octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4236 5466-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octyl methoxycinnamate
  • octinoxate
  • ethylhexyl methoxycinnamate
  • ethylhexyl p-methoxycinnamate
  • Parsol MOX
  • Eusolex 2292
  • parsol
  • methoxycinnamate
a UV filter compound
  • Molecular weight: 290.40
  • Formula: C18H26O3
  • CLOGP: 5.96
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -5.81
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Squamous cell carcinoma of skin 185.60 27.69 35 610 5143 50599336
Skin atrophy 104.59 27.69 21 624 4224 50600255
Neoplasm skin 83.64 27.69 14 631 1026 50603453
Ochronosis 61.08 27.69 7 638 26 50604453
Product use in unapproved indication 39.24 27.69 22 623 115797 50488682

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Squamous cell carcinoma of skin 173.42 27.19 37 665 11839 64486191
Skin atrophy 104.78 27.19 21 681 4899 64493131
Neoplasm skin 83.87 27.19 14 688 1183 64496847
Ochronosis 59.85 27.19 7 695 39 64497991
Product use in unapproved indication 33.84 27.19 22 680 176596 64321434

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D02BA02 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for topical use
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Discoloration of skin indication 3253007
Chloasma indication 36209000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4Y5P7MUD51 UNII
4025697 VUID
N0000179014 NUI
D05225 KEGG_DRUG
4020294 VANDF
4020377 VANDF
4020661 VANDF
4025697 VANDF
C0046100 UMLSCUI
CHEBI:134750 CHEBI
CHEMBL3183184 ChEMBL_ID
CHEMBL1200608 ChEMBL_ID
5355130 PUBCHEM_CID
DB09496 DRUGBANK_ID
7945 INN_ID
C118580 MESH_SUPPLEMENTAL_RECORD_UI
C516303 MESH_SUPPLEMENTAL_RECORD_UI
13369 RXNORM
003659 NDDF
007440 NDDF
255902000 SNOMEDCT_US
411144000 SNOMEDCT_US
83834-59-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 75 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 75 mg TOPICAL OTC monograph not final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.08 g TOPICAL OTC monograph final 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 76 mg TOPICAL OTC monograph not final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 75 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 75 mg TOPICAL OTC monograph final 11 sections
Almay Wake-Up Liquid Make-Up HUMAN OTC DRUG LABEL 2 0311-0704 LIQUID 3.50 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 7.50 mg TOPICAL OTC monograph final 6 sections
Almay Age Essentials Makeup SPF 15 HUMAN OTC DRUG LABEL 2 0311-0707 LIQUID 3.50 mg TOPICAL OTC monograph final 8 sections
Almay Age Essentials Concealer SPF 20 HUMAN OTC DRUG LABEL 2 0311-0708 LIQUID 7.50 mg TOPICAL OTC monograph final 8 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 7.50 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 7.50 mg TOPICAL OTC monograph final 5 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 76.50 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 76.50 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Face HUMAN OTC DRUG LABEL 2 0316-2055 GEL 55 mg TOPICAL OTC monograph not final 8 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 10 g TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 75 mg TOPICAL OTC monograph not final 13 sections
Creal Zink Sunscreen SPF 50Well at Walgreens HUMAN OTC DRUG LABEL 3 0363-1117 STICK 7.50 g TOPICAL OTC monograph not final 7 sections
Walgreens SunscreenSPF 15 HUMAN OTC DRUG LABEL 2 0363-4001 LOTION 7.50 g TOPICAL OTC monograph not final 10 sections
Walgreens Dark Tanning Oil SunscreenSPF 4 HUMAN OTC DRUG LABEL 1 0363-4004 SPRAY 3 g TOPICAL OTC monograph not final 10 sections
Walgreens SunscreenSPF 45 SPF 45 SPF 45 HUMAN OTC DRUG LABEL 3 0363-4008 LOTION 7.50 g TOPICAL OTC monograph not final 10 sections
Walgreens Chap Aid Moisturizer HUMAN OTC DRUG LABEL 3 0363-8190 STICK 75 mg TOPICAL OTC monograph final 9 sections
Chapstick Moisturizer Original HUMAN OTC DRUG LABEL 3 0573-0725 STICK 75 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Chapstick Moisturizer Green Apple HUMAN OTC DRUG LABEL 3 0573-0728 STICK 75 mg TOPICAL OTC MONOGRAPH FINAL 14 sections