octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4236 5466-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octyl methoxycinnamate
  • octinoxate
  • ethylhexyl methoxycinnamate
  • ethylhexyl p-methoxycinnamate
  • Parsol MOX
  • Eusolex 2292
  • parsol
  • methoxycinnamate
a UV filter compound
  • Molecular weight: 290.40
  • Formula: C18H26O3
  • CLOGP: 5.96
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -5.81
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 837.90 21.55 216 4202 24160 63460444
Chronic sinusitis 254.32 21.55 74 4344 12769 63471835
Paraesthesia oral 224.79 21.55 74 4344 19182 63465422
Procedural pain 216.55 21.55 74 4344 21495 63463109
Drug ineffective 142.88 21.55 256 4162 1044509 62440095
Vaginal flatulence 131.36 21.55 33 4385 3260 63481344
Therapeutic product effect incomplete 127.37 21.55 89 4329 124967 63359637
Squamous cell carcinoma of skin 119.81 21.55 35 4383 6097 63478507
Proctitis 114.93 21.55 33 4385 5408 63479196
Dyspepsia 114.09 21.55 77 4341 102119 63382485
Female genital tract fistula 108.39 21.55 34 4384 7525 63477079
Radiculopathy 100.00 21.55 33 4385 8578 63476026
Vaginal discharge 97.87 21.55 33 4385 9165 63475439
Colitis ulcerative 70.50 21.55 35 4383 26056 63458548
Skin atrophy 70.04 21.55 22 4396 4884 63479720
Oral candidiasis 68.85 21.55 33 4385 22765 63461839
Frequent bowel movements 68.55 21.55 33 4385 22989 63461615
Weight decreased 63.96 21.55 87 4331 276711 63207893
Colitis 57.50 21.55 38 4380 48490 63436114
Pyrexia 56.73 21.55 110 4308 470368 63014236
Neoplasm skin 54.16 21.55 14 4404 1547 63483057
Rectal haemorrhage 52.36 21.55 36 4382 48994 63435610
Infusion related reaction 51.93 21.55 74 4344 245447 63239157
Haematochezia 49.50 21.55 36 4382 53508 63431096
Ochronosis 46.69 21.55 7 4411 40 63484564
Malaise 33.72 21.55 83 4335 415871 63068733
Nausea 27.08 21.55 124 4294 854347 62630257
Constipation 23.86 21.55 50 4368 224893 63259711

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 96.40 27.34 20 1591 1280 34954040
SARS-CoV-2 test negative 83.28 27.34 17 1594 1003 34954317
Accident 69.44 27.34 20 1591 5027 34950293
Proctalgia 66.96 27.34 20 1591 5703 34949617
Haemorrhoids 48.66 27.34 20 1591 14555 34940765
Body temperature increased 45.28 27.34 20 1591 17348 34937972
Appendicolith 43.64 27.34 16 1595 8585 34946735
Appendicitis 35.23 27.34 16 1595 14791 34940529
Ventricular fibrillation 31.35 27.34 17 1594 22937 34932383
Cardiogenic shock 29.00 27.34 17 1594 26601 34928719

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 255.42 18.92 72 5406 11224 79727686
Chronic sinusitis 245.28 18.92 72 5406 12954 79725956
Paraesthesia oral 213.24 18.92 72 5406 20399 79718511
Procedural pain 204.76 18.92 72 5406 23012 79715898
Vaginal flatulence 134.61 18.92 32 5446 2543 79736367
Therapeutic product effect incomplete 122.78 18.92 91 5387 141554 79597356
Female genital tract fistula 112.28 18.92 33 5445 5942 79732968
Dyspepsia 105.92 18.92 75 5403 108612 79630298
Proctitis 105.57 18.92 32 5446 6400 79732510
Vaginal discharge 100.89 18.92 32 5446 7431 79731479
Squamous cell carcinoma of skin 99.04 18.92 37 5441 13996 79724914
Radiculopathy 95.62 18.92 32 5446 8792 79730118
Anal inflammation 81.16 18.92 19 5459 1411 79737499
Skin atrophy 71.05 18.92 23 5455 5695 79733215
SARS-CoV-2 test negative 66.28 18.92 16 5462 1355 79737555
Pyrexia 65.89 18.92 144 5334 678565 79060345
Frequent bowel movements 61.15 18.92 33 5445 29506 79709404
Colitis ulcerative 58.80 18.92 34 5444 34708 79704202
Oral candidiasis 58.28 18.92 32 5446 29596 79709314
Infusion related reaction 57.87 18.92 75 5403 230162 79508748
Weight decreased 57.63 18.92 94 5384 355104 79383806
Neoplasm skin 53.89 18.92 14 5464 1597 79737313
Proctalgia 48.14 18.92 20 5458 9981 79728929
Accident 47.08 18.92 19 5459 8812 79730098
Malaise 46.32 18.92 103 5375 489766 79249144
Ochronosis 44.62 18.92 7 5471 57 79738853
Colitis 43.93 18.92 38 5440 73269 79665641
Rectal haemorrhage 42.62 18.92 38 5440 76262 79662648
Constipation 39.35 18.92 70 5408 282980 79455930
Appendicolith 37.48 18.92 16 5462 8535 79730375
Haematochezia 34.48 18.92 36 5442 87609 79651301
Pain 33.41 18.92 115 5363 703687 79035223
Nausea 31.30 18.92 139 5339 957057 78781853
Haemorrhoids 25.79 18.92 19 5459 29109 79709801
Appendicitis 24.10 18.92 16 5462 20778 79718132
Off label use 23.98 18.92 124 5354 907091 78831819
Body temperature increased 20.68 18.92 20 5458 44400 79694510
Ventricular fibrillation 20.03 18.92 17 5461 31909 79707001
Anal injury 19.41 18.92 4 5474 164 79738746

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D02BA02 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for topical use
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Discoloration of skin indication 3253007
Chloasma indication 36209000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4Y5P7MUD51 UNII
4025697 VUID
N0000179014 NUI
D05225 KEGG_DRUG
4020294 VANDF
4020377 VANDF
4020661 VANDF
4025697 VANDF
C0046100 UMLSCUI
CHEBI:134750 CHEBI
CHEMBL3183184 ChEMBL_ID
CHEMBL1200608 ChEMBL_ID
5355130 PUBCHEM_CID
DB09496 DRUGBANK_ID
7945 INN_ID
C118580 MESH_SUPPLEMENTAL_RECORD_UI
C516303 MESH_SUPPLEMENTAL_RECORD_UI
13369 RXNORM
003659 NDDF
007440 NDDF
255902000 SNOMEDCT_US
411144000 SNOMEDCT_US
83834-59-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 75 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 75 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 75 mg TOPICAL OTC monograph not final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.08 g TOPICAL OTC monograph final 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 76 mg TOPICAL OTC monograph not final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 75 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 75 mg TOPICAL OTC monograph final 11 sections
Almay Wake-Up Liquid Make-Up HUMAN OTC DRUG LABEL 2 0311-0704 LIQUID 3.50 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 7.50 mg TOPICAL OTC monograph final 6 sections
Almay Age Essentials Makeup SPF 15 HUMAN OTC DRUG LABEL 2 0311-0707 LIQUID 3.50 mg TOPICAL OTC monograph final 8 sections
Almay Age Essentials Concealer SPF 20 HUMAN OTC DRUG LABEL 2 0311-0708 LIQUID 7.50 mg TOPICAL OTC monograph final 8 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 7.50 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 7.50 mg TOPICAL OTC monograph final 5 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 76.50 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 76.50 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Face HUMAN OTC DRUG LABEL 2 0316-2055 GEL 55 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Face HUMAN OTC DRUG LABEL 2 0316-2055 GEL 55 mg TOPICAL OTC monograph not final 8 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 10 g TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 75 mg TOPICAL OTC monograph not final 13 sections