octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4236	5466-77-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: octyl methoxycinnamate octinoxate ethylhexyl methoxycinnamate ethylhexyl p-methoxycinnamate Parsol MOX Eusolex 2292 parsol methoxycinnamate	a UV filter compound Molecular weight: 290.40 Formula: C18H26O3 CLOGP: 5.96 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 35.53 ALOGS: -5.81 ROTB: 10 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

octyl methoxycinnamate
octinoxate
ethylhexyl methoxycinnamate
ethylhexyl p-methoxycinnamate
Parsol MOX
Eusolex 2292
parsol
methoxycinnamate

a UV filter compound

Molecular weight: 290.40
Formula: C18H26O3
CLOGP: 5.96
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 35.53
ALOGS: -5.81
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	837.90	21.55	216	4202	24160	63460444
Chronic sinusitis	254.32	21.55	74	4344	12769	63471835
Paraesthesia oral	224.79	21.55	74	4344	19182	63465422
Procedural pain	216.55	21.55	74	4344	21495	63463109
Drug ineffective	142.88	21.55	256	4162	1044509	62440095
Vaginal flatulence	131.36	21.55	33	4385	3260	63481344
Therapeutic product effect incomplete	127.37	21.55	89	4329	124967	63359637
Squamous cell carcinoma of skin	119.81	21.55	35	4383	6097	63478507
Proctitis	114.93	21.55	33	4385	5408	63479196
Dyspepsia	114.09	21.55	77	4341	102119	63382485

Showing 1 to 10 of 28 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	96.40	27.34	20	1591	1280	34954040
SARS-CoV-2 test negative	83.28	27.34	17	1594	1003	34954317
Accident	69.44	27.34	20	1591	5027	34950293
Proctalgia	66.96	27.34	20	1591	5703	34949617
Haemorrhoids	48.66	27.34	20	1591	14555	34940765
Body temperature increased	45.28	27.34	20	1591	17348	34937972
Appendicolith	43.64	27.34	16	1595	8585	34946735
Appendicitis	35.23	27.34	16	1595	14791	34940529
Ventricular fibrillation	31.35	27.34	17	1594	22937	34932383
Cardiogenic shock	29.00	27.34	17	1594	26601	34928719

Showing 1 to 10 of 10 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	255.42	18.92	72	5406	11224	79727686
Chronic sinusitis	245.28	18.92	72	5406	12954	79725956
Paraesthesia oral	213.24	18.92	72	5406	20399	79718511
Procedural pain	204.76	18.92	72	5406	23012	79715898
Vaginal flatulence	134.61	18.92	32	5446	2543	79736367
Therapeutic product effect incomplete	122.78	18.92	91	5387	141554	79597356
Female genital tract fistula	112.28	18.92	33	5445	5942	79732968
Dyspepsia	105.92	18.92	75	5403	108612	79630298
Proctitis	105.57	18.92	32	5446	6400	79732510
Vaginal discharge	100.89	18.92	32	5446	7431	79731479

Showing 1 to 10 of 39 entries

Previous1 2 3 4Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	D02BA02	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for topical use
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

Showing 1 to 6 of 6 entries

Previous1Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Discoloration of skin	indication	3253007
Chloasma	indication	36209000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

Show entries

Search:

ID	Source
003659	NDDF
007440	NDDF
13369	RXNORM
255902000	SNOMEDCT_US
4020294	VANDF
4020377	VANDF
4020661	VANDF
4025697	VUID
4025697	VANDF
411144000	SNOMEDCT_US

Showing 1 to 10 of 23 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Age Essentials Concealer SPF 20	HUMAN OTC DRUG LABEL	2	0311-0708	LIQUID	7.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Age Essentials Makeup SPF 15	HUMAN OTC DRUG LABEL	2	0311-0707	LIQUID	3.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	7.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	7.50 mg	TOPICAL	OTC monograph final	5 sections
Almay Smart Shade CC Cream	HUMAN OTC DRUG LABEL	3	0311-0705	LIQUID	7.50 mg	TOPICAL	OTC monograph final	6 sections
Almay Wake-Up Liquid Make-Up	HUMAN OTC DRUG LABEL	2	0311-0704	LIQUID	3.50 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Face	HUMAN OTC DRUG LABEL	2	0316-2055	GEL	55 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Face	HUMAN OTC DRUG LABEL	2	0316-2055	GEL	55 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Regular	HUMAN OTC DRUG LABEL	4	0316-2010	LOTION	76.50 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Sport Original Sunscreen	HUMAN OTC DRUG LABEL	4	0316-2019	LOTION	76.50 mg	TOPICAL	OTC monograph not final	8 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next