calcium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4239 471-34-1

Description:

MoleculeDescription

Synonyms:

  • calcium carbonate
  • carbonic acid calcium salt
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
  • Molecular weight: 100.09
  • Formula: CCaO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 2000 FDA MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1266.98 11.23 328 967398 145345 62375951
Toxicity to various agents 654.03 11.23 1782 965944 245468 62275828
Myocardial infarction 602.48 11.23 3064 964662 96829 62424467
Drug abuse 590.09 11.23 185 967541 72333 62448963
Coronary artery disease 470.58 11.23 1318 966408 31059 62490237
Cerebrovascular accident 433.55 11.23 2977 964749 105047 62416249
Pemphigus 399.85 11.23 4422 963304 179304 62341992
Off label use 382.50 11.23 7619 960107 666843 61854453
Febrile neutropenia 382.40 11.23 767 966959 117682 62403614
Device expulsion 376.24 11.23 45 967681 34877 62486419
Acute myocardial infarction 370.98 11.23 1206 966520 30918 62490378
Systemic lupus erythematosus 361.23 11.23 4814 962912 204104 62317192
Cardiac failure congestive 355.37 11.23 2521 965205 89912 62431384
Glossodynia 320.50 11.23 4149 963577 174727 62346569
Intentional overdose 318.17 11.23 397 967329 73755 62447541
Drug ineffective 307.73 11.23 12921 954805 1031844 61489452
Death 295.04 11.23 3977 963749 370404 62150892
Malignant neoplasm progression 276.09 11.23 519 967207 81602 62439694
Suicide attempt 252.19 11.23 335 967391 60583 62460713
Abdominal discomfort 240.96 11.23 6500 961226 314385 62206911
Gastrointestinal haemorrhage 240.69 11.23 2085 965641 79091 62442205
Hand deformity 212.94 11.23 3515 964211 155942 62365354
Arthropathy 210.88 11.23 4873 962853 229919 62291377
Maternal exposure during pregnancy 208.17 11.23 4601 963125 215461 62305835
Disease progression 197.36 11.23 1081 966645 121677 62399619
Milk-alkali syndrome 188.15 11.23 131 967595 697 62520599
Transient ischaemic attack 187.65 11.23 1099 966627 36654 62484642
Product use in unapproved indication 184.37 11.23 1791 965935 177289 62344007
Wound 183.50 11.23 3502 964224 159761 62361535
Overdose 172.81 11.23 1036 966690 114042 62407254
Drug hypersensitivity 165.98 11.23 3541 964185 307146 62214150
Intentional self-injury 164.89 11.23 93 967633 25594 62495702
Alopecia 151.48 11.23 6439 961287 331097 62190199
Coronary arterial stent insertion 145.42 11.23 197 967529 2632 62518664
Angina unstable 141.89 11.23 326 967400 6769 62514527
Haemoglobin decreased 135.62 11.23 3036 964690 142449 62378847
No adverse event 135.36 11.23 266 967460 41139 62480157
Drug reaction with eosinophilia and systemic symptoms 133.09 11.23 193 967533 33643 62487653
Drug dependence 126.42 11.23 112 967614 24371 62496925
Rheumatoid arthritis 125.75 11.23 4894 962832 248925 62272371
Sopor 121.08 11.23 96 967630 22068 62499228
Pericarditis 120.49 11.23 2739 964987 128840 62392456
Plasma cell myeloma 116.37 11.23 941 966785 34964 62486332
Coronary artery bypass 114.30 11.23 160 967566 2209 62519087
Neutropenia 113.84 11.23 1928 965798 173077 62348219
Discomfort 112.70 11.23 3345 964381 164029 62357267
Angina pectoris 112.41 11.23 815 966911 29263 62492033
Intentional product misuse 110.65 11.23 514 967212 60403 62460893
Drug resistance 107.85 11.23 114 967612 22819 62498477
Anti-cyclic citrullinated peptide antibody positive 106.67 11.23 2420 965306 113792 62407504
Poisoning deliberate 105.96 11.23 21 967705 11197 62510099
Aspirin-exacerbated respiratory disease 104.96 11.23 96 967630 799 62520497
Pyrexia 104.20 11.23 5988 961738 464490 62056806
Drug ineffective for unapproved indication 103.61 11.23 228 967498 33835 62487461
Suicidal ideation 100.64 11.23 549 967177 61872 62459424
Coronary artery occlusion 99.54 11.23 313 967413 7878 62513418
Electrocardiogram QT prolonged 98.52 11.23 519 967207 59011 62462285
Wrong technique in product usage process 97.40 11.23 554 967172 61786 62459510
Respiratory arrest 97.26 11.23 221 967505 32424 62488872
Accidental exposure to product 96.73 11.23 168 967558 27237 62494059
Neoplasm progression 93.54 11.23 266 967460 36162 62485134
Drug withdrawal syndrome 92.13 11.23 171 967555 27023 62494273
Myelosuppression 90.50 11.23 138 967588 23565 62497731
Multiple sclerosis relapse 89.85 11.23 406 967320 48072 62473224
Cytomegalovirus infection 88.98 11.23 113 967613 20839 62500457
Swelling 83.31 11.23 5059 962667 270319 62250977
Device dislocation 83.28 11.23 166 967560 25539 62495757
Synovitis 82.38 11.23 3560 964166 183358 62337938
Somnolence 81.73 11.23 2085 965641 176600 62344696
Serotonin syndrome 81.59 11.23 199 967527 28483 62492813
Respiratory depression 80.62 11.23 55 967671 13660 62507636
Cardio-respiratory arrest 79.20 11.23 561 967165 59398 62461898
Hospitalisation 78.44 11.23 873 966853 84208 62437088
Device difficult to use 76.99 11.23 50 967676 12746 62508550
Urticaria 76.81 11.23 1931 965795 163871 62357425
Poisoning 76.53 11.23 58 967668 13642 62507654
Haematotoxicity 76.10 11.23 24 967702 9352 62511944
Coronary artery stenosis 75.79 11.23 200 967526 4544 62516752
Thrombosis in device 75.47 11.23 151 967575 2839 62518457
Exposure during pregnancy 74.79 11.23 2990 964736 152557 62368739
Sedation 74.36 11.23 321 967405 38488 62482808
Palmar-plantar erythrodysaesthesia syndrome 74.24 11.23 149 967577 22866 62498430
Helicobacter infection 73.00 11.23 1892 965834 90893 62430403
Myocardial ischaemia 72.30 11.23 387 967339 12472 62508824
Atrial fibrillation 71.56 11.23 2305 965421 114331 62406965
Full blood count decreased 71.22 11.23 657 967069 25367 62495929
Coma 69.89 11.23 635 967091 63729 62457567
Fall 69.41 11.23 6911 960815 385423 62135873
Duodenal ulcer 67.94 11.23 266 967460 7490 62513806
Labelled drug-drug interaction medication error 67.84 11.23 392 967334 13007 62508289
Tachycardia 67.30 11.23 1332 966394 116824 62404472
Cholestasis 67.02 11.23 227 967499 29207 62492089
Headache 65.85 11.23 8552 959174 624689 61896607
Unintentional medical device removal 65.57 11.23 8 967718 6107 62515189
Sickle cell anaemia with crisis 63.64 11.23 219 967507 5784 62515512
Anaphylactic shock 63.34 11.23 169 967557 23464 62497832
Neuroleptic malignant syndrome 62.42 11.23 55 967671 12001 62509295
Gastric ulcer 61.87 11.23 599 967127 23438 62497858
Duodenal ulcer perforation 61.69 11.23 1754 965972 85455 62435841
Pain 61.27 11.23 12478 955248 728150 61793146
Vascular stent thrombosis 61.14 11.23 75 967651 902 62520394
Upper gastrointestinal haemorrhage 61.04 11.23 494 967232 18358 62502938
Exposure to toxic agent 60.67 11.23 7 967719 5580 62515716
Hepatocellular injury 59.77 11.23 215 967511 27166 62494130
Acute myeloid leukaemia 58.82 11.23 107 967619 17040 62504256
Metastases to liver 58.23 11.23 176 967550 23463 62497833
Metastases to bone 58.10 11.23 148 967578 20871 62500425
Therapeutic product effect incomplete 58.02 11.23 1456 966270 123600 62397696
Premature delivery 57.36 11.23 710 967016 29571 62491725
Vascular stent stenosis 56.59 11.23 55 967671 498 62520798
Arteriosclerosis coronary artery 55.52 11.23 264 967462 8109 62513187
Post transplant lymphoproliferative disorder 55.40 11.23 6 967720 5025 62516271
Anaphylactic reaction 55.24 11.23 693 967033 65407 62455889
Complication of device insertion 55.22 11.23 23 967703 7541 62513755
Drug use disorder 54.74 11.23 6 967720 4978 62516318
Hepatic failure 54.54 11.23 319 967407 35337 62485959
Lymphocyte count decreased 54.52 11.23 256 967470 30001 62491295
Respiratory disorder 54.42 11.23 360 967366 38722 62482574
Lacunar infarction 54.16 11.23 140 967586 3140 62518156
Nausea 53.80 11.23 11866 955860 842605 61678691
Product quality issue 53.74 11.23 323 967403 35542 62485754
Leukopenia 53.68 11.23 841 966885 76449 62444847
Coronary artery thrombosis 53.58 11.23 76 967650 1063 62520233
Rheumatoid factor positive 53.58 11.23 1675 966051 82731 62438565
Drug interaction 53.55 11.23 2900 964826 226231 62295065
Mucosal inflammation 53.14 11.23 458 967268 46470 62474826
Fatigue 52.64 11.23 14738 952988 873290 61648006
Febrile bone marrow aplasia 52.32 11.23 23 967703 7302 62513994
Device use error 51.93 11.23 12 967714 5749 62515547
Breast cancer stage I 51.84 11.23 20 967706 6869 62514427
Hip arthroplasty 51.74 11.23 1017 966709 46629 62474667
Carotid artery stenosis 51.69 11.23 185 967541 4985 62516311
Infective pulmonary exacerbation of cystic fibrosis 50.98 11.23 36 967690 8781 62512515
Knee arthroplasty 50.71 11.23 1132 966594 53074 62468222
Joint swelling 50.60 11.23 5720 962006 321946 62199350
Deafness transitory 50.34 11.23 100 967626 1870 62519426
Toxic skin eruption 50.18 11.23 74 967652 12811 62508485
Melaena 50.00 11.23 694 967032 29671 62491625
Ascites 50.00 11.23 389 967337 40339 62480957
Asthma 49.70 11.23 1522 966204 126039 62395257
Infusion related reaction 49.66 11.23 4367 963359 241154 62280142
Contusion 49.22 11.23 2777 964949 147267 62374029
Mydriasis 49.21 11.23 66 967660 11890 62509406
Chest pain 48.88 11.23 3874 963852 212085 62309211
Hepatic function abnormal 48.81 11.23 348 967378 36794 62484502
Thrombosis 48.78 11.23 1313 966413 63442 62457854
Haemophagocytic lymphohistiocytosis 48.67 11.23 54 967672 10573 62510723
Anxiety 48.50 11.23 2766 964960 214775 62306521
Recalled product 48.26 11.23 81 967645 1322 62519974
Femur fracture 47.98 11.23 899 966827 40857 62480439
Withdrawal syndrome 47.76 11.23 151 967575 19846 62501450
Temperature regulation disorder 47.50 11.23 17 967709 6115 62515181
Contraindicated product administered 47.27 11.23 3892 963834 213756 62307540
Encephalopathy 46.88 11.23 370 967356 38250 62483046
Device issue 46.60 11.23 195 967531 23586 62497710
Hepatic enzyme increased 46.53 11.23 3634 964092 198694 62322602
Posterior reversible encephalopathy syndrome 46.51 11.23 124 967602 17221 62504075
Insomnia 45.81 11.23 2749 964977 212503 62308793
Neurotoxicity 45.15 11.23 122 967604 16868 62504428
Dystonia 44.97 11.23 89 967637 13730 62507566
Cataract 44.75 11.23 1163 966563 55890 62465406
Therapy partial responder 44.72 11.23 58 967668 10600 62510696
Thrombotic microangiopathy 43.77 11.23 58 967668 10503 62510793
Uterine perforation 43.57 11.23 26 967700 6937 62514359
Agitation 43.28 11.23 645 967081 59112 62462184
Metastases to central nervous system 42.99 11.23 84 967642 13021 62508275
Retroperitoneal haemorrhage 42.75 11.23 116 967610 2681 62518615
Multiple-drug resistance 42.38 11.23 13 967713 5157 62516139
Incorrect route of product administration 42.31 11.23 245 967481 27207 62494089
Seizure 41.82 11.23 1625 966101 131009 62390287
Depressed level of consciousness 41.27 11.23 681 967045 61397 62459899
Irritability 41.14 11.23 298 967428 31396 62489900
Gastric ulcer haemorrhage 41.12 11.23 166 967560 4742 62516554
Flushing 41.09 11.23 852 966874 74235 62447061
Acute graft versus host disease in skin 41.03 11.23 3 967723 3449 62517847
Cytokine release syndrome 40.96 11.23 99 967627 14215 62507081
Coronary artery restenosis 40.82 11.23 39 967687 345 62520951
Acute graft versus host disease 40.36 11.23 9 967717 4419 62516877
Complication of device removal 40.26 11.23 14 967712 5128 62516168
Akathisia 40.23 11.23 48 967678 9098 62512198
Graft versus host disease 39.92 11.23 27 967699 6736 62514560
Gastritis erosive 39.75 11.23 190 967536 5849 62515447
Hypoxia 39.72 11.23 656 967070 59136 62462160
Arteriosclerosis 38.91 11.23 275 967451 9791 62511505
Red blood cell sedimentation rate abnormal 38.84 11.23 467 967259 19315 62501981
Bone marrow failure 38.70 11.23 274 967452 29016 62492280
Vomiting 38.58 11.23 7735 959991 551882 61969414
Graft versus host disease in gastrointestinal tract 38.00 11.23 3 967723 3238 62518058
Shunt stenosis 37.99 11.23 44 967682 496 62520800
Epstein-Barr virus infection 37.87 11.23 40 967686 8010 62513286
Agranulocytosis 37.84 11.23 226 967500 24908 62496388
Body temperature increased 37.78 11.23 373 967353 36819 62484477
Haematocrit decreased 37.57 11.23 824 966902 38516 62482780
Mitral valve incompetence 37.36 11.23 460 967266 19134 62502162
Neutrophil count decreased 37.09 11.23 620 967106 55786 62465510
Paradoxical drug reaction 36.73 11.23 9 967717 4143 62517153
Psoriatic arthropathy 36.55 11.23 1726 966000 89794 62431502
Thrombocytopenia 36.44 11.23 1907 965819 149250 62372046
Multiple organ dysfunction syndrome 36.28 11.23 627 967099 56125 62465171
Device breakage 36.14 11.23 76 967650 11466 62509830
Genital haemorrhage 36.13 11.23 35 967691 7297 62513999
Blood pressure systolic increased 35.97 11.23 962 966764 46435 62474861
Acute generalised exanthematous pustulosis 35.67 11.23 72 967654 11027 62510269
Erythema 35.55 11.23 2255 965471 173496 62347800
Migraine 35.07 11.23 1255 966471 102091 62419205
Cardiac arrest 34.39 11.23 1111 966615 91434 62429862
Muscle spasticity 33.86 11.23 194 967532 21600 62499696
Metastases to lung 33.55 11.23 92 967634 12658 62508638
Exposure via ingestion 33.26 11.23 3 967723 2906 62518390
Carotid artery thrombosis 33.25 11.23 106 967620 2688 62518608
Graft versus host disease in skin 33.20 11.23 3 967723 2902 62518394
Osteoarthritis 32.50 11.23 1771 965955 93572 62427724
Bronchopulmonary aspergillosis 32.27 11.23 51 967675 8584 62512712
Transplant dysfunction 32.20 11.23 17 967709 4855 62516441
Interstitial lung disease 31.97 11.23 709 967017 61199 62460097
Status epilepticus 31.68 11.23 122 967604 15111 62506185
Hyperprolactinaemia 31.62 11.23 10 967716 3890 62517406
Human herpesvirus 6 infection 31.39 11.23 4 967722 2953 62518343
Acute hepatic failure 31.32 11.23 158 967568 18169 62503127
Pathogen resistance 31.00 11.23 31 967695 6367 62514929
Vascular graft 30.96 11.23 50 967676 789 62520507
Food allergy 30.95 11.23 81 967645 11320 62509976
Second primary malignancy 30.65 11.23 46 967680 7907 62513389
Gastrointestinal toxicity 30.59 11.23 44 967682 7697 62513599
Haemorrhage intracranial 30.51 11.23 326 967400 13093 62508203
Faeces discoloured 30.46 11.23 423 967303 18086 62503210
Cardiotoxicity 30.44 11.23 51 967675 8387 62512909
Product preparation error 30.11 11.23 29 967697 6063 62515233
Blood pressure diastolic decreased 29.69 11.23 499 967227 22207 62499089
Acute coronary syndrome 29.42 11.23 259 967467 9867 62511429
Disturbance in social behaviour 29.38 11.23 12 967714 3981 62517315
Shunt occlusion 29.28 11.23 43 967683 622 62520674
Cardiovascular disorder 29.25 11.23 292 967434 11520 62509776
Cytomegalovirus viraemia 28.97 11.23 26 967700 5623 62515673
Ear pain 28.94 11.23 382 967344 35736 62485560
Chronic graft versus host disease 28.90 11.23 6 967720 3096 62518200
Amenorrhoea 28.82 11.23 68 967658 9846 62511450
Systemic infection 28.80 11.23 144 967582 4516 62516780
Ventricular hypertrophy 28.62 11.23 116 967610 3320 62517976
Blood urea increased 28.62 11.23 563 967163 25816 62495480
Heart rate decreased 28.60 11.23 903 966823 44657 62476639
Live birth 28.48 11.23 549 967177 25081 62496215
Disseminated intravascular coagulation 28.31 11.23 172 967554 18879 62502417
Altered state of consciousness 28.22 11.23 247 967479 24983 62496313
Anosognosia 28.14 11.23 7 967719 3189 62518107
Mucormycosis 27.92 11.23 5 967721 2866 62518430
Immune reconstitution inflammatory syndrome 27.77 11.23 31 967695 6053 62515243
Disability assessment scale score increased 27.61 11.23 110 967616 3123 62518173
Hyperhidrosis 27.61 11.23 1352 966374 106484 62414812
Peripheral arterial occlusive disease 27.52 11.23 132 967594 4069 62517227
Adenovirus infection 27.49 11.23 10 967716 3561 62517735
Aspergillus infection 27.31 11.23 51 967675 8042 62513254
Abortion incomplete 27.29 11.23 7 967719 3124 62518172
Aortic valve stenosis 27.18 11.23 111 967615 3188 62518108
Duodenal ulcer haemorrhage 27.03 11.23 91 967635 2376 62518920
Hypocalcaemia 26.80 11.23 653 967073 31060 62490236
Lower gastrointestinal haemorrhage 26.77 11.23 209 967517 7681 62513615
Breast cancer female 26.68 11.23 111 967615 13448 62507848
Tumour lysis syndrome 26.66 11.23 61 967665 8929 62512367
Diverticulum 26.65 11.23 290 967436 11701 62509595
Arthralgia 26.52 11.23 9368 958358 560342 61960954
Inappropriate schedule of product administration 26.51 11.23 1304 966422 102661 62418635
Aplasia 26.51 11.23 16 967710 4243 62517053
Embedded device 26.40 11.23 10 967716 3473 62517823
Pruritus 26.34 11.23 4981 962745 356472 62164824
Brain oedema 26.23 11.23 119 967607 14076 62507220
Neurologic neglect syndrome 26.05 11.23 96 967630 2625 62518671
Pseudomonas infection 25.85 11.23 86 967640 11127 62510169
Eosinophilia 25.80 11.23 222 967504 22534 62498762
Pericardial haemorrhage 25.60 11.23 68 967658 1551 62519745
Hepatitis B reactivation 25.51 11.23 8 967718 3129 62518167
Rhabdomyolysis 25.50 11.23 863 966863 43088 62478208
Extrapyramidal disorder 25.37 11.23 110 967616 13174 62508122
Disturbance in attention 25.36 11.23 419 967307 37770 62483526
Premature labour 25.35 11.23 297 967429 12207 62509089
Spinal stenosis 25.34 11.23 343 967383 14582 62506714
Gastritis 25.20 11.23 746 966980 36557 62484739
Pulmonary toxicity 25.04 11.23 68 967658 9387 62511909
Sexual dysfunction 24.94 11.23 18 967708 4341 62516955
Multiple fractures 24.82 11.23 220 967506 8398 62512898
Pregnancy with contraceptive device 24.81 11.23 21 967705 4673 62516623
Substance abuse 24.80 11.23 22 967704 4785 62516511
Hypercalcaemia 24.79 11.23 586 967140 27736 62493560
Caesarean section 24.78 11.23 381 967345 16651 62504645
Adjustment disorder 24.67 11.23 105 967621 3073 62518223
Device malfunction 24.60 11.23 165 967561 17692 62503604
Nasopharyngitis 24.46 11.23 4318 963408 249939 62271357
Polyneuropathy 24.24 11.23 127 967599 14462 62506834
Skin toxicity 23.82 11.23 22 967704 4692 62516604
Metastases to lymph nodes 23.68 11.23 56 967670 8102 62513194
Sepsis 23.66 11.23 2010 965716 151113 62370183
Juvenile idiopathic arthritis 23.62 11.23 107 967619 3219 62518077
Haematochezia 23.59 11.23 1020 966706 52524 62468772
Bradyphrenia 23.55 11.23 44 967682 6936 62514360
Depression 23.54 11.23 2628 965098 193864 62327432
Blood loss anaemia 23.51 11.23 225 967501 8776 62512520
Hip fracture 23.45 11.23 602 967124 28872 62492424
Hallucination, auditory 23.40 11.23 108 967618 12716 62508580
Mania 23.26 11.23 103 967623 12264 62509032
Stent placement 23.18 11.23 116 967610 3639 62517657
Mood altered 23.03 11.23 131 967595 14612 62506684
Schizoaffective disorder 22.71 11.23 13 967713 3549 62517747
Disease recurrence 22.62 11.23 296 967430 27734 62493562
Haematoma 22.62 11.23 693 967033 34127 62487169
Ischaemic cardiomyopathy 22.55 11.23 86 967640 2391 62518905
Pain in extremity 22.54 11.23 5536 962190 325950 62195346
Lymphopenia 22.51 11.23 175 967551 18152 62503144
Pelvic pain 22.28 11.23 118 967608 13401 62507895
Chronic obstructive pulmonary disease 22.28 11.23 1169 966557 61517 62459779
Breast cancer stage II 22.27 11.23 64 967662 8672 62512624
Drug level increased 22.27 11.23 230 967496 22506 62498790
Infusion site pain 22.19 11.23 158 967568 16711 62504585
Osteonecrosis of jaw 22.14 11.23 389 967337 34734 62486562
Haemorrhage 22.10 11.23 1140 966586 59882 62461414
Mood swings 22.06 11.23 175 967551 18073 62503223
Gastrointestinal pain 21.99 11.23 237 967489 9539 62511757
Electrocardiogram ST segment elevation 21.95 11.23 118 967608 3809 62517487
Hereditary angioedema 21.88 11.23 52 967674 7510 62513786
Vascular pseudoaneurysm 21.84 11.23 62 967664 1472 62519824
Unintended pregnancy 21.69 11.23 38 967688 6141 62515155
Product adhesion issue 21.59 11.23 24 967702 4695 62516601
Device related infection 21.56 11.23 240 967486 23152 62498144
Acute respiratory distress syndrome 21.47 11.23 242 967484 23292 62498004
Blood pressure fluctuation 21.46 11.23 887 966839 45430 62475866
Joint effusion 21.25 11.23 372 967354 16688 62504608
Multiple injuries 21.20 11.23 68 967658 1730 62519566
Joint laxity 21.17 11.23 84 967642 2380 62518916
Diverticulum intestinal haemorrhagic 21.17 11.23 62 967664 1499 62519797
Rash maculo-papular 21.16 11.23 350 967376 31546 62489750
Rectal haemorrhage 21.16 11.23 932 966794 48098 62473198
Cerebral haemorrhage 21.15 11.23 616 967110 30113 62491183
Cystitis haemorrhagic 21.12 11.23 19 967707 4104 62517192
Hemiplegia 20.97 11.23 226 967500 9097 62512199
Colorectal cancer 20.92 11.23 15 967711 3630 62517666
BK virus infection 20.86 11.23 12 967714 3267 62518029
Hemiparesis 20.77 11.23 483 967243 22799 62498497
Blood prolactin increased 20.65 11.23 14 967712 3489 62517807
Metabolic acidosis 20.55 11.23 526 967200 44543 62476753
Haemorrhagic stroke 20.53 11.23 155 967571 5637 62515659
Cell death 20.51 11.23 7 967719 2594 62518702
Abnormal behaviour 20.48 11.23 218 967508 21208 62500088
Hepatic cytolysis 20.42 11.23 144 967582 15263 62506033
Respiratory failure 20.39 11.23 1308 966418 100550 62420746
Pre-eclampsia 20.36 11.23 221 967505 8912 62512384
Osteoporosis 20.32 11.23 1069 966657 56269 62465027
Catatonia 20.23 11.23 23 967703 4454 62516842
Haematemesis 20.22 11.23 607 967119 29805 62491491
Hiatus hernia 20.20 11.23 451 967275 21143 62500153
Cardiac disorder 20.20 11.23 958 966768 49858 62471438
Retroperitoneal haematoma 20.16 11.23 93 967633 2820 62518476
Transplant rejection 20.14 11.23 90 967636 10690 62510606
Dermatitis acneiform 20.14 11.23 28 967698 4968 62516328
Aggression 20.14 11.23 245 967481 23253 62498043
Tooth disorder 20.09 11.23 567 967159 27590 62493706
Rib deformity 20.08 11.23 23 967703 256 62521040
Acute lymphocytic leukaemia recurrent 19.92 11.23 5 967721 2264 62519032
Nephrocalcinosis 19.89 11.23 48 967678 1030 62520266
Psoriasis 19.82 11.23 1561 966165 85396 62435900
Tardive dyskinesia 19.74 11.23 65 967661 8437 62512859
Product dose omission issue 19.55 11.23 3205 964521 231108 62290188
Urinary tract infection 19.53 11.23 4437 963289 260247 62261049
Blood pressure diastolic abnormal 19.53 11.23 321 967405 14221 62507075
Hypertransaminasaemia 19.48 11.23 45 967681 6564 62514732
Peripheral vascular disorder 19.46 11.23 158 967568 5877 62515419
Panic attack 19.45 11.23 232 967494 22099 62499197
Rheumatic fever 19.38 11.23 823 966903 42288 62479008
Dyskinesia 19.36 11.23 357 967369 31645 62489651
Coronary artery aneurysm 19.32 11.23 10 967716 27 62521269
Hepatotoxicity 19.18 11.23 424 967302 36617 62484679
Galactorrhoea 19.15 11.23 21 967705 4134 62517162
Carotid arteriosclerosis 19.08 11.23 48 967678 1058 62520238
Product substitution issue 19.06 11.23 154 967572 15842 62505454
Abnormal loss of weight 18.98 11.23 152 967574 5630 62515666
Oral allergy syndrome 18.92 11.23 12 967714 53 62521243
Pneumonia viral 18.79 11.23 60 967666 7862 62513434
Face oedema 18.77 11.23 207 967519 20005 62501291
Basal cell carcinoma 18.69 11.23 559 967167 27432 62493864
Bradypnoea 18.62 11.23 16 967710 3534 62517762
Musculoskeletal stiffness 18.58 11.23 3143 964583 181475 62339821
Aneurysm 18.55 11.23 89 967637 2744 62518552
Blood pressure increased 18.47 11.23 2778 964948 159284 62362012
Blood calcium increased 18.47 11.23 221 967505 9129 62512167
Injection site haematoma 18.45 11.23 172 967554 6660 62514636
Spinal osteoarthritis 18.42 11.23 348 967378 15838 62505458
Product use issue 18.36 11.23 3718 964008 216802 62304494
Incorrect product administration duration 18.36 11.23 102 967624 11444 62509852
Red blood cell count decreased 18.29 11.23 776 966950 39869 62481427
Bone disorder 18.28 11.23 440 967286 20886 62500410
Wrist fracture 18.28 11.23 300 967426 13287 62508009
Swollen joint count increased 18.23 11.23 697 967029 35357 62485939
Breast cancer stage IV 18.18 11.23 4 967722 1982 62519314
Tremor 18.08 11.23 1752 965974 130487 62390809
Malignant melanoma 18.07 11.23 258 967468 11098 62510198
Eating disorder 18.06 11.23 398 967328 18618 62502678
Accidental death 18.04 11.23 4 967722 1972 62519324
Restlessness 18.00 11.23 328 967398 29125 62492171
Affective disorder 17.99 11.23 42 967684 6104 62515192
Localised infection 17.99 11.23 595 967131 29615 62491681
Oedema peripheral 17.95 11.23 3216 964510 186295 62335001
Miosis 17.93 11.23 55 967671 7298 62513998
Blood pressure systolic abnormal 17.80 11.23 295 967431 13091 62508205
Arthritis 17.76 11.23 2023 965703 113898 62407398
Transaminases increased 17.73 11.23 354 967372 31013 62490283
Aortic arteriosclerosis 17.62 11.23 158 967568 6051 62515245
Rectal polyp 17.57 11.23 50 967676 1189 62520107
Klebsiella infection 17.56 11.23 69 967657 8497 62512799
Sinus node dysfunction 17.53 11.23 127 967599 4558 62516738
Cerebral ischaemia 17.48 11.23 168 967558 6560 62514736
Blood iron abnormal 17.42 11.23 20 967706 3856 62517440
Feeling hot 17.41 11.23 610 967116 49744 62471552
Epilepsy 17.30 11.23 299 967427 26766 62494530
Fracture delayed union 17.27 11.23 78 967648 2344 62518952
Arterial stenosis 17.26 11.23 32 967694 567 62520729
Bradykinesia 17.24 11.23 33 967693 5155 62516141
Dilatation atrial 17.21 11.23 68 967658 1923 62519373
Gamma-glutamyltransferase increased 17.21 11.23 391 967335 33640 62487656
Occult blood positive 17.06 11.23 105 967621 3565 62517731
Aortic stenosis 17.05 11.23 133 967593 4887 62516409
Forced expiratory volume decreased 17.04 11.23 31 967695 4937 62516359
Lung neoplasm 17.02 11.23 152 967574 5814 62515482
Sleep disorder 16.92 11.23 1044 966682 80522 62440774
Product administered to patient of inappropriate age 16.81 11.23 15 967711 3253 62518043
Coeliac disease 16.76 11.23 120 967606 12677 62508619
Diabetic ketoacidosis 16.75 11.23 216 967510 20289 62501007
Aortic valve sclerosis 16.70 11.23 48 967678 1148 62520148
Nicotine dependence 16.67 11.23 35 967691 682 62520614
Rebound effect 16.66 11.23 27 967699 4499 62516797
Device deployment issue 16.62 11.23 21 967705 3881 62517415
Product storage error 16.47 11.23 147 967579 14809 62506487
Cerebral infarction 16.46 11.23 479 967247 23414 62497882
Atrial septal defect 16.45 11.23 170 967556 6768 62514528
Post procedural haematoma 16.45 11.23 50 967676 1235 62520061
Bronchospasm 16.44 11.23 176 967550 17104 62504192
Humerus fracture 16.43 11.23 208 967518 8708 62512588
Vasoplegia syndrome 16.43 11.23 3 967723 1696 62519600
Drug dose omission by device 16.43 11.23 30 967696 4771 62516525
Hyperbilirubinaemia 16.37 11.23 103 967623 11211 62510085
Electrocardiogram ST-T change 16.29 11.23 44 967682 1014 62520282
Coronary angioplasty 16.28 11.23 13 967713 88 62521208
Hyperlipidaemia 16.24 11.23 402 967324 19169 62502127
Maternal drugs affecting foetus 16.24 11.23 136 967590 5106 62516190
Analgesic drug level increased 16.09 11.23 8 967718 2364 62518932
Accidental overdose 16.05 11.23 254 967472 23055 62498241
Shock 16.05 11.23 256 967470 23207 62498089
Aortic aneurysm 16.03 11.23 107 967619 3737 62517559
Laboratory test abnormal 16.01 11.23 530 967196 26382 62494914
Ventricular septal defect 15.99 11.23 118 967608 4260 62517036
Menstruation irregular 15.95 11.23 54 967672 6950 62514346
Metastases to meninges 15.88 11.23 10 967716 2592 62518704
Hypersensitivity myocarditis 15.87 11.23 18 967708 198 62521098
Cerebellar haemorrhage 15.79 11.23 52 967674 1342 62519954
Complication associated with device 15.72 11.23 174 967552 16804 62504492
Vascular dementia 15.72 11.23 30 967696 544 62520752
Nasal obstruction 15.68 11.23 60 967666 1671 62519625
Neck deformity 15.64 11.23 69 967657 2052 62519244
Hypophosphataemic osteomalacia 15.60 11.23 18 967708 202 62521094
Hypertension 15.52 11.23 4625 963101 274678 62246618
Intervertebral disc degeneration 15.49 11.23 331 967395 15401 62505895
Rectourethral fistula 15.43 11.23 9 967717 33 62521263
Implant site pain 15.42 11.23 9 967717 2431 62518865
Urinary retention 15.36 11.23 348 967378 29953 62491343
Coordination abnormal 15.29 11.23 295 967431 13478 62507818
Platelet aggregation increased 15.24 11.23 7 967719 13 62521283
Cerebrovascular disorder 15.21 11.23 82 967644 2650 62518646
Reye's syndrome 15.13 11.23 6 967720 6 62521290
Cross sensitivity reaction 15.11 11.23 7 967719 2155 62519141
Salivary gland calculus 15.11 11.23 16 967710 162 62521134
Hyperthermia 15.04 11.23 80 967646 9076 62512220
Ejection fraction 15.03 11.23 9 967717 2397 62518899
Chest discomfort 15.03 11.23 1457 966269 108512 62412784
Non-cardiac chest pain 15.03 11.23 154 967572 6118 62515178
Nightmare 15.01 11.23 204 967522 18990 62502306
Aspartate aminotransferase increased 15.01 11.23 1178 966548 89099 62432197
Neutropenic colitis 14.99 11.23 15 967711 3080 62518216
Musculoskeletal discomfort 14.89 11.23 369 967357 17598 62503698
Device use issue 14.86 11.23 11 967715 2619 62518677
Oesophagitis haemorrhagic 14.85 11.23 27 967699 471 62520825
Haemorrhagic transformation stroke 14.83 11.23 47 967679 1188 62520108
Sinus arrest 14.83 11.23 64 967662 1885 62519411
Peripheral ischaemia 14.81 11.23 126 967600 4752 62516544
Torsade de pointes 14.80 11.23 131 967595 13220 62508076
Vital capacity decreased 14.80 11.23 4 967722 1724 62519572
Therapy interrupted 14.73 11.23 379 967347 32076 62489220
Oculogyric crisis 14.71 11.23 4 967722 1717 62519579
Premature rupture of membranes 14.66 11.23 128 967598 4865 62516431
Heart rate irregular 14.50 11.23 446 967280 21975 62499321
Middle insomnia 14.49 11.23 123 967603 12520 62508776
Angiopathy 14.46 11.23 120 967606 4493 62516803
Calciphylaxis 14.35 11.23 88 967638 2984 62518312
Diverticulum intestinal 14.30 11.23 161 967565 6552 62514744
Cytomegalovirus infection reactivation 14.25 11.23 24 967702 3939 62517357
Crying 14.25 11.23 260 967466 23083 62498213
Myoclonus 14.15 11.23 164 967562 15704 62505592
Latent tuberculosis 14.05 11.23 78 967648 2549 62518747
Metastasis 14.05 11.23 37 967689 5160 62516136
Muscle rigidity 14.04 11.23 110 967616 11390 62509906
Carotid artery disease 14.00 11.23 56 967670 1593 62519703
Postoperative wound infection 13.88 11.23 239 967487 10686 62510610
Venoocclusive disease 13.87 11.23 7 967719 2051 62519245
Aortic valve incompetence 13.86 11.23 146 967580 5842 62515454
Lichen planopilaris 13.82 11.23 9 967717 42 62521254
Haptoglobin increased 13.82 11.23 9 967717 42 62521254
Weight decreased 13.79 11.23 4564 963162 272234 62249062
Throat clearing 13.73 11.23 73 967653 2346 62518950
Heparin-induced thrombocytopenia 13.73 11.23 118 967608 4464 62516832
Multiple use of single-use product 13.67 11.23 3 967723 1489 62519807
Infusion site erythema 13.66 11.23 113 967613 11566 62509730
Subdural haematoma 13.64 11.23 300 967426 14028 62507268
Twin pregnancy 13.50 11.23 44 967682 1129 62520167
Epstein-Barr virus associated lymphoproliferative disorder 13.44 11.23 6 967720 1888 62519408
Duodenitis 13.37 11.23 101 967625 3674 62517622
Vitello-intestinal duct remnant 13.35 11.23 9 967717 45 62521251
Vascular graft occlusion 13.29 11.23 17 967709 214 62521082
Fluid retention 13.26 11.23 759 966967 58927 62462369
Large intestine polyp 13.25 11.23 186 967540 7971 62513325
Cytopenia 13.23 11.23 113 967613 11488 62509808
Loss of employment 13.19 11.23 9 967717 2235 62519061
Malaise 13.18 11.23 5937 961789 410017 62111279
Increased tendency to bruise 13.11 11.23 230 967496 10322 62510974
Blood cholesterol increased 13.07 11.23 1631 966095 92401 62428895
Varicella zoster virus infection 13.06 11.23 13 967713 2676 62518620
Virologic failure 13.06 11.23 6 967720 1856 62519440
Platelet dysfunction 13.02 11.23 12 967714 101 62521195
Cardiac valve disease 13.00 11.23 110 967616 4142 62517154
Metabolic disorder 12.94 11.23 53 967673 6450 62514846
Crohn's disease 12.92 11.23 123 967603 4790 62516506
Embolic stroke 12.80 11.23 100 967626 3676 62517620
Erythroblast count increased 12.80 11.23 4 967722 0 62521296
Acute lung injury 12.79 11.23 4 967722 1567 62519729
HELLP syndrome 12.78 11.23 40 967686 1004 62520292
Generalised oedema 12.78 11.23 167 967559 15651 62505645
Tenderness 12.76 11.23 442 967284 22136 62499160
Self-injurious ideation 12.75 11.23 13 967713 2646 62518650
Congenital hydronephrosis 12.74 11.23 23 967703 399 62520897
Polycystic ovaries 12.73 11.23 31 967695 4440 62516856
Application site pain 12.71 11.23 28 967698 4154 62517142
Coronary artery reocclusion 12.67 11.23 8 967718 35 62521261
Psychotic symptom 12.66 11.23 4 967722 1557 62519739
Metabolic alkalosis 12.64 11.23 85 967641 2976 62518320
Dyspnoea 12.64 11.23 9582 958144 651731 61869565
Otitis media bacterial 12.61 11.23 5 967721 5 62521291
Otitis media staphylococcal 12.61 11.23 5 967721 5 62521291
Blood creatine phosphokinase MB increased 12.58 11.23 44 967682 1172 62520124
Vascular device infection 12.52 11.23 63 967663 7249 62514047
Shoulder arthroplasty 12.49 11.23 104 967622 3898 62517398
Thrombotic stroke 12.47 11.23 26 967700 504 62520792
Pneumonia fungal 12.47 11.23 42 967684 5413 62515883
Diabetes insipidus 12.40 11.23 13 967713 2612 62518684
Skin cancer 12.35 11.23 245 967481 11250 62510046
Stevens-Johnson syndrome 12.24 11.23 288 967438 24662 62496634
Pharyngeal haemorrhage 12.24 11.23 27 967699 545 62520751
Metastases to peritoneum 12.24 11.23 21 967705 3421 62517875
Device leakage 12.22 11.23 61 967665 7035 62514261
Dysphoria 12.21 11.23 37 967689 4929 62516367
Pelvic haematoma 12.20 11.23 28 967698 581 62520715
Liver function test increased 12.16 11.23 394 967332 32417 62488879
Abdominal pain 12.16 11.23 4148 963578 289308 62231988
Cardiac murmur 12.10 11.23 299 967427 14253 62507043
Psychomotor hyperactivity 12.10 11.23 104 967622 10559 62510737
Septic shock 12.10 11.23 863 966863 65766 62455530
Ileus 12.07 11.23 155 967571 14570 62506726
Eye excision 12.02 11.23 8 967718 39 62521257
Mitral valve calcification 12.00 11.23 38 967688 960 62520336
Vision blurred 11.99 11.23 1222 966504 90702 62430594
Diverticulitis 11.98 11.23 727 966999 38830 62482466
Normal newborn 11.91 11.23 186 967540 8155 62513141
Ischaemia 11.83 11.23 118 967608 4654 62516642
Feeling abnormal 11.80 11.23 2035 965691 146357 62374939
Hepatitis C 11.78 11.23 41 967685 5233 62516063
Tetany 11.78 11.23 61 967665 1940 62519356
Acute myeloid leukaemia recurrent 11.74 11.23 5 967721 1618 62519678
Arterial stent insertion 11.74 11.23 7 967719 27 62521269
Respiration abnormal 11.73 11.23 54 967672 6363 62514933
Infusion site swelling 11.67 11.23 94 967632 9676 62511620
Mitral valve stenosis 11.67 11.23 42 967684 1135 62520161
Peritoneal dialysis complication 11.64 11.23 43 967683 1177 62520119
Hypercalciuria 11.63 11.23 19 967707 303 62520993
Congenital uterine anomaly 11.59 11.23 12 967714 118 62521178
Pain in jaw 11.59 11.23 543 967183 42953 62478343
Body height decreased 11.58 11.23 217 967509 9861 62511435
Glomerular filtration rate increased 11.55 11.23 35 967691 863 62520433
Drug effective for unapproved indication 11.53 11.23 21 967705 3343 62517953
Clear cell renal cell carcinoma 11.48 11.23 49 967677 1436 62519860
Small for dates baby 11.45 11.23 97 967629 3654 62517642
Diverticulitis intestinal haemorrhagic 11.44 11.23 12 967714 120 62521176
Neoplasm recurrence 11.44 11.23 14 967712 2624 62518672
Haemarthrosis 11.44 11.23 85 967641 3076 62518220
Skin plaque 11.40 11.23 77 967649 8243 62513053
Intraventricular haemorrhage 11.38 11.23 63 967663 2057 62519239
COVID-19 11.37 11.23 1530 966196 111573 62409723
Rheumatoid factor increased 11.33 11.23 57 967669 1792 62519504
Catheter site haematoma 11.31 11.23 14 967712 170 62521126
Peritonitis bacterial 11.31 11.23 119 967607 4760 62516536
Alcohol interaction 11.30 11.23 12 967714 2397 62518899
Extraocular muscle disorder 11.29 11.23 12 967714 122 62521174
Metastases to pleura 11.28 11.23 5 967721 1580 62519716
Blood iron increased 11.25 11.23 50 967676 1492 62519804

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1437.22 12.48 4963 596103 116122 34239743
Drug abuse 1196.29 12.48 148 600918 98948 34256917
Coronary artery disease 1131.10 12.48 2539 598527 45766 34310099
Toxicity to various agents 933.91 12.48 1248 599818 199114 34156751
Completed suicide 780.93 12.48 355 600711 97813 34258052
Off label use 769.84 12.48 4163 596903 415361 33940504
Cardiac failure congestive 680.60 12.48 3037 598029 80233 34275632
Acute myocardial infarction 669.48 12.48 2240 598826 51479 34304386
Drug ineffective 653.73 12.48 4891 596175 451860 33904005
Cerebrovascular accident 422.13 12.48 2699 598367 82112 34273753
Gastrointestinal haemorrhage 419.24 12.48 2781 598285 85696 34270169
Febrile neutropenia 418.68 12.48 1099 599967 135750 34220115
Product use in unapproved indication 394.43 12.48 899 600167 116600 34239265
Gastric haemorrhage 349.73 12.48 631 600435 9630 34346235
Angina unstable 335.71 12.48 667 600399 10986 34344879
Angina pectoris 315.65 12.48 1220 599846 30143 34325722
Death 304.27 12.48 4917 596149 393132 33962733
Coronary arterial stent insertion 284.22 12.48 353 600713 3776 34352089
Coronary artery bypass 276.62 12.48 380 600686 4522 34351343
Chest pain 235.03 12.48 3265 597801 123497 34232368
Thrombosis in device 234.88 12.48 288 600778 3037 34352828
Coronary artery occlusion 216.96 12.48 540 600526 10422 34345443
Disease progression 197.63 12.48 1071 599995 107006 34248859
Drug dependence 176.71 12.48 98 600968 24119 34331746
Intentional product misuse 176.69 12.48 321 600745 45290 34310575
Pyrexia 167.13 12.48 4405 596661 328608 34027257
Myocardial ischaemia 166.88 12.48 667 600399 16741 34339124
Coronary artery stenosis 165.96 12.48 450 600616 9166 34346699
Intentional overdose 162.45 12.48 315 600751 43359 34312506
Malignant neoplasm progression 162.31 12.48 870 600196 87176 34268689
Melaena 159.51 12.48 1099 599967 34281 34321584
Suicide attempt 158.12 12.48 268 600798 38848 34317017
Drug reaction with eosinophilia and systemic symptoms 158.07 12.48 201 600865 32811 34323054
Haemorrhage 157.78 12.48 1461 599605 49909 34305956
Neutropenia 154.40 12.48 1838 599228 154940 34200925
Upper gastrointestinal haemorrhage 151.65 12.48 851 600215 24667 34331198
Overdose 142.88 12.48 947 600119 90112 34265753
Transient ischaemic attack 136.08 12.48 877 600189 26736 34329129
Haemoglobin decreased 135.15 12.48 2868 598198 117904 34237961
Drug resistance 134.68 12.48 148 600918 25779 34330086
Coma 134.06 12.48 374 600692 45304 34310561
Milk-alkali syndrome 129.98 12.48 97 600969 508 34355357
Syncope 121.55 12.48 2229 598837 89222 34266643
Cytomegalovirus infection 121.15 12.48 163 600903 25972 34329893
Dizziness 117.74 12.48 4733 596333 213788 34142077
Atrial fibrillation 117.39 12.48 2844 598222 119549 34236316
Serotonin syndrome 114.76 12.48 104 600962 19829 34336036
Appendicolith 113.71 12.48 9 601057 8592 34347273
Vascular stent thrombosis 107.11 12.48 186 600880 2749 34353116
Multiple organ dysfunction syndrome 106.61 12.48 824 600242 75742 34280123
Labelled drug-drug interaction medication error 106.50 12.48 524 600542 14415 34341450
Gastric ulcer 105.97 12.48 541 600525 15109 34340756
Intentional self-injury 101.52 12.48 55 601011 13716 34342149
Immune reconstitution inflammatory syndrome 101.02 12.48 15 601051 8744 34347121
Somnolence 100.92 12.48 1325 599741 109791 34246074
Poisoning 100.60 12.48 42 601024 12184 34343681
Plasma cell myeloma 100.57 12.48 1136 599930 40901 34314964
Sopor 99.37 12.48 42 601024 12094 34343771
Respiratory depression 96.85 12.48 82 600984 16163 34339702
Psychotic disorder 96.56 12.48 170 600896 24282 34331583
Poisoning deliberate 96.32 12.48 11 601055 7833 34348032
Haematemesis 95.84 12.48 809 600257 26902 34328963
Hepatocellular injury 94.61 12.48 147 600919 22064 34333801
Post transplant lymphoproliferative disorder 91.70 12.48 5 601061 6523 34349342
Pathogen resistance 91.18 12.48 25 601041 9457 34346408
Myelosuppression 90.46 12.48 119 600947 19146 34336719
Treatment failure 89.61 12.48 455 600611 46242 34309623
Product use issue 89.56 12.48 677 600389 62539 34293326
Fall 88.79 12.48 4302 596764 198583 34157282
Neuroleptic malignant syndrome 88.14 12.48 107 600959 17827 34338038
Duodenal ulcer 88.14 12.48 382 600684 9950 34345915
Rheumatoid arthritis 87.28 12.48 1024 600042 37214 34318651
Venoocclusive liver disease 86.63 12.48 16 601050 7950 34347915
Suicidal ideation 85.41 12.48 380 600686 40008 34315857
Respiratory arrest 84.22 12.48 227 600839 27816 34328049
Drug interaction 84.20 12.48 3107 597959 222839 34133026
Septic shock 82.71 12.48 812 600254 71022 34284843
Drug ineffective for unapproved indication 81.44 12.48 179 600887 23536 34332329
Vascular graft 81.41 12.48 115 600951 1407 34354458
Haemorrhage intracranial 80.12 12.48 509 600557 15437 34340428
Ascites 79.89 12.48 471 600595 46100 34309765
Diverticulum 78.23 12.48 286 600780 6873 34348992
Acute graft versus host disease 77.68 12.48 10 601056 6493 34349372
Carotid artery stenosis 76.93 12.48 225 600841 4794 34351071
Hospitalisation 76.58 12.48 618 600448 56284 34299581
Fatigue 76.35 12.48 7379 593687 363274 33992591
Faeces discoloured 76.05 12.48 477 600589 14401 34341464
Neurotoxicity 75.94 12.48 120 600946 17890 34337975
Haematocrit decreased 75.42 12.48 867 600199 31349 34324516
Sepsis 75.08 12.48 2235 598831 164326 34191539
Hepatic function abnormal 73.30 12.48 454 600612 43909 34311956
Mitral valve incompetence 72.63 12.48 473 600593 14470 34341395
Lower gastrointestinal haemorrhage 72.04 12.48 338 600728 9114 34346751
Thrombosis 72.00 12.48 1244 599822 49214 34306651
Sedation 71.76 12.48 159 600907 20847 34335018
Interstitial lung disease 71.40 12.48 747 600319 64535 34291330
Coronary artery thrombosis 71.32 12.48 131 600935 2028 34353837
Arteriosclerosis 71.01 12.48 399 600667 11569 34344296
Coronary artery restenosis 70.52 12.48 88 600978 946 34354919
Mucosal inflammation 70.36 12.48 383 600683 38239 34317626
Substance abuse 70.08 12.48 22 601044 7619 34348246
Akathisia 69.78 12.48 26 601040 8083 34347782
Seizure 69.41 12.48 1327 599739 103530 34252335
Bronchopulmonary aspergillosis 69.39 12.48 90 600976 14569 34341296
Ischaemic cardiomyopathy 68.77 12.48 254 600812 6135 34349730
Aggression 68.47 12.48 391 600675 38573 34317292
Arteriosclerosis coronary artery 68.06 12.48 407 600659 12078 34343787
Vomiting 68.03 12.48 3522 597544 244099 34111766
Posterior reversible encephalopathy syndrome 67.40 12.48 44 601022 9910 34345955
Gastritis erosive 67.38 12.48 240 600826 5692 34350173
Vascular stent stenosis 67.31 12.48 92 600974 1089 34354776
Neoplasm progression 66.71 12.48 193 600873 23107 34332758
Rash maculo-papular 66.17 12.48 258 600808 28193 34327672
Haematuria 66.00 12.48 1219 599847 48847 34307018
Haemophagocytic lymphohistiocytosis 65.25 12.48 76 600990 12897 34342968
Graft versus host disease 64.68 12.48 52 601014 10517 34345348
Gastritis 64.58 12.48 617 600449 21256 34334609
Drug withdrawal syndrome 62.27 12.48 157 600909 19677 34336188
Infective pulmonary exacerbation of cystic fibrosis 61.63 12.48 20 601046 6781 34349084
Cardiac disorder 61.44 12.48 1063 600003 42063 34313802
Incorrect route of product administration 60.63 12.48 101 600965 14744 34341121
Intentional product use issue 60.41 12.48 697 600369 59119 34296746
Mucormycosis 60.35 12.48 14 601052 5928 34349937
Haematotoxicity 60.00 12.48 33 601033 8161 34347704
Acute graft versus host disease in skin 59.77 12.48 9 601057 5192 34350673
Cytokine release syndrome 59.47 12.48 198 600868 22679 34333186
Aspergillus infection 59.29 12.48 74 600992 12180 34343685
Therapy partial responder 59.23 12.48 47 601019 9569 34346296
Hyperlipidaemia 58.91 12.48 440 600626 14089 34341776
Toxic epidermal necrolysis 57.90 12.48 185 600881 21461 34334404
Suspected suicide 57.45 12.48 7 601059 4741 34351124
Gastrooesophageal reflux disease 56.28 12.48 941 600125 36983 34318882
Acute coronary syndrome 55.94 12.48 412 600654 13133 34342732
Cerebral haemorrhage 55.62 12.48 877 600189 34060 34321805
Agranulocytosis 54.77 12.48 217 600849 23604 34332261
Haematochezia 54.55 12.48 1113 599953 45421 34310444
Agitation 54.46 12.48 678 600388 56721 34299144
Cytomegalovirus viraemia 54.30 12.48 30 601036 7400 34348465
Accidental exposure to product 54.26 12.48 85 600981 12717 34343148
Adenovirus infection 54.17 12.48 12 601054 5245 34350620
Occult blood positive 54.13 12.48 173 600893 3875 34351990
Bone marrow failure 53.88 12.48 289 600777 28964 34326901
Leukopenia 52.90 12.48 761 600305 62095 34293770
Rectal haemorrhage 52.70 12.48 979 600087 39270 34316595
Wrong technique in product usage process 50.66 12.48 386 600680 35600 34320265
Multiple-drug resistance 50.02 12.48 14 601052 5225 34350640
Appendicitis 49.83 12.48 113 600953 14694 34341171
Hepatic failure 49.75 12.48 368 600698 34163 34321702
Aspirin-exacerbated respiratory disease 49.59 12.48 46 601020 341 34355524
Subdural haematoma 49.34 12.48 553 600513 19868 34335997
Stomatitis 49.15 12.48 480 600586 42034 34313831
Peripheral vascular disorder 49.09 12.48 194 600872 4842 34351023
Hepatitis B reactivation 48.94 12.48 5 601061 3886 34351979
Status epilepticus 48.63 12.48 89 600977 12525 34343340
Febrile bone marrow aplasia 47.05 12.48 43 601023 8166 34347699
BK virus infection 46.75 12.48 20 601046 5718 34350147
Miosis 46.74 12.48 57 601009 9478 34346387
Dyspnoea 46.55 12.48 7266 593800 369516 33986349
Drug use disorder 46.48 12.48 8 601058 4183 34351682
Cardio-respiratory arrest 46.23 12.48 670 600396 54603 34301262
Tumour lysis syndrome 46.18 12.48 145 600921 16914 34338951
Contusion 46.06 12.48 880 600186 35484 34320381
Thrombocytopenia 46.00 12.48 2206 598860 154041 34201824
Dystonia 45.97 12.48 72 600994 10773 34345092
Cystitis haemorrhagic 45.94 12.48 20 601046 5659 34350206
No adverse event 45.92 12.48 220 600846 22707 34333158
Graft versus host disease in gastrointestinal tract 45.64 12.48 5 601061 3678 34352187
Thrombotic microangiopathy 45.60 12.48 70 600996 10560 34345305
Systemic infection 45.45 12.48 194 600872 5018 34350847
Respiratory failure 45.42 12.48 1471 599595 107101 34248764
Chronic graft versus host disease 45.02 12.48 10 601056 4363 34351502
International normalised ratio increased 44.77 12.48 1098 599968 46229 34309636
Palmar-plantar erythrodysaesthesia syndrome 44.60 12.48 144 600922 16651 34339214
Ventricular hypertrophy 44.53 12.48 177 600889 4430 34351435
Altered state of consciousness 44.51 12.48 222 600844 22671 34333194
Hyperthermia 44.09 12.48 71 600995 10506 34345359
Tricuspid valve incompetence 43.86 12.48 303 600763 9457 34346408
Withdrawal syndrome 43.60 12.48 93 600973 12362 34343503
Cholestasis 42.85 12.48 279 600787 26669 34329196
Pain in extremity 42.61 12.48 2619 598447 123894 34231971
Chronic obstructive pulmonary disease 42.18 12.48 1121 599945 47797 34308068
Depressed level of consciousness 42.17 12.48 502 600564 42339 34313526
Condition aggravated 41.72 12.48 2795 598271 189401 34166464
Shunt stenosis 41.70 12.48 59 601007 723 34355142
Hyperbilirubinaemia 41.60 12.48 149 600917 16694 34339171
Cardiovascular disorder 41.60 12.48 306 600760 9750 34346115
Dyspnoea exertional 41.51 12.48 1006 600060 42273 34313592
Colorectal cancer 41.41 12.48 15 601051 4746 34351119
Neutrophil count decreased 41.17 12.48 624 600442 50480 34305385
Exposure to toxic agent 40.79 12.48 7 601059 3668 34352197
Progressive multifocal leukoencephalopathy 40.28 12.48 66 601000 9698 34346167
Pneumocystis jirovecii pneumonia 40.14 12.48 188 600878 19522 34336343
Pneumonia aspiration 40.10 12.48 494 600572 41409 34314456
Virologic failure 40.04 12.48 6 601060 3474 34352391
Chest discomfort 39.93 12.48 1224 599842 53306 34302559
Diastolic dysfunction 39.90 12.48 212 600854 6015 34349850
Syringe issue 39.78 12.48 24 601042 5640 34350225
Myalgia 39.35 12.48 1796 599270 82314 34273551
Asthenia 39.24 12.48 4803 596263 240448 34115417
Epstein-Barr virus infection 39.11 12.48 44 601022 7584 34348281
Haematoma 38.97 12.48 638 600428 24967 34330898
Irritability 38.56 12.48 257 600809 24433 34331432
Obsessive-compulsive disorder 38.49 12.48 24 601042 5540 34350325
Hyperammonaemia 38.12 12.48 32 601034 6335 34349530
Lymphopenia 38.07 12.48 148 600918 16187 34339678
Rhabdomyolysis 37.64 12.48 1481 599585 66682 34289183
Hiatus hernia 37.15 12.48 242 600824 7403 34348462
Therapeutic product effect incomplete 36.76 12.48 629 600437 49912 34305953
Ventricular extrasystoles 36.57 12.48 341 600725 11667 34344198
Brain oedema 36.35 12.48 119 600947 13702 34342163
Apparent death 36.20 12.48 9 601057 3635 34352230
Disinhibition 36.13 12.48 6 601060 3220 34352645
Dysmorphism 36.11 12.48 128 600938 3028 34352837
Stent placement 36.11 12.48 178 600888 4900 34350965
Multiple injuries 36.08 12.48 92 600974 1803 34354062
Abnormal behaviour 36.01 12.48 266 600800 24703 34331162
Acute myeloid leukaemia 35.61 12.48 177 600889 18093 34337772
Venoocclusive disease 35.25 12.48 4 601062 2863 34353002
Carotid artery disease 34.81 12.48 59 601007 854 34355011
Device leakage 34.73 12.48 37 601029 6538 34349327
Anaemia 34.41 12.48 4547 596519 228788 34127077
Muscle spasms 34.32 12.48 1598 599468 73403 34282462
Gastric ulcer haemorrhage 34.28 12.48 185 600881 5281 34350584
Lacunar infarction 34.23 12.48 124 600942 2966 34352899
Viral mutation identified 34.20 12.48 5 601061 2949 34352916
Cytomegalovirus infection reactivation 34.14 12.48 23 601043 5095 34350770
Vascular pseudoaneurysm 34.03 12.48 98 600968 2069 34353796
Delirium 33.79 12.48 542 600524 43449 34312416
Ventricular dysfunction 33.78 12.48 145 600921 3760 34352105
Polyomavirus-associated nephropathy 33.62 12.48 12 601054 3832 34352033
Hepatitis B 33.51 12.48 32 601034 5951 34349914
Prostate cancer stage I 33.43 12.48 3 601063 2586 34353279
Encephalopathy 33.19 12.48 418 600648 34901 34320964
Peripheral arterial occlusive disease 32.99 12.48 193 600873 5681 34350184
Hepatic encephalopathy 32.98 12.48 135 600931 14550 34341315
Respiratory distress 32.44 12.48 425 600641 35240 34320625
Arterial occlusive disease 32.31 12.48 154 600912 4180 34351685
Subarachnoid haemorrhage 32.29 12.48 346 600720 12289 34343576
Tachycardia 31.86 12.48 1164 599902 83608 34272257
Lipodystrophy acquired 31.81 12.48 9 601057 3335 34352530
Cytomegalovirus chorioretinitis 31.74 12.48 11 601055 3578 34352287
Angiopathy 31.64 12.48 149 600917 4024 34351841
Intermittent claudication 31.55 12.48 99 600967 2195 34353670
Bundle branch block left 31.37 12.48 193 600873 5786 34350079
Osteoarthritis 31.29 12.48 514 600552 20128 34335737
Hyponatraemia 30.94 12.48 1136 599930 81555 34274310
Electrocardiogram abnormal 30.93 12.48 268 600798 8979 34346886
Oedema peripheral 30.35 12.48 2423 598643 117389 34238476
Shunt occlusion 30.28 12.48 54 601012 816 34355049
Left ventricular failure 30.19 12.48 171 600895 4973 34350892
Alcohol abuse 30.07 12.48 22 601044 4668 34351197
Graft versus host disease in skin 29.93 12.48 15 601051 3910 34351955
Lymphocyte count decreased 29.82 12.48 247 600819 22375 34333490
Mydriasis 29.77 12.48 49 601017 7188 34348677
Psychiatric decompensation 29.67 12.48 7 601059 2930 34352935
Aplastic anaemia 29.66 12.48 78 600988 9638 34346227
Peptic ulcer 29.42 12.48 110 600956 2673 34353192
Non-cardiac chest pain 29.40 12.48 149 600917 4148 34351717
Cardiac murmur 29.35 12.48 233 600833 7604 34348261
Fungal infection 29.02 12.48 158 600908 15777 34340088
Helicobacter gastritis 28.92 12.48 65 601001 1171 34354694
Lactic acidosis 28.89 12.48 422 600644 34350 34321515
Full blood count decreased 28.76 12.48 454 600612 17634 34338231
Electrocardiogram QT prolonged 28.71 12.48 513 600553 40439 34315426
Post procedural complication 28.70 12.48 311 600755 11077 34344788
Ejection fraction decreased 28.68 12.48 476 600590 18678 34337187
Post procedural haemorrhage 28.65 12.48 242 600824 8047 34347818
Eye haemorrhage 28.57 12.48 148 600918 4157 34351708
Euphoric mood 28.42 12.48 33 601033 5608 34350257
Diffuse large B-cell lymphoma recurrent 28.37 12.48 10 601056 3218 34352647
Aortic stenosis 28.35 12.48 149 600917 4209 34351656
Duodenal ulcer haemorrhage 28.34 12.48 165 600901 4848 34351017
Acute graft versus host disease in intestine 28.27 12.48 6 601060 2702 34353163
Sickle cell anaemia with crisis 28.06 12.48 141 600925 3912 34351953
Hepatocellular carcinoma 28.05 12.48 54 601012 7455 34348410
Extrapyramidal disorder 27.94 12.48 120 600946 12760 34343105
Iron deficiency anaemia 27.88 12.48 286 600780 10043 34345822
Percutaneous coronary intervention 27.84 12.48 27 601039 213 34355652
Hypercholesterolaemia 27.79 12.48 251 600815 8511 34347354
Ventricular hypokinesia 27.75 12.48 177 600889 5375 34350490
Hallucination, auditory 27.75 12.48 108 600958 11809 34344056
Acute respiratory distress syndrome 27.63 12.48 299 600767 25670 34330195
Drug hypersensitivity 27.56 12.48 1118 599948 79411 34276454
Aplasia 27.54 12.48 23 601043 4565 34351300
Wrong patient received product 27.46 12.48 6 601060 2648 34353217
Ventricular tachycardia 27.37 12.48 624 600442 25955 34329910
Nausea 27.34 12.48 5291 595775 334617 34021248
Injection site pain 27.22 12.48 489 600577 38516 34317349
Retroperitoneal haemorrhage 27.15 12.48 110 600956 2778 34353087
Pseudomonas infection 27.08 12.48 115 600951 12267 34343598
Drug level increased 27.02 12.48 246 600820 21850 34334015
Hyperthermia malignant 26.86 12.48 3 601063 2174 34353691
Sinus node dysfunction 26.77 12.48 144 600922 4105 34351760
Prostate cancer stage IV 26.74 12.48 5 601061 2463 34353402
Unintentional medical device removal 26.71 12.48 7 601059 2729 34353136
Duodenitis 26.70 12.48 158 600908 4670 34351195
Transaminases increased 26.51 12.48 314 600752 26509 34329356
Prescription drug used without a prescription 26.50 12.48 3 601063 2151 34353714
Acute hepatic failure 26.49 12.48 138 600928 13936 34341929
Paranoia 26.45 12.48 112 600954 11956 34343909
Gastrointestinal arteriovenous malformation 26.33 12.48 32 601034 334 34355531
Transplant rejection 26.28 12.48 90 600976 10221 34345644
Aortic aneurysm 26.19 12.48 203 600863 6576 34349289
Cardiomegaly 25.89 12.48 391 600675 15047 34340818
Ecchymosis 25.89 12.48 203 600863 6600 34349265
Speech disorder developmental 25.84 12.48 90 600976 2110 34353755
Adrenal insufficiency 25.74 12.48 139 600927 13908 34341957
Hypokalaemia 25.71 12.48 783 600283 57431 34298434
Blood urea increased 25.65 12.48 694 600372 29670 34326195
Accidental overdose 25.60 12.48 222 600844 19918 34335947
Back disorder 25.60 12.48 199 600867 6452 34349413
Arterial restenosis 25.39 12.48 16 601050 60 34355805
Toxic skin eruption 25.36 12.48 105 600961 11280 34344585
Device use error 25.34 12.48 5 601061 2370 34353495
Retroperitoneal haematoma 25.17 12.48 102 600964 2576 34353289
Nephropathy toxic 25.09 12.48 121 600945 12467 34343398
Haemorrhagic stroke 24.81 12.48 195 600871 6344 34349521
Nocardiosis 24.73 12.48 19 601047 3932 34351933
Benign prostatic hyperplasia 24.65 12.48 368 600698 14127 34341738
Aortic valve incompetence 24.61 12.48 180 600886 5724 34350141
Small intestinal haemorrhage 24.60 12.48 86 600980 2020 34353845
Disseminated intravascular coagulation 24.51 12.48 248 600818 21568 34334297
Mitochondrial toxicity 24.35 12.48 8 601058 2691 34353174
Arthralgia 24.33 12.48 3308 597758 166733 34189132
Tooth disorder 24.19 12.48 290 600776 10592 34345273
Electrocardiogram Q wave abnormal 24.13 12.48 34 601032 415 34355450
Skin toxicity 24.09 12.48 28 601038 4756 34351109
Blood glucose increased 23.91 12.48 1389 599677 65329 34290536
Intraventricular haemorrhage 23.86 12.48 122 600944 3409 34352456
Psychomotor hyperactivity 23.84 12.48 85 600981 9537 34346328
Osteonecrosis of jaw 23.73 12.48 195 600871 17694 34338171
Dilatation atrial 23.68 12.48 83 600983 1952 34353913
Arterial haemorrhage 23.63 12.48 49 601017 833 34355032
Second primary malignancy 23.55 12.48 64 601002 7822 34348043
Acute generalised exanthematous pustulosis 23.38 12.48 51 601015 6725 34349140
Cytopenia 23.26 12.48 126 600940 12597 34343268
Large intestine polyp 23.23 12.48 223 600843 7691 34348174
Carotid bruit 23.13 12.48 22 601044 169 34355696
Arthropathy 23.02 12.48 616 600450 26291 34329574
Oesophageal ulcer 22.97 12.48 117 600949 3264 34352601
Localised infection 22.74 12.48 427 600639 17160 34338705
Cerebrovascular disorder 22.68 12.48 76 600990 1746 34354119
Myoclonus 22.63 12.48 154 600912 14571 34341294
Hepatotoxicity 22.60 12.48 248 600818 21237 34334628
Stenosis 22.54 12.48 66 601000 1407 34354458
Sleep terror 22.50 12.48 6 601060 2312 34353553
Paradoxical drug reaction 22.43 12.48 15 601051 3336 34352529
Sudden cardiac death 22.36 12.48 124 600942 3577 34352288
Aortic valve stenosis 22.34 12.48 99 600967 2604 34353261
Hepatitis C 22.31 12.48 90 600976 9740 34346125
Epilepsy 22.26 12.48 249 600817 21246 34334619
Candida infection 22.20 12.48 196 600870 17519 34338346
Acute kidney injury 22.11 12.48 4772 596294 300216 34055649
Blood phosphorus increased 22.07 12.48 64 601002 7657 34348208
Vitreous haemorrhage 22.00 12.48 90 600976 2283 34353582
Muscular weakness 21.96 12.48 1495 599571 71402 34284463
Gingival bleeding 21.93 12.48 200 600866 6800 34349065
Occult blood 21.84 12.48 47 601019 821 34355044
Page kidney 21.80 12.48 13 601053 43 34355822
Generalised tonic-clonic seizure 21.65 12.48 246 600820 20928 34334937
Mania 21.63 12.48 87 600979 9424 34346441
Myocarditis 21.57 12.48 142 600924 13540 34342325
Spinal epidural haematoma 21.52 12.48 27 601039 292 34355573
Product monitoring error 21.49 12.48 139 600927 4242 34351623
Body height decreased 21.41 12.48 126 600940 3717 34352148
Blood loss anaemia 21.22 12.48 225 600841 7969 34347896
Basal ganglia infarction 21.19 12.48 22 601044 190 34355675
Lymphoma 21.17 12.48 127 600939 12380 34343485
Epistaxis 21.12 12.48 1214 599852 57037 34298828
Drug screen positive 21.04 12.48 22 601044 3921 34351944
Bacteraemia 20.98 12.48 227 600839 19490 34336375
Alcohol interaction 20.94 12.48 12 601054 2901 34352964
Accidental death 20.92 12.48 8 601058 2448 34353417
Stevens-Johnson syndrome 20.89 12.48 212 600854 18427 34337438
Electrocardiogram ST segment depression 20.86 12.48 91 600975 2377 34353488
Gout 20.77 12.48 455 600611 18798 34337067
Chromaturia 20.70 12.48 358 600708 14162 34341703
Catatonia 20.69 12.48 34 601032 4991 34350874
Heart rate irregular 20.52 12.48 384 600682 15423 34340442
Enterocolitis 20.49 12.48 70 600996 7956 34347909
Thrombotic thrombocytopenic purpura 20.42 12.48 113 600953 3257 34352608
Electrocardiogram ST segment elevation 20.32 12.48 157 600909 5081 34350784
Spinal disorder 20.30 12.48 134 600932 4118 34351747
Nocturia 20.10 12.48 266 600800 9944 34345921
Psychotic symptom 20.07 12.48 3 601063 1740 34354125
Nasopharyngitis 20.04 12.48 1429 599637 68539 34287326
Platelet function test abnormal 19.96 12.48 17 601049 111 34355754
Bradypnoea 19.85 12.48 12 601054 2817 34353048
Infusion related reaction 19.81 12.48 729 600337 52328 34303537
Device related infection 19.75 12.48 195 600871 17042 34338823
Wound 19.61 12.48 362 600704 14502 34341363
Blood pressure systolic increased 19.50 12.48 525 600541 22427 34333438
Spinal osteoarthritis 19.45 12.48 210 600856 7473 34348392
Increased tendency to bruise 19.40 12.48 128 600938 3933 34351932
Hand deformity 19.39 12.48 120 600946 3605 34352260
Traumatic intracranial haemorrhage 19.37 12.48 40 601026 678 34355187
Blood creatinine increased 19.28 12.48 1890 599176 93086 34262779
Haemorrhoids 19.24 12.48 355 600711 14220 34341645
Puncture site haemorrhage 19.16 12.48 25 601041 282 34355583
Hungry bone syndrome 19.10 12.48 14 601052 71 34355794
Human herpesvirus 6 infection 19.07 12.48 6 601060 2075 34353790
Antipsychotic drug level below therapeutic 19.03 12.48 10 601056 2537 34353328
Coagulation time abnormal 18.95 12.48 18 601048 138 34355727
Pancytopenia 18.93 12.48 1394 599672 93763 34262102
Extraocular muscle disorder 18.82 12.48 20 601046 178 34355687
Musculoskeletal discomfort 18.82 12.48 217 600849 7851 34348014
Enterococcal infection 18.81 12.48 89 600977 9217 34346648
Peripheral artery aneurysm 18.81 12.48 31 601035 438 34355427
Viral load increased 18.76 12.48 10 601056 2517 34353348
Back pain 18.75 12.48 2380 598686 119409 34236456
Bacterial infection 18.74 12.48 195 600871 16868 34338997
Cardiac aneurysm 18.69 12.48 47 601019 913 34354952
Metabolic acidosis 18.68 12.48 590 600476 43090 34312775
Blood creatine phosphokinase MB increased 18.66 12.48 73 600993 1813 34354052
Heparin-induced thrombocytopenia 18.63 12.48 162 600904 5433 34350432
Acute lymphocytic leukaemia recurrent 18.60 12.48 15 601051 3029 34352836
Systemic candida 18.55 12.48 22 601044 3704 34352161
Coronary angioplasty 18.54 12.48 29 601037 391 34355474
Coronary ostial stenosis 18.52 12.48 14 601052 75 34355790
Hypercalcaemia 18.46 12.48 371 600695 15097 34340768
Cataract 18.42 12.48 585 600481 25601 34330264
Post procedural haematoma 18.42 12.48 63 601003 1463 34354402
Hypoalbuminaemia 18.37 12.48 128 600938 12046 34343819
Hepatic cytolysis 18.33 12.48 160 600906 14336 34341529
Cholelithiasis 18.33 12.48 485 600581 20663 34335202
Product dose omission issue 18.23 12.48 1791 599275 117920 34237945
Hypogammaglobulinaemia 18.11 12.48 70 600996 7670 34348195
Plantar fasciitis 17.87 12.48 78 600988 2038 34353827
Low density lipoprotein increased 17.79 12.48 134 600932 4302 34351563
Atrial flutter 17.75 12.48 371 600695 15203 34340662
Swollen tongue 17.66 12.48 351 600715 14254 34341611
Hallucination 17.60 12.48 715 600351 50783 34305082
Vascular graft occlusion 17.59 12.48 34 601032 548 34355317
Gastrointestinal ulcer 17.56 12.48 67 600999 1644 34354221
Hypertriglyceridaemia 17.54 12.48 80 600986 8368 34347497
Coronary artery insufficiency 17.45 12.48 14 601052 83 34355782
Psoriatic arthropathy 17.44 12.48 455 600611 19343 34336522
Haemorrhage urinary tract 17.32 12.48 71 600995 1803 34354062
Blindness transient 17.26 12.48 80 600986 2146 34353719
Palmoplantar keratoderma 17.25 12.48 6 601060 1947 34353918
Diabetic foot 17.24 12.48 94 600972 2694 34353171
International normalised ratio decreased 17.22 12.48 136 600930 4431 34351434
Helicobacter test positive 17.20 12.48 43 601023 832 34355033
Dermatitis acneiform 17.18 12.48 52 601014 6137 34349728
Ulcer haemorrhage 17.17 12.48 91 600975 2579 34353286
Diffuse large B-cell lymphoma 17.03 12.48 67 600999 7303 34348562
Hypoxia 16.95 12.48 774 600292 54321 34301544
Prostate cancer stage III 16.74 12.48 5 601061 1788 34354077
High density lipoprotein decreased 16.72 12.48 107 600959 3253 34352612
Myocardial rupture 16.70 12.48 18 601048 163 34355702
Eosinophilia 16.67 12.48 334 600732 25888 34329977
Pneumatosis intestinalis 16.67 12.48 26 601040 3897 34351968
Depression 16.60 12.48 1440 599626 95658 34260207
Mallory-Weiss syndrome 16.59 12.48 57 601009 1327 34354538
Nasal polyps 16.57 12.48 86 600980 2417 34353448
Ischaemia 16.52 12.48 135 600931 4445 34351420
Sedation complication 16.51 12.48 5 601061 1772 34354093
Vascular graft complication 16.50 12.48 15 601051 108 34355757
Complications of transplanted kidney 16.48 12.48 34 601032 4575 34351290
Prosthesis implantation 16.45 12.48 8 601058 15 34355850
Therapy non-responder 16.44 12.48 530 600536 38616 34317249
Klebsiella infection 16.43 12.48 83 600983 8448 34347417
Immune effector cell-associated neurotoxicity syndrome 16.36 12.48 24 601042 3689 34352176
Drug-induced liver injury 16.36 12.48 374 600692 28458 34327407
Micturition urgency 16.35 12.48 178 600888 6347 34349518
Renal cyst 16.31 12.48 233 600833 8860 34347005
Blood pressure diastolic decreased 16.30 12.48 233 600833 8861 34347004
Stenotrophomonas infection 16.19 12.48 8 601058 2102 34353763
Cough 16.15 12.48 2875 598191 147265 34208600
Inappropriate schedule of product administration 16.10 12.48 891 600175 61405 34294460
Oesophageal carcinoma 16.00 12.48 94 600972 9210 34346655
Anaphylactic shock 15.99 12.48 186 600880 15755 34340110
Vertebral artery stenosis 15.96 12.48 16 601050 132 34355733
Agonal rhythm 15.92 12.48 12 601054 64 34355801
Asphyxia 15.88 12.48 62 601004 6773 34349092
Fat embolism 15.75 12.48 18 601048 175 34355690
Depression suicidal 15.74 12.48 12 601054 2493 34353372
Erosive duodenitis 15.68 12.48 65 601001 1659 34354206
Encephalitis 15.66 12.48 68 600998 7209 34348656
Hepatitis 15.64 12.48 303 600763 23601 34332264
Hypoaesthesia 15.60 12.48 1243 599823 60201 34295664
Metastases to lung 15.58 12.48 95 600971 9225 34346640
Prostate cancer stage II 15.56 12.48 10 601056 2271 34353594
Retinal artery occlusion 15.55 12.48 69 600997 1816 34354049
Injection site reaction 15.55 12.48 146 600920 12887 34342978
Restlessness 15.48 12.48 327 600739 25155 34330710
Lung disorder 15.48 12.48 466 600600 34230 34321635
Anaemia macrocytic 15.45 12.48 97 600969 2929 34352936
Aortic arteriosclerosis 15.32 12.48 134 600932 4502 34351363
Infection 15.29 12.48 1350 599716 89565 34266300
Granulomatous pneumonitis 15.26 12.48 9 601057 29 34355836
Blood bilirubin increased 15.25 12.48 522 600544 37774 34318091
Foetal anticonvulsant syndrome 15.21 12.48 50 601016 1137 34354728
Silent myocardial infarction 15.17 12.48 26 601040 380 34355485
Chronic kidney disease 15.15 12.48 860 600206 40350 34315515
Reye's syndrome 15.14 12.48 7 601059 11 34355854
Red blood cell count decreased 15.11 12.48 628 600438 28462 34327403
Coronary artery embolism 15.09 12.48 16 601050 142 34355723
Dyspepsia 14.99 12.48 774 600292 35958 34319907
Methaemoglobinaemia 14.96 12.48 24 601042 3557 34352308
Subdural haemorrhage 14.89 12.48 100 600966 3091 34352774
Polyneuropathy 14.86 12.48 174 600892 14722 34341143
Graft thrombosis 14.85 12.48 22 601044 282 34355583
Gallbladder disorder 14.83 12.48 175 600891 6367 34349498
Product substitution issue 14.82 12.48 107 600959 9988 34345877
Ischaemic stroke 14.81 12.48 415 600651 17835 34338030
Pericardial haemorrhage 14.76 12.48 99 600967 3059 34352806
Spinal stenosis 14.75 12.48 147 600919 5122 34350743
Intervertebral disc degeneration 14.70 12.48 172 600894 6245 34349620
JC virus infection 14.63 12.48 10 601056 2198 34353667
Strongyloidiasis 14.61 12.48 15 601051 2696 34353169
Vascular calcification 14.60 12.48 39 601027 787 34355078
Cardiotoxicity 14.60 12.48 49 601017 5599 34350266
Blood prolactin increased 14.55 12.48 6 601060 1754 34354111
Atrioventricular septal defect 14.52 12.48 19 601047 215 34355650
Salivary hypersecretion 14.51 12.48 88 600978 8556 34347309
Hepatojugular reflux 14.50 12.48 32 601034 569 34355296
Pericardial disease 14.48 12.48 27 601039 423 34355442
Osteonecrosis 14.45 12.48 175 600891 14715 34341150
Ulnar nerve injury 14.44 12.48 7 601059 13 34355852
Catheterisation cardiac 14.42 12.48 87 600979 2590 34353275
Hyperpyrexia 14.38 12.48 16 601050 2772 34353093
Leukoencephalopathy 14.32 12.48 32 601034 4183 34351682
Basal cell carcinoma 14.31 12.48 441 600625 19217 34336648
Pneumonia fungal 14.29 12.48 68 600998 7032 34348833
Hypertension 14.27 12.48 2609 598457 133834 34222031
Mitral valve calcification 14.24 12.48 31 601035 546 34355319
Colonic haematoma 14.23 12.48 9 601057 34 34355831
Persecutory delusion 14.22 12.48 14 601052 2566 34353299
Troponin increased 14.21 12.48 275 600791 11114 34344751
Blood homocysteine increased 14.20 12.48 20 601046 244 34355621
Pneumonia cytomegaloviral 14.20 12.48 19 601047 3035 34352830
Arteriovenous malformation 14.19 12.48 38 601028 768 34355097
Stress 14.19 12.48 405 600661 29942 34325923
Foetal exposure during pregnancy 14.18 12.48 796 600270 37305 34318560
Angioedema 14.14 12.48 782 600284 36592 34319273
Vitamin B12 deficiency 14.10 12.48 118 600948 3913 34351952
Terminal state 14.08 12.48 29 601037 3905 34351960
Fungaemia 14.08 12.48 14 601052 2554 34353311
Congenital hiatus hernia 14.07 12.48 39 601027 805 34355060
Multiple sclerosis relapse 14.05 12.48 151 600915 12982 34342883
Intracardiac thrombus 14.01 12.48 82 600984 2414 34353451
Accidental exposure to product by child 13.99 12.48 4 601062 1472 34354393
Clonus 13.95 12.48 16 601050 2734 34353131
Lactose intolerance 13.92 12.48 52 601014 1263 34354602
Dementia 13.92 12.48 322 600744 13426 34342439
Therapeutic product effect variable 13.91 12.48 13 601053 2443 34353422
Inappropriate antidiuretic hormone secretion 13.90 12.48 146 600920 12607 34343258
Middle ear effusion 13.84 12.48 33 601033 619 34355246
Epigastric discomfort 13.83 12.48 75 600991 2145 34353720
Skin flap necrosis 13.81 12.48 7 601059 15 34355850
Product administered to patient of inappropriate age 13.80 12.48 22 601044 3269 34352596
Alopecia 13.80 12.48 316 600750 24039 34331826
Colitis 13.80 12.48 520 600546 37230 34318635
Oculogyric crisis 13.79 12.48 5 601061 1581 34354284
Congenital central nervous system anomaly 13.77 12.48 32 601034 590 34355275
Nasal turbinate hypertrophy 13.75 12.48 13 601053 99 34355766
Mediastinal haematoma 13.75 12.48 13 601053 99 34355766
Platelet aggregation increased 13.74 12.48 8 601058 25 34355840
Liver abscess 13.70 12.48 29 601037 3866 34351999
Gastric ulcer perforation 13.70 12.48 45 601021 1023 34354842
Diverticulum intestinal 13.69 12.48 117 600949 3904 34351961
Left ventricular hypertrophy 13.67 12.48 206 600860 7924 34347941
Pleuritic pain 13.66 12.48 106 600960 3435 34352430
Rotator cuff syndrome 13.65 12.48 153 600913 5496 34350369
Blood urine present 13.65 12.48 262 600804 10572 34345293
Rhinitis perennial 13.64 12.48 22 601044 305 34355560
Muscle haemorrhage 13.63 12.48 110 600956 3608 34352257
Systemic mycosis 13.61 12.48 5 601061 1568 34354297
Cerebral artery occlusion 13.55 12.48 36 601030 724 34355141
Small intestine polyp 13.51 12.48 7 601059 16 34355849
Disturbance in attention 13.50 12.48 341 600725 25604 34330261
Anaemia of malignant disease 13.49 12.48 27 601039 447 34355418
Shunt thrombosis 13.49 12.48 11 601055 67 34355798
Thrombotic stroke 13.46 12.48 20 601046 257 34355608
Haemorrhagic cholecystitis 13.46 12.48 12 601054 84 34355781
Cardiac tamponade 13.36 12.48 144 600922 5122 34350743
Angioplasty 13.35 12.48 43 601023 967 34354898
Fractional exhaled nitric oxide increased 13.35 12.48 45 601021 1037 34354828
Urticaria 13.34 12.48 908 600158 61469 34294396
Venous pressure jugular increased 13.34 12.48 37 601029 764 34355101
Chronic coronary syndrome 13.31 12.48 16 601050 165 34355700
Renal haemorrhage 13.30 12.48 55 601011 1402 34354463
Retinal artery embolism 13.30 12.48 8 601058 27 34355838
Erythema 13.26 12.48 1330 599736 87450 34268415
Bacterial sepsis 13.26 12.48 46 601020 5204 34350661
Neutrophil count increased 13.24 12.48 211 600855 16935 34338930
Arterial stent insertion 13.24 12.48 12 601054 86 34355779
Steroid diabetes 13.18 12.48 11 601055 2184 34353681
Low birth weight baby 13.17 12.48 200 600866 7705 34348160
Skin discolouration 13.17 12.48 401 600665 17444 34338421
Incision site haemorrhage 13.13 12.48 29 601037 516 34355349
Subcapsular renal haematoma 13.10 12.48 25 601041 399 34355466
Angiogram abnormal 13.09 12.48 8 601058 28 34355837
Arterial stenosis 13.09 12.48 47 601019 1119 34354746
Depressive symptom 13.08 12.48 18 601048 2841 34353024
Joint injury 13.02 12.48 226 600840 8947 34346918
Vascular procedure complication 12.96 12.48 7 601059 18 34355847
Hypertransaminasaemia 12.93 12.48 51 601015 5555 34350310
Renal tubular disorder 12.90 12.48 39 601027 4604 34351261
Gangrene 12.86 12.48 128 600938 4458 34351407
Limb discomfort 12.86 12.48 264 600802 10783 34345082
Bundle branch block right 12.85 12.48 191 600875 7325 34348540
Diabetes insipidus 12.83 12.48 19 601047 2909 34352956
Diffuse large B-cell lymphoma refractory 12.82 12.48 3 601063 1263 34354602
Implantable defibrillator insertion 12.81 12.48 36 601030 749 34355116
Blood cholesterol increased 12.69 12.48 452 600614 20091 34335774
Clostridium difficile colitis 12.68 12.48 192 600874 15538 34340327
Gastritis haemorrhagic 12.65 12.48 54 601012 1397 34354468
Physical examination abnormal 12.63 12.48 21 601045 299 34355566
Intervertebral disc protrusion 12.62 12.48 241 600825 9715 34346150
Vascular stent occlusion 12.62 12.48 16 601050 175 34355690
Malignant melanoma in situ 12.59 12.48 61 601005 1667 34354198
Barrett's oesophagus 12.58 12.48 26 601040 441 34355424
Erosive oesophagitis 12.56 12.48 55 601011 1439 34354426
Migraine 12.55 12.48 218 600848 17260 34338605
Drug dose omission by device 12.51 12.48 12 601054 2227 34353638
Neonatal respiratory distress syndrome 12.51 12.48 115 600951 3919 34351946

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2238.60 11.34 7050 1213862 177079 78346397
Completed suicide 1813.34 11.34 746 1220166 245021 78278455
Coronary artery disease 1609.17 11.34 3277 1217635 62197 78461279
Drug abuse 1590.00 11.34 285 1220627 162406 78361070
Toxicity to various agents 1350.77 11.34 2765 1218147 418775 78104701
Acute myocardial infarction 1113.68 11.34 3138 1217774 73898 78449578
Cardiac failure congestive 1093.07 11.34 4700 1216212 137702 78385774
Cerebrovascular accident 915.11 11.34 4747 1216165 150545 78372931
Off label use 729.79 11.34 9658 1211254 897557 77625919
Gastrointestinal haemorrhage 653.69 11.34 4185 1216727 143534 78379942
Febrile neutropenia 629.39 11.34 1651 1219261 229348 78294128
Drug ineffective 498.02 11.34 12682 1208230 1068231 77455245
Angina unstable 496.46 11.34 901 1220011 15626 78507850
Coronary arterial stent insertion 447.97 11.34 507 1220405 5537 78517939
Product use in unapproved indication 411.04 11.34 2203 1218709 248156 78275320
Coronary artery bypass 408.21 11.34 484 1220428 5578 78517898
Intentional overdose 362.83 11.34 667 1220245 105293 78418183
Angina pectoris 355.52 11.34 1653 1219259 50079 78473397
Death 333.57 11.34 6389 1214523 560125 77963351
Gastric haemorrhage 325.17 11.34 715 1220197 14335 78509141
Milk-alkali syndrome 320.23 11.34 224 1220688 1196 78522280
Suicide attempt 319.17 11.34 484 1220428 82448 78441028
Transient ischaemic attack 299.84 11.34 1596 1219316 51099 78472377
Malignant neoplasm progression 290.28 11.34 1085 1219827 134905 78388571
Coronary artery occlusion 280.71 11.34 682 1220230 14633 78508843
Drug reaction with eosinophilia and systemic symptoms 264.95 11.34 357 1220555 63887 78459589
Disease progression 253.13 11.34 1716 1219196 182646 78340830
Thrombosis in device 251.65 11.34 361 1220551 5081 78518395
Device expulsion 250.97 11.34 46 1220866 25815 78497661
Haemoglobin decreased 246.49 11.34 4773 1216139 217346 78306130
Overdose 238.97 11.34 1743 1219169 182463 78341013
Intentional product misuse 233.26 11.34 715 1220197 94450 78429026
Drug dependence 233.16 11.34 170 1220742 40599 78482877
Myocardial ischaemia 231.87 11.34 888 1220024 24631 78498845
Chest pain 231.81 11.34 5810 1215102 276494 78246982
Coronary artery stenosis 224.62 11.34 552 1220360 11932 78511544
Upper gastrointestinal haemorrhage 221.05 11.34 1232 1219680 40148 78483328
Neutropenia 220.78 11.34 3088 1217824 284622 78238854
Melaena 214.31 11.34 1632 1219280 59258 78464218
Sopor 211.48 11.34 121 1220791 32889 78490587
Intentional self-injury 206.03 11.34 120 1220792 32299 78491177
Labelled drug-drug interaction medication error 203.00 11.34 901 1220011 26749 78496727
Cytomegalovirus infection 200.27 11.34 214 1220698 42430 78481046
Poisoning deliberate 192.69 11.34 29 1220883 18799 78504677
Drug resistance 192.55 11.34 217 1220695 41996 78481480
Pyrexia 189.17 11.34 8480 1212432 670229 77853247
Respiratory arrest 188.44 11.34 372 1220540 57178 78466298
Coma 174.94 11.34 868 1220044 99781 78423695
Poisoning 173.14 11.34 85 1220827 25187 78498289
Respiratory depression 171.75 11.34 105 1220807 27525 78495951
Atrial fibrillation 166.89 11.34 4088 1216824 193798 78329678
Serotonin syndrome 158.98 11.34 278 1220634 44749 78478727
Fall 157.58 11.34 9046 1211866 478583 78044893
Vascular stent thrombosis 156.94 11.34 236 1220676 3474 78520002
Gastric ulcer 156.88 11.34 972 1219940 32933 78490543
Duodenal ulcer 154.83 11.34 577 1220335 15792 78507684
Somnolence 153.45 11.34 2653 1218259 236328 78287148
Myelosuppression 152.31 11.34 238 1220674 40058 78483418
Aspirin-exacerbated respiratory disease 149.96 11.34 134 1220778 1073 78522403
Drug ineffective for unapproved indication 143.36 11.34 361 1220551 50877 78472599
Haemorrhage 141.70 11.34 2069 1218843 89049 78434427
Neoplasm progression 137.82 11.34 373 1220539 51309 78472167
Rheumatoid arthritis 137.79 11.34 4173 1216739 204297 78319179
Suspected suicide 136.16 11.34 6 1220906 10570 78512906
Carotid artery stenosis 134.62 11.34 365 1220547 8393 78515083
Post transplant lymphoproliferative disorder 134.06 11.34 11 1220901 11453 78512023
Neuroleptic malignant syndrome 129.74 11.34 138 1220774 27421 78496055
Arteriosclerosis coronary artery 129.61 11.34 579 1220333 17237 78506239
Hepatocellular injury 129.56 11.34 340 1220572 47253 78476223
Plasma cell myeloma 128.95 11.34 1315 1219597 51944 78471532
Cardio-respiratory arrest 128.79 11.34 1052 1219860 107458 78416018
Venoocclusive liver disease 125.48 11.34 16 1220896 11755 78511721
Arthropathy 124.57 11.34 3573 1217339 173538 78349938
Haematotoxicity 116.09 11.34 46 1220866 15473 78508003
Multiple organ dysfunction syndrome 113.89 11.34 1233 1219679 119013 78404463
Gastritis erosive 113.35 11.34 395 1220517 10452 78513024
Suicidal ideation 111.06 11.34 698 1220214 75642 78447834
Mitral valve incompetence 111.01 11.34 784 1220128 27781 78495695
Arteriosclerosis 109.14 11.34 560 1220352 17667 78505809
Haemorrhage intracranial 108.96 11.34 731 1220181 25462 78498014
Ascites 108.33 11.34 694 1220218 74868 78448608
Haematemesis 108.29 11.34 1251 1219661 51013 78472463
Sedation 108.12 11.34 418 1220494 51477 78471999
Vascular graft 107.82 11.34 144 1220768 1887 78521589
Coronary artery thrombosis 107.16 11.34 180 1220732 2926 78520550
Acute graft versus host disease 105.57 11.34 15 1220897 10152 78513324
Faeces discoloured 105.47 11.34 786 1220126 28341 78495135
Haemophagocytic lymphohistiocytosis 105.45 11.34 107 1220805 21730 78501746
Immune reconstitution inflammatory syndrome 105.23 11.34 40 1220872 13801 78509675
Pathogen resistance 104.86 11.34 44 1220868 14298 78509178
Pemphigus 104.32 11.34 2122 1218790 97460 78426016
Hepatic function abnormal 102.49 11.34 676 1220236 72431 78451045
Haematocrit decreased 102.45 11.34 1410 1219502 59902 78463574
Posterior reversible encephalopathy syndrome 102.43 11.34 152 1220760 26129 78497347
Drug hypersensitivity 102.33 11.34 3645 1217267 295271 78228205
Bronchopulmonary aspergillosis 102.33 11.34 114 1220798 22180 78501296
Exposure to toxic agent 101.22 11.34 11 1220901 9147 78514329
Appendicolith 97.83 11.34 9 1220903 8542 78514934
Wrong technique in product usage process 97.18 11.34 696 1220216 73179 78450297
Interstitial lung disease 96.73 11.34 1180 1219732 111420 78412056
Maternal exposure during pregnancy 96.67 11.34 2757 1218155 133781 78389695
Drug use disorder 96.62 11.34 10 1220902 8641 78514835
Systemic lupus erythematosus 96.22 11.34 2483 1218429 118666 78404810
Ischaemic cardiomyopathy 95.44 11.34 297 1220615 7398 78516078
Hand deformity 94.00 11.34 2168 1218744 101751 78421725
Thrombosis 93.76 11.34 1809 1219103 82291 78441185
Cholestasis 93.66 11.34 444 1220468 51665 78471811
Vascular stent stenosis 93.19 11.34 116 1220796 1411 78522065
Rhabdomyolysis 93.11 11.34 2151 1218761 100980 78422496
Syncope 92.11 11.34 3488 1217424 175961 78347515
Accidental exposure to product 91.30 11.34 216 1220696 31106 78492370
Coronary artery restenosis 90.96 11.34 107 1220805 1222 78522254
Neurotoxicity 90.28 11.34 230 1220682 32288 78491188
Lower gastrointestinal haemorrhage 90.08 11.34 486 1220426 15639 78507837
Hepatic failure 87.33 11.34 563 1220349 60649 78462827
Graft versus host disease 86.77 11.34 62 1220850 14964 78508512
Agranulocytosis 86.73 11.34 374 1220538 44656 78478820
Mucosal inflammation 85.95 11.34 741 1220171 74839 78448637
Glossodynia 85.91 11.34 2131 1218781 101206 78422270
Wound 85.34 11.34 2357 1218555 113822 78409654
Diverticulum 85.28 11.34 452 1220460 14444 78509032
Acute graft versus host disease in skin 85.15 11.34 9 1220903 7649 78515827
Systemic infection 85.04 11.34 335 1220577 9417 78514059
Haematochezia 84.45 11.34 1845 1219067 85800 78437676
Electrocardiogram QT prolonged 83.91 11.34 931 1219981 89455 78434021
Aspergillus infection 83.62 11.34 102 1220810 19059 78504417
Bone marrow failure 83.02 11.34 451 1220461 50656 78472820
Febrile bone marrow aplasia 83.01 11.34 48 1220864 12972 78510504
Leukopenia 82.47 11.34 1270 1219642 115243 78408233
Infective pulmonary exacerbation of cystic fibrosis 82.47 11.34 47 1220865 12804 78510672
Incorrect route of product administration 82.35 11.34 267 1220645 34662 78488814
Acute myeloid leukaemia 82.27 11.34 223 1220689 30662 78492814
Adenovirus infection 82.02 11.34 15 1220897 8432 78515044
Abdominal discomfort 81.49 11.34 4655 1216257 246072 78277404
Drug withdrawal syndrome 81.42 11.34 266 1220646 34452 78489024
Neutrophil count decreased 80.94 11.34 984 1219928 92975 78430501
Cerebral haemorrhage 80.19 11.34 1285 1219627 56388 78467088
Palmar-plantar erythrodysaesthesia syndrome 79.71 11.34 251 1220661 32883 78490593
Cytomegalovirus viraemia 79.30 11.34 49 1220863 12772 78510704
Acute coronary syndrome 79.21 11.34 575 1220337 20558 78502918
Unintentional medical device removal 78.64 11.34 12 1220900 7700 78515776
Lacunar infarction 78.64 11.34 235 1220677 5722 78517754
Therapy partial responder 77.64 11.34 91 1220821 17306 78506170
Shunt stenosis 77.51 11.34 101 1220811 1290 78522186
Graft versus host disease in gastrointestinal tract 77.47 11.34 5 1220907 6351 78517125
Gastritis 77.07 11.34 1096 1219816 46897 78476579
Cytokine release syndrome 76.90 11.34 287 1220625 35711 78487765
Ventricular hypertrophy 76.30 11.34 257 1220655 6681 78516795
Withdrawal syndrome 76.05 11.34 188 1220724 26666 78496810
Dystonia 75.64 11.34 132 1220780 21267 78502209
Akathisia 74.89 11.34 56 1220856 13203 78510273
Haematuria 74.81 11.34 1475 1219437 67361 78456115
Thrombotic microangiopathy 74.45 11.34 121 1220791 20048 78503428
Substance abuse 74.26 11.34 34 1220878 10492 78512984
Mucormycosis 74.18 11.34 19 1220893 8450 78515026
Hyperlipidaemia 73.91 11.34 666 1220246 25427 78498049
Epstein-Barr virus infection 72.66 11.34 68 1220844 14348 78509128
Lymphocyte count decreased 72.64 11.34 425 1220487 46864 78476612
Gastric ulcer haemorrhage 72.29 11.34 302 1220610 8725 78514751
Status epilepticus 71.95 11.34 174 1220738 24867 78498609
Rectal haemorrhage 71.86 11.34 1601 1219311 74699 78448777
Mydriasis 71.76 11.34 99 1220813 17544 78505932
Depressed level of consciousness 71.67 11.34 1044 1219868 95608 78427868
Exposure during pregnancy 71.27 11.34 2041 1218871 99091 78424385
Seizure 71.04 11.34 2275 1218637 186559 78336917
Sepsis 70.98 11.34 3385 1217527 266043 78257433
Subdural haematoma 70.84 11.34 765 1220147 30669 78492807
Sickle cell anaemia with crisis 70.60 11.34 274 1220638 7648 78515828
Altered state of consciousness 70.47 11.34 388 1220524 43434 78480042
Rash maculo-papular 68.68 11.34 539 1220373 55539 78467937
Contusion 68.00 11.34 2856 1218056 145920 78377556
Tachycardia 68.00 11.34 2137 1218775 175631 78347845
Multiple-drug resistance 67.73 11.34 25 1220887 8783 78514693
Chronic obstructive pulmonary disease 67.31 11.34 1749 1219163 83670 78439806
Breast cancer stage I 67.02 11.34 11 1220901 6689 78516787
Miosis 66.86 11.34 86 1220826 15703 78507773
Cardiovascular disorder 66.73 11.34 489 1220423 17536 78505940
Dizziness 66.68 11.34 9115 1211797 517326 78006150
Encephalopathy 65.86 11.34 686 1220226 66711 78456765
Cardiac disorder 65.84 11.34 1392 1219520 64365 78459111
Colorectal cancer 65.72 11.34 25 1220887 8622 78514854
Septic shock 65.65 11.34 1406 1219506 121395 78402081
Toxic skin eruption 65.57 11.34 153 1220759 22140 78501336
Tumour lysis syndrome 65.16 11.34 171 1220741 23768 78499708
Thrombocytopenia 65.13 11.34 3357 1217555 261902 78261574
Premature delivery 63.95 11.34 594 1220318 22873 78500603
Vomiting 63.85 11.34 9079 1211833 656749 77866727
Occult blood positive 62.92 11.34 240 1220672 6643 78516833
BK virus infection 62.79 11.34 28 1220884 8776 78514700
Agitation 62.63 11.34 1111 1219801 98604 78424872
Retroperitoneal haemorrhage 62.27 11.34 205 1220707 5265 78518211
Chronic graft versus host disease 61.77 11.34 14 1220898 6767 78516709
Haematoma 61.71 11.34 1133 1219779 51062 78472414
Anaphylactic shock 61.63 11.34 312 1220600 35684 78487792
Cystitis haemorrhagic 61.11 11.34 32 1220880 9140 78514336
Joint swelling 60.98 11.34 5172 1215740 283474 78240002
Device difficult to use 60.83 11.34 69 1220843 13316 78510160
Urticaria 60.69 11.34 2270 1218642 182931 78340545
Aplasia 60.46 11.34 22 1220890 7798 78515678
Exposure via ingestion 60.40 11.34 5 1220907 5169 78518307
Device use error 60.18 11.34 17 1220895 7084 78516392
Arthralgia 59.52 11.34 9791 1211121 562012 77961464
Blood pressure systolic increased 59.48 11.34 1394 1219518 65592 78457884
Hepatitis B reactivation 58.98 11.34 11 1220901 6097 78517379
International normalised ratio increased 58.37 11.34 1705 1219207 83016 78440460
Transplant rejection 58.30 11.34 132 1220780 19305 78504171
Multiple injuries 58.13 11.34 150 1220762 3345 78520131
Anti-cyclic citrullinated peptide antibody positive 58.04 11.34 1676 1219236 81467 78442009
Irritability 57.89 11.34 380 1220532 40764 78482712
Hyperthermia 57.83 11.34 118 1220794 17919 78505557
Metastases to liver 57.11 11.34 231 1220681 28083 78495393
Pericarditis 56.34 11.34 2038 1218874 102198 78421278
No adverse event 56.20 11.34 336 1220576 36856 78486620
Multiple sclerosis relapse 56.18 11.34 449 1220463 46084 78477392
Paradoxical drug reaction 55.91 11.34 20 1220892 7165 78516311
Synovitis 55.80 11.34 2833 1218079 147901 78375575
Shunt occlusion 55.71 11.34 90 1220822 1414 78522062
Drug interaction 55.54 11.34 5537 1215375 409646 78113830
Peripheral arterial occlusive disease 55.34 11.34 262 1220650 7996 78515480
Fatigue 54.90 11.34 15495 1205417 914232 77609244
Pain in extremity 54.48 11.34 6377 1214535 358161 78165315
Disseminated intravascular coagulation 54.06 11.34 324 1220588 35518 78487958
Duodenal ulcer haemorrhage 53.78 11.34 235 1220677 6928 78516548
Helicobacter infection 53.69 11.34 1423 1219489 68281 78455195
Second primary malignancy 53.05 11.34 86 1220826 14264 78509212
Hospitalisation 53.00 11.34 1070 1219842 93166 78430310
Peripheral vascular disorder 52.53 11.34 253 1220659 7777 78515699
Brain oedema 51.65 11.34 205 1220707 25058 78498418
Temperature regulation disorder 51.52 11.34 13 1220899 5840 78517636
Acute generalised exanthematous pustulosis 51.08 11.34 118 1220794 17136 78506340
Abnormal behaviour 50.93 11.34 337 1220575 36084 78487392
Flushing 50.61 11.34 999 1219913 87269 78436207
Stent placement 50.55 11.34 216 1220696 6304 78517172
Nausea 50.01 11.34 13468 1207444 943728 77579748
Aggression 49.65 11.34 519 1220393 50439 78473037
Full blood count decreased 49.47 11.34 628 1220284 26191 78497285
Angiopathy 49.16 11.34 227 1220685 6855 78516621
Aortic valve stenosis 48.73 11.34 185 1220727 5109 78518367
Respiratory failure 48.58 11.34 2268 1218644 178643 78344833
Oedema peripheral 48.41 11.34 4489 1216423 247799 78275677
Eosinophilia 48.30 11.34 452 1220460 44893 78478583
Blood urea increased 48.25 11.34 1031 1219881 47759 78475717
Acute hepatic failure 48.21 11.34 267 1220645 29846 78493630
Migraine 47.85 11.34 998 1219914 86495 78436981
Intraventricular haemorrhage 47.67 11.34 174 1220738 4713 78518763
Graft versus host disease in skin 47.10 11.34 17 1220895 6056 78517420
Hiatus hernia 46.95 11.34 555 1220357 22757 78500719
Polyomavirus-associated nephropathy 46.72 11.34 14 1220898 5613 78517863
Osteoarthritis 46.68 11.34 1705 1219207 85604 78437872
Duodenitis 46.47 11.34 243 1220669 7724 78515752
Osteonecrosis of jaw 46.42 11.34 430 1220482 42796 78480680
Lymphopenia 45.68 11.34 277 1220635 30280 78493196
Headache 45.60 11.34 9073 1211839 644699 77878777
Cytomegalovirus infection reactivation 45.26 11.34 40 1220872 8676 78514800
Device issue 45.26 11.34 237 1220675 26871 78496605
Hyperbilirubinaemia 45.18 11.34 207 1220705 24311 78499165
Heart rate decreased 45.18 11.34 1403 1219509 68913 78454563
Pseudomonas infection 45.07 11.34 166 1220746 20737 78502739
Vascular pseudoaneurysm 44.95 11.34 137 1220775 3373 78520103
Venoocclusive disease 44.66 11.34 8 1220904 4565 78518911
Pneumocystis jirovecii pneumonia 44.35 11.34 303 1220609 32205 78491271
Ventricular dysfunction 44.00 11.34 196 1220716 5827 78517649
Hyperprolactinaemia 43.93 11.34 9 1220903 4667 78518809
Hypercalcaemia 43.63 11.34 829 1220083 37601 78485875
Blood loss anaemia 43.60 11.34 395 1220517 15103 78508373
Blood prolactin abnormal 43.40 11.34 3 1220909 3598 78519878
Localised infection 43.15 11.34 812 1220100 36763 78486713
Intercepted product preparation error 42.81 11.34 3 1220909 3557 78519919
Disturbance in attention 42.62 11.34 535 1220377 50266 78473210
Tricuspid valve incompetence 42.25 11.34 475 1220437 19237 78504239
Psychomotor hyperactivity 41.69 11.34 126 1220786 16723 78506753
Femur fracture 41.58 11.34 827 1220085 37825 78485651
Spinal osteoarthritis 41.47 11.34 419 1220493 16508 78506968
Retroperitoneal haematoma 41.47 11.34 176 1220736 5121 78518355
Discomfort 41.30 11.34 2335 1218577 123282 78400194
Acute respiratory distress syndrome 41.25 11.34 453 1220459 43614 78479862
Therapeutic product effect incomplete 40.41 11.34 1764 1219148 139881 78383595
Disturbance in social behaviour 40.12 11.34 13 1220899 4957 78518519
Human herpesvirus 6 infection 40.03 11.34 16 1220896 5354 78518122
Erythema 39.98 11.34 2910 1218002 220380 78303096
Hypoxia 39.97 11.34 1239 1219673 102004 78421472
Complication of device insertion 39.65 11.34 24 1220888 6326 78517150
Gastrooesophageal reflux disease 39.54 11.34 1964 1218948 102282 78421194
Viral mutation identified 39.35 11.34 6 1220906 3852 78519624
Bradyphrenia 39.11 11.34 64 1220848 10576 78512900
Cerebrovascular disorder 38.78 11.34 135 1220777 3570 78519906
Skin toxicity 38.72 11.34 42 1220870 8272 78515204
Metastases to central nervous system 38.72 11.34 125 1220787 16250 78507226
Cytomegalovirus chorioretinitis 38.32 11.34 18 1220894 5472 78518004
Blood pressure diastolic decreased 38.23 11.34 663 1220249 29553 78493923
Hypertension 37.96 11.34 5699 1215213 325293 78198183
Dilatation atrial 37.94 11.34 134 1220778 3570 78519906
Uterine perforation 37.74 11.34 25 1220887 6278 78517198
Diffuse large B-cell lymphoma recurrent 37.70 11.34 9 1220903 4198 78519278
Bradypnoea 37.61 11.34 23 1220889 6029 78517447
Electrocardiogram abnormal 37.56 11.34 407 1220505 16330 78507146
Acute graft versus host disease in intestine 37.51 11.34 8 1220904 4033 78519443
Pneumatosis intestinalis 37.46 11.34 26 1220886 6371 78517105
Aortic stenosis 37.30 11.34 219 1220693 7276 78516200
Blood pressure increased 37.17 11.34 3738 1217174 207622 78315854
Hyperammonaemia 36.92 11.34 71 1220841 11022 78512454
Hallucination, auditory 36.78 11.34 177 1220735 20516 78502960
Myoclonus 36.66 11.34 260 1220652 27400 78496076
Haemorrhagic stroke 36.60 11.34 292 1220620 10754 78512722
Transplant dysfunction 36.47 11.34 34 1220878 7187 78516289
Carotid artery disease 36.46 11.34 96 1220816 2168 78521308
Mania 36.18 11.34 150 1220762 18110 78505366
Aortic valve incompetence 36.12 11.34 260 1220652 9270 78514206
Cardiac murmur 36.07 11.34 386 1220526 15438 78508038
Intermittent claudication 35.92 11.34 126 1220786 3345 78520131
Electrocardiogram ST segment elevation 35.92 11.34 236 1220676 8161 78515315
Anosognosia 35.87 11.34 7 1220905 3757 78519719
Sinus node dysfunction 35.76 11.34 221 1220691 7480 78515996
Catatonia 35.74 11.34 49 1220863 8707 78514769
Metastases to bone 35.69 11.34 223 1220689 24204 78499272
Non-cardiac chest pain 35.61 11.34 259 1220653 9265 78514211
Diastolic dysfunction 35.39 11.34 285 1220627 10526 78512950
Accidental death 35.04 11.34 11 1220901 4280 78519196
Respiratory distress 34.44 11.34 657 1220255 57682 78465794
Angioedema 34.35 11.34 1458 1219454 74577 78448899
Metastases to lung 34.28 11.34 152 1220760 18011 78505465
Extrapyramidal disorder 34.21 11.34 205 1220707 22474 78501002
Dermatitis acneiform 34.10 11.34 63 1220849 9930 78513546
Device dislocation 33.99 11.34 245 1220667 25725 78497751
Device leakage 33.98 11.34 72 1220840 10784 78512692
Post procedural complication 33.90 11.34 533 1220379 23296 78500180
Virologic failure 33.77 11.34 11 1220901 4180 78519296
Haemorrhoids 33.63 11.34 630 1220282 28498 78494978
Spinal stenosis 33.61 11.34 380 1220532 15411 78508065
Transaminases increased 33.61 11.34 573 1220339 51170 78472306
Subarachnoid haemorrhage 33.59 11.34 544 1220368 23921 78499555
Hepatic cytolysis 33.23 11.34 261 1220651 26890 78496586
Heparin-induced thrombocytopenia 33.21 11.34 258 1220654 9424 78514052
Heart rate irregular 33.10 11.34 693 1220219 31986 78491490
Duodenal ulcer perforation 32.99 11.34 1283 1219629 64928 78458548
Adjustment disorder 32.96 11.34 135 1220777 3865 78519611
Nasopharyngitis 32.94 11.34 4403 1216509 249478 78273998
Muscular weakness 32.81 11.34 2873 1218039 157856 78365620
Device related infection 32.71 11.34 351 1220561 33943 78489533
Benign prostatic hyperplasia 32.69 11.34 296 1220616 11316 78512160
Breast cancer stage II 32.59 11.34 46 1220866 8074 78515402
Device breakage 32.42 11.34 72 1220840 10603 78512873
Aortic aneurysm 32.34 11.34 231 1220681 8215 78515261
Hypercholesterolaemia 32.26 11.34 515 1220397 22580 78500896
Acute lymphocytic leukaemia recurrent 32.19 11.34 16 1220896 4708 78518768
Post procedural haemorrhage 32.14 11.34 337 1220575 13407 78510069
Blood creatinine increased 32.02 11.34 2774 1218138 152283 78371193
Aortic arteriosclerosis 31.91 11.34 240 1220672 8678 78514798
Klebsiella infection 31.86 11.34 128 1220784 15592 78507884
Candida infection 31.85 11.34 403 1220509 37811 78485665
Large intestine polyp 31.82 11.34 316 1220596 12392 78511084
Epilepsy 31.82 11.34 437 1220475 40423 78483053
Psychotic disorder 31.82 11.34 444 1220468 40958 78482518
Metastases to lymph nodes 31.68 11.34 70 1220842 10327 78513149
Bundle branch block left 31.66 11.34 292 1220620 11221 78512255
Respiratory disorder 31.36 11.34 490 1220422 44366 78479110
Reye's syndrome 31.34 11.34 13 1220899 16 78523460
Pericardial haemorrhage 31.14 11.34 144 1220768 4351 78519125
Disability assessment scale score increased 31.14 11.34 120 1220792 3338 78520138
Diverticulum intestinal 31.03 11.34 232 1220680 8373 78515103
Hyperthermia malignant 31.01 11.34 4 1220908 2913 78520563
Accidental overdose 30.94 11.34 423 1220489 39158 78484318
Anaemia 30.85 11.34 7470 1213442 437545 78085931
Helicobacter gastritis 30.82 11.34 95 1220817 2354 78521122
Abortion incomplete 30.72 11.34 5 1220907 3059 78520417
Cataract 30.55 11.34 1202 1219710 60918 78462558
Red blood cell sedimentation rate abnormal 30.24 11.34 470 1220442 20493 78502983
Aplastic anaemia 30.19 11.34 156 1220756 17749 78505727
Strongyloidiasis 30.08 11.34 11 1220901 3887 78519589
Ventricular extrasystoles 30.06 11.34 446 1220466 19258 78504218
Cytopenia 29.83 11.34 186 1220726 20197 78503279
Coagulation time abnormal 29.70 11.34 26 1220886 202 78523274
Hypertransaminasaemia 29.62 11.34 89 1220823 11835 78511641
Thrombotic thrombocytopenic purpura 29.62 11.34 183 1220729 6193 78517283
Nocardiosis 29.56 11.34 26 1220886 5653 78517823
Coronary angioplasty 29.52 11.34 34 1220878 379 78523097
Diabetic foot 29.47 11.34 122 1220790 3510 78519966
Electrocardiogram Q wave abnormal 29.44 11.34 42 1220870 588 78522888
Cardiotoxicity 29.24 11.34 93 1220819 12146 78511330
Psychiatric decompensation 29.23 11.34 12 1220900 3951 78519525
Carotid artery thrombosis 29.19 11.34 108 1220804 2945 78520531
Restlessness 29.19 11.34 518 1220394 45974 78477502
Body temperature increased 29.15 11.34 491 1220421 43929 78479547
Anaphylactic reaction 29.09 11.34 1019 1219893 82724 78440752
Prostate cancer stage I 29.01 11.34 3 1220909 2594 78520882
Neurologic neglect syndrome 28.78 11.34 104 1220808 2803 78520673
Appendicitis 28.77 11.34 193 1220719 20601 78502875
Ischaemia 28.72 11.34 217 1220695 7858 78515618
Blood pressure fluctuation 28.66 11.34 1280 1219632 65865 78457611
Face oedema 28.47 11.34 284 1220628 27852 78495624
Psychomotor skills impaired 28.46 11.34 23 1220889 5214 78518262
Deafness transitory 28.31 11.34 53 1220859 942 78522534
Epistaxis 28.26 11.34 2027 1218885 109488 78413988
Blood creatine phosphokinase increased 28.23 11.34 1260 1219652 64830 78458646
Post procedural haematoma 28.23 11.34 92 1220820 2350 78521126
Small intestinal haemorrhage 27.84 11.34 132 1220780 4031 78519445
Hemiparesis 27.83 11.34 695 1220217 33038 78490438
Bacteraemia 27.79 11.34 345 1220567 32479 78490997
Delirium 27.76 11.34 1037 1219875 83590 78439886
Increased tendency to bruise 27.58 11.34 263 1220649 10201 78513275
Drug level increased 27.43 11.34 434 1220478 39217 78484259
Cardiomegaly 27.40 11.34 561 1220351 25791 78497685
Oesophageal carcinoma 27.34 11.34 83 1220829 11001 78512475
Fungal infection 27.22 11.34 462 1220450 41286 78482190
Hypocalcaemia 27.18 11.34 977 1219935 48947 78474529
Oculogyric crisis 27.08 11.34 6 1220906 2946 78520530
Pneumonia aspiration 27.06 11.34 799 1220113 66168 78457308
Alcohol interaction 27.00 11.34 21 1220891 4853 78518623
Complication of device removal 26.76 11.34 13 1220899 3876 78519600
Breast cancer female 26.74 11.34 88 1220824 11373 78512103
Myalgia 26.55 11.34 3239 1217673 182402 78341074
Blood creatine phosphokinase MB increased 26.51 11.34 99 1220813 2712 78520764
Percutaneous coronary intervention 26.46 11.34 32 1220880 377 78523099
Hepatitis B 26.30 11.34 55 1220857 8277 78515199
Pneumonia fungal 26.21 11.34 86 1220826 11124 78512352
Affective disorder 26.18 11.34 55 1220857 8264 78515212
Leukoencephalopathy 26.17 11.34 51 1220861 7878 78515598
Product monitoring error 26.09 11.34 229 1220683 8677 78514799
Polyneuropathy 26.04 11.34 240 1220672 23911 78499565
Food allergy 26.03 11.34 82 1220830 10742 78512734
Bacterial infection 26.02 11.34 330 1220582 30950 78492526
Forced expiratory volume decreased 26.02 11.34 50 1220862 7764 78515712
Subdural haemorrhage 25.95 11.34 168 1220744 5780 78517696
Enterocolitis 25.87 11.34 124 1220788 14388 78509088
Swelling 25.85 11.34 3740 1217172 212971 78310505
Weight decreased 25.59 11.34 5973 1214939 349225 78174251
Extraocular muscle disorder 25.56 11.34 28 1220884 294 78523182
Intervertebral disc degeneration 25.55 11.34 361 1220551 15424 78508052
Ventricular tachycardia 25.44 11.34 831 1220081 41104 78482372
Feeling hot 25.33 11.34 708 1220204 59026 78464450
Anxiety 25.32 11.34 3375 1217537 245137 78278339
Carotid bruit 25.20 11.34 44 1220868 739 78522737
Rheumatoid factor positive 25.16 11.34 1139 1219773 58700 78464776
Systemic candida 24.97 11.34 40 1220872 6666 78516810
Sudden cardiac death 24.93 11.34 151 1220761 5074 78518402
Recalled product 24.92 11.34 49 1220863 905 78522571
Red blood cell count decreased 24.90 11.34 1098 1219814 56415 78467061
Left ventricular failure 24.85 11.34 240 1220672 9341 78514135
Calciphylaxis 24.82 11.34 119 1220793 3651 78519825
Accidental exposure to product by child 24.81 11.34 7 1220905 2919 78520557
Gout 24.79 11.34 524 1220388 24225 78499251
Traumatic intracranial haemorrhage 24.74 11.34 57 1220855 1180 78522296
Metabolic acidosis 24.74 11.34 1022 1219890 81507 78441969
Metabolic disorder 24.58 11.34 66 1220846 9104 78514372
Diverticulum intestinal haemorrhagic 24.55 11.34 124 1220788 3887 78519589
Arterial occlusive disease 24.55 11.34 217 1220695 8239 78515237
Psoriatic arthropathy 24.50 11.34 1444 1219468 76555 78446921
Drug dose omission by device 24.50 11.34 36 1220876 6214 78517262
Renal cancer 24.50 11.34 100 1220812 12126 78511350
Arterial restenosis 24.33 11.34 15 1220897 62 78523414
Gastrointestinal ulcer 24.32 11.34 111 1220801 3335 78520141
Musculoskeletal discomfort 24.30 11.34 433 1220479 19402 78504074
Aortic valve sclerosis 24.24 11.34 71 1220841 1709 78521767
Knee arthroplasty 24.20 11.34 849 1220063 42399 78481077
Behaviour disorder 24.13 11.34 37 1220875 6276 78517200
Prostate cancer stage IV 24.07 11.34 4 1220908 2410 78521066
Helicobacter test positive 23.90 11.34 59 1220853 1279 78522197
Blood prolactin increased 23.89 11.34 16 1220896 3995 78519481
Cell death 23.88 11.34 22 1220890 4677 78518799
Progressive multifocal leukoencephalopathy 23.85 11.34 201 1220711 20399 78503077
Peptic ulcer 23.71 11.34 170 1220742 6053 78517423
Hypoalbuminaemia 23.67 11.34 210 1220702 21087 78502389
Genital haemorrhage 23.58 11.34 37 1220875 6218 78517258
Hepatic enzyme increased 23.55 11.34 3166 1217746 179444 78344032
Mood altered 23.53 11.34 168 1220744 17679 78505797
Hemiplegia 23.52 11.34 340 1220572 14599 78508877
Lipodystrophy acquired 23.50 11.34 19 1220893 4306 78519170
Joint effusion 23.42 11.34 397 1220515 17617 78505859
Hepatocellular carcinoma 23.38 11.34 66 1220846 8955 78514521
Aneurysm 23.36 11.34 112 1220800 3436 78520040
Atrial flutter 23.36 11.34 463 1220449 21162 78502314
Caesarean section 23.32 11.34 294 1220618 12241 78511235
Asthma 23.30 11.34 1766 1219146 133329 78390147
Neutropenic colitis 23.23 11.34 32 1220880 5675 78517801
Cerebral infarction 23.21 11.34 887 1220025 44789 78478687
Ischaemic stroke 23.15 11.34 668 1220244 32463 78491013
Treatment failure 23.11 11.34 2271 1218641 168215 78355261
Blood pressure diastolic abnormal 23.11 11.34 418 1220494 18784 78504692
Product preparation error 23.07 11.34 33 1220879 5760 78517716
Alcohol abuse 22.93 11.34 29 1220883 5334 78518142
Pelvic pain 22.89 11.34 116 1220796 13265 78510211
International normalised ratio decreased 22.86 11.34 206 1220706 7864 78515612
Immune effector cell-associated neurotoxicity syndrome 22.62 11.34 34 1220878 5814 78517662
Live birth 22.54 11.34 408 1220504 18336 78505140
Cholelithiasis 22.48 11.34 1004 1219908 51660 78471816
Clostridium difficile colitis 22.45 11.34 353 1220559 31930 78491546
Blood pressure systolic abnormal 22.39 11.34 380 1220532 16867 78506609
Vascular graft occlusion 22.26 11.34 40 1220872 688 78522788
Mitral valve calcification 22.25 11.34 61 1220851 1412 78522064
Toxic epidermal necrolysis 22.22 11.34 516 1220396 44065 78479411
Hyponatraemia 22.21 11.34 2383 1218529 175465 78348011
Cerebellar haemorrhage 22.07 11.34 96 1220816 2824 78520652
Urinary tract infection 22.06 11.34 4640 1216272 269872 78253604
Product quality issue 21.99 11.34 376 1220536 33564 78489912
Hepatic encephalopathy 21.99 11.34 250 1220662 23916 78499560
Cerebral ischaemia 21.87 11.34 265 1220647 10930 78512546
Psychotic symptom 21.87 11.34 7 1220905 2690 78520786
Gastric cancer 21.84 11.34 81 1220831 10098 78513378
Hepatitis C 21.78 11.34 101 1220811 11824 78511652
Hepatotoxicity 21.68 11.34 609 1220303 50743 78472733
Muscle haemorrhage 21.68 11.34 168 1220744 6132 78517344
Metabolic alkalosis 21.59 11.34 130 1220782 4359 78519117
Ecchymosis 21.58 11.34 340 1220572 14866 78508610
Bradykinesia 21.48 11.34 58 1220854 7985 78515491
Systemic mycosis 21.48 11.34 7 1220905 2659 78520817
Generalised tonic-clonic seizure 21.40 11.34 510 1220402 43400 78480076
Thrombotic stroke 21.37 11.34 40 1220872 711 78522765
Therapy interrupted 21.36 11.34 344 1220568 30997 78492479
Spinal epidural haematoma 21.33 11.34 59 1220853 1373 78522103
Basal cell carcinoma 21.24 11.34 735 1220177 36640 78486836
Arterial stenosis 21.23 11.34 59 1220853 1377 78522099
Cardiac arrest 21.08 11.34 2309 1218603 169787 78353689
Sinus bradycardia 21.07 11.34 521 1220391 24726 78498750
Juvenile idiopathic arthritis 21.07 11.34 135 1220777 4628 78518848
Rectal polyp 21.05 11.34 65 1220847 1612 78521864
Hip arthroplasty 21.03 11.34 706 1220206 35050 78488426
Arthritis 20.95 11.34 2037 1218875 112843 78410633
Coronary artery aneurysm 20.95 11.34 18 1220894 136 78523340
Occult blood 20.91 11.34 66 1220846 1657 78521819
Mediastinal haematoma 20.88 11.34 21 1220891 198 78523278
Acute myeloid leukaemia recurrent 20.83 11.34 13 1220899 3370 78520106
Muscle rigidity 20.82 11.34 199 1220713 19683 78503793
Vitreous haemorrhage 20.80 11.34 112 1220800 3601 78519875
Product administered to patient of inappropriate age 20.79 11.34 33 1220879 5520 78517956
Haemodialysis 20.65 11.34 392 1220520 17776 78505700
Hypogammaglobulinaemia 20.64 11.34 115 1220797 12836 78510640
Hypothermia 20.43 11.34 236 1220676 22510 78500966
Propofol infusion syndrome 20.42 11.34 3 1220909 1980 78521496
Puncture site haemorrhage 20.37 11.34 35 1220877 580 78522896
Sleep terror 20.24 11.34 23 1220889 4435 78519041
Nocturia 20.22 11.34 308 1220604 13373 78510103
Product dose omission issue 20.19 11.34 3406 1217506 244131 78279345
Amenorrhoea 20.14 11.34 56 1220856 7636 78515840
Paranoia 20.14 11.34 195 1220717 19237 78504239
Sinus arrest 20.12 11.34 109 1220803 3513 78519963
Pneumonia cytomegaloviral 20.09 11.34 28 1220884 4941 78518535
Chronic kidney disease 20.08 11.34 1221 1219691 64933 78458543
Splenic rupture 20.03 11.34 82 1220830 2347 78521129
Malignant melanoma 19.95 11.34 327 1220585 14414 78509062
Rotator cuff syndrome 19.94 11.34 315 1220597 13780 78509696
Inappropriate antidiuretic hormone secretion 19.93 11.34 283 1220629 26030 78497446
Stevens-Johnson syndrome 19.89 11.34 452 1220460 38714 78484762
Epstein-Barr virus associated lymphoproliferative disorder 19.84 11.34 15 1220897 3517 78519959
Gastrointestinal toxicity 19.81 11.34 61 1220851 8048 78515428
Pulmonary calcification 19.77 11.34 29 1220883 417 78523059
Wrong patient received product 19.71 11.34 25 1220887 4593 78518883
Catheter site haematoma 19.71 11.34 27 1220885 363 78523113
Page kidney 19.70 11.34 13 1220899 62 78523414
Aortic valve disease 19.69 11.34 70 1220842 1871 78521605
Eye haemorrhage 19.52 11.34 232 1220680 9525 78513951
Erosive duodenitis 19.50 11.34 74 1220838 2043 78521433
Dermatitis exfoliative generalised 19.50 11.34 52 1220860 7189 78516287
Drug effective for unapproved indication 19.46 11.34 39 1220873 5962 78517514
Blood calcium increased 19.38 11.34 244 1220668 10156 78513320
Tendonitis 19.37 11.34 490 1220422 23340 78500136
Coronary artery insufficiency 19.31 11.34 19 1220893 174 78523302
Embolic stroke 19.31 11.34 194 1220718 7632 78515844
Basal ganglia infarction 19.27 11.34 34 1220878 576 78522900
Oesophagitis haemorrhagic 19.23 11.34 36 1220876 640 78522836
Joint laxity 19.22 11.34 79 1220833 2265 78521211
Pain 19.19 11.34 11422 1209490 692380 77831096
Ventricular hypokinesia 19.17 11.34 222 1220690 9057 78514419
Mitochondrial toxicity 19.12 11.34 12 1220900 3102 78520374
Pancreatic carcinoma stage IV 19.12 11.34 5 1220907 2193 78521283
Pre-eclampsia 19.07 11.34 178 1220734 6863 78516613
Hip fracture 19.03 11.34 611 1220301 30150 78493326
Abortion spontaneous 19.01 11.34 589 1220323 28918 78494558
Depressive symptom 18.95 11.34 44 1220868 6379 78517097
Dyspnoea exertional 18.95 11.34 1564 1219348 85509 78437967
Encephalitis 18.95 11.34 140 1220772 14620 78508856
Pruritus 18.88 11.34 5572 1215340 389076 78134400
Blood homocysteine increased 18.82 11.34 28 1220884 408 78523068
Diabetes insipidus 18.79 11.34 32 1220880 5205 78518271
Cardiac tamponade 18.75 11.34 221 1220691 9055 78514421
Oesophageal ulcer 18.73 11.34 176 1220736 6799 78516677
Syringe issue 18.70 11.34 43 1220869 6255 78517221
Sputum increased 18.65 11.34 26 1220886 4587 78518889
Rebound effect 18.63 11.34 53 1220859 7173 78516303
Low density lipoprotein increased 18.58 11.34 208 1220704 8414 78515062
Hypokalaemia 18.52 11.34 1926 1218986 142114 78381362
Shock 18.50 11.34 516 1220396 43032 78480444
Arterial haemorrhage 18.45 11.34 83 1220829 2478 78520998
Troponin increased 18.43 11.34 405 1220507 18850 78504626
Extradural haematoma 18.37 11.34 90 1220822 2786 78520690
Silent myocardial infarction 18.33 11.34 37 1220875 697 78522779
Cardiac aneurysm 18.28 11.34 58 1220854 1460 78522016
Myopathy 18.27 11.34 428 1220484 20135 78503341
Myocardial rupture 18.24 11.34 21 1220891 234 78523242
Wrong technique in device usage process 18.05 11.34 21 1220891 4007 78519469
Mallory-Weiss syndrome 18.04 11.34 89 1220823 2763 78520713
Pericardial rub 18.04 11.34 8 1220904 13 78523463
Enterococcal infection 18.04 11.34 153 1220759 15507 78507969
Nicotine dependence 18.01 11.34 43 1220869 912 78522564
Breast cancer stage IV 18.00 11.34 4 1220908 1960 78521516
Proteinuria 17.98 11.34 370 1220542 32132 78491344
Varicella zoster virus infection 17.98 11.34 25 1220887 4416 78519060
Psoriasis 17.91 11.34 1599 1219313 87988 78435488
Dyskinesia 17.89 11.34 535 1220377 44238 78479238
Skin flap necrosis 17.87 11.34 10 1220902 33 78523443
Electrocardiogram ST segment depression 17.86 11.34 132 1220780 4746 78518730
Vascular graft complication 17.85 11.34 17 1220895 149 78523327
Asthenia 17.84 11.34 8367 1212545 503322 78020154
Cardiac stress test abnormal 17.83 11.34 39 1220873 779 78522697
Platelet aggregation increased 17.69 11.34 15 1220897 111 78523365
Renal haemorrhage 17.69 11.34 75 1220837 2181 78521295
Naevus flammeus 17.69 11.34 13 1220899 76 78523400
Pneumomediastinum 17.67 11.34 18 1220894 3649 78519827
Corneal oedema 17.66 11.34 9 1220903 2611 78520865
High density lipoprotein decreased 17.64 11.34 127 1220785 4528 78518948
Gastrointestinal arteriovenous malformation 17.62 11.34 43 1220869 925 78522551
Otitis media staphylococcal 17.62 11.34 7 1220905 7 78523469
Acute graft versus host disease in liver 17.62 11.34 4 1220908 1931 78521545
Persecutory delusion 17.61 11.34 30 1220882 4879 78518597
Type V hyperlipidaemia 17.59 11.34 45 1220867 998 78522478
Paronychia 17.50 11.34 61 1220851 7747 78515729
Fungaemia 17.46 11.34 27 1220885 4564 78518912
Vertebral artery stenosis 17.40 11.34 18 1220894 176 78523300
Coronary artery surgery 17.32 11.34 18 1220894 177 78523299
Cerebral arteriosclerosis 17.30 11.34 38 1220874 761 78522715
Normal newborn 17.30 11.34 175 1220737 6897 78516579
Hypertensive heart disease 17.26 11.34 117 1220795 4089 78519387
Fracture delayed union 17.22 11.34 71 1220841 2039 78521437
Intracranial aneurysm 17.17 11.34 124 1220788 4426 78519050
Chromaturia 17.15 11.34 516 1220396 25230 78498246
Supraventricular extrasystoles 17.14 11.34 173 1220739 6814 78516662
Steroid diabetes 17.13 11.34 17 1220895 3489 78519987
Platelet dysfunction 17.13 11.34 27 1220885 415 78523061
Anion gap 17.09 11.34 6 1220906 2175 78521301
Peripheral swelling 17.04 11.34 4508 1216404 265109 78258367
Osteoporosis 17.04 11.34 1002 1219910 53110 78470366
Platelet function test abnormal 17.02 11.34 18 1220894 181 78523295
Cross sensitivity reaction 17.02 11.34 19 1220893 3693 78519783
Right ventricular failure 17.00 11.34 255 1220657 23242 78500234
Swollen tongue 16.97 11.34 806 1220106 41764 78481712
Carotid arteriosclerosis 16.89 11.34 83 1220829 2573 78520903
Gastrointestinal angiodysplasia 16.88 11.34 45 1220867 1024 78522452
Coronary ostial stenosis 16.85 11.34 17 1220895 161 78523315
Injection site pain 16.84 11.34 1735 1219177 128103 78395373
Impaired healing 16.83 11.34 1560 1219352 86095 78437381
Myelodysplastic syndrome 16.75 11.34 345 1220567 29956 78493520
Diffuse large B-cell lymphoma 16.69 11.34 113 1220799 12036 78511440
Hungry bone syndrome 16.65 11.34 18 1220894 186 78523290
Enthesopathy 16.65 11.34 260 1220652 11348 78512128
Hepatojugular reflux 16.58 11.34 33 1220879 615 78522861
Generalised oedema 16.57 11.34 259 1220653 23450 78500026
Peripheral sensory neuropathy 16.55 11.34 124 1220788 12909 78510567
Vascular device infection 16.51 11.34 91 1220821 10185 78513291
Mitral valve prolapse 16.49 11.34 70 1220842 2037 78521439
Device malfunction 16.48 11.34 230 1220682 21218 78502258
Systolic dysfunction 16.44 11.34 107 1220805 3688 78519788
Mood swings 16.44 11.34 210 1220702 19670 78503806
Galactorrhoea 16.35 11.34 19 1220893 3627 78519849
Torsade de pointes 16.34 11.34 203 1220709 19109 78504367
Embedded device 16.33 11.34 16 1220896 3303 78520173
Rib deformity 16.28 11.34 19 1220893 215 78523261
Polyarthritis 16.26 11.34 270 1220642 11932 78511544
Calcification metastatic 16.24 11.34 15 1220897 126 78523350
Arterial stent insertion 16.22 11.34 13 1220899 88 78523388
Depression 16.21 11.34 2997 1217915 213793 78309683
Left ventricular hypertrophy 16.18 11.34 251 1220661 10940 78512536
Polycythaemia vera 16.12 11.34 24 1220888 350 78523126
Meningitis cryptococcal 16.01 11.34 18 1220894 3488 78519988
Prostate cancer stage II 16.00 11.34 7 1220905 2219 78521257
Haemorrhagic cholecystitis 16 11.34 13 1220899 90 78523386
Cardiac valve disease 15.99 11.34 146 1220766 5595 78517881
Rash morbilliform 15.94 11.34 45 1220867 6105 78517371
Musculoskeletal stiffness 15.88 11.34 2976 1217936 172032 78351444
Tenderness 15.79 11.34 474 1220438 23168 78500308
Renal cyst 15.77 11.34 315 1220597 14417 78509059
Coronary artery reocclusion 15.74 11.34 16 1220896 153 78523323
Insomnia 15.71 11.34 3416 1217496 241754 78281722
Blindness transient 15.69 11.34 126 1220786 4650 78518826
Terminal state 15.66 11.34 32 1220880 4857 78518619
Obsessive-compulsive disorder 15.63 11.34 43 1220869 5884 78517592
Atrioventricular block 15.63 11.34 302 1220610 13739 78509737
Haemorrhagic transformation stroke 15.62 11.34 82 1220830 2610 78520866
Prostate cancer stage III 15.62 11.34 4 1220908 1779 78521697
Viral haemorrhagic cystitis 15.60 11.34 6 1220906 2055 78521421
Coordination abnormal 15.59 11.34 361 1220551 16951 78506525
Drug abuser 15.58 11.34 44 1220868 5969 78517507
Vanishing bile duct syndrome 15.55 11.34 4 1220908 1774 78521702
Erosive oesophagitis 15.52 11.34 86 1220826 2796 78520680
Bicytopenia 15.45 11.34 30 1220882 4640 78518836
Congenital hiatus hernia 15.43 11.34 37 1220875 787 78522689
Choroidal dystrophy 15.42 11.34 10 1220902 46 78523430
Graft thrombosis 15.42 11.34 26 1220886 424 78523052
Premature rupture of membranes 15.41 11.34 111 1220801 3958 78519518
Pregnancy with contraceptive device 15.37 11.34 20 1220892 3634 78519842
Adrenal insufficiency 15.26 11.34 326 1220586 28161 78495315
Skin ulcer 15.25 11.34 993 1219919 53157 78470319
Anaemia postoperative 15.24 11.34 63 1220849 1811 78521665
Urinary bladder haemorrhage 15.24 11.34 78 1220834 2458 78521018
Dementia Alzheimer's type 15.20 11.34 42 1220870 977 78522499
Blood glucose decreased 15.18 11.34 517 1220395 25717 78497759
Liver abscess 15.17 11.34 45 1220867 6009 78517467
Peripheral artery aneurysm 15.17 11.34 26 1220886 430 78523046
Abdominal wall haematoma 15.17 11.34 127 1220785 4746 78518730
Diverticulitis intestinal haemorrhagic 15.16 11.34 27 1220885 461 78523015
Mental disorder 15.13 11.34 364 1220548 30938 78492538
Coronary artery perforation 15.12 11.34 12 1220900 80 78523396
Otitis media bacterial 15.10 11.34 6 1220906 6 78523470
Tetany 15.09 11.34 82 1220830 2646 78520830
Eye excision 15.00 11.34 12 1220900 81 78523395
Renal tubular disorder 15.00 11.34 50 1220862 6436 78517040
Respiratory acidosis 14.98 11.34 105 1220807 11095 78512381
Hallucination 14.92 11.34 1120 1219792 84625 78438851
Coeliac disease 14.89 11.34 107 1220805 11244 78512232
Cerebral artery occlusion 14.89 11.34 59 1220853 1663 78521813
Analgesic drug level increased 14.86 11.34 16 1220896 3162 78520314
Tenosynovitis 14.84 11.34 327 1220585 15227 78508249
Laryngeal pain 14.81 11.34 151 1220761 5963 78517513
Latent tuberculosis 14.81 11.34 95 1220817 3258 78520218
Barrett's oesophagus 14.80 11.34 36 1220876 773 78522703
Stress fracture 14.74 11.34 158 1220754 6322 78517154
Atrioventricular block first degree 14.71 11.34 271 1220641 12220 78511256
Pharyngeal haemorrhage 14.70 11.34 49 1220863 1267 78522209
Bronchospasm 14.66 11.34 280 1220632 24579 78498897
Bacterial sepsis 14.64 11.34 70 1220842 8128 78515348
Back disorder 14.63 11.34 254 1220658 11324 78512152
Electrocardiogram ST-T change 14.62 11.34 56 1220856 1553 78521923
Metastases to peritoneum 14.53 11.34 28 1220884 4344 78519132
Twin pregnancy 14.44 11.34 38 1220874 858 78522618
Obliterative bronchiolitis 14.43 11.34 15 1220897 3013 78520463
Fusarium infection 14.43 11.34 5 1220907 1827 78521649
Myositis 14.38 11.34 390 1220522 18778 78504698
Peritonitis bacterial 14.38 11.34 216 1220696 9351 78514125
Coronary artery embolism 14.36 11.34 21 1220891 301 78523175
Glomerular filtration rate increased 14.34 11.34 46 1220866 1165 78522311
Myocarditis 14.33 11.34 240 1220672 21493 78501983
Procedural complication 14.33 11.34 186 1220726 7797 78515679
Costochondritis 14.31 11.34 75 1220837 2386 78521090
Inappropriate schedule of product administration 14.30 11.34 1809 1219103 131819 78391657
Hyperhidrosis 14.29 11.34 2067 1218845 149425 78374051
Nephrocalcinosis 14.25 11.34 53 1220859 1449 78522027
Skin plaque 14.24 11.34 101 1220811 10644 78512832
Type 1 diabetes mellitus 14.24 11.34 56 1220856 6863 78516613
Cardiac operation 14.23 11.34 128 1220784 4884 78518592
Pneumonia viral 14.23 11.34 82 1220830 9076 78514400
Foot fracture 14.22 11.34 439 1220473 21542 78501934
Lung disorder 14.21 11.34 1051 1219861 79506 78443970
Basilar artery thrombosis 14.21 11.34 23 1220889 362 78523114
Arteriogram coronary abnormal 14.21 11.34 6 1220906 8 78523468
Panic attack 14.20 11.34 273 1220639 23943 78499533
Limb injury 14.20 11.34 570 1220342 28958 78494518
Shunt thrombosis 14.17 11.34 15 1220897 151 78523325
Hypernatraemia 14.15 11.34 147 1220765 14304 78509172
Blood HIV RNA increased 14.13 11.34 5 1220907 1803 78521673
Gastritis haemorrhagic 14.11 11.34 79 1220833 2578 78520898
Diarrhoea 14.06 11.34 12873 1208039 867616 77655860
Vascular stent occlusion 14.04 11.34 18 1220894 226 78523250
Sexual dysfunction 14.03 11.34 66 1220846 7697 78515779
Spinal disorder 14.03 11.34 228 1220684 10032 78513444
Eructation 14.03 11.34 240 1220672 10669 78512807
Tremor 14.00 11.34 2339 1218573 167744 78355732
Hypertriglyceridaemia 13.99 11.34 126 1220786 12614 78510862
Gastric cancer stage IV 13.99 11.34 3 1220909 1507 78521969
Palmoplantar keratoderma 13.99 11.34 22 1220890 3694 78519782
Lymphadenopathy 13.99 11.34 669 1220243 52578 78470898
Cardiospasm 13.96 11.34 18 1220894 3283 78520193
Cytomegalovirus enterocolitis 13.96 11.34 4 1220908 1651 78521825
Nephropathy toxic 13.96 11.34 224 1220688 20195 78503281
Hyperammonaemic encephalopathy 13.92 11.34 33 1220879 4749 78518727
Product substitution issue 13.91 11.34 222 1220690 20034 78503442
Pneumonia bacterial 13.91 11.34 210 1220702 19121 78504355
Skin laceration 13.91 11.34 559 1220353 28403 78495073
Vascular dementia 13.88 11.34 37 1220875 842 78522634
Hereditary angioedema 13.85 11.34 39 1220873 5296 78518180
Drug screen positive 13.84 11.34 47 1220865 6016 78517460
Oesophageal intramural haematoma 13.82 11.34 13 1220899 112 78523364
Electrocardiogram QRS complex prolonged 13.79 11.34 103 1220809 10730 78512746
Lichen planopilaris 13.78 11.34 9 1220903 42 78523434
Agonal rhythm 13.78 11.34 11 1220901 74 78523402
Clonus 13.67 11.34 56 1220856 6784 78516692
Lung neoplasm 13.67 11.34 167 1220745 6902 78516574
Cystic fibrosis 13.65 11.34 24 1220888 3856 78519620
Gestational diabetes 13.65 11.34 152 1220760 6141 78517335
Brain abscess 13.63 11.34 35 1220877 4901 78518575
Neck deformity 13.59 11.34 60 1220852 1777 78521699
Sinus tachycardia 13.54 11.34 446 1220466 36462 78487014
Intestinal pseudo-obstruction 13.51 11.34 12 1220900 2597 78520879
Spinal cord herniation 13.44 11.34 6 1220906 10 78523466
Disinhibition 13.40 11.34 12 1220900 2586 78520890
Atrioventricular block second degree 13.39 11.34 171 1220741 7141 78516335
Oesophagitis 13.39 11.34 476 1220436 23813 78499663
Hyperpyrexia 13.39 11.34 48 1220864 6044 78517432
Large intestinal ulcer 13.36 11.34 122 1220790 4675 78518801
Dieulafoy's vascular malformation 13.36 11.34 8 1220904 31 78523445
Hernia 13.35 11.34 349 1220563 16710 78506766
Device interaction 13.32 11.34 33 1220879 717 78522759
Heart valve stenosis 13.31 11.34 15 1220897 163 78523313
Vascular calcification 13.22 11.34 42 1220870 1058 78522418
Peritoneal dialysis complication 13.18 11.34 71 1220841 2283 78521193
Infusion site pain 13.16 11.34 146 1220766 14030 78509446
Neoplasm recurrence 13.15 11.34 28 1220884 4186 78519290
Ulcer haemorrhage 13.12 11.34 142 1220770 5696 78517780
Acute chest syndrome 13.11 11.34 53 1220859 1508 78521968
Pain in jaw 13.10 11.34 575 1220337 45576 78477900
Maternal exposure before pregnancy 13.10 11.34 113 1220799 4260 78519216
Open reduction of fracture 13.09 11.34 18 1220894 243 78523233
Gastric ulcer perforation 13.06 11.34 66 1220846 2069 78521407
Brain stem infarction 13.06 11.34 63 1220849 1938 78521538
Antipsychotic drug level increased 13.05 11.34 47 1220865 5910 78517566
Diffuse large B-cell lymphoma refractory 13.00 11.34 3 1220909 1432 78522044
Anaemia macrocytic 12.98 11.34 137 1220775 5460 78518016
Haemorrhage urinary tract 12.96 11.34 73 1220839 2388 78521088
Aneurysm ruptured 12.94 11.34 38 1220874 916 78522560
Metastases to meninges 12.92 11.34 22 1220890 3579 78519897
Iron deficiency anaemia 12.91 11.34 498 1220414 25174 78498302
Stress cardiomyopathy 12.90 11.34 109 1220803 11057 78512419
Enterobacter infection 12.87 11.34 32 1220880 4530 78518946
Rhinitis perennial 12.86 11.34 21 1220891 333 78523143
Joint injury 12.86 11.34 595 1220317 30740 78492736
Blood pressure inadequately controlled 12.86 11.34 148 1220764 6029 78517447
Diabetic ketoacidosis 12.84 11.34 411 1220501 33711 78489765
Angiogram abnormal 12.81 11.34 8 1220904 34 78523442
Pericardial disease 12.81 11.34 28 1220884 559 78522917
Joint destruction 12.80 11.34 143 1220769 5782 78517694
Blood cholesterol increased 12.80 11.34 1467 1219445 82253 78441223
Excessive eye blinking 12.79 11.34 5 1220907 1696 78521780
Skin haemorrhage 12.77 11.34 256 1220656 11725 78511751
Lactic acidosis 12.73 11.34 916 1219996 69443 78454033
Hypersensitivity myocarditis 12.72 11.34 18 1220894 250 78523226
Intentional product use issue 12.72 11.34 2090 1218822 150022 78373454
Bone disorder 12.71 11.34 383 1220529 18730 78504746
Colonic haematoma 12.71 11.34 11 1220901 84 78523392
Vitamin B12 deficiency 12.70 11.34 168 1220744 7073 78516403
Ventricular asystole 12.67 11.34 19 1220893 279 78523197
Engraftment syndrome 12.65 11.34 3 1220909 1406 78522070
Somnambulism 12.62 11.34 45 1220867 5676 78517800
Nasal obstruction 12.62 11.34 66 1220846 2098 78521378
Oral allergy syndrome 12.61 11.34 11 1220901 85 78523391
QRS axis abnormal 12.61 11.34 64 1220848 2010 78521466
Antinuclear antibody positive 12.59 11.34 180 1220732 7710 78515766
Flap necrosis 12.58 11.34 5 1220907 5 78523471
Lumbar spinal stenosis 12.58 11.34 130 1220782 5152 78518324
Gastrointestinal ulcer haemorrhage 12.58 11.34 46 1220866 1247 78522229
Retinal artery occlusion 12.56 11.34 90 1220822 3204 78520272
Dementia 12.56 11.34 479 1220433 24180 78499296
Nephrogenic systemic fibrosis 12.56 11.34 147 1220765 6013 78517463
Crying 12.55 11.34 263 1220649 22780 78500696
Compartment syndrome 12.55 11.34 126 1220786 4956 78518520
Haptoglobin increased 12.53 11.34 16 1220896 200 78523276
Small intestine polyp 12.53 11.34 7 1220905 23 78523453
Colitis 12.52 11.34 959 1219953 72348 78451128
Carotid artery occlusion 12.42 11.34 175 1220737 7472 78516004
Computerised tomogram coronary artery abnormal 12.42 11.34 16 1220896 202 78523274
Cognitive disorder 12.38 11.34 912 1220000 69014 78454462
Extremity contracture 12.38 11.34 56 1220856 1676 78521800
Unintended pregnancy 12.38 11.34 26 1220886 3907 78519569
Feeling of despair 12.33 11.34 15 1220897 2806 78520670
Post procedural drainage 12.32 11.34 9 1220903 52 78523424
Tardive dyskinesia 12.30 11.34 103 1220809 10468 78513008
Rotator cuff repair 12.29 11.34 59 1220853 1811 78521665
Vasoplegia syndrome 12.29 11.34 23 1220889 3607 78519869
Subclavian artery stenosis 12.28 11.34 17 1220895 231 78523245
Erythema multiforme 12.28 11.34 193 1220719 17458 78506018
Granulomatous pneumonitis 12.22 11.34 11 1220901 89 78523387
Complications of transplanted kidney 12.18 11.34 53 1220859 6313 78517163
Diverticulitis 12.16 11.34 838 1220074 45098 78478378
Aortic valve replacement 12.14 11.34 46 1220866 1269 78522207
Carpal tunnel syndrome 12.11 11.34 388 1220524 19140 78504336
Cerebral toxoplasmosis 12.07 11.34 11 1220901 2351 78521125
Nephrogenic diabetes insipidus 12.07 11.34 9 1220903 2125 78521351
Dyspnoea 12.07 11.34 13685 1207227 843340 77680136
Pseudomonal sepsis 12.06 11.34 51 1220861 6123 78517353
Prescription drug used without a prescription 12.04 11.34 28 1220884 4057 78519419
Gene mutation 12.04 11.34 14 1220898 2672 78520804
Ventricle rupture 12.04 11.34 11 1220901 91 78523385
Ileus paralytic 11.99 11.34 92 1220820 9528 78513948
Multiple fractures 11.98 11.34 181 1220731 7845 78515631
Device use issue 11.96 11.34 15 1220897 2769 78520707
Foetal growth restriction 11.93 11.34 64 1220848 2055 78521421
Mycobacterium chelonae infection 11.90 11.34 12 1220900 2444 78521032
Leukaemia recurrent 11.86 11.34 15 1220897 2759 78520717
Hepatitis fulminant 11.84 11.34 64 1220848 7198 78516278
HELLP syndrome 11.80 11.34 33 1220879 773 78522703
Fulminant type 1 diabetes mellitus 11.76 11.34 4 1220908 1479 78521997
Long QT syndrome 11.75 11.34 49 1220863 5906 78517570
Infection reactivation 11.75 11.34 14 1220898 2643 78520833
Gamma-glutamyltransferase increased 11.74 11.34 701 1220211 53979 78469497
Mitral valve stenosis 11.73 11.34 43 1220869 1167 78522309
Essential hypertension 11.70 11.34 143 1220769 5910 78517566
Fat embolism 11.69 11.34 23 1220889 425 78523051
Depersonalisation/derealisation disorder 11.68 11.34 7 1220905 1855 78521621
Thrombolysis 11.66 11.34 17 1220895 243 78523233
Red blood cells urine positive 11.65 11.34 38 1220874 4925 78518551
Body temperature decreased 11.65 11.34 603 1220309 31542 78491934
Haemorrhagic infarction 11.64 11.34 32 1220880 742 78522734
Ulcer 11.63 11.34 566 1220346 29406 78494070
Tongue haematoma 11.63 11.34 16 1220896 216 78523260
Therapy non-responder 11.62 11.34 1236 1219676 91069 78432407
Body tinea 11.59 11.34 7 1220905 1847 78521629
Blood pressure systolic decreased 11.58 11.34 236 1220676 10840 78512636
Stenosis 11.56 11.34 70 1220842 2352 78521124
Thalamus haemorrhage 11.55 11.34 56 1220856 1726 78521750
Joint noise 11.55 11.34 102 1220810 3872 78519604
Dependence 11.54 11.34 12 1220900 2410 78521066
Post procedural myocardial infarction 11.54 11.34 8 1220904 42 78523434
Type I hypersensitivity 11.53 11.34 32 1220880 4366 78519110
Hand-eye coordination impaired 11.52 11.34 7 1220905 28 78523448
Vascular procedure complication 11.52 11.34 7 1220905 28 78523448
Dactylitis 11.50 11.34 77 1220835 2680 78520796
Capillary leak syndrome 11.49 11.34 27 1220885 3898 78519578
Wrist fracture 11.49 11.34 251 1220661 11670 78511806
Differentiation syndrome 11.48 11.34 13 1220899 2511 78520965
Device physical property issue 11.48 11.34 14 1220898 2616 78520860
Gangrene 11.45 11.34 197 1220715 8767 78514709
Drug-induced liver injury 11.44 11.34 864 1220048 65253 78458223
Liver function test abnormal 11.42 11.34 1141 1219771 63334 78460142
Myocardial necrosis marker increased 11.41 11.34 87 1220825 3159 78520317
Middle insomnia 11.41 11.34 175 1220737 15894 78507582
Salivary gland calculus 11.41 11.34 17 1220895 248 78523228
Vascular occlusion 11.41 11.34 50 1220862 1476 78522000
Intracranial haematoma 11.40 11.34 36 1220876 904 78522572
Tooth disorder 11.39 11.34 501 1220411 25732 78497744
Coronary artery dissection 11.39 11.34 41 1220871 1103 78522373
Puncture site reaction 11.37 11.34 6 1220906 17 78523459
Deep vein thrombosis 11.36 11.34 2060 1218852 118859 78404617
Foetal distress syndrome 11.34 11.34 24 1220888 468 78523008

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AC01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Calcium compounds
ATC A12AA04 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:65265 antacids
CHEBI has role CHEBI:77182 food coloring
CHEBI has role CHEBI:77960 firming agents
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Indigestion indication 162031009
Heartburn Prevention indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
H0G9379FGK UNII
4019035 VUID
N0000147306 NUI
4017644 VANDF
4019033 VANDF
4019035 VANDF
C0006681 UMLSCUI
CHEBI:3311 CHEBI
CHEMBL1200539 ChEMBL_ID
10112 PUBCHEM_CID
DB06724 DRUGBANK_ID
D002119 MESH_DESCRIPTOR_UI
1897 RXNORM
10153 MMSL
41410 MMSL
4326 MMSL
4330 MMSL
6070 MMSL
d00425 MMSL
000773 NDDF
001117 NDDF
387307005 SNOMEDCT_US
55217007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0054-3117 SUSPENSION 1250 mg ORAL OTC monograph final 11 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0054-3117 SUSPENSION 1250 mg ORAL OTC monograph final 11 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
good sense antacid HUMAN OTC DRUG LABEL 1 0113-0962 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 11 sections
good sense antacid HUMAN OTC DRUG LABEL 1 0113-0962 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 11 sections
injoy heartburn relief HUMAN OTC DRUG LABEL 3 0113-6023 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
injoy heartburn relief HUMAN OTC DRUG LABEL 3 0113-6023 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
basic care dual action complete HUMAN OTC DRUG LABEL 3 0113-7321 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
basic care dual action complete HUMAN OTC DRUG LABEL 3 0113-7321 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
PHAZYME HUMAN OTC DRUG LABEL 2 0132-0507 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 11 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0070 TABLET 500 mg ORAL OTC monograph final 12 sections