 9.72 22 501251 781 79242334
Hypercholesterolaemia 15.41 9.72 217 501056 22878 79220237
Haemorrhage in pregnancy 15.38 9.72 30 501243 1384 79241731
Hydrocephalus 15.37 9.72 20 501253 8880 79234235
Accidental death 15.34 9.72 4 501269 4287 79238828
Hypertriglyceridaemia 15.30 9.72 36 501237 12704 79230411
Injury 15.26 9.72 614 500659 76882 79166233
Ileus paralytic 15.24 9.72 23 501250 9597 79233518
C-reactive protein decreased 15.21 9.72 44 501229 2624 79240491
Pulmonary tuberculosis 15.20 9.72 93 501180 7772 79235343
Hypoxic-ischaemic encephalopathy 15.20 9.72 16 501257 7804 79235311
Clear cell renal cell carcinoma 15.19 9.72 43 501230 2533 79240582
Atrial flutter 15.17 9.72 77 501196 21548 79221567
Pulmonary pain 15.15 9.72 62 501211 4411 79238704
Knee operation 15.12 9.72 75 501198 5791 79237324
Maternal exposure during breast feeding 14.99 9.72 45 501228 2740 79240375
Hepatic cancer 14.98 9.72 27 501246 10502 79232613
Pharyngitis streptococcal 14.97 9.72 117 501156 10597 79232518
Renal disorder 14.90 9.72 181 501092 41924 79201191
Injection site extravasation 14.87 9.72 108 501165 9561 79233554
Hepatocellular carcinoma 14.85 9.72 21 501252 9000 79234115
Kidney transplant rejection 14.82 9.72 26 501247 10220 79232895
Cytomegalovirus chorioretinitis 14.82 9.72 8 501265 5482 79237633
Epistaxis 14.81 9.72 562 500711 110953 79132162
Wound infection pseudomonas 14.81 9.72 32 501241 1589 79241526
Haematocrit decreased 14.80 9.72 497 500776 60815 79182300
Type 1 diabetes mellitus 14.79 9.72 13 501260 6906 79236209
Dermatitis acneiform 14.78 9.72 25 501248 9968 79233147
Ligament rupture 14.78 9.72 51 501222 3343 79239772
Joint warmth 14.77 9.72 32 501241 1592 79241523
Intestinal ischaemia 14.77 9.72 39 501234 13231 79229884
Spinal osteoarthritis 14.68 9.72 167 501106 16760 79226355
Drug specific antibody 14.66 9.72 43 501230 2585 79240530
Hypocalcaemia 14.64 9.72 223 501050 49701 79193414
Femoral hernia incarcerated 14.64 9.72 22 501251 820 79242295
Metastasis 14.62 9.72 13 501260 6867 79236248
Deformity 14.61 9.72 107 501166 9498 79233617
Hypophagia 14.58 9.72 199 501074 45168 79197947
Osteoporotic fracture 14.54 9.72 59 501214 4181 79238934
Uterine perforation 14.53 9.72 11 501262 6292 79236823
Hypercapnia 14.51 9.72 21 501252 8914 79234201
Blood potassium increased 14.50 9.72 116 501157 29159 79213956
Joint ankylosis 14.46 9.72 38 501235 2142 79240973
Panic attack 14.41 9.72 91 501182 24125 79218990
Hospitalisation 14.33 9.72 467 500806 93769 79149346
Spinal disorder 14.31 9.72 112 501161 10148 79232967
Device related infection 14.30 9.72 142 501131 34152 79208963
Walking aid user 14.28 9.72 111 501162 10037 79233078
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.27 9.72 3 501270 3726 79239389
Diaphragmatic disorder 14.25 9.72 33 501240 1717 79241398
Nasal polyps 14.23 9.72 15 501258 7312 79235803
Bone density abnormal 14.23 9.72 47 501226 3013 79240102
Lymphoedema 14.18 9.72 36 501237 12377 79230738
Oligoarthritis 14.16 9.72 20 501253 704 79242411
Pneumothorax 14.13 9.72 112 501161 28211 79214904
Cervical incompetence 14.12 9.72 17 501256 510 79242605
Acute lymphocytic leukaemia recurrent 14.10 9.72 6 501267 4718 79238397
Tooth abscess 14.10 9.72 160 501113 16050 79227065
Subarachnoid haemorrhage 14.02 9.72 93 501180 24372 79218743
Bradykinesia 13.97 9.72 18 501255 8025 79235090
Plasma cell myeloma recurrent 13.92 9.72 7 501266 4994 79238121
Blood folate increased 13.88 9.72 17 501256 519 79242596
Dyslipidaemia 13.87 9.72 33 501240 11600 79231515
Labyrinthitis 13.82 9.72 45 501228 2863 79240252
Intervertebral disc degeneration 13.81 9.72 156 501117 15629 79227486
Mental impairment 13.81 9.72 67 501206 18969 79224146
Disturbance in social behaviour 13.77 9.72 7 501266 4963 79238152
Gestational hypertension 13.76 9.72 34 501239 1845 79241270
Motor dysfunction 13.74 9.72 47 501226 14686 79228429
Haemodialysis 13.73 9.72 63 501210 18105 79225010
Placental insufficiency 13.67 9.72 25 501248 1098 79242017
Joint lock 13.65 9.72 48 501225 3177 79239938
Foetal death 13.63 9.72 92 501181 7952 79235163
Respiratory tract infection viral 13.61 9.72 58 501215 4201 79238914
Human anti-human antibody test 13.61 9.72 15 501258 408 79242707
Hyperpyrexia 13.57 9.72 11 501262 6081 79237034
Metastases to meninges 13.57 9.72 3 501270 3598 79239517
Complications of transplanted kidney 13.57 9.72 12 501261 6354 79236761
Abortion threatened 13.55 9.72 15 501258 410 79242705
Parkinsonism 13.45 9.72 56 501217 16528 79226587
Capillary leak syndrome 13.40 9.72 4 501269 3921 79239194
Post procedural haemorrhage 13.39 9.72 43 501230 13701 79229414
Diplopia 13.36 9.72 140 501133 33326 79209789
Threatened labour 13.35 9.72 18 501255 606 79242509
Alcohol interaction 13.30 9.72 7 501266 4867 79238248
Systemic inflammatory response syndrome 13.29 9.72 33 501240 11432 79231683
Nail injury 13.26 9.72 18 501255 610 79242505
Strongyloidiasis 13.25 9.72 4 501269 3894 79239221
Schizophrenia 13.24 9.72 51 501222 15389 79227726
Defaecation disorder 13.17 9.72 19 501254 682 79242433
Troponin T increased 13.14 9.72 3 501270 3519 79239596
Toothache 13.07 9.72 187 501086 19783 79223332
Pericardial effusion 13.06 9.72 208 501065 46029 79197086
Enterocolitis 13.06 9.72 47 501226 14465 79228650
Lymph gland infection 12.98 9.72 17 501256 556 79242559
Skin injury 12.98 9.72 49 501224 3357 79239758
Lymphopenia 12.96 9.72 126 501147 30431 79212684
Device breakage 12.95 9.72 30 501243 10645 79232470
Transaminases increased 12.93 9.72 238 501035 51505 79191610
Alanine aminotransferase increased 12.91 9.72 864 500409 161706 79081409
Kidney infection 12.89 9.72 201 501072 21650 79221465
Osteopenia 12.84 9.72 174 501099 18190 79224925
Mood altered 12.84 9.72 63 501210 17784 79225331
Alcohol abuse 12.83 9.72 9 501264 5354 79237761
Obstructive airways disorder 12.81 9.72 131 501142 31328 79211787
Ventricular extrasystoles 12.80 9.72 72 501201 19632 79223483
Memory impairment 12.74 9.72 573 500700 111161 79131954
Upper respiratory tract infection 12.74 9.72 698 500575 90470 79152645
Investigation abnormal 12.69 9.72 35 501238 2031 79241084
Road traffic accident 12.68 9.72 362 500911 43302 79199813
Pneumonia aspiration 12.68 9.72 322 500951 66645 79176470
Oesophageal fibrosis 12.63 9.72 10 501263 176 79242939
Iodine allergy 12.57 9.72 17 501256 574 79242541
Hepatitis C 12.56 9.72 36 501237 11889 79231226
Insomnia 12.55 9.72 1349 499924 243821 78999294
Extra dose administered 12.50 9.72 21 501252 8394 79234721
Chills 12.49 9.72 853 500420 159381 79083734
Tooth disorder 12.45 9.72 233 501040 26000 79217115
Lip blister 12.42 9.72 42 501231 2725 79240390
Product administered to patient of inappropriate age 12.41 9.72 10 501263 5543 79237572
Therapy change 12.40 9.72 17 501256 7382 79235733
Device dislocation 12.36 9.72 104 501169 25866 79217249
Sleep disorder due to a general medical condition 12.35 9.72 47 501226 14230 79228885
Immunosuppression 12.35 9.72 129 501144 12674 79230441
Head injury 12.34 9.72 163 501110 37206 79205909
Breast abscess 12.33 9.72 28 501245 1438 79241677
Graft versus host disease in skin 12.29 9.72 12 501261 6061 79237054
Cross sensitivity reaction 12.28 9.72 4 501269 3708 79239407
Acute graft versus host disease in intestine 12.28 9.72 5 501268 4036 79239079
Coronary artery bypass 12.24 9.72 12 501261 6050 79237065
Ketoacidosis 12.23 9.72 19 501254 7835 79235280
Arthritis bacterial 12.21 9.72 99 501174 9067 79234048
Acute pulmonary oedema 12.21 9.72 47 501226 14183 79228932
Salivary hypersecretion 12.19 9.72 47 501226 14177 79228938
Small for dates baby 12.17 9.72 15 501258 461 79242654
Blood loss anaemia 12.16 9.72 53 501220 15445 79227670
Benign ovarian tumour 12.14 9.72 13 501260 342 79242773
Inadequate analgesia 12.13 9.72 7 501266 4622 79238493
Skin toxicity 12.12 9.72 21 501252 8293 79234822
Embolism 12.11 9.72 46 501227 13936 79229179
Bone density increased 12.11 9.72 20 501253 809 79242306
Seronegative arthritis 12.10 9.72 60 501213 4632 79238483
Renal cancer 12.09 9.72 38 501235 12188 79230927
Persecutory delusion 12.06 9.72 8 501265 4901 79238214
Laryngospasm 12.05 9.72 5 501268 3992 79239123
Catheter management 12.03 9.72 4 501269 3659 79239456
Myofascial pain syndrome 12.01 9.72 34 501239 2003 79241112
Personality change 12.01 9.72 29 501244 10141 79232974
Mass 11.99 9.72 165 501108 17307 79225808
Hypomania 11.99 9.72 18 501255 7526 79235589
Cholestasis of pregnancy 11.96 9.72 22 501251 971 79242144
Genital haemorrhage 11.93 9.72 13 501260 6242 79236873
Drug dose omission by device 11.91 9.72 13 501260 6237 79236878
Mesothelioma 11.87 9.72 13 501260 351 79242764
Sensitivity to weather change 11.87 9.72 89 501184 7958 79235157
Spondylitis 11.85 9.72 60 501213 4671 79238444
Pneumonia bacterial 11.84 9.72 72 501201 19259 79223856
Renal tubular disorder 11.81 9.72 14 501259 6472 79236643
Hypophosphataemia 11.76 9.72 75 501198 19838 79223277
Skin ulcer haemorrhage 11.75 9.72 16 501257 544 79242571
Hypertonia 11.74 9.72 17 501256 7215 79235900
Hypoventilation 11.71 9.72 17 501256 7207 79235908
Peritoneal dialysis complication 11.71 9.72 37 501236 2317 79240798
Pseudomembranous colitis 11.61 9.72 10 501263 5364 79237751
Ataxia 11.59 9.72 101 501172 24938 79218177
Rash pruritic 11.56 9.72 556 500717 71073 79172042
Lower gastrointestinal haemorrhage 11.55 9.72 57 501216 16068 79227047
Anal fistula 11.52 9.72 79 501194 6865 79236250
Photophobia 11.42 9.72 187 501086 20341 79222774
COVID-19 pneumonia 11.39 9.72 121 501152 28728 79214387
Cartilage injury 11.38 9.72 28 501245 1515 79241600
Congestive cardiomyopathy 11.38 9.72 37 501236 11743 79231372
Abortion missed 11.35 9.72 25 501248 1258 79241857
Injection site urticaria 11.33 9.72 127 501146 12699 79230416
Hepatitis E antibody positive 11.32 9.72 11 501262 257 79242858
Amyloid arthropathy 11.31 9.72 16 501257 564 79242551
Complication of device insertion 11.25 9.72 14 501259 6336 79236779
Euglycaemic diabetic ketoacidosis 11.20 9.72 16 501257 6828 79236287
Bone cyst 11.17 9.72 47 501226 3386 79239729
Chondropathy 11.16 9.72 38 501235 2474 79240641
Liver transplant 11.15 9.72 7 501266 4416 79238699
Vein disorder 11.13 9.72 63 501210 5119 79237996
Product dose omission issue 11.12 9.72 1374 499899 246163 78996952
Swollen joint count 11.12 9.72 24 501249 1191 79241924
Cholecystitis chronic 11.11 9.72 29 501244 9877 79233238
Injection site haemorrhage 11.06 9.72 241 501032 27629 79215486
Bronchial secretion retention 11.05 9.72 6 501267 4098 79239017
Pulmonary toxicity 11.02 9.72 127 501146 12787 79230328
Faecal calprotectin increased 11.02 9.72 66 501207 5475 79237640
Arthropod bite 11.02 9.72 91 501182 8380 79234735
Vacuum extractor delivery 11.01 9.72 8 501265 123 79242992
Psychomotor skills impaired 11.01 9.72 10 501263 5227 79237888
Macular degeneration 10.98 9.72 114 501159 11182 79231933
Angina unstable 10.95 9.72 60 501213 16467 79226648
Mitochondrial toxicity 10.95 9.72 3 501270 3111 79240004
Metabolic disorder 10.94 9.72 26 501247 9144 79233971
Pancreatic steatosis 10.92 9.72 23 501250 1122 79241993
Tendon disorder 10.90 9.72 80 501193 7106 79236009
Vascular purpura 10.86 9.72 3 501270 3095 79240020
Stress at work 10.84 9.72 23 501250 1128 79241987
Excessive cerumen production 10.83 9.72 18 501255 732 79242383
Bacterial sepsis 10.81 9.72 22 501251 8176 79234939
Infusion site pain 10.81 9.72 49 501224 14127 79228988
Vascular rupture 10.80 9.72 29 501244 1656 79241459
Diabetes mellitus inadequate control 10.74 9.72 99 501174 24165 79218950
Eating disorder 10.72 9.72 81 501192 20616 79222499
Red blood cell count decreased 10.71 9.72 453 500820 57060 79186055
Skin graft failure 10.71 9.72 10 501263 222 79242893
Long QT syndrome 10.69 9.72 13 501260 5942 79237173
Abortion incomplete 10.68 9.72 3 501270 3061 79240054
Limb injury 10.67 9.72 252 501021 29276 79213839
Palmoplantar keratoderma 10.65 9.72 5 501268 3711 79239404
Post-traumatic stress disorder 10.64 9.72 9 501264 4872 79238243
Carotid artery thrombosis 10.62 9.72 3 501270 3050 79240065
Joint space narrowing 10.60 9.72 17 501256 671 79242444
Anal skin tags 10.57 9.72 14 501259 463 79242652
Thirst 10.55 9.72 71 501202 18548 79224567
Osteonecrosis 10.50 9.72 135 501138 30960 79212155
Mycobacterium tuberculosis complex test positive 10.50 9.72 40 501233 2752 79240363
Hernia 10.48 9.72 158 501115 16901 79226214
Nail pitting 10.46 9.72 13 501260 403 79242712
Immunosuppressant drug level increased 10.45 9.72 26 501247 9001 79234114
Hepatitis B 10.45 9.72 23 501250 8309 79234806
Product label confusion 10.44 9.72 28 501245 1598 79241517
Human herpesvirus 6 infection 10.42 9.72 11 501262 5359 79237756
Bundle branch block right 10.42 9.72 36 501237 11215 79231900
Dry eye 10.40 9.72 305 500968 36626 79206489
Hepatitis E virus test positive 10.38 9.72 11 501262 286 79242829
Psychiatric decompensation 10.37 9.72 6 501267 3957 79239158
Device occlusion 10.30 9.72 39 501234 11827 79231288
Urinary incontinence 10.27 9.72 188 501085 40721 79202394
Immune effector cell-associated neurotoxicity syndrome 10.25 9.72 13 501260 5835 79237280
SARS-CoV-2 test negative 10.24 9.72 25 501248 1346 79241769
Sensitisation 10.22 9.72 4 501269 3307 79239808
Lip and/or oral cavity cancer 10.20 9.72 22 501251 1091 79242024
Foetal hypokinesia 10.17 9.72 12 501261 352 79242763
Blood lactate dehydrogenase increased 10.15 9.72 179 501094 38991 79204124
Thiopurine methyltransferase decreased 10.12 9.72 12 501261 354 79242761
Hypotonia 10.11 9.72 44 501229 12826 79230289
Blood potassium decreased 10.10 9.72 219 501054 46293 79196822
Metabolic encephalopathy 10.09 9.72 27 501246 9120 79233995
Liver abscess 10.06 9.72 14 501259 6040 79237075
Complication of device removal 10.02 9.72 6 501267 3883 79239232
Pancreatic duct stenosis 10.01 9.72 10 501263 242 79242873
Decreased insulin requirement 10.00 9.72 8 501265 143 79242972
Umbilical hernia 10.00 9.72 67 501206 5778 79237337
Palindromic rheumatism 9.98 9.72 13 501260 423 79242692
Accidental exposure to product by child 9.95 9.72 3 501270 2923 79240192
Breast cancer stage III 9.95 9.72 100 501173 9726 79233389
Functional gastrointestinal disorder 9.94 9.72 10 501263 4980 79238135
Skin neoplasm excision 9.91 9.72 21 501252 1029 79242086
Brain injury 9.90 9.72 38 501235 11479 79231636
Cerebral haematoma 9.90 9.72 22 501251 7920 79235195
Bundle branch block left 9.89 9.72 38 501235 11475 79231640
Brain herniation 9.86 9.72 20 501253 7443 79235672
Neurologic neglect syndrome 9.85 9.72 3 501270 2904 79240211
Pulmonary function test abnormal 9.85 9.72 7 501266 4137 79238978
Vascular insufficiency 9.84 9.72 14 501259 496 79242619
Cell death 9.84 9.72 9 501264 4690 79238425
Multiple sclerosis 9.82 9.72 91 501182 22191 79220924
Feeling hot 9.82 9.72 293 500980 59441 79183674
Crying 9.78 9.72 95 501178 22948 79220167
Postpartum haemorrhage 9.77 9.72 27 501246 1568 79241547
Impaired work ability 9.76 9.72 176 501097 19505 79223610
Epstein-Barr virus associated lymphoproliferative disorder 9.75 9.72 5 501268 3527 79239588
Concomitant disease aggravated 9.75 9.72 46 501227 13121 79229994
Laryngeal oedema 9.74 9.72 23 501250 8106 79235009
Somnambulism 9.74 9.72 13 501260 5708 79237407
Thinking abnormal 9.73 9.72 46 501227 13115 79230000
Type I hypersensitivity 9.73 9.72 8 501265 4390 79238725

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Burn injury indication 48333001
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Diaper rash indication 91487003
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Minor Bacterial Skin Infections indication
Paronychia off-label use 71906005 DOID:13117
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Anxiety contraindication 48694002
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Benign prostatic hyperplasia contraindication 266569009
Hemochromatosis contraindication 399187006 DOID:2352
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.25%;81.35%;15% VUSION MYLAN N021026 Feb. 16, 2006 RX OINTMENT TOPICAL 8147852 March 30, 2028 USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
SOI2LOH54Z UNII
4019034 VUID
N0000147305 NUI
D01170 KEGG_DRUG
4017643 VANDF
4019034 VANDF
4019036 VANDF
C0043491 UMLSCUI
CHEBI:36560 CHEBI
CHEMBL3988900 ChEMBL_ID
14806 PUBCHEM_CID
DB09321 DRUGBANK_ID
D015034 MESH_DESCRIPTOR_UI
11423 RXNORM
5049 MMSL
5709 MMSL
001922 NDDF
398971002 SNOMEDCT_US
42841002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 10 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 60 mg TOPICAL OTC monograph not final 7 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 120 mg TOPICAL OTC monograph not final 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0194 PASTE 40 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC MONOGRAPH FINAL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0324 OINTMENT 16 g TOPICAL OTC MONOGRAPH FINAL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0557 CREAM 16 g TOPICAL export only 11 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC monograph final 11 sections
CALENDULA DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2189 CREAM 12 g TOPICAL OTC monograph final 8 sections
WHITE MALLOW DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2207 CREAM 14 g TOPICAL OTC monograph final 8 sections
ZINC OXIDE HUMAN OTC DRUG LABEL 1 0168-0062 OINTMENT 200 mg TOPICAL OTC monograph final 9 sections
Dr. Smiths Rash and Skin HUMAN OTC DRUG LABEL 1 0178-0370 OINTMENT 10 g TOPICAL OTC monograph not final 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 25 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 25 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 25 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 25 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 25 mg ORAL Unapproved drug other 11 sections