titanium dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4237	13463-67-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: titanium dioxide titanium oxide	used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure Molecular weight: 79.87 Formula: O2Ti CLOGP: -1.32 LIPINSKI: None HAC: 2 HDO: 0 TPSA: 34.14 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

titanium dioxide
titanium oxide

used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure

Molecular weight: 79.87
Formula: O2Ti
CLOGP: -1.32
LIPINSKI: None
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 5, 2006	FDA	LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	901.62	22.43	224	3747	24152	63460899
Chronic sinusitis	280.47	22.43	78	3893	12765	63472286
Paraesthesia oral	245.09	22.43	77	3894	19179	63465872
Procedural pain	236.49	22.43	77	3894	21492	63463559
Drug ineffective	162.23	22.43	255	3716	1044510	62440541
Therapeutic product effect incomplete	136.08	22.43	89	3882	124967	63360084
Vaginal flatulence	134.87	22.43	33	3938	3260	63481791
Dyspepsia	126.70	22.43	79	3892	102117	63382934
Proctitis	118.43	22.43	33	3938	5408	63479643
Female genital tract fistula	116.28	22.43	35	3936	7524	63477527
Radiculopathy	103.48	22.43	33	3938	8578	63476473
Vaginal discharge	101.34	22.43	33	3938	9165	63475886
Colitis ulcerative	74.07	22.43	35	3936	26056	63458995
Oral candidiasis	72.23	22.43	33	3938	22765	63462286
Pyrexia	72.11	22.43	115	3856	470363	63014688
Frequent bowel movements	71.92	22.43	33	3938	22989	63462062
Weight decreased	69.76	22.43	86	3885	276712	63208339
Infusion related reaction	62.98	22.43	77	3894	245444	63239607
Colitis	56.21	22.43	36	3935	48492	63436559
Rectal haemorrhage	55.87	22.43	36	3935	48994	63436057
Haematochezia	52.98	22.43	36	3935	53508	63431543
Malaise	38.55	22.43	82	3889	415872	63069179
Nausea	34.45	22.43	124	3847	854347	62630704
Constipation	25.12	22.43	48	3923	224895	63260156

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	94.12	26.72	20	1785	1280	34953846
SARS-CoV-2 test negative	81.34	26.72	17	1788	1003	34954123
Accident	67.18	26.72	20	1785	5027	34950099
Proctalgia	64.70	26.72	20	1785	5703	34949423
Haemorrhoids	49.77	26.72	21	1784	14554	34940572
Body temperature increased	46.23	26.72	21	1784	17347	34937779
Appendicolith	41.86	26.72	16	1789	8585	34946541
Ascites	33.75	26.72	24	1781	46547	34908579
Appendicitis	33.49	26.72	16	1789	14791	34940335
Ventricular fibrillation	29.53	26.72	17	1788	22937	34932189
Febrile neutropenia	28.29	26.72	35	1770	136814	34818312
Cardiogenic shock	27.20	26.72	17	1788	26601	34928525

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	266.93	21.61	74	5229	11222	79727863
Chronic sinusitis	260.97	21.61	75	5228	12951	79726134
Paraesthesia oral	223.54	21.61	74	5229	20397	79718688
Procedural pain	214.82	21.61	74	5229	23010	79716075
Vaginal flatulence	135.64	21.61	32	5271	2543	79736542
Therapeutic product effect incomplete	120.90	21.61	89	5214	141556	79597529
Female genital tract fistula	117.78	21.61	34	5269	5941	79733144
Dyspepsia	112.86	21.61	77	5226	108610	79630475
Proctitis	106.60	21.61	32	5271	6400	79732685
Vaginal discharge	101.91	21.61	32	5271	7431	79731654
Radiculopathy	96.64	21.61	32	5271	8792	79730293
Anal inflammation	81.78	21.61	19	5284	1411	79737674
Pyrexia	76.34	21.61	150	5153	678559	79060526
SARS-CoV-2 test negative	66.80	21.61	16	5287	1355	79737730
Infusion related reaction	63.05	21.61	77	5226	230160	79508925
Frequent bowel movements	62.16	21.61	33	5270	29506	79709579
Colitis ulcerative	59.83	21.61	34	5269	34708	79704377
Oral candidiasis	59.26	21.61	32	5271	29596	79709489
Weight decreased	58.53	21.61	93	5210	355105	79383980
Proctalgia	48.77	21.61	20	5283	9981	79729104
Malaise	48.62	21.61	103	5200	489766	79249319
Accident	47.68	21.61	19	5284	8812	79730273
Rectal haemorrhage	43.69	21.61	38	5265	76262	79662823
Constipation	43.69	21.61	72	5231	282978	79456107
Colitis	42.97	21.61	37	5266	73270	79665815
Haematochezia	39.17	21.61	38	5265	87607	79651478
Appendicolith	37.99	21.61	16	5287	8535	79730550
Nausea	36.18	21.61	142	5161	957054	78782031
Pain	33.83	21.61	113	5190	703689	79035396
Haemorrhoids	28.66	21.61	20	5283	29108	79709977
Off label use	24.61	21.61	122	5181	907093	78831992
Appendicitis	24.58	21.61	16	5287	20778	79718307
Body temperature increased	23.17	21.61	21	5282	44399	79694686
Abdominal pain	22.73	21.61	67	5236	389502	79349583
Febrile neutropenia	22.15	21.61	48	5255	230951	79508134
Ascites	21.80	21.61	26	5277	75536	79663549

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D001672	Biocompatible Materials
MeSH PA	D004396	Coloring Agents
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D017319	Photosensitizing Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D011838	Radiation-Sensitizing Agents
MeSH PA	D013473	Sunscreening Agents
CHEBI has role	CHEBI:77182	food coloring

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
15FIX9V2JP	UNII
4019139	VUID
N0000179267	NUI
D01931	KEGG_DRUG
4019139	VANDF
C0076733	UMLSCUI
CHEBI:32234	CHEBI
CHEMBL1201136	ChEMBL_ID
26042	PUBCHEM_CID
DB09536	DRUGBANK_ID
C009495	MESH_SUPPLEMENTAL_RECORD_UI
38323	RXNORM
NOCODE	MMSL
001911	NDDF
432929006	SNOMEDCT_US
62036000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted)	HUMAN OTC DRUG LABEL	4	0023-5497	LOTION	35 mg	TOPICAL	OTC monograph not final	12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted)	HUMAN OTC DRUG LABEL	4	0023-5497	LOTION	35 mg	TOPICAL	OTC monograph not final	12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5675	LOTION	50 mg	TOPICAL	OTC monograph not final	12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5675	LOTION	50 mg	TOPICAL	OTC monograph not final	12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5703	LOTION	50 mg	TOPICAL	OTC monograph not final	7 sections
Solbar Shield SPF40	HUMAN OTC DRUG LABEL	2	0096-0682	CREAM	0.05 g	TOPICAL	OTC monograph final	8 sections
Solbar Shield SPF40	HUMAN OTC DRUG LABEL	2	0096-0682	CREAM	0.05 g	TOPICAL	OTC monograph final	8 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50	HUMAN OTC DRUG LABEL	2	0299-4108	STICK	60 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50	HUMAN OTC DRUG LABEL	2	0299-4108	STICK	60 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30	HUMAN OTC DRUG LABEL	2	0299-4111	LOTION	30 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30	HUMAN OTC DRUG LABEL	2	0299-4111	LOTION	30 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50	HUMAN OTC DRUG LABEL	2	0299-4112	LOTION	49 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50	HUMAN OTC DRUG LABEL	2	0299-4122	LOTION	90 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50	HUMAN OTC DRUG LABEL	2	0299-4122	LOTION	90 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 40	HUMAN OTC DRUG LABEL	2	0299-4138	CREAM	101 mg	TOPICAL	OTC monograph final	9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	57 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	57 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20	HUMAN OTC DRUG LABEL	2	0299-5889	CREAM	101 mg	TOPICAL	OTC monograph final	9 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20	HUMAN OTC DRUG LABEL	2	0299-5889	CREAM	101 mg	TOPICAL	OTC monograph final	9 sections
Almay Line Smoothing Liquid Make-Up for Dry Skin	HUMAN OTC DRUG LABEL	2	0311-0700	LIQUID	4.70 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade Skintone Matching Makeup	HUMAN OTC DRUG LABEL	2	0311-0701	LIQUID	4.80 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade Skintone Anti- Aging Make-Up	HUMAN OTC DRUG LABEL	2	0311-0702	LIQUID	3.90 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade Smart Balance Make-Up	HUMAN OTC DRUG LABEL	2	0311-0703	LIQUID	3.80 mg	TOPICAL	OTC monograph final	8 sections
Almay Wake-Up Liquid Make-Up	HUMAN OTC DRUG LABEL	2	0311-0704	LIQUID	9 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade CC Cream	HUMAN OTC DRUG LABEL	3	0311-0705	LIQUID	5.10 mg	TOPICAL	OTC monograph final	6 sections
Almay Age Smart Shade CC Luminous Primer SPF 15	HUMAN OTC DRUG LABEL	2	0311-0706	LIQUID	4.30 mg	TOPICAL	OTC monograph final	8 sections
Almay Age Essentials Makeup SPF 15	HUMAN OTC DRUG LABEL	2	0311-0707	LIQUID	4.30 mg	TOPICAL	OTC monograph final	8 sections
ALMAY SMART SHADE ANTI-AGING SKINTONE MATCHING MAKEUP SPF 20	HUMAN OTC DRUG LABEL	2	0311-0710	LIQUID	5.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	5.30 mg	TOPICAL	OTC monograph final	5 sections
Almay Healthy Biome Makeup	HUMAN OTC DRUG LABEL	5	0311-0723	EMULSION	5.80 mg	TOPICAL	OTC monograph final	7 sections