titanium dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4237 13463-67-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • titanium dioxide
  • titanium oxide
used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure
  • Molecular weight: 79.87
  • Formula: O2Ti
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 2006 FDA LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 508.04 21.39 114 1662 14274 50589074
Drug ineffective 97.88 21.39 130 1646 819203 49784145
Chronic sinusitis 28.61 21.39 10 1766 6135 50597213
Jarisch-Herxheimer reaction 25.92 21.39 5 1771 290 50603058
Paraesthesia oral 25.15 21.39 11 1765 12210 50591138
Dermatophytosis 22.28 21.39 4 1772 156 50603192

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 26.99 24.59 16 935 36721 29536855

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 32.15 19.13 11 2504 5699 64490518
Chronic sinusitis 23.68 19.13 9 2506 6283 64489934
Pyrexia 21.85 19.13 59 2456 558585 63937632
Jarisch-Herxheimer reaction 21.18 19.13 5 2510 682 64495535
Paraesthesia oral 20.25 19.13 10 2505 13121 64483096

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D001672 Biocompatible Materials
MeSH PA D004396 Coloring Agents
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:77182 food coloring

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
15FIX9V2JP UNII
4019139 VUID
N0000179267 NUI
D01931 KEGG_DRUG
4019139 VANDF
C0076733 UMLSCUI
CHEBI:32234 CHEBI
CHEMBL1201136 ChEMBL_ID
26042 PUBCHEM_CID
DB09536 DRUGBANK_ID
C009495 MESH_SUPPLEMENTAL_RECORD_UI
38323 RXNORM
NOCODE MMSL
001911 NDDF
432929006 SNOMEDCT_US
62036000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 35 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 50 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 50 mg TOPICAL OTC monograph not final 7 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.05 g TOPICAL OTC monograph final 8 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30 HUMAN OTC DRUG LABEL 2 0299-4111 LOTION 30 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4112 LOTION 49 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4122 LOTION 90 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Almay Line Smoothing Liquid Make-Up for Dry Skin HUMAN OTC DRUG LABEL 2 0311-0700 LIQUID 4.70 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Matching Makeup HUMAN OTC DRUG LABEL 2 0311-0701 LIQUID 4.80 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Anti- Aging Make-Up HUMAN OTC DRUG LABEL 2 0311-0702 LIQUID 3.90 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Smart Balance Make-Up HUMAN OTC DRUG LABEL 2 0311-0703 LIQUID 3.80 mg TOPICAL OTC monograph final 8 sections
Almay Wake-Up Liquid Make-Up HUMAN OTC DRUG LABEL 2 0311-0704 LIQUID 9 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 5.10 mg TOPICAL OTC monograph final 6 sections
Almay Age Smart Shade CC Luminous Primer SPF 15 HUMAN OTC DRUG LABEL 2 0311-0706 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
Almay Age Essentials Makeup SPF 15 HUMAN OTC DRUG LABEL 2 0311-0707 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
ALMAY SMART SHADE ANTI-AGING SKINTONE MATCHING MAKEUP SPF 20 HUMAN OTC DRUG LABEL 2 0311-0710 LIQUID 5.50 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 5.30 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5.80 mg TOPICAL OTC monograph final 7 sections
PanOxyl Oil Control Moisturizer HUMAN OTC DRUG LABEL 2 0316-0263 LOTION 10 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Baby HUMAN OTC DRUG LABEL 2 0316-2035 LOTION 54 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Baby SPF 50 Sunscreen HUMAN OTC DRUG LABEL 2 0316-2036 LOTION 89.60 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sensitive Sunscreen HUMAN OTC DRUG LABEL 2 0316-2045 LOTION 54 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Sensitive SPF 50 Sunscreen HUMAN OTC DRUG LABEL 2 0316-2046 LOTION 89.60 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sensitive Face Sunscreen HUMAN OTC DRUG LABEL 2 0316-2056 GEL 10 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Sheer Face SPF 50 Sunscreen HUMAN OTC DRUG LABEL 2 0316-2057 LOTION 99.90 mg TOPICAL OTC monograph not final 8 sections