calcium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4239 471-34-1

Description:

MoleculeDescription

Synonyms:

  • calcium carbonate
  • carbonic acid calcium salt
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
  • Molecular weight: 100.09
  • Formula: CCaO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 2000 FDA MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1171.10 10.96 300 784341 131589 49688894
Toxicity to various agents 637.30 10.96 1474 783167 211025 49609458
Myocardial infarction 624.29 10.96 2886 781755 86141 49734342
Drug abuse 594.56 10.96 105 784536 59741 49760742
Off label use 458.14 10.96 4927 779714 469499 49350984
Coronary artery disease 454.45 10.96 1246 783395 28480 49792003
Cerebrovascular accident 438.30 10.96 2739 781902 91941 49728542
Cardiac failure congestive 388.60 10.96 2438 782203 81944 49738539
Acute myocardial infarction 366.83 10.96 1143 783498 28130 49792353
Febrile neutropenia 339.40 10.96 622 784019 97045 49723438
Pemphigus 337.83 10.96 3091 781550 117075 49703408
Device expulsion 312.89 10.96 39 784602 28783 49791700
Drug ineffective 311.76 10.96 10015 774626 809318 49011165
Systemic lupus erythematosus 293.22 10.96 3403 781238 137219 49683264
Intentional overdose 274.30 10.96 339 784302 62165 49758318
Death 268.30 10.96 3496 781145 321883 49498600
Glossodynia 262.80 10.96 2845 781796 112724 49707759
Gastrointestinal haemorrhage 239.97 10.96 1951 782690 71370 49749113
Malignant neoplasm progression 228.58 10.96 443 784198 67681 49752802
Product use in unapproved indication 211.93 10.96 998 783643 114821 49705662
Suicide attempt 211.20 10.96 296 784345 51436 49769047
Drug hypersensitivity 204.85 10.96 2702 781939 248308 49572175
Transient ischaemic attack 197.37 10.96 1005 783636 31205 49789278
Abdominal discomfort 185.49 10.96 4803 779838 226838 49593645
Milk-alkali syndrome 181.59 10.96 120 784521 565 49819918
Overdose 175.08 10.96 872 783769 98855 49721628
Hand deformity 161.47 10.96 2313 782328 97886 49722597
Arthropathy 159.79 10.96 3383 781258 154523 49665960
Coronary arterial stent insertion 149.14 10.96 194 784447 2440 49818043
Intentional self-injury 148.24 10.96 87 784554 23025 49797458
Maternal exposure during pregnancy 147.67 10.96 3379 781262 156399 49664084
Wound 141.33 10.96 2366 782275 103428 49717055
Angina unstable 140.38 10.96 317 784324 6389 49814094
Haemoglobin decreased 137.04 10.96 2751 781890 124465 49696018
Rheumatoid arthritis 132.01 10.96 4092 780549 198458 49622025
Sopor 127.26 10.96 75 784566 19804 49800679
No adverse event 126.50 10.96 203 784438 33375 49787108
Alopecia 120.49 10.96 4793 779848 240254 49580229
Plasma cell myeloma 117.18 10.96 860 783781 30462 49790021
Disease progression 115.86 10.96 940 783701 94926 49725557
Drug reaction with eosinophilia and systemic symptoms 112.68 10.96 166 784475 28258 49792225
Coronary artery bypass 111.74 10.96 157 784484 2136 49818347
Drug resistance 111.53 10.96 79 784562 18910 49801573
Drug dependence 109.88 10.96 87 784554 19672 49800811
Neutropenia 109.76 10.96 1623 783018 146342 49674141
Pyrexia 109.03 10.96 4802 779839 375401 49445082
Angina pectoris 100.82 10.96 724 783917 25464 49795019
Pericarditis 97.54 10.96 1739 782902 76950 49743533
Aspirin-exacerbated respiratory disease 95.85 10.96 91 784550 783 49819700
Intentional product misuse 93.71 10.96 389 784252 46345 49774138
Coronary artery occlusion 93.08 10.96 292 784349 7211 49813272
Respiratory arrest 90.68 10.96 207 784434 29802 49790681
Cytomegalovirus infection 90.30 10.96 87 784554 17875 49802608
Somnolence 88.18 10.96 1783 782858 153202 49667281
Drug withdrawal syndrome 87.71 10.96 159 784482 24922 49795561
Suicidal ideation 86.25 10.96 504 784137 54881 49765602
Discomfort 85.90 10.96 2245 782396 106135 49714348
Wrong technique in product usage process 84.93 10.96 508 784133 55002 49765481
Hospitalisation 81.22 10.96 668 783973 67269 49753214
Accidental exposure to product 79.89 10.96 147 784494 22910 49797573
Anti-cyclic citrullinated peptide antibody positive 79.51 10.96 1537 783104 69050 49751433
Full blood count decreased 78.75 10.96 605 784036 21741 49798742
Multiple sclerosis relapse 78.06 10.96 371 784270 42593 49777890
Thrombosis in device 77.92 10.96 147 784494 2594 49817889
Neoplasm progression 77.33 10.96 215 784426 28942 49791541
Urticaria 74.44 10.96 1488 783153 128073 49692410
Poisoning deliberate 74.09 10.96 16 784625 7896 49812587
Sedation 71.69 10.96 239 784402 30371 49790112
Poisoning 71.31 10.96 53 784588 12376 49808107
Electrocardiogram QT prolonged 71.12 10.96 491 784150 51395 49769088
Myocardial ischaemia 70.88 10.96 362 784279 11251 49809232
Fall 70.83 10.96 6071 778570 328861 49491622
Drug interaction 70.64 10.96 2459 782182 197162 49623321
Atrial fibrillation 69.25 10.96 2067 782574 99678 49720805
Hepatocellular injury 69.05 10.96 191 784450 25756 49794727
Cardio-respiratory arrest 69.02 10.96 520 784121 53372 49767111
Palmar-plantar erythrodysaesthesia syndrome 68.87 10.96 129 784512 19969 49800514
Respiratory depression 67.89 10.96 52 784589 11958 49808525
Coronary artery stenosis 66.74 10.96 181 784460 4108 49816375
Device dislocation 64.79 10.96 149 784492 21397 49799086
Serotonin syndrome 64.23 10.96 184 784457 24529 49795954
Device difficult to use 63.70 10.96 37 784604 9849 49810634
Cholestasis 63.21 10.96 193 784448 25208 49795275
Therapeutic product effect incomplete 62.67 10.96 1019 783622 90496 49729987
Haematotoxicity 60.97 10.96 23 784618 7872 49812611
Helicobacter infection 60.37 10.96 1095 783546 48607 49771876
Chest pain 60.04 10.96 3335 781306 173547 49646936
Unintentional medical device removal 59.86 10.96 7 784634 5428 49815055
Hip arthroplasty 58.31 10.96 725 783916 29704 49790779
Gastric ulcer 58.23 10.96 545 784096 20760 49799723
Neuroleptic malignant syndrome 58.20 10.96 52 784589 11078 49809405
Thrombosis 57.29 10.96 1199 783442 54634 49765849
Arteriosclerosis coronary artery 56.77 10.96 252 784389 7384 49813099
Febrile bone marrow aplasia 56.64 10.96 14 784627 6297 49814186
Tachycardia 56.32 10.96 1149 783492 98614 49721869
Respiratory disorder 56.25 10.96 270 784371 30917 49789566
Headache 56.15 10.96 6938 777703 499597 49320886
Anaphylactic reaction 55.24 10.96 553 784088 53502 49766981
Vascular stent thrombosis 54.69 10.96 69 784572 840 49819643
Carotid artery stenosis 54.04 10.96 179 784462 4552 49815931
Lacunar infarction 53.89 10.96 136 784505 2951 49817532
Hepatic failure 53.39 10.96 288 784353 31995 49788488
Coma 53.21 10.96 594 784047 56285 49764198
Asthma 53.12 10.96 1020 783621 88317 49732166
Complication of device insertion 53.06 10.96 14 784627 6027 49814456
Femur fracture 53.00 10.96 846 783795 36618 49783865
Device use error 52.81 10.96 9 784632 5257 49815226
Leukopenia 52.37 10.96 734 783907 66794 49753689
Acute myeloid leukaemia 52.32 10.96 96 784545 14978 49805505
Sickle cell anaemia with crisis 52.00 10.96 172 784469 4371 49816112
Vascular stent stenosis 51.97 10.96 51 784590 459 49820024
Coronary artery thrombosis 51.91 10.96 73 784568 994 49819489
Drug ineffective for unapproved indication 51.33 10.96 164 784477 21117 49799366
Metastases to bone 51.29 10.96 128 784513 17867 49802616
Encephalopathy 50.77 10.96 310 784331 33401 49787082
Duodenal ulcer perforation 50.28 10.96 990 783651 44621 49775862
Recalled product 50.21 10.96 81 784560 1254 49819229
Upper gastrointestinal haemorrhage 49.91 10.96 422 784219 15613 49804870
Nausea 49.72 10.96 9918 774723 695480 49125003
Toxic skin eruption 49.36 10.96 61 784580 11190 49809293
Swelling 49.35 10.96 3684 780957 197188 49623295
Synovitis 49.25 10.96 2371 782270 121494 49698989
Product quality issue 49.00 10.96 279 784362 30579 49789904
Duodenal ulcer 48.43 10.96 221 784420 6554 49813929
Knee arthroplasty 47.20 10.96 800 783841 35046 49785437
Myelosuppression 46.99 10.96 86 784555 13431 49807052
Lymphocyte count decreased 46.14 10.96 230 784411 26077 49794406
Anaphylactic shock 45.41 10.96 160 784481 19995 49800488
Muscle spasticity 45.35 10.96 127 784514 17057 49803426
Contusion 45.15 10.96 2150 782491 110033 49710450
Posterior reversible encephalopathy syndrome 45.07 10.96 103 784538 14825 49805658
Metastases to liver 45.02 10.96 160 784481 19944 49800539
Post transplant lymphoproliferative disorder 44.87 10.96 6 784635 4198 49816285
Depressed level of consciousness 44.57 10.96 553 784088 51400 49769083
Withdrawal syndrome 44.23 10.96 133 784508 17457 49803026
Gastritis erosive 44.05 10.96 177 784464 4957 49815526
Vomiting 44.05 10.96 6369 778272 454389 49366094
Device issue 43.37 10.96 161 784480 19811 49800672
Mydriasis 43.17 10.96 61 784580 10566 49809917
Insomnia 42.57 10.96 2246 782395 172619 49647864
Infective pulmonary exacerbation of cystic fibrosis 42.51 10.96 36 784605 7873 49812610
Ascites 42.22 10.96 354 784287 35507 49784976
Cataract 41.97 10.96 995 783646 46305 49774178
Mucosal inflammation 41.29 10.96 410 784231 39732 49780751
Graft versus host disease 41.29 10.96 22 784619 6144 49814339
Gastric ulcer haemorrhage 41.23 10.96 158 784483 4326 49816157
Anxiety 41.23 10.96 2292 782349 175314 49645169
Akathisia 41.20 10.96 40 784601 8189 49812294
Deafness transitory 41.10 10.96 88 784553 1708 49818775
Haematocrit decreased 40.88 10.96 766 783875 34210 49786273
Melaena 40.81 10.96 614 784027 26250 49794233
Coronary artery restenosis 40.74 10.96 38 784603 319 49820164
Rheumatoid factor positive 40.70 10.96 1037 783604 48822 49771661
Exposure during pregnancy 40.51 10.96 2279 782362 118736 49701747
Incorrect route of product administration 40.19 10.96 151 784490 18515 49801968
Retroperitoneal haemorrhage 39.91 10.96 108 784533 2448 49818035
Cytokine release syndrome 39.82 10.96 45 784596 8589 49811894
Haemophagocytic lymphohistiocytosis 39.81 10.96 45 784596 8588 49811895
Fatigue 39.78 10.96 11912 772729 695689 49124794
Agitation 39.38 10.96 586 784055 52798 49767685
Hepatic function abnormal 38.75 10.96 322 784319 32359 49788124
Uterine perforation 38.58 10.96 26 784615 6389 49814094
Bone marrow failure 38.55 10.96 260 784381 27364 49793119
Arteriosclerosis 37.90 10.96 256 784385 8821 49811662
Bronchopulmonary aspergillosis 37.90 10.96 37 784604 7555 49812928
Infusion related reaction 37.57 10.96 3085 781556 166472 49654011
Mitral valve incompetence 37.32 10.96 425 784216 17046 49803437
Irritability 37.00 10.96 273 784368 28153 49792330
Drug use disorder 36.34 10.96 3 784638 3069 49817414
Neurotoxicity 35.96 10.96 113 784528 14627 49805856
Complication of device removal 35.92 10.96 10 784631 4154 49816329
Metastases to central nervous system 35.58 10.96 76 784565 11206 49809277
Thrombocytopenia 35.12 10.96 1619 783022 126054 49694429
Acute graft versus host disease 35.09 10.96 9 784632 3949 49816534
Exposure to toxic agent 35.07 10.96 7 784634 3651 49816832
Seizure 34.62 10.96 1484 783157 116390 49704093
Dystonia 33.86 10.96 85 784556 11841 49808642
Multiple organ dysfunction syndrome 33.29 10.96 564 784077 49773 49770710
Thrombotic microangiopathy 33.25 10.96 53 784588 8738 49811745
Osteoarthritis 33.16 10.96 1340 783301 67266 49753217
Paradoxical drug reaction 32.90 10.96 8 784633 3639 49816844
Genital haemorrhage 32.86 10.96 32 784609 6542 49813941
Body temperature increased 32.70 10.96 319 784322 31022 49789461
Psoriasis 32.51 10.96 1344 783297 67656 49752827
Exposure via ingestion 32.44 10.96 3 784638 2800 49817683
Diverticulum 32.33 10.96 278 784363 10336 49810147
Pain 32.17 10.96 9742 774899 569161 49251322
Graft versus host disease in gastrointestinal tract 32.13 10.96 3 784638 2778 49817705
Cardiac arrest 31.76 10.96 1021 783620 82630 49737853
Epstein-Barr virus infection 31.69 10.96 37 784604 6960 49813523
Red blood cell sedimentation rate abnormal 31.14 10.96 389 784252 15954 49804529
Transplant dysfunction 30.94 10.96 17 784624 4667 49815816
Interstitial lung disease 30.73 10.96 610 784031 52566 49767917
Vascular graft 30.68 10.96 48 784593 723 49819760
Gastritis 30.23 10.96 697 783944 32286 49788197
Brain oedema 30.06 10.96 95 784546 12275 49808208
Temperature regulation disorder 29.93 10.96 14 784627 4213 49816270
Aspergillus infection 29.90 10.96 37 784604 6784 49813699
Second primary malignancy 29.80 10.96 38 784603 6876 49813607
Faeces discoloured 29.54 10.96 381 784260 15743 49804740
Ventricular hypertrophy 29.33 10.96 113 784528 3102 49817381
Erythema 29.27 10.96 1916 782725 144498 49675985
Graft versus host disease in skin 28.89 10.96 3 784638 2553 49817930
Acute coronary syndrome 28.80 10.96 246 784395 9128 49811355
Agranulocytosis 28.71 10.96 204 784437 21217 49799266
Hepatic enzyme increased 28.59 10.96 2488 782153 134892 49685591
Multiple-drug resistance 28.51 10.96 8 784633 3306 49817177
Pathogen resistance 28.08 10.96 28 784613 5661 49814822
Metastases to lung 27.94 10.96 83 784558 10937 49809546
Abortion incomplete 27.93 10.96 7 784634 3119 49817364
Joint swelling 27.80 10.96 4271 780370 241015 49579468
Migraine 27.59 10.96 923 783718 74357 49746126
Flushing 27.38 10.96 810 783831 66205 49754278
Hiatus hernia 27.37 10.96 418 784223 17926 49802557
Hyperprolactinaemia 27.36 10.96 9 784632 3356 49817127
Neutrophil count decreased 27.19 10.96 526 784115 45500 49774983
Human herpesvirus 6 infection 27.16 10.96 4 784637 2602 49817881
Device breakage 27.14 10.96 68 784573 9479 49811004
Mania 27.12 10.96 83 784558 10833 49809650
Hypertransaminasaemia 27.09 10.96 11 784630 3600 49816883
Polyneuropathy 26.86 10.96 97 784544 12034 49808449
Cardiac disorder 26.79 10.96 864 783777 42115 49778368
Pregnancy with contraceptive device 26.66 10.96 15 784626 4064 49816419
Chronic graft versus host disease 26.44 10.96 6 784635 2861 49817622
Rectal haemorrhage 26.12 10.96 783 783858 37775 49782708
Embedded device 26.04 10.96 6 784635 2831 49817652
Urinary tract infection 26.00 10.96 3906 780735 220114 49600369
Hypocalcaemia 25.93 10.96 571 784070 26245 49794238
Premature delivery 25.87 10.96 513 784128 23150 49797333
Miosis 25.85 10.96 36 784605 6274 49814209
Substance abuse 25.78 10.96 16 784625 4108 49816375
Shunt stenosis 25.76 10.96 32 784609 383 49820100
Therapy partial responder 25.63 10.96 39 784602 6552 49813931
Pericardial haemorrhage 25.21 10.96 64 784577 1394 49819089
Altered state of consciousness 25.02 10.96 218 784423 21692 49798791
Cerebral haemorrhage 24.90 10.96 572 784069 26480 49794003
Adenovirus infection 24.85 10.96 9 784632 3159 49817324
Status epilepticus 24.79 10.96 115 784526 13291 49807192
Hip fracture 24.71 10.96 551 784090 25380 49795103
Transplant rejection 24.63 10.96 72 784569 9537 49810946
Juvenile idiopathic arthritis 24.50 10.96 99 784542 2780 49817703
Blood calcium increased 24.47 10.96 204 784437 7515 49812968
Amenorrhoea 24.45 10.96 60 784581 8424 49812059
Acute generalised exanthematous pustulosis 24.38 10.96 65 784576 8873 49811610
Spinal stenosis 24.33 10.96 319 784322 13231 49807252
Ear pain 24.27 10.96 301 784340 27982 49792501
Acute hepatic failure 24.22 10.96 143 784498 15534 49804949
Immune reconstitution inflammatory syndrome 24.10 10.96 30 784611 5486 49814997
Disease recurrence 23.74 10.96 198 784443 19883 49800600
Caesarean section 23.58 10.96 357 784284 15282 49805201
Aplasia 23.55 10.96 15 784626 3798 49816685
Pruritus 23.42 10.96 3952 780689 279616 49540867
Tumour lysis syndrome 23.39 10.96 50 784591 7371 49813112
Blood urea increased 23.38 10.96 504 784137 23081 49797402
Accidental overdose 23.36 10.96 192 784449 19341 49801142
Bradyphrenia 23.35 10.96 37 784604 6115 49814368
Disability assessment scale score increased 23.27 10.96 85 784556 2273 49818210
Live birth 23.01 10.96 370 784271 16038 49804445
Eosinophilia 22.92 10.96 182 784459 18470 49802013
BK virus infection 22.91 10.96 8 784633 2873 49817610
Tooth disorder 22.83 10.96 514 784127 23714 49796769
Aortic valve stenosis 22.74 10.96 99 784542 2876 49817607
Catatonia 22.66 10.96 15 784626 3721 49816762
Haemorrhage intracranial 22.50 10.96 292 784349 12082 49808401
Cardiotoxicity 22.44 10.96 47 784594 6980 49813503
Laboratory test abnormal 22.39 10.96 494 784147 22714 49797769
Hypoxia 22.38 10.96 612 784029 50511 49769972
Pain in extremity 22.37 10.96 4672 779969 268193 49552290
Cytomegalovirus viraemia 22.31 10.96 24 784617 4685 49815798
Stent placement 22.28 10.96 109 784532 3329 49817154
Hepatitis B reactivation 22.23 10.96 3 784638 2084 49818399
Multiple injuries 22.20 10.96 67 784574 1619 49818864
Multiple fractures 22.19 10.96 177 784464 6434 49814049
Infusion site pain 22.19 10.96 107 784534 12239 49808244
Nasopharyngitis 22.16 10.96 3362 781279 189565 49630918
Vascular pseudoaneurysm 22.13 10.96 59 784582 1325 49819158
Disseminated intravascular coagulation 22.09 10.96 165 784476 16970 49803513
Heart rate decreased 22.05 10.96 731 783910 35766 49784717
Basal cell carcinoma 21.85 10.96 495 784146 22861 49797622
Cardiovascular disorder 21.74 10.96 253 784388 10201 49810282
Hallucination, auditory 21.68 10.96 89 784552 10639 49809844
Nephrocalcinosis 21.46 10.96 47 784594 927 49819556
Epilepsy 21.46 10.96 222 784419 21345 49799138
Premature labour 21.37 10.96 272 784369 11204 49809279
Restlessness 21.19 10.96 269 784372 24904 49795579
Extrapyramidal disorder 21.16 10.96 102 784539 11668 49808815
Pseudomonas infection 21.15 10.96 75 784566 9355 49811128
Disturbance in attention 21.09 10.96 348 784293 30838 49789645
Product preparation error 21.03 10.96 22 784619 4350 49816133
Haemorrhagic stroke 20.97 10.96 146 784495 5082 49815401
Gastrointestinal toxicity 20.90 10.96 25 784616 4652 49815831
Blood prolactin increased 20.83 10.96 11 784630 3088 49817395
Skin toxicity 20.80 10.96 18 784623 3895 49816588
Rash maculo-papular 20.50 10.96 290 784351 26351 49794132
Sleep disorder 20.36 10.96 705 783936 56578 49763905
Lower gastrointestinal haemorrhage 20.34 10.96 179 784462 6700 49813783
Retroperitoneal haematoma 20.24 10.96 88 784553 2555 49817928
Product adhesion issue 20.13 10.96 23 784618 4369 49816114
Food allergy 20.12 10.96 62 784579 8075 49812408
Ischaemic cardiomyopathy 20.07 10.96 80 784561 2232 49818251
Pneumonia viral 19.95 10.96 48 784593 6786 49813697
Peripheral vascular disorder 19.81 10.96 149 784492 5318 49815165
Hypercalcaemia 19.74 10.96 488 784153 22864 49797619
Psoriatic arthropathy 19.68 10.96 905 783736 46127 49774356
Carotid artery occlusion 19.67 10.96 84 784557 2419 49818064
Wrist fracture 19.62 10.96 268 784373 11219 49809264
Venoocclusive disease 19.55 10.96 3 784638 1893 49818590
Abnormal loss of weight 19.48 10.96 140 784501 4924 49815559
Mood altered 19.47 10.96 117 784524 12656 49807827
Mood swings 19.46 10.96 156 784485 15798 49804685
Angioedema 19.40 10.96 741 783900 36935 49783548
Peripheral arterial occlusive disease 19.36 10.96 107 784534 3430 49817053
Haematemesis 19.32 10.96 565 784076 27160 49793323
Joint laxity 19.25 10.96 81 784560 2317 49818166
Metastases to lymph nodes 19.22 10.96 51 784590 6973 49813510
Carotid artery thrombosis 19.21 10.96 59 784582 1440 49819043
Injection site haematoma 19.13 10.96 160 784481 5900 49814583
Osteonecrosis of jaw 19.13 10.96 372 784269 32154 49788329
Bradykinesia 18.79 10.96 20 784621 3923 49816560
Aggression 18.78 10.96 223 784418 20893 49799590
Spinal osteoarthritis 18.73 10.96 315 784326 13777 49806706
Device deployment issue 18.68 10.96 16 784625 3480 49817003
Gastrointestinal pain 18.59 10.96 199 784442 7857 49812626
Cystitis haemorrhagic 18.53 10.96 18 784623 3684 49816799
Acute lymphocytic leukaemia recurrent 18.48 10.96 4 784637 1971 49818512
Nightmare 18.39 10.96 160 784481 15926 49804557
Rhabdomyolysis 18.33 10.96 760 783881 38267 49782216
Contraindicated product administered 18.31 10.96 2606 782035 146352 49674131
Arthralgia 18.31 10.96 7305 777336 431397 49389086
Pre-eclampsia 18.24 10.96 198 784443 7846 49812637
Haemorrhage 18.17 10.96 1008 783633 52433 49768050
Duodenal ulcer haemorrhage 18.05 10.96 74 784567 2092 49818391
Lymphopenia 18.03 10.96 155 784486 15466 49805017
Lung neoplasm 18.02 10.96 144 784497 5238 49815245
Osteoporosis 18.01 10.96 860 783781 44019 49776464
Blood pressure systolic increased 17.97 10.96 696 783945 34753 49785730
Aortic stenosis 17.94 10.96 119 784522 4075 49816408
Cell death 17.88 10.96 6 784635 2209 49818274
Dilatation atrial 17.87 10.96 66 784575 1775 49818708
Hyperlipidaemia 17.74 10.96 375 784266 17115 49803368
Joint effusion 17.65 10.96 292 784349 12729 49807754
Shunt occlusion 17.65 10.96 30 784611 486 49819997
Aortic aneurysm 17.65 10.96 98 784543 3147 49817336
Occult blood positive 17.64 10.96 99 784542 3192 49817291
Coronary artery aneurysm 17.58 10.96 9 784632 23 49820460
Seasonal allergy 17.35 10.96 322 784319 14354 49806129
Infection 17.35 10.96 2383 782258 170571 49649912
Abnormal behaviour 17.33 10.96 208 784433 19450 49801033
Hypophosphataemic osteomalacia 17.24 10.96 17 784624 154 49820329
Carotid arteriosclerosis 17.18 10.96 43 784598 928 49819555
Swollen joint count increased 17.12 10.96 325 784316 14548 49805935
Maternal drugs affecting foetus 17.08 10.96 136 784505 4941 49815542
Disturbance in social behaviour 17.05 10.96 12 784629 2882 49817601
Device malfunction 17.02 10.96 151 784490 14970 49805513
Coeliac disease 16.97 10.96 73 784568 8612 49811871
Malignant melanoma 16.93 10.96 235 784406 9873 49810610
Skin laceration 16.91 10.96 397 784244 18445 49802038
Fracture delayed union 16.83 10.96 75 784566 2201 49818282
Face oedema 16.80 10.96 186 784455 17653 49802830
Bone disorder 16.79 10.96 395 784246 18357 49802126
Sinus node dysfunction 16.79 10.96 112 784529 3843 49816640
Arterial stenosis 16.78 10.96 31 784610 538 49819945
Blood pressure diastolic decreased 16.76 10.96 359 784282 16422 49804061
Persecutory delusion 16.76 10.96 8 784633 2379 49818104
Epstein-Barr virus associated lymphoproliferative disorder 16.69 10.96 3 784638 1686 49818797
Haematoma 16.66 10.96 604 784037 29906 49790577
Depression 16.62 10.96 2279 782362 163144 49657339
Humerus fracture 16.58 10.96 186 784455 7432 49813051
Galactorrhoea 16.53 10.96 20 784621 3703 49816780
Myoclonus 16.51 10.96 144 784497 14326 49806157
Blood loss anaemia 16.49 10.96 196 784445 7943 49812540
Tetany 16.48 10.96 59 784582 1562 49818921
Chronic obstructive pulmonary disease 16.47 10.96 999 783642 52436 49768047
Red blood cell count decreased 16.38 10.96 661 783980 33174 49787309
Incorrect product administration duration 16.32 10.96 81 784560 9194 49811289
Rheumatic fever 16.26 10.96 359 784282 16508 49803975
Electrocardiogram ST-T change 16.23 10.96 43 784598 962 49819521
Salivary gland calculus 16.22 10.96 16 784625 145 49820338
Device related infection 16.20 10.96 225 784416 20510 49799973
Schizoaffective disorder 16.10 10.96 7 784634 2199 49818284
Cerebral infarction 16.09 10.96 444 784197 21160 49799323
Coronary angioplasty 16.08 10.96 13 784628 88 49820395
Oesophagitis haemorrhagic 16.01 10.96 25 784616 376 49820107
Product substitution issue 15.99 10.96 140 784501 13917 49806566
Increased tendency to bruise 15.86 10.96 218 784423 9138 49811345
Drug level increased 15.81 10.96 207 784434 19061 49801422
Crying 15.79 10.96 222 784419 20194 49800289
Diabetic ketoacidosis 15.79 10.96 189 784452 17683 49802800
Dermatitis acneiform 15.78 10.96 24 784617 4033 49816450
Metabolic acidosis 15.67 10.96 470 784171 38355 49782128
Cerebrovascular disorder 15.48 10.96 80 784561 2498 49817985
Aortic valve incompetence 15.43 10.96 141 784500 5335 49815148
Acute respiratory distress syndrome 15.42 10.96 232 784409 20867 49799616
Accidental death 15.40 10.96 4 784637 1740 49818743
Non-cardiac chest pain 15.35 10.96 146 784495 5586 49814897
Labelled drug-drug interaction medication error 15.35 10.96 238 784403 10239 49810244
Sepsis 15.35 10.96 1815 782826 131110 49689373
Bradypnoea 15.32 10.96 15 784626 3059 49817424
Respiratory failure 15.32 10.96 1211 783430 89970 49730513
Rectourethral fistula 15.29 10.96 9 784632 33 49820450
Hereditary angioedema 15.28 10.96 39 784602 5403 49815080
Atrial septal defect 15.27 10.96 158 784483 6183 49814300
Neck deformity 15.25 10.96 66 784575 1912 49818571
Forced expiratory volume decreased 15.23 10.96 28 784613 4366 49816117
Electrocardiogram ST segment elevation 15.14 10.96 99 784542 3374 49817109
Platelet aggregation increased 15.13 10.96 7 784634 13 49820470
Localised infection 15.03 10.96 509 784132 24976 49795507
Reye's syndrome 15.03 10.96 6 784635 6 49820477
Muscle rigidity 15 10.96 90 784551 9739 49810744
Weight decreased 14.96 10.96 3755 780886 217490 49602993
Pelvic pain 14.92 10.96 107 784534 11106 49809377
Heparin-induced thrombocytopenia 14.90 10.96 109 784532 3856 49816627
Nicotine dependence 14.88 10.96 32 784609 623 49819860
Aortic arteriosclerosis 14.87 10.96 138 784503 5244 49815239
Hyperthermia 14.84 10.96 65 784576 7631 49812852
Carotid artery disease 14.79 10.96 55 784586 1484 49818999
Skin cancer 14.77 10.96 216 784425 9178 49811305
Cardiac valve disease 14.76 10.96 105 784536 3681 49816802
Post procedural haematoma 14.69 10.96 47 784594 1173 49819310
Blood iron abnormal 14.63 10.96 18 784623 3308 49817175
Ventricular septal defect 14.57 10.96 110 784531 3931 49816552
Diverticulitis 14.43 10.96 641 784000 32541 49787942
Hypothermia 14.42 10.96 118 784523 11898 49808585
Hypertension 14.41 10.96 3586 781055 207617 49612866
Klebsiella infection 14.34 10.96 60 784581 7134 49813349
Sexual dysfunction 14.28 10.96 18 784623 3274 49817209
Dyspnoea 14.26 10.96 8006 776635 539602 49280881
Unintended pregnancy 14.24 10.96 35 784606 4911 49815572
Gamma-glutamyltransferase increased 14.19 10.96 350 784291 29273 49791210
Vitello-intestinal duct remnant 14.18 10.96 9 784632 39 49820444
Implant site pain 14.14 10.96 8 784633 2161 49818322
Pulmonary toxicity 14.02 10.96 42 784599 5520 49814963
General physical health deterioration 13.98 10.96 1965 782676 140469 49680014
Intervertebral disc degeneration 13.78 10.96 289 784352 13172 49807311
Postoperative wound infection 13.77 10.96 196 784445 8279 49812204
Catheter site haematoma 13.77 10.96 14 784627 132 49820351
Shock 13.77 10.96 231 784410 20419 49800064
Tardive dyskinesia 13.72 10.96 62 784579 7217 49813266
Panic attack 13.69 10.96 214 784427 19128 49801355
Haptoglobin increased 13.68 10.96 9 784632 42 49820441
Dyskinesia 13.67 10.96 328 784313 27533 49792950
Ear infection 13.66 10.96 512 784129 25458 49795025
Transaminases increased 13.53 10.96 328 784313 27496 49792987
Twin pregnancy 13.52 10.96 43 784598 1070 49819413
Rib deformity 13.50 10.96 15 784626 158 49820325
Crohn's disease 13.40 10.96 122 784519 4611 49815872
Hyperbilirubinaemia 13.39 10.96 90 784551 9480 49811003
Aortic valve sclerosis 13.39 10.96 41 784600 999 49819484
Sinus arrest 13.36 10.96 57 784584 1641 49818842
Tricuspid valve incompetence 13.34 10.96 275 784366 12495 49807988
Heart rate irregular 13.34 10.96 394 784247 18966 49801517
Oculogyric crisis 13.27 10.96 3 784638 1434 49819049
Rebound effect 13.26 10.96 18 784623 3171 49817312
Liver function test increased 13.25 10.96 299 784342 25307 49795176
Blood iron increased 13.24 10.96 49 784592 1319 49819164
Cross sensitivity reaction 13.22 10.96 7 784634 1962 49818521
Affective disorder 13.15 10.96 39 784602 5142 49815341
Diverticulum intestinal haemorrhagic 13.13 10.96 45 784596 1165 49819318
Abdominal pain 13.11 10.96 3358 781283 232870 49587613
Neurologic neglect syndrome 13.10 10.96 51 784590 1407 49819076
Adjustment disorder 13.07 10.96 64 784577 1955 49818528
Latent tuberculosis 13.05 10.96 69 784572 2174 49818309
Virologic failure 13.04 10.96 4 784637 1560 49818923
Calcification metastatic 13.03 10.96 5 784636 4 49820479
Blood pressure increased 13.01 10.96 2300 782341 130832 49689651
Inappropriate schedule of product administration 13.01 10.96 948 783693 70883 49749600
Hepatic cytolysis 13.01 10.96 73 784568 8030 49812453
Vascular dementia 12.99 10.96 27 784614 513 49819970
Oedema peripheral 12.96 10.96 2705 781936 155256 49665227
Product storage error 12.93 10.96 124 784517 12100 49808383
Product administered to patient of inappropriate age 12.92 10.96 13 784628 2617 49817866
Body height decreased 12.91 10.96 202 784439 8706 49811777
Delirium 12.90 10.96 473 784168 37719 49782764
Wheezing 12.89 10.96 809 783832 61238 49759245
Hyperhidrosis 12.89 10.96 1202 783439 88224 49732259
Hypercalciuria 12.88 10.96 17 784624 217 49820266
Blood creatine phosphokinase MB increased 12.86 10.96 43 784598 1099 49819384
Intentional product use issue 12.85 10.96 1022 783619 75896 49744587
Aneurysm 12.83 10.96 74 784567 2411 49818072
Stress fracture 12.82 10.96 163 784478 6712 49813771
Ischaemia 12.80 10.96 112 784529 4185 49816298
Congenital hydronephrosis 12.77 10.96 23 784618 391 49820092
Pneumonia 12.77 10.96 6257 778384 372144 49448339
Device use issue 12.74 10.96 7 784634 1922 49818561
Suture removal 12.73 10.96 4 784637 0 49820483
Anticholinergic syndrome 12.63 10.96 6 784635 1789 49818694
Varicella zoster virus infection 12.58 10.96 12 784629 2477 49818006
Otitis media staphylococcal 12.52 10.96 5 784636 5 49820478
Otitis media bacterial 12.52 10.96 5 784636 5 49820478
Tremor 12.50 10.96 1575 783066 113328 49707155
Extraocular muscle disorder 12.49 10.96 12 784629 105 49820378
Neoplasm recurrence 12.47 10.96 11 784630 2358 49818125
Pelvic haematoma 12.44 10.96 26 784615 496 49819987
Eye excision 12.38 10.96 8 784633 36 49820447
Thrombotic stroke 12.30 10.96 25 784616 467 49820016
Acute graft versus host disease in intestine 12.28 10.96 5 784636 1634 49818849
Hypercholesterolaemia 12.22 10.96 252 784389 11451 49809032
Septic shock 12.14 10.96 744 783897 56431 49764052
Peritonitis bacterial 12.12 10.96 118 784523 4543 49815940
Hemiplegia 12.12 10.96 171 784470 7210 49813273
Embolic stroke 12.09 10.96 94 784547 3390 49817093
Large intestine polyp 12.09 10.96 170 784471 7162 49813321
Diverticulum intestinal 12.08 10.96 143 784498 5790 49814693
Dysphoria 12.07 10.96 36 784605 4738 49815745
Gastroenteritis viral 12.06 10.96 379 784262 18407 49802076
Heavy menstrual bleeding 12.00 10.96 169 784472 15368 49805115
Squamous cell carcinoma of skin 11.99 10.96 128 784513 5050 49815433
Soft tissue disorder 11.99 10.96 30 784611 4184 49816299
Haemodialysis 11.89 10.96 189 784452 8173 49812310
Duodenitis 11.80 10.96 89 784552 3179 49817304
Gastrooesophageal reflux disease 11.80 10.96 1356 783285 75072 49745411
Hepatitis C 11.78 10.96 38 784603 4879 49815604
Tenderness 11.77 10.96 374 784267 18191 49802292
Metastases to peritoneum 11.77 10.96 16 784625 2817 49817666
Congenital uterine anomaly 11.74 10.96 12 784629 114 49820369
Aspartate aminotransferase increased 11.73 10.96 1045 783596 76953 49743530
Arterial stent insertion 11.63 10.96 7 784634 27 49820456
Urinary retention 11.60 10.96 313 784328 25877 49794606
Rectal polyp 11.55 10.96 37 784604 924 49819559
Mitral valve calcification 11.55 10.96 37 784604 924 49819559
Renal artery stenosis 11.55 10.96 54 784587 1618 49818865
Hypokalaemia 11.53 10.96 1191 783450 86801 49733682
Diverticulitis intestinal haemorrhagic 11.50 10.96 12 784629 117 49820366
Peripheral ischaemia 11.49 10.96 109 784532 4167 49816316
Premature rupture of membranes 11.45 10.96 115 784526 4465 49816018
Iliac artery stenosis 11.44 10.96 7 784634 28 49820455
Musculoskeletal stiffness 11.43 10.96 2209 782432 126272 49694211
Shoulder arthroplasty 11.40 10.96 92 784549 3356 49817127
Antinuclear antibody positive 11.40 10.96 148 784493 6124 49814359
Metabolic alkalosis 11.39 10.96 77 784564 2654 49817829
Subdural haematoma 11.37 10.96 272 784369 12675 49807808
Haemorrhoids 11.35 10.96 381 784260 18672 49801811
Hypoacusis 11.33 10.96 409 784232 20238 49800245
Musculoskeletal discomfort 11.33 10.96 307 784334 14591 49805892
Ageusia 11.31 10.96 247 784394 11336 49809147
Menstruation irregular 11.31 10.96 53 784588 6109 49814374
Small for dates baby 11.31 10.96 93 784548 3412 49817071
Placental disorder 11.25 10.96 48 784593 1382 49819101
Rotator cuff syndrome 11.22 10.96 246 784395 11298 49809185
Hallucination, visual 11.22 10.96 185 784456 16397 49804086
Hemiparesis 11.22 10.96 398 784243 19650 49800833
Coronary artery insufficiency 11.19 10.96 10 784631 79 49820404
Cellulitis 11.18 10.96 1258 783383 69540 49750943
Peritoneal dialysis complication 11.18 10.96 42 784599 1139 49819344
Carpal tunnel syndrome 11.16 10.96 342 784299 16551 49803932
Depressed mood 11.13 10.96 423 784218 33600 49786883
Traumatic intracranial haemorrhage 11.12 10.96 21 784620 371 49820112
Arthritis 11.11 10.96 1521 783120 85200 49735283
Complication associated with device 11.11 10.96 160 784481 14495 49805988
Oesophageal haemorrhage 11.10 10.96 25 784616 503 49819980
Intracranial aneurysm 11.07 10.96 88 784553 3196 49817287
Lactose intolerance 11.04 10.96 73 784568 2497 49817986
Angiopathy 11.04 10.96 105 784536 4017 49816466
Carotid bruit 11.03 10.96 28 784613 610 49819873
Tibia fracture 11.02 10.96 112 784529 4363 49816120
International normalised ratio increased 11.01 10.96 794 783847 42358 49778125
Ventricular dysfunction 10.99 10.96 74 784567 2547 49817936
Cholelithiasis 10.97 10.96 706 783935 37267 49783216

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1432.37 12.38 4745 518067 105551 28946164
Coronary artery disease 1078.62 12.38 2401 520411 41789 29009926
Drug abuse 1057.03 12.38 97 522715 79786 28971929
Toxicity to various agents 889.84 12.38 1057 521755 172604 28879111
Off label use 791.44 12.38 2704 520108 298096 28753619
Completed suicide 734.36 12.38 338 522474 89908 28961807
Cardiac failure congestive 668.38 12.38 2904 519908 73677 28978038
Acute myocardial infarction 601.68 12.38 2055 520757 46383 29005332
Drug ineffective 558.86 12.38 3947 518865 359223 28692492
Cerebrovascular accident 421.62 12.38 2561 520251 74350 28977365
Febrile neutropenia 398.90 12.38 869 521943 111371 28940344
Gastrointestinal haemorrhage 397.79 12.38 2587 520225 76946 28974769
Product use in unapproved indication 368.93 12.38 604 522208 86271 28965444
Gastric haemorrhage 318.44 12.38 582 522230 8715 29043000
Angina unstable 317.77 12.38 636 522176 10229 29041486
Coronary arterial stent insertion 278.16 12.38 344 522468 3553 29048162
Angina pectoris 271.38 12.38 1093 521719 26757 29024958
Death 271.04 12.38 4338 518474 337746 28713969
Coronary artery bypass 269.73 12.38 372 522440 4313 29047402
Thrombosis in device 236.69 12.38 286 522526 2878 29048837
Chest pain 210.59 12.38 2958 519854 109015 28942700
Coronary artery occlusion 198.90 12.38 505 522307 9589 29042126
Pyrexia 176.63 12.38 3810 519002 283812 28767903
Intentional overdose 175.74 12.38 255 522557 38273 29013442
Drug reaction with eosinophilia and systemic symptoms 167.11 12.38 149 522663 27843 29023872
Drug dependence 156.38 12.38 88 522724 20893 29030822
Myocardial ischaemia 151.31 12.38 623 522189 15405 29036310
Neutropenia 146.60 12.38 1554 521258 130157 28921558
Transient ischaemic attack 144.28 12.38 801 522011 22469 29029246
Malignant neoplasm progression 144.09 12.38 743 522069 73116 28978599
Intentional product misuse 143.28 12.38 245 522567 34416 29017299
Suicide attempt 140.18 12.38 242 522570 33868 29017847
Overdose 138.79 12.38 834 521978 78985 28972730
Coronary artery stenosis 133.09 12.38 393 522419 8180 29043535
Drug resistance 130.57 12.38 113 522699 21427 29030288
Haemorrhage 127.60 12.38 1288 521524 43784 29007931
Haemoglobin decreased 120.87 12.38 2634 520178 105741 28945974
Milk-alkali syndrome 119.68 12.38 88 522724 434 29051281
Sopor 119.25 12.38 24 522788 10910 29040805
Coma 111.82 12.38 342 522470 39108 29012607
Melaena 110.50 12.38 935 521877 30241 29021474
Cytomegalovirus infection 110.49 12.38 149 522663 23066 29028649
Upper gastrointestinal haemorrhage 110.07 12.38 714 522098 21200 29030515
Dizziness 109.82 12.38 4244 518568 185440 28866275
Drug interaction 109.21 12.38 2656 520156 194729 28856986
Plasma cell myeloma 108.13 12.38 1067 521745 36048 29015667
Serotonin syndrome 107.20 12.38 91 522721 17421 29034294
Treatment failure 104.86 12.38 320 522492 36619 29015096
Hepatocellular injury 103.50 12.38 134 522678 21109 29030606
Disease progression 103.01 12.38 938 521874 80978 28970737
Gastric ulcer 100.18 12.38 503 522309 13558 29038157
Immune reconstitution inflammatory syndrome 94.23 12.38 13 522799 7789 29043926
Product use issue 90.18 12.38 536 522276 50908 29000807
Syncope 89.80 12.38 1975 520837 79396 28972319
Intentional self-injury 88.99 12.38 55 522757 12406 29039309
Atrial fibrillation 88.48 12.38 2470 520342 103176 28948539
Thrombosis 85.58 12.38 1149 521663 41896 29009819
Hospitalisation 85.54 12.38 470 522342 45518 29006197
Psychotic disorder 84.91 12.38 143 522669 20211 29031504
Intentional product use issue 83.12 12.38 427 522385 42071 29009644
Duodenal ulcer 82.45 12.38 353 522459 8885 29042830
Suicidal ideation 82.18 12.38 325 522487 34391 29017324
Post transplant lymphoproliferative disorder 80.35 12.38 4 522808 5489 29046226
Respiratory arrest 79.76 12.38 215 522597 25618 29026097
Neuroleptic malignant syndrome 79.56 12.38 101 522711 16047 29035668
Septic shock 79.22 12.38 715 522097 61845 28989870
Neurotoxicity 78.87 12.38 85 522727 14528 29037187
Vascular graft 78.57 12.38 109 522703 1271 29050444
Multiple organ dysfunction syndrome 78.34 12.38 725 522087 62391 28989324
Pathogen resistance 76.57 12.38 24 522788 8092 29043623
Poisoning 75.79 12.38 41 522771 9952 29041763
Haematocrit decreased 75.34 12.38 815 521997 28207 29023508
Venoocclusive liver disease 73.75 12.38 16 522796 6901 29044814
Somnolence 73.37 12.38 1193 521619 92762 28958953
Arteriosclerosis 72.44 12.38 366 522446 9890 29041825
Hepatic function abnormal 71.50 12.38 404 522408 38855 29012860
Faeces discoloured 71.37 12.38 442 522370 12909 29038806
Arteriosclerosis coronary artery 70.42 12.38 372 522440 10233 29041482
Respiratory depression 70.42 12.38 81 522731 13442 29038273
Lower gastrointestinal haemorrhage 70.36 12.38 310 522502 7903 29043812
Acute graft versus host disease 69.65 12.38 10 522802 5814 29045901
Coronary artery restenosis 69.40 12.38 88 522724 934 29050781
Diverticulum 69.40 12.38 258 522554 6074 29045641
Haematemesis 69.31 12.38 703 522109 23923 29027792
Coronary artery thrombosis 69.26 12.38 126 522686 1879 29049836
Interstitial lung disease 69.06 12.38 669 522143 57049 28994666
Haemorrhage intracranial 68.90 12.38 467 522345 14075 29037640
Vascular stent stenosis 67.28 12.38 87 522725 943 29050772
Cytokine release syndrome 66.79 12.38 80 522732 13039 29038676
Poisoning deliberate 65.90 12.38 11 522801 5720 29045995
Rash maculo-papular 65.02 12.38 216 522596 24073 29027642
Posterior reversible encephalopathy syndrome 64.96 12.38 39 522773 8937 29042778
Fall 64.93 12.38 3789 519023 173389 28878326
Vascular stent thrombosis 64.91 12.38 143 522669 2467 29049248
Ischaemic cardiomyopathy 64.55 12.38 233 522579 5405 29046310
Fatigue 64.52 12.38 6467 516345 310354 28741361
Aggression 64.04 12.38 367 522445 35174 29016541
Carotid artery stenosis 62.94 12.38 198 522614 4271 29047444
Substance abuse 62.39 12.38 21 522791 6766 29044949
Condition aggravated 62.27 12.38 2041 520771 144254 28907461
Cardiac disorder 60.37 12.38 960 521852 36303 29015412
Mitral valve incompetence 59.50 12.38 421 522391 12872 29038843
Sedation 58.26 12.38 139 522673 17266 29034449
Gastritis 58.25 12.38 564 522248 18953 29032762
Mucosal inflammation 58.14 12.38 324 522488 31271 29020444
Status epilepticus 58.02 12.38 63 522749 10731 29040984
Bronchopulmonary aspergillosis 57.96 12.38 80 522732 12264 29039451
Haemophagocytic lymphohistiocytosis 57.92 12.38 60 522752 10444 29041271
Graft versus host disease 57.75 12.38 51 522761 9577 29042138
Rheumatoid arthritis 57.75 12.38 843 521969 31309 29020406
Gastritis erosive 57.66 12.38 218 522594 5175 29046540
No adverse event 57.39 12.38 141 522671 17337 29034378
Seizure 57.30 12.38 1232 521580 91891 28959824
Vomiting 56.93 12.38 3120 519692 209140 28842575
Drug withdrawal syndrome 56.79 12.38 148 522664 17836 29033879
Drug ineffective for unapproved indication 56.44 12.38 103 522709 14111 29037604
Therapeutic product effect incomplete 56.17 12.38 435 522377 38870 29012845
Infective pulmonary exacerbation of cystic fibrosis 56.11 12.38 20 522792 6216 29045499
Leukopenia 55.14 12.38 667 522145 54536 28997179
Mucormycosis 54.85 12.38 12 522800 5146 29046569
Febrile bone marrow aplasia 54.53 12.38 31 522781 7320 29044395
Ascites 54.36 12.38 401 522411 36218 29015497
Akathisia 53.61 12.38 26 522786 6716 29044999
Acute graft versus host disease in skin 53.52 12.38 9 522803 4655 29047060
Sepsis 53.29 12.38 2023 520789 140659 28911056
Toxic epidermal necrolysis 53.14 12.38 155 522657 17998 29033717
Agitation 53.12 12.38 615 522197 50689 29001026
Haematotoxicity 53.01 12.38 26 522786 6673 29045042
Myelosuppression 52.77 12.38 84 522728 12143 29039572
Occult blood positive 52.45 12.38 165 522647 3559 29048156
Hyperlipidaemia 51.92 12.38 391 522421 12199 29039516
Bone marrow failure 51.32 12.38 280 522532 27169 29024546
Hepatic failure 50.73 12.38 337 522475 31175 29020540
Wrong technique in product usage process 50.15 12.38 337 522475 31091 29020624
Rectal haemorrhage 48.98 12.38 871 521941 33678 29018037
Acute coronary syndrome 48.72 12.38 379 522433 11946 29039769
Aspergillus infection 48.26 12.38 70 522742 10511 29041204
Suspected suicide 47.85 12.38 7 522805 4013 29047702
Cytomegalovirus viraemia 47.82 12.38 26 522786 6294 29045421
Peripheral vascular disorder 47.50 12.38 183 522629 4384 29047331
Neoplasm progression 47.45 12.38 169 522643 18443 29033272
Hyperbilirubinaemia 47.08 12.38 123 522689 14811 29036904
Accidental exposure to product 46.29 12.38 74 522738 10679 29041036
Adenovirus infection 45.98 12.38 11 522801 4436 29047279
Stomatitis 45.73 12.38 427 522385 36686 29015029
Aspirin-exacerbated respiratory disease 44.91 12.38 43 522769 323 29051392
International normalised ratio increased 44.86 12.38 1064 521748 43308 29008407
Chronic obstructive pulmonary disease 44.80 12.38 993 521819 39962 29011753
Gastrooesophageal reflux disease 44.64 12.38 794 522018 30702 29021013
Contusion 44.11 12.38 784 522028 30311 29021404
Chronic graft versus host disease 43.61 12.38 9 522803 4020 29047695
Agranulocytosis 42.86 12.38 199 522613 20141 29031574
Hepatitis B reactivation 42.45 12.38 4 522808 3225 29048490
Acute kidney injury 41.78 12.38 4080 518732 261187 28790528
Hyperthermia 41.44 12.38 64 522748 9366 29042349
Therapy partial responder 41.41 12.38 20 522792 5179 29046536
Dystonia 41.11 12.38 68 522744 9681 29042034
Subarachnoid haemorrhage 41.10 12.38 303 522509 9389 29042326
Altered state of consciousness 41.08 12.38 196 522616 19693 29032022
Thrombocytopenia 41.01 12.38 1956 520856 132867 28918848
Tricuspid valve incompetence 40.62 12.38 271 522541 8123 29043592
Graft versus host disease in gastrointestinal tract 40.38 12.38 5 522807 3253 29048462
Cerebral haemorrhage 39.94 12.38 779 522033 30647 29021068
Ventricular hypertrophy 39.65 12.38 165 522647 4099 29047616
Carotid artery occlusion 39.30 12.38 100 522712 1901 29049814
Respiratory failure 38.74 12.38 1366 521446 95765 28955950
Cardio-respiratory arrest 38.64 12.38 645 522167 49956 29001759
Drug use disorder 38.40 12.38 7 522805 3415 29048300
Withdrawal syndrome 38.22 12.38 86 522726 10906 29040809
Thrombotic microangiopathy 38.07 12.38 59 522753 8622 29043093
Haematuria 38.02 12.38 1036 521776 43103 29008612
Cystitis haemorrhagic 38.00 12.38 19 522793 4823 29046892
Pneumocystis jirovecii pneumonia 37.87 12.38 160 522652 16619 29035096
Cardiovascular disorder 37.70 12.38 279 522533 8656 29043059
Palmar-plantar erythrodysaesthesia syndrome 37.64 12.38 134 522678 14625 29037090
Epstein-Barr virus infection 37.54 12.38 37 522775 6592 29045123
Progressive multifocal leukoencephalopathy 37.53 12.38 60 522752 8659 29043056
Neutrophil count decreased 37.09 12.38 544 522268 43023 29008692
Tachycardia 37.05 12.38 985 521827 71425 28980290
Encephalopathy 37.04 12.38 360 522452 30683 29021032
Myalgia 36.27 12.38 1628 521184 72391 28979324
Ventricular dysfunction 35.90 12.38 135 522677 3196 29048519
Pneumonia aspiration 35.87 12.38 446 522366 36291 29015424
Vascular pseudoaneurysm 35.81 12.38 95 522717 1854 29049861
Lymphopenia 35.77 12.38 121 522691 13412 29038303
Full blood count decreased 35.62 12.38 436 522376 15556 29036159
Apparent death 35.59 12.38 9 522803 3495 29048220
Hyperammonaemia 35.18 12.38 29 522783 5634 29046081
Transaminases increased 35.16 12.38 245 522567 22417 29029298
Gastric ulcer haemorrhage 35.15 12.38 176 522636 4738 29046977
Carotid artery disease 35.06 12.38 58 522754 798 29050917
Subdural haematoma 35.06 12.38 483 522329 17710 29034005
Stent placement 34.98 12.38 160 522652 4146 29047569
Incorrect route of product administration 34.78 12.38 88 522724 10713 29041002
BK virus infection 34.70 12.38 20 522792 4687 29047028
Miosis 34.58 12.38 55 522757 7954 29043761
Hiatus hernia 34.51 12.38 221 522591 6531 29045184
Paradoxical drug reaction 34.48 12.38 4 522808 2737 29048978
Depressed level of consciousness 34.40 12.38 453 522359 36489 29015226
Hepatic encephalopathy 34.14 12.38 117 522695 12918 29038797
Virologic failure 33.79 12.38 5 522807 2842 29048873
Ventricular tachycardia 33.75 12.38 574 522238 22000 29029715
Irritability 33.63 12.38 241 522571 21911 29029804
Labelled drug-drug interaction medication error 33.20 12.38 345 522467 11814 29039901
Muscle spasms 32.89 12.38 1436 521376 63646 28988069
Multiple-drug resistance 32.63 12.38 14 522798 3886 29047829
Electrocardiogram QT prolonged 32.25 12.38 447 522365 35690 29016025
Pseudomonas infection 32.24 12.38 92 522720 10760 29040955
Tumour lysis syndrome 32.20 12.38 131 522681 13753 29037962
Polyomavirus-associated nephropathy 32.11 12.38 10 522802 3386 29048329
Accidental overdose 32.04 12.38 181 522631 17412 29034303
Cholestasis 31.97 12.38 263 522549 23199 29028516
Arterial occlusive disease 31.83 12.38 146 522666 3788 29047927
Delirium 31.80 12.38 497 522315 38900 29012815
Brain oedema 31.79 12.38 110 522702 12110 29039605
Dysmorphism 31.68 12.38 120 522692 2851 29048864
Mitochondrial toxicity 31.66 12.38 3 522809 2408 29049307
Abnormal behaviour 31.63 12.38 259 522553 22868 29028847
Cytomegalovirus chorioretinitis 31.59 12.38 9 522803 3229 29048486
Asthenia 31.47 12.38 4303 518509 210947 28840768
Multiple injuries 31.24 12.38 85 522727 1685 29050030
Venoocclusive disease 31.21 12.38 4 522808 2535 29049180
Alcohol abuse 31.11 12.38 19 522793 4314 29047401
Acute myeloid leukaemia 31.11 12.38 168 522644 16345 29035370
Dyspnoea 31.00 12.38 6381 516431 320351 28731364
Post procedural complication 30.89 12.38 300 522512 10089 29041626
Drug level increased 30.70 12.38 200 522612 18587 29033128
Cardiac murmur 30.51 12.38 211 522601 6402 29045313
Mania 29.94 12.38 68 522744 8595 29043120
Eosinophilia 29.93 12.38 249 522563 21912 29029803
Blood glucose increased 29.92 12.38 1302 521510 57682 28994033
Drug-induced liver injury 29.85 12.38 242 522570 21413 29030302
Diastolic dysfunction 29.85 12.38 172 522640 4892 29046823
Hepatitis B 29.63 12.38 32 522780 5465 29046250
Lactic acidosis 29.61 12.38 367 522445 29880 29021835
Lipodystrophy acquired 29.46 12.38 9 522803 3085 29048630
Respiratory distress 29.42 12.38 395 522417 31711 29020004
Non-cardiac chest pain 29.21 12.38 143 522669 3814 29047901
Sinus node dysfunction 29.05 12.38 137 522675 3597 29048118
Second primary malignancy 29.00 12.38 46 522766 6659 29045056
Obsessive-compulsive disorder 28.97 12.38 23 522789 4553 29047162
Lacunar infarction 28.54 12.38 112 522700 2707 29049008
Haematochezia 28.51 12.38 856 521956 36127 29015588
Osteonecrosis of jaw 28.40 12.38 173 522639 16337 29035378
Blood urea increased 28.37 12.38 674 522138 27438 29024277
Viral mutation identified 28.11 12.38 5 522807 2483 29049232
Left ventricular failure 28.06 12.38 159 522653 4494 29047221
Drug hypersensitivity 27.96 12.38 959 521853 67447 28984268
Hepatocellular carcinoma 27.94 12.38 51 522761 6987 29044728
Nephropathy toxic 27.86 12.38 97 522715 10659 29041056
Disinhibition 27.86 12.38 6 522806 2601 29049114
Back disorder 27.81 12.38 191 522621 5782 29045933
Tooth disorder 27.76 12.38 274 522538 9255 29042460
Aortic stenosis 27.52 12.38 139 522673 3755 29047960
Duodenitis 27.42 12.38 145 522667 3990 29047725
Ventricular extrasystoles 27.37 12.38 297 522515 10285 29041430
Haematoma 27.37 12.38 569 522243 22643 29029072
Osteoarthritis 27.31 12.38 461 522351 17642 29034073
Hypokalaemia 27.25 12.38 677 522135 49526 29002189
Hypertransaminasaemia 27.05 12.38 15 522797 3591 29048124
Retroperitoneal haemorrhage 26.98 12.38 102 522710 2421 29049294
Device use error 26.94 12.38 3 522809 2119 29049596
Dilatation atrial 26.82 12.38 83 522729 1774 29049941
Angiopathy 26.77 12.38 133 522679 3569 29048146
Large intestine polyp 26.75 12.38 202 522610 6307 29045408
General physical health deterioration 26.74 12.38 1516 521296 101341 28950374
Syringe issue 26.53 12.38 17 522795 3761 29047954
Peripheral arterial occlusive disease 26.47 12.38 167 522645 4909 29046806
Disseminated intravascular coagulation 26.31 12.38 226 522586 19754 29031961
Peptic ulcer 26.19 12.38 100 522712 2385 29049330
Unintentional medical device removal 26.13 12.38 5 522807 2356 29049359
Graft versus host disease in skin 25.42 12.38 14 522798 3365 29048350
Exposure to toxic agent 25.42 12.38 7 522805 2568 29049147
Gastrointestinal arteriovenous malformation 25.29 12.38 31 522781 317 29051398
Toxic skin eruption 25.27 12.38 88 522724 9669 29042046
Hallucination, auditory 25.20 12.38 86 522726 9507 29042208
Duodenal ulcer haemorrhage 25.02 12.38 150 522662 4329 29047386
Aplasia 25.00 12.38 21 522791 4042 29047673
Arterial restenosis 24.98 12.38 16 522796 60 29051655
Sudden cardiac death 24.91 12.38 118 522694 3104 29048611
Haemorrhoids 24.75 12.38 315 522497 11342 29040373
Bundle branch block left 24.72 12.38 169 522643 5108 29046607
Cytomegalovirus infection reactivation 23.81 12.38 15 522797 3349 29048366
Acute graft versus host disease in intestine 23.80 12.38 6 522806 2335 29049380
Chest discomfort 23.76 12.38 1017 521795 44966 29006749
Ecchymosis 23.66 12.38 191 522621 6089 29045626
Lymphocyte count decreased 23.61 12.38 222 522590 19049 29032666
Post procedural haemorrhage 23.60 12.38 219 522593 7272 29044443
Body height decreased 23.58 12.38 122 522690 3328 29048387
Eye haemorrhage 23.41 12.38 129 522683 3607 29048108
Psychomotor hyperactivity 23.40 12.38 71 522741 8142 29043573
Cerebrovascular disorder 23.22 12.38 76 522736 1675 29050040
Oesophageal ulcer 23.21 12.38 113 522699 3007 29048708
Renal impairment 23.14 12.38 1188 521624 80145 28971570
Intermittent claudication 22.98 12.38 84 522728 1961 29049754
Wrong patient received product 22.91 12.38 6 522806 2276 29049439
Pain in extremity 22.88 12.38 2258 520554 108175 28943540
Extrapyramidal disorder 22.80 12.38 106 522706 10725 29040990
Infusion related reaction 22.70 12.38 596 522216 43290 29008425
Carotid bruit 22.61 12.38 22 522790 169 29051546
Myoclonus 22.61 12.38 140 522672 13169 29038546
Myocarditis 22.61 12.38 108 522704 10848 29040867
Mydriasis 22.50 12.38 46 522766 6039 29045676
Diffuse large B-cell lymphoma recurrent 22.25 12.38 9 522803 2588 29049127
Dyspnoea exertional 22.10 12.38 821 521991 35669 29016046
Hepatitis C 21.99 12.38 82 522730 8828 29042887
Transplant rejection 21.95 12.38 86 522726 9126 29042589
Euphoric mood 21.93 12.38 32 522780 4793 29046922
Acute hepatic failure 21.75 12.38 123 522689 11829 29039886
Fungal infection 21.70 12.38 147 522665 13538 29038177
Percutaneous coronary intervention 21.68 12.38 23 522789 198 29051517
Acute generalised exanthematous pustulosis 21.68 12.38 41 522771 5542 29046173
Shunt stenosis 21.61 12.38 38 522774 551 29051164
Injection site pain 21.48 12.38 424 522388 32022 29019693
Hyperthermia malignant 21.48 12.38 3 522809 1781 29049934
Page kidney 21.47 12.38 13 522799 43 29051672
Electrocardiogram ST segment depression 21.46 12.38 86 522726 2099 29049616
Shunt occlusion 21.42 12.38 43 522769 693 29051022
Blood cholesterol increased 21.33 12.38 391 522421 15204 29036511
Traumatic intracranial haemorrhage 21.33 12.38 39 522773 584 29051131
Erosive duodenitis 21.33 12.38 61 522751 1246 29050469
Oedema peripheral 21.24 12.38 2116 520696 101441 28950274
JC virus infection 21.03 12.38 4 522808 1893 29049822
Small intestinal haemorrhage 21.01 12.38 79 522733 1870 29049845
Muscular weakness 20.96 12.38 1318 521494 60734 28990981
Lung disorder 20.95 12.38 394 522418 29968 29021747
Catatonia 20.93 12.38 29 522783 4439 29047276
Spinal disorder 20.81 12.38 124 522688 3571 29048144
Helicobacter gastritis 20.78 12.38 53 522759 1009 29050706
Acute respiratory distress syndrome 20.71 12.38 283 522529 22652 29029063
Drug screen positive 20.63 12.38 22 522790 3779 29047936
Hepatotoxicity 20.56 12.38 209 522603 17658 29034057
Electrocardiogram ST segment elevation 20.53 12.38 143 522669 4349 29047366
Restlessness 20.09 12.38 273 522539 21872 29029843
Rhabdomyolysis 20.07 12.38 1289 521523 59519 28992196
Hypercholesterolaemia 20.06 12.38 206 522606 7032 29044683
Polyneuropathy 20.04 12.38 129 522683 12023 29039692
Intraventricular haemorrhage 20.03 12.38 103 522709 2803 29048912
Gingival bleeding 20.00 12.38 188 522624 6265 29045450
Haemorrhagic stroke 19.88 12.38 174 522638 5682 29046033
Aortic aneurysm 19.68 12.38 182 522630 6038 29045677
Nausea 19.63 12.38 4674 518138 284581 28767134
Spinal osteoarthritis 19.62 12.38 185 522627 6171 29045544
Blood creatine phosphokinase MB increased 19.60 12.38 72 522740 1685 29050030
Speech disorder developmental 19.49 12.38 76 522736 1831 29049884
Swollen tongue 19.48 12.38 315 522497 11951 29039764
Enterocolitis 19.45 12.38 57 522755 6609 29045106
Pancytopenia 19.44 12.38 1238 521574 81930 28969785
Back pain 19.41 12.38 2079 520733 100205 28951510
Cardiomegaly 19.41 12.38 347 522465 13429 29038286
Metabolic acidosis 19.33 12.38 512 522300 37150 29014565
Angioedema 19.31 12.38 718 522094 31197 29020518
Device leakage 19.28 12.38 31 522781 4464 29047251
Device related infection 19.21 12.38 180 522632 15456 29036259
Alcohol interaction 19.20 12.38 12 522800 2691 29049024
Arthropathy 19.15 12.38 508 522304 21046 29030669
Sickle cell anaemia with crisis 19.07 12.38 94 522718 2514 29049201
Dermatitis acneiform 19.06 12.38 43 522769 5448 29046267
Hypertriglyceridaemia 18.97 12.38 68 522744 7407 29044308
Thrombotic thrombocytopenic purpura 18.97 12.38 109 522703 3097 29048618
Coronary artery insufficiency 18.90 12.38 14 522798 70 29051645
Atrial flutter 18.88 12.38 348 522464 13546 29038169
Spinal stenosis 18.84 12.38 137 522675 4226 29047489
Nocardiosis 18.69 12.38 18 522794 3242 29048473
Hyponatraemia 18.64 12.38 991 521821 66642 28985073
Aortic valve incompetence 18.63 12.38 152 522660 4861 29046854
Coagulation time abnormal 18.53 12.38 18 522794 138 29051577
Extraocular muscle disorder 18.36 12.38 20 522792 178 29051537
Peripheral artery aneurysm 18.36 12.38 28 522784 358 29051357
Cataract 18.35 12.38 522 522290 21856 29029859
Iron deficiency anaemia 18.30 12.38 240 522572 8702 29043013
Gout 18.16 12.38 409 522403 16502 29035213
Retroperitoneal haematoma 17.97 12.38 86 522726 2272 29049443
Basal ganglia infarction 17.95 12.38 18 522794 144 29051571
Bacteraemia 17.94 12.38 193 522619 16130 29035585
Epilepsy 17.90 12.38 224 522588 18208 29033507
International normalised ratio decreased 17.77 12.38 131 522681 4059 29047656
Benign prostatic hyperplasia 17.59 12.38 298 522514 11412 29040303
Blood loss anaemia 17.46 12.38 201 522611 7065 29044650
Mallory-Weiss syndrome 17.45 12.38 56 522756 1221 29050494
Coronary ostial stenosis 17.40 12.38 13 522799 66 29051649
Anaemia 17.36 12.38 3908 518904 197043 28854672
Proteinuria 17.31 12.38 187 522625 15617 29036098
Gastrointestinal ulcer 17.31 12.38 66 522746 1573 29050142
Hypoalbuminaemia 17.19 12.38 109 522703 10196 29041519
Skin toxicity 17.15 12.38 25 522787 3746 29047969
Cholelithiasis 17.15 12.38 442 522370 18230 29033485
Accidental death 17.10 12.38 8 522804 2110 29049605
Metastases to lung 17.06 12.38 76 522736 7779 29043936
Arteriovenous malformation 16.97 12.38 38 522774 663 29051052
Stevens-Johnson syndrome 16.97 12.38 198 522614 16299 29035416
Hypoaesthesia 16.85 12.38 1129 521683 52338 28999377
Epigastric discomfort 16.85 12.38 73 522739 1847 29049868
Dermatitis exfoliative generalised 16.83 12.38 16 522796 2900 29048815
Adrenal insufficiency 16.83 12.38 121 522691 10993 29040722
Aortic valve sclerosis 16.78 12.38 41 522771 759 29050956
Paranoia 16.72 12.38 104 522708 9773 29041942
Human herpesvirus 6 infection 16.72 12.38 6 522806 1857 29049858
Arthralgia 16.70 12.38 2760 520052 136857 28914858
Infection 16.67 12.38 1150 521662 75601 28976114
Basal cell carcinoma 16.63 12.38 404 522408 16506 29035209
Anaphylactic shock 16.61 12.38 153 522659 13183 29038532
Erythema 16.56 12.38 1132 521680 74474 28977241
Vascular graft occlusion 16.51 12.38 33 522779 530 29051185
Renal cyst 16.51 12.38 213 522599 7694 29044021
Ulcer haemorrhage 16.46 12.38 86 522726 2355 29049360
Middle ear effusion 16.43 12.38 33 522779 532 29051183
Prosthesis implantation 16.24 12.38 8 522804 15 29051700
Reye's syndrome 16.18 12.38 7 522805 8 29051707
Gallbladder disorder 16.17 12.38 163 522649 5537 29046178
Increased tendency to bruise 16.05 12.38 113 522699 3449 29048266
Multiple sclerosis relapse 16.02 12.38 127 522685 11292 29040423
Rotator cuff syndrome 16.01 12.38 146 522666 4824 29046891
Coronary angioplasty 16.01 12.38 26 522786 352 29051363
Generalised tonic-clonic seizure 15.93 12.38 240 522572 18899 29032816
Blood creatinine increased 15.90 12.38 1728 521084 83374 28968341
Subdural haemorrhage 15.87 12.38 95 522717 2740 29048975
Vitreous haemorrhage 15.76 12.38 74 522738 1939 29049776
Aortic valve stenosis 15.73 12.38 79 522733 2129 29049586
Puncture site haemorrhage 15.71 12.38 22 522790 259 29051456
Enterococcal infection 15.64 12.38 84 522728 8184 29043531
Psychotic symptom 15.64 12.38 3 522809 1411 29050304
Hungry bone syndrome 15.62 12.38 12 522800 64 29051651
Chromaturia 15.48 12.38 315 522497 12487 29039228
Vascular graft complication 15.47 12.38 14 522798 97 29051618
Fat embolism 15.42 12.38 18 522794 174 29051541
Heparin-induced thrombocytopenia 15.40 12.38 145 522667 4834 29046881
Blindness transient 15.34 12.38 71 522741 1849 29049866
Epistaxis 15.28 12.38 1086 521726 50618 29001097
Granulomatous pneumonitis 15.25 12.38 9 522803 28 29051687
Electrocardiogram Q wave abnormal 15.19 12.38 23 522789 292 29051423
Candida infection 15.17 12.38 184 522628 15041 29036674
Inappropriate schedule of product administration 15.16 12.38 637 522175 43835 29007880
Disturbance in attention 15.09 12.38 277 522535 21147 29030568
Cytopenia 15.09 12.38 107 522705 9752 29041963
Cardiac aneurysm 15.04 12.38 40 522772 782 29050933
Psychiatric decompensation 15.01 12.38 4 522808 1500 29050215
Bradypnoea 14.91 12.38 12 522800 2359 29049356
Low density lipoprotein increased 14.85 12.38 119 522693 3785 29047930
Psoriatic arthropathy 14.75 12.38 352 522460 14339 29037376
Accidental exposure to product by child 14.71 12.38 3 522809 1351 29050364
Colitis 14.70 12.38 430 522382 30818 29020897
Ejection fraction decreased 14.60 12.38 378 522434 15600 29036115
Appendicitis 14.57 12.38 93 522719 8686 29043029
Lactose intolerance 14.55 12.38 50 522762 1131 29050584
Pericardial disease 14.48 12.38 25 522787 357 29051358
Nasopharyngitis 14.47 12.38 1234 521578 58431 28993284
Skin cancer 14.41 12.38 220 522592 8248 29043467
Renal tubular disorder 14.37 12.38 35 522777 4317 29047398
Vascular calcification 14.34 12.38 38 522774 741 29050974
Product substitution issue 14.30 12.38 99 522713 9073 29042642
Acute lymphocytic leukaemia recurrent 14.30 12.38 14 522798 2502 29049213
Drug eruption 14.25 12.38 209 522603 16532 29035183
Ulnar nerve injury 14.25 12.38 7 522805 13 29051702
Haemorrhage urinary tract 14.25 12.38 61 522751 1535 29050180
Intervertebral disc degeneration 14.20 12.38 149 522663 5115 29046600
Muscle haemorrhage 14.19 12.38 105 522707 3257 29048458
Device issue 14.19 12.38 80 522732 7700 29044015
Systemic candida 14.10 12.38 17 522795 2763 29048952
Foetal anticonvulsant syndrome 14.09 12.38 49 522763 1115 29050600
Vertebral artery stenosis 14.07 12.38 15 522797 130 29051585
Mitral valve calcification 14.05 12.38 30 522782 506 29051209
Diverticulum intestinal 14.03 12.38 103 522709 3187 29048528
Colonic haematoma 14.00 12.38 9 522803 34 29051681
Helicobacter test positive 13.97 12.38 34 522778 628 29051087
Prescription drug used without a prescription 13.94 12.38 3 522809 1301 29050414
Vascular procedure complication 13.93 12.38 7 522805 14 29051701
Subcapsular renal haematoma 13.92 12.38 25 522787 369 29051346
Occult blood 13.91 12.38 31 522781 539 29051176
Venous pressure jugular increased 13.87 12.38 36 522776 693 29051022
Aplastic anaemia 13.82 12.38 77 522735 7433 29044282
Medication error 13.79 12.38 278 522534 20933 29030782
Myocardial rupture 13.76 12.38 16 522796 154 29051561
Retinal artery embolism 13.76 12.38 8 522804 24 29051691
Urticaria 13.76 12.38 808 522004 53852 28997863
Nocturia 13.75 12.38 216 522596 8146 29043569
Deep vein thrombosis 13.74 12.38 1186 521626 56213 28995502
Antipsychotic drug level below therapeutic 13.70 12.38 9 522803 1965 29049750
Cerebral toxoplasmosis 13.70 12.38 4 522808 1412 29050303
Complications of transplanted kidney 13.70 12.38 31 522781 3923 29047792
Bundle branch block right 13.63 12.38 180 522632 6537 29045178
Skin flap necrosis 13.62 12.38 7 522805 15 29051700
Osteonecrosis 13.62 12.38 163 522649 13356 29038359
Aortic arteriosclerosis 13.59 12.38 116 522696 3760 29047955
Mediastinal haematoma 13.54 12.38 13 522799 98 29051617
Cardiac stress test abnormal 13.53 12.38 23 522789 324 29051391
Platelet aggregation increased 13.53 12.38 8 522804 25 29051690
Chronic kidney disease 13.51 12.38 780 522032 35636 29016079
Leukoencephalopathy 13.49 12.38 29 522783 3738 29047977
Thrombotic stroke 13.49 12.38 20 522792 249 29051466
Multiple allergies 13.45 12.38 73 522739 2029 29049686
Arterial haemorrhage 13.40 12.38 36 522776 708 29051007
Red blood cell count decreased 13.39 12.38 567 522245 25035 29026680
Silent myocardial infarction 13.39 12.38 22 522790 301 29051414
Viral load increased 13.35 12.38 10 522802 2039 29049676
Agonal rhythm 13.35 12.38 10 522802 51 29051664
Neonatal respiratory distress syndrome 13.35 12.38 114 522698 3696 29048019
Hepatitis 13.33 12.38 273 522539 20510 29031205
Small intestine polyp 13.33 12.38 7 522805 16 29051699
Coronary artery embolism 13.32 12.38 15 522797 139 29051576
Psoriasis 13.28 12.38 697 522115 31530 29020185
Catheterisation cardiac 13.26 12.38 74 522738 2079 29049636
Persecutory delusion 13.26 12.38 11 522801 2130 29049585
Shunt thrombosis 13.22 12.38 11 522801 67 29051648
Ischaemia 13.20 12.38 123 522689 4089 29047626
Dilatation ventricular 13.18 12.38 81 522731 2359 29049356
Ventricular hypokinesia 13.17 12.38 131 522681 4434 29047281
Renal haemorrhage 13.16 12.38 51 522761 1225 29050490
Erosive oesophagitis 13.16 12.38 54 522758 1333 29050382
Intervertebral disc protrusion 13.15 12.38 221 522591 8449 29043266
Depression 13.14 12.38 1311 521501 83836 28967879
High density lipoprotein decreased 13.13 12.38 94 522718 2885 29048830
Arterial stenosis 13.12 12.38 47 522765 1086 29050629
Incision site haemorrhage 13.09 12.38 28 522784 473 29051242
Asphyxia 13.06 12.38 49 522763 5266 29046449
Mitral valve disease 13.01 12.38 49 522763 1161 29050554
Abnormal clotting factor 12.98 12.38 6 522806 9 29051706
Pneumonia cytomegaloviral 12.98 12.38 17 522795 2665 29049050
Naevus flammeus 12.93 12.38 15 522797 144 29051571
Hypogammaglobulinaemia 12.92 12.38 57 522755 5850 29045865
Intracardiac thrombus 12.91 12.38 77 522735 2218 29049497
Diffuse large B-cell lymphoma 12.87 12.38 62 522750 6214 29045501
Brain stem stroke 12.85 12.38 15 522797 145 29051570
Troponin increased 12.83 12.38 231 522581 8952 29042763
Post procedural haematoma 12.81 12.38 55 522757 1386 29050329
Cerebral artery occlusion 12.80 12.38 34 522778 664 29051051
Stenosis 12.76 12.38 44 522768 997 29050718
Vertebral artery occlusion 12.67 12.38 16 522796 169 29051546
Cardiac ventricular thrombosis 12.67 12.38 41 522771 898 29050817
Coronary artery aneurysm 12.63 12.38 11 522801 72 29051643
Angioplasty 12.62 12.38 41 522771 900 29050815
Blood homocysteine increased 12.61 12.38 18 522794 216 29051499
Hypercalcaemia 12.60 12.38 305 522507 12454 29039261
Barrett's oesophagus 12.59 12.38 26 522786 428 29051287
Spinal epidural haematoma 12.56 12.38 19 522793 241 29051474
Salivary hypersecretion 12.55 12.38 78 522734 7331 29044384
Liver abscess 12.54 12.38 25 522787 3313 29048402
Skin discolouration 12.51 12.38 359 522453 15050 29036665
Hypoglycaemia neonatal 12.51 12.38 62 522750 1662 29050053
Laryngeal pain 12.50 12.38 84 522728 2524 29049191
Terminal state 12.42 12.38 27 522785 3467 29048248
Cardiac tamponade 12.41 12.38 131 522681 4504 29047211
Injection site reaction 12.41 12.38 132 522680 11056 29040659

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2284.80 11.27 6699 996025 159122 63336886
Completed suicide 1661.93 11.27 704 1002020 223710 63272298
Coronary artery disease 1558.18 11.27 3113 999611 57320 63438688
Drug abuse 1473.31 11.27 167 1002557 132207 63363801
Toxicity to various agents 1299.25 11.27 2289 1000435 361224 63134784
Cardiac failure congestive 1139.23 11.27 4530 998194 126050 63369958
Acute myocardial infarction 1043.57 11.27 2904 999820 66814 63429194
Cerebrovascular accident 928.27 11.27 4418 998306 133165 63362843
Off label use 838.58 11.27 6081 996643 626725 62869283
Gastrointestinal haemorrhage 628.83 11.27 3861 998863 128451 63367557
Febrile neutropenia 577.65 11.27 1288 1001436 186369 63309639
Angina unstable 479.18 11.27 862 1001862 14605 63481403
Coronary arterial stent insertion 452.70 11.27 499 1002225 5193 63490815
Drug ineffective 436.25 11.27 9854 992870 830393 62665615
Product use in unapproved indication 435.47 11.27 1354 1001370 175264 63320744
Coronary artery bypass 401.86 11.27 474 1002250 5341 63490667
Intentional overdose 328.05 11.27 558 1002166 89386 63406622
Transient ischaemic attack 319.81 11.27 1449 1001275 42733 63453275
Angina pectoris 304.59 11.27 1449 1001275 43632 63452376
Milk-alkali syndrome 303.72 11.27 204 1002520 989 63495019
Gastric haemorrhage 303.35 11.27 657 1002067 12824 63483184
Death 293.89 11.27 5511 997213 477194 63018814
Suicide attempt 264.96 11.27 434 1002290 70573 63425435
Thrombosis in device 259.57 11.27 356 1002368 4715 63491293
Coronary artery occlusion 257.34 11.27 627 1002097 13264 63482744
Drug reaction with eosinophilia and systemic symptoms 254.47 11.27 280 1002444 53937 63442071
Malignant neoplasm progression 253.52 11.27 901 1001823 111970 63384038
Chest pain 241.82 11.27 5076 997648 230904 63265104
Sopor 237.58 11.27 82 1002642 29579 63466429
Overdose 236.77 11.27 1480 1001244 158086 63337922
Haemoglobin decreased 234.62 11.27 4299 998425 190764 63305244
Neutropenia 216.31 11.27 2532 1000192 237092 63258916
Myocardial ischaemia 214.90 11.27 822 1001902 22429 63473579
Device expulsion 202.30 11.27 41 1002683 21095 63474913
Pyrexia 197.90 11.27 6905 995819 551739 62944269
Drug dependence 197.45 11.27 138 1002586 33174 63462834
Intentional product misuse 193.45 11.27 533 1002191 71762 63424246
Cytomegalovirus infection 190.65 11.27 178 1002546 37021 63458987
Coronary artery stenosis 187.75 11.27 488 1002236 10760 63485248
Drug resistance 183.42 11.27 165 1002559 34937 63461071
Intentional self-injury 180.67 11.27 114 1002610 28930 63467078
Respiratory arrest 175.99 11.27 348 1002376 52637 63443371
Upper gastrointestinal haemorrhage 167.86 11.27 1029 1001695 34191 63461817
Melaena 154.71 11.27 1389 1001335 52159 63443849
Gastric ulcer 150.24 11.27 893 1001831 29341 63466667
Hepatocellular injury 145.21 11.27 303 1002421 44932 63451076
Poisoning 144.39 11.27 80 1002644 21799 63474209
Coma 137.05 11.27 799 1001925 86816 63409192
Aspirin-exacerbated respiratory disease 136.99 11.27 126 1002598 1034 63494974
Serotonin syndrome 136.58 11.27 251 1002473 39031 63456977
Somnolence 136.23 11.27 2285 1000439 201360 63294648
Atrial fibrillation 135.64 11.27 3552 999172 167537 63328471
Arteriosclerosis coronary artery 133.77 11.27 537 1002187 14992 63481016
Poisoning deliberate 133.27 11.27 24 1002700 13434 63482574
Respiratory depression 132.60 11.27 102 1002622 23341 63472667
Fall 131.51 11.27 7824 994900 409002 63087006
Plasma cell myeloma 130.47 11.27 1190 1001534 44885 63451123
Duodenal ulcer 129.86 11.27 506 1002218 13929 63482079
Carotid artery stenosis 127.92 11.27 340 1002384 7601 63488407
Disease progression 125.82 11.27 1502 1001222 140178 63355830
Drug hypersensitivity 125.54 11.27 2778 999946 235037 63260971
Rheumatoid arthritis 121.41 11.27 3380 999344 160914 63335094
Neuroleptic malignant syndrome 116.28 11.27 130 1002594 24866 63471142
Post transplant lymphoproliferative disorder 111.41 11.27 10 1002714 9534 63486474
Arthropathy 110.99 11.27 2562 1000162 118405 63377603
Arteriosclerosis 110.63 11.27 515 1002209 15362 63480646
Neoplasm progression 110.33 11.27 301 1002423 40663 63455345
Vascular stent thrombosis 110.01 11.27 192 1002532 3172 63492836
Suspected suicide 109.89 11.27 6 1002718 8648 63487360
Haemorrhage 109.75 11.27 1789 1000935 77562 63418446
Cardio-respiratory arrest 108.63 11.27 991 1001733 97402 63398606
Haematocrit decreased 107.78 11.27 1312 1001412 53343 63442665
Thrombosis 106.94 11.27 1617 1001107 69025 63426983
Vascular graft 105.09 11.27 137 1002587 1722 63494286
Coronary artery thrombosis 104.76 11.27 172 1002552 2697 63493311
Gastritis erosive 103.73 11.27 357 1002367 9238 63486770
Venoocclusive liver disease 103.30 11.27 16 1002708 9999 63486009
Mitral valve incompetence 100.36 11.27 711 1002013 24827 63471181
Sedation 99.85 11.27 321 1002403 41141 63454867
Haematotoxicity 99.30 11.27 38 1002686 12858 63483150
Faeces discoloured 99.18 11.27 713 1002011 25016 63470992
Posterior reversible encephalopathy syndrome 97.56 11.27 128 1002596 22818 63473190
Immune reconstitution inflammatory syndrome 95.60 11.27 37 1002687 12433 63483575
Suicidal ideation 95.13 11.27 624 1002100 65918 63430090
Interstitial lung disease 94.24 11.27 1017 1001707 96715 63399293
Pemphigus 92.86 11.27 1392 1001332 59309 63436699
Acute graft versus host disease 92.60 11.27 15 1002709 9069 63486939
Febrile bone marrow aplasia 92.08 11.27 30 1002694 11225 63484783
Diverticulum 91.88 11.27 428 1002296 12770 63483238
Pathogen resistance 91.65 11.27 40 1002684 12503 63483505
Coronary artery restenosis 91.41 11.27 107 1002617 1195 63494813
Hepatic function abnormal 90.99 11.27 605 1002119 63708 63432300
Vascular stent stenosis 90.95 11.27 107 1002617 1202 63494806
Ischaemic cardiomyopathy 89.86 11.27 272 1002452 6566 63489442
Bronchopulmonary aspergillosis 89.06 11.27 99 1002625 18986 63477022
Wrong technique in product usage process 88.55 11.27 618 1002106 64356 63431652
Hepatic failure 87.77 11.27 503 1002221 54891 63441117
Multiple organ dysfunction syndrome 87.40 11.27 1082 1001642 100331 63395677
Haemophagocytic lymphohistiocytosis 87.04 11.27 87 1002637 17522 63478486
Haemorrhage intracranial 86.43 11.27 652 1002072 23232 63472776
Cytokine release syndrome 85.71 11.27 119 1002605 20710 63475298
Neurotoxicity 85.09 11.27 187 1002537 27217 63468791
Haematemesis 84.89 11.27 1110 1001614 45889 63450119
Myelosuppression 83.97 11.27 151 1002573 23679 63472329
Drug interaction 83.54 11.27 4690 998034 357393 63138615
Drug ineffective for unapproved indication 82.91 11.27 230 1002494 30903 63465105
Leukopenia 81.76 11.27 1095 1001629 100147 63395861
Graft versus host disease 80.83 11.27 58 1002666 13755 63482253
Lower gastrointestinal haemorrhage 80.70 11.27 429 1002295 13510 63482498
Acute graft versus host disease in skin 80.52 11.27 7 1002717 6848 63489160
Systemic lupus erythematosus 80.14 11.27 1672 1001052 75940 63420068
Ascites 79.53 11.27 600 1002124 61401 63434607
Bone marrow failure 79.48 11.27 429 1002295 47523 63448485
Rectal haemorrhage 79.36 11.27 1377 1001347 60440 63435568
Cholestasis 77.99 11.27 395 1002329 44477 63451531
Cardiac disorder 77.02 11.27 1258 1001466 54558 63441450
Accidental exposure to product 76.94 11.27 186 1002538 26178 63469830
Gastritis 76.34 11.27 1005 1001719 41613 63454395
Glossodynia 75.61 11.27 1420 1001304 63276 63432732
Ventricular hypertrophy 75.36 11.27 248 1002476 6268 63489740
Aspergillus infection 74.22 11.27 87 1002637 16292 63479716
Gastric ulcer haemorrhage 73.70 11.27 286 1002438 7857 63488151
Encephalopathy 73.66 11.27 573 1002151 58246 63437762
Mucormycosis 72.89 11.27 13 1002711 7328 63488680
Acute coronary syndrome 72.63 11.27 532 1002192 18778 63477230
Infective pulmonary exacerbation of cystic fibrosis 72.41 11.27 47 1002677 11749 63484259
Acute myeloid leukaemia 72.31 11.27 204 1002520 27259 63468749
Status epilepticus 72.17 11.27 142 1002582 21521 63474487
Hyperlipidaemia 72.09 11.27 607 1002117 22369 63473639
Hand deformity 72.07 11.27 1374 1001350 61397 63434611
Lacunar infarction 71.71 11.27 219 1002505 5313 63490695
Drug withdrawal syndrome 71.41 11.27 248 1002476 31043 63464965
Depressed level of consciousness 71.24 11.27 866 1001858 80570 63415438
Unintentional medical device removal 71.21 11.27 10 1002714 6724 63489284
Paradoxical drug reaction 69.88 11.27 7 1002717 6113 63489895
Adenovirus infection 69.58 11.27 14 1002710 7241 63488767
Palmar-plantar erythrodysaesthesia syndrome 69.47 11.27 223 1002501 28596 63467412
Neutrophil count decreased 69.03 11.27 817 1001907 76379 63419629
Drug use disorder 68.93 11.27 7 1002717 6047 63489961
Cerebral haemorrhage 68.84 11.27 1147 1001577 49943 63446065
Abdominal discomfort 68.49 11.27 3479 999245 178843 63317165
Graft versus host disease in gastrointestinal tract 67.95 11.27 5 1002719 5607 63490401
Electrocardiogram QT prolonged 67.94 11.27 849 1001875 78599 63417409
Syncope 67.69 11.27 3048 999676 154587 63341421
Withdrawal syndrome 67.56 11.27 167 1002557 23325 63472683
No adverse event 67.47 11.27 223 1002501 28338 63467670
Rash maculo-papular 67.21 11.27 441 1002283 46585 63449423
International normalised ratio increased 67.20 11.27 1659 1001065 77508 63418500
Mucosal inflammation 66.62 11.27 636 1002088 61948 63434060
Akathisia 66.48 11.27 49 1002675 11461 63484547
Toxic skin eruption 66.34 11.27 124 1002600 19160 63476848
Contusion 66.16 11.27 2277 1000447 111688 63384320
Substance abuse 65.76 11.27 31 1002693 9261 63486747
Cytomegalovirus viraemia 65.31 11.27 44 1002680 10784 63485224
Dizziness 65.15 11.27 7639 995085 422524 63073484
Septic shock 65.02 11.27 1200 1001524 104237 63391771
Epstein-Barr virus infection 64.88 11.27 59 1002665 12429 63483579
Tachycardia 64.04 11.27 1802 1000922 147777 63348231
Miosis 63.92 11.27 67 1002657 13199 63482809
Agranulocytosis 63.92 11.27 341 1002383 37888 63458120
Rhabdomyolysis 63.26 11.27 1871 1000853 89855 63406153
Wound 63.24 11.27 1597 1001127 74880 63421128
Device use error 63.09 11.27 12 1002712 6459 63489549
Altered state of consciousness 62.86 11.27 339 1002385 37563 63458445
Lymphocyte count decreased 62.12 11.27 374 1002350 40325 63455683
Labelled drug-drug interaction medication error 62.04 11.27 569 1002155 21493 63474515
Occult blood positive 62.03 11.27 227 1002497 6060 63489948
Dystonia 61.69 11.27 125 1002599 18740 63477268
Vomiting 61.26 11.27 7568 995156 543549 62952459
Exposure to toxic agent 60.95 11.27 11 1002713 6148 63489860
Hospitalisation 60.86 11.27 813 1001911 74394 63421614
Chronic obstructive pulmonary disease 60.04 11.27 1488 1001236 69560 63426448
Thrombocytopenia 59.89 11.27 2855 999869 220946 63275062
Retroperitoneal haemorrhage 59.67 11.27 189 1002535 4679 63491329
Mydriasis 59.55 11.27 91 1002633 15221 63480787
Pericarditis 59.16 11.27 1330 1001394 61186 63434822
Chronic graft versus host disease 58.37 11.27 13 1002711 6263 63489745
Thrombotic microangiopathy 58.27 11.27 106 1002618 16549 63479459
Urticaria 58.26 11.27 1794 1000930 145523 63350485
Maternal exposure during pregnancy 57.74 11.27 1924 1000800 93960 63402048
Exposure via ingestion 57.59 11.27 5 1002719 4897 63491111
Hepatitis B reactivation 57.40 11.27 5 1002719 4884 63491124
Cardiovascular disorder 57.16 11.27 433 1002291 15448 63480560
Hyperthermia 57.10 11.27 96 1002628 15454 63480554
Incorrect route of product administration 57.06 11.27 179 1002545 23119 63472889
Second primary malignancy 56.47 11.27 65 1002659 12272 63483736
Agitation 56.29 11.27 1000 1001724 87367 63408641
Aplasia 56.07 11.27 19 1002705 6934 63489074
Therapeutic product effect incomplete 55.62 11.27 1205 1001519 102277 63393731
Full blood count decreased 55.42 11.27 566 1002158 22016 63473992
Angioedema 55.33 11.27 1305 1001419 60516 63435492
Multiple injuries 54.92 11.27 143 1002581 3156 63492852
Subdural haematoma 54.24 11.27 671 1002053 27383 63468625
Seizure 54.03 11.27 2084 1000640 164808 63331200
Eosinophilia 53.94 11.27 358 1002366 37718 63458290
Hiatus hernia 53.75 11.27 510 1002214 19447 63476561
Device difficult to use 52.46 11.27 45 1002679 9753 63486255
Haematuria 51.85 11.27 1269 1001455 59202 63436806
Multiple sclerosis relapse 51.84 11.27 400 1002324 40735 63455273
Cystitis haemorrhagic 51.20 11.27 30 1002694 7926 63488082
Anaphylactic shock 50.99 11.27 270 1002454 30058 63465950
Peripheral vascular disorder 50.94 11.27 236 1002488 7025 63488983
Hypertransaminasaemia 50.87 11.27 24 1002700 7167 63488841
BK virus infection 50.52 11.27 26 1002698 7386 63488622
Irritability 50.31 11.27 349 1002375 36397 63459611
Helicobacter infection 49.76 11.27 856 1001868 37506 63458502
Sickle cell anaemia with crisis 49.67 11.27 189 1002535 5143 63490865
Disseminated intravascular coagulation 49.50 11.27 297 1002427 32051 63463957
Transplant rejection 49.03 11.27 125 1002599 17276 63478732
Brain oedema 49.01 11.27 177 1002547 21898 63474110
Exposure during pregnancy 48.92 11.27 1567 1001157 76108 63419900
Ventricular dysfunction 48.43 11.27 186 1002538 5084 63490924
Stent placement 48.26 11.27 193 1002531 5378 63490630
Tricuspid valve incompetence 48.05 11.27 439 1002285 16564 63479444
Tumour lysis syndrome 47.86 11.27 149 1002575 19291 63476717
Hyperbilirubinaemia 47.75 11.27 169 1002555 21036 63474972
Vascular pseudoaneurysm 47.56 11.27 131 1002593 2993 63493015
Mania 47.44 11.27 115 1002609 16171 63479837
Multiple-drug resistance 47.09 11.27 21 1002703 6481 63489527
Venoocclusive disease 46.99 11.27 4 1002720 3981 63492027
Therapy partial responder 46.90 11.27 54 1002670 10194 63485814
Femur fracture 46.22 11.27 767 1001957 33368 63462640
Osteonecrosis of jaw 46.18 11.27 396 1002328 39429 63456579
Metastases to liver 46.15 11.27 203 1002521 23738 63472270
Blood urea increased 45.83 11.27 952 1001772 43201 63452807
Anti-cyclic citrullinated peptide antibody positive 45.83 11.27 1051 1001673 48511 63447497
Carotid artery occlusion 45.66 11.27 152 1002572 3865 63492143
Pseudomonas infection 45.50 11.27 135 1002589 17748 63478260
Aggression 45.39 11.27 479 1002245 45753 63450255
Osteoarthritis 45.05 11.27 1297 1001427 62039 63433969
Haematoma 45.04 11.27 988 1001736 45262 63450746
Duodenitis 45.02 11.27 216 1002508 6525 63489483
Device issue 44.90 11.27 190 1002534 22458 63473550
Shunt stenosis 44.53 11.27 68 1002656 999 63495009
Pain in extremity 44.31 11.27 5371 997353 297714 63198294
Sepsis 43.90 11.27 3036 999688 227305 63268703
Disturbance in attention 43.89 11.27 417 1002307 40657 63455351
Abnormal behaviour 43.29 11.27 325 1002399 33297 63462711
Arthralgia 42.91 11.27 7655 995069 434605 63061403
Fatigue 42.86 11.27 12647 990077 736083 62759925
Pneumocystis jirovecii pneumonia 42.67 11.27 253 1002471 27381 63468627
Haemorrhoids 42.57 11.27 565 1002159 23436 63472572
Peripheral arterial occlusive disease 42.49 11.27 218 1002506 6769 63489239
Accidental overdose 42.43 11.27 326 1002398 33231 63462777
Subarachnoid haemorrhage 42.36 11.27 456 1002268 17982 63478026
Joint swelling 42.21 11.27 3893 998831 211489 63284519
Polyomavirus-associated nephropathy 41.84 11.27 12 1002712 4876 63491132
Spinal osteoarthritis 41.40 11.27 372 1002352 13969 63482039
Angiopathy 41.31 11.27 200 1002524 6065 63489943
Lymphopenia 41.17 11.27 232 1002492 25425 63470583
Graft versus host disease in skin 40.76 11.27 16 1002708 5331 63490677
Nausea 40.67 11.27 11239 991485 774561 62721447
Dilatation atrial 40.52 11.27 132 1002592 3318 63492690
Erythema 40.37 11.27 2438 1000286 184632 63311376
Duodenal ulcer haemorrhage 40.33 11.27 200 1002524 6125 63489883
Haematochezia 40.25 11.27 1333 1001391 65040 63430968
Gastrooesophageal reflux disease 40.24 11.27 1628 1001096 81515 63414493
Cerebrovascular disorder 39.95 11.27 133 1002591 3382 63492626
Post procedural complication 39.69 11.27 507 1002217 20846 63475162
Acute generalised exanthematous pustulosis 39.60 11.27 101 1002623 13957 63482051
Acute hepatic failure 39.30 11.27 241 1002483 25871 63470137
Aortic valve stenosis 39.14 11.27 158 1002566 4422 63491586
Psychomotor hyperactivity 39.05 11.27 106 1002618 14345 63481663
Myoclonus 38.76 11.27 230 1002494 24888 63471120
Hyperprolactinaemia 38.66 11.27 8 1002716 4057 63491951
Cytomegalovirus chorioretinitis 38.62 11.27 14 1002710 4898 63491110
Bradyphrenia 38.44 11.27 54 1002670 9352 63486656
Headache 38.22 11.27 7454 995270 522013 62973995
Complication of device insertion 38.21 11.27 15 1002709 4997 63491011
Respiratory failure 37.96 11.27 2083 1000641 159100 63336908
Cardiac murmur 37.62 11.27 308 1002416 11255 63484753
Aortic stenosis 37.60 11.27 197 1002527 6168 63489840
Restlessness 37.54 11.27 416 1002308 39369 63456639
Carotid artery disease 37.29 11.27 95 1002629 2068 63493940
Catatonia 37.26 11.27 38 1002686 7582 63488426
Hypertension 37.04 11.27 4588 998136 254673 63241335
Transaminases increased 36.83 11.27 480 1002244 44114 63451894
Acute graft versus host disease in intestine 36.70 11.27 6 1002718 3603 63492405
Polyneuropathy 36.37 11.27 172 1002552 19722 63476286
Ventricular tachycardia 36.28 11.27 741 1001983 33524 63462484
Non-cardiac chest pain 36.07 11.27 245 1002479 8435 63487573
Flushing 35.84 11.27 939 1001785 77709 63418299
Spinal stenosis 35.55 11.27 352 1002372 13579 63482429
Large intestine polyp 35.44 11.27 289 1002435 10548 63485460
Sinus node dysfunction 35.42 11.27 204 1002520 6624 63489384
Intentional product use issue 35.36 11.27 1171 1001553 94193 63401815
Synovitis 35.19 11.27 1881 1000843 97209 63398799
Shunt occlusion 35.00 11.27 66 1002658 1161 63494847
Epilepsy 34.73 11.27 343 1002381 33188 63462820
Transplant dysfunction 34.48 11.27 32 1002692 6676 63489332
Retroperitoneal haematoma 34.45 11.27 155 1002569 4556 63491452
Respiratory disorder 34.30 11.27 377 1002347 35734 63460274
Treatment failure 34.10 11.27 1476 1001248 115340 63380668
Hyperammonaemia 33.79 11.27 64 1002660 9840 63486168
Intraventricular haemorrhage 33.70 11.27 141 1002583 4012 63491996
Uterine perforation 33.33 11.27 25 1002699 5795 63490213
Psychotic disorder 33.24 11.27 360 1002364 34218 63461790
Viral mutation identified 33.06 11.27 6 1002718 3340 63492668
Hallucination, auditory 33.03 11.27 143 1002581 16796 63479212
Haemorrhagic stroke 32.88 11.27 266 1002458 9685 63486323
Blood loss anaemia 32.58 11.27 345 1002379 13547 63482461
General physical health deterioration 32.38 11.27 2736 999988 201689 63294319
Human herpesvirus 6 infection 32.21 11.27 16 1002708 4638 63491370
Metastases to bone 32.13 11.27 186 1002538 20249 63475759
Device dislocation 32.11 11.27 195 1002529 20983 63475025
Dermatitis acneiform 32.05 11.27 51 1002673 8392 63487616
Anaphylactic reaction 32.03 11.27 817 1001907 67847 63428161
Aortic valve incompetence 31.97 11.27 230 1002494 8071 63487937
Duodenal ulcer perforation 31.93 11.27 734 1001990 33891 63462117
Oedema peripheral 31.89 11.27 3736 998988 206581 63289427
Hypercalcaemia 31.83 11.27 675 1002049 30741 63465267
Blood prolactin abnormal 31.52 11.27 3 1002721 2729 63493279
Temperature regulation disorder 31.45 11.27 13 1002711 4198 63491810
Behaviour disorder 31.40 11.27 15 1002709 4447 63491561
Migraine 31.36 11.27 738 1001986 61939 63434069
Cytomegalovirus infection reactivation 31.35 11.27 26 1002698 5730 63490278
Abortion incomplete 31.32 11.27 5 1002719 3056 63492952
Swollen tongue 31.32 11.27 738 1001986 34216 63461792
Reye's syndrome 31.15 11.27 13 1002711 16 63495992
Heparin-induced thrombocytopenia 30.98 11.27 232 1002492 8247 63487761
Metastases to lung 30.91 11.27 127 1002597 15137 63480871
Respiratory distress 30.89 11.27 600 1002124 51731 63444277
Delirium 30.78 11.27 829 1001895 68365 63427643
Face oedema 30.63 11.27 242 1002482 24519 63471489
Virologic failure 30.63 11.27 8 1002716 3458 63492550
Myalgia 30.46 11.27 2863 999861 155754 63340254
Hypercholesterolaemia 30.28 11.27 369 1002355 15004 63481004
Electrocardiogram ST segment elevation 30.23 11.27 205 1002519 7054 63488954
Bradypnoea 29.75 11.27 22 1002702 5137 63490871
Coagulation time abnormal 29.45 11.27 26 1002698 201 63495807
Asthma 29.30 11.27 1196 1001528 94029 63401979
Diastolic dysfunction 29.19 11.27 237 1002487 8638 63487370
Acute lymphocytic leukaemia recurrent 29.16 11.27 13 1002711 4013 63491995
Intermittent claudication 29.07 11.27 109 1002615 2945 63493063
Disturbance in social behaviour 29.03 11.27 12 1002712 3875 63492133
Peptic ulcer 28.99 11.27 162 1002562 5201 63490807
Acute respiratory distress syndrome 28.97 11.27 428 1002296 38507 63457501
Skin toxicity 28.92 11.27 36 1002688 6566 63489442
Ventricular extrasystoles 28.78 11.27 407 1002317 17122 63478886
Blood creatinine increased 28.69 11.27 2468 1000256 133314 63362694
Nasopharyngitis 28.66 11.27 3475 999249 192598 63303410
Metastases to central nervous system 28.65 11.27 115 1002609 13797 63482211
Accidental death 28.64 11.27 11 1002713 3714 63492294
Drug level increased 28.64 11.27 367 1002357 33829 63462179
Thrombotic thrombocytopenic purpura 28.61 11.27 175 1002549 5809 63490199
Post procedural haemorrhage 28.35 11.27 307 1002417 12124 63483884
Localised infection 28.32 11.27 641 1002083 29520 63466488
Traumatic intracranial haemorrhage 28.28 11.27 55 1002669 991 63495017
Blood creatine phosphokinase MB increased 27.88 11.27 97 1002627 2524 63493484
Discomfort 27.86 11.27 1531 1001193 79347 63416661
Sudden cardiac death 27.81 11.27 143 1002581 4444 63491564
Carotid bruit 27.76 11.27 43 1002681 640 63495368
Extrapyramidal disorder 27.61 11.27 184 1002540 19368 63476640
Enterocolitis 27.59 11.27 95 1002629 11923 63484085
Alcohol abuse 27.58 11.27 21 1002703 4831 63491177
Aortic arteriosclerosis 27.56 11.27 205 1002519 7271 63488737
Aortic aneurysm 27.54 11.27 207 1002517 7367 63488641
Blood pressure systolic increased 27.42 11.27 983 1001741 48470 63447538
Coronary angioplasty 27.18 11.27 31 1002693 336 63495672
Diverticulum intestinal 27.09 11.27 203 1002521 7217 63488791
Ischaemia 27.08 11.27 200 1002524 7078 63488930
Aortic valve sclerosis 26.86 11.27 69 1002655 1510 63494498
Pneumatosis intestinalis 26.81 11.27 25 1002699 5204 63490804
Muscular weakness 26.67 11.27 2313 1000411 125025 63370983
Hypokalaemia 26.58 11.27 1587 1001137 120316 63375692
Heart rate decreased 26.58 11.27 1078 1001646 53989 63442019
Pericardial haemorrhage 26.53 11.27 131 1002593 4005 63492003
Hepatic encephalopathy 26.47 11.27 205 1002519 20861 63475147
Hepatitis B 26.47 11.27 50 1002674 7695 63488313
Diffuse large B-cell lymphoma recurrent 26.43 11.27 8 1002716 3138 63492870
Disability assessment scale score increased 26.37 11.27 93 1002631 2437 63493571
Cardiomegaly 26.35 11.27 516 1002208 23168 63472840
Persecutory delusion 26.30 11.27 16 1002708 4142 63491866
Hypoalbuminaemia 26.14 11.27 164 1002560 17510 63478498
Benign prostatic hyperplasia 26.08 11.27 237 1002487 8928 63487080
Gout 26.06 11.27 473 1002251 20940 63475068
Blood calcium increased 25.91 11.27 224 1002500 8318 63487690
Extraocular muscle disorder 25.72 11.27 28 1002696 287 63495721
Recalled product 25.68 11.27 49 1002675 870 63495138
Device related infection 25.53 11.27 329 1002395 30297 63465711
Blood creatine phosphokinase increased 25.49 11.27 1134 1001590 57424 63438584
Psoriasis 25.43 11.27 1361 1001363 70342 63425666
Hypocalcaemia 25.42 11.27 839 1001885 40914 63455094
International normalised ratio decreased 25.31 11.27 201 1002523 7277 63488731
Subdural haemorrhage 25.30 11.27 155 1002569 5148 63490860
Hyponatraemia 25.21 11.27 1974 1000750 146365 63349643
Hyperthermia malignant 25.20 11.27 4 1002720 2455 63493553
Urinary tract infection 24.98 11.27 4032 998692 227564 63268444
Klebsiella infection 24.76 11.27 114 1002610 13167 63482841
Complication of device removal 24.70 11.27 10 1002714 3270 63492738
Leukoencephalopathy 24.68 11.27 44 1002680 6923 63489085
Gastrointestinal ulcer 24.64 11.27 104 1002620 2971 63493037
Device breakage 24.58 11.27 63 1002661 8692 63487316
Bradykinesia 24.55 11.27 40 1002684 6520 63489488
Rotator cuff syndrome 24.46 11.27 292 1002432 11815 63484193
Mitochondrial toxicity 24.38 11.27 6 1002718 2700 63493308
Genital haemorrhage 24.31 11.27 30 1002694 5492 63490516
Erosive duodenitis 24.20 11.27 69 1002655 1609 63494399
Increased tendency to bruise 24.18 11.27 235 1002489 9020 63486988
Cataract 24.16 11.27 1001 1001723 50261 63445747
Toxic epidermal necrolysis 24.16 11.27 419 1002305 36747 63459261
Oculogyric crisis 24.13 11.27 5 1002719 2533 63493475
Arterial restenosis 24.12 11.27 15 1002709 62 63495946
Strongyloidiasis 23.97 11.27 9 1002715 3081 63492927
Bundle branch block left 23.91 11.27 250 1002474 9784 63486224
Helicobacter gastritis 23.91 11.27 82 1002642 2118 63493890
Cardiac arrest 23.78 11.27 2066 1000658 151998 63344010
Intervertebral disc degeneration 23.74 11.27 310 1002414 12810 63483198
Hip arthroplasty 23.70 11.27 465 1002259 20886 63475122
Small intestinal haemorrhage 23.59 11.27 120 1002604 3713 63492295
Juvenile idiopathic arthritis 23.57 11.27 121 1002603 3758 63492250
Candida infection 23.51 11.27 345 1002379 31074 63464934
Accidental exposure to product by child 23.41 11.27 5 1002719 2480 63493528
Hepatitis C 23.35 11.27 90 1002634 10925 63485083
Atrial flutter 23.20 11.27 427 1002297 18953 63477055
Hepatocellular carcinoma 23.19 11.27 61 1002663 8342 63487666
Basal cell carcinoma 23.18 11.27 636 1002088 30202 63465806
Cholelithiasis 23.17 11.27 896 1001828 44610 63451398
Deafness transitory 23.14 11.27 44 1002680 779 63495229
Renal impairment 22.90 11.27 1797 1000927 133220 63362788
Forced expiratory volume decreased 22.88 11.27 45 1002679 6822 63489186
Device leakage 22.81 11.27 60 1002664 8206 63487802
Tetany 22.77 11.27 80 1002644 2092 63493916
Metastases to lymph nodes 22.76 11.27 65 1002659 8652 63487356
Premature delivery 22.75 11.27 411 1002313 18178 63477830
Drug-induced liver injury 22.73 11.27 565 1002159 47078 63448930
Epstein-Barr virus associated lymphoproliferative disorder 22.70 11.27 10 1002714 3109 63492899
Post procedural haematoma 22.69 11.27 83 1002641 2215 63493793
Proteinuria 22.67 11.27 299 1002425 27424 63468584
Progressive multifocal leukoencephalopathy 22.64 11.27 178 1002546 18054 63477954
Condition aggravated 22.63 11.27 5287 997437 367139 63128869
Alcohol interaction 22.62 11.27 21 1002703 4380 63491628
Heart rate irregular 22.52 11.27 572 1002152 26841 63469167
Pneumonia aspiration 22.39 11.27 726 1001998 58545 63437463
Diarrhoea 22.36 11.27 10538 992186 712166 62783842
Hypoxia 22.28 11.27 1131 1001593 87018 63408990
Lipodystrophy acquired 22.17 11.27 18 1002706 4009 63491999
Metabolic alkalosis 22.13 11.27 120 1002604 3808 63492200
Haemodialysis 22.12 11.27 381 1002343 16696 63479312
Blood pressure increased 22.02 11.27 3033 999691 169519 63326489
Muscle rigidity 21.97 11.27 170 1002554 17303 63478705
Nocardiosis 21.94 11.27 25 1002699 4742 63491266
Epistaxis 21.89 11.27 1791 1000933 96340 63399668
Chronic kidney disease 21.88 11.27 1106 1001618 56813 63439195
Cardiotoxicity 21.75 11.27 84 1002640 10190 63485818
Blood prolactin increased 21.73 11.27 14 1002710 3514 63492494
Vascular graft occlusion 21.72 11.27 38 1002686 629 63495379
Mitral valve calcification 21.71 11.27 59 1002665 1337 63494671
Food allergy 21.66 11.27 57 1002667 7794 63488214
Thrombotic stroke 21.62 11.27 39 1002685 662 63495346
Hypothermia 21.46 11.27 201 1002523 19655 63476353
Mediastinal haematoma 21.35 11.27 21 1002703 189 63495819
Dermatitis exfoliative generalised 21.28 11.27 37 1002687 5879 63490129
Rheumatoid factor positive 21.26 11.27 702 1002022 34236 63461772
Blood cholesterol increased 21.23 11.27 967 1001757 49099 63446909
Left ventricular failure 21.15 11.27 212 1002512 8205 63487803
Coronary artery aneurysm 21.11 11.27 17 1002707 114 63495894
Oesophageal ulcer 21.06 11.27 167 1002557 6043 63489965
Asthenia 21.05 11.27 7189 995535 420855 63075153
Fungal infection 21.05 11.27 390 1002334 33861 63462147
Bacteraemia 21.01 11.27 293 1002431 26618 63469390
Arterial stenosis 21.01 11.27 58 1002666 1327 63494681
Blood pressure diastolic decreased 20.95 11.27 474 1002250 21827 63474181
Red blood cell sedimentation rate abnormal 20.84 11.27 363 1002361 15943 63480065
Metabolic acidosis 20.82 11.27 896 1001828 70062 63425946
Skin laceration 20.80 11.27 512 1002212 23905 63472103
Muscle haemorrhage 20.78 11.27 157 1002567 5596 63490412
Red blood cell count decreased 20.61 11.27 935 1001789 47451 63448557
Psoriatic arthropathy 20.59 11.27 846 1001878 42435 63453573
Diabetic foot 20.59 11.27 97 1002627 2908 63493100
Wrong patient received product 20.48 11.27 17 1002707 3745 63492263
Nephropathy toxic 20.37 11.27 174 1002550 17340 63478668
Psychomotor skills impaired 20.17 11.27 18 1002706 3827 63492181
Page kidney 20.16 11.27 13 1002711 58 63495950
Electrocardiogram ST segment depression 20.13 11.27 127 1002597 4262 63491746
Arterial occlusive disease 20.08 11.27 182 1002542 6851 63489157
Ecchymosis 20.07 11.27 318 1002406 13704 63482304
Cell death 20.07 11.27 20 1002704 4034 63491974
Lactic acidosis 20.03 11.27 766 1001958 60644 63435364
Generalised tonic-clonic seizure 20.02 11.27 469 1002255 39388 63456620
Helicobacter test positive 19.98 11.27 48 1002676 1006 63495002
Pulmonary calcification 19.94 11.27 27 1002697 353 63495655
Catheter site haematoma 19.76 11.27 26 1002698 330 63495678
Coronary artery insufficiency 19.75 11.27 19 1002705 166 63495842
Mallory-Weiss syndrome 19.65 11.27 86 1002638 2497 63493511
Carotid arteriosclerosis 19.62 11.27 74 1002650 2005 63494003
Lung disorder 19.61 11.27 758 1001966 59942 63436066
Oesophagitis haemorrhagic 19.47 11.27 34 1002690 562 63495446
Hypogammaglobulinaemia 19.44 11.27 88 1002636 10211 63485797
Caesarean section 19.41 11.27 264 1002460 11010 63484998
Troponin increased 19.39 11.27 342 1002382 15057 63480951
Systemic mycosis 19.35 11.27 6 1002718 2317 63493691
Cardiac tamponade 19.26 11.27 203 1002521 7961 63488047
Calciphylaxis 19.22 11.27 102 1002622 3210 63492798
Aneurysm 19.19 11.27 95 1002629 2907 63493101
Sinus bradycardia 19.19 11.27 479 1002245 22414 63473594
Pneumonia fungal 19.16 11.27 72 1002652 8805 63487203
Cardiac stress test abnormal 19.09 11.27 38 1002686 697 63495311
Myocarditis 19.08 11.27 171 1002553 16872 63479136
Deep vein thrombosis 19.07 11.27 1891 1000833 103291 63392717
Hip fracture 19.01 11.27 554 1002170 26545 63469463
Knee arthroplasty 18.95 11.27 552 1002172 26447 63469561
Mood altered 18.92 11.27 158 1002566 15821 63480187
Body temperature increased 18.82 11.27 430 1002294 36236 63459772
Anxiety 18.81 11.27 2813 999911 199836 63296172
Gastrointestinal arteriovenous malformation 18.67 11.27 43 1002681 876 63495132
Acute myeloid leukaemia recurrent 18.63 11.27 10 1002714 2774 63493234
Cross sensitivity reaction 18.60 11.27 15 1002709 3352 63492656
Percutaneous coronary intervention 18.51 11.27 25 1002699 326 63495682
Hepatic cytolysis 18.47 11.27 135 1002589 13914 63482094
Laryngeal pain 18.45 11.27 151 1002573 5517 63490491
Product quality issue 18.40 11.27 339 1002385 29460 63466548
Drug dose omission by device 18.36 11.27 16 1002708 3441 63492567
Intracranial aneurysm 18.35 11.27 108 1002616 3535 63492473
Joint laxity 18.34 11.27 78 1002646 2236 63493772
Atrioventricular block first degree 18.34 11.27 251 1002473 10483 63485525
Live birth 18.34 11.27 260 1002464 10944 63485064
Pruritus 18.32 11.27 4442 998282 307958 63188050
Coeliac disease 18.11 11.27 57 1002667 7355 63488653
Neutropenic colitis 18.03 11.27 27 1002697 4554 63491454
Hypertensive heart disease 18.03 11.27 111 1002613 3693 63492315
Enthesopathy 17.98 11.27 229 1002495 9409 63486599
Pericardial rub 17.92 11.27 8 1002716 13 63495995
Aortic valve disease 17.86 11.27 60 1002664 1533 63494475
Hemiparesis 17.81 11.27 598 1002126 29229 63466779
Psychiatric decompensation 17.77 11.27 8 1002716 2455 63493553
Blood homocysteine increased 17.75 11.27 25 1002699 340 63495668
Skin flap necrosis 17.72 11.27 10 1002714 33 63495975
Pregnancy with contraceptive device 17.71 11.27 14 1002710 3160 63492848
Mitral valve prolapse 17.70 11.27 68 1002656 1859 63494149
Systemic candida 17.69 11.27 35 1002689 5294 63490714
Pneumonia cytomegaloviral 17.64 11.27 25 1002699 4314 63491694
Amenorrhoea 17.64 11.27 48 1002676 6491 63489517
Myopathy 17.63 11.27 379 1002345 17301 63478707
Shunt thrombosis 17.60 11.27 15 1002709 110 63495898
Low density lipoprotein increased 17.58 11.27 191 1002533 7549 63488459
Swelling 17.56 11.27 2792 999932 157426 63338582
Otitis media staphylococcal 17.51 11.27 7 1002717 7 63496001
Naevus flammeus 17.51 11.27 13 1002711 76 63495932
Sedation complication 17.50 11.27 92 1002632 10262 63485746
Platelet aggregation increased 17.49 11.27 15 1002709 111 63495897
Eye haemorrhage 17.49 11.27 203 1002521 8157 63487851
Type V hyperlipidaemia 17.49 11.27 42 1002682 880 63495128
Rebound effect 17.46 11.27 31 1002693 4886 63491122
Cytopenia 17.42 11.27 155 1002569 15316 63480692
COVID-19 17.39 11.27 831 1001893 64309 63431699
Fracture delayed union 17.38 11.27 69 1002655 1916 63494092
Extradural haematoma 17.34 11.27 85 1002639 2591 63493417
Coronary artery surgery 17.33 11.27 18 1002706 174 63495834
Renal cyst 17.22 11.27 283 1002441 12287 63483721
Vitreous haemorrhage 17.22 11.27 94 1002630 2991 63493017
Pneumonia bacterial 17.21 11.27 150 1002574 14885 63481123
Pneumomediastinum 17.20 11.27 12 1002712 2888 63493120
Blood glucose increased 17.18 11.27 1759 1000965 96314 63399694
Diverticulum intestinal haemorrhagic 17.17 11.27 98 1002626 3171 63492837
Gastrointestinal angiodysplasia 17.16 11.27 42 1002682 891 63495117
Puncture site haemorrhage 17.16 11.27 31 1002693 527 63495481
Hyperpyrexia 17.15 11.27 33 1002691 5044 63490964
Ischaemic stroke 17.05 11.27 581 1002143 28454 63467554
Splenic rupture 16.97 11.27 74 1002650 2145 63493863
Psychotic symptom 16.97 11.27 6 1002718 2132 63493876
Adjustment disorder 16.94 11.27 86 1002638 2659 63493349
Electrocardiogram Q wave abnormal 16.93 11.27 26 1002698 384 63495624
Procedural complication 16.84 11.27 180 1002544 7085 63488923
Cerebral arteriosclerosis 16.82 11.27 37 1002687 730 63495278
Sputum increased 16.80 11.27 19 1002705 3616 63492392
Arterial stent insertion 16.75 11.27 13 1002711 82 63495926
Pre-eclampsia 16.66 11.27 159 1002565 6072 63489936
Calcification metastatic 16.61 11.27 7 1002717 9 63495999
Peritonitis bacterial 16.50 11.27 214 1002510 8829 63487179
Sinus arrest 16.48 11.27 93 1002631 2997 63493011
Urinary bladder haemorrhage 16.41 11.27 76 1002648 2262 63493746
Cerebral infarction 16.39 11.27 788 1001936 40256 63455752
Embolic stroke 16.37 11.27 168 1002556 6543 63489465
Product preparation error 16.36 11.27 23 1002701 3982 63492026
Renal haemorrhage 16.36 11.27 67 1002657 1888 63494120
Malignant melanoma 16.35 11.27 288 1002436 12676 63483332
Erosive oesophagitis 16.33 11.27 82 1002642 2524 63493484
Disease recurrence 16.32 11.27 369 1002355 31141 63464867
Hepatic enzyme increased 16.32 11.27 2282 1000442 127661 63368347
Stress fracture 16.29 11.27 146 1002578 5478 63490530
Shock 16.27 11.27 461 1002263 37779 63458229
Metabolic disorder 16.25 11.27 63 1002661 7634 63488374
Impaired healing 16.22 11.27 1120 1001604 59353 63436655
Fungaemia 16.21 11.27 21 1002703 3764 63492244
Adrenal insufficiency 16.11 11.27 249 1002475 22238 63473770
Vascular graft complication 15.95 11.27 15 1002709 127 63495881
Spinal epidural haematoma 15.94 11.27 49 1002675 1193 63494815
Eye excision 15.92 11.27 12 1002712 72 63495936
Joint effusion 15.83 11.27 296 1002428 13177 63482831
Paronychia 15.81 11.27 50 1002674 6442 63489566
Terminal state 15.80 11.27 28 1002696 4416 63491592
Affective disorder 15.80 11.27 51 1002673 6529 63489479
Drug eruption 15.79 11.27 434 1002290 35702 63460306
Vertebral artery stenosis 15.78 11.27 17 1002707 172 63495836
Myocardial rupture 15.72 11.27 19 1002705 220 63495788
Bacterial infection 15.67 11.27 283 1002441 24667 63471341
Cardiac valve disease 15.64 11.27 136 1002588 5059 63490949
Nephrocalcinosis 15.63 11.27 51 1002673 1283 63494725
Infection reactivation 15.60 11.27 6 1002718 2024 63493984
Inappropriate antidiuretic hormone secretion 15.56 11.27 248 1002476 22041 63473967
Embedded device 15.53 11.27 12 1002712 2740 63493268
Antinuclear antibody positive 15.50 11.27 157 1002567 6093 63489915
Dementia Alzheimer's type 15.50 11.27 42 1002682 950 63495058
Clostridium difficile colitis 15.50 11.27 314 1002410 26909 63469099
Barrett's oesophagus 15.45 11.27 36 1002688 739 63495269
Granulomatous pneumonitis 15.39 11.27 11 1002713 60 63495948
Renal tubular disorder 15.37 11.27 45 1002679 5942 63490066
Electrocardiogram ST-T change 15.34 11.27 56 1002668 1493 63494515
Anaemia postoperative 15.31 11.27 61 1002663 1697 63494311
Musculoskeletal discomfort 15.30 11.27 346 1002378 15931 63480077
Right ventricular failure 15.30 11.27 238 1002486 21233 63474775
Choroidal dystrophy 15.28 11.27 10 1002714 46 63495962
Silent myocardial infarction 15.27 11.27 33 1002691 643 63495365
Coronary ostial stenosis 15.25 11.27 15 1002709 135 63495873
Back disorder 15.23 11.27 229 1002495 9761 63486247
Anion gap 15.23 11.27 5 1002719 1862 63494146
Cardiac operation 15.22 11.27 115 1002609 4099 63491909
Varicella zoster virus infection 15.22 11.27 23 1002701 3865 63492143
Costochondritis 15.21 11.27 68 1002656 1993 63494015
Oesophagitis 15.12 11.27 442 1002282 21188 63474820
Carpal tunnel syndrome 15.05 11.27 337 1002387 15491 63480517
Immune effector cell-associated neurotoxicity syndrome 15.05 11.27 11 1002713 2584 63493424
Otitis media bacterial 15.01 11.27 6 1002718 6 63496002
Lung neoplasm 14.98 11.27 157 1002567 6148 63489860
Tenderness 14.94 11.27 405 1002319 19197 63476811
Corneal oedema 14.84 11.27 9 1002715 2334 63493674
Basal ganglia infarction 14.82 11.27 29 1002695 525 63495483
Neurologic neglect syndrome 14.78 11.27 57 1002667 1561 63494447
Pelvic pain 14.75 11.27 104 1002620 10806 63485202
Chromaturia 14.71 11.27 458 1002266 22153 63473855
Acute graft versus host disease in liver 14.71 11.27 4 1002720 1683 63494325
Galactorrhoea 14.69 11.27 17 1002707 3202 63492806
Pseudomonal sepsis 14.69 11.27 37 1002687 5135 63490873
Drug abuser 14.66 11.27 44 1002680 5764 63490244
Peripheral sensory neuropathy 14.64 11.27 110 1002614 11268 63484740
Carotid artery thrombosis 14.61 11.27 61 1002663 1734 63494274
Product administered to patient of inappropriate age 14.61 11.27 31 1002693 4570 63491438
Aplastic anaemia 14.58 11.27 142 1002582 13778 63482230
Steroid diabetes 14.57 11.27 12 1002712 2654 63493354
Myelodysplastic syndrome 14.56 11.27 322 1002402 27257 63468751
Crying 14.55 11.27 222 1002502 19868 63476140
Hepatotoxicity 14.50 11.27 492 1002232 39470 63456538
Mental disorder 14.47 11.27 307 1002417 26138 63469870
Diverticulitis intestinal haemorrhagic 14.47 11.27 26 1002698 440 63495568
Cognitive disorder 14.46 11.27 704 1002020 54383 63441625
Nocturia 14.43 11.27 249 1002475 10916 63485092
Weight decreased 14.41 11.27 4804 997920 280935 63215073
Twin pregnancy 14.39 11.27 37 1002687 810 63495198
Skin cancer 14.39 11.27 264 1002460 11710 63484298
Product use issue 14.30 11.27 2104 1000620 149611 63346397
Enterococcal infection 14.29 11.27 142 1002582 13724 63482284
Nicotine dependence 14.29 11.27 36 1002688 778 63495230
Hypernatraemia 14.22 11.27 121 1002603 12068 63483940
Diabetic ketoacidosis 14.21 11.27 354 1002370 29491 63466517
Osteoporosis 14.18 11.27 795 1001929 41285 63454723
Occult blood 14.15 11.27 51 1002673 1351 63494657
Essential hypertension 14.12 11.27 133 1002591 5061 63490947
Arteriogram coronary abnormal 14.12 11.27 6 1002718 8 63496000
Cerebral artery occlusion 14.11 11.27 56 1002668 1555 63494453
Rectal polyp 14.08 11.27 48 1002676 1236 63494772
Arthritis 14.07 11.27 1499 1001225 82315 63413693
QRS axis abnormal 14.03 11.27 61 1002663 1766 63494242
Arteriovenous malformation 13.98 11.27 55 1002669 1521 63494487
Bacterial sepsis 13.91 11.27 64 1002660 7393 63488615
Hungry bone syndrome 13.83 11.27 15 1002709 153 63495855
Myositis 13.83 11.27 343 1002381 16034 63479974
Blood potassium increased 13.81 11.27 514 1002210 25466 63470542
Vascular calcification 13.80 11.27 40 1002684 942 63495066
Tendonitis 13.78 11.27 413 1002311 19869 63476139
Peripheral artery aneurysm 13.77 11.27 23 1002701 366 63495642
Electrocardiogram abnormal 13.77 11.27 290 1002434 13191 63482817
Left ventricular hypertrophy 13.76 11.27 216 1002508 9290 63486718
Cardiac aneurysm 13.75 11.27 48 1002676 1251 63494757
Cystic fibrosis 13.75 11.27 20 1002704 3414 63492594
Abortion spontaneous 13.74 11.27 499 1002225 24644 63471364
Blood pressure inadequately controlled 13.72 11.27 136 1002588 5248 63490760
Hyphaema 13.70 11.27 31 1002693 624 63495384
Joint injury 13.69 11.27 460 1002264 22487 63473521
Nephrogenic systemic fibrosis 13.66 11.27 146 1002578 5746 63490262
Blood glucose decreased 13.66 11.27 463 1002261 22660 63473348
Lumbar spinal stenosis 13.62 11.27 121 1002603 4529 63491479
Acute kidney injury 13.62 11.27 6554 996170 442686 63053322
Toxic encephalopathy 13.54 11.27 93 1002631 9722 63486286
Paranoia 13.50 11.27 176 1002548 16176 63479832
Ventricular fibrillation 13.40 11.27 475 1002249 23385 63472623
Tympanic membrane perforation 13.39 11.27 50 1002674 1348 63494660
Wrong technique in device usage process 13.39 11.27 15 1002709 2867 63493141
Anaemia 13.36 11.27 6287 996437 372393 63123615
Obliterative bronchiolitis 13.36 11.27 13 1002711 2652 63493356
Mood swings 13.35 11.27 191 1002533 17277 63478731
Liver abscess 13.33 11.27 40 1002684 5240 63490768
High density lipoprotein decreased 13.32 11.27 106 1002618 3840 63492168
Squamous cell carcinoma of skin 13.30 11.27 259 1002465 11617 63484391
Immune-mediated enterocolitis 13.27 11.27 13 1002711 2643 63493365
Generalised oedema 13.26 11.27 236 1002488 20617 63475391
Dieulafoy's vascular malformation 13.25 11.27 8 1002716 31 63495977
Coronary artery perforation 13.19 11.27 11 1002713 78 63495930
Colonic haematoma 13.19 11.27 11 1002713 78 63495930
Cerebral ischaemia 13.17 11.27 223 1002501 9739 63486269
Cerebellar haemorrhage 13.17 11.27 78 1002646 2559 63493449
Stomatitis 13.13 11.27 1497 1001227 108108 63387900
Diabetes insipidus 13.11 11.27 32 1002692 4489 63491519
Cerebral toxoplasmosis 13.06 11.27 6 1002718 1820 63494188
Device malfunction 13.06 11.27 194 1002530 17439 63478569
Neck deformity 13.03 11.27 57 1002667 1655 63494353
Spinal cord herniation 13.02 11.27 5 1002719 4 63496004
Pericardial disease 13.02 11.27 26 1002698 478 63495530
Supraventricular extrasystoles 12.99 11.27 145 1002579 5770 63490238
Coronary artery reocclusion 12.97 11.27 14 1002710 142 63495866
Aneurysm ruptured 12.95 11.27 36 1002688 827 63495181
Rash morbilliform 12.94 11.27 39 1002685 5102 63490906
Euglycaemic diabetic ketoacidosis 12.94 11.27 42 1002682 5368 63490640
Anuria 12.91 11.27 212 1002512 18752 63477256
Tenosynovitis 12.89 11.27 257 1002467 11576 63484432
Hand-eye coordination impaired 12.88 11.27 7 1002717 21 63495987
Insomnia 12.87 11.27 2799 999925 195037 63300971
Precancerous skin lesion 12.77 11.27 43 1002681 1100 63494908
Hypertriglyceridaemia 12.73 11.27 112 1002612 11093 63484915
Abdominal pain 12.71 11.27 4510 998214 307865 63188143
Drug screen positive 12.67 11.27 46 1002678 5683 63490325
Dependence 12.67 11.27 9 1002715 2146 63493862
Small intestine polyp 12.65 11.27 7 1002717 22 63495986
Aortic valve calcification 12.63 11.27 31 1002693 659 63495349
Meningitis cryptococcal 12.57 11.27 17 1002707 2992 63493016
Coronary artery embolism 12.54 11.27 19 1002705 277 63495731
Fat embolism 12.54 11.27 22 1002702 365 63495643
Obsessive-compulsive disorder 12.53 11.27 36 1002688 4782 63491226
Peritoneal dialysis complication 12.51 11.27 68 1002656 2160 63493848
Subcapsular renal haematoma 12.48 11.27 31 1002693 664 63495344
Infection 12.47 11.27 2611 1000113 182269 63313739
Activated partial thromboplastin time prolonged 12.46 11.27 274 1002450 12557 63483451
Haptoglobin increased 12.46 11.27 15 1002709 173 63495835
Encephalitis 12.44 11.27 130 1002594 12441 63483567
Vascular procedure complication 12.43 11.27 7 1002717 23 63495985
Polycythaemia vera 12.40 11.27 18 1002706 252 63495756
Pneumonia viral 12.40 11.27 71 1002653 7751 63488257
Device interaction 12.39 11.27 31 1002693 667 63495341
Stevens-Johnson syndrome 12.35 11.27 422 1002302 33827 63462181
Hyperammonaemic encephalopathy 12.34 11.27 28 1002696 4030 63491978
Graft thrombosis 12.34 11.27 23 1002701 401 63495607
Diverticulitis 12.32 11.27 726 1001998 37892 63458116
Extremity contracture 12.28 11.27 54 1002670 1571 63494437
Pelvic haematoma 12.25 11.27 31 1002693 672 63495336
Large intestinal ulcer 12.22 11.27 109 1002615 4084 63491924
Brain stem stroke 12.22 11.27 23 1002701 404 63495604
Aortic valve replacement 12.21 11.27 43 1002681 1126 63494882
Pedal pulse decreased 12.20 11.27 9 1002715 52 63495956
Bundle branch block right 12.20 11.27 226 1002498 10043 63485965
Cryptococcosis 12.09 11.27 15 1002709 2740 63493268
Blood HIV RNA increased 12.06 11.27 4 1002720 1480 63494528
Tongue haematoma 12.05 11.27 16 1002708 205 63495803
Dyskinesia 12.05 11.27 495 1002229 38893 63457115
Neoplasm recurrence 12.03 11.27 25 1002699 3714 63492294
Metastases to peritoneum 12.03 11.27 23 1002701 3524 63492484
Gastritis haemorrhagic 12.01 11.27 68 1002656 2194 63493814
Blood sodium decreased 11.97 11.27 567 1002157 28915 63467093
Foetal growth restriction 11.97 11.27 56 1002668 1674 63494334
Middle ear effusion 11.90 11.27 62 1002662 1937 63494071
Brain stem infarction 11.88 11.27 58 1002666 1765 63494243
Salivary gland calculus 11.87 11.27 17 1002707 235 63495773
Bone disorder 11.86 11.27 343 1002381 16416 63479592
Bleeding time prolonged 11.85 11.27 43 1002681 1143 63494865
Tremor 11.85 11.27 2075 1000649 146155 63349853
Body height decreased 11.85 11.27 174 1002550 7380 63488628
Liver function test abnormal 11.81 11.27 1075 1001649 58326 63437682
Brain abscess 11.81 11.27 30 1002694 4151 63491857
Premature rupture of membranes 11.79 11.27 99 1002625 3645 63492363
Infusion site pain 11.78 11.27 104 1002620 10293 63485715
Ototoxicity 11.77 11.27 15 1002709 2708 63493300
Erectile dysfunction 11.74 11.27 268 1002456 12359 63483649
Clavicle fracture 11.74 11.27 99 1002625 3650 63492358
Colorectal cancer 11.72 11.27 20 1002704 3201 63492807
Calcium ionised increased 11.72 11.27 14 1002710 160 63495848
Diabetic retinopathy 11.72 11.27 80 1002644 2759 63493249
Skin plaque 11.71 11.27 86 1002638 8854 63487154
Medication error 11.70 11.27 646 1002078 49320 63446688
Accelerated hypertension 11.68 11.27 28 1002696 586 63495422
Akinesia 11.68 11.27 85 1002639 2994 63493014
Thalamus haemorrhage 11.64 11.27 53 1002671 1566 63494442
Angiogram abnormal 11.61 11.27 7 1002717 27 63495981
Gastrointestinal toxicity 11.60 11.27 43 1002681 5279 63490729
Grip strength decreased 11.59 11.27 251 1002473 11473 63484535
Hereditary angioedema 11.58 11.27 27 1002697 3849 63492159
Hypercapnia 11.58 11.27 71 1002653 7623 63488385
Diffuse large B-cell lymphoma 11.58 11.27 104 1002620 10257 63485751
Prescription drug used without a prescription 11.58 11.27 14 1002710 2586 63493422
Hemiplegia 11.57 11.27 270 1002454 12498 63483510
Open reduction of fracture 11.55 11.27 16 1002708 214 63495794
Pharyngeal haemorrhage 11.52 11.27 43 1002681 1159 63494849
Dilatation ventricular 11.49 11.27 101 1002623 3769 63492239
Fusarium infection 11.47 11.27 5 1002719 1564 63494444
Blood pressure fluctuation 11.45 11.27 946 1001778 50925 63445083
Post procedural myocardial infarction 11.43 11.27 8 1002716 42 63495966
Product substitution issue 11.41 11.27 202 1002522 17659 63478349
Tooth disorder 11.38 11.27 441 1002283 21961 63474047
Skin ulcer 11.37 11.27 812 1001912 43162 63452846
Foot fracture 11.35 11.27 366 1002358 17791 63478217
Salivary hypersecretion 11.29 11.27 127 1002597 11986 63484022
Groin pain 11.29 11.27 244 1002480 11149 63484859
Puncture site reaction 11.28 11.27 6 1002718 17 63495991

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AC01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Calcium compounds
ATC A12AA04 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:65265 antacids
CHEBI has role CHEBI:77182 food coloring
CHEBI has role CHEBI:77960 firming agents
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Indigestion indication 162031009
Heartburn Prevention indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
H0G9379FGK UNII
4019035 VUID
N0000147306 NUI
4017644 VANDF
4019033 VANDF
4019035 VANDF
C0006681 UMLSCUI
CHEBI:3311 CHEBI
CHEMBL1200539 ChEMBL_ID
10112 PUBCHEM_CID
DB06724 DRUGBANK_ID
D002119 MESH_DESCRIPTOR_UI
1897 RXNORM
10153 MMSL
4326 MMSL
4330 MMSL
6070 MMSL
d00425 MMSL
000773 NDDF
001117 NDDF
387307005 SNOMEDCT_US
55217007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0054-3117 SUSPENSION 1250 mg ORAL OTC monograph final 11 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 14 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
good sense antacid HUMAN OTC DRUG LABEL 1 0113-0962 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 11 sections
good sense antacid HUMAN OTC DRUG LABEL 1 0113-0962 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 11 sections
basic care dual action complete HUMAN OTC DRUG LABEL 3 0113-7321 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
basic care dual action complete HUMAN OTC DRUG LABEL 3 0113-7321 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC monograph final 13 sections
PHAZYME HUMAN OTC DRUG LABEL 2 0132-0507 TABLET, CHEWABLE 750 mg ORAL OTC monograph final 11 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0070 TABLET 500 mg ORAL OTC monograph final 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0070 TABLET 500 mg ORAL OTC monograph final 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0071 TABLET 500 mg ORAL OTC monograph final 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0071 TABLET 500 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0074 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0074 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0076 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0076 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSULTRA HUMAN OTC DRUG LABEL 1 0135-0118 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 12 sections
TUMSULTRA HUMAN OTC DRUG LABEL 1 0135-0118 TABLET, CHEWABLE 1000 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0140 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0140 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0154 TABLET 750 mg ORAL OTC monograph final 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0154 TABLET 750 mg ORAL OTC monograph final 12 sections