titanium dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4237	13463-67-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: titanium dioxide titanium oxide	used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure Molecular weight: 79.87 Formula: O2Ti CLOGP: -1.32 LIPINSKI: None HAC: 2 HDO: 0 TPSA: 34.14 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

titanium dioxide
titanium oxide

used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure

Molecular weight: 79.87
Formula: O2Ti
CLOGP: -1.32
LIPINSKI: None
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 5, 2006	FDA	LOREAL USA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	901.62	22.43	224	3747	24152	63460899
Chronic sinusitis	280.47	22.43	78	3893	12765	63472286
Paraesthesia oral	245.09	22.43	77	3894	19179	63465872
Procedural pain	236.49	22.43	77	3894	21492	63463559
Drug ineffective	162.23	22.43	255	3716	1044510	62440541
Therapeutic product effect incomplete	136.08	22.43	89	3882	124967	63360084
Vaginal flatulence	134.87	22.43	33	3938	3260	63481791
Dyspepsia	126.70	22.43	79	3892	102117	63382934
Proctitis	118.43	22.43	33	3938	5408	63479643
Female genital tract fistula	116.28	22.43	35	3936	7524	63477527

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	94.12	26.72	20	1785	1280	34953846
SARS-CoV-2 test negative	81.34	26.72	17	1788	1003	34954123
Accident	67.18	26.72	20	1785	5027	34950099
Proctalgia	64.70	26.72	20	1785	5703	34949423
Haemorrhoids	49.77	26.72	21	1784	14554	34940572
Body temperature increased	46.23	26.72	21	1784	17347	34937779
Appendicolith	41.86	26.72	16	1789	8585	34946541
Ascites	33.75	26.72	24	1781	46547	34908579
Appendicitis	33.49	26.72	16	1789	14791	34940335
Ventricular fibrillation	29.53	26.72	17	1788	22937	34932189

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	266.93	21.61	74	5229	11222	79727863
Chronic sinusitis	260.97	21.61	75	5228	12951	79726134
Paraesthesia oral	223.54	21.61	74	5229	20397	79718688
Procedural pain	214.82	21.61	74	5229	23010	79716075
Vaginal flatulence	135.64	21.61	32	5271	2543	79736542
Therapeutic product effect incomplete	120.90	21.61	89	5214	141556	79597529
Female genital tract fistula	117.78	21.61	34	5269	5941	79733144
Dyspepsia	112.86	21.61	77	5226	108610	79630475
Proctitis	106.60	21.61	32	5271	6400	79732685
Vaginal discharge	101.91	21.61	32	5271	7431	79731654

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:77182	food coloring
MeSH PA	D001672	Biocompatible Materials
MeSH PA	D004396	Coloring Agents
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D017319	Photosensitizing Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D011838	Radiation-Sensitizing Agents
MeSH PA	D013473	Sunscreening Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001911	NDDF
15FIX9V2JP	UNII
26042	PUBCHEM_CID
38323	RXNORM
4019139	VUID
4019139	VANDF
432929006	SNOMEDCT_US
62036000	SNOMEDCT_US
C0076733	UMLSCUI
C009495	MESH_SUPPLEMENTAL_RECORD_UI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Age Essentials Makeup SPF 15	HUMAN OTC DRUG LABEL	2	0311-0707	LIQUID	4.30 mg	TOPICAL	OTC monograph final	8 sections
Almay Age Smart Shade CC Luminous Primer SPF 15	HUMAN OTC DRUG LABEL	2	0311-0706	LIQUID	4.30 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	5.30 mg	TOPICAL	OTC monograph final	5 sections
Almay Healthy Biome Makeup	HUMAN OTC DRUG LABEL	5	0311-0723	EMULSION	5.80 mg	TOPICAL	OTC monograph final	7 sections
Almay Line Smoothing Liquid Make-Up for Dry Skin	HUMAN OTC DRUG LABEL	2	0311-0700	LIQUID	4.70 mg	TOPICAL	OTC monograph final	8 sections
ALMAY SMART SHADE ANTI-AGING SKINTONE MATCHING MAKEUP SPF 20	HUMAN OTC DRUG LABEL	2	0311-0710	LIQUID	5.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade CC Cream	HUMAN OTC DRUG LABEL	3	0311-0705	LIQUID	5.10 mg	TOPICAL	OTC monograph final	6 sections
Almay Smart Shade Skintone Anti- Aging Make-Up	HUMAN OTC DRUG LABEL	2	0311-0702	LIQUID	3.90 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade Skintone Matching Makeup	HUMAN OTC DRUG LABEL	2	0311-0701	LIQUID	4.80 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade Smart Balance Make-Up	HUMAN OTC DRUG LABEL	2	0311-0703	LIQUID	3.80 mg	TOPICAL	OTC monograph final	8 sections

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