titanium dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4237 13463-67-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • titanium dioxide
  • titanium oxide
used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure
  • Molecular weight: 79.87
  • Formula: O2Ti
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 2006 FDA LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 703.86 20.48 165 2468 18743 56270691
Drug ineffective 142.71 20.48 192 2441 918797 55370637
Chronic sinusitis 127.37 20.48 36 2597 8342 56281092
Paraesthesia oral 100.11 20.48 34 2599 14415 56275019
Procedural pain 96.15 20.48 34 2599 16237 56273197
Therapeutic product effect incomplete 57.30 20.48 44 2589 105987 56183447
Dyspepsia 50.32 20.48 37 2596 83434 56206000
Pyrexia 39.23 20.48 70 2563 418703 55870731
Weight decreased 26.07 20.48 43 2590 240671 56048763
Jarisch-Herxheimer reaction 24.08 20.48 5 2628 315 56289119
Dermatophytosis 20.73 20.48 4 2629 173 56289261

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 47.55 27.59 15 1295 5716 31690318
Appendicitis 37.38 27.59 15 1295 11450 31684584
Ascites 36.25 27.59 22 1288 40991 31655043
Ventricular fibrillation 33.23 27.59 16 1294 18832 31677202
Cardiogenic shock 30.60 27.59 16 1294 22392 31673642
Constipation 30.18 27.59 31 1279 123960 31572074
Sepsis 30.01 27.59 34 1276 151895 31544139

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic sinusitis 115.20 20.10 34 3573 8417 70916420
Macular degeneration 114.60 20.10 33 3574 7495 70917342
Paraesthesia oral 87.61 20.10 32 3575 15385 70909452
Procedural pain 82.77 20.10 32 3575 17977 70906860
Therapeutic product effect incomplete 51.26 20.10 45 3562 119837 70805000
Appendicolith 44.57 20.10 15 3592 5665 70919172
Dyspepsia 43.29 20.10 36 3571 89041 70835796
Pyrexia 37.67 20.10 90 3517 606862 70317975
Appendicitis 28.92 20.10 15 3592 16718 70908119
Ascites 26.15 20.10 24 3583 67523 70857314
Nausea 24.90 20.10 97 3510 851991 70072846
Ventricular fibrillation 24.63 20.10 16 3591 27095 70897742
Sepsis 22.91 20.10 43 3564 244502 70680335
Cardiogenic shock 22.62 20.10 17 3590 36290 70888547
Weight decreased 22.44 20.10 49 3558 310439 70614398
Abdominal distension 20.62 20.10 26 3581 104643 70820194

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D001672 Biocompatible Materials
MeSH PA D004396 Coloring Agents
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:77182 food coloring

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
15FIX9V2JP UNII
4019139 VUID
N0000179267 NUI
D01931 KEGG_DRUG
4019139 VANDF
C0076733 UMLSCUI
CHEBI:32234 CHEBI
CHEMBL1201136 ChEMBL_ID
26042 PUBCHEM_CID
DB09536 DRUGBANK_ID
C009495 MESH_SUPPLEMENTAL_RECORD_UI
38323 RXNORM
NOCODE MMSL
001911 NDDF
432929006 SNOMEDCT_US
62036000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 35 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 50 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 50 mg TOPICAL OTC monograph not final 7 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.05 g TOPICAL OTC monograph final 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.05 g TOPICAL OTC monograph final 8 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30 HUMAN OTC DRUG LABEL 2 0299-4111 LOTION 30 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30 HUMAN OTC DRUG LABEL 2 0299-4111 LOTION 30 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4112 LOTION 49 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4122 LOTION 90 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4122 LOTION 90 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Almay Line Smoothing Liquid Make-Up for Dry Skin HUMAN OTC DRUG LABEL 2 0311-0700 LIQUID 4.70 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Matching Makeup HUMAN OTC DRUG LABEL 2 0311-0701 LIQUID 4.80 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Anti- Aging Make-Up HUMAN OTC DRUG LABEL 2 0311-0702 LIQUID 3.90 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Smart Balance Make-Up HUMAN OTC DRUG LABEL 2 0311-0703 LIQUID 3.80 mg TOPICAL OTC monograph final 8 sections
Almay Wake-Up Liquid Make-Up HUMAN OTC DRUG LABEL 2 0311-0704 LIQUID 9 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 5.10 mg TOPICAL OTC monograph final 6 sections
Almay Age Smart Shade CC Luminous Primer SPF 15 HUMAN OTC DRUG LABEL 2 0311-0706 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
Almay Age Essentials Makeup SPF 15 HUMAN OTC DRUG LABEL 2 0311-0707 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
ALMAY SMART SHADE ANTI-AGING SKINTONE MATCHING MAKEUP SPF 20 HUMAN OTC DRUG LABEL 2 0311-0710 LIQUID 5.50 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 5.30 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5.80 mg TOPICAL OTC monograph final 7 sections
PanOxyl Oil Control Moisturizer HUMAN OTC DRUG LABEL 2 0316-0263 LOTION 10 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Baby HUMAN OTC DRUG LABEL 2 0316-2035 LOTION 54 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Baby SPF 50 Sunscreen HUMAN OTC DRUG LABEL 2 0316-2036 LOTION 89.60 mg TOPICAL OTC monograph not final 9 sections